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https://www.readbyqxmd.com/read/29133254/characteristics-and-progression-of-preclinical-inflammatory-bowel-disease
#1
Iago Rodríguez-Lago, Olga Merino, Irene Azagra, Ainara Maiz, Eva Zapata, Rebeca Higuera, Isabel Montalvo, María Fernández-Calderón, Paz Arreba, Juan Carrascosa, Ainara Iriarte, Isabel Portillo, Urko Aguirre, Manuel Barreiro-de Acosta, Miguel Muñoz-Navas, José Luis Cabriada
BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is a chronic disease usually diagnosed after the appearance of gastrointestinal symptoms. Little is known about IBD progression during its early and even preclinical phases. We aimed to determine the number of new incidental diagnoses of IBD in an older population, and evaluate disease progression from its early stages. METHODS: We performed a retrospective analysis of 31,005 colonoscopies performed during colorectal cancer screening of patients with positive results from fecal immunochemical tests, at 11 centers in the Basque Country (Spain) from 2009 through 2014...
November 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29129972/inflammation-and-colorectal-cancer
#2
Apple G Long, Emma T Lundsmith, Kathryn E Hamilton
Colorectal cancer (CRC) is the fourth most common cancer in both men and women in the United States, resulting in over 55,000 deaths annually. Environmental and genetic factors influence the development of CRC, and inflammation is a critical hallmark of cancer that may arise from a variety of factors. Purpose of review: While patients with inflammatory bowel disease (IBD) have a higher risk of developing CRC, sporadic CRCs may engender or be potentiated by inflammation as well. In this review, we focus on recent advances in basic and translational research utilizing murine models to understand the contribution of inflammatory signaling pathways to CRC...
August 2017: Current Colorectal Cancer Reports
https://www.readbyqxmd.com/read/29118756/th17-cell-and-epithelial-cell-crosstalk-during-inflammatory-bowel-disease-and-carcinogenesis
#3
REVIEW
Jan Kempski, Leonie Brockmann, Nicola Gagliani, Samuel Huber
The intestine is colonized by hundreds of different species of commensal bacteria, viruses, and fungi. Therefore, the intestinal immune system is constantly being challenged by foreign antigens. The immune system, the commensal microbiota, and the intestinal epithelial surface have to maintain a tight balance to guarantee defense against potential pathogens and to prevent chronic inflammatory conditions at the same time. Failure of these mechanisms can lead to a vicious cycle in which a perpetual tissue damage/repair process results in a pathological reorganization of the normal mucosal surface...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29114386/suppression-of-inflammation-and-tissue-damage-by-a-hookworm-recombinant-protein-in-experimental-colitis
#4
Ivana B Ferreira, Darren A Pickering, Sally Troy, John Croese, Alex Loukas, Severine Navarro
Gastrointestinal parasites, hookworms in particular, have evolved to cause minimal harm to their hosts when present in small numbers, allowing them to establish chronic infections for decades. They do so by creating an immunoregulatory environment that promotes their own survival, but paradoxically also benefits the host by protecting against the onset of many inflammatory diseases. To harness the therapeutic value of hookworms without using live parasites, we have examined the protective properties of the recombinant protein anti-inflammatory protein (AIP)-1, secreted in abundance by hookworms within the intestinal mucosa, in experimental colitis...
October 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29093240/current-issues-of-gastroenterology-in-indonesia
#5
Marcellus Simadibrata, Randy Adiwinata
Indonesia is one of the most populous developing countries in the world. Similar with other developing countries, Indonesia has been suffered from the high incidence of gastroenterology diseases that mainly due to infection. In the recent years, Indonesia had also increased number of non-infectious gastroenterology diseases cases such as inflammatory bowel disease, gastroesophageal reflux disease, and colorectal cancer. Nevertheless, the developments of diagnostic and therapeutic modality along with the cooperation between sectors have undergone rapid progress as an effort in improving digestive health in Indonesia...
