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intracranial atherosclerosis

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https://www.readbyqxmd.com/read/27917937/vessel-wall-differences-between-middle-cerebral-artery-and-basilar-artery-plaques-on-magnetic-resonance-imaging
#1
Peng-Peng Niu, Yao Yu, Hong-Wei Zhou, Yang Liu, Yun Luo, Zhen-Ni Guo, Hang Jin, Yi Yang
A recent study showed that posterior circulation plaques have a greater capacity for positive remodeling in a non-Asian population. We aimed to investigate if the features of plaques in the middle cerebral artery (MCA) were different from those in the basilar artery (BA) in a northern Chinese population. We retrospectively analysed the records of 71 consecutive patients with acute ischemic stroke. All patients had at least one MCA or BA plaque with early or mild (<50% stenosis) atherosclerosis identified using vessel wall magnetic resonance imaging...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27908279/co-existing-intracranial-and-extracranial-carotid-artery-atherosclerotic-plaques-and-recurrent-stroke-risk-a-three-dimensional-multicontrast-cardiovascular-magnetic-resonance-study
#2
Yilan Xu, Chun Yuan, Zechen Zhou, Le He, Donghua Mi, Rui Li, Yuanyuan Cui, Yilong Wang, Yongjun Wang, Gaifen Liu, Zhuozhao Zheng, Xihai Zhao
BACKGROUND: As a systemic disease, atherosclerosis commonly affects intracranial and extracranial carotid arteries simultaneously which is defined as co-existing plaques. Previous studies demonstrated that co-existing atherosclerotic diseases are significantly associated with ischemic cerebrovascular events. The aim of this study was to investigate the characteristics of co-existing intracranial and extracranial carotid atherosclerotic plaques and their relationships with recurrent stroke by using 3D multi-contrast magnetic resonance (MR) vessel wall imaging...
December 2, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27887791/cryptogenic-stroke-and-nonstenosing-intracranial-calcified-atherosclerosis
#3
Hooman Kamel, Gino Gialdini, Hediyeh Baradaran, Ashley E Giambrone, Babak B Navi, Michael P Lerario, James K Min, Costantino Iadecola, Ajay Gupta
OBJECTIVE: Because some cryptogenic strokes may result from large-artery atherosclerosis that goes unrecognized as it causes <50% luminal stenosis, we compared the prevalence of nonstenosing intracranial atherosclerotic plaques ipsilateral to cryptogenic cerebral infarcts versus the unaffected side using imaging biomarkers of calcium burden. METHODS: In a prospective stroke registry, we identified patients with cerebral infarction limited to the territory of one internal carotid artery (ICA)...
November 23, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27852711/angioplasty-and-stenting-for-patients-with-symptomatic-intracranial-atherosclerosis-study-protocol-of-a-randomised-controlled-trial
#4
Xiao-Ping Cui, Min Lin, Jun-Shan Mu, Jian-Xin Ye, Wen-Qing He, Mao-Lin Fu, Hua Li, Jia-Yang Fang, Feng-Feng Shen, Hang Lin
INTRODUCTION: Whether adding percutaneous transluminal angioplasty and stenting (PTAS) to background medical treatment is effective for decreasing the incidence of stroke or death in patients with symptomatic intracranial atherosclerosis (ICAS) is still controversial. We perform a randomised controlled trial to examine the effectiveness and safety of an improved PTAS procedure for patients with ICAS. METHODS AND ANALYSIS: A randomised controlled trial will be conducted in three hospitals in China...
November 15, 2016: BMJ Open
https://www.readbyqxmd.com/read/27843693/treatment-and-imaging-of-intracranial-atherosclerotic-stenosis-current-perspectives-and-future-directions
#5
REVIEW
Ido R van den Wijngaard, Ghislaine Holswilder, Marianne A A van Walderveen, Ale Algra, Marieke J H Wermer, Osama O Zaidat, Jelis Boiten
BACKGROUND AND PURPOSE: Intracranial atherosclerosis is a common cause of stroke worldwide. It results in ischemic stroke due to different mechanisms including artery-to-artery embolism, in situ thrombo-occlusion, occlusion of perforating arteries, and hemodynamic failure. In this review, we present an overview of current treatment and imaging modalities in intracranial atherosclerotic stenosis. METHODS: PubMed was searched for relevant articles in English that evaluated the treatment and imaging of intracranial atherosclerotic stenosis (ICAS)...
