keyword
Keywords colorectal cancer, inflammator...

colorectal cancer, inflammatory bowel disease.

https://read.qxmd.com/read/38418112/occurrence-of-colorectal-cancer-after-a-negative-colonoscopy-in-patients-with-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#21
REVIEW
Giorgia Burrelli Scotti, Immacolata Iannone, Cristina DE Padua, Daniele Crocetti, Giulia Fiori, Paolo Sapienza, Enrico Fiori, Stefano Avenia, Antonietta Lamazza
BACKGROUND/AIM: Despite the application of colorectal cancer (CRC) surveillance guidelines, the detection of early neoplastic lesions might be difficult in patients with inflammatory bowel disease (IBD). To explore the risk of post-colonoscopy CRC (PCCRC) in patients with IBD we performed a systematic review and meta-analysis. PATIENTS AND METHODS: A systematic literature search was performed (PROSPERO; no. CRD42023453049). We included studies reporting the 3-year PCCRC (PCCRC-3y) prevalence, according to World Endoscopy Organization (WEO)-endorsed definition, in IBD and non-IBD patients...
2024: In Vivo
https://read.qxmd.com/read/38415550/tlr4-iga-and-epcam-expression-in-colorectal-cancer-and-their-possible-association-with-microbiota-as-a-pathogenic-factor-an-immunohistochemical-and-genetic-study
#22
JOURNAL ARTICLE
Fatma S Hafez, Marwa M Shakweer, Dina Sabry, Amany M Tawfik, Shaimaa Mohsen El-Beah, Nadia M Elsheshtawy, Lobna S Shash, Doaa E A Salama, Ahmed Gaballah
BACKGROUND: The pathogenesis of inflammatory bowel disease (IBD) and colorectal cancer (CRC) is thought to be related to immune response against gut microbiota. TLR4, IgA, and EpCAM have a role in intestinal local immune response and their altered expression related to both IBD and CRC. Lipopolysaccharide (LPS) is the main activator of TLR4. The objective of this study is to evaluate the possible role of intestinal microbiota in the pathogenesis of IBD and CRC through expression of TLR4, IgA and EpCAM...
February 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38415013/editorial-the-oral-gut-axis-from-ectopic-colonization-to-within-host-evolution-of-oral-bacteria
#23
EDITORIAL
Mohamed M H Abdelbary, Rehab Z Abdallah, Hee Sam Na
No abstract text is available yet for this article.
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38407208/risk-of-malignancy-in-a-high-incidence-population-based-cohort-of-faroese-patients-with-inflammatory-bowel-disease-from-1960-to-2020-a-faroese-ibd-cohort-study
#24
JOURNAL ARTICLE
Jóngerð Midjord, Kári Rubek Nielsen, Amanda Gratton Vang, Marin Strøm, Søren Lophaven, Turid Hammer, Johan Burisch
BACKGROUND: The association between inflammatory bowel disease (IBD) and malignancy remains disputed despite many observational studies. The Faroese population exhibits the highest occurrence of IBD in the world. This study aimed to investigate the cancer risk in Faroese IBD patients in a nationwide IBD cohort. METHODS: This study included all IBD patients diagnosed in the Faroe Islands between 1960 and 2020. Clinical demographics and cancer diagnoses were retrieved from patient files and the Faroese cancer registry...
February 26, 2024: Scandinavian Journal of Gastroenterology
https://read.qxmd.com/read/38405748/accessible-chromatin-maps-of-inflammatory-bowel-disease-intestine-nominate-cell-type-mediators-of-genetic-disease-risk
#25
Joseph A Wayman, Zi Yang, Elizabeth Angerman, Erin Bonkowski, Ingrid Jurickova, Xiaoting Chen, Anthony T Bejjani, Lois Parks, Sreeja Parameswaran, Alexander G Miethke, Kelli L VanDussen, Jasbir Dhaliwal, Matthew T Weirauch, Leah C Kottyan, Lee A Denson, Emily R Miraldi
Inflammatory Bowel Disease ( IBD ) is a chronic and often debilitating autoinflammatory condition, with an increasing incidence in children. Standard-of-care therapies lead to sustained transmural healing and clinical remission in fewer than one-third of patients. For children, TNFα inhibition remains the only FDA-approved biologic therapy, providing an even greater urgency to understanding mechanisms of response. Genome-wide association studies ( GWAS ) have identified 418 independent genetic risk loci contributing to IBD, yet the majority are noncoding and their mechanisms of action are difficult to decipher...
