keyword
https://read.qxmd.com/read/38503511/incidence-and-predictors-of-restenosis-following-successful-recanalization-of-non-acute-internal-carotid-artery-occlusion-in-252-cases
#21
JOURNAL ARTICLE
Guangdong Lu, Junqing Wang, Tao Wang, Xinjuan Xu, Xin Li, Xinyi Sun, Zhengyu Wang, Jichang Luo, Yan Ma, Bin Yang, Peng Gao, Yabing Wang, Yanfei Chen, Sheng Liu, Liqun Jiao
BACKGROUND: Data concerning restenosis following successful recanalization of non-acute internal carotid artery occlusion (ICAO) are scarce. This study was conducted to identify the incidence and predictors of restenosis following successful recanalization of non-acute ICAO. METHODS: We reviewed the incidence of restenosis (defined as >70% restenosis or reocclusion) among 252 consecutive patients with successful recanalization of non-acute ICAO. Baseline, imaging, and surgery-related characteristics were analyzed to assess their association with restenosis...
March 19, 2024: Journal of Neurointerventional Surgery
https://read.qxmd.com/read/38500667/influence-of-intestinal-microbial-metabolites-on-the-abscopal-effect-after-radiation-therapy-combined-with-immune-checkpoint-inhibitors
#22
JOURNAL ARTICLE
Hannah Felchle, Julia Gissibl, Laura Lansink Rotgerink, Sophie M Nefzger, Caroline N Walther, Vincent R Timnik, Stephanie E Combs, Julius C Fischer
BACKGROUND: Most clinical studies failed to elicit a strong antitumor immune response and subsequent systemic tumor regression after radiation therapy (RT), even in combination with the immune checkpoint inhibitors (ICI) anti-CTLA4 or anti-PD1. Mechanistically, type I interferon (IFN-I) activation is essential for the development of such abscopal effects (AE); however, mechanisms driving or limiting IFN-I activation are ill defined. Groundbreaking discoveries have shown that antibiotics (ABx) can affect oncological outcomes and that microbiota-derived metabolites can modulate systemic antitumor immunity...
May 2024: Clinical and Translational Radiation Oncology
https://read.qxmd.com/read/38499080/endovascular-outcomes-for-anterior-choroidal-artery-aneurysms-systematic-review-and-meta-analysis
#23
JOURNAL ARTICLE
Yigit Can Senol, Atakan Orscelik, Basel Musmar, Sherief Ghozy, Gokce Belge Bilgin, Hassan Kobbeisi, Madonna Pekkam, David F Kallmes, Ramanathan Kadirvel
BACKGROUND: Anterior choroidal artery (AchoA) aneurysms are relatively rare compared to other types of aneurysms. However, the occurrence of transient or permanent occlusion of the choroidal artery during endovascular or surgical treatment is an uncommon but potentially serious complication. In this study, we aim to investigate the safety and efficacy profile of endovascular treatment (EVT) for AchoA aneurysms. METHODS: The primary outcome of interest was angiographic and clinical outcomes...
March 16, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38498749/shedding-light-on-cardiac-excitation-in-vitro-and-in-silico-analysis-of-native-ca-2-channel-activation-in-guinea-pig-cardiomyocytes-using-organic-photovoltaic-devices
#24
JOURNAL ARTICLE
Theresa Rienmuller, Niroj Shrestha, Mathias Polz, Sara Stoppacher, Daniel Ziesel, Ludovico Migliaccio, Brigitte Pelzmann, Petra Lang, Klaus Zorn-Pauly, Sonja Langthaler, Aleksandar Opancar, Christian Baumgartner, Muammer Ucal, Rainer Schindl, Vedran Derek, Susanne Scheruebel
OBJECTIVE: This study aims to explore the potential of organic electrolytic photocapacitors (OEPCs), an innovative photovoltaic device, in mediating the activation of native voltage-gated Cav1.2 channels (ICa,L) in Guinea pig ventricular cardiomyocytes. METHODS: Whole-cell patch-clamp recordings were employed to examine light-triggered OEPC mediated ICa,L activation, integrating the channel's kinetic properties into a multicompartment cell model to take intracellular ion concentrations into account...
