keyword
MENU ▼
Read by QxMD icon Read
search

whisker

keyword
https://www.readbyqxmd.com/read/28072605/oxytocin-alleviates-orofacial-mechanical-hypersensitivity-associated-with-infraorbital-nerve-injury-via-vasopressin-1a-receptors-of-the-rat-trigeminal-ganglia
#1
Asako Kubo, Masamichi Shinoda, Ayano Katagiri, Mamoru Takeda, Tatsuro Suzuki, Junichi Asaka, David C Yeomans, Koichi Iwata
Oxytocin (OXT) is a neuropeptide hormone synthesized and secreted by hypothalamic neurons, and has been reported to play a significant role in pain modulation. However, the mechanisms underlying OXT's antinociceptive effect on neuropathic pain are not fully understood. In the present study, we examined the peripheral effect of OXT on mechanical hypersensitivity induced by partial ligation of the infraorbital nerve (PNL) in rats. Mechanical hypersensitivity in the whisker pad skin following PNL was attenuated by the direct administration of OXT into the trigeminal ganglion (TG)...
January 7, 2017: Pain
https://www.readbyqxmd.com/read/28069927/impact-of-altered-cholinergic-tones-on-the-neurovascular-coupling-response-to-whisker-stimulation
#2
Clotilde Lecrux, Claire H Sandoe, Sujaya Neupane, Pascal Kropf, Xavier Toussay, Xin-Kang Tong, María Lacalle-Aurioles, Amir Shmuel, Edith Hamel
Brain imaging techniques that use vascular signals to map changes in neuronal activity rely on the coupling between electrophysiology and hemodynamics, a phenomenon referred to "neurovascular coupling" (NVC). It is unknown whether this relationship remains reliable under altered brain states associated to acetylcholine (ACh) levels, such as attention and arousal, and in pathological conditions like Alzheimer's disease. We therefore assessed the effects of varying ACh tone on whisker evoked-NVC responses in rat barrel cortex, measured by cerebral blood flow (CBF) and neurophysiological recordings (local field potentials, LFPs)...
January 9, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28047841/tu-h-207a-04-how-patient-positioning-in-ct-affects-more-than-the-aec-image-noise-uniformity-and-ct-number-changes-as-a-function-of-positioning
#3
T Szczykutowicz, A Duplissis, D Miller
PURPOSE: Studies dealing with patient positioning in CT have mainly dealt with dose and image noise changes. For diagnosis, only dose decreases can negatively affect the diagnostic utility of the exam via an increase in image noise. However, a little studied consequence of poor positioning is CT number and noise uniformity changes. METHODS: An anthropomorphic phantom was imaged in 2 cm vertical steps between the highest and lowest couch positions. CT number and noise were measured using regions of interest (ROI) in the upper-thorax, mid-thorax, and abdomen...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042008/does-time-heal-all-wounds-experimental-diffuse-traumatic-brain-injury-results-in-persisting-histopathology-in-the-thalamus
#4
Theresa Currier Thomas, Sarah B Ogle, Benjamin M Rumney, Hazel G May, P David Adelson, Jonathan Lifshitz
BACKGROUND: Thalamic dysfunction has been implicated in overall chronic neurological dysfunction after traumatic brain injury (TBI), however little is known about the underlying histopathology. In experimental diffuse TBI (dTBI), we hypothesize that persisting histopathological changes in the ventral posteromedial (VPM) nucleus of the thalamus is indicative of progressive circuit reorganization. Since circuit reorganization in the VPM impacts the whisker sensory system, the histopathology could explain the development of hypersensitivity to whisker stimulation by 28days post-injury; similar to light and sound hypersensitivity in human TBI survivors...
