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https://www.readbyqxmd.com/read/29226428/predictive-value-of-18-f-fdg-pet-ct-scanning-in-combination-with-clinical-parameters-in-patients-with-newly-diagnosed-multiple-myeloma
#1
Honglei Tu, Yong He, Tianhe Huang, Songguk Choe, Xiaoli Lan, Xiaoyi Duan, Haseeb Sattar, Chongjiao Li, Fuling Zhou
OBJECTIVE: To evaluate the association of 18 F-2'-deoxy 2'-fluorodeoxyglucose (18 F-FDG) PET/CT with clinical parameters in predicting patients with newly diagnosed multiple myeloma (MM). METHODS: 120 MM patients undergoing 18 F-FDG PET/CT scanning were analyzed in a retrospective cohort study. RESULTS: Based on multivariate analysis, β2M, LDH, number of focal lesions (FLs) and SUVmax were significantly correlated with OS. These 4 variables were used to construct a new staging system (NSS) based on the number of risk factors...
December 11, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29207597/inhibition-of-miro1-disturbs-mitophagy-and-pancreatic-%C3%AE-cell-function-interfering-insulin-release-via-irs-akt-foxo1-in-diabetes
#2
Lingling Chen, Chunyan Liu, Jianfeng Gao, Zhiwen Xie, Lawrence W C Chan, Damien J Keating, Yibin Yang, Jiazhong Sun, Fuling Zhou, Yongchang Wei, Xiuli Men, Sijun Yang
Mitochondrial function is essential to meet metabolic demand of pancreatic beta cells respond to high nutrient stress. Mitophagy is an essential component to normal pancreatic β-cell function and has been associated with β-cell failure in Type 2 diabetes (T2D). Our previous studies have indicated that mitochondrial Rho (Miro) GTPase-mediated mitochondrial dysfunction under high nutrient stress leads to NOD-like receptor 3 (NLRP3)-dependent proinflammatory responses and subsequent insulin resistance. However, the in vivo mechanism by which Miro1 underlies mitophagy has not been identified...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29201170/a-network-pharmacology-approach-to-investigate-the-pharmacological-effects-of-guizhi-fuling-wan-on-uterine-fibroids
#3
Liuting Zeng, Kailin Yang, Huiping Liu, Guomin Zhang
To investigate the pharmacological mechanism of Guizhi Fuling Wan (GFW) in the treatment of uterine fibroids, a network pharmacology approach was used. Information on GFW compounds was collected from traditional Chinese medicine (TCM) databases, and input into PharmMapper to identify the compound targets. Genes associated with uterine fibroids genes were then obtained from the GeneCards and Online Mendelian Inheritance in Man databases. The interaction data of the targets and other human proteins was also collected from the STRING and IntAct databases...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29194948/chagosendines-a-c-new-metal-complexes-of-imidazole-alkaloids-from-the-calcareous-sponge-leucetta-chagosensis
#4
Bang An, Fuling Yin, Nicole J de Voogd, Xiaoguang Chen, Wei Cheng, Wenhan Lin
Chemical examination of the bright yellow sponge Leucetta chagosensis resulted in the isolation of three new imidazole-based alkaloid complexes namely chagosendines A-C (1-3), together with known analogues pyronaamidine, naamidine J, and naamine C. Their structures were determined on the basis of extensive spectroscopic (IR, MS, NMR and single-crystal X-ray diffraction) analysis in association with the chemical conversion. The isolated alkaloids together with three synthesized new homodimer complexes were evaluated for the antitumor activities...
November 30, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29192448/-simultaneous-determination-of-six-triterpenoid-acids-from-guizhi-fuling-capsules-by-uplc-ms-ms
#5
Ying Ma, Jia-Chun Li, Wen-Zhe Huang, Zhen-Zhong Wang, Wei Xiao, Ya-Ling Song, Yong-Wen Zhang
To establish a UPLC-MS/MS method for simultaneous determination of six triterpenoid constituents (pachymic acid, dehydropachymic acid, dehydrotumulosic acid, polyporenic acid C, dehydroeburicoic acid and dehydrotra metenolic acid) in Guizhi Fuling capsules (GFC). Chromatographic analysis was conducted on Agilent Porosheell 120 SB-C₁₈ column (4.6 mm×150 mm, 2.7 μm), with 0.1% formic acid aqueous solution-methanol as the mobile phase for gradient elution at a flow rate of 0.4 mL•min-1. The column temperature was 30 ℃ and the sample size was 5 μL...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29110400/spaghetti-a-homolog-of-human-rpap3-rna-polymerase-ii-associated-protein-3-determines-the-fate-of-germline-stem-cells-in-drosophila-ovary
#6
Dongsheng Chen, Xiaoqian Tao, Lijuan Zhou, Fuling Sun, Mingzhong Sun, Xin Fang
The Drosophila ovary provides an attractive model for studying the extrinsic or intrinsic factors that regulate the fate of germline stem cells (GSCs). Using this model, we identified a new role for Drosophila spaghetti (spag), encoding a homolog of human RNA polymerase II-associated protein 3 (RPAP3), in regulating the fate of ovarian GSCs. Results from spag knockdown and genetic mosaic studies suggest that spag functions as an intrinsic factor for GSCs maintenance. Loss of Spag by, either spag RNAi or null mutation failed to trigger apoptosis in ovarian GSCs...
