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alpha fetoprotein tumor marker

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https://www.readbyqxmd.com/read/28714367/parp-1-serves-as-a-novel-molecular-marker-for-hepatocellular-carcinoma-in-a-southern-chinese-zhuang-population
#1
Jiatong Li, Dongwei Dou, Ping Li, Wenqi Luo, Wenxin Lv, Chengdong Zhang, Xiaowei Song, Yuan Yang, Yuening Zhang, Yanzhen Xu, Feifan Xiao, Yan Wei, Jian Qin, Hongtao Li, Xiaoli Yang
PARP-1 (poly(ADP-ribose) polymerase-1) plays an important role in tumorigenesis. Since its effects on different populations are varied, this study investigated the impact of PARP-1 on primary hepatocellular carcinoma in a Southern Chinese Zhuang population. We assessed the global PARP-1 messenger RNA expression in patients with hepatocellular carcinoma using The Cancer Genome Atlas dataset. Increased PARP-1 expression, related to alpha-fetoprotein level, was observed. The area under the receiver operating characteristic curve value was 0...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28693887/novel-1-2-4-triazole-derivatives-as-antitumor-agents-against-hepatocellular-carcinoma
#2
Rasha R Radwan, Nashwa H Zaher, Marwa G El-Gazzar
Fifteen novel 1,2,3-triazole derivatives were prepared in series of synthetic steps starting from 4-amino-5-hydrazino-4H-1,2,4-triazole-3-thiol 1. The structures of the obtained compounds were verified through micoanalytical and spectral data. All the compounds were screened for their anticancer activity against liver human cancer cell lines (HEPG2) using Doxorubicin as standard. The most promising triazolothiadiazine derivative 12 was further tested for its degree of toxicity by estimating the median lethal dose (LD 50) and its antitumor activity through inhibiting the angiogenesis and progression of tumor against diethylnitrosamine (DENA)/CCl4 induced hepatocellular carcinoma (HCC) in rats...
July 8, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28689216/concentration-of-alpha-fetoprotein-and-%C3%AE-eta-human-chorionic-gonadotropin-tumor-markers-in-sulfur-mustard-exposed-veterans
#3
Mohammad Rafiee, Yunes Panahi, Mohammad Yousef Alikhani, Hassan Rafieemehr, Alireza Saadat, Mohammad Abbasi
No abstract text is available yet for this article.
July 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28672190/a-novel-signal-on-photoelectrochemical-immunosensor-for-detection-of-alpha-fetoprotein-by-in-situ-releasing-electron-donor
#4
Jiexia Chen, Guang-Chao Zhao
A signal-on photoelectrochemical (PEC) immunosensor was constructed for detecting tumor marker in this work. α-fetoprotein (AFP) was chosen as a model analyte to investigate the prepared procedure and the analytical performance of the exploited sensor. In order to construct the sensor, CdSe QDs were used as photoactive material, biotin conjugated AFP antibody (Bio-anti-AFP) as detecting probe, streptavidin (SA) as signal capturing unit, biotin functionalized apoferritin encapsulated ascorbic acid (Bio-APOAA) as amplification unit, which were assembled onto the electrodes...
June 24, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28663060/tg737-acts-as-a-key-driver-of-invasion-and-migration-in-liver-cancer-stem-cells-and-correlates-with-poor-prognosis-in-patients-with-hepatocellular-carcinoma
#5
Nan You, Ye Tan, Liang Zhou, Xiaobing Huang, Weiwei Wang, Liang Wang, Ke Wu, Na Mi, Jing Li, Lu Zheng
We previously demonstrated that the Tg737 gene plays a critical role in the carcinogenesis of hepatocellular carcinoma (HCC). However, few systematic investigations have focused on the biological function of Tg737 in the invasion and migration of liver cancer stem cells (LCSCs) and on its clinical significance. In this study, Tg737 overexpression was achieved via gene transfection in MHCC97-H side population (SP) cells, which are considered a model for LCSCs in scientific studies. Tg737 overexpression significantly inhibited the invasion and migration of SP cells in an extracellular signal-regulated kinase1/2 (ERK1/2)/matrix metalloproteinase-2 (MMP-2)-dependent manner...