July 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29081776/innate-lymphoid-cells-in-intestinal-inflammation
#6
REVIEW
Alessandra Geremia, Carolina V Arancibia-Cárcamo
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine that encompasses Crohn's disease (CD) and ulcerative colitis. The cause of IBD is unknown, but the evidence suggests that an aberrant immune response toward the commensal bacterial flora is responsible for disease in genetically susceptible individuals. Results from animal models of colitis and human studies indicate a role for innate lymphoid cells (ILC) in the pathogenesis of chronic intestinal inflammation in IBD. ILC are a population of lymphocytes that are enriched at mucosal sites, where they play a protective role against pathogens including extracellular bacteria, helminthes, and viruses...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29078383/quantitative-proteomics-identifies-steap4-as-a-critical-regulator-of-mitochondrial-dysfunction-linking-inflammation-and-colon-cancer
#7
Xiang Xue, Bryce X Bredell, Erik R Anderson, Angelical Martin, Christopher Mays, Hiroko Nagao-Kitamoto, Sha Huang, Balázs Győrffy, Joel K Greenson, Karin Hardiman, Jason R Spence, Nobuhiko Kamada, Yatrik M Shah
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder and is a major risk factor for colorectal cancer (CRC). Hypoxia is a feature of IBD and modulates cellular and mitochondrial metabolism. However, the role of hypoxic metabolism in IBD is unclear. Because mitochondrial dysfunction is an early hallmark of hypoxia and inflammation, an unbiased proteomics approach was used to assess the mitochondria in a mouse model of colitis. Through this analysis, we identified a ferrireductase: six-transmembrane epithelial antigen of prostate 4 (STEAP4) was highly induced in mouse models of colitis and in IBD patients...
October 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29072609/rome-criteria-and-a-diagnostic-approach-to-irritable-bowel-syndrome
#8
REVIEW
Brian E Lacy, Nihal K Patel
Functional gastrointestinal disorders (FGIDs) account for at least 40% of all referrals to gastroenterologists. Of the 33 recognized adult FGIDs, irritable bowel syndrome (IBS) is the most prevalent, with a worldwide prevalence estimated at 12%. IBS is an important health care concern as it greatly affects patients' quality of life and imposes a significant economic burden to the health care system. Cardinal symptoms of IBS include abdominal pain and altered bowel habits. The absence of abdominal pain makes the diagnosis of IBS untenable...
October 26, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29072418/colitis-associated-colorectal-cancer-in-patients-with-inflammatory-bowel-disease
#9
Se-Jin Baek, Seon-Hahn Kim
Colitis-associated colorectal cancer (CACRC) is a major concern in patients with long-standing inflammatory bowel disease (IBD). CACRC can develop under the influence of several risk factors including longer duration and disease extent and shows clinical and molecular features different from those of sporadic CRC. Several academic societies have recommended surveillance guidelines for CACRC that develops in IBD patients. Patients are stratified according to risk for CRC and differentiated by surveillance colonoscopy and management...
December 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29063998/diabetes-mellitus-and-the-colon
#10
REVIEW
Marc S Piper, Richard J Saad
Diabetes mellitus (DM) can affect the structure and function of the colon promoting commonly encountered lower gastrointestinal symptoms such as constipation, diarrhea, abdominal distention, bloating, and abdominal pain. Specific colonic disorders for which adults with DM are at greater risk include chronic constipation, enteropathic diarrhea, colorectal cancer (CRC), inflammatory bowel disease, microscopic colitis, and Clostridium difficile colitis. Smooth muscle structure and function, density of the interstitial cells of Cajal, and the health and function of the autonomic and enteric nerves of the colon are all potential affected by DM...
December 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29027585/the-features-of-adipose-derived-stem-cells-in-patients-with-inflammatory-bowel-diseases
#11
Tsunekazu Mizushima, Tadafumi Fukata, Hiroshi Takeyama, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Chu Matsuda, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori
PURPOSE: The treatment outcomes for inflammatory bowel disease (IBD) have been improving, but the development of better therapies is needed. Stem cell therapy is promising, but little is known about the differences in adipose-derived stem cells (ADSCs) between IBD patients and healthy individuals. METHODS: ADSCs were isolated from subcutaneous adipose tissue (SAT) in IBD (Crohn's disease, 3; ulcerative colitis, 2) and non-IBD (colorectal cancer, 5; breast cancer, 1) patients...