December 29, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/28039950/ageing-causes-prominent-neurovascular-dysfunction-associated-with-loss-of-astrocytic-contacts-and-gliosis
#5
Jessica Duncombe, Ross J Lennen, Maurits A Jansen, Ian Marshall, Joanna M Wardlaw, Karen Horsburgh
AIMS: Normal neurovascular coupling, mediated by the fine interplay and communication of cells within the neurovascular unit, is critical for maintaining normal brain activity and cognitive function. This study investigated whether, with advancing age there is disruption of neurovascular coupling and specific cellular components of the neurovascular unit, and whether the effects of increasing amyloid (a key feature of Alzheimer's disease) would exacerbate these changes. METHODS: Wild-type mice, in which amyloid deposition is absent, were compared to transgenic APP littermates (TgSwDI) which develop age-dependent increases in amyloid...
December 31, 2016: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28039402/high-and-low-conductance-nmda-receptors-are-present-in-layer-4-spiny-stellate-and-layer-2-3-pyramidal-neurons-of-mouse-barrel-cortex
#6
Christian Scheppach
N-Methyl-D-aspartate (NMDA) receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance. Recently, synaptic plasticity has been studied in the mouse barrel cortex, the primary sensory cortex for input from the animal's whiskers. Pharmacological data imply the presence of low-conductance NMDA receptors in spiny stellate neurons of cortical layer 4, but of high-conductance NMDA receptors in pyramidal neurons of layer 2/3...
December 2016: Physiological Reports
https://www.readbyqxmd.com/read/28024745/assessment-of-ambient-background-concentrations-of-elements-in-soil-using-combined-survey-and-open-source-data
#7
Hannah G Mikkonen, Bradley O Clarke, Raghava Dasika, Christian J Wallis, Suzie M Reichman
Understanding ambient background concentrations in soil, at a local scale, is an essential part of environmental risk assessment. Where high resolution geochemical soil surveys have not been undertaken, soil data from alternative sources, such as environmental site assessment reports, can be used to support an understanding of ambient background conditions. Concentrations of metals/metalloids (As, Mn, Ni, Pb and Zn) were extracted from open-source environmental site assessment reports, for soils derived from the Newer Volcanics basalt, of Melbourne, Victoria, Australia...
December 23, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28018178/associations-of-unilateral-whisker-and-olfactory-signals-induce-synapse-formation-and-memory-cell-recruitment-in-bilateral-barrel-cortices-cellular-mechanism-for-unilateral-training-toward-bilateral-memory
#8
Zilong Gao, Lei Chen, Ruicheng Fan, Wei Lu, Dangui Wang, Shan Cui, Li Huang, Shidi Zhao, Sudong Guan, Yan Zhu, Jin-Hui Wang
Somatosensory signals and operative skills learned by unilateral limbs can be retrieved bilaterally. In terms of cellular mechanism underlying this unilateral learning toward bilateral memory, we hypothesized that associative memory cells in bilateral cortices and synapse innervations between them were produced. In the examination of this hypothesis, we have observed that paired unilateral whisker and odor stimulations led to odorant-induced whisker motions in bilateral sides, which were attenuated by inhibiting the activity of barrel cortices...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28012155/influence-of-chitosan-chitin-nanofiber-composites-on-cytoskeleton-structure-and-the-proliferation-of-rat-bone-marrow-stromal-cells
#9
Victoria V Kiroshka, Valentina A Petrova, Daniil D Chernyakov, Yulia O Bozhkova, Katerina V Kiroshka, Yulia G Baklagina, Dmitry P Romanov, Roman V Kremnev, Yury A Skorik
Chitosan scaffolds have gained much attention in various tissue engineering applications, but the effect of their microstructure on cell-material spatial interactions remains unclear. Our objective was to evaluate the effect of chitosan-based matrices doping with chitin nano-whiskers (CNW) on adhesion, spreading, cytoskeleton structure, and proliferation of rat bone marrow stromal cells (BMSCs). The behavior of BMSCs during culture on chitosan-CNW films was determined by the molecular mass, hydrophobicity, porosity, crosslinking degree, protonation degree and molecular structure of the composite chitosan-CNW films...