June 27, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28660154/the-number-of-positive-tumor-marker-status-is-beneficial-for-the-selection-of-therapeutic-modalities-in-patients-with-hepatocellular-carcinoma
#6
REVIEW
Toru Beppu, Shigeki Nakagawa, Hidetoshi Nitta, Hirohisa Okabe, Takayoshi Kaida, Katsunori Imai, Hiromitsu Hayashi, Yuki Koga, Kunitaka Kuramoto, Daisuke Hashimoto, Yo-Ichi Yamashita, Akira Chikamoto, Takatoshi Ishiko, Hideo Baba
Hepatic resection (HR) and radiofrequency ablation (RFA) are popular local therapies for early-stage hepatocellular carcinoma (HCC). Alpha-fetoprotein, Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein, and des-c-carboxy prothrombin are well-known and useful tumor markers for HCC. The positive number status of these tumor markers has recently been demonstrated as beneficial for predicting outcome for HCC patients treated with local therapy. Although the normal ranges reported have differed by institution, the positivity of tumor markers is consistent and can easily be assessed...
June 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28621228/diagnostic-performance-of-tumor-markers-afp-and-pivka-ii-in-chinese-hepatocellular-carcinoma-patients
#7
Shujing Huang, Feifei Jiang, Ying Wang, Yanhua Yu, Siqian Ren, Xiaowei Wang, Peng Yin, Jinli Lou
Alpha-fetoprotein is an effective biomarker as an aid in hepatocellular carcinoma detection in many countries. However, alpha-fetoprotein has its limitations, especially in early hepatocellular carcinoma diagnosis. Protein induced by vitamin K absence or antagonist-II is another biomarker that is used for hepatocellular carcinoma detection. The aim of this study is to compare the diagnostic performance of alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II alone and in combination to explore improving biomarker performance as an aid in early hepatocellular carcinoma detection...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28618926/diagnostic-relevance-of-a-novel-multiplex-immunoassay-panel-in-breast-cancer
#8
Natalie Hermann, Katja Dressen, Lars Schroeder, Manuel Debald, Frank A Schildberg, Gisela Walgenbach-Bruenagel, Karina Hettwer, Steffen Uhlig, Walther Kuhn, Gunther Hartmann, Stefan Holdenrieder
Multiple factors contribute to the development and progression of breast cancer. Markers of tumor growth and invasion, cell death, immune activation, and angiogenesis can be assessed in parallel by a novel multiplex immunoassay panel. The diagnostic performance of a multiplex cancer biomarker magnetic bead panel comprising 24 tumor associated parameters was evaluated in sera of 154 women including 77 patients with breast cancer, 10 with precancerous lesions, 31 with benign breast diseases, and 36 healthy controls...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28611567/early-detection-of-hepatocellular-carcinoma-recurrence-using-the-highly-sensitive-fucosylated-fraction-of-alpha-fetoprotein
#9
Toru Setsu, Atsunori Tsuchiya, Takayuki Watanabe, Takuro Nagoya, Satoshi Ikarashi, Kazunao Hayashi, Junji Yokoyama, Satoshi Yamagiwa, Shuji Terai
Alpha-fetoprotein (AFP)-L3 was originally reported as a hepatocellular carcinoma (HCC)-specific tumor marker, and recent accumulation of evidence has revealed that AFP-L3 frequency predicts the biological malignancy potential of HCC. However, AFP-L3 elevation from undetectable levels after curative treatment could not be discussed due to the difficulties of calculating AFP-L3 concentrations when serum AFP levels were low. Here, as a novel method, we used highly sensitive AFP-L3 frequency to predict HCC recurrence after curative treatment...
January 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28583537/usefulness-of-pivka-ii-after-living-donor-liver-transplantation-for-hepatocellular-carcinoma
#10
M-S Park, K-W Lee, H Kim, Y R Choi, G Hong, N-J Yi, K-S Suh
OBJECTIVE: Prothrombin induced by the absence of vitamin K or antagonist-II (PIVKA-II) is a useful tumor marker for hepatocellular carcinoma (HCC). However, the usefulness of post-transplantation surveillance with PIVKA-II is not clear. We evaluated the clinical value of PIVKA-II in monitoring HCC recurrence after living-donor liver transplantation (LDLT). METHODS: One hundred twenty patients who had undergone LDLT for HCC from February 1999 to December 2010 and whose serum alpha-fetoprotein (AFP) and PIVKA-II had been measured sequentially before and after LDLT were included in this study...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28582340/a-report-of-ovarian-sertoli-leydig-cell-tumors-with-heterologous-intestinal-type-glands-and-alpha-fetoprotein-elevation-and-review-of-the-literature
#11
Maysa Al-Hussaini, Yazan Al-Othman, Eman Hijazi, W Glenn McCluggage
Ovarian Sertoli-Leydig cell tumors (SLCTs) are uncommon neoplasms that are occasionally associated with an elevated level of serum alpha fetoprotein (AFP), a marker of germ cell neoplasms, particularly yolk sac tumor (YST). We report 7 cases of ovarian SLCT (3 moderately differentiated, 2 poorly differentiated, 2 retiform) with heterologous intestinal-type glands, 6 of which were associated with elevated serum AFP. The intestinal-type mucinous glands were immunoreactive for SALL4 (4 cases), AFP (4 cases), glypican 3 (1 case), CDX2 (6 cases), and villin (7 cases), markers that are commonly expressed in YSTs, although the latter 2 markers would be expected to be positive in intestinal-type glands...