February 13, 2024: bioRxiv
https://read.qxmd.com/read/38398321/current-approaches-for-monitoring-of-patients-with-inflammatory-bowel-diseases-a-narrative-review
#26
REVIEW
Alessandro Vitello, Marcello Maida, Endrit Shahini, Fabio Salvatore Macaluso, Ambrogio Orlando, Mauro Grova, Daryl Ramai, Gaetano Serviddio, Antonio Facciorusso
BACKGROUND: Patients with inflammatory bowel diseases (IBD) require proactive monitoring both during the active phase to evaluate therapeutic response and during the remission phase to evaluate relapse or colorectal cancer surveillance. However, monitoring may vary between patients with ulcerative colitis (UC) and Crohn's disease (CD), with distinct tools and intervals. METHODS: This narrative review aims to focus on modern approaches to IBD monitoring, considering international guidelines and expert consensus...
February 9, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398179/therapeutic-potential-for-sphingolipids-in-inflammatory-bowel-disease-and-colorectal-cancer
#27
REVIEW
Keila S Espinoza, Ashley J Snider
Inflammatory bowel disease (IBD), characterized by chronic inflammation in the intestinal tract, increases the risk for the development of colorectal cancer (CRC). Sphingolipids, which have been implicated in IBD and CRC, are a class of bioactive lipids that regulate cell signaling, differentiation, apoptosis, inflammation, and survival. The balance between ceramide (Cer), the central sphingolipid involved in apoptosis and differentiation, and sphingosine-1-phosphate (S1P), a potent signaling molecule involved in proliferation and inflammation, is vital for the maintenance of normal cellular function...
February 15, 2024: Cancers
https://read.qxmd.com/read/38393664/way-262611-ameliorates-the-inflammatory-bowel-disease-by-activating-wnt-%C3%AE-catenin-pathway
#28
JOURNAL ARTICLE
Baiyinzi Du, Shudan Luo, Xujun Zhu, Maqing Hu, Xianzhang Feng, Qianjun Yu, Bin Bai, Jian Xu, Jun Wang
Inflammatory bowel disease (IBD) is a non-specific and relapsing intestinal inflammation. The injury and repair of intestinal epithelial together determine the occurrence and development of IBD. Wnt/β-catenin pathway is considered as the key role in the proliferation and differentiation of intestinal stem cells which is negative regulated by Dickkiop (DKKs). WAY-262611 is a novel inhibitor of DKK-1, and has demonstrated therapeutic effect on some disease including osteoporosis. Thus, we investigated the effect of WAY-262611 on IBD...
February 23, 2024: In Vitro Cellular & Developmental Biology. Animal
https://read.qxmd.com/read/38388570/ultra-processed-foods-and-food-additives-in-gut-health-and-disease
#29
REVIEW
Kevin Whelan, Aaron S Bancil, James O Lindsay, Benoit Chassaing
Ultra-processed foods (UPFs) and food additives have become ubiquitous components of the modern human diet. There is increasing evidence of an association between diets rich in UPFs and gut disease, including inflammatory bowel disease, colorectal cancer and irritable bowel syndrome. Food additives are added to many UPFs and have themselves been shown to affect gut health. For example, evidence shows that some emulsifiers, sweeteners, colours, and microparticles and nanoparticles have effects on a range of outcomes, including the gut microbiome, intestinal permeability and intestinal inflammation...
February 22, 2024: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/38383742/clinical-factors-associated-with-severity-in-patients-with-inflammatory-bowel-disease-in-brazil-based-on-2-year-national-registry-data-from-gediib
#30
JOURNAL ARTICLE
Renata de Sá Brito Fróes, Adriana Ribas Andrade, Mikaell Alexandre Gouvea Faria, Heitor Siffert Pereira de Souza, Rogério Serafim Parra, Cyrla Zaltman, Carlos Henrique Marques Dos Santos, Mauro Bafutto, Abel Botelho Quaresma, Genoile Oliveira Santana, Rafael Luís Luporini, Sérgio Figueiredo de Lima Junior, Sender Jankiel Miszputen, Mardem Machado de Souza, Giedre Soares Prates Herrerias, Roberto Luiz Kaiser Junior, Catiane Rios do Nascimento, Omar Féres, Jaqueline Ribeiro de Barros, Ligia Yukie Sassaki, Rogerio Saad-Hossne
The Brazilian Organization for Crohn's Disease and Colitis (GEDIIB) established a national registry of inflammatory bowel disease (IBD). The aim of the study was to identify clinical factors associated with disease severity in IBD patients in Brazil. A population-based risk model aimed at stratifying the severity of IBD based on previous hospitalization, use of biologics, and need for surgery for ulcerative colitis (UC) and Crohn's Disease (CD) and on previous complications for CD. A total of 1179 patients (34...
