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https://www.readbyqxmd.com/read/29350169/containment-of-highly-pathogenic-avian-influenza-a-h5n1-virus-lebanon-20161
#1
Zeina E Farah, Omaya Khatib, Sahar Hamadeh, Khadija Ahmad, Bassel El Bazzal, Pierre Zalloua, Walid Ammar, Nada Ghosn
A preparedness plan for avian influenza A(H5N1) virus infection was activated in Lebanon in 2016 after reported cases in poultry. Exposed persons were given prophylaxis and monitored daily. A total of 185 exposed persons were identified: 180 received prophylaxis, 181 were monitored, and 41 suspected cases were reported. All collected specimens were negative for virus by PCR.
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29349737/teratogenic-effects-induced-by-chitosan-oligosaccharide-in-wistar-female-rat-rattus-norvegicus
#2
Amal Abdel Aziz Eisa, Gamal El-Sayed Aboelghar, Ibrahim Mahmoud Ammar, Hala Gabr Metwally, Samah Saied Arafa
The aim of this research is to investigate the teratogenic effects of chitosan oligosaccharide in Wistar female rats (Rattus norvegicus). Chitosan LD50 value was calculated by probit analysis. High dose, 1/10 LD50 which equal to 150 mg/kg body weight, and low dose, 1/30 LD50 which equal to 50 mg/kg body weight, were administrated orally to Wistar female rats to examine the teratogenic effect during organogenesis period from 6th day to 15th day of gestation. Treated and control rats were sacrificed and their foetuses were examined for external, skeletal and visceral anomalies, number and length of foetuses and their weights...
January 18, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29348438/procalcitonin-guiding-antimicrobial-therapy-duration-in-febrile-cancer-patients-with-documented-infection-or-neutropenia
#3
Hanine El Haddad, Anne-Marie Chaftari, Ray Hachem, Majd Micheal, Ying Jiang, Ammar Yousif, Sammy Raad, Mary Jordan, Patrick Chaftari, Issam Raad
In this analysis, we identified febrile cancer patients with documented infections or neutropenia, whose procalcitonin levels are low at baseline or decrease on antibiotics. These patients had similar outcomes in terms of mortality and relapse of infection regardless of the duration of antimicrobial therapy (less or more than 7 days).
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348365/detection-and-localization-of-surgically-resectable-cancers-with-a-multi-analyte-blood-test
#4
Joshua D Cohen, Lu Li, Yuxuan Wang, Christopher Thoburn, Bahman Afsari, Ludmila Danilova, Christopher Douville, Ammar A Javed, Fay Wong, Austin Mattox, Ralph H Hruban, Christopher L Wolfgang, Michael G Goggins, Marco Dal Molin, Tian-Li Wang, Richard Roden, Alison P Klein, Janine Ptak, Lisa Dobbyn, Joy Schaefer, Natalie Silliman, Maria Popoli, Joshua T Vogelstein, James D Browne, Robert E Schoen, Randall E Brand, Jeanne Tie, Peter Gibbs, Hui-Li Wong, Aaron S Mansfield, Jin Jen, Samir M Hanash, Massimo Falconi, Peter J Allen, Shibin Zhou, Chetan Bettegowda, Luis Diaz, Cristian Tomasetti, Kenneth W Kinzler, Bert Vogelstein, Anne Marie Lennon, Nickolas Papadopoulos
Earlier detection is key to reducing cancer deaths. Here we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1,005 patients with non-metastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69% to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals...
January 18, 2018: Science
https://www.readbyqxmd.com/read/29341900/lamotrigine-loaded-poly-%C3%A9-d-l-lactide-co-caprolactone-nanoparticles-as-brain-delivery-system
#5
Hussein O Ammar, Mahmoud M Ghorab, Azza A Mahmoud, Iman M Higazy
Management of epilepsy requires brain delivery therapy, therefore, this study was aimed to prepare lamotrigine loaded poly-ɛ-(d,l-lactide-co-caprolactone) (PLCL) nanoparticles using spontaneous emulsification solvent diffusion method. Nanoparticles for brain delivery required to have a particle size <200 nm, polydispesity index <0.2 and a sustained drug release properties. For such aim different factors were considered in preparing the nanoparticles as PLCL monomers' ratio, type of organic solvent used to prepare the nanoparticles, amount of PLCL and Pluronic®F127 in the nanoparticles...