March 18, 2024: IEEE Transactions on Bio-medical Engineering
https://read.qxmd.com/read/38497864/independent-predictors-of-true-positivity-of-positive-myocardial-perfusion-imaging
#25
JOURNAL ARTICLE
F Koca, G Özmen
UNLABELLED: OBJECTIVE: The primary aim of the present study was to determine the success of single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) in detecting critical coronary artery disease (CAD) as identified by invasive coronary angiography (ICA), as well as to compare the positive predictive values (PPV) of different stress methods. Our secondary aim was to investigate demographic, laboratory, electrocardiographic, and echocardiographic variables that could predict true positive results...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497180/middle-cerebral-artery-ischemic-complications-after-flow-diverter-deployment-from-internal-carotid-artery-extending-into-m1-segment
#26
JOURNAL ARTICLE
Eyup Baykara, Abdullah Topcu, Ozkan Celiker
AIM: To gain a better understanding of ischemia risk related to in-stent stenosis (ISS) or in-stent thrombosis (IST) of the middle cerebral artery (MCA) and lenticulostriate arteries after flow-diverting devices (FDD) deployment from the internal carotid artery (ICA) to proximal middle cerebral artery (M1). MATERIAL AND METHODS: Using data from a prospectively maintained database, we retrospectively evaluated patients who were treated with FDD between January 2015 and 2020 at a single academic center...
2024: Turkish Neurosurgery
https://read.qxmd.com/read/38497124/comparison-of-normocalcemic-versus-hypercalcemic-primary-hyperparathyroidism-in-a-hypercalciuric-renal-stone-population
#27
JOURNAL ARTICLE
Halimi Caroline, Bor Clemence, Chieze Remi, Saint-Jacques Camille, Périé Sophie, Wagner Isabelle, Talbot Jean-Noel, Montravers Françoise, Letavernier Emmanuel, Buob David, Daudon Michel, Frochot Vincent, Haymann Jean-Philippe
CONTEXT: Primary hyperparathyroidism (PHPT) is commonly diagnosed in the setting of hypercalcemia, whereas normocalcemic primary hyperparathyroidism (NHPT) may be misdiagnosed. OBJECTIVE: Our objective was to compare hypercalcemic hyperparathyroidism (HPHPT) versus NHPT hypercalciuric renal stone patients. DESIGN AND SETTING: We took advantage of a routine calcium load test performed in hypercalciuric renal stone patients to assess retrospectively among PHPT patients, prevalence and characteristics of NHPT and HPHPT under a calcium restricted diet...
March 18, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38496124/when-hearts-and-minds-collide-a-case-report-of-left-ventricle-noncompaction-syndrome-as-a-precursor-to-acute-ischemic-stroke-in-a-15-year-old-along-with-a-literature-review
#28
Yousif Alkhafaji, Omar Farooq Al-Nahhas, Khaled Alaboud Alkheder, Jamal A Alkoteesh
Pediatric stroke, though uncommon, is often underdiagnosed due to subtle symptoms and delayed recognition. Cardiac diseases, accounting for up to 33% of pediatric ischemic strokes, play a significant role. This case report explores the rare occurrence of ischemic stroke in a 15-year-old boy with left ventricular non-compaction syndrome (LVNC). It underscores the complexity of managing pediatric ischemic stroke, particularly in the context of LVNC, emphasizing the challenges in timely diagnosis and management...
February 2024: Curēus
https://read.qxmd.com/read/38495242/ct-angiographic-patterns-predict-carotid-pseudo-occlusion-in-acute-ischemic-stroke
#29
JOURNAL ARTICLE
Sayooja Sachithanandan, Harikrishnan Ramachandran, E R Jayadevan, Santhosh K Kannath, Sapna E Sreedharan, P N Sylaja
BACKGROUND: Identifying carotid pseudo-occlusion (PO) from true occlusion (TO) has implications in determining the candidacy and feasibility of successful endovascular thrombectomy (EVT) in acute ischemic stroke (AIS). PURPOSE: We reviewed the computed tomography angiographic (CTA) patterns differentiating a PO from a TO and analyzed the rate of successful recanalization after EVT. MATERIALS AND METHODS: Patients with AIS and proximal internal carotid artery (ICA) occlusion who underwent EVT from 2014 to 2021 were identified...
2024: Annals of Indian Academy of Neurology
https://read.qxmd.com/read/38492542/amygdala-functional-connectivity-in-borderline-personality-disorder
#30
JOURNAL ARTICLE
Laila Noor, Jonas Hoffmann, Tina Meller, Christian Gaser, Igor Nenadić
Borderline personality disorder (BPD) is characterised by structural and functional brain alterations. Yet, there is little data on functional connectivity (FC) across different levels of brain networks and parameters. In this study, we applied a multi-level approach to analyse abnormal functional connectivity. We analysed resting-state functional magnetic resonance imaging (fMRI) data sets of 69 subjects: 17 female BPD patients and 51 age-matched psychiatrically healthy female controls. fMRI was analysed using CONN toolbox including: a) seed-based FC analysis of amygdala connectivity, b) independent component analysis (ICA) based network analysis of intra- and inter-network FC of selected resting-state networks (DMN, SN, FPN), as well as c) graph-theory based measures of network-level characteristics...