November 7, 2017: Cell Biology International
https://www.readbyqxmd.com/read/29107780/cd-isotope-fractionation-during-sulfide-mineral-weathering-in-the-fule-zn-pb-cd-deposit-yunnan-province-southwest-china
#7
Chuanwei Zhu, Hanjie Wen, Yuxu Zhang, Runsheng Yin, Christophe Cloquet
Zinc (Zn)-Lead (Pb) deposits are generally rich in cadmium (Cd), and the weathering of sulfide minerals in such deposits results in large releases of Cd into the environment. From an environmental and public health standpoint, understanding Cd sources and cycling is critical to identifying potential hazards to humans. In this study, the Cd isotope compositions (expressed as δ(114/110)Cd) of secondary minerals such as anglesite (-0.57±0.03‰; 2S.D.), granular smithsonite (0.04±0.14‰; 2S.D.), layered smithsonite (0...
November 3, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29071853/-guizhi-fuling-capsule-pill-treatment-for-chronic-pelvic-inflammatory-disease%C3%AF-a-systematic-review-of-randomized-clinical-trials
#8
Li-Shuang Zhang, Feng-Wen Yang, Jun-Hua Zhang, Wen-Ke Zheng, Ming-Yan Zhang, Yue Li, Hong-Jie Zhao
This systematic review aims to systematically evaluate the efficacy and safety of Guizhi Fuling Capsule/Pill on the treatment of chronic pelvic inflammatory disease. We searched CNKI datebases,WanFang,SinoMed,PubMed,Embase,The Cochrane Library from the inception to February 2017,to collect randomized controlled trials(RCTs)of Guizhi Fuling Capsule/Pill in treating chronic pelvic inflammation disease.Two reviewers independently screened literature,extracted date and assessed the risk of bias of included studies...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28975875/education-in-twins-and-their-parents-across-birth-cohorts-over-100-years-an-individual-level-pooled-analysis-of-42-twin-cohorts
#9
Karri Silventoinen, Aline Jelenkovic, Antti Latvala, Reijo Sund, Yoshie Yokoyama, Vilhelmina Ullemar, Catarina Almqvist, Catherine A Derom, Robert F Vlietinck, Ruth J F Loos, Christian Kandler, Chika Honda, Fujio Inui, Yoshinori Iwatani, Mikio Watanabe, Esther Rebato, Maria A Stazi, Corrado Fagnani, Sonia Brescianini, Yoon-Mi Hur, Hoe-Uk Jeong, Tessa L Cutler, John L Hopper, Andreas Busjahn, Kimberly J Saudino, Fuling Ji, Feng Ning, Zengchang Pang, Richard J Rose, Markku Koskenvuo, Kauko Heikkilä, Wendy Cozen, Amie E Hwang, Thomas M Mack, Sisira H Siribaddana, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk, Joohon Sung, Jina Kim, Jooyeon Lee, Sooji Lee, Tracy L Nelson, Keith E Whitfield, Qihua Tan, Dongfeng Zhang, Clare H Llewellyn, Abigail Fisher, S Alexandra Burt, Kelly L Klump, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Sarah E Medland, Nicholas G Martin, Grant W Montgomery, Patrik K E Magnusson, Nancy L Pedersen, Anna K Dahl Aslan, Robin P Corley, Brooke M Huibregtse, Sevgi Y Öncel, Fazil Aliev, Robert F Krueger, Matt McGue, Shandell Pahlen, Gonneke Willemsen, Meike Bartels, Catharina E M van Beijsterveldt, Judy L Silberg, Lindon J Eaves, Hermine H Maes, Jennifer R Harris, Ingunn Brandt, Thomas S Nilsen, Finn Rasmussen, Per Tynelius, Laura A Baker, Catherine Tuvblad, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Margaret Gatz, David A Butler, Paul Lichtenstein, Jack H Goldberg, K Paige Harden, Elliot M Tucker-Drob, Glen E Duncan, Dedra Buchwald, Adam D Tarnoki, David L Tarnoki, Carol E Franz, William S Kremen, Michael J Lyons, José A Maia, Duarte L Freitas, Eric Turkheimer, Thorkild I A Sørensen, Dorret I Boomsma, Jaakko Kaprio
Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for 147,315 and 143,056 twins respectively, from 28 twin cohorts (52% females; 38% MZ twins)...