January 13, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29340014/cymbopogon-citratus-and-camellia-sinensis-extracts-selectively-induce-apoptosis-in-cancer-cells-and-reduce-growth-of-lymphoma-xenografts-in-vivo
#6
Cory Philion, Dennis Ma, Ivan Ruvinov, Fadi Mansour, Christopher Pignanelli, Megan Noel, Ammar Saleem, John Arnason, Mark Rodrigues, Inderpal Singh, Jesse Ropat, Siyaram Pandey
Cancer cells are reported to have elevated levels of reactive oxygen species (ROS) and are highly dependent on cellular defense mechanisms against oxidative stress. Numerous nutraceuticals and natural polyphenolic compounds have a wide range of abilities to alter cellular redox states with potential implications in various diseases. Furthermore, therapeutic options for cancers are mostly nonselective treatments including genotoxic or tubulin-targeting compounds. Some of the natural extracts, containing multiple bioactive compounds, could target multiple pathways in cancer cells to selectively induce cell death...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339639/mri-guided-interstitial-laser-ablation-for-intracranial-lesions-a-large-single-institution-experience-of-133-cases
#7
Ashwin A Kamath, Daniel D Friedman, Carl D Hacker, Matthew D Smyth, David D Limbrick, Albert H Kim, Ammar H Hawasli, Eric C Leuthardt
BACKGROUND: Managing difficult-to-access lesions or surgically accessible lesions in fragile patients is a central problem in neurosurgery. MRI-guided interstitial laser ablation (ILA) is a minimally invasive option that may provide a safe means of treating these challenging patients. OBJECTIVE: We aim to (1) evaluate safety, efficacy, and preliminary outcomes within a diverse and large series of ILA treatments; and (2) report technical details and operative trends that proved useful over time in the authors' experience and that may be of use to neurosurgeons who perform ILA...
January 17, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29338147/effect-of-therapeutic-hypothermia-on-survival-and-neurological-outcome-in-adults-suffering-cardiac-arrest-a-systematic-review-and-meta-analysis
#8
Sameh M Hakim, Mona A Ammar, Mohammad S Reyad
INTRODUCTION: The aim of this review is to determine current evidence for the effect of therapeutic hypothermia (TH) on survival and neurological outcome in adults suffering cardiac arrest (CA). EVIDENCE AQUISITION: We searched the Cochrane Controlled Trials Register, MEDLINE, EMBASE and NLM databases from 2000 to 2017 using the following terms: hypothermia, cooling, therapeutic, cardiac arrest, resuscitation, cardiopulmonary, CPR. Studies were eligible if they compared TH versus normothermic management in adult humans sustaining CA...
January 16, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29334562/is-a-pathological-complete-response-following-neoadjuvant-chemoradiation-associated-with-prolonged-survival-in-patients-with-pancreatic-cancer
#9
Jin He, Alex B Blair, Vincent P Groot, Ammar A Javed, Richard A Burkhart, Georgios Gemenetzis, Ralph H Hruban, Kevin M Waters, Justin Poling, Lei Zheng, Daniel Laheru, Joseph M Herman, Martin A Makary, Matthew J Weiss, John L Cameron, Christopher L Wolfgang
OBJECTIVES: To describe the survival outcome of patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma (BR/LA-PDAC) who have a pathologic complete response (pCR) following neoadjuvant chemoradiation. BACKGROUND: Patients with BR/LA-PDAC are often treated with neoadjuvant chemoradiation in an attempt to downstage the tumor. Uncommonly, a pCR may result. METHODS: A retrospective review of a prospectively maintained database was performed at a single institution...
January 12, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29334315/interplay-between-p53-and-ink4c-in-spermatogenesis-and-fertility
#10
Hassan Zalzali, Wisam Rabeh, Omar Najjar, Rami Abi Ammar, Mohamad Harajly, Raya Saab
The tumor suppressor p53, and the cyclin-dependent kinase inhibitor Ink4c, have been both implicated in spermatogenesis control. Both p53-/- and Ink4c-/- single knockout male mice are fertile, despite testicular hypertrophy, Leydig cell differentiation defect, and increased sperm count in Ink4c-/- males. To investigate their collaborative roles, we studied p53-/- Ink4c-/- dual knockout animals, and found that male p53-/- Ink4c-/- mice have profoundly reduced fertility. Dual knockout male mice show a marked decrease in sperm count, abnormal sperm morphology and motility, prolongation of spermatozoa proliferation and delay of meiosis entry, and accumulation of DNA damage...
