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cytoreductive surgery, HIPEC

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https://www.readbyqxmd.com/read/28637567/the-impact-of-early-recurrence-on-quality-of-life-after-cytoreduction-with-hipec
#1
Nathan M Hinkle, Vandana Botta, John P Sharpe, Paxton Dickson, Jeremiah Deneve, Gitonga Munene
Improved oncological outcomes after cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in highly selected patients have been well documented. The extensive nature of the procedure adversely affects quality of life (QoL). The aim of this study is to longitudinally evaluate QoL following CRS/HIPEC. This is a retrospective review of a prospectively maintained database of patients with peritoneal malignancies undergoing CRS/HIPEC. Clinicopathological data, oncologic outcomes, and QoL were analyzed preoperatively and postoperatively at 2 weeks, and 1, 3, 6, and 12 months...
June 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28633580/platinum-agents-and-mitomycin-c-specific-complications-in-cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec
#2
Grace Hwei Ching Tan, Nicholas B Shannon, Claramae Shulyn Chia, Khee Chee Soo, Melissa Ching Ching Teo
INTRODUCTION: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been found to prolong survival in patients with peritoneal disease but is associated with significant morbidity. We evaluate the perioperative complications and the association with the chemotherapy agent used for HIPEC. METHODS: Retrospective analysis of a prospectively collected database of CRS-HIPEC cases between April 2001 and February 2016 was performed. Patients were stratified by the chemotherapy used, and perioperative complications were compared...
June 20, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28628712/hyperthermic-intraperitoneal-chemoperfusion-as-a-component-of-multimodality-therapy-for-ovarian-and-primary-peritoneal-cancer
#3
Deepa Magge, Lekshmi Ramalingam, Yongli Shuai, Robert P Edwards, James F Pingpank, Steven S Ahrendt, Matthew P Holtzman, Herbert J Zeh, David L Bartlett, Haroon A Choudry
BACKGROUND AND OBJECTIVES: The role of hyperthermic intraperitoneal chemoperfusion (HIPEC) in the multimodality treatment of ovarian peritoneal metastases (OPM) and primary peritoneal cancer (PPC) remains controversial. We hypothesized that cytoreductive surgery (CRS) and HIPEC would provide meaningful survival benefit without excessive morbidity. METHODS: We reviewed clinicopathologic and perioperative data following 96 CRS-HIPEC procedures for primary or recurrent OPM and PPC...
June 19, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28624046/failure-to-rescue-following-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#4
Kevin Y Li, Ali A Mokdad, Rebecca M Minter, John C Mansour, Michael A Choti, Mathew M Augustine, Patricio M Polanco
BACKGROUND: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) can significantly improve the survival in selected patients with peritoneal carcinomatosis. This study aims to identify perioperative patient characteristics predictive of failure to rescue (FTR), mortality following postoperative complications from CRS/HIPEC. METHODS: Patients suffering a complication following CRS/HIPEC between 2005 and 2013 were identified in the American College of Surgeons National Surgical Quality Improvement Program data set...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28622839/water-lavage-as-an-adjunct-to-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-crs-hipec
#5
Emmanuel Gabriel, Smit Singla, Minhyung Kim, Daniel Fisher, Colin Powers, Anthony Visioni, Kristopher Attwood, Joseph Skitzki
BACKGROUND: Water lavage (WL) during gastrointestinal cancer surgery has osmotically mediated lytic effects on tumor cells. We investigated the safety and efficacy of WL with CRS-HIPEC. METHODS: This is a retrospective review, 1/2003-7/2014, of a single institution experience with CRS-HIPEC comparing patients who had WL (WL+) to those who did not (WL-). RESULTS: Of 157 CRS-HIPECs, 16 (10.2%) were WL+. WL+ had more PCI scores >20 compared to WL- (56...
