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https://www.readbyqxmd.com/read/29770267/role-of-noninvasive-imaging-of-cerebral-arterial-system-in-ischemic-stroke-comparison-of-transcranial-color-coded-doppler-sonography-with-magnetic-resonance-angiography
#1
Betty Simon, Sunithi Elizabeth Mani, Shyamkumar Nidugala Keshava, Mathew Alexander, Sanjith Aaron
Aim: To determine the accuracy of transcranial color-coded Doppler sonography (TCCS) in the evaluation of cerebral arterial system in patients with ischemic stroke attending a tertiary care hospital in South India. Objectives: (1) To describe the topographical distribution of atherosclerotic lesions in the cerebral circulation in patients presenting with ischemic stroke from the Indian subcontinent and (2) to determine the accuracy of TCCS for detection and quantification of intracranial stenoses in various segments of the intracerebral arterial system in comparison with magnetic resonance angiography (MRA)...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29766771/five-year-risk-of-stroke-after-tia-or-minor-ischemic-stroke
#2
Pierre Amarenco, Philippa C Lavallée, Linsay Monteiro Tavares, Julien Labreuche, Gregory W Albers, Halim Abboud, Sabrina Anticoli, Heinrich Audebert, Natan M Bornstein, Louis R Caplan, Manuel Correia, Geoffrey A Donnan, José M Ferro, Fernando Gongora-Rivera, Wolfgang Heide, Michael G Hennerici, Peter J Kelly, Michal Král, Hsiu-Fen Lin, Carlos Molina, Jong Moo Park, Francisco Purroy, Peter M Rothwell, Tomas Segura, David Školoudík, P Gabriel Steg, Pierre-Jean Touboul, Shinichiro Uchiyama, Éric Vicaut, Yongjun Wang, Lawrence K S Wong
Background After a transient ischemic attack (TIA) or minor stroke, the long-term risk of stroke and other vascular events is not well known. In this follow-up to a report on 1-year outcomes from a registry of TIA clinics in 21 countries that enrolled 4789 patients with a TIA or minor ischemic stroke from 2009 through 2011, we examined the 5-year risk of stroke and vascular events. Methods We evaluated patients who had had a TIA or minor stroke within 7 days before enrollment in the registry. Among 61 sites that participated in the 1-year outcome study, we selected 42 sites that had follow-up data on more than 50% of their enrolled patients at 5 years...
May 16, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29749361/risk-factors-for-ruptured-intracranial-aneurysms
#3
Guang-Xian Wang, Dong Zhang, Zhi-Ping Wang, Liu-Qing Yang, Hua Yang, Wen Li
Background & objectives: The treatment of unruptured intracranial aneurysms (IAs) remains controversial; the ability to predict the risk of rupture for an aneurysm would be of clinical value. The aim of this study was to determine and evaluate the predictive value of the risk factors of IA rupture. Methods: This retrospective study involved 379 consecutive patients with 441 aneurysms between August 2011 and July 2014. Based on clinical data and computed tomography angiography findings, the potential of risk factors to predict the aneurysmal rupture was assessed using statistical methods...
January 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29725179/diagonal-earlobe-crease-revealing-intracranial-atherosclerosis
#4
Oscar H Del Brutto, Aldo F Costa
No abstract text is available yet for this article.
April 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29661647/which-ischemic-stroke-subtype-is-associated-with-hyperhomocysteinemia
#5
Levent Gungor, Murat Polat, Mehlika Berra Ozberk, Bahattin Avci, Ummet Abur
BACKGROUND: Stroke is still a major global health problem in both developed and developing countries. Defining stroke subtype and underlying etiologies is a major step to choose the best method for prophylaxis. Homocysteine is an endothelial toxin and elevated levels have been associated with stroke risk. In this study, we hypothesized that serum total homocysteine level may be related with specific atherothrombotic ischemic stroke subtypes and aimed to find if high serum homocysteine levels are correlated with any specific ischemic stroke subtype...