October 12, 2017: Surgery Today
https://www.readbyqxmd.com/read/29027468/serrated-polyposis-syndrome-associated-with-long-standing-inflammatory-bowel-disease
#12
Jesús Castro, Miriam Cuatrecasas, Francesc Balaguer, Elena Ricart, María Pellisé
Inflammatory bowel disease (IBD) patients are at an increased risk of developing colorectal cancer (CRC), which is thought to develop via the adenoma-carcinoma pathway. Since the discovery of the serrated carcinogenesis pathway and serrated polyposis syndrome (SPS), the incidence of carcinomas arising from serrated lesions in IBD patients has increased. We report three cases of long-standing IBD patients with associated serrated polyposis syndrome. At present, the pathophysiology of serrated lesions in IBD patients is not fully understood and there is a lack of strong evidence to confirm whether the manifestation of both conditions represents an increased risk of developing cancer...
November 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29018541/results-from-a-retrospective-analysis-of-colonoscopies-for-inflammatory-bowel-disease-and-colorectal-cancer-in-a-lebanese-tertiary-care-centre
#13
Toufic Saber, Khalil Bedran, Fatima Ghandour, Mansour El Khoury, Roula Bou Khalil, Said Farhat
BACKGROUND AND AIMS: Inflammatory bowel diseases (IBDs) and colorectal cancer have an increased impact on the Lebanese population's morbidity and mortality. This study evaluated the situation of IBD and colorectal cancer at a tertiary hospital centre in Lebanon. METHODS: 1007 patients underwent colonoscopy over a period of 12 months by qualified physicians. 91 patients were excluded from the study. Biopsy results were divided into normal versus abnormal colonic tissue...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29017293/endoscopic-therapeutic-approach-for-dysplasia-in-inflammatory-bowel-disease
#14
REVIEW
Sung Noh Hong
Long-standing intestinal inflammation in patients with inflammatory bowel disease (IBD) induces dysplastic change in the intestinal mucosa and increases the risk of subsequent colorectal cancer. The evolving endoscopic techniques and technologies, including dye spraying methods and high-definition images, have been replacing random biopsies and have been revealed as more practical and efficient for detection of dysplasia in IBD patients. In addition, they have potential usefulness in detailed characterization of lesions and in the assessment of endoscopic resectability...
September 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28987259/primary-sclerosing-cholangitis-what-the-gastroenterologist-and-hepatologist-needs-to-know
#15
REVIEW
Andrea A Gossard, Gregory J Gores
Primary sclerosing cholangitis (PSC) is a chronic, idiopathic biliary tract disease characterized by segmental strictures. The disease is progressive with no proven treatments and may eventually lead to cirrhosis and end-stage liver disease. Abrupt changes in liver biochemistries, pain, and/or cholangitis may suggest a dominant stricture amenable to endoscopic therapy or the development of cholangiocarcinoma. Patients with PSC are at increased risk of cholangiocarcinoma. There is a strong association with inflammatory bowel disease, and an associated increased risk of colorectal cancer...