January 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28009277/movement-initiation-signals-in-mouse-whisker-motor-cortex
#10
Varun Sreenivasan, Vahid Esmaeili, Taro Kiritani, Katia Galan, Sylvain Crochet, Carl C H Petersen
Frontal cortex plays a central role in the control of voluntary movements, which are typically guided by sensory input. Here, we investigate the function of mouse whisker primary motor cortex (wM1), a frontal region defined by dense innervation from whisker primary somatosensory cortex (wS1). Optogenetic stimulation of wM1 evokes rhythmic whisker protraction (whisking), whereas optogenetic inactivation of wM1 suppresses initiation of whisking. Whole-cell membrane potential recordings and silicon probe recordings of action potentials reveal layer-specific neuronal activity in wM1 at movement initiation, and encoding of fast and slow parameters of movements during whisking...
December 21, 2016: Neuron
https://www.readbyqxmd.com/read/28008068/active-cortical-dendrites-modulate-perception
#11
Naoya Takahashi, Thomas G Oertner, Peter Hegemann, Matthew E Larkum
There is as yet no consensus concerning the neural basis of perception and how it operates at a mechanistic level. We found that Ca(2+) activity in the apical dendrites of a subset of layer 5 (L5) pyramidal neurons in primary somatosensory cortex (S1) in mice is correlated with the threshold for perceptual detection of whisker deflections. Manipulating the activity of apical dendrites shifted the perceptual threshold, demonstrating that an active dendritic mechanism is causally linked to perceptual detection...
December 23, 2016: Science
https://www.readbyqxmd.com/read/28003414/high-velocity-stimulation-evokes-dense-population-response-in-layer-2-3-vibrissal-cortex
#12
Yadollah Ranjbar-Slamloo, Ehsan Arabzadeh
Supra-granular layers of sensory cortex are known to exhibit sparse firing. In rodent vibrissal cortex, a small fraction of neurons in layer 2 and 3 (L2/3) respond to whisker stimulation. Here, we combined whole-cell recording and two-photon imaging in anesthetized mice and quantified the synaptic response and spiking profile of L2/3 neurons. Previous literature has shown that neurons across layers of vibrissal cortex are tuned to the velocity of whisker movement. We therefore used a broad range of stimuli that included the standard range of velocities (0-1...
December 21, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28003158/central-sensitization-related-changes-of-effective-and-functional-connectivity-in-the-rat-inflammatory-trigeminal-pain-model
#13
Tamás Spisák, Zsófia Pozsgay, Csaba Aranyi, Szabolcs Dávid, Pál Kocsis, Gabriella Nyitrai, Dávid Gajári, Miklós Emri, András Czurkó, Zsigmond Tamás Kincses
Central sensitization is a key mechanism in the pathology of several neuropathic pain disorders. We aimed to investigate the underlying brain connectivity changes in a rat model of chronic pain. Non-noxious whisker stimulation was used to evoke blood-oxygen-level-dependent (BOLD) responses in a block-design functional Magnetic Resonance Imaging (fMRI) experiment on 9.4T. Measurements were repeated two days and one week after injecting complete Freund's adjuvant into the rats' whisker pad. We found that acute pain reduced activation in the barrel cortex, most probably due to a plateau effect...
December 18, 2016: Neuroscience
https://www.readbyqxmd.com/read/28002632/hypoxia-and-hyperoxia-differentially-control-proliferation-of-rat-neural-crest-stem-cells-via-distinct-regulatory-pathways-of-the-hif1%C3%AE-cxcr4-and-tp53-tpm1-proteins
#14
Chien-Cheng Chen, Ching-Wu Hsia, Cheng-Wen Ho, Chang-Min Liang, Chieh-Min Chen, Kun-Lun Huang, Bor-Hwang Kang, Yi-Hui Chen
BACKGROUND: Neural crest stem cells (NCSCs) are a population of adult multipotent stem cells. We are interested in studying whether oxygen tensions affect the capability of NCSCs to self-renew and repair damaged tissues. NCSCs extracted from the hair follicle bulge region of the rat whisker pad were cultured in vitro under different oxygen tensions. RESULTS: We found significantly increased and decreased rates of cell proliferation in rat NCSCs (rNCSCs) cultured respectively at 0...