March 11, 2024: Psychiatry Research. Neuroimaging
https://read.qxmd.com/read/38491231/smart-splitting-merging-assisted-reliable-independent-component-analysis-for-extracting-accurate-brain-functional-networks
#31
JOURNAL ARTICLE
Xingyu He, Vince D Calhoun, Yuhui Du
Functional networks (FNs) hold significant promise in understanding brain function. Independent component analysis (ICA) has been applied in estimating FNs from functional magnetic resonance imaging (fMRI). However, determining an optimal model order for ICA remains challenging, leading to criticism about the reliability of FN estimation. Here, we propose a SMART (splitting-merging assisted reliable) ICA method that automatically extracts reliable FNs by clustering independent components (ICs) obtained from multi-model-order ICA using a simplified graph while providing linkages among FNs deduced from different-model orders...
March 15, 2024: Neuroscience Bulletin
https://read.qxmd.com/read/38490583/impact-of-the-day-night-cycle-on-functional-connectome-in-ageing-male-and-female-mice
#32
JOURNAL ARTICLE
Houéfa Armelle Lokossou, Giovanni Rabuffo, Monique Bernard, Christophe Bernard, Angèle Viola, Teodora-Adriana Perles-Barbacaru
To elucidate how time of day, sex, and age affect functional connectivity (FC) in mice, we aimed to examine whether the mouse functional connectome varied with the day/night cycle and whether it depended on sex and age. We explored C57Bl6/J mice (6♀ and 6♂) at mature age (5 ± 1 months) and middle-age (14 ± 1 months). Each mouse underwent Blood Oxygen-Level-Dependent (BOLD) resting-state functional MRI (rs-fMRI) on a 7T scanner at four different times of the day, two under the light condition and two under the dark condition...
March 13, 2024: NeuroImage
https://read.qxmd.com/read/38489544/efficacy-and-safety-of-tirofiban-before-stenting-for-symptomatic-intracranial-atherosclerotic-stenosis-a-randomized-clinical-trial
#33
RANDOMIZED CONTROLLED TRIAL
Jun Zhang, Xin Huang, Guoqing Wang, Xianjun Wang, Tao Zhang, Dong Wang, Lifeng Qi, Jiye Liang, Bing Li, Jianfeng Chu, Kai Li, Lili Sun, Yun Song, Wei Zhao, Meimei Zheng, Yao Meng, Hao Yin, Wei Wang, Ju Han
BACKGROUND AND OBJECTIVES: Acute stent thrombosis (AST) is not uncommon and even catastrophic during intracranial stenting angioplasty in patients with symptomatic high-grade intracranial atherosclerotic stenosis (ICAS). The purpose of this study was to investigate whether adjuvant intravenous tirofiban before stenting could reduce the risk of AST and periprocedural ischemic stroke in patients receiving stent angioplasty for symptomatic ICAS. METHODS: A prospective, multicenter, open-label, randomized clinical trial was conducted from September 9, 2020, to February 18, 2022, at 10 medical centers in China...
April 9, 2024: Neurology
https://read.qxmd.com/read/38489331/venous-blood-gases-and-electrolyte-values-of-captive-red-foot-tortoise-chelonoidis-carbonarius
#34
JOURNAL ARTICLE
Sofia Silva La Rocca de Freitas, Laís Velloso Garcia, Jairo Antonio Melo Dos Santos, Líria Queiroz Luz Hirano
Blood gas analysis reflects the exchange of oxygen and carbon dioxide in the lungs. This test provides important information, since the relationship between these gases has a direct impact on the acid-basic balance in the body. Given the significance of blood gas analysis in Brazilian reptiles, this study set out to establish temperature-corrected and uncorrected reference intervals for venous blood gas measurements in Chelonoidis carbonarius, and to compare values between females and males. In this study, 19 animals were used, 8 males and 11 females...
2024: PloS One
https://read.qxmd.com/read/38489035/hemodynamic-impairments-of-evaluating-symptomatic-intracranial-atherosclerotic-stenosis-using-quantitative-flow-ratio-on-digital-subtraction-angiography-a%C3%A2-comparison-with-computed-tomography-perfusion-mri-and-fractional-flow-reserve
#35
JOURNAL ARTICLE
Yingchun Wu, Feng Gao, Honglin Feng
PURPOSE: Cerebral hemodynamics are important for the management of intracranial atherosclerotic stenosis (ICAS). The quantitative flow ratio (QFR) is a novel angiography-derived index for assessing the functional relevance of ICAS without pressure wires and adenosine. Good diagnostic yield with the hyperemic fractional flow reserve (FFR) have been reported, while data on the comparison of QFR to FFR are scarce. METHODS: In this prospective study 56 patients with anterior circulation symptomatic ICAS who received endovascular treatment were included...