November 2017: Clinics in Liver Disease
https://www.readbyqxmd.com/read/28983289/dietary-heme-induces-gut-dysbiosis-aggravates-colitis-and-potentiates-the-development-of-adenomas-in-mice
#16
Marco Constante, Gabriela Fragoso, Annie Calvé, Macha Samba-Mondonga, Manuela M Santos
Dietary heme can be used by colonic bacteria equipped with heme-uptake systems as a growth factor and thereby impact on the microbial community structure. The impact of heme on the gut microbiota composition may be particularly pertinent in chronic inflammation such as in inflammatory bowel disease (IBD), where a strong association with gut dysbiosis has been consistently reported. In this study we investigated the influence of dietary heme on the gut microbiota and inferred metagenomic composition, and on chemically induced colitis and colitis-associated adenoma development in mice...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28975893/the-esrp1-gpr137-axis-contributes-to-intestinal-pathogenesis
#17
Lukas Franz Mager, Viktor Hendrik Koelzer, Regula Stuber, Lester Thoo, Irene Keller, Ivonne Koeck, Maya Langenegger, Cedric Simillion, Simona P Pfister, Martin Faderl, Vera Genitsch, Irina Tcymbarevich, Pascal Juillerat, Xiaohong Li, Yu Xia, Eva Karamitopoulou, Ruth Lyck, Inti Zlobec, Siegfried Hapfelmeier, Rémy Bruggmann, Kathy D McCoy, Andrew J Macpherson, Christoph Müller, Bruce Beutler, Philippe Krebs
Aberrant alternative pre-mRNA splicing (AS) events have been associated with several disorders. However, it is unclear whether deregulated AS directly contributes to disease. Here, we reveal a critical role of the AS regulator epithelial splicing regulator protein 1 (ESRP1) for intestinal homeostasis and pathogenesis. In mice, reduced ESRP1 function leads to impaired intestinal barrier integrity, increased susceptibility to colitis and altered colorectal cancer (CRC) development. Mechanistically, these defects are produced in part by modified expression of ESRP1-specific Gpr137 isoforms differently activating the Wnt pathway...
October 4, 2017: ELife
https://www.readbyqxmd.com/read/28965228/chromoendoscopy-narrow-band-imaging-or-white-light-endoscopy-for-neoplasia-detection-in-inflammatory-bowel-diseases
#18
REVIEW
Ofir Har-Noy, Lior Katz, Tomer Avni, Robert Battat, Talat Bessissow, Diana E Yung, Tal Engel, Anastasios Koulaouzidis, Rami Eliakim, Shomron Ben-Horin, Uri Kopylov
BACKGROUND: Studies have confirmed an increased risk of colorectal cancer in patients with ulcerative colitis; hence, surveillance is recommended. Optional modalities include white light endoscopy (WLE) or dye-spray chromoendoscopy. However, narrow-band imaging (NBI) is still not considered comparable to chromoendoscopy. AIM: The aim of this study was to compare the diagnostic yield (DY) of WLE, chromoendoscopy, NBI for detection of neoplasia in patients with inflammatory bowel disease (IBD) by performing a meta-analysis of the existing literature...
November 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28961226/innovative-disease-model-zebrafish-as-an-in-vivo-platform-for-intestinal-disorder-and-tumors
#19
REVIEW
Jeng-Wei Lu, Yi-Jung Ho, Shih-Ci Ciou, Zhiyuan Gong
Colorectal cancer (CRC) is one of the world's most common cancers and is the second leading cause of cancer deaths, causing more than 50,000 estimated deaths each year. Several risk factors are highly associated with CRC, including being overweight, eating a diet high in red meat and over-processed meat, having a history of inflammatory bowel disease, and smoking. Previous zebrafish studies have demonstrated that multiple oncogenes and tumor suppressor genes can be regulated through genetic or epigenetic alterations...
September 29, 2017: Biomedicines
https://www.readbyqxmd.com/read/28960206/mir-148a-inhibits-colitis-and-colitis-associated-tumorigenesis-in-mice
#20
Yahui Zhu, Li Gu, Yajun Li, Xi Lin, Hongxing Shen, Kaisa Cui, Li Chen, Feng Zhou, Qiu Zhao, Jinxiang Zhang, Bo Zhong, Edward Prochownik, Youjun Li
miR-148a has been shown to regulate inflammation, immunity and the growth of certain tumors, but its roles in colitis and colorectal tumorigenesis remain largely undetermined. Here we found miR-148a-deficient mice to be more susceptible to colitis and colitis-associated tumorigenesis. Both were associated with increased nuclear factor κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) signaling. Bone marrow- and non-bone marrow-derived miR-148a contributed to colitis and colitis-associated tumorigenesis...
September 29, 2017: Cell Death and Differentiation
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