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alpha fetoprotein tumor marker

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https://www.readbyqxmd.com/read/29751042/next-generation-sequencing-analysis-for-gastric-adenocarcinoma-with-enteroblastic-differentiation-emphasis-on-the-relationship-with-hepatoid-adenocarcinoma
#1
Yoichi Akazawa, Tsuyoshi Saito, Takuo Hayashi, Yuka Yanai, Sho Tsuyama, Keisuke Akaike, Yoshiyuki Suehara, Fumiyuki Takahashi, Kazuya Takamochi, Hiroya Ueyama, Takashi Murakami, Sumio Watanabe, Akihito Nagahara, Takashi Yao
Histologically tubulo-papillary structures with glycogen-rich clear cytoplasm in gastric adenocarcinoma with enteroblastic differentiation (GAED) are well-known, but a solid growth pattern can also be observed as a minor component. In contrast, hepatoid adenocarcinoma (HAC) of the stomach shows many overlapping features, including solid pattern and alpha-fetoprotein expression. In this study, we employed next-generation sequencing (NGS) to establish a molecular/clinicopathological concept of GAED and clarify whether these two tumors should be grouped together in one category...
May 8, 2018: Human Pathology
https://www.readbyqxmd.com/read/29740214/role-of-beclin1-expression-in-patients-with-hepatocellular-carcinoma-a-meta-analysis
#2
Chaojie Liang, Wei Li, Hua Ge, Kaitong Zhang, Guangming Li, Jixiang Wu
Background and aim: Beclin1 has been reported as a vital marker for a number of malignant tumors. However, the role of Beclin1 in hepatocellular carcinoma (HCC) remains inconclusive. Thus, we conducted a meta-analysis to assess the correlation between Beclin1 and its clinicopathological and prognostic values in HCC. Methods: PubMed, Cochrane Library, Web of Science, EMBASE, Chinese CNKI, and Chinese WanFang databases were searched for published articles on Beclin1 expression in hepatocellular tissues...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29689031/platelet-distribution-width-in-hepatocellular-carcinoma
#3
Fenfen Guo, Xuan Zhu, Xue Qin
BACKGROUND Platelets and platelet activation are involved in the critical steps of tumor cell growth, metastasis, and angiogenesis. In this study, we analyzed the correlation between platelet distribution width (PDW) and hepatocellular carcinoma (HCC). MATERIAL AND METHODS HCC patients at the First Affiliated Hospital of Guangxi Medical University, China, from January 2017 to October 2017, were analyzed retrospectively. The control group comprised healthy persons at the hospital for medical check-ups during the same period...
April 24, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29594421/direct-determination-of-the-tumor-marker-afp-via-silver-nanoparticle-enhanced-sers-and-afp-modified-gold-nanoparticles-as-capturing-substrate
#4
Chenmeng Zhang, Yukun Gao, Nan Yang, Tingting You, Huaxiang Chen, Penggang Yin
The authors describe a rapid and direct SERS-based immunoassay for the determination of AFP, an important marker for diagnosis of hepatocellular carcinoma. Silver nanoparticles (AgNPs; 36 nm i.d.) serve as a support to immobilize antibody and as a SERS intensifier, and AFP-modified gold nanoparticles are employed as capturing substrate. Direct and quantitative detection of AFP is accomplished with a limit detection as low as 5 ng·mL-1 . Compared to assays based on the use of metal nanoparticles, the use of gold-silver nanoparticle heterodimers as an active SERS substrate can save costs because only a single antibody is required...
January 8, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29576865/hcc-with-low-and-normal-serum-alpha-fetoprotein-levels
#5
Brian I Carr, Hikmet Akkiz, Oguz Üsküdar, Kendal Yalçın, Vito Guerra, Sedef Kuran, Ümit Karaoğullarından, Engin Altıntaş, Ayşegül Özakyol, Salih Tokmak, Tuğsan Ballı, Mehmet Yücesoy, Halil İbrahim Bahçeci, Abdulalh Ülkü, Tolga Akçam, Kamil Yalçın Polat, Nazım Ekinci, Halis Şimşek, Necati Örmeci, Abdulalh Sonsuz, Mehmet Demir, Murat Kılıç, Ahmet Uygun, Ali Demir, Anıl Delik, Burcu Arslan, Figen Doran, Sezai Yilmaz, Yaman Tokat
A large database of 1773 HCC patients in Turkey was examined. 41.9% had alpha-fetoprotein (AFP) levels <20 IU/ml and an additional 16.123% had values between 20-100 IU/ml. This 58% of the cohort (<100 IU/ml AFP levels) was examined in detail. 66% of patients with small (<5 cm) HCCs had low AFP, compared to 49% of patients with larger (>5 cm) HCCs. The mean diameter (MTD) of larger MTD, low AFP tumors was 8.4cm. Therefore, factors other than AFP must contribute to HCC tumor growth. Larger tumors in low AFP patients had both higher platelet levels and increased PVT percent...
