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https://www.readbyqxmd.com/read/28214839/t-cell-associated-immunotherapy-for-hepatocellular-carcinoma
#1
Weijie Ma, Long Wu, Fuling Zhou, Zhenfei Hong, Yufeng Yuan, Zhisu Liu
Hepatocellular carcinoma (HCC) is one of the most common malignant diseases worldwide with limited therapeutic options. Accumulating evidences suggest that immunotherapy could be a promising option for treating HCC. T cell-associated immunotherapy lights up the hope for the improvement of complementary approach to conventional HCC treatments, which needs further research to consummate the clinical consequences. The present work reviewed several T cells associated cellular immunotherapies for HCC, including immune checkpoint blockade, gene-engineered T cells, bispecific T cell engagers, and so on...
February 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28164471/porous-zirconium-furandicarboxylate-microspheres-for-efficient-redox-conversion-of-biofuranics
#2
Hu Li, Xiaofang Liu, Tingting Yang, Wenfeng Zhao, Shunmugavel Saravanamurugan, Song Yang
Biofuranic compounds, typically derived from C5 and C6 carbohydrates, have been extensively studied as promising alternatives to fossil fule-based chemicals. The present work reports the simple assembly of bio-based 2,5-furandicarboxylic acid (FDCA) with different metal ions to prepare a range of metal-FDCA hybrids under hydrothermal conditions, which were demonstrated to have porous structure and acid-base bifunctionality. Especially, Zr-FDCA-T showed microspheric structure, high thermostability (ca. 400 ºC), ampliative average pore diameters (ca...
February 6, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28120217/current-treatment-options-of-t-cell-associated-immunotherapy-in-multiple-myeloma
#3
REVIEW
Hailing Liu, Yunbao Pan, Shan Meng, Wanggang Zhang, Fuling Zhou
Multiple myeloma (MM) is a complex disease and is presently an incurable malignant plasma cell tumor. Although the introduction of proteasome inhibitor and the immunomodulators markedly improved the effect of myeloma therapy, most patients still suffer from relapse even with an initially effective therapy. Accumulating evidence suggests that immunotherapy is a promising option in treating MM. And T cell plays crucial role through inducing sustained immune response in vivo in the immunotherapy of tumors. In this article, we will discuss progress of several T cell-based immunotherapies with insight into how they eradicate myeloma cells and their disadvantages...
January 24, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/28097890/novel-1-2-pyrimidin-2-yl-piperazine-derivatives-as-selective-monoamine-oxidase-mao-a-inhibitors
#4
Betül Kaya, Leyla Yurttaş, Begüm Nurpelin Sağlik, Serkan Levent, Yusuf Özkay, Zafer Asim Kaplancikli
In the present study, a new series of 2-[4-(pyrimidin-2-yl)piperazin-1-yl]-2-oxoethyl 4-substituted piperazine-1-carbodithioate derivatives (2a-n) were synthesized and screened for their monoamine oxidase A and B inhibitory activity. The structures of compounds were elucidated using spectroscopic methods and some physicochemical properties of new compounds were predicted using Molinspiration and MolSoft programs. Compounds 2-[4-(pyrimidin-2-yl)piperazin-1-yl]-2-oxoethyl 4-(4-nitrophenyl)piperazine-1-carbodithioate (2j) and 2-[4-(pyrimidin-2-yl)piperazin-1-yl]-2-oxoethyl 4-benzhydrylpiperazine-1-carbodithioate (2m) exhibited selective MAO-A inhibitory activity with IC50 = 23...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28077330/dehydropachymic-acid-decreases-bafilomycin-a1-induced-%C3%AE-amyloid-accumulation-in-pc12-cells
#5
Mengyao Yu, Xiaoyan Xu, Nan Jiang, Wei Wei, Fang Li, Liming He, Xia Luo
ETHNOPHARMACOLOGICAL RELEVANCE: Fuling, the sclerotium of Poria cocos, was frequently used in traditional Chinese medicine (TCM) formulae for Alzheimer's disease (AD) intervention over the past 10 centuries. And its extracts exhibited significant effects in both cellular and animal models of AD in previous studies. However, its mechanisms on prevention and treatment of AD have not been well elucidated yet. AIM OF THE STUDY: To investigate the effect and corresponding mechanisms of dehydropachymic acid, which is one of the major triterpenes in Poria cocos, on the clearance of β-Amyloid accumulation in bafilomycin A1 induced PC12 cells...
January 7, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27976519/tetraphenylmethane-arylamine-hole-transporting-materials-for-perovskite-solar-cells
#6
Xuepeng Liu, Fantai Kong, Tai Cheng, Wangchao Chen, Zhao'ao Tan, Ting Yu, Fuling Guo, Jian Chen, Jianxi Yao, Songyuan Dai
A new class of hole transporting materials containing tetraphenylmethane core have been developed. After thermal, charge carrier mobility and contact angle tests, it is found that TPA-TPM show a higher glass transition temperature and larger water contact angle than spiro-OMeTAD with comparable hole mobility. Photoluminescence and impedance spectroscopy study indicate that TPA-TPM own comparable hole extraction ability with spiro-OMeTAD. Scanning electron microscope and atomic force microscopy results suggest that TPA-TPM show a smooth surface...