October 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28959829/-research-progress-on-pharmacological-action-and-clinical-application-of-stephania-tetrandrae-radix
#10
REVIEW
Rong Wang, Teng-Mao Ma, Fei Liu, Hui-Qin Gao
Stephania Tetrandrae Radix is one of the common traditional Chinese medicines, which has bitter and pungent taste as well as cold properties. It can subside edema, get rid of rheumatism and relieve pain. Therefore, it is mainly used for the treatment of rheumatism arthralgia, edema, dysuria, athlete's foot, swollen wet sores and other diseases in traditional Chinese medicine(TCM). Stephania Tetrandrae Radix is mainly composed of dual-benzyl isoquinoline alkaloids, including tetrandrine, fangchinoline and so on...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945046/-analysis-of-on-medication-rules-for-qi-deficiency-and-blood-stasis-syndrome-of-chronic-heart-failure-based-on-data-mining-technology
#11
Qian Wang, Geng-Zhen Yao, Guang-Ming Pan, Jing-Yi Huang, Yi-Pei An, Xu Zou
To analyze the medication features and the regularity of prescriptions of traditional Chinese medicine in treating patients with Qi-deficiency and blood-stasis syndrome of chronic heart failure based on modern literature. In this article, CNKI Chinese academic journal database, Wanfang Chinese academic journal database and VIP Chinese periodical database were all searched from January 2000 to December 2015 for the relevant literature on traditional Chinese medicine treatment for Qi-deficiency and blood-stasis syndrome of chronic heart failure...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944907/placenta%C3%A2-derived-mesenchymal-stem-cells-improve-airway-hyperresponsiveness-and-inflammation-in-asthmatic-rats-by-modulating-the-th17-treg-balance
#12
Yingying Li, Hongbo Li, Yinyin Cao, Fuling Wu, Wenbin Ma, Yuesi Wang, Shuzhen Sun
Mesenchymal stem cells (MSCs) possess reparative and immunoregulatory properties, representing a hope for stem cell‑based treatments. However, the mechanisms by which transplanted MSCs affect T helper (Th)17/regulatory T cell (Treg) balance in asthma patients remain unclear. The aim of the present study was to assess the therapeutic effects of human placenta MSCs (hPMSCs) in asthma, and explore the underlying mechanisms; in addition, the impact of hPMSCs transplantation on Th17/Treg balance in lymph and serum samples from asthmatic animals was evaluated...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28939281/corrigendum-to-systematic-screening-and-characterization-of-multiple-constituents-in-guizhi-fuling-capsule-and-metabolic-profiling-of-bioactive-components-in-rats-using-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#13
Yu Zhang, Yezhe Cheng, Zhongbo Liu, Liqin Ding, Tianyi Qiu, Liwei Chai, Feng Qiu, Zhenzhong Wang, Wei Xiao, Longshan Zhao, Xiaohui Chen
No abstract text is available yet for this article.
September 19, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28939044/corrigendum-to-systematic-screening-and-characterization-of-multiple-constituents-in-guizhi-fuling-capsule-and-metabolic-profiling-of-bioactive-components-in-rats-using-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#14
Yu Zhang, Yezhe Cheng, Zhongbo Liu, Liqin Ding, Tianyi Qiu, Liwei Chai, Feng Qiu, Zhenzhong Wang, Wei Xiao, Longshan Zhao, Xiaohui Chen
No abstract text is available yet for this article.
October 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28934662/a-pc-pu-nanoparticle-pu-decellularized-scaffold-composite-vascular-patch-synergistically-optimized-overall-performance-promotes-endothelialization
#15
Jun Zhang, Cheng Liu, Fuling Feng, Dawei Wang, Shuaishuai Lu, Guo Wei, Hong Mo, Tong Qiao
Composite vascular patches have gained increasingly attention due to the limited availability of autologous patches (vascular graft materials made from the blood vessels of the same recipient), the lack of growth capability of nonautologous patches (vascular graft materials made from the blood vessels of a different donor) and the disadvantages of synthetic patches. In this study, we report a highly biocompatible phosphatidylcholine-polyurethane nanoparticle/polyurethane/decellularized scaffold composite vascular patch (PCVP)...
