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https://www.readbyqxmd.com/read/28230638/mtor-inhibition-cardiovascular-diseases-dyslipidemia-and-atherosclerosis
#1
Ammar Kurdi, Wim Martinet, Guido R Y De Meyer
Inhibitors of the mechanistic target of rapamycin (mTOR) have unique anti-atherosclerotic effects such as depletion of plaque macrophages, induction of autophagy and activation of cholesterol efflux. However, a common side effect of their use is dyslipidemia, a well-known risk factor for atherosclerosis. Indeed, mTOR inhibitors prevent lipid storage, increase LDL cholesterol levels and activate lipolysis. Although the net effect of mTOR inhibition seems favorable, the use of cholesterol lowering drugs to manage dyslipidemia remains the most recommended strategy...
February 23, 2017: Transplantation
https://www.readbyqxmd.com/read/28228231/evaluating-community-pharmacists-perspectives-and-practices-concerning-generic-medicines-substitution-in-saudi-arabia-a-cross-sectional-study
#2
Fahad S Alkhuzaee, Hamdan M Almalki, Ammar Y Attar, Shoeab I Althubiani, Wassam Ali Almuallim, Ejaz Cheema, Muhammad Abdul Hadi
OBJECTIVES: To assess the community pharmacists' knowledge, attitude, perception and current practices towards generic medicines substitution in Saudi Arabia. METHODS: A cross-sectional study was conducted between February and March 2016 in the Makkah region, Saudi Arabia. A 25-item, structured, validated, pilot-tested and self-completed questionnaire was used to achieve study objectives. A 4-step systematic sampling technique was used to recruit community pharmacists...
December 2016: Health Policy
https://www.readbyqxmd.com/read/28226292/hplc-dad-qtof-ms-profiling-of-phenolics-from-leaf-extracts-of-two-tunisian-fig-cultivars-potential-as-a-functional-food
#3
Olfa Belguith-Hadriche, Sonda Ammar, María Del Mar Contreras, Hamadi Fetoui, Antonio Segura-Carretero, Abdelfattah El Feki, Mohamed Bouaziz
The phenolic constituents of the aqueous-ethanolic extract of two Tunisian Ficus carica leaves cultivars and their hypoglycaemic, hypolipidaemic and antioxidative activities in alloxan-induced diabetic rats were investigated. Our results demonstrated that the treatment with the leaves extracts of F. carica improved lipid profile and reduced blood glucose level as well as thiobarbituric acid-reactive substances content. The antioxidant enzymes activity in the liver and heart tissues of diabetic rats was increased after the treatment...
February 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28224638/assessment-of-human-sperm-dna-integrity-using-two-cytochemical-tests-acridine-orange-test-and-toluidine-blue-assay
#4
T Ajina, O Ammar, Z Haouas, A Sallem, L Ezzi, I Grissa, W Sakly, A Jlali, M Mehdi
Primary infertility affects approximately 15% of couples, with male factor infertility accounting for 50% of cases. Semen samples from 41 patients with asthenoteratospermia and 28 men with proven fertility were analysed according to World Health Organization guidelines. Abnormal sperm chromatin structure was assessed by toluidine blue assay (TBA), and DNA denaturation (DD) was detected by the acridine orange test (AOT). The mean (±SEM) rates of DD and abnormal chromatin structure were significantly higher in infertile subjects compared to fertile group respectively p = ...
February 22, 2017: Andrologia
https://www.readbyqxmd.com/read/28222580/acute-and-delayed-responses-of-steroidal-hormones-blood-lactate-and-biomarkers-of-muscle-damage-after-a-resistance-training-session-time-of-day-effects
#5
Achraf Ammar, Hamdi Chtourou, Mouna Turki, Omar Hammouda, Ahmed Chaari, Mariem Boudaya, Tarak Driss, Fatma Ayedi, Nizar Souissi
BACKGROUND: The present study aimed to investigate the effect of time-of-days (TOD) on some biochemical and hormonal responses after resistance training sessions. METHODS: Ten trained subjects (22±2 years) performed, in randomized order, three resistance-training-sessions at 07h:00, 13h:00 and 17h:00. Each training-session included six upper and lower body resistance exercises with 3×10 repetitions. Blood lactate (Lac), creatine kinase (CK), lactate dehydrogenase (LDH), cortisol (C) and testosterone (T) were collected at rest, 3min and 48h after each-session...
February 21, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28217375/lymphocyte-to-monocyte-ratio-can-predict-mortality-in-pancreatic-adenocarcinoma
#6
Gurshawn Singh, Ammar Nassri, David Kim, Hong Zhu, Zeeshan Ramzan
AIM: To determine if the lymphocyte-to-monocyte ratio (LMR) could be helpful in predicting survival in patients with pancreatic adenocarcinoma. METHODS: We retrospectively reviewed the medical records of all patients diagnosed with pancreatic adenocarcinoma in the VA North Texas Healthcare System from January 2005 to December 2010. The LMR was calculated from peripheral blood cell counts obtained at the time of diagnosis of pancreatic cancer by dividing the absolute lymphocyte count by the absolute monocyte count...