June 2, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28479767/reimbursements-and-frequency-of-tests-in-privately-insured-testicular-cancer-patients-in-the-united-states-implications-to-national-guidelines
#12
Mohamed H Kamel, Austin Barber, Rodney Davis, Omer A Raheem, Nabil Bissada, Alaa Eldin A Abdelmaksoud, Ehab Eltahawy
OBJECTIVES: The objective of this study was to assess the frequency of utilization and reimbursement of the common diagnostic tests and treatment modalities used in testicular cancer care. METHODS: LifeLink™ (IMS Health, Danbury, CT, USA) Claims Database was used. We identified 877 subjects with a primary diagnosis of testicular cancer (ICD 186.9) between 2007 and 2012. Median reimbursement and frequency of the diagnostic/treatment modalities used were recorded...
April 2017: Urology Annals
https://www.readbyqxmd.com/read/28471125/the-association-between-clinical-parameters-and-uterine-fibroid-size-in-patients-who-underwent-abdominal-myomectomy
#13
Mehmet Çınar, Rıfat Taner Aksoy, Ali İrfan Güzel, Aytekin Tokmak, Okan Yenicesu, Esma Sarıkaya, Özlem Evliyaoğlu
OBJECTIVES: To evaluate if there is an association between neutrophil lymphocyte ratio and tumor markers in patients with uterine fibroids. METHODS: A total of three hundred and fifty seven patients who operated for myomectomy were enrolled this retrospective case control study. Risk factors evaluated were; age, uterine fibroid type, body mass index (BMI), gravidity, parity, preoperative and postoperative hemoglobin difference, neutrophil/lymphocyte ratio (NLR), alpha fetoprotein (AFP), cancer antigen 125 (CA 125), cancer antigen 19-9 (CA 19-9), cancer antigen 15-3 (CA 15-3), carsino embryonic antigen (CEA) levels...
July 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28454733/capillary-electrochromatography-immunoassay-for-alpha-fetoprotein-based-on-poly-guanidinium-ionic-liquid-monolithic-material
#14
Cuicui Liu, Qiliang Deng, Guozhen Fang, Meng Dang, Shuo Wang
Alpha-fetoprotein (AFP) is widely used as a tumor marker for the serum diagnosis of primary hepatoma. Sensitive detection of AFP level plays an important role in the early diagnosis of disease and highly reliable prediction. In this study, a novel non-competitive immunoassay (IA) based on poly(guanidinium ionic liquid) monolithic material was developed for detecting ultra trace levels of AFP in capillary electrochromatography (CEC) mode. The AFP was mixed with an excess amount of fluorescently labeled antibody...
April 25, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28443252/open-label-phase-ii-clinical-trial-in-75-patients-with-advanced-hepatocellular-carcinoma-receiving-daily-dose-of-tableted-liver-cancer-vaccine-hepcortespenlisimut-l
#15
Marina G Tarakanovskaya, Jigjidsuren Chinburen, Purev Batchuluun, Chogsom Munkhzaya, Genden Purevsuren, Dorjiin Dandii, Tsogkhuu Hulan, Dandii Oyungerel, Galyna A Kutsyna, Alan A Reid, Vika Borisova, Allen I Bain, Vichai Jirathitikal, Aldar S Bourinbaiar
BACKGROUND: An increasing number of studies is now devoted to immunotherapy of cancer. We evaluated the clinical benefit of hepcortespenlisimut-L (Hepko-V5 [formerly known as V5])-an oral therapeutic vaccine designated by the United States Food and Drug Administration (FDA) as an orphan drug for treatment of hepatocellular carcinoma (HCC). V5 was initially developed by us in 2002 to treat hepatitis B or C viral infections and liver cirrhosis. METHODS: The outcome of open-label Phase II trial of daily dose of V5 pill was analyzed retrospectively...