September 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28915709/the-prognostic-value-of-long-noncoding-rnas-in-prostate-cancer-a-systematic-review-and-meta-analysis
#16
REVIEW
Weijie Ma, Xi Chen, Lu Ding, Jianhong Ma, Wei Jing, Tian Lan, Haseeb Sattar, Yongchang Wei, Fuling Zhou, Yufeng Yuan
The abnormally expressed LncRNAs played irreplaceable roles in the prognosis of prostate cancer (PCa). Therefore, we conducted this systematic review and meta-analysis to summarize the association between the expression of LncRNAs, prognosis and clinicopathology of PCa. 18 eligible studies were recruited into our analysis, including 18 on prognosis and 9 on clinicopathological features. Results indicated that aberrant expression of LncRNAs was significantly associated with biochemical recurrence-free survival (BCR-FS) (HR = 1...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28906007/intergrated-metabonomic-study-of-the-effects-of-guizhi-fuling-capsule-intervention-on-primary-dysmenorrheal-using-rp-uplc-ms-complementary-with-hilic-uplc-ms-technique
#17
Lang Lang, Zhaorui Meng, Lan Sun, Wei Xiao, Longshan Zhao, Zhili Xiong
Guizhi Fuling capsule (GFC), developed from the traditional Chinese prescription of Guizhi Fuling Wan, has been commonly used for the treatment of primary dysmenorrheal (PD). However, the intervention effective mechanism in vivo has not been well elucidated. In this study, an integrated plasma metabonomic strategy based on RP-UPLC-MS coupled with HILIC-UPLC-MS technique has been developed to investigate the global therapeutic effects and intervention mechanisms of Guizhi Fuling capsule (GFC) on dysmenorrhea rats induced by oxytocin...
September 14, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28871942/-%C3%AE-secretase-inhibitor-mw167-reduces-the-level-of-gata3-in-peripheral-blood-mononuclear-cells-in-children-with-respiratory-syncytial-virus-bronchiolitis
#18
Liangxiao Liu, Fuling Wu, Xuejing Zhang, Haiying Wang
Objective To study the changes of GATA3 in peripheral blood mononuclear cells (PBMCs) of children with respiratory syncytial virus (RSV) bronchiolitis after γ-secretase inhibitor (GSI) MW167 blocks Notch signaling. Methods The study enrolled 30 patients with RSV bronchiolitis and 25 normal controls. PBMCs were separated and divided into normal control group, RSV group, and MW167 treated group. The level of interleukin-4 (IL-4) in supernatant was detected by ELISA; level of GATA3 mRNA was determined by real-time fluorescent quantitative PCR; and the expressions of Notch1 intracellular domain (NICD) and GATA3 proteins were examined by Western blotting...
August 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28838645/systematic-screening-and-characterization-of-multiple-constituents-in-guizhi-fuling-capsule-and-metabolic-profiling-of-bioactive-components-in-rats-using-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#19
Yu Zhang, Yezhe Cheng, Zhongbo Liu, Liqin Ding, Tianyi Qiu, Liwei Chai, Feng Qiu, Zhenzhong Wang, Wei Xiao, Longshan Zhao, Xiaohui Chen
Guizhi Fuling capsule (GFC), a prestigious traditional Chinese medicinal (TCM) prescription, is efficiently used to treat primary dysmenorrhea in the clinical practice. It's significant to explore the metabolic fate of multiple components in vivo which are responsible for the pharmacological effects but not fully investigated. A rapid and high-throughput method using ultra performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF-MS/MS) was established for systematic investigation on GFC, including GFC chemical compositions, and their absorption and metabolism in rat plasma, urine, uterus and brain after oral administration of GFC...
September 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28822198/-comparison-between-ye-tianshi-and-xue-shengbai-in-treatment-of-distention-with-damp-heat
#20
Yu-Juan Li, Xiao-Yu Liu, Hou-Wang Jiang, Hong-Pei Li, Lian-Yu Xiao, Yan-Song Zhao
Ye Tianshi and Xue Shengbai were both epidemic febrile diseases specialists in same time of Qing dynasty. The Traditional Chinese Medicine Inheritance Support System was used to compare and analyze the therapeutic characteristics of these two specialists in treating damp-heat type fullness or distension in stomach. Distension is commonly caused by qi stagnation accompanied with damp-heat from internal and external factors. In treatment, separation of damp and heat and removing dampness and heat from sanjiao separately were their common therapeutic principles...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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