February 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28214762/paracaecal-hernia-a-case-report-on-the-evolving-role-of-laparoscopy
#7
Ammar Tayaran, Haider Abdulrasool, Hai T Bui
A paracaecal hernia, a type of pericaecal hernias, is a rare cause of small intestinal obstruction. Failure of early recognition and reduction of this type of internal hernia may lead to strangulation of the herniated intestine. There has been a number of case reports in the literature about the different types of pericaecal hernias, however the anatomy of these hernias is still poorly understood and the management is still evolving. We are presenting a 75year old woman, who presented clinically and radiologically with distal small intestinal obstruction...
January 17, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28208246/combined-proteome-and-eicosanoid-profiling-approach-for-revealing-implications-of-human-fibroblasts-in-chronic-inflammation
#8
Ammar Tahir, Andrea Bileck, Besnik Muqaku, Laura Niederstaetter, Dominique Kreutz, Rupert L Mayer, Denise Wolrab, Samuel M Meier, Astrid Slany, Christopher Gerner
During inflammation, proteins and lipids act in a concerted fashion, calling for combined analyses. Fibroblasts are powerful mediators of chronic inflammation. However, little is known about eicosanoid formation by human fibroblasts. The aim of this study was to analyze the formation of the most relevant inflammation mediators including proteins and lipids in human fibroblasts upon inflammatory stimulation and subsequent treatment with dexamethasone, a powerful antiphlogistic drug. Label-free quantification was applied for proteome profiling, while an in-house established data-dependent analysis method based on high-resolution mass spectrometry was applied for eicosadomics...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28197590/rats-urinary-metabolomes-reveal-the-potential-roles-of-functional-foods-and-exercise-in-obesity-management
#9
Mohamed A Farag, N M Ammar, T E Kholeif, N S Metwally, N M El-Sheikh, Ludger A Wessjohann, A Z Abdel-Hamid
The complexity of the metabolic changes in obese individuals still presents a challenge for the understanding of obesity-related metabolic disruptions and for obesity management. In this study, a gas chromatography mass spectrometry (GC-MS) based metabolomics approach targeting urine metabolism has been applied to assess the potential roles of functional foods and exercise for obesity management in rats. Male albino rats diagnosed as obese via histopathology and biochemical assays were administered functional foods in common use for obesity management including pomegranate, grapefruit, and red cabbage juice extracts in parallel with swimming exercise...
February 15, 2017: Food & Function
https://www.readbyqxmd.com/read/28193645/not-your-usual-constipation-stercoral-perforation
#10
Matthew Marget, Hussam Ammar
Stercoral perforation is a rare cause of bowel perforation. It is caused by faecal impaction, which generates pressure against the colon wall, leading to ischaemic necrosis and subsequent perforation. Since diagnosis is often delayed, stercoral perforation is usually mistreated as constipation or faecal impaction, leading to high mortality. This report presents a case of stercoral perforation in a woman aged 34 years who was promptly diagnosed and successfully treated.
February 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28185260/a-comparison-of-sugammadex-and-neostigmine-for-reversal-of-rocuronium-induced-neuromuscular-blockade-in-children
#11
A S Ammar, K M Mahmoud, Z A Kasemy
BACKGROUND: Sugammadex is designed to be a reversal agent for steroidal muscle relaxants. The current trial was aimed to compare between sugammadex and neostigmine concerning the recovery time from neuromuscular blockade. We hypothesised that sugammadex might have shorter recovery time than neostigmine. METHODS: Sixty paediatric patients aged 2-10 years scheduled for lower abdominal surgeries were randomly assigned into two equal groups to receive 4 mg/kg sugammadex (Group S) or 0...
February 10, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28184044/corrigendum-hic1-controls-cellular-and-hiv-1-gene-transcription-via-interactions-with-ctip2-and-hmga1
#12
Valentin Le Douce, Faezeh Forouzanfar, Sebastian Eilebrecht, Benoit Van Driessche, Amina Ait-Ammar, Roxane Verdikt, Yoshihito Kurashige, Céline Marban, Virginie Gautier, Ermanno Candolfi, Arndt G Benecke, Carine Van Lint, Olivier Rohr, Christian Schwartz
No abstract text is available yet for this article.
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28183845/incidence-of-idiopathic-ventricular-arrhythmias-a-population-based-study
#13
Surksha Sirichand, Ammar M Killu, Deepak Padmanabhan, David O Hodge, Alanna M Chamberlain, Peter A Brady, Suraj Kapa, Peter A Noseworthy, Douglas L Packer, Thomas M Munger, Bernard J Gersh, Christopher J McLeod, Win-Kuang Shen, Yong-Mei Cha, Samuel J Asirvatham, Paul A Friedman, Siva K Mulpuru
BACKGROUND: Ventricular tachycardia and premature ventricular complexes (PVCs) most frequently occur in the context of structural heart disease. However, the burden of idiopathic ventricular arrhythmias (IVA) in the general population is unknown. METHODS AND RESULTS: We identified incident cases of IVA between 2005 and 2013 from Olmsted County, Minnesota, using the Rochester Epidemiology Project database. For PVC cohorts, we included those with frequent (defined as ≥100 PVC/24 hours) symptomatic PVCs...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28181667/water-usage-in-the-gaza-strip-recommendations-from-a-literature-review-and-consultations-with-experts
#14
Emily MacDonald, Bernardo Guzman Herrador, Susanne Hyllestad, Vidar Lund, Karin Nygård, Line Vold, Mohamed Lafi, Walaa Ammar, Bjørn Iversen
Water quality in the Gaza Strip has been severely compromised due to increasing salinity, contamination with pollutants, and lack of adequate treatment options. To provide the population of the Gaza Strip with advice on how to mitigate health risks from water we developed recommendations on using water from different sources for different purposes (such as for consumption, hygiene, amenities, and irrigation) based on a literature review and consultation with experts. Specific advice was developed for several vulnerable groups, including infants, children, pregnant or lactating women, and elderly people...
