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https://www.readbyqxmd.com/read/29775808/phase-ii-study-of-maintenance-pembrolizumab-in-patients-with-extensive-stage-small-cell-lung-cancer-sclc
#1
Shirish M Gadgeel, Nathan A Pennell, Mary Jo Fidler, Balazs Halmos, Philip Bonomi, James Stevenson, Bryan Schneider, Ammar Sukari, Jaclyn Ventimiglia, Wei Chen, Cathy Galasso, Antoinette Wozniak, Julie Boerner, Gregory P Kalemkerian
PURPOSE: To assess the efficacy of maintenance pembrolizumab in extensive-stage small cell lung cancer (SCLC) patients, after treatment with platinum/etoposide. PATIENTS AND METHODS: Extensive-stage SCLC patients with a response or stable disease following induction chemotherapy were eligible. Pembrolizumab at a dose of 200 mg IV every 3 weeks was initiated within 8 weeks of the last cycle of chemotherapy. The primary endpoint of the study was progression-free survival (PFS) from study registration, with overall survival (OS) as a key secondary endpoint...
May 15, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29770754/changing-epidemiology-of-catheter-related-bloodstream-infections-in-cancer-patients
#2
Anne Marie Chaftari, Ray Hachem, Ying Jiang, Pankil Shah, Alawami Hussain, Zainab Al Hamal, Ammar Yousif, Mary Jordan, Majd Michael, Issam Raad
We compared the etiologic organisms of bloodstream infections (BSIs) in cancer patients with central venous catheters (CVCs) between 2 cohorts separated by more than a decade.Gram-negative organisms have become the predominant etiologic organisms of BSIs (52%); they now contribute to 41% of catheter-related BSIs (CRBSIs).Infect Control Hosp Epidemiol 2018;39:727-729.
June 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29767556/hydronephrosis-is-associated-with-elevated-plasmin-in-urine-in-pediatric-patients-and-rats-and-changes-in-ncc-and-%C3%AE-enac-abundance-in-rat-kidney
#3
Rikke Zachar, Ammar Al-Mashhadi, Henrik Dimke, Per Svenningsen, Boye L Jensen, Mattias Carlström
Obstruction of urine flow at the level of the pelvo-ureteric junction (UPJO) and subsequent development of hydronephrosis is one of the most common congenital renal malformations. UPJO is associated with development of salt-sensitive hypertension, which is set by the obstructed kidney, and with a stimulated renin-angiotensin-aldosterone system (RAAS) in rodent models. This study aimed at investigating the hypothesis that i) in pediatric patients with UPJO the RAAS is activated prior to surgical relief of the obstruction; ii) in rats with UPJO the RAAS activation is reflected by increased abundance of renal aldosterone-stimulated Na+ transporters; and iii) the injured UPJO kidney allows aberrant filtration of plasminogen leading to proteolytic activation of the epithelial sodium channel gamma subunit (γ-ENaC)...
May 16, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29766546/therapeutic-interventions-to-lessen-the-psychosocial-effect-of-vitiligo-in-children-a-review
#4
REVIEW
Simi D Cadmus, Ashley D Lundgren, Ammar M Ahmed
Vitiligo commonly affects children, with half of affected individuals experiencing disease onset before the age of 20. Because childhood is a time of advancement in social and psychological development, understanding the extent of the effect of the disease and means of alleviation is crucial. Vitiligo has been shown to decrease children's quality of life, with greater distress in children with highly visible lesions and darker skin tones. This article reviews the literature regarding interventions that have been analyzed in children...
May 16, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29763700/grafting-polymerization-of-acrylic-acid-onto-chitosan-cellulose-hybrid-and-application-of-the-graft-as-highly-efficient-ligand-for-elimination-of-water-hardness-validation-of-high-selectivity-in-presence-of-interfering-ions
#5
Magdy F Mohamed, Xiaojian Zhou, Hanan S Ibrahim, Nabila S Ammar, Hisham A Essawy
Graft Copolymer resulting from polymerization of acrylic acid from chitosan is non-coherent, brittle and exhibit modest swelling in water, which limits its application. Chitosan-cellulose hybrid was initially prepared and novel polymeric ligand ((CTS/Cell)-g-PAA) derived from grafting polymerization of acrylic acid from this hybrid was fabricated and investigated using fourier transform infrared (FTIR) and Scanning electron microscopy (SEM). Also, the graft copolymer exhibited high mass transfer under a wide range of pH values due to its elevated hydrophilicity in addition to a good mechanical strength with respect to the comparable graft derived from chitosan as sole backbone for the grafting...
May 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29759844/novel-electrophysiology-signal-recording-system-improves-signal-acquisition-and-appreciation-of-catheter-contact-force
#6
Ammar M Killu, Deepak Padmanabhan, Kalpathi L Venkatachalam, Samuel J Asirvatham
No abstract text is available yet for this article.
December 26, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29756692/the-presence-of-elastic-compression-stockings-reduces-the-fluid-responsiveness-of-patients-in-the-operating-room
#7
Elie Zogheib, Julien Maizel, Nabil Cherradi, Ammar Benammar, Béatrice Labont, Abdel Hchikat, Michael Bernasinski, Faouzi Trojette, Michel Slama, Hervé Dupont
BACKGROUND: To investigate whether elastic compression stockings (ECS) can affect fluid responsiveness parameters before and during passive leg raising (PLR) maneuvers. METHODS: In the operating room (OR), we performed a prospective study including patients referred for cardiac surgery. Blood pressure (BP), ΔPP, heart rate (HR), central venous pressure (CVP), stroke volume (SV) and aortic blood flow (ABF) (by esophageal doppler) were measured according to four conditions: supine position without ECS (baseline 1), lower limbs raised to an angle of 45° (PLR 1), returned to the supine position with ECS (baseline 2), then a second PLR maneuver with ECS was performed (PLR 2)...
May 11, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29754589/orbital-t-cell-lymphoma-in-youngest-recorded-patient-early-diagnosis-management-and-successful-outcome-a-case-report-and-review-of-the-literature
#8
Hind Manaa Alkatan, Saleh Hamad Alrashed, Ammar C Al-Rikabi, Yasser H Al-Faky
BACKGROUND: Primary orbital peripheral T-cell lymphoma, not otherwise specified is an exceedingly rare disorder with a very poor outcome, and to the best of our knowledge only a few cases have been reported in the English literature. We present the youngest reported case describing the successful outcome after management with a thorough review of the English literature of all the reported cases of primary peripheral T-cell lymphoma, not otherwise specified. CASE PRESENTATION: Our patient is a 3-year-old Syrian boy who presented with gradual progressive orbital swelling...
May 14, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29749260/effectiveness-safety-and-economic-comparison-of-inhaled-flolan-and-veletri-in-cardiothoracic-surgery-patients
#9
Jaclyn M Hawn, Matthew Wanek, Seth R Bauer, Mahmoud A Ammar, Steven Insler, Ahmad Adi, Heather Torbic
BACKGROUND: No previous studies exist examining inhaled Flolan compared with inhaled Veletri in a homogeneous cardiothoracic surgery patient population. OBJECTIVE: To compare the impact of inhaled Flolan and inhaled Veletri on the effectiveness, safety, or cost in cardiothoracic surgery patients. MATERIALS AND METHODS: This was a retrospective, noninferiority study comparing inhaled Flolan and inhaled Veletri in cardiothoracic surgery patients...
May 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29746580/characterization-and-mapping-of-leaf-rust-resistance-in-four-durum-wheat-cultivars
#10
Dhouha Kthiri, Alexander Loladze, P R MacLachlan, Amidou N'Diaye, Sean Walkowiak, Kirby Nilsen, Susanne Dreisigacker, Karim Ammar, Curtis J Pozniak
Widening the genetic basis of leaf rust resistance is a primary objective of the global durum wheat breeding effort at the International Wheat and Maize Improvement Center (CIMMYT). Breeding programs in North America are following suit, especially after the emergence of new races of Puccinia triticina such as BBG/BP and BBBQD in Mexico and the United States, respectively. This study was conducted to characterize and map previously undescribed genes for leaf rust resistance in durum wheat and to develop reliable molecular markers for marker-assisted breeding...
2018: PloS One
https://www.readbyqxmd.com/read/29745362/does-dietary-nitrate-say-no-to-cardiovascular-ageing-current-evidence-and-implications-for-research
#11
Mario Siervo, Filippo Scialò, Oliver M Shannon, Blossom C M Stephan, Ammar W Ashor
CVD are characterised by a multi-factorial pathogenesis. Key pathogenetic steps in the development of CVD are the occurrence of endothelial dysfunction and formation of atherosclerotic lesions. Reduced nitric oxide (NO) bioavailability is a primary event in the initiation of the atherosclerotic cascade. NO is a free radical with multiple physiological functions including the regulation of vascular resistance, coagulation, immunity and oxidative metabolism. The synthesis of NO proceeds via two distinct pathways identified as enzymatic and non-enzymatic...
May 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29742101/buoyancy-effects-in-stagnation-point-flow-of-maxwell-fluid-utilizing-non-fourier-heat-flux-approach
#12
Ammar Mushtaq, Meraj Mustafa, Tasawer Hayat, Ahmed Alsaedi
Here we utilize a non-Fourier approach to model buoyancy aiding or opposing flow of Maxwell fluid in the region of stagnation-point towards a vertical stretchable surface. Flow field is permeated by uniform transverse magnetic field. Two different heating processes namely (i) prescribed surface temperature (PST) and (ii) constant wall temperature (CWT) are analyzed. Through suitable transformations, the similarity equations are formed which are treated numerically for a broad range of magnetic interaction parameter...
2018: PloS One
https://www.readbyqxmd.com/read/29739362/case-report-of-a-novel-homozygous-splice-site-mutation-in-pla2g6-gene-causing-infantile-neuroaxonal-dystrophy-in-a-sudanese-family
#13
Liena E O Elsayed, Inaam N Mohammed, Ahlam A A Hamed, Maha A Elseed, Mustafa A M Salih, Ashraf Yahia, Rayan A Siddig, Mutaz Amin, Mahmoud Koko, Mustafa I Elbashir, Muntaser E Ibrahim, Alexis Brice, Ammar E Ahmed, Giovanni Stevanin
BACKGROUND: Infantile neuroaxonal dystrophy (INAD) is a rare hereditary neurological disorder caused by mutations in PLA2G6. The disease commonly affects children below 3 years of age and presents with delay in motor skills, optic atrophy and progressive spastic tetraparesis. Studies of INAD in Africa are extremely rare, and genetic studies from Sub Saharan Africa are almost non-existent. CASE PRESENTATION: Two Sudanese siblings presented, at ages 18 and 24 months, with regression in both motor milestones and speech development and hyper-reflexia...
May 8, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29731358/a-giant-ovarian-cyst-in-an-adolescent
#14
Francesca Corrias, Federica Pederiva, Giorgio Cozzi, Lydie Ammar, Elisabetta Cattaruzzi, Maria Antonietta Lembo, Egidio Barbi
No abstract text is available yet for this article.
May 3, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29731335/association-between-dairy-consumption-dietary-calcium-intake-and-general-and-abdominal-obesity-among-iranian-adults
#15
Omid Sadeghi, Ammar Hassanzadeh Keshteli, Farideh Doostan, Ahmad Esmaillzadeh, Peyman Adibi
AIM: To assess the association of dairy consumption and dietary calcium intake with general and abdominal obesity in a large sample of Iranian adults. METHODS: In this cross-sectional study, dairy consumption and dietary calcium intake were assessed using a validated dish-based 106-item semi-quantitative food frequency questionnaire in 6582 Iranian adults aged 18-55 years living in Isfahan. A self-administered validated questionnaire was used to collect data on anthropometric measures...
April 25, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29728343/determinants-of-intention-to-use-mobile-phone-caller-tunes-to-promote-voluntary-blood-donation-cross-sectional-study
#16
Bernard Appiah, James N Burdine, Ammar Aftab, Lucy Asamoah-Akuoko, David A Anum, Irene A Kretchy, Elfreda W Samman, Patience B Appiah, Imelda Bates
BACKGROUND: Voluntary blood donation rates are low in sub-Saharan Africa. Sociobehavioral factors such as a belief that donated blood would be used for performing rituals deter people from donating blood. There is a need for culturally appropriate communication interventions to encourage individuals to donate blood. Health care interventions that use mobile phones have increased in developing countries, although many of them focus on SMS text messaging (short message service, SMS). A unique feature of mobile phones that has so far not been used for aiding blood donation is caller tunes...
May 4, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29719933/prospective-evaluation-of-the-effect-of-deferasirox-on-hematologic-response-in-transfusion-dependent-patients-with-low-risk-mds-and-iron-overload
#17
C Rose, C Lenoir, E Gyan, M Hacini, S Amé, B Corront, O Beyne-Rauzy, D Adiko, E Loppinet, N Ali-Ammar, K Laribi, E Wattel, F Dreyfus, C S Roué, S Cheze
OBJECTIVES: To assess the reduction of transfusions rate in transfusion-dependent patients with low-risk myelodysplastic syndrome (MDS) with iron overload treated with deferasirox. METHODS: Prospective observational study. Primary endpoint was reduction in transfusion requirements (RTR) at 3 months, (assessed on 8-week period). Secondary endpoints were hematologic improvement according IWG 2006 criteria at 3, 6, 12 months. RESULTS: Fifty-seven patients were evaluable...
May 2, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29719304/prognostic-value-of-soluble-death-receptor-ligands-in-patients-with-transitional-cell-carcinoma-of-bladder
#18
Islem Ben Bahria-Sediki, Mohamed Chebil, Carla Sampaio, Véronique Martel-Frachet, Mohamed Cherif, Rachida Zermani, Soumaya Rammeh, Amel Ben Ammar Gaaied, Ali Bettaieb
BACKGROUND: The activation of Fas/Fas ligand (FasL) and DR4-DR5/tumor necrosis factor-related-apoptosis-inducing ligand (TRAIL) pathways in cancer cells triggers apoptosis. The objective of this study was to investigate the prognostic value of soluble FasL (sFasL) and soluble (sTRAIL) in the serum of patients with bladder cancer. METHODS: The sFasL and sTRAIL levels in the sera of patients with bladder cancer or healthy donors were determined using the enzyme-linked immunosorbent assay...
May 2, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29708145/utility-of-computed-tomography-lung-cancer-screening-and-the-management-of-computed-tomography-screen-detected-findings
#19
EDITORIAL
Ammar Chaudhry, Maryam Gul, Abbas Chaudhry
No abstract text is available yet for this article.
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29700059/ventricular-electrical-activation-delay-and-high-frequency-electrocardiograms-hype-or-hope
#20
EDITORIAL
Ammar M Killu, Yong-Mei Cha
No abstract text is available yet for this article.
May 2018: Circulation. Arrhythmia and Electrophysiology
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