April 13, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29629297/influences-of-pinpoint-plantar-long-wavelength-infrared-light-irradiation-stress-free-therapy-on-chorioretinal-hemodynamics-atherosclerosis-factors-and-vascular-endothelial-growth-factor
#6
Keisou Ishimaru, Takuma Nakajima, Yoshihisa Namiki, Kenji Ryotokuji
Background: We previously reported that pinpoint plantar long-wavelength infrared light irradiation (stress-free therapy; SFT) is useful for alleviating insulin resistance and improving intracranial blood flow in patients with type 2 diabetes mellitus. This study was undertaken to evaluate the influences of SFT on chorioretinal hemodynamics (retinal artery and vein blood flows) as well as atherosclerosis-related factors (TG, LDL-C) and VEGF in patients with dyslipidemia. Methods: Four patients with dyslipidemia received 15-minute irradiation with a stress-free apparatus (far-infrared wavelength, 30 mW)...
March 2018: Integrative Medicine Research
https://www.readbyqxmd.com/read/29614647/reduced-cerebrovascular-reserve-capacity-as-a-biomarker-of-microangiopathy-in-alzheimer-s-disease-and-mild-cognitive-impairment
#7
Barbora Soukupova Urbanova, Jaroslava Paulasova Schwabova, Hana Magerova, Petr Jansky, Hana Markova, Martin Vyhnalek, Jan Laczo, Jakub Hort, Ales Tomek
BACKGROUND: Cerebral microangiopathy in Alzheimer's disease (AD) causes chronic hypoperfusion and probably accelerates neurodegenerative changes. OBJECTIVE: We hypothesize microvascular impairment could be present already in mild cognitive impairment (MCI) and can be revealed using transcranial color-coded sonography (TCCS) and the breath-holding maneuver. METHODS: Three groups of subjects (AD in the stage of dementia, MCI, and cognitively normal controls) with detailed neuropsychological testing and low cerebrovascular burden (no history of stroke, no intra- or extracranial artery stenoses, and no severe vascular lesions on brain MRI), underwent a TCCS assessment of peak systolic (PSV), mean flow (MFV), and end diastolic velocities (EDV) and resistance and pulsatility indices (RI, PI) in large intracranial vessels bilaterally...
March 24, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29601146/quantification-of-near-wall-hemodynamic-risk-factors-in-large-scale-cerebral-arterial-trees
#8
Mahsa Ghaffari, Ali Alaraj, Xinjian Du, Xiaohong Joe Zhou, Fady T Charbel, Andreas A Linninger
In the last decade, detailed hemodynamic analysis of blood flow in pathological segments close to aneurysm and stenosis has provided physicians with invaluable information about the local flow patterns leading to vascular disease. However, these diseases have both local and global effects on the circulation of the blood within the cerebral tree. The aim of this paper is to demonstrate the importance of extending subject-specific hemodynamic simulations to the large-scale cerebral arterial tree with hundreds of bifurcations and vessels, as well as evaluate hemodynamic risk factors and waveform shape characteristics throughout the cerebral arterial trees...
March 30, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29576013/omega-3-fatty-acid-supplement-reduces-activation-of-nadph-oxidase-in-intracranial-atherosclerosis-stenosis
#9
Jiamei Shen, Radhika Rastogi, Longfei Guan, Fengwu Li, Huishan Du, Xiaokun Geng, Yuchuan Ding
Objectives Intracranial atherosclerotic stenosis (ICAS) is one of the most common causes of stroke worldwide. We adapted a rat model of atherosclerosis to study brain intracranial atherosclerosis, and further investigated how omega-3 fatty acids (O3FA) attenuated the development of ICAS by reducing the generation of reactive oxygen species (ROS) and the activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) activity. Methods Adult male Sprague-Dawley rats were divided into control normal-cholesterol or high-cholesterol diet groups with or without O3FA for up to 6 weeks...
March 24, 2018: Neurological Research
https://www.readbyqxmd.com/read/29567985/trends-in-stroke-subtypes-and-vascular-risk-factors-in-a-stroke-center-in-china-over-10-years
#10
Danyang Tian, Qiong Yang, Quan Dong, Nan Li, Bernard Yan, Dongsheng Fan
Rapid economic development in China has caused marked changes in people's lifestyles and medical technology. Exploration of stroke subtype trends is necessary to provide physicians with vital insight for early diagnosis and treatment. We included stroke patients admitted from 2006 to 2015. Trends in stroke subtypes and vascular risk factors were investigated. There were 5521 patients, including 4534 (82.1%) ischemic stroke (IS), 813 (14.7%) intracerebral hemorrhage (ICH) and 174 (3.2%) subarachnoid hemorrhage (SAH) patients...
