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https://www.readbyqxmd.com/read/29156366/triterpenoidal-saponins-from-the-fruits-of-gleditsia-caspica-with-proapoptotic-properties
#1
Usama Shaheen, Ehab A Ragab, Ashraf N Abdalla, Ammar Bader
Three previously undescribed oleanane-type triterpenoidal saponins named caspicaosides L-N were isolated from the fruits of Gleditsia caspica Desf. The aglycons of these saponins were echinocystic acid, erythrodiol and 12-oleanene-3,28,30-triol. Caspicaoside L is a bisdesmosidic saponin acylated with two monoterpenic acids. It has a disaccharide moiety made up of glucose and arabinose attached to C-3 and pentasaccharide moiety linked to C-28 made up of one glucose, 2 xyloses, one inner rhamnose and one terminal rhamnose which was acylated with two identical monoterpenic acids...
November 17, 2017: Phytochemistry
https://www.readbyqxmd.com/read/29155991/efficacy-and-safety-of-switching-to-pasireotide-in-acromegaly-patients-controlled-with-pegvisomant-and-first-generation-somatostatin-analogues-pape-study
#2
Ammar Muhammad, Aart J van der Lely, Patric J D Delhanty, Alof H G Dallenga, Iain K Haitsma, Joseph A M J L Janssen, Sebastian J C M M Neggers
Aim: To assess the efficacy and safety of pasireotide long-acting release (PAS-LAR) alone or in combination with pegvisomant by switching acromegaly patients who were well-controlled with somatostatin analogues (LA-SSAs) and pegvisomant to PAS-LAR with or without pegvisomant. Methods: 61 acromegaly patients were enrolled in a prospective open-label study. We included patients with an IGF-I ≤1.2 x Upper Limit of Normal (ULN) during treatment with LA-SSAs and pegvisomant...
November 15, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29152890/influenza-associated-severe-acute-respiratory-infections-in-two-sentinel-sites-in-lebanon-september-2015-to-august-2016
#3
Majd Saleh, Lara Bazzi, Ebstissam Ismail, Lina Mroueh, Nisrine Jammal, Amgad Elkholy, Pamela Mrad, Ahmad Al Samadi, Ahmad Hijazi, Firass Abiad, Ghazi Nsouli, Alissar Rady, Wasiq Khan, Mamunur Malik, Pierre Zalloua, Walid Ammar, Nada Ghosn
BACKGROUND: Given the sparse information on burden of influenza in Lebanon, the Ministry of Public Health established a sentinel surveillance for Severe Acute Respiratory Infections (SARI) to identify the attribution of influenza to reported cases. We aim to highlight the proportion of influenza-associated SARI from September 1(st) 2015 to August 31(st) 2016 in two Lebanese hospitals. METHODS: The study was conducted in two sentinel sites located in Beirut suburbs and Southern province of Lebanon...
November 20, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29138537/development-of-novel-ultrashort-antimicrobial-peptide-nanoparticles-with-potent-antimicrobial-and-antibiofilm-activities-against-multidrug-resistant-bacteria
#4
Ammar Almaaytah, Gubran Khalil Mohammed, Ahmad Abualhaijaa, Qosay Al-Balas
Conventional antibiotics are facing strong microbial resistance that has recently reached critical levels. This situation is leading to significantly reduced therapeutic potential of a huge proportion of antimicrobial agents currently used in clinical settings. Antimicrobial peptides (AMPs) could provide the medical community with an alternative strategy to traditional antibiotics for combating microbial resistance. However, the development of AMPs into clinically useful antibiotics is hampered by their relatively low stability, toxicity, and high manufacturing costs...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29135498/state-of-the-john-l-cameron-md-division-of-hepatobiliary-and-pancreatic-surgery-the-program-that-john-cameron-built
#5
Ammar A Javed, Christopher L Wolfgang
: The pancreatic surgery program at Johns Hopkins is recognized as being among the top programs in the field. It is part of the newly formed John L. Cameron Division of HPB surgery. This division of surgery is a highly productive group of academic surgeons in terms of clinical volume, research endeavors, and education. The division functions as part of a large multidisciplinary group at Johns Hopkins. The program has an interesting history and can trace its roots back to the actions of a single individual-John L...