November 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27836652/intracranial-vessel-wall-imaging-for-evaluation-of-steno-occlusive-diseases-and-intracranial-aneurysms
#6
REVIEW
Waleed Brinjikji, Mahmud Mossa-Basha, John Huston, Alejandro A Rabinstein, Giuseppe Lanzino, Vance T Lehman
Cerebrovascular diseases have traditionally been classified, diagnosed and managed based on their luminal characteristics. However, over the past several years, several advancements in MRI techniques have ushered in high-resolution vessel wall imaging (HR-VWI), enabling evaluation of intracranial vessel wall pathology. These advancements now allow us to differentiate diseases which have a common angiographic appearance but vastly different natural histories (i.e. moyamoya versus atherosclerosis, reversible cerebral vasoconstriction syndrome versus vasculitis, stable versus unstable intracranial aneurysms)...
November 8, 2016: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/27820930/is-there-benefit-from-stenting-on-cognitive-function-in-intracranial-atherosclerosis
#7
Tanya N Turan, Alison Smock, George Cotsonis, David Bachman, Sami Al Kasab, Michael J Lynn, Azhar Nizham, Collin P Derdeyn, David Fiorella, Scott Janis, Bethany Lane, Jean Montgomery, Marc I Chimowitz
BACKGROUND: Revascularization of stenotic cerebral arteries is hypothesized to improve cognition by increasing cerebral perfusion. AIMS: We compared cognition impairment among patients treated with percutaneous angioplasty and stenting (PTAS) and aggressive medical management (AMM) versus AMM alone in the Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis (SAMMPRIS) Trial. METHODS: In SAMMPRIS, 451 patients with recent transient ischemic attack or stroke attributed to 70-99% intracranial stenosis were randomized to PTAS plus AMM or AMM alone...
November 5, 2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27818028/high-extent-of-intracranial-carotid-artery-calcification-is-associated-with-downstream-microemboli-in-stroke-patients
#8
Xiao-Hong Wu, Xiang-Yan Chen, Yu-Hua Fan, Thomas Wai-Hong Leung, Ka-Sing Wong
BACKGROUND: Intracranial arterial calcification (ICAC) is frequently detected on head computed tomography and has been found to be associated with ischemic stroke by recent clinical studies. AIMS: Based on a hospital-based study, we aimed to compare the occurrence of cerebral microembolic signals (MES) among stroke patients with different degrees of ICAC, which may indicate the potential mechanisms linking ICAC and ischemic stroke in intracranial atherosclerosis patients...
November 3, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27811134/impact-of-modified-tici-3-versus-modified-tici-2b-reperfusion-score-to-predict-good-outcome-following-endovascular-therapy
#9
C Dargazanli, A Consoli, M Barral, J Labreuche, H Redjem, G Ciccio, S Smajda, J P Desilles, G Taylor, C Preda, O Coskun, G Rodesch, M Piotin, R Blanc, B Lapergue
BACKGROUND AND PURPOSE: The TICI score is widely used to evaluate cerebral perfusion before and after the endovascular treatment of stroke. Recent studies showing the effectiveness and safety of mechanical thrombectomy combine modified TICI 2b and modified TICI 3 to assess the technical success of endovascular treatment. The purpose of this study was to determine how much clinical outcomes differ between patients achieving modified TICI 2b and modified TICI 3 reperfusion. MATERIALS AND METHODS: We analyzed 222 consecutive patients with acute large intracranial artery occlusion of the anterior circulation having achieved modified TICI 2b or modified TICI 3 reperfusion after thrombectomy...
November 3, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27805576/protocol-for-isolating-the-mouse-circle-of-willis
#10
Justine Claire Hur, Régis Blaise, Isabelle Limon
The cerebral arterial circle (circulus arteriosus cerebri) or circle of Willis (CoW) is a circulatory anastomosis surrounding the optic chiasma and hypothalamus that supplies blood to the brain and surrounding structures. It has been implicated in several cerebrovascular disorders, including cerebral amyloid angiopathy (CAA)-associated vasculopathies, intracranial atherosclerosis and intracranial aneurysms. Studies of the molecular mechanisms underlying these diseases for the identification of novel drug targets for their prevention require animal models...