January 15, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29334134/a-comprehensive-next-generation-sequencing-assay-for-the-diagnosis-of-epidermolysis-bullosa
#11
Anne W Lucky, Neha Dagaonkar, Karen Lammers, Ammar Husami, Diane Kissell, Kejian Zhang
BACKGROUND: Historically, diagnosis of epidermolysis bullosa has required skin biopsies for electron microscopy, direct immunofluorescence to determine which gene(s) to choose for genetic testing, or both. METHODS: To avoid these invasive tests, we developed a high-throughput next-generation sequencing (NGS)-based diagnostic assay called EBSEQ that allows simultaneous detection of mutations in 21 genes with known roles in epidermolysis bullosa pathogenicity. Mutations are confirmed with traditional Sanger sequencing...
January 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29331580/local-delivery-of-mometasone-furoate-from-an-eluting-endotracheal-tube
#12
Abu Ammar Aiman, Maayan Gruber, Patrick Martin, Ohad Stern, Forsan Jahshan, Offir Ertracht, Eyal Sela, Samer Srouji, Eyal Zussman
Laryngeal and tracheal morbidity is a common complication of endotracheal tube (ETT)-based airway management, and manifests as local irritation, inflammation, and edema. Systemic corticosteroids are commonly administered to manage these conditions; however, their efficacy is inadequate and limited by potential severe side effects. In the present study, a steroid delivery system for local therapy was developed to generate relatively high local drug concentrations and to improve drug efficacy. ETTs were coated with electrospun poly (lactic-co-glycolic acid) (PLGA) nanofibers loaded with mometasone furoate (MF), creating a microscale thick layer...
January 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29330542/regulation-of-metabolism-in-escherichia-coli-during-growth-on-mixtures-of-the-non-glucose-sugars-arabinose-lactose-and-xylose
#13
Ehab M Ammar, Xiaoyi Wang, Christopher V Rao
Catabolite repression refers to the process where the metabolism of one sugar represses the genes involved in metabolizing another sugar. While glucose provides the canonical example, many other sugars are also known to induce catabolite repression. However, less is known about the mechanism for catabolite repression by these non-glucose sugars. In this work, we investigated the mechanism of catabolite repression in the bacterium Escherichia coli during growth on lactose, L-arabinose, and D-xylose. The metabolism of these sugars is regulated in a hierarchical manner, where lactose is the preferred sugar, followed by L-arabinose, and then D-xylose...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29325390/translation-adaptation-and-cross-language-validation-of-tinnitus-handicap-inventory-in-urdu
#14
Muhammad Aqeel, Ammar Ahmed
BACKGROUND AND OBJECTIVES: Tinnitus is characterized as a perception of numerous auditory sounds in absence of external stimulus. Tinnitus can have a considerable consequence on a person's quality of life, and is considered to be very complicated to quantify. The aim of this study was to investigate the reliability and validity of Urdu translation of the Tinnitus Handicap Inventory (THI) in Pakistan. It was designed to assess the presence of various auditory sounds without the external stimulus...
December 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29315604/trends-of-genetic-screening-in-patients-with-pheochromocytoma-and-paraganglioma-15-year-experience-in-a-high-volume-tertiary-referral-center
#15
Ammar Asban, Wouter P Kluijfhout, Frederick T Drake, Toni Beninato, Elizabeth Wang, Kate Chomsky-Higgins, Wen T Shen, Jessica E Gosnell, Insoo Suh, Quan-Yang Duh
BACKGROUND AND OBJECTIVES: Genetic testing for pheochromocytoma and paraganglioma allows for early detection of hereditary syndromes and enables close follow-up of high-risk patient. We investigated the trends in genetic testing among patients at a high-volume referral center and evaluated the prevalence of pheochromocytomas and paragangliomas. METHODS: We reviewed the charts of 129 patients who underwent adrenalectomy for pheochromocytoma and paraganglioma between January 2000 and July 2015...
