keyword
https://read.qxmd.com/read/38521740/sequential-transplantation-of-exosomes-and-bmscs-pretreated-with-hypoxia-efficiently-facilitates-perforator-skin-flap-survival-area-in-rats
#21
JOURNAL ARTICLE
Jin-Ping Ding, Yan Sun, Bo Chen, Wen-Jiang Qian, Shi-Wei Bao, Hong-Yi Zhao
Bone marrow mesenchymal stem cells (BMSC) are promising candidates for the treatment of trans-territory perforator flap necrosis. However, the low retention and survival rate of engrafted BMSCs limit their therapeutic efficacy. Strategies either modifying BMSCs or alleviating the inflammatory environment may solve this problem. Thus, we aimed to explore the therapeutic efficacy of sequential transplantation of exosomes and hypoxia pretreated BMSCs on flap necrosis. After the perforator flap model was created, the exosomes derived from BMSCs were injected immediately into choke zone II followed by transplantation of hypoxia pretreated BMSCs on Day 2...
December 28, 2023: British Journal of Oral & Maxillofacial Surgery
https://read.qxmd.com/read/38521627/consensus-of-the-brazilian-association-of-hematology-hemotherapy-and-cellular-therapy-on-patient-blood-management-preoperative-clinical-and-laboratory-assessment-of-the-patient
#22
JOURNAL ARTICLE
Roberto Luiz da Silva, Bruno Deltreggia Benites, Flavia Leite, Selma Soriano, Susankerle de Oliveira Costa Alves, Silvia Renata Cornélio Parolin Rizzo, Guilherme Rabello, Dante Mario Langhi Junior
The preoperative clinical and laboratory evaluations of the patient is an essential step to ensure the safety and success of any surgical procedure. This assessment aims to identify any underlying medical conditions and risk factors and determine suitability for surgery. With this step, the medical team can adapt the care plan to meet each patient's specific needs, increasing the chances of a successful procedure. Good clinical assessment and comprehensive laboratory testing, when integrated into a Patient Blood Management approach, are invaluable in promoting safety of care, reducing transfusion risks, improving surgical outcomes, and optimizing resource utilization...
March 13, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38521626/consensus-of-the-brazilian-association-of-hematology-hemotherapy-and-cellular-therapy-on-patient-blood-management-assessment-and-management-of-coagulation-in-the-preoperative-period
#23
JOURNAL ARTICLE
Flavia Leite, Bruno Deltreggia Benites, Roberto Luiz da Silva, Selma Soriano, Susankerle de Oliveira Costa Alves, Silvia Renata Cornélio Parolin Rizzo, Guilherme Rabello, Dante Mario Langhi Junior
Managing coagulation disorders and potential bleeding risks, especially in the context of anticoagulant medications, is of immense value both clinically and prior to surgery. Coagulation disorders can lead to bleeding complications, affecting patient safety and surgical outcomes. The use of Patient Blood Management protocols offers a comprehensive, evidence-based approach that effectively addresses these challenges. The problem is to find a delicate balance between preventing thromboembolic events (blood clots) and reducing the risk of bleeding...
March 13, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38521411/graft-failure-incidence-risk-factors-and-outcomes-in-patients-undergoing-non-myeloablative-allogeneic-hematopoietic-cell-transplantation-using-post-transplant-cyclophosphamide
#24
JOURNAL ARTICLE
Jonaphine Rae Mata, Marianna Zahurak, Natalie Rosen, Amy E DeZern, Richard J Jones, Alexander J Ambinder
BACKGROUND: Graft failure (GF) is a major complication of allogeneic hematopoietic cell transplantation (alloHCT) that results in significant morbidity and mortality. Post-transplant cyclophosphamide (PTCy)-based graft-versus-host disease (GVHD) prophylaxis has emerged as an effective regimen across the spectrum of donor-match settings, but few studies have investigated the characteristics of GF in the setting of PTCy-based GVHD prophylaxis. OBJECTIVES: The objective was to detail the incidence, clinical features, risk factors, and outcomes for patients with primary graft failure (PGF) and secondary graft failure (SGF)...
