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alpha fetoprotein tumor marker

Sheng Zhang, Chengrong Xie, Honghe Li, Kang Zhang, Jie Li, Xiaomin Wang, Zhenyu Yin
Ubiquitin-specific protease 11 (USP11) is a deubiquitinating enzyme that exerts its biological functions by regulating multiple signaling pathways such as p53, NF-κB, TGF-β, and Hippo. A large body of evidence supports a link between UPS11 and tumorigenesis. However, the clinical significance and biological function of USP11 in hepatocellular carcinoma (HCC) remains unclear. Here, USP11 expression was assessed by immunohistochemistry in a pilot series of 71 HCC clinical samples, and the association between USP11 expression and clinicopathological features and overall survival time was analyzed...
March 15, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
Jeanne-Marie Giard, Neil Mehta, Jennifer L Dodge, John P Roberts, Francis Y Yao
BACKGROUND: Rising alpha-fetoprotein (AFP) is a potential marker of worse prognosis after liver transplant (LT) for hepatocellular carcinoma (HCC), but prior studies relied on only two data points and were imprecise in assessing AFP slope. The aim of this study was to examine the association between AFP slope and post-LT HCC recurrence, with AFP slope estimated from multiple data points over time. METHODS: Our cohort included 336 patients undergoing LT with MELD exception for HCC within Milan criteria from 2003-2013...
January 17, 2018: Transplantation
Ke Wang, Yansen Bai, Shi Chen, Jiao Huang, Jing Yuan, Weihong Chen, Ping Yao, Xiaoping Miao, Youjie Wang, Yuan Liang, Xiaomin Zhang, Meian He, Handong Yang, Qingyi Wei, Huan Guo, Sheng Wei
Although serum tumor biomarkers alpha-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) have been used in digestive cancer risk prediction, the prediction efficiency remains unsatisfactory. The aim of this study was to evaluate whether genetic correction could improve the efficiency of these biomarkers for prediction of digestive cancer risk. We conducted a prospective analysis in 9,808 healthy individuals based on a cohort study in the elderly Chinese population. The genotypes of reported single nucleotide polymorphisms (SNPs) associated with serum AFP, CA19-9 and CEA were used to estimate the genetic corrected levels of these markers...
January 26, 2018: Oncotarget
Guiyin Li, Shanshan Li, Zhihong Wang, Yewei Xue, Chenyang Dong, Junxiang Zeng, Yong Huang, Jintao Liang, Zhide Zhou
Sensitive and accurate detection of tumor markers is critical to early diagnosis, point-of-care and portable medical supervision. Alpha fetoprotein (AFP) is an important clinical tumor marker for hepatocellular carcinoma (HCC), and the concentration of AFP in human serum is related to the stage of HCC. In this paper, a label-free electrochemical aptasensor for AFP detection was fabricated using AFP-aptamer as the recognition molecule and thionin/reduced graphene oxide/gold nanoparticles (TH/RGO/Au NPs) as the sensor platform...
February 13, 2018: Analytical Biochemistry
Yaoguang Wang, Guanhui Zhao, Huan Wang, Wei Cao, Bin Du, Qin Wei
In this study, a sensitive sandwich-type electrochemical immunosensor was fabricated for the detection of alpha fetoprotein (AFP) based on Co3O4@MnO2-thionine (Co3O4@MnO2-Th) and the screen printing technique. Meanwhile, the pseudo enzyme-linked immunosorbent assay (pseudo-ELISA) method was applied in fabricating the immunosensor. Screen-printed carbon electrode (SPCE) was applied for achieving the detection of AFP. Simultaneously, the amino functionalized Co3O4@MnO2-Th was employed as secondary label and could greatly improve the electrochemical response signal, which was beneficial for detecting AFP...
February 3, 2018: Biosensors & Bioelectronics
Takashi Sugihara, Satoshi Tanaka, Ignacia Braga-Tanaka, Hayato Murano, Masako Nakamura-Murano, Jun-Ichiro Komura
PURPOSE: Chronic low-dose-rate (20 mGy/d) gamma-irradiation increases the incidence of hepatocellular adenomas (HCA) in female B6C3F1 mice. The purpose of this study is to identify potential serum biomarkers for these HCAs by a new approach. MATERIAL AND METHODS: Microarray analysis were performed to compare the gene expression profiles of HCAs from mice exposed to low-dose-rate gamma rays with those of normal livers from non-irradiated mice. From the differentially expressed genes, those for possibly secretory proteins were selected...
February 9, 2018: International Journal of Radiation Biology
Tianyi Li, Bin Yan, Yang Ma, Junyong Weng, Shouwen Yang, Nan Zhao, Xiaoliang Wang, Xing Sun
Ubiquitin-specific protease 4 (USP4) is a member of the deubiquitinating enzyme family, which plays an important role in human tumor diseases. However, the mechanisms by which USP4 facilitates tumor development, especially in hepatocellular carcinoma (HCC), remain unclear. Clinically, we found that USP4 is overexpressed in human HCC tissues compared with adjacent non-tumoral tissues and is significantly correlated with malignant phenotype characteristics, including tumor size, tumor number, differentiation, serum alpha-fetoprotein level, and vascular invasion...