June 6, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28608388/interval-between-cytoreductions-as-a-marker-of-tumor-biology-in-selecting-patients-for-repeat-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy
#6
Ioannis T Konstantinidis, Edward A Levine, Konstantinos Chouliaras, Gregory Russell, Perry Shen, Konstantinos I Votanopoulos
BACKGROUND AND OBJECTIVES: Repeat cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for recurrence of peritoneal surface malignancies is safe and effective. Patient selection and factors associated with a favorable outcome are still evolving. METHODS: A prospectively maintained institutional database consisting of 1314 CRS/HIPEC procedures performed between February 1993 and December 2015 was reviewed. Clinicopathologic data from 103 patients and 112 (8...
June 12, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28607791/benign-multicystic-peritoneal-mesothelioma-a-rare-condition-in-an-uncommon-gender
#7
Muhammad S Khurram, Hamadullah Shaikh, Uqba Khan, Jacob Edens, Warda Ibrar, Ameer Hamza, Awais Zaka, Roohi Bano, Tarik Hadid
Benign Multicystic Peritoneal Mesothelioma (BMPM) is a rare condition that arises from the abdominal peritoneum. Fewer than 200 cases have been reported worldwide. BMPM usually affects premenopausal women and is extremely rare in men. Many factors are suspected to contribute to its development, such as previous surgery, endometriosis, and familial Mediterranean fever. The main management is surgical resection; however, it is estimated that the recurrence rate is up to 50%. Malignant transformation is rare. We report a case series of three male patients who were diagnosed with BMPM and were treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28594258/first-line-chemotherapy-with-pemetrexed-plus-cisplatin-for-malignant-peritoneal-mesothelioma
#8
Eriko Fujimoto, Takashi Kijima, Kozo Kuribayashi, Yoshiki Negi, Shingo Kanemura, Koji Mikami, Hiroshi Doi, Kazuhiro Kitajima, Takashi Nakano
BACKGROUND: Mesothelioma of peritoneal origin has wider variation in treatment outcomes than mesothelioma of pleural origin, likely because peritoneal mesothelioma comprises borderline malignant variants and aggressive malignant peritoneal mesothelioma (MPeM). This study retrospectively evaluates the efficacy of first-line systemic pemetrexed and cisplatin chemotherapy in MPeM. RESEARCH DESIGN AND METHODS: Twenty-four patients with histologically proven MPeM were treated with pemetrexed plus cisplatin as a first-line systemic chemotherapy...
June 15, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28579603/rapamycin-treatment-for-benign-multicystic-peritoneal-mesothelioma-a-rare-disease-with-a-difficult-management
#9
Giovanni Stallone, Barbara Infante, Luigi Cormio, Luca Macarini, Giuseppe Grandaliano
BACKGROUND Benign multicystic peritoneal mesothelioma (BMPM) is a rare intra-abdominal tumor. Although considered by many to be benign, this tumor has a high local recurrence rate. Because of its rarity, preoperative diagnosis is difficult and its origin and pathogenesis are uncertain. There are no evidence-based treatment strategies for BMPM. It is agreed that the best treatment strategy for BMPM is the combination of surgical cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC). An increasing body of evidence supports a pivotal role of the cytoplasmic serine/threonine kinase mTOR in the development and progression of several neoplastic diseases and specific mTOR inhibitors, including rapamycin, have been suggested as potential therapeutic options for different cancers...
June 5, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28562119/cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-for-peritoneal-malignancy-preliminary-results-of-a-multi-disciplinary-teamwork-model-in-asia
#10
Ting-Yao Wang, Chao-Yu Chen, Chang-Hsien Lu, Min-Chi Chen, Li-Wen Lee, Tzu-Hao Huang, Meng-Chiao Hsieh, Chih-Jung Chen, Chung-Ming Yu, Huei-Chieh Chuang, Tzu-Ting Liao, Chih-Wen Tseng, Wen-Shih Huang
BACKGROUND: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is an emerging surgical procedure for peritoneal carcinomatosis (PC). CRS/HIPEC is a complicated treatment that requires multi-disciplinary teamwork (MDT) which may be lacking when establishing a CRS/HIPEC program. Herein, we report our preliminary treatment outcomes with the early implementation of an MDT model for CRS/HIPEC. METHODS: From April 2015 to December 2016, 45 patients with a diagnosis of PC who received CRS/HIPEC were reviewed retrospectively in a single institution in Taiwan...