2017: Journal of Hepatocellular Carcinoma
https://www.readbyqxmd.com/read/28407756/alpha-fetoprotein-elevation-in-nut-midline-carcinoma-a-case-report
#16
Lorenzo D'Ambrosio, Erica Palesandro, Marina Moretti, Giuseppe Pelosi, Alessandra Fabbri, Fabrizio Carnevale Schianca, Massimo Aglietta, Giovanni Grignani
BACKGROUND: Nuclear protein in testis (NUT) midline carcinoma is a rarely diagnosed and potentially under-recognized type of squamous carcinoma that is considered one of the most aggressive human solid tumors. Alpha-fetoprotein elevation has been associated with chronic liver diseases and a limited number of cancers. In particular, in presence of a mediastinal mass in a young man, alpha-fetoprotein elevation is considered nearly pathognomonic of a non-seminoma germ-cell tumor. CASE PRESENTATION: A 22-year old man without any comorbidity was diagnosed with a large mediastinal mass with skeletal and lymph node metastases...
April 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28306215/primary-mediastinal-and-retroperitoneal-malignant-germ-cell-tumors-in-children-and-adolescents-results-of-the-tgm95-trial-a-study-of-the-french-society-of-pediatric-oncology-soci%C3%A3-t%C3%A3-fran%C3%A3-aise-des-cancers-de-l-enfant
#17
Hélène Sudour-Bonnange, Cécile Faure-Conter, Hélène Martelli, Frederic Hameury, Brice Fresneau, Daniel Orbach, Cécile Vérité
PURPOSE: To examine the clinical presentation, treatment and results in children and adolescents with primary mediastinal (PM) and retroperitoneal (RP) germ cell tumors (GCTs). METHODS: The TGM95 trial for malignant GCTs was conducted in France between 1995 and 2005 to evaluate a strategy adapted to prognostic factors with cisplatin-based chemotherapy and surgical management. We reviewed patients with TGCTs at PM and RP sites. RESULTS: Among 239 patients, there were 16 patients with PM and 5 with RP tumors, which represent 9% of all patients, highlighting the rarity of these extragonadal locations...
March 17, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28302204/-a-preliminary-study-of-retinoblastoma-related-serum-tumor-markers
#18
Zhi-Ping Liu, Ke-Ying Zhou, Li-Li Chen, Zhi-Hui Xiao, Yan-Zhao Chen
OBJECTIVE: To screen out retinoblastoma (RB)-related serum tumor markers by measuring the levels of serum alpha fetoprotein (AFP), carcino-embryonic antigen (CEA), neuron-specific enolase (NSE), carbohydrate antigen 125 (CA125), carbohydrate antigen 153 (CA153), carbohydrate antigen 199 (CA199), and carbohydrate antigen 724 (CA724) in children with RB. METHODS: The levels of seven serum tumor markers (AFP, CEA, NSE, CA125, CA153, CA199, and CA724) were determined in 20 children with RB and 20 healthy children (control) using a chemiluminescent immunoassay...
March 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28302001/liver-transplantation-for-hepatocellular-carcinoma-beyond-the-milan-criteria
#19
Fulya Gunsar
Hepatocellular carcinoma is the most common primary liver malignancy. Liver transplantation has been a successful therapy for selected patients with hepatocellular carcinoma. Since 1996, Milan criteria have been universally recognized as the guidelines for selecting patients with hepatocellular carcinoma for orthotopic liver transplantation. However, the simple use of tumor size and number has been insufficient to indicate the biologic features of hepatocellular carcinoma and to predict the risk of tumor recurrence...
March 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28299619/double-and-triple-positive-tumor-markers-predict-early-recurrence-and-poor-survival-in-patients-with-hepatocellular-carcinoma-within-the-milan-criteria-and-child-pugh-class-a
#20
Tomoki Ryu, Yuko Takami, Yoshiyuki Wada, Masaki Tateishi, Hajime Matsushima, Kazuhiro Mikagi, Hideki Saitsu
The prognostic implications of the expression patterns of three tumor markers, alpha-fetoprotein (AFP), the Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3) and des-γ-carboxy prothrombin (DCP), have been evaluated in patients with hepatocellular carcinoma (HCC). From January 1994 to December 2014, 1182 consecutive patients underwent hepatic resection and surgical microwave ablation for HCC at our institution. This study analyzed 475 patients within the Milan criteria and Child-Pugh class A. Cumulative overall survival (OS) and disease-free survival (DFS) rates were analyzed relative to the number of positive tumor markers...
March 15, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
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