December 15, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27895695/the-effects-of-guizhi-fuling-capsule-drug-serum-on-uterine-leiomyoma-cells-and-its-mechanism
#7
Qi Shen, Weijing Ye, Xiaoli Hu, Chuchu Zhao, Lulu Zhou, Xueqiong Zhu
Aims. To observe the effects of Guizhi Fuling Capsule (GZFLC) drug serum on uterine leiomyoma cells and explore its mechanism. Main Methods. Sixty Sprague Dawley rats were randomly divided into two groups (normal saline lavage group and GZFLC lavage group), then, respectively, blank serum and GZFLC drug serum were collected, and finally human uterine leiomyoma cells were treated. Human leiomyoma tissues were collected from 20 patients who underwent uterine leiomyomas operations, and leiomyoma cells were primary cultured...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27884853/gyejibongneyong-hwan-a-herbal-medicine-for-the-treatment-of-dysmenorrhoea-with-uterine-fibroids-a-protocol-for-a-randomised-controlled-trial
#8
Jeeyoun Jung, Ju Ah Lee, Mi Mi Ko, Sooseong You, Eunhee Lee, Jiae Choi, Byoung-Kab Kang, Myeong Soo Lee
INTRODUCTION: Gyejibongneyong-hwan (GBH), or the Guizhi Fuling Formula in Chinese, is widely used to treat uterine fibroids in East Asian countries including Korea, China and Japan. This study will assess the efficacy and safety of the GBH formula for the treatment of dysmenorrhoea. METHODS AND ANALYSIS: This study will be a randomised double-blind controlled trial with two parallel arms: the GBH group and the placebo group. This trial will recruit 38 women between 18 and 45 years of age with secondary dysmenorrhoea with uterine fibroids...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27859967/slow-carbon-and-nutrient-accumulation-in-trees-established-following-fire-exclusion-in-the-southwestern-united-states
#9
Jason P Kaye, Margot W Kaye, Stephen C Hart, W Wallace Covington, Peter Z Fulé
Increasing tree density that followed fire exclusion after the 1880s in the southwestern United States may have also altered nutrient cycles and led to a carbon (C) sink that constitutes a significant component of the U.S. C budget. Yet, empirical data quantifying century-scale changes in C or nutrients due to fire exclusion are rare. We used tree-ring reconstructions of stand structure from five ponderosa pine-dominated sites from across northern Arizona to compare live tree C, nitrogen (N), and phosphorus (P) storage between the 1880s and 1990s...
December 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27854047/neuroprotection-of-gueichih-fuling-wan-on-cerebral-ischemia-reperfusion-injury-in-streptozotocin-induced-hyperglycemic-rats-via-the-inhibition-of-the-cellular-apoptosis-pathway-and-neuroinflammation
#10
Yuh-Fung Chen, Kuo-Jen Wu, Wei-Shih Huang, Yow-Wen Hsieh, Yu-Wen Wang, Huei-Yann Tsai, Ming-Ming Lee
BACKGROUND: Risks of stroke link with complications of hyperglycemia. Gueichih-Fuling-Wan (GFW), according to Chinese Medical Code literature, has the promotion of blood circulation and attenuates the swollen plot. Recent pharmacological studies have pointed out its efficacy in patients with cerebral ischemia or diabetes. Therefore, this study determined whether GFW has the protection against cerebral ischemia/ reperfusion (I/R) injury in streptozotocin (STZ)-induced hyperglycemic rats and LPS-induced inflammation in BV-2 microglial cells...
December 2016: BioMedicine
https://www.readbyqxmd.com/read/27796393/the-effect-of-geniste-on-a%C3%AE-25-35-induced-pc12-cell-apoptosis-through-the-jnk-dependent-fas-pathway
#11
Yaojie Zheng, Fuling You, Qiao Li, Jingrong Chen, Hong Yang
The β-amyloid protein (Aβ) is considered to be the key factor for inducing Alzheimer's disease (AD). In recent years, the neuroprotective effects of genistein have drawn increasing attention. However, the molecular mechanisms of GEN (genistein) against Aβ are unclear. In the present study, we investigated the inhibitory effects of GEN on Aβ25-35-induced apoptosis in cultured PC12 cells and the related signaling pathway. Our data show that GEN significantly inhibited Aβ25-35-induced apoptosis of PC12 cells...
November 9, 2016: Food & Function
https://www.readbyqxmd.com/read/27776968/downregulation-of-long-non-coding-rnas-jpx-and-xist-is-associated-with-the-prognosis-of-hepatocellular-carcinoma
#12
Weijie Ma, Haitao Wang, Wei Jing, Fuling Zhou, Lei Chang, Zhenfei Hong, Hailing Liu, Zhisu Liu, Yufeng Yuan
BACKGROUND: The expression profiles and biological relevance of long non-coding RNA XIST and its activator JPX in hepatocellular carcinoma (HCC) are not well elucidated. We measured JPX and XIST expression levels in HCC, evaluated their clinical significance in HCC progression, and verified their potential as biomarkers for diagnosing HCC. METHODS: JPX and XIST expression in 68 HCC tissues and adjacent normal tissues were evaluated by quantitative reverse transcription-PCR (qRT-PCR); their association with pathologic features and overall survival was analyzed...
October 21, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27738441/efficacy-of-compound-kushen-injection-in-combination-with-induction-chemotherapy-for-treating-adult-patients-newly-