2018: Clinical Practice
https://www.readbyqxmd.com/read/29575509/patient-selection-by-tumor-markers-in-liver-transplantation-for-advanced-hepatocellular-carcinoma
#6
Hae Won Lee, Gi-Won Song, Sung-Gyu Lee, Jong Man Kim, Jae-Won Joh, Dai Hoon Han, Soon Il Kim, Seong Hoon Kim, Dong-Sik Kim, Jai Young Cho, Kyung-Suk Suh
BACKGROUND: Although far advanced hepatocellular carcinoma (HCC) is generally considered a contraindication for liver transplantation (LT), biologically favorable tumors among them could show acceptable results. However, it is still unclear which tumors can be treated with LT. METHODS: Data were collected on adult patients who underwent LT for HCC beyond the Milan criteria in eight Korean LT centers between Jan 2000 and Jun 2013. Far advanced HCC was defined as HCC with the largest tumor ≥ 10cm, 10 or more tumor nodules, or accompanying macro-vascular invasion...
March 25, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29545598/ubiquitin-specific-protease-11-serves-as-a-marker-of-poor-prognosis-and-promotes-metastasis-in-hepatocellular-carcinoma
#7
Sheng Zhang, Chengrong Xie, Honghe Li, Kang Zhang, Jie Li, Xiaomin Wang, Zhenyu Yin
Ubiquitin-specific protease 11 (USP11) is a deubiquitinating enzyme that exerts its biological functions by regulating multiple signaling pathways such as p53, NF-κB, TGF-β, and Hippo. A large body of evidence supports a link between UPS11 and tumorigenesis. However, the clinical significance and biological function of USP11 in hepatocellular carcinoma (HCC) remains unclear. Here, USP11 expression was assessed by immunohistochemistry in a pilot series of 71 HCC clinical samples, and the association between USP11 expression and clinicopathological features and overall survival time was analyzed...
March 15, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29505494/alpha-fetoprotein-slope-7-5-ng-ml-per-month-predicts-microvascular-invasion-and-tumor-recurrence-after-liver-transplantation-for-hepatocellular-carcinoma
#8
Jeanne-Marie Giard, Neil Mehta, Jennifer L Dodge, John P Roberts, Francis Y Yao
BACKGROUND: Rising alpha-fetoprotein (AFP) is a potential marker of worse prognosis after liver transplant (LT) for hepatocellular carcinoma (HCC), but prior studies relied on only 2 data points and were imprecise in assessing AFP slope. The aim of this study was to examine the association between AFP slope and post-LT HCC recurrence, with AFP slope estimated from multiple data points over time. METHODS: Our cohort included 336 patients undergoing LT with Model for End Stage Liver Disease exception for HCC within Milan criteria from 2003 to 2013...
May 2018: Transplantation
https://www.readbyqxmd.com/read/29484118/genetic-correction-improves-prediction-efficiency-of-serum-tumor-biomarkers-on-digestive-cancer-risk-in-the-elderly-chinese-cohort-study
#9
Ke Wang, Yansen Bai, Shi Chen, Jiao Huang, Jing Yuan, Weihong Chen, Ping Yao, Xiaoping Miao, Youjie Wang, Yuan Liang, Xiaomin Zhang, Meian He, Handong Yang, Qingyi Wei, Huan Guo, Sheng Wei
Although serum tumor biomarkers alpha-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) have been used in digestive cancer risk prediction, the prediction efficiency remains unsatisfactory. The aim of this study was to evaluate whether genetic correction could improve the efficiency of these biomarkers for prediction of digestive cancer risk. We conducted a prospective analysis in 9,808 healthy individuals based on a cohort study in the elderly Chinese population. The genotypes of reported single nucleotide polymorphisms (SNPs) associated with serum AFP, CA19-9 and CEA were used to estimate the genetic corrected levels of these markers...