March 21, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38520796/eltrombopag-treatment-in-thrombocytopenia-following-hematopoietic-stem-cell-transplantation-a-multicenter-real-world-experience
#25
JOURNAL ARTICLE
Ebru Kilic Gunes, Sureyya Yigit Kaya, Fatih Yaman, Mustafa Kemal Yeniay, Kurtulus Vural, Melda Comert, Omur Gokmen Sevindik, Neslihan Andic, Simten Dagdas, Ilknur Nizam Ozen, Leylagul Kaynar, Filiz Yavasoglu, Gulsum Ozet, Volkan Karakus, Meltem Ayli
INTRODUCTION: Thrombocytopenia is among the most common complications following hematopoietic stem cell transplantation and is associated with increased mortality and morbidity with no standard treatment yet. In this multicenter and retrospective study, we aim to present our multi-center experience of Eltrombopag treatment in patients with isolated thrombocytopenia following HSCT. MATERIAL-METHOD: A total of 73 patients from 5 centers who underwent autologous or allogeneic stem cell transplantation, had no primary disease relapse, all of whom had neutrophil engraftment, complete chimerism, and who were diagnosed with Prolonged Isolated Thrombocytopenia (PIT) or Secondary Failure Of Platelet Recovery (SFPR) were included in the study...
March 15, 2024: Leukemia Research
https://read.qxmd.com/read/38519412/adverse-effects-of-microparticles-on-transfusion-of-stored-red-blood-cell-concentrates
#26
JOURNAL ARTICLE
Jie Yang, Yiming Yang, Li Gao, Xueyu Jiang, Juan Sun, Zhicheng Wang, Rufeng Xie
BACKGROUND: Systemic and pulmonary coagulopathy and inflammation are important characteristics of transfusion-related acute lung injury (TRALI). Whether microparticles that accumulate in transfused red blood cell concentrates (RBCs) have proinflammatory and procoagulant potential and contribute to adverse reactions of RBC transfusions is unclear. AIM: To investigate the ability of microparticles in stored RBCs to promote thrombin generation and induce human pulmonary microvascular endothelial cell (HMVEC) activation and damage...
March 11, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38518684/non-tuberculous-mycobacterial-isolates-from-panama-a-retrospective-5-year-analysis-2017-2021
#27
JOURNAL ARTICLE
Prudencio González, Juan Domínguez, Pedro Del Cid, Samantha Rosas, Ariel Magallón-Tejada
BACKGROUND: The genus Mycobacterium includes well-known bacteria such as M. tuberculosis causing tuberculosis and M. leprae causing leprosy. Additionally, various species collectively termed non-tuberculous mycobacteria (NTM) can cause infections in humans and animals, affecting individuals across all age groups and health conditions. However, information on NTM infection prevalence in Panama is limited. METHODS: This study conducted a retrospective analysis of clinical records from 2017 to 2021, specifically focusing on patients with NTM isolates...
March 5, 2024: Journal of Infection and Public Health
https://read.qxmd.com/read/38518064/lessons-learned-from-ocular-graft-versus-host-disease-an-ocular-surface-inflammatory-disease-of-known-time-of-onset
#28
JOURNAL ARTICLE
Manuel E Quiroga-Garza, Raul E Ruiz-Lozano, Luis A Rodriguez-Gutierrez, Ali Khodor, Symon Ma, Seitaro Komai, Karim Mohamed-Noriega, Victor L Perez
The ocular surface inflammatory disorders (OSIDs) comprise a group of conditions characterized by persistent inflammation of the ocular surface and adnexal tissues. Systemic autoimmune diseases and hypersensitivity reactions cause them, and, if left untreated, can result in severe inflammatory dry eye, corneal damage, and vision loss. Ocular graft-versus-host disease (oGVHD) forms part of the ocular surface inflammatory disease umbrella. It is a condition occurring after allogeneic hematopoietic stem cell or bone marrow transplantation, usually in chronic graft-versus-host disease...