February 21, 2024: Scientific Reports
https://read.qxmd.com/read/38379560/editorial-insights-in-gastroenterology-2022
#31
EDITORIAL
Angel Lanas, Gonzalo Hijos-Mallada
No abstract text is available yet for this article.
2024: Frontiers in Medicine
https://read.qxmd.com/read/38374529/is-extended-venous-thromboprophylaxis-required-in-patients-undergoing-ileal-pouch-procedure-for-ulcerative-colitis
#32
JOURNAL ARTICLE
Javier Gomez, Evangelia Theodosopoulos, Helen MacRae, Mantaj S Brar, Anthony de Buck van Overstraeten, Brenda O'Connor, Harden Huang, Erin Kennedy
AIM: Venous thromboembolic events (VTEs) are relatively common adverse surgical complications. Extended VTE prophylaxis for 4 weeks is recommended after colorectal cancer surgery, but its use in inflammatory bowel disease surgery lacks high-quality evidence. This retrospective study aimed to assess and characterize VTEs within the first 30 days after ileal pouch-anal anastomosis (IPAA) procedures and subtotal colectomies (STCs) for ulcerative colitis (UC). METHODS: All patients who underwent IPAA for UC between 1 January 2017 and 31 December 2021 were included...
February 19, 2024: Colorectal Disease
https://read.qxmd.com/read/38363654/fnicm-a-new-methodology-to-identify-core-metabolites-based-on-significantly-perturbed-metabolic-subnetworks
#33
JOURNAL ARTICLE
Qi Li, Ying-Hao Yin, Zi-Wei Liu, Li-Fang Liu, Gui-Zhong Xin
Metabolomics has emerged as a powerful tool in biomedical research to understand the pathophysiological processes and metabolic biomarkers of diseases. Nevertheless, it is a significant challenge in metabolomics to identify the reliable core metabolites that are closely associated with the occurrence or progression of diseases. Here, we proposed a new research framework by integrating detection-based metabolomics with computational network biology for function-guided and network-based identification of core metabolites, namely, FNICM...
February 16, 2024: Analytical Chemistry
https://read.qxmd.com/read/38363072/ultra-processed-food-consumption-and-human-health-an-umbrella-review-of-systematic-reviews-with-meta-analyses
#34
REVIEW
Janett Barbaresko, Janine Bröder, Johanna Conrad, Edyta Szczerba, Alexander Lang, Sabrina Schlesinger
Recently, ultra-processed foods received a lot of attention, but also criticism. Our aim was to provide an overview of the existing evidence of ultra-processed food consumption on human health. We conducted a systematic search in four databases until January 5th, 2024. Systematic reviews with meta-analyses on ultra-processed food consumption as defined by the NOVA classification system were included. The certainty of evidence was evaluated by the GRADE approach. We identified 16 publications. Moderate certainty of evidence was found for all-cause mortality (Summary Risk Ratio per 50 g: 1...
February 16, 2024: Critical Reviews in Food Science and Nutrition
https://read.qxmd.com/read/38355645/increased-cpg-methylation-at-the-cdh1-locus-in-inflamed-ileal-mucosa-of-patients-with-crohn-disease
#35
JOURNAL ARTICLE
Charles de Ponthaud, Solafah Abdalla, Marie-Pierre Belot, Xiaojian Shao, Christophe Penna, Antoine Brouquet, Pierre Bougnères
BACKGROUND: E-cadherin, a major actor of cell adhesion in the intestinal barrier, is encoded by the CDH1 gene associated with susceptibility to Crohn Disease (CD) and colorectal cancer. Since epigenetic mechanisms are suspected to contribute to the multifactorial pathogenesis of CD, we studied CpG methylation at the CDH1 locus. The methylation of the CpG island (CGI) and of the 1st enhancer, two critical regulatory positions, was quantified in surgical specimens of inflamed ileal mucosa and in peripheral blood mononuclear cells (PBMC) of 21 CD patients...