January 8, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29315424/cardiac-resynchronization-therapy-in-patients-with-end-stage-hypertrophic-cardiomyopathy
#16
Ammar M Killu, Jae-Yoon Park, Jaskanwal D Sara, David O Hodge, Bernard J Gersh, Rick A Nishimura, Samuel J Asirvatham, Christopher J McLeod
Aims: A dilated/end-stage phase of hypertrophic cardiomyopathy (HCM) is rare but well-recognized. The role for cardiac resynchronization therapy (CRT) in this subset of patients remains unexplored. We aimed to clarify the impact of bi-ventricular pacing CRT in dilated/end-stage HCM. Methods and results: The Mayo Clinic HCM database was interrogated to identify patients with ejection fraction (EF) <50% and CRT. Control subjects were identified in 1:1 manner...
January 1, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29315140/high-intrapatient-variability-of-tacrolimus-exposure-in-the-early-period-after-liver-transplantation-is-associated-with-poorer-outcomes
#17
Michel Rayar, Camille Tron, Caroline Jézéquel, Jean Marie Beaurepaire, Antoine Petitcollin, Pauline Houssel-Debry, Christophe Camus, Marie Clémence Verdier, Ammar Dehlawi, Mohamed Lakéhal, Véronique Desfourneaux, Bernard Meunier, Laurent Sulpice, Eric Bellissant, Karim Boudjema, Florian Lemaitre
BACKGROUND: Tacrolimus (TAC) is the cornerstone of immunosuppressive regimen in liver transplantation (LT). Its pharmacokinetics is characterized by a high inter- and intrapatient variability leading to an unpredictable dose-response relationship. The aim of our study was to evaluate the impact of TAC intrapatient variability (IPV) on graft and patient outcomes after liver transplantation. METHODS: We retrospectively analyzed 812 LT recipients treated with TAC. The IPV of TAC concentrations was estimated by calculating the coefficient of variation (CV) of whole blood trough concentrations...
January 8, 2018: Transplantation
https://www.readbyqxmd.com/read/29311247/diaphorina-citri-nymphs-are-resistant-to-morphological-changes-induced-by-candidatus-liberibacter-asiaticus-in-midgut-epithelial-cells
#18
Marina Mann, Somayeh Fattah-Hosseini, El-Desouky Ammar, Richard Stange, EricaRose Warrick, Kasie Sturgeon, Robert Shatters, Michelle Heck
"Candidatus Liberibacter asiaticus" is the causative bacterium associated with citrus greening disease. "Ca. L. asiaticus" is transmitted by Diaphorina citri more efficiently when it is acquired by nymphs rather than adults. Why this occurs is not known. We compared midguts of D. citri reared on healthy or "Ca. L. asiaticus"-infected citrus trees using quantitative PCR, confocal microscopy, and mitochondrial superoxide staining for evidence of oxidative stress. Consistent with its classification as propagative, "Ca...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29311231/capsule-prolongs-survival-of-streptococcus-pneumoniae-during-starvation
#19
Shigeto Hamaguchi, M Ammar Zafar, Michael Cammer, Jeffrey N Weiser
Person-to-person transmission of Streptococcus pneumoniae (the pneumococcus) may occur via environmental sources in close contact with carriers. Pneumococcal polysaccharide capsules, the determinant of serotype (or type), are heterogeneous in structure and amount and these differences affect rates of transmission. In this study, we examined the contribution of capsule and its variations to the maintenance of pneumococcal viability under starvation conditions. S. pneumoniae retained its ability to colonize infant mice even after incubation for 24hrs in PBS at 25°C...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29306850/allergy-in-patients-with-anti-n-methyl-d-aspartate-receptor-encephalitis
#20
Xin-Yue Jiang, Le Zhang, Xian Jiang, Ammar Taha Abdullah Abdulaziz, Yun-Hui Wang, Jin-Mei Li, Dong Zhou
BACKGROUND AND OBJECTIVE: Allergy is a potential outcome of dysregulated immune system. Previous studies have shown the association of allergy and autoimmune diseases, however, there is few study to investigate the relationship between allergy and anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. Thus, we investigate the rate of allergy in patients with anti-NMDAR encephalitis and analyze the risk factors. METHOD: The rate of allergy was investigated in patients with anti-NMDAR encephalitis and was compared with patients with virus encephalitis...
January 4, 2018: Epilepsy & Behavior: E&B
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