March 15, 2024: Clinical Neuroradiology
https://read.qxmd.com/read/38489034/hemorrhage-at-high-altitude-impact-of-sustained-hypobaric-hypoxia-on-cerebral-blood-flow-tissue-oxygenation-and-tolerance-to-simulated-hemorrhage-in-humans
#36
JOURNAL ARTICLE
Alexander J Rosenberg, Garen K Anderson, Haley J McKeefer, Jordan Bird, Brandon Pentz, Britta R M Byman, Nicholas Jendzjowsky, Richard J Wilson, Trevor A Day, Caroline A Rickards
With ascent to high altitude (HA), compensatory increases in cerebral blood flow and oxygen delivery must occur to preserve cerebral metabolism and consciousness. We hypothesized that this compensation in cerebral blood flow and oxygen delivery preserves tolerance to simulated hemorrhage (via lower body negative pressure, LBNP), such that tolerance is similar during sustained exposure to HA vs. low altitude (LA). Healthy humans (4F/4 M) participated in LBNP protocols to presyncope at LA (1130 m) and 5-7 days following ascent to HA (3800 m)...
March 15, 2024: European Journal of Applied Physiology
https://read.qxmd.com/read/38488284/myrf-a-unique-transmembrane-transcription-factor-from-proteolytic-self-processing-to-its-multifaceted-roles-in-animal-development
#37
REVIEW
Yingchuan B Qi, Zhimin Xu, Shiqian Shen, Zhao Wang, Zhizhi Wang
The Myelin Regulator Factor (MYRF) is a master regulator governing myelin formation and maintenance in the central nervous system. The conservation of MYRF across metazoans and its broad tissue expression suggest it has functions extending beyond the well-established role in myelination. Loss of MYRF results in developmental lethality in both invertebrates and vertebrates, and MYRF haploinsufficiency in humans causes MYRF-related Cardiac Urogenital Syndrome, underscoring its importance in animal development; however, these mechanisms are largely unexplored...
March 15, 2024: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://read.qxmd.com/read/38486275/association-between-triglyceride-glucose-index-and-intracranial-extracranial-atherosclerotic-stenosis-findings-from-a-retrospective-study
#38
JOURNAL ARTICLE
Yu Xie, Kuan Cen, Bitang Dan, Li Zou, Lei Zhang, Renwei Zhang, Huagang Li, Qi Cai, Nadire Aiziretiaili, Zhenxing Liu, Yumin Liu
OBJECTIVE: The association of the triglyceride-glucose (TyG) index with intracranial atherosclerotic stenosis (ICAS) and extracranial atherosclerotic stenosis (ECAS) is unclear. This study aimed to investigate the relationship of TyG index with the distribution and severity of ICAS and ECAS. METHOD: Patients who underwent digital subtraction angiography (DSA) for evaluating ICAS/ECAS in Zhongnan Hospital of Wuhan University from January 2017 to October 2021 were retrospectively enrolled in our study...
March 14, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38484969/the-displacement-patterns-of-petrous-ica-and-its-morphometric-relations-with-vidian-canal-in-petroclival-chondrosarcomas-relevant-to-extended-endoscopic-endonasal-approaches-a-radiological-study
#39
JOURNAL ARTICLE
Devnandan Misra, Amandeep Kumar, Leve Joseph
PURPOSE: Extended endoscopic endonasal approaches (EEAs) to petroclival chondrosarcomas (PCs) require a thorough understanding of skullbase anatomy, especially the anatomy of petrous ICA (pICA), as ICA injury is the most dreaded complication of extended EEAs. We conducted this study to determine the displacement patterns of pICA in patients with PCs. METHODS: CECT & angiography images of patients with PCs were analyzed for following parameters -antero-posterior (AP), cranio-caudal (CC), medio-lateral (ML) & direct distances between anterior genu of pICA (AGpICA) and posterior end of vidian canal (pVC)...
March 12, 2024: World Neurosurgery
https://read.qxmd.com/read/38483214/calcium-trafficking-and-gastrointestinal-physiology-following-an-acute-lipopolysaccharide-challenge-in-pigs
#40
JOURNAL ARTICLE
J Opgenorth, E J Mayorga, M A Abeyta, B M Goetz, S Rodriguez-Jimenez, A D Freestone, C H Stahl, L H Baumgard
The influence of systemic immune activation on whole-body Ca trafficking and gastrointestinal tract (GIT) physiology are not clear. Thus, study objectives were to characterize the effects of lipopolysaccharide (LPS) on Ca pools and GIT dynamics to increase understanding of immune-induced hypocalcemia, ileus and stomach hemorrhaging. Twelve crossbred pigs [44 ± 3 kg body weight (BW)] were randomly assigned to 1 of 2 intramuscular treatments: (1) control (CON; 2 mL saline; n=6) or (2) LPS (40 µg LPS/kg BW; n=6)...
March 14, 2024: Journal of Animal Science
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