January 26, 2018: Oncotarget
https://www.readbyqxmd.com/read/29452105/label-free-electrochemical-aptasensor-for-detection-of-alpha-fetoprotein-based-on-afp-aptamer-and-thionin-reduced-graphene-oxide-gold-nanoparticles
#10
Guiyin Li, Shanshan Li, Zhihong Wang, Yewei Xue, Chenyang Dong, Junxiang Zeng, Yong Huang, Jintao Liang, Zhide Zhou
Sensitive and accurate detection of tumor markers is critical to early diagnosis, point-of-care and portable medical supervision. Alpha fetoprotein (AFP) is an important clinical tumor marker for hepatocellular carcinoma (HCC), and the concentration of AFP in human serum is related to the stage of HCC. In this paper, a label-free electrochemical aptasensor for AFP detection was fabricated using AFP-aptamer as the recognition molecule and thionin/reduced graphene oxide/gold nanoparticles (TH/RGO/Au NPs) as the sensor platform...
April 15, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29425853/sandwich-type-electrochemical-immunoassay-based-on-co-3-o-4-mno-2-thionine-and-pseudo-elisa-method-toward-sensitive-detection-of-alpha-fetoprotein
#11
Yaoguang Wang, Guanhui Zhao, Huan Wang, Wei Cao, Bin Du, Qin Wei
In this study, a sensitive sandwich-type electrochemical immunosensor was fabricated for the detection of alpha fetoprotein (AFP) based on Co3 O4 @MnO2 -thionine (Co3 O4 @MnO2 -Th) and the screen printing technique. Meanwhile, the pseudo enzyme-linked immunosorbent assay (pseudo-ELISA) method was applied in fabricating the immunosensor. Screen-printed carbon electrode (SPCE) was applied for achieving the detection of AFP. Simultaneously, the amino functionalized Co3 O4 @MnO2 -Th was employed as secondary label and could greatly improve the electrochemical response signal, which was beneficial for detecting AFP...
May 30, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29424599/screening-of-biomarkers-for-liver-adenoma-in-low-dose-rate-%C3%AE-ray-irradiated-mice
#12
Takashi Sugihara, Satoshi Tanaka, Ignacia Braga-Tanaka, Hayato Murano, Masako Nakamura-Murano, Jun-Ichiro Komura
PURPOSE: Chronic low-dose-rate (20 mGy/day) γ-irradiation increases the incidence of hepatocellular adenomas (HCA) in female B6C3F1 mice. The purpose of this study is to identify potential serum biomarkers for these HCAs by a new approach. MATERIAL AND METHODS: Microarray analysis were performed to compare the gene expression profiles of HCAs from mice exposed to low-dose-rate γ-rays with those of normal livers from non-irradiated mice. From the differentially expressed genes, those for possibly secretory proteins were selected...
April 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29396555/ubiquitin-specific-protease-4-promotes-hepatocellular-carcinoma-progression-via-cyclophilin-a-stabilization-and-deubiquitination
#13
Tianyi Li, Bin Yan, Yang Ma, Junyong Weng, Shouwen Yang, Nan Zhao, Xiaoliang Wang, Xing Sun
Ubiquitin-specific protease 4 (USP4) is a member of the deubiquitinating enzyme family, which plays an important role in human tumor diseases. However, the mechanisms by which USP4 facilitates tumor development, especially in hepatocellular carcinoma (HCC), remain unclear. Clinically, we found that USP4 is overexpressed in human HCC tissues compared with adjacent non-tumoral tissues and is significantly correlated with malignant phenotype characteristics, including tumor size, tumor number, differentiation, serum alpha-fetoprotein level, and vascular invasion...
February 2, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29376136/clinical-and-molecular-sub-classification-of-hepatocellular-carcinoma-relative-to-alpha-fetoprotein-level-in-an-asia-pacific-island-cohort
#14
Scott T Nishioka, Miles M Sato, Linda L Wong, Maarit Tiirikainen, Sandi A Kwee
Aim: Increased serum alpha-fetoprotein (AFP) levels are associated with specific molecular sub-classes of hepatocellular carcinoma (HCC), supporting AFP as a predictive or therapeutic biomarker for precision treatment of this disease. Considering recent efforts to validate HCC molecular classification systems across different populations, we applied existing signature-based classification templates to Hawaii cohorts and examined whether associations between HCC molecular sub-class, AFP levels, and clinical features found elsewhere can also be found in Hawaii, a region with a unique demographic and risk factor profile for HCC...