November 13, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29128279/comparison-and-characterization-of-volatile-compounds-as-markers-of-oils-stability-during-frying-by-hs-spme-gc-ms-and-chemometric-analysis
#6
Ibtissem Ben Hammouda, Flavia Freitas, Sonda Ammar, M D R Gomes Da Silva, Mohamed Bouaziz
The formation and emission of volatile compounds, including the aldehydes and some toxic compounds of oil samples, ROPO pure (100%) and the blended ROPO/RCO (80-20%), were carried out during deep frying at 180°C. The volatile profile of both oil samples was evaluated by an optimized HS-SPME-GC/MS method, before and after 20, 40 and 60 successive sessions of deep-frying. Actually, from 100 detected compounds, aldehydes were found to be the main group formed. In addition, the oil degradation under thermal treatment regarding the volatile compounds were evaluated and compared...
November 2, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29119046/hemorrhagic-intracranial-follicular-dendritic-cell-sarcoma-a-case-report
#7
Neil Haranhalli, Adam E Ammar, Karen M Weidenheim, Marc K Rosenblum, David J Altschul
Background: Follicular dendritic cell (FDC) sarcoma is an extremely rare neoplasm, which has only been reported once in the literature with an intracranial occurrence. Neither hemorrhagic presentation of an intracranial instance of FDC sarcoma nor its rapid recurrence has yet been published in the literature. Case Description: We report the case of a 61-year-old female who presented with confusion and headaches secondary to a right frontal hemorrhagic lesion, and her subsequent presentations for recurrence of the lesion and finding of a new intracranial lesion...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29118864/rituximab-treatment-in-patients-with-systemic-sclerosis-and-interstitial-lung-disease
#8
Abdel Gaffar A Mohammed, Ammar Alshihre, Ibrahim Abdulrazag Al-Homood
There is increasing interest in rituximab (RTX) as an alternative to cyclophosphamide for the treatment of interstitial lung diseases (ILDs) associated with systemic sclerosis (SSc). However, no report has addressed its efficacy in Saudi patients with SSc-ILD. To assess the efficacy of RTX treatment in Saudi patients with SSc-ILD, hospital records were reviewed between 2013 and 2016. Four female patients received at least 4 cycles of RTX (I cycle, consisting of two infusions of 1000 mg 2 weeks apart). Pulmonary function tests (PFTs) and chest high-resolution computed tomography (HRCT) were performed before and after treatment to assess the response...
October 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29116382/selective-dorsal-rhizotomy-for-the-treatment-of-severe-spastic-cerebral-palsy-efficacy-and-therapeutic-durability-in-gmfcs-grade-iv-and-v-children
#9
Daniel D'Aquino, Ahmad A Moussa, Amr Ammar, Harshal Ingale, Michael Vloeberghs
BACKGROUND: Selective dorsal rhizotomy (SDR) has been established as an effective surgical treatment for spastic diplegia. The applicability of SDR to the full spectrum of spastic cerebral palsy and the durability of its therapeutic effects remain under investigation. There are currently limited data in the literature regarding efficacy and outcomes following SDR in Gross Motor Function Classification System (GMFCS) IV and V patients. Intrathecal baclofen has traditionally been the surgical treatment of choice for these patients...