March 22, 2024: Eye & Contact Lens
https://read.qxmd.com/read/38516178/a-scoping-review-exploring-cure-definitions-and-language-for-inherited-hemoglobinopathies
#29
JOURNAL ARTICLE
Marilyn S Baffoe-Bonnie, K Jameson Floyd, Alicia A Livinski, Christine Grady
PURPOSE: Sickle cell disease and beta thalassemia are some of the first targets for potentially curative cell-based therapies. Currently, bone marrow transplants, stem cell transplants, and gene therapy are being researched and utilized for people living with these hemoglobinopathies. Although these therapies are often described as curative, there is not a clear definition of what cure means for these hemoglobinopathies. METHODS: Five databases were searched for this scoping review...
2024: Genet Med Open
https://read.qxmd.com/read/38514814/storage-of-wine-and-blood
#30
EDITORIAL
Shaun R McCann
No abstract text is available yet for this article.
March 21, 2024: Bone Marrow Transplantation
https://read.qxmd.com/read/38514813/transplantation-for-myelofibrosis-patients-in-the-ruxolitinib-era-a-registry-study-from-the-soci%C3%A3-t%C3%A3-francophone-de-greffe-de-moelle-et-de-th%C3%A3-rapie-cellulaire
#31
JOURNAL ARTICLE
Sara Villar, Sylvie Chevret, Xavier Poire, Magalie Joris, Patrice Chevallier, Jean-Henri Bourhis, Edouard Forcade, Sylvain Chantepie, David Beauvais, Nicole Raus, Jacques-Olivier Bay, Michael Loschi, Raynier Devillier, Remy Duléry, Patrice Ceballos, Marie Thérèse Rubio, Sophie Servais, Stephanie Nguyen, Marie Robin
In this SFGM-TC registry study, we report the results after stem cell transplantation (HSCT) in 305 myelofibrosis patients, in order to determine potential risk factors associated with outcomes, especially regarding previous treatment with ruxolitinib. A total of 102 patients were transplanted from an HLA-matched-sibling donor (MSD), and 143 patients received ruxolitinib. In contrast with previous studies, our results showed significantly worse outcomes for ruxolitinib patients regarding overall survival (OS) and non-relapse mortality (NRM), especially in the context of unrelated donors (URD)...
March 21, 2024: Bone Marrow Transplantation
https://read.qxmd.com/read/38514025/fatal-outcome-of-bk-virus-encephalitis-in-an-allogeneic-stem-cell-transplantation-recipient
#32
Kyosuke Yamaguchi, Hisashi Yamamoto, Koji Izutsu, Mitsuhiro Yuasa, Daisuke Kaji, Aya Nishida, Kazuya Ishiwata, Shinsuke Takagi, Go Yamamoto, Yuki Asano-Mori, Naoyuki Uchida, Shuichi Taniguchi
BK virus (BKV) encephalitis is a rare complication after hematopoietic stem cell transplantation (HSCT). A 43-year-old woman with recurrent follicular lymphoma after autologous HSCT received allogeneic bone marrow transplantation from a human leukocyte antigen-matched related donor. Neutrophil engraftment was achieved on post-transplant day 13. Memory loss and noncooperative attitude toward the medical staff were observed on day 16, and her mental status worsened progressively. Magnetic resonance imaging (MRI) showed nonspecific findings on day 19; however, cerebrospinal fluid (CSF) analysis including real-time polymerase chain reaction on day 20 revealed elevated levels of BKV 4...