October 22, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27796172/risk-factors-between-intracranial-extracranial-atherosclerosis-and-anterior-posterior-circulation-stroke-in-ischaemic-stroke
#11
Yan Li, Yefeng Cai, Min Zhao, Jingbo Sun
OBJECTIVES: Atherosclerosis is an important cause of stroke and remains a challenge for stroke prevention. Risk factors involved in atherosclerotic stroke and anterior and posterior circulation strokes (ACS and PCS, respectively) are different. The purpose of this study is to investigate differences in risk factors between intracranial and extracranial atherosclerosis (ICAS and ECAS), ACS and PCS, and ICAS/ECAS with ACS/PCS in a Chinese acute ischaemic stroke population. METHODS: We analysed 551 ischaemic stroke patients who had been enrolled between August 2005 and July 2008...
October 31, 2016: Neurological Research
https://www.readbyqxmd.com/read/27790125/a-case-of-turner-syndrome-with-multiple-embolic-infarcts
#12
Cindy W Yoon, Eungseok Lee, Byung-Nam Yoon, Hee-Kwon Park, Joung-Ho Rha
Only a few cases of Turner syndrome (TS) with ischemic stroke have been reported. Various arteriopathies of the cerebral arteries, including fibromuscular dysplasia, congenital hypoplasia, moyamoya syndrome, and premature atherosclerosis have been assumed to be the cause of ischemic stroke in TS. There has been no case report of a TS patient presenting with an embolic stroke pattern without any cerebral arteriopathy. A 28-year-old woman with TS was referred to our hospital because of abnormal brain magnetic resonance imaging (MRI) findings...
September 2016: Case Reports in Neurology
https://www.readbyqxmd.com/read/27760401/relation-of-serum-homocysteine-levels-to-cerebral-artery-calcification-and-atherosclerosis
#13
Jeong-Min Kim, Kwang-Yeol Park, Dong-Woo Shin, Moo-Seok Park, Oh-Sang Kwon
BACKGROUND AND AIMS: Elevated serum homocysteine level is known to be associated with increased risk of vascular event due to endothelial senescence. We investigated the association between serum homocysteine level and cerebral arteriosclerosis status including intracranial vascular calcification and atherosclerosis burden. METHODS: We identified 1193 consecutive patients (mean age = 68.6 ± 12.7, 537 female patients) who were admitted with acute cerebral infarction or transient ischemic attack from a single university medical center...
November 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27649736/incidence-predictors-and-etiology-of-subsequent-ischemic-stroke-within-one-year-after-transient-ischemic-attack
#14
Toshiyuki Uehara, Kazuo Minematsu, Tomoyuki Ohara, Kazumi Kimura, Yasushi Okada, Yasuhiro Hasegawa, Norio Tanahashi, Akifumi Suzuki, Shigeharu Takagi, Jyoji Nakagawara, Kazumasa Arii, Shinji Nagahiro, Kuniaki Ogasawara, Shinichiro Uchiyama, Masayasu Matsumoto, Koji Iihara, Kazunori Toyoda
BACKGROUND: Incidence and predictors of ischemic stroke in patients with transient ischemic attack (TIA) have not been fully clarified outside Europe and North America. AIMS: We undertook the present prospective, multicenter study to clarify the incidence, predictors, and etiology of ischemic stroke within one year of TIA onset in Japan. METHODS: The study subjects were patients within seven days of TIA onset who were enrolled in a prospective register from 57 hospitals between June 2011 and December 2013...
September 20, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27637638/temporary-steno-occlusive-change-in-the-donor-artery-during-mouth-opening-big-bite-ischemic-phenomenon-after-superficial-temporal-artery-to-middle-cerebral-artery-bypass-in-adult-patients-with-moyamoya-disease-and-atherosclerosis
#15
Hiroshi Abe, Toshiro Katsuta, Koichi Miki, Toshio Higashi, Tooru Inoue
BACKGROUND: Superficial temporal artery (STA) to middle cerebral artery (MCA) bypass is one of the most common surgical procedures performed for direct extracranial (EC) to intracranial (IC) bypasses. We describe a temporary steno-occlusive change in the STA that was caused by mouth opening after the STA-MCA bypass (so-called big bite ischemic phenomenon) in an adult patient with moyamoya disease. The aim of this study was to assess the incidence of this phenomenon in patients with atherosclerosis...