February 14, 2024: Clinical Epigenetics
https://read.qxmd.com/read/38354883/pesticide-use-and-inflammatory-bowel-disease-in-licensed-pesticide-applicators-and-spouses-in-the-agricultural-health-study
#36
JOURNAL ARTICLE
Dazhe Chen, Christine G Parks, Jonathan N Hofmann, Laura E Beane Freeman, Dale P Sandler
BACKGROUND: Pesticide exposure has been linked to some autoimmune diseases and colorectal cancer, possibly via alteration of gut microbiota or other mechanisms. While pesticides have been linked to gut dysbiosis and inflammation in animal models, few epidemiologic studies have examined pesticides in relation to inflammatory bowel disease (IBD). OBJECTIVES: We evaluated use of pesticides and incident IBD in 68,480 eligible pesticide applicators and spouses enrolled in the Agricultural Health Study...
February 12, 2024: Environmental Research
https://read.qxmd.com/read/38354512/allulose-mitigates-chronic-enteritis-by-reducing-mitochondria-dysfunction-via-regulating-cathepsin-b-production
#37
JOURNAL ARTICLE
Fang Shi, Yong-Sheng Gao, Shu-Mei Han, Cheng-Suo Huang, Qing-Sheng Hou, Xiao-Wen Wen, Ben-Shi Wang, Zhen-Yu Zhu, Lei Zou
Metabolic changes have been linked to the development of inflammatory bowel disease (IBD), which includes colitis. Allulose, an endogenous bioactive monosaccharide, is vital to the synthesis of numerous compounds and metabolic processes within living organisms. Nevertheless, the precise biochemical mechanism by which allulose inhibits colitis remains unknown. Allulose is an essential and intrinsic protector of the intestinal mucosal barrier, as it maintains the integrity of tight junctions in the intestines, according to the current research...
February 13, 2024: International Immunopharmacology
https://read.qxmd.com/read/38352618/the-fanconi-anemia-pathway-repairs-colibactin-induced-dna-interstrand-cross-links
#38
Maria Altshuller, Xu He, Elliot J MacKrell, Kevin M Wernke, Joel W H Wong, Selene Sellés-Baiget, Ting-Yu Wang, Tsui-Fen Chou, Julien P Duxin, Emily P Balskus, Seth B Herzon, Daniel R Semlow
Colibactin is a secondary metabolite produced by bacteria present in the human gut and is implicated in the progression of colorectal cancer and inflammatory bowel disease. This genotoxin alkylates deoxyadenosines on opposite strands of host cell DNA to produce DNA interstrand cross-links (ICLs) that block DNA replication. While cells have evolved multiple mechanisms to resolve ("unhook") ICLs encountered by the replication machinery, little is known about which of these pathways promote resistance to colibactin-induced ICLs...
January 31, 2024: bioRxiv
https://read.qxmd.com/read/38341347/epithelial-metabolism-as-a-rheostat-for-intestinal-inflammation-and-malignancy
#39
REVIEW
Julian Schwärzler, Lisa Mayr, Felix Grabherr, Herbert Tilg, Timon E Adolph
The gut epithelium protects the host from a potentially hostile environment while allowing nutrient uptake that is vital for the organism. To maintain this delicate task, the gut epithelium has evolved multilayered cellular functions ranging from mucus production to hormone release and orchestration of mucosal immunity. Here, we review the execution of intestinal epithelial metabolism in health and illustrate how perturbation of epithelial metabolism affects experimental gut inflammation and tumorigenesis. We also discuss the impact of environmental factors and host-microbe interactions on epithelial metabolism in the context of inflammatory bowel disease and colorectal cancer...
February 9, 2024: Trends in Cell Biology
https://read.qxmd.com/read/38313367/causal-linkage-between-type-2-diabetes-mellitus-and-inflammatory-bowel-disease-an-integrated-mendelian-randomization-study-and-bioinformatics-analysis
#40
JOURNAL ARTICLE
Xiang Xiao, Xuanyu Wu, Lu Yi, Fengming You, Xueke Li, Chong Xiao
BACKGROUND: Observational studies have indicated associations between type 2 diabetes mellitus (T2DM) and both colorectal cancer (CRC) and inflammatory bowel disease (IBD). However, the underlying causality and biological mechanisms between these associations remains unclear. METHODS: We conducted a bidirectional Mendelian randomization (MR) analysis employing summary statistics from genome-wide association studies involving European individuals. The inverse variance weighting (IVW) method was the primary method used to assess causality...
2024: Frontiers in Endocrinology
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