December 21, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27990452/review-of-mesoscopic-optical-tomography-for-depth-resolved-imaging-of-hemodynamic-changes-and-neural-activities
#15
REVIEW
Qinggong Tang, Jonathan Lin, Vassiliy Tsytsarev, Reha S Erzurumlu, Yi Liu, Yu Chen
Understanding the functional wiring of neural circuits and their patterns of activation following sensory stimulations is a fundamental task in the field of neuroscience. Furthermore, charting the activity patterns is undoubtedly important to elucidate how neural networks operate in the living brain. However, optical imaging must overcome the effects of light scattering in the tissue, which limit the light penetration depth and affect both the imaging quantitation and sensitivity. Laminar optical tomography (LOT) is a three-dimensional (3-D) in-vivo optical imaging technique that can be used for functional imaging...
January 2017: Neurophotonics
https://www.readbyqxmd.com/read/27965859/the-ibra-implant-breast-reconstruction-evaluation-study-protocol-for-a-prospective-multi-centre-cohort-study-to-inform-the-feasibility-design-and-conduct-of-a-pragmatic-randomised-clinical-trial-comparing-new-techniques-of-implant-based-breast-reconstruction
#16
Shelley Potter, Elizabeth J Conroy, Paula R Williamson, Steven Thrush, Lisa J Whisker, Joanna M Skillman, Nicola L P Barnes, Ramsey I Cutress, Elizabeth M Teasdale, Nicola Mills, Senthurun Mylvaganam, Olivier A Branford, Katherina McEvoy, Abhilash Jain, Matthew D Gardiner, Jane M Blazeby, Christopher Holcombe
BACKGROUND: Implant-based breast reconstruction (IBBR) is the most commonly performed reconstructive procedure in the UK. The introduction of techniques to augment the subpectoral pocket has revolutionised the procedure, but there is a lack of high-quality outcome data to describe the safety or effectiveness of these techniques. Randomised controlled trials (RCTs) are the best way of comparing treatments, but surgical RCTs are challenging. The iBRA (implant breast reconstruction evaluation) study aims to determine the feasibility, design and conduct of a pragmatic RCT to examine the effectiveness of approaches to IBBR...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27965535/sensory-input-dependent-changes-in-glutamatergic-neurotransmission-related-genes-and-proteins-in-the-adult-rat-trigeminal-ganglion
#17
Julia Fernández-Montoya, Izaskun Buendia, Yasmina B Martin, Javier Egea, Pilar Negredo, Carlos Avendaño
Experience-dependent plasticity induces lasting changes in the structure of synapses, dendrites, and axons at both molecular and anatomical levels. Whilst relatively well studied in the cortex, little is known about the molecular changes underlying experience-dependent plasticity at peripheral levels of the sensory pathways. Given the importance of glutamatergic neurotransmission in the somatosensory system and its involvement in plasticity, in the present study, we investigated gene and protein expression of glutamate receptor subunits and associated molecules in the trigeminal ganglion (TG) of young adult rats...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27959854/-by-a-whisker-charles-darwin-and-medicine
#18
EDITORIAL
Héctor O Alonso
No abstract text is available yet for this article.
2016: Medicina
https://www.readbyqxmd.com/read/27927797/-express-electrophysiological-property-and-chemical-sensitivity-of-primary-afferent-neurons-that-innervate-rat-whisker-hair-follicles
#19
Ryo Ikeda, Jianguo Gu
No abstract text is available yet for this article.
2016: Molecular Pain
https://www.readbyqxmd.com/read/27923742/neuronal-adaptation-in-the-somatosensory-system-of-rodents
#20
REVIEW
I Lampl, Y Katz
The sensory systems in animals constantly monitor the environment and process salient and relevant features while subtracting background activity. This process requires continuous recalibration of neuronal gain based on recent history. Adaptation has been postulated to be the key mechanism by which neurons rapidly tune their response curves to represent the entire dynamic range of external inputs. Rodents heavily rely on their vibrissa system while gathering information about their surroundings using whisking...
December 5, 2016: Neuroscience
keyword
keyword
107668
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"