2016: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/27634960/histopathologic-analysis-of-cerebral-autosomal-recessive-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy-carasil-a-report-of-a-new-genetically-confirmed-case-and-comparison-to-2-previous-cases
#16
Shinji Ito, Masaki Takao, Toshio Fukutake, Hiroyuki Hatsuta, Sayaka Funabe, Nobuo Ito, Yutaka Shimoe, Toshiro Niki, Imaharu Nakano, Masashi Fukayama, Shigeo Murayama
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a nonhypertensive hereditary cerebral small vessel disease that is caused by mutations in a single gene, HTRA1 The HTRA1 protein normally represses transforming growth factor-β (TGF-β) signaling and its mutations result in vascular changes. Ten homozygous, 1 compound heterozygous, and 1 homozygous frameshift mutation have been identified in the HTRA1 gene of patients with genetically confirmed CARASIL...
September 15, 2016: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/27610123/fractional-flow-assessment-for-the-evaluation-of-intracranial-atherosclerosis-a-feasibility-study
#17
ZhongRong Miao, David S Liebeskind, WaiTing Lo, LiPing Liu, YueHua Pu, XinYi Leng, LiGang Song, XiaoTong Xu, BaiXue Jia, Feng Gao, DaPeng Mo, Xuan Sun, Lian Liu, Ning Ma, Bo Wang, YiLong Wang, YongJun Wang
PURPOSE: Current studies on endovascular intervention for intracranial atherosclerosis select patients based on luminal stenosis. Coronary studies demonstrated that fractional flow measurements assess ischemia better than anatomical stenosis and can guide patient selection for intervention. We similarly postulated that fractional flow can be used to assess ischemic stroke risk. METHODS: This was a feasibility study to assess the technical use and safety of applying a pressure guidewire to measure fractional flow across intracranial stenoses...
June 2016: Interventional Neurology
https://www.readbyqxmd.com/read/27592246/moyamoya-syndrome-causing-stroke-in-young-women-with-type-1-diabetes
#18
Jing W Hughes, Jennifer A Wyckoff, Abby S Hollander, Colin P Derdeyn, Janet B McGill
CONTEXT: Moyamoya syndrome is an idiopathic brain vasculopathy characterized by stenosis of major intracranial arteries. It often presents in patients with type 1 diabetes or thyroid disease and may have an autoimmune etiology. Moyamoya-related stroke poses a diagnostic challenge as initial symptoms and deficits vary greatly from classic ischemic stroke to encephalopathy, psychiatric, or seizure disorder. CASE DESCRIPTION: We report 4 patients with type 1 diabetes and other autoimmune diseases who developed moyamoya-related stroke at a young age...
November 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27589527/vascular-contributions-in-alzheimer-s-disease-related-neuropathological-changes-first-autopsy-evidence-from-a-south-asian-aging-population
#19
Printha Wijesinghe, S K Shankar, T C Yasha, Catherine Gorrie, Dhammika Amaratunga, Sanjayah Hulathduwa, K Sunil Kumara, Kamani Samarasinghe, Yoo-Hun Suh, Harry W M Steinbusch, K Ranil D De Silva
BACKGROUND: Evidence from various consortia on vascular contributions has been inconsistent in determining the etiology of sporadic Alzheimer's disease (AD). OBJECTIVE: To investigate vascular risk factors and cerebrovascular pathologies associated in manifestation of AD-related neuropathological changes of an elderly population. METHODS: Postmortem brain samples from 76 elderly subjects (≥50 years) were used to study genetic polymorphisms, intracranial atherosclerosis of the circle of Willis (IASCW), and microscopic infarcts in deep white matters...
October 18, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27585640/clinical-interpretation-of-high-resolution-vessel-wall-mri-of-intracranial-arterial-diseases
#20
Vance T Lehman, Waleed Brinjikji, David F Kallmes, John Huston, Giuseppe Lanzino, Alejandro A Rabinstein, Ashima Makol, Mahmud Mossa-Bosha
Intracranial arterial pathology has traditionally been evaluated with luminal imaging. Recently, high-resolution vessel wall imaging (HR-VWI) with MRI has facilitated submillimetre evaluation of the arterial walls. This technique can help differentiate various causes of intracranial steno-occlusive disease, identify culprit atherosclerotic plaques with a recent cerebral infarct, locate vessel wall pathology in areas with minimal or no narrowing on luminal imaging, predict aneurysm stability and identify a ruptured aneurysm when multiple aneurysms are present...
November 2016: British Journal of Radiology
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