March 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29567291/ct-angiography-evaluation-of-risk-factors-for-unstable-intracranial-aneurysms
#11
Guang-Xian Wang, Ming-Fu Gong, Li Wen, Lan-Lan Liu, Jin-Bo Yin, Chun-Mei Duan, Dong Zhang
PURPOSE: To evaluate risk factors for the instability in intracranial aneurysms (IAs) using computed tomography angiography (CTA). METHODS: A total of 614 consecutive patients with 661 IAs were reviewed from August 2011 to February 2016. Patients and IAs were divided into stable and unstable groups. In addition to clinical characteristics, IAs characteristics were evaluated by CTA. Multiple logistic regression analysis was used to identify the independent risk factors associated with unstable IAs...
March 19, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29562864/primary-angioplasty-and-stenting-may-be-superior-to-thrombectomy-for-acute-atherosclerotic-large-artery-occlusion
#12
Dong Yang, Min Lin, Shuiping Wang, Huaiming Wang, Yonggang Hao, Wenjie Zi, Penghua Lv, Dequan Zheng, Guodong Xiao, Gelin Xu, Yunyun Xiong, Xinfeng Liu
Objective The objective of this article is to compare the effectiveness of primary angioplasty and/or stenting with stent retriever thrombectomy in acute anterior large-vessel occlusion due to atherosclerotic disease. Methods Patients were retrospectively reviewed from the endovascular treatment for acute anterior circulation ischemic stroke registry. Patients with large-vessel occlusions due to atherosclerosis were selected. We evaluated modified Rankin Scale (mRS) score at 90 days, modified thrombolysis in cerebral infarction (mTICI) score immediately post-procedure, and symptomatic and asymptomatic intracranial hemorrhage within 72 hours...
January 1, 2018: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29560373/inflammatory-mediator-expression-within-retrieved-clots-in-acute-ischemic-stroke
#13
Byung Hyun Baek, Hyung Seok Kim, Woong Yoon, Yun Young Lee, Jang Mi Baek, Eun Hee Kim, Seul Kee Kim
Objective: In this study we investigate the association between the expression of inflammatory mediators measured in clots retrieved by mechanical thrombectomy, stroke etiology, and the susceptibility vessel sign (SVS) on gradient-echo (GRE) MR imaging in acute ischemic stroke patients. Methods: We performed molecular analysis of intracranial clots retrieved by mechanical thrombectomy from 82 patients with acute stroke. Seventy-two of these patients underwent GRE imaging before endovascular therapy...
March 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29550646/metabolic-profiling-of-intra-and-extracranial-carotid-artery-atherosclerosis
#14
Dina Vojinovic, Sven J van der Lee, Cornelia M van Duijn, Meike W Vernooij, Maryam Kavousi, Najaf Amin, Ayşe Demirkan, M Arfan Ikram, Aad van der Lugt, Daniel Bos
BACKGROUND AND AIMS: Increasing evidence shows that intracranial carotid artery atherosclerosis may develop under the influence of a differential metabolic risk factor profile than atherosclerosis in the extracranial part of the carotid artery. To further elucidate these differences, we investigated associations of a wide range of circulating metabolites with intracranial and extracranial carotid artery atherosclerosis. METHODS: From the population-based Rotterdam Study, blood samples from 1111 participants were used to determine a wide range of metabolites by proton nuclear magnetic resonance (NMR)...
March 8, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29543130/effects-of-cerebral-small-vessel-disease-on-the-outcome-of-patients-with-ischemic-stroke-caused-by-large-artery-atherosclerosis
#15
Hui Zhu, Zhixing Li, Jinglei Lv, Renliang Zhao
OBJECTIVE: Cerebral small vessel disease (CSVD) describes a syndrome of neuroimaging, pathological, and associated clinical features caused by small intracranial vascular lesions, which commonly coexists with large artery atherosclerosis (LAA) and has been identified as a major cause of motor impairment over time. In this review, we aim to summarize the relationship between CSVD and LAA, and discuss the effects of CSVD on the clinical outcome of patients with ischemic stroke caused by LAA...
March 15, 2018: Neurological Research
https://www.readbyqxmd.com/read/29530459/high-resolution-magnetic-resonance-imaging-confirmed-atherosclerosis-of-an-intracranial-penetrating-artery-a-case-report
#16
Bing Yang, Huili Zhu, Yusheng Zhang, Anding Xu
Intracranial branch atheromatous disease is an atheromatous pathophysiological process associated with occlusion or stenosis at the orifice of a deep penetrating artery. However, apart from autopsy, atherosclerosis in the penetrating artery has not been confirmed in vivo. In this case, we confirmed that the ostium was located in the parent artery plaque and demonstrated the atherosclerosis of the proximal penetrating artery by using high-resolution magnetic resonance imaging. HR-MRI can be used to identify the pathological changes in penetrating arteries and provides more reliable basic information for the clinical subclassification and optimal medical treatment of penetrating artery infarction...
March 9, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29527887/immunological-vascular-metabolic-and-autonomic-changes-seen-with-aging-possible-implications-for-poor-outcomes-in-the-elderly-following-decompressive-hemicraniectomy-for-malignant-mca-stroke-a-critical-review
#17
Luke Mugge, Tarek R Mansour, Brianna Krafcik, Travis Mazur, Tonya Floyd-Bradstock, Azedine Medhkour
Stroke is one of the leading causes of mortality and morbidity worldwide and requires rapid and intensive treatment to prevent adverse outcomes. Decompressive hemicraniectomy stands as the gold standard for surgical resolution of the intracranial swelling which accompanies cerebral infarction; however, the benefits of this procedure are not as well achieved in the elderly (age >65 yoa) compared to the younger population. This is a critical review performed on all available literature relating to middle cerebral artery (MCA) stroke in the elderly with emphasis on articles examining causality of adverse outcomes in this group over younger populations...
March 8, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29523643/cognitive-impairment-and-intracranial-atherosclerotic-stenosis-in-general-population
#18
M Fareed K Suri, Jincheng Zhou, Ye Qiao, Haitao Chu, Adnan I Qureshi, Tom Mosley, Rebecca F Gottesman, Lisa Wruck, A Richey Sharrett, Alvaro Alonso, Bruce A Wasserman
OBJECTIVE: To investigate the association between asymptomatic intracranial atherosclerosis and cognitive impairment in the Atherosclerosis Risk in Communities (ARIC) cohort. METHODS: ARIC participants underwent high-resolution 3T magnetic resonance angiography and a neuropsychology battery and neurologic examination adjudicated by an expert panel to detect mild cognitive impairment (MCI) and dementia. We adjusted for demographic and vascular risk factors in weighted logistic regression analysis, accounting for stratified sampling design and attrition, to determine the association of intracranial atherosclerotic stenosis (ICAS) with cognitive impairment...
April 3, 2018: Neurology
https://www.readbyqxmd.com/read/29518536/the-prevalence-and-distribution-of-occlusive-lesions-of-the-cerebral-arteries-in-patients-undergoing-coronary-artery-bypass-graft-surgery
#19
Tomohiro Tsunekawa, Motoshi Sawada, Takayoshi Kato, Yusuke Motoji, Tatsuomi Kinoshita, Akihiro Hirakawa, Yasuhide Okawa, Shinji Tomita
Intracranial cerebral atherosclerosis is a significant predictor of stroke after coronary artery bypass grafting (CABG). However, there is limited information on intracranial occlusive lesions in patients undergoing CABG. The purpose of the study was to elucidate the precise prevalence and distribution of occlusive lesions of the extracranial and intracranial arteries in patients undergoing CABG. Between 2009 and 2016, 205 patients underwent preoperative magnetic resonance angiography and elective CABG. The prevalence and the distribution of occlusive lesions were retrospectively examined by preoperative magnetic resonance angiography...
March 5, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29495218/-difference-of-one-year-death-and-stroke-recurrence-in-ischemic-stroke-patients-with-anterior-and-posterior-circulation-intracranial-atherosclerosis
#20
Y H Pu, X Y Zou, Y L Wang, Y S Pan, X L Xiang, A X Soo, H K Leung, X Q Zhao, C X Wang, J X Wong, Y J Wang, L P Liu
Objective: To explore the differences of one year death and stroke recurrence between ischemic stroke patients with intracranial atherosclerotic stenosis or occlusion of anterior circulation and those of posterior circulation. Methods: All the patients were from the Chinese Intracranial Atherosclerosis Study (CICAS), between October 2007 and June 2009; patients with extracranial stenosis or occlusion, patients without acute infarction by diffusion weighted image, and patients with intracranial atherosclerosis of both anterior and posterior circulation were excluded...
February 13, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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