February 1, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/28175451/211%C3%A2-cortical-oscillations-during-memory-encoding-are-reinstated-on-a-faster-time-scale-during-memory-recall
#15
Ammar Shaikhouni, Robert Yaffe, Sara Inati, Kareem A Zaghloul
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28173866/opuntia-ficus-indica-cladodes-as-a-functional-ingredient-bioactive-compounds-profile-and-their-effect-on-antioxidant-quality-of-bread
#16
Lotfi Msaddak, Ola Abdelhedi, Amani Kridene, Mostafa Rateb, Lassaâd Belbahri, Emna Ammar, Moncef Nasri, Nacim Zouari
BACKGROUND: In the context of a balanced diet, the antioxidant-rich food consumption is a preventive way of many degenerative diseases. Consequently, improving the nutraceutical quality of traditional foods such as bakery products is an interesting approach. Considering the present consumer's demand, cladodes from prickly pear that were traditionally used as a valuable food as well as in folk medicine for the treatment of several chronic diseases were investigated for their use in bread production to improve its functionality...
February 7, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28171810/short-versus-long-small-sided-game-training-during-ramadan-in-soccer-players
#17
Hana Baklouti, Noureddine Rejeb, Asma Aloui, Hamdi Jaafar, Achraf Ammar, Hamdi Chtourou, Olivier Girard, Nizar Souissi
OBJECTIVE: To compare the effects of two small-sided game (SSG) training formats (4 × 4 min (SSG-S) and 2 × 8 min (SSG-L)) conducted during Ramadan on Hoff and five-jump (5JT) tests' performances and session rating of perceived exertion (sRPE). DESIGN: Three group, case-control. SETTING: Field tests. PARTICIPANTS: Twenty-four male soccer players were divided into 3 groups: 2 groups undertaking 4 weeks of SSG-S (n = 8) or SSG-L (n = 8) during Ramadan and a control group (n = 8)...
October 24, 2016: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28165822/in-vitro-and-in-vivo-investigation-for-optimization-of-niosomal-ability-for-sustainment-and-bioavailability-enhancement-of-diltiazem-after-nasal-administration
#18
H O Ammar, M Haider, M Ibrahim, N M El Hoffy
Diltiazem hydrochloride (DTZ) is a calcium channel antagonist depicted by extensive first pass metabolism and low oral bioavailability. The aim of this work was to develop niosomes for potential nasal delivery of DTZ. Niosomes protect hydrophilic drugs inside their core while nasal route offers both rapid onset and evasion of first-pass metabolism. Niosomes were prepared using a combination of Span 60 or Brij-52 with cholesterol (CHOL) in different molar ratios followed by determination of entrapment efficiency, particle size and in vitro drug release...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28162871/a-young-female-with-urinary-retention-a-case-report-of-hashimoto-s-encephalopathy
#19
Benjamin L Cooper, Shane E Appel, Hussam M Ammar
Hashimoto's Encephalopathy (HE) is a rare form of autoimmune encephalopathy associated with Hashimoto's thyroiditis in which patients experience cognitive impairment and various neurologic symptoms. We present a case of a young female that presented to the emergency department with urinary retention, and was ultimately diagnosed with HE. Examination was significant for direction-changing and vertical nystagmus (direction-changing nystagmus describes a phenomenon where the fast beat changes with the direction of gaze), hyperreflexia, clonus, and Babinski and Hoffman's reflexes (all upper motor neuron (UMN) signs)...
January 26, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28162058/prevalence-of-epilepsy-in-74-949-school-children-in-khartoum-state-sudan
#20
Inaam N Mohamed, Maha A Elseed, Ahlam A Hamed, Manar E Abdel-Rahman, Sarah M El-Sadig, Ilham M Omer, Abdelgadir H Osman, Ammar E Ahmed, Zein A Karrar, Mustafa A Salih
BACKGROUND: Data on childhood epilepsy in Sudan are scarce and the only published study on its prevalence was published in 1983. This study aimed to determine the current prevalence of epilepsy in school children in Khartoum State. METHODS: This is an analytical population-based, cross-sectional study conducted in Khartoum State, Sudan. The study included students in the basic (primary) schools aged 6-14 years. Simple random sampling was used to draw a cluster of four of the seven localities comprising Khartoum State...
February 6, 2017: Paediatrics and International Child Health
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