2018: Hepatoma Research
https://www.readbyqxmd.com/read/29361814/angiomyolipoma-of-the-liver-without-a-fat-component-mimicking-a-hepatocellular-carcinoma
#15
Yong Moon Woo, Soo Hyung Ryu, Jeong Wha Min, Mi Ryeong Kim, Tae Young Park, Jeong Seop Moon, Yun Kyung Kang
Angiomyolipoma (AML) is a rare benign mesenchymal tumor in the liver, which is composed of blood vessels, smooth muscle, and adipose cells. The proportion of each component varies, making a diagnosis difficult. This paper reports a case of AML in the liver without adipose tissue, mimicking a hepatocellular carcinoma (HCC), which was diagnosed by a surgical tissue biopsy. A 65-year-old woman was admitted for an evaluation of a hepatic mass that had been detected by ultrasonography. The serologic markers of viral hepatitis B and C were negative...
January 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29348089/a-study-of-serological-markers-and-lipid-profile-in-non-alcoholic-liver-cirrhosis-patients
#16
Sadaf Khan, Siddiqua Jamal
Cirrhosis is the end result of chronic liver damage, associated with altered serum biomarkers and lipid profile. However, only few studies regarding serum biomarkers and plasma lipid profile in non-alcoholic liver cirrhosis subjects have been undertaken in Pakistan. This study aimed to evaluate the degree of alterations of tumor markers and lipid profile in liver cirrhosis patients and in normal healthy individuals. Levels of serological markers and plasma lipid pattern was measured in liver cirrhosis patients and in sex and age matched normal healthy individuals (n=46)...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29286241/multiplexed-detection-of-tumor-markers-with-multicolor-polymer-dot-based-immunochromatography-test-strip
#17
Chia-Chia Fang, Chia-Cheng Chou, Yong-Quan Yang, Tsai Wei-Kai, Yeng-Tseng Wang, Yang-Hsiang Chan
There have been ongoing efforts to develop more sensitive and fast quantitative screening of cancer markers by use of fluorometric immunochromatographic test strips (ICTS) since the remarkable advances in fluorescent nanomaterials. Semiconducting polymer dots (Pdots) have recently emerged as a new type of biocompatible fluorescent probe with extraordinary brightness which is suitable for biological and clinical use. Here, we developed Pdot-based ICTS for quantitative rapid screening of prostate-specific antigen (PSA), α-fetoprotein (AFP), and carcinoembryonic antigen (CEA) in 10 min...
February 6, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29238703/characterization-of-alpha-fetoprotein-effects-on-dendritic-cell-and-its-function-as-effector-immune-response-activator
#18
Jeremiah Suryatenggara, Heri Wibowo, Wahyuni Lukita Atmodjo, George Mathew
Tumor antigen alpha-fetoprotein (AFP) can promote immune tolerance toward tumor cells by inducing regulatory functions of the immune system. The purpose of this study was to characterize the effects of AFP on dendritic cells (DC) in their antitumor immune response stimulation and subsequent immune tolerance toward tumor cells. Monocytes were cultured in medium with GM-CSF and IL-4 and incubated for 6 days to generate immature DC (imDC). AFP was added into the treatment group at the beginning of the monocyte-derived DC culture...
2017: Journal of Hepatocellular Carcinoma
https://www.readbyqxmd.com/read/29192630/diagnostic-utility-of-alpha-fetoprotein-and-des-gamma-carboxyprothrombin-in-nigerians-with-hepatocellular-carcinoma
#19
Akpakip Ikpong Ette, D A Ndububa, O Adekanle, U Ekrikpo
BACKGROUND: Alpha-fetoprotein (AFP) and Des-gamma-carboxyprothrombin (DCP) have been extensively studied as biomarkers for the diagnosis of and prognostication in hepatocellular carcinoma (HCC). However there are only few reports on the clinical characteristics of hepatocellular carcinoma in relation to the combination of the two tumor markers in hepatitis B virus-related HCC. AIM: The aim of this study was to investigate the clinical characteristics of HBV-related HCC in relation to different sets of AFP and DCP values...
October 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29172446/a-compatible-sensitivity-enhancement-strategy-for-electrochemiluminescence-immunosensors-based-on-the-biomimetic-melanin-like-deposition
#20
Hongmin Ma, Yanhua Zhao, Yuanyuan Liu, Yong Zhang, Dan Wu, He Li, Qin Wei
In this work, a compatible strategy was demonstrated for the enhancement of detection sensitivity of sandwich-type electrochemiluminescence (ECL) immunosensors. The enhanced signal response was based on the combination of biomimetic melanin-like deposition with the effective ECL quenching ability of quinone-rich biopolymers. Gold nanoparticle-loaded horseradish peroxidase (HRP) was used as a catalytic label for the secondary antibodies. The intrinsic catalytic property of HRP toward hydrogen peroxide (H2 O2 ) generates reactive oxygen species, which highly promote the autopolymerization of catecholamines...
December 19, 2017: Analytical Chemistry
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