November 7, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29114283/a-method-for-reconstruction-of-severely-damaged-spinal-cord-using-autologous-hematopoietic-stem-cells-and-platelet-rich-protein-as-a-biological-scaffold
#10
Ahmed Sabry Ammar, Yasser Osman, Ahmed Taher Hendam, Mohammed Ahmed Hasen, Fatma Abdullah Al Rubaish, Danya Yaagoub Al Nujaidi, Faisal Mishal Al Abbas
Introduction: There have been attempts to alter the prognosis of severe spinal cord injury in different centers, but none of which have reliably altered the outcome. Some trials use stem cells (SCs) that produced widely differing results. We hereby add our experience in our center of a surgical reconstruction of the damaged spinal cord using a mixture of SCs and Platelet-Rich Protein (PRP) with fibrin coated as a biological scaffold. Materials and Methods: Four cases of severely damaged spinal cord have been operated for neurolysis and reconstruction of the spinal cord using SCs and platelet-rich protein (PRP) with fibrin coated harvested from the peripheral circulation of the patient...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29113746/quinoline-derivatives-bearing-pyrazole-moiety-synthesis-and-biological-evaluation-as-possible-antibacterial-and-antifungal-agents
#11
Mohamed F El Shehry, Mostafa M Ghorab, Samir Y Abbas, Eman A Fayed, Said A Shedid, Yousry A Ammar
In an attempt for development of new antimicrobial agents, three series of quinoline derivatives bearing pyrazole moiety have been synthesized. The first series was synthesized through the synthesis of 4-(quinolin-2-yloxy)benzaldehyde and 4-(quinolin-2-yloxy)acetophenone and then treatment with ketone or aldehyde derivatives to afford the corresponding chalcones. Cyclization of the latter chalcones with hydrazine derivatives led to the formation of new pyrazoline derivatives. The second series was synthesized via the synthesis of 2-hydrazinylquinoline and then treatment with formylpyrazoles to afford the corresponding hydrazonyl pyrazole derivatives...
October 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29112005/john-l-cameron-md-overview-of-his-career
#12
Ammar A Javed, Matthew J Weiss, Christopher L Wolfgang
: Introduction to the John Cameron Festschrift.
November 3, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29111543/syncope-in-young-women-broadening-the-differential-diagnosis
#13
Nachiket Patel, Naila Choudhary, Christine Tompkins, Khawaja Afzal Ammar, A Jamil Tajik, Krishnaswamy Chandrasekaran, Timothy E Paterick
Syncope is defined as a sudden transient loss of consciousness (TLOC) with concomitant loss of postural tone followed by spontaneous recovery. It is a subset of a broader class of medical conditions, including postural orthostatic tachycardia syndrome (POTS), orthostatic hypotension, and neurally mediated syncope (NMS), that may result in TLOC. The overlap of these clinical conditions leads to confusion regarding syncope classification that can hinder evaluation strategies, and pose challenges for diagnosis and treatment, particularly in young women...
2017: Reviews in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29110291/non-ionic-surfactant-based-in-situ-forming-vesicles-as-controlled-parenteral-delivery-systems
#14
Hussein O Ammar, Magdy Ibrahim, Azza A Mahmoud, Rehab N Shamma, Nada M El Hoffy
Non-ionic surfactant (NIS) based in situ forming vesicles (ISVs) present an affordable alternative to the traditional systems for the parenteral control of drug release. In this work, NIS based ISVs encapsulating tenoxicam were prepared using the emulsion method. Tenoxicam-loaded ISVs were prepared using a 2(2).3(1) full factorial experimental design, where three factors were evaluated as independent variables; type of NIS (A), molar ratio of NIS to Tween®80 (B), and phase ratio of the internal ethyl acetate to the external Captex® oil phase (C)...
November 6, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29103622/a-new-multi-stage-combined-kernel-filtering-approach-for-ecg-noise-removal
#15
Mazhar B Tayel, Ahmed S Eltrass, Abeer I Ammar
Electrocardiogram (ECG) signals are contaminated with different artifacts and noise sources which increase the difficulty in analyzing the ECG signals and obtaining accurate diagnosis of heart diseases. In this paper, a new multi-stage combined adaptive filtering design based on Kernel Recursive Least Squares Tracker (KRLST) and Kernel Recursive Least Squares with Approximate Linear Dependency (ALDKRLS) algorithms is proposed for removing artifacts and noise sources, while preserving the low frequency components and the tiny features of the ECG signal...