May 31, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28560703/allogenic-blood-transfusion-is-an-independent-predictor-of-poorer-peri-operative-outcomes-and-reduced-long-term-survival-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-a-review-of-936-cases
#11
Akshat Saxena, Sarah J Valle, Winston Liauw, David L Morris
INTRODUCTION: There is a paucity of data on the impact of allogenic blood transfusion (ABT) on morbidity and survival outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). METHODS: Nine hundred and thirty-five consecutive CRS/HIPEC procedures were performed between 1996 and 2016 at a high-volume institution in Sydney, Australia. Of these, 337(36%) patients required massive ABT (MABT) (≥5 units). Peri-operative complications were graded according to the Clavien-Dindo classification...
May 30, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28560593/base-excess-as-a-predictor-of-complications-in-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy
#12
Oliver S Eng, Sinziana Dumitra, Michael O'Leary, Mark Wakabayashi, Thanh H Dellinger, Ernest S Han, Stephen J Lee, I Benjamin Paz, Gagandeep Singh, Byrne Lee
BACKGROUND: Base excess is important in assessing metabolic status. Postoperative management in patients undergoing cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal malignancies can be a challenge, and we therefore sought to investigate perioperative predictors of overall morbidity in CRS/HIPEC patients at our institution. METHODS: Patients who underwent CRS/HIPEC from 2012 to 2016 were identified retrospectively from a prospectively collected institutional database...
May 30, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28540833/registries-on-peritoneal-surface-malignancies-through-out-the-world-their-use-and-their-options
#13
Victor J Verwaal, Beate Rau, Faek Jamali, François Noël Gilly, Heikki Takala, Ignace de Hingh, Ingvar Syk, Jorg Pelz, Jurgen Mulsow, Kurt van der Speeten, Shigeki Kusamura, Lene Iversen, Faheez Mohamed, Olivier Glehen, Rami Younan, Roman Yarema, Santiago Gonzalez-Moreno, Sarah O'Dwyer, Yukata Yonemura, Paul Sugarbaker
The treatment of peritoneal surface malignancies ranges from palliative care to full cytoreductive surgery (CRS) and Heated Intraperitoneal Chemotherapy HIPEC. Ongoing monitoring of patient recruitment and volume is usually carried out through dedicated registries. With multiple registries available worldwide, we sought to investigate the nature, extent and value of existing worldwide CRS and HIPEC registries. METHODS: A questionnaire was sent out to all known major treatment centres...
April 9, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540832/concerning-ct-features-used-to-select-patients-for-treatment-of-peritoneal-metastases-a-pictoral-essay
#14
Paul H Sugarbaker, Armando Sardi, Gina Brown, Clarisse Dromain, Pascal Rousset, James S Jelinek
BACKGROUND: During the Fifth International Workshop on Peritoneal Surface Malignancy in Milan in 2008, a consensus was reached that contrast-enhanced CT (ceCT) was the principal imaging modality for patients being evaluated for treatment of peritoneal metastases. This fact being accepted, the radiologic criteria for that may exclude patients from a high value cytoreductive surgery (CRS) plus hyperthermic perioperative chemotherapy (HIPEC) have not been reliably determined. METHODS: From a consensus of surgeons and radiologists, radiologic images were selected and their determinant radiologic characteristics described...
April 9, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540830/progress-in-the-management-of-primary-and-recurrent-ovarian-carcinomatosis-with-peritonectomy-procedure-and-hipec-in-a-high-volume-center
#15
A Arjona-Sanchez, S Rufián-Peña
INTRODUCTION: The treatment of advanced primary or recurrent ephitelial ovarian cancer still remains an open and a critical question. The addition of HIPEC to cytoreductive surgery has showed improving overall survival rates. The aim of our study is to describe the progress in its management in our Unit and what we have learned after more than 350 HIPEC procedures. METHODS: From 1997 to 2016 we conducted a retrospective analysis from a prospective database. We described and analyzed 4 cut-points, 1997-2004, 2009, 2012 and 2016...