February 2, 2018: Cell Death & Disease
Scott T Nishioka, Miles M Sato, Linda L Wong, Maarit Tiirikainen, Sandi A Kwee
Aim: Increased serum alpha-fetoprotein (AFP) levels are associated with specific molecular sub-classes of hepatocellular carcinoma (HCC), supporting AFP as a predictive or therapeutic biomarker for precision treatment of this disease. Considering recent efforts to validate HCC molecular classification systems across different populations, we applied existing signature-based classification templates to Hawaii cohorts and examined whether associations between HCC molecular sub-class, AFP levels, and clinical features found elsewhere can also be found in Hawaii, a region with a unique demographic and risk factor profile for HCC...
2018: Hepatoma Research
Yong Moon Woo, Soo Hyung Ryu, Jeong Wha Min, Mi Ryeong Kim, Tae Young Park, Jeong Seop Moon, Yun Kyung Kang
Angiomyolipoma (AML) is a rare benign mesenchymal tumor in the liver, which is composed of blood vessels, smooth muscle, and adipose cells. The proportion of each component varies, making a diagnosis difficult. This paper reports a case of AML in the liver without adipose tissue, mimicking a hepatocellular carcinoma (HCC), which was diagnosed by a surgical tissue biopsy. A 65-year-old woman was admitted for an evaluation of a hepatic mass that had been detected by ultrasonography. The serologic markers of viral hepatitis B and C were negative...
January 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
Sadaf Khan, Siddiqua Jamal
Cirrhosis is the end result of chronic liver damage, associated with altered serum biomarkers and lipid profile. However, only few studies regarding serum biomarkers and plasma lipid profile in non-alcoholic liver cirrhosis subjects have been undertaken in Pakistan. This study aimed to evaluate the degree of alterations of tumor markers and lipid profile in liver cirrhosis patients and in normal healthy individuals. Levels of serological markers and plasma lipid pattern was measured in liver cirrhosis patients and in sex and age matched normal healthy individuals (n=46)...
January 2018: Pakistan Journal of Pharmaceutical Sciences
Chia-Chia Fang, Chia-Cheng Chou, Yong-Quan Yang, Wei-Kai Tsai, Yeng-Tseng Wang, Yang-Hsiang Chan
There have been ongoing efforts to develop more sensitive and fast quantitative screening of cancer markers by use of fluorometric immunochromatographic test strip (ICTS) since the remarkable advances in fluorescent nanomaterials. Semiconducting polymer dots (Pdots) have recently emerged as a new type of biocompatible fluorescent probes with extraordinary brightness which is suitable for biological and clinical use. Here we developed Pdot-based ICTS for quantitative rapid screening of prostate-specific antigen (PSA), alpha-fetoprotein (AFP), and carcinoembryonic antigen (CEA) in 10 min...
December 29, 2017: Analytical Chemistry
Jeremiah Suryatenggara, Heri Wibowo, Wahyuni Lukita Atmodjo, George Mathew
Tumor antigen alpha-fetoprotein (AFP) can promote immune tolerance toward tumor cells by inducing regulatory functions of the immune system. The purpose of this study was to characterize the effects of AFP on dendritic cells (DC) in their antitumor immune response stimulation and subsequent immune tolerance toward tumor cells. Monocytes were cultured in medium with GM-CSF and IL-4 and incubated for 6 days to generate immature DC (imDC). AFP was added into the treatment group at the beginning of the monocyte-derived DC culture...
2017: Journal of Hepatocellular Carcinoma
Akpakip Ikpong Ette, D A Ndububa, O Adekanle, U Ekrikpo
BACKGROUND: Alpha-fetoprotein (AFP) and Des-gamma-carboxyprothrombin (DCP) have been extensively studied as biomarkers for the diagnosis of and prognostication in hepatocellular carcinoma (HCC). However there are only few reports on the clinical characteristics of hepatocellular carcinoma in relation to the combination of the two tumor markers in hepatitis B virus-related HCC. AIM: The aim of this study was to investigate the clinical characteristics of HBV-related HCC in relation to different sets of AFP and DCP values...
October 2017: Nigerian Journal of Clinical Practice
Hongmin Ma, Yanhua Zhao, Yuanyuan Liu, Yong Zhang, Dan Wu, He Li, Qin Wei
In this work, a compatible strategy was demonstrated for the enhancement of detection sensitivity of sandwich-type electrochemiluminescence (ECL) immunosensors. The enhanced signal response was based on the combination of biomimetic melanin-like deposition with the effective ECL quenching ability of quinone-rich biopolymers. Gold nanoparticle-loaded horseradish peroxidase (HRP) was used as a catalytic label for the secondary antibodies. The intrinsic catalytic property of HRP toward hydrogen peroxide (H2 O2 ) generates reactive oxygen species, which highly promote the autopolymerization of catecholamines...