March 19, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/38513621/co-culture-of-chondrocytes-and-stem-cells-a-review-of-head-and-neck-cell-lines-for-cartilage-regeneration
#33
Michael Fook-Ho Lee, Daniel Steffens, Johnson H Y Chung, Steven Posniak, Kai Cheng, Jonathan Clark, Gordon Wallace, Payal Mukherjee
INTRODUCTION: Bioprinting, using "bio-inks" consisting of living cells, supporting structures and biological motifs to create customized constructs, is an emerging technique that aims to overcome the challenges of cartilaginous reconstruction of head and neck structures. Several living cell lines and culturing methods have been explored as bio-inks with varying efficacy. Co-culture of primary chondrocytes and stem cells (SCs) is one technique, well established for degenerative joint disease treatment, with potential for use in expanding chondrocyte populations for bio-inks...
March 21, 2024: Cells, Tissues, Organs
https://read.qxmd.com/read/38511985/mir96-has-good-potential-to-differentiate-human-bone-marrow-derived-mesenchymal-stem-cells-into-photoreceptor-like-cells
#34
JOURNAL ARTICLE
Mohammad-Reza Mahmoudian-Sani, Najmeh Fattahi, Morteza Hashemzadeh Chaleshtori, Samira Asgharzade
OBJECTIVES: MicroRNAs play an important role in the development and function of neuron cells. Among these, the miRNA known as MIR96 is abundantly expressed in mammalian retina and significantly affects differentiation, maturation, and survival of human photoreceptor cells. In this study, a mimic to miRNA-96 was transfected into human bone marrowderived mesenchymal stem cells to explore the biological functions of MIR96 at differentiation processing. MATERIALS AND METHODS: A mimic to miRNA-96 and a competitive control were transfected into human bone marrow-derived mesenchymal stem cells using Lipofectamine...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38511389/impact-of-donor-nkg2d-and-mica-gene-polymorphism-on-clinical-outcomes-of-adult-and-paediatric-allogeneic-cord-blood-transplantation-for-malignant-diseases
#35
JOURNAL ARTICLE
Steven T Cox, Warren Patterson, Richard Duggleby, Owen J R Jones, J Alejandro Madrigal, Sergi Querol, Francesc Rudilla Salvador, Maria Jose Herrero Mata, Fernanda Volt, Éliane Gluckman, Richard Szydlo, Robert D Danby, Diana Hernandez
OBJECTIVES: NKG2D is an activating receptor expressed by natural killer (NK) and CD8+ T cells and activation intensity varies by NKG2D expression level or nature of its ligand. An NKG2D gene polymorphism determines high (HNK1) or low (LNK1) expression. MICA is the most polymorphic NKG2D ligand and stronger effector cell activation associates with methionine rather than valine at residue 129. We investigated correlation between cord blood (CB) NKG2D and MICA genotypes and haematopoietic stem cell (HSC) transplant outcome...
March 21, 2024: European Journal of Haematology
https://read.qxmd.com/read/38510655/tumor-integrin-targeted-theranostic-iron-oxide-nanoparticles-for-delivery-of-caffeic-acid-phenethyl-ester-preparation-characterization-and-anti-myeloma-activities
#36
JOURNAL ARTICLE
Barkley Smith, Yuancheng Li, Travis Fields, Michael Tucker, Anna Staskiewicz, Erica Wong, Handong Ma, Hui Mao, Xinyu Wang
Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells preferentially in the bone marrow. Currently, emerging chemotherapy drugs with improved biosafety profiles, such as immunomodulatory agents and protease inhibitors, have been used in clinics to treat MM in both initial therapy or maintenance therapy post autologous hematopoietic stem cell transplantation (ASCT). We previously discovered that caffeic acid phenethyl ester (CAPE), a water-insoluble natural compound, inhibited the growth of MM cells by inducing oxidative stress...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38509196/improving-nutritional-status-after-allogeneic-stem-cell-transplantation-results-of-phase-2-allonut-clinical-trial
#37
JOURNAL ARTICLE
Sophie Estran, Michael Loschi, Sami Benachour, Alizée Soldati, Edmond Chiche, Rinzine Sammut, Guillaume Robert, Arnaud Jacquel, Jacques Chibois, Stephane Schneider, Thomas Cluzeau
Malnutrition increases the risk of non-relapse mortality after allogeneic stem cell transplantation (aHSCT). Here are the results of the ALLONUT clinical trial designed to improve the nutritional outcome of patients receiving aHSCT. ALLONUT is a prospective open label phase 2 clinical trial assessing the efficacy of a close tailored nutritional support and management with traditional and original solutions to improve patients nutritional status following aHSCT. Nutritional status evaluation was performed before transplantation, on Day 0, 30, 100 and one year after transplantation...