October 18, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29103172/does-constant-photoperiod-inhibit-the-onset-of-the-reproductive-cycle-in-northern-pike-esox-lucius-males
#16
I Ben Ammar, S Milla, H Missaoui, Y Ledoré, F Teletchea, P Fontaine
For most temperate and arctic fish species, photoperiod is the key abiotic factor determining the onset of the reproductive cycle, and, for many species, constant long photoperiod seems to have an inhibitory effect. Yet, there is no knowledge about the effect of photoperiod on the onset of the reproductive cycle in northern pike males. The aim of this work was to investigate the potential inhibitory effect of constant long photoperiod on pike males. Batches of fish were reared in triplicate under natural simulated photoperiod (NSP) or constant long photoperiod (CP; 16L:8D) from 14 October 2013 to 14 March 2014...
November 4, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29096112/modulation-of-wettability-gradient-and-adhesion-on-self-assembled-monolayer-by-counterion-exchange-and-ph
#17
Jaroslav Mosnáček, Anton Popelka, Josef Osicka, Jaroslav Filip, Marketa Ilcikova, Jozef Kollar, Ammar B Yousaf, Tomas Bertok, Jan Tkac, Peter Kasak
In this study, two quaternary ammonium salts derived from l-lipoic acid were applied for self-assembled monolayers formation on rough structured gold surface. The derivatives differ in functionality since one possesses simple quaternary ammonium group whereas the other one is carboxybetaine ester containing quaternary ammonium group with pH hydrolysable ester group as a pendant. The response of surface wettability to ion exchange between Cl(-) and perfluorooctanoate, kinetics and gradient wettability were examined by water contact angle measurement and confirmed by X-ray photoelectron spectroscopy...
October 25, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29090103/unilateral-atraumatic-expulsion-of-an-ectopic-pregnancy-in-a-case-of-bilateral-ectopic-pregnancy
#18
Victoria Sampson, Oluremi Mogekwu, Ammar Ahmed, Farida Bano
Ectopic pregnancy occurs in 1-2% of pregnancies. The fallopian tube is the most common site; however, bilateral tubal ectopic pregnancy is an extremely rare phenomenon, seen in approximately 1/200,000 pregnancies. It is usually the result of assisted reproductive techniques (ART). Ultrasound (USS) and serial beta-hCG levels have shown poor efficacy for accurate diagnosis. Laparoscopy is the diagnostic gold standard. The majority of cases are managed surgically with bilateral salpingectomy. A 26-year-old female presented to our early pregnancy unit with pain and vaginal bleeding at 5-week gestation after IVF...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29090044/temporal-and-spatial-flap-variability-in-laser-in-situ-keratomileusis-by-optical-coherence-tomography
#19
Yousif Farhan Dawood, Usama Al Hassany, Ammar F Issa
PURPOSE: To study changes in flap thickness made with two different microkeratome heads across different corneal locations using anterior segment optical coherence tomography (OCT). METHODS: In this prospective, non-randomized, consecutive case series, subjects who had their laser in-situ keratomileusis (LASIK) flaps made using 90 μm (MSU90) or 130 μm (MSU130) disposable M2 microkeratome heads were examined using OCT. The measurements were performed at three locations (central and 2...
October 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29082657/segmental-branching-pattern-of-the-left-portal-vein-anatomical-characteristics-and-clinical-implications
#20
Haythem Najah, Houssem Ammar, Rahul Gupt, Moncef Hamdoun, Abdelwaheb Morjane, Mongi Mighri, Sadok Sassi
INTRODUCTION: The existing knowledge on anatomy of segmental branches of left portal vein (LPV) is limited. This study aims to describe the surgical anatomy and variations of LPV and its segmental branching pattern. MATERIALS AND METHODS: Forty fresh cadaveric liver dissections were performed. The dissection of LPV was carried out from its emergence at the level of the portal vein bifurcation to its segmental branches penetrating the left hemiliver. LPV characteristics, the number and situation of its segmental branches were recorded...
October 30, 2017: Clinical Anatomy
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