December 19, 2017: Analytical Chemistry
Fan Feng, Yangzi Tian, Guanghui Xu, Zhen Liu, Shushang Liu, Gaozan Zheng, Man Guo, Xiao Lian, Daiming Fan, Hongwei Zhang
BACKGROUND: The diagnostic and prognostic significance of carcinoembryonic antigen (CEA), carbohydrate associated antigen 19-9 (CA19-9), alpha-fetoprotein (AFP) and cancer antigen 125 (CA125) in early gastric cancer have not been investigated yet. Thus, the present study aimed to explore the diagnostic and prognostic significance of the four tumor markers for early gastric cancer. METHODS: From September 2008 to March 2015, 587 early gastric cancer patients were given radical gastrectomy in our center...
November 9, 2017: BMC Cancer
Rohan C Siriwardana, Chandika A H Liyanage, Bhagya Gunetilleke, Madunil A Niriella, Janaka de Silva, Anuradha S Dassanayake, Subani P Jayatunge
BACKGROUND: Data on diffuse-type hepatocellular carcinoma (HCC) are rare. HCC in Sri Lanka is rising, and the majority is related to nonalcoholic fatty liver disease. This study was planned to compare nodular- and diffuse-type HCC in this cohort. METHODS: CT scans of 227 patients with HCC negative for infective hepatitis were analyzed and grouped as nodular and diffuse from July 2011 to July 2014. Diffuse-type cancer was defined as a tumor without convex/distinct margin, diffusely infiltrating the hepatic parenchyma...
September 2017: Gastrointestinal Tumors
Xiao-Wen Huang, Yang Huang, Li-da Chen, Zhu Wang, Zheng Yang, Jin-Ya Liu, Xiao-Yan Xie, Ming-De Lu, Shun-Li Shen, Wei Wang
PURPOSE: To evaluate the diagnostic performance of the combination of tumor markers [alpha-fetoprotein (AFP) and carbohydrate antigen 19-9 (CA19-9)] and imaging features in differentiating combined hepatocellular-cholangiocarcinoma (CHC) from hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). METHODS: Forty consecutive patients with pathologically proven CHC were retrospectively evaluated with contrast-enhanced ultrasound (CEUS). Additionally, 40 HCC and 40 CC patients who were randomly selected from the same period served as a control group...
October 20, 2017: Journal of Medical Ultrasonics
Ramona C Dolscheid-Pommerich, Mignon Keyver-Paik, Thomas Hecking, Walther Kuhn, Gunther Hartmann, Birgit Stoffel-Wagner, Stefan Holdenrieder
Evidence is sparse regarding the clinical performance of luminescent oxygen channeling immunoassays-based tumor marker assays in gynecological cancer. Analyzing serum samples of 336 patients with Dimension™Vista1500, we investigated the diagnostic power of carbohydrate antigen 15-3, carbohydrate antigen 125, carcinoembryonic antigen, carbohydrate antigen 19-9, and alpha-fetoprotein in patients suffering from different types of gynecological cancer and precancerous gynecological diseases and compared findings to appropriate control groups...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Quirino Lai, Samuele Iesari, Fabio Melandro, Gianluca Mennini, Massimo Rossi, Jan Lerut
The role of alpha-fetoprotein (AFP) in the specific setting of the diagnosis and prognosis of patients with hepatocellular cancer (HCC) waiting for liver transplantation (LT) is still controversial. Recently, a marked interest for this marker has been reported, mainly related to its ability to predict the outcome of HCC patients after LT. The growing number of papers in PubMed indicates that AFP has begun a "second life" in the particular context of LT. Looking at the most recent International Guidelines on HCC, it looks obvious that time is ripe to reevaluate the value of AFP in relation to its prognostic ability to identify HCC patients at high-risk for drop-out before and recurrence after LT...
2017: Translational Gastroenterology and Hepatology
Jaana Nevalainen, Teemu Korpimaki, Heikki Kouru, Mikko Sairanen, Markku Ryynanen
OBJECTIVE: To develop a predictive risk model for early-onset pre-eclampsia (EO-PE) using maternal characteristics, combined screening markers, previously reported biomarkers for PE and mean arterial pressure (MAP). METHODS: This retrospective study was conducted at Oulu University hospital between 2006 and 2010. Maternal serum from first trimester combined screening was further analyzed for alpha fetoprotein (AFP), placental growth factor (PlGF), soluble tumor necrosis factor receptor-1 (sTNFR1), retinol binding protein-4 (RBP4), a disintegrin and metalloprotease-12 (ADAM12), soluble P-selectin (sP-selectin), follistatin like-3 (FSTL3), adiponectin, angiopoietin-2 (Ang-2) and sex hormone binding globulin (SHBG)...
October 2017: Metabolism: Clinical and Experimental
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