March 29, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540829/pseudomyxoma-peritonei-natural-history-and-treatment
#16
Rohin Mittal, Anuradha Chandramohan, Brendan Moran
Pseudomyxoma peritonei (PMP) is an uncommon disease characterized by mucinous ascites, classically originating from a ruptured low grade mucinous neoplasm of the appendix. The natural history of PMP revolves around the "redistribution phenomenon", whereby mucinous tumour cells accumulate at specific sites with relative sparing of the motile small bowel and to a lesser extent other parts of the gastrointestinal tract. Peritoneal tumour accumulates due to gravity and at the sites of peritoneal fluid absorption, namely, the greater and lesser omentum and the under-surface of the diaphragm, particularly on the right...
March 29, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540827/complete-cytoreductive-surgery-plus-hipec-for-peritoneal-metastases-from-unusual-cancer-sites-of-origin-results-from-a-worldwide-analysis-issue-of-the-peritoneal-surface-oncology-group-international-psogi
#17
Diane Goéré, Guillaume Passot, Maximiliano Gelli, Edward A Levine, David L Bartlett, Paul H Sugarbaker, Olivier Glehen
AIM: The aim of this study was to assess the outcomes of patients operated on for peritoneal metastases from unusual cancer sites of origin, meaning apart from PM from colorectal, gastric and epithelial ovarian carcinomas, pseudomyxoma peritonei and mesothelioma. PATIENTS AND METHODS: A questionnaire concerning patients treated with CRS plus HIPEC for PM arising from unusual cancer sites of origin was sent to all centers that routinely performed HIPEC, through the Peritoneal Surface Oncology Group International and the RENAPE network...
March 8, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540826/drugs-doses-and-durations-of-intraperitoneal-chemotherapy-standardizing-hipec-and-epic-for-colorectal-appendiceal-gastric-ovarian-peritoneal-surface-malignancies-and-peritoneal-mesothelioma
#18
Lieselotte Lemoine, Paul Sugarbaker, Kurt Van der Speeten
Peritoneal surface malignancy (PSM) is a common manifestation of digestive and gynecologic malignancies alike. At present, patients with isolated PSM are treated with a combination therapy of cytoreductive surgery (CRS) and hyperthermic peroperative intraperitoneal chemotherapy (HIPEC). The combination of CRS and intraperitoneal (IP) chemotherapy should now be considered standard of care for PSM from appendiceal epithelial cancers, colorectal cancer and peritoneal mesothelioma. Although there is a near universal standardization regarding the CRS, we are still lacking a much-needed standardization amongst the various IP chemotherapy treatment modalities used today in clinical practice...
February 8, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540790/hyperthermic-chemotherapy-intra-abdominal-laparoscopic-approach-development-of-a-laparoscopic-model-using-co2-recirculation-system-and-clinical-translation-in-peritoneal-carcinomatosis
#19
Susana Sánchez-García, David Padilla-Valverde, Pedro Villarejo-Campos, Esther P García-Santos, Jesús Martín-Fernández
INTRODUCTION: Hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective treatment for peritoneal carcinomatosis (PC). Laparoscopic surgery is performed in the treatment of colorectal and appendiceal cancer, and PC from diverse origin in selected patients. HIPEC management by laparoscopic approach after cytoreductive surgery (CRS) completed locoregional treatment of PC, and may be feasible and safe after appropriate patient selection. OBJECTIVE: Development of an experimental model of HIPEC by laparoscopic approach, with CO2 recirculation...
April 2, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540777/acute-kidney-injury-in-ovarian-cancer-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intra-peritoneal-chemotherapy
#20
Eliza I-Lin Sin, Claramae Shulyn Chia, Grace Hwei Ching Tan, Khee Chee Soo, Melissa Ching-Ching Teo
BACKGROUND: Cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy (CRS-HIPEC) prolongs survival in patients with metastatic peritoneal disease. We look at the incidence of acute kidney injury (AKI) in patients who have received cisplatin during CRS-HIPEC in the treatment of peritoneal carcinomatosis from an ovarian primary, and identify possible peri-operative risk factors. METHODS: Between 2005 and 2013, we performed CRS-HIPEC on 47 patients with ovarian primaries and peritoneal metastasis...
March 5, 2017: International Journal of Hyperthermia
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