March 20, 2024: Bone Marrow Transplantation
https://read.qxmd.com/read/38508946/consensus-of-the-brazilian-association-of-hematology-hemotherapy-and-cellular-therapy-on-patient-blood-management
#38
JOURNAL ARTICLE
Juan Carlos Montano-Pedroso, Silvana Biagini, Maria Cristina Martins de Almeida Macedo, Glaciano Ribeiro, José Franciscos Comenalli Marques Junior, Silvia Renata Cornélio Parolin Rizzo, Guilherme Rabello, Dante Mario Langhi Junior
Patient Blood Management (PBM) is a multidimensional approach that seeks to optimize the use of blood and its components in patients. This matter emerged as a response to the need to reduce unnecessary exposure to blood transfusions and their potential risks. In the past, blood transfusion was often overused resulting in complications and high costs. The advent of Patient Blood Management has caused a paradigm shift, highlighting anemia prevention, bleeding control and maximizing the production of blood cells by the organism itself...
March 11, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38506770/ex-vivo-culture-resting-time-impacts-transplantation-outcomes-of-genome-edited-human-hematopoietic-stem-and-progenitor-cells-in-xenograft-mouse-models
#39
JOURNAL ARTICLE
Selami Demirci, Muhammad B N Khan, Gabriela Hinojosa, Anh Le, Alexis Leonard, Khaled Essawi, Bjorg Gudmundsdottir, Xiong Liu, Jing Zeng, Zaina Inam, Rebecca Chu, Naoya Uchida, Daisuke Araki, Evan London, Henna Butt, Stacy A Maitland, Daniel E Bauer, Scot A Wolfe, Andre Larochelle, John F Tisdale
Ex vivo resting culture is a standard procedure following genome editing in hematopoietic stem and progenitor cells (HSPCs). However, prolonged culture may critically affect cell viability and stem cell function. We investigated whether varying durations of culture resting times impact the engraftment efficiency of human CD34+ HSPCs edited at the BCL11A enhancer, a key regulator in the expression of fetal hemoglobin. We employed electroporation to introduce CRISPR-Cas9 components for BCL11A enhancer editing and compared outcomes with nonelectroporated (NEP) and electroporated-only (EP) control groups...
February 24, 2024: Cytotherapy
https://read.qxmd.com/read/38506587/the-management-of-chronic-graft-versus-host-disease-skin-ulcers-after-hematopoietic-stem-cell-transplantation-a-case-report
#40
JOURNAL ARTICLE
Yi Chen, XueHua Zhao, Xun Wang, Lai Juan Li, LinZhu Wu
The comprehensive management of a patient with chronic graft-versus-host disease skin ulcers after hematopoietic stem cell transplantation is challenging. This report describes the case of a 53-year-old woman who presented with ulcers on her right leg 140 weeks after a bone marrow transplant. The patient received wound assessment and management based on the Triangle of Wound Assessment and Wound Bed Preparation 2021, respectively. Hydrogel and antibacterial protease dressings were applied along with systemic oral administration of moxifloxacin hydrochloride (two capsules, two times daily) and JiXueGanPian tablets (classic Chinese herbal formula; two capsules, two times daily), hospital-community-home continuous care, and patient-centered education...
April 1, 2024: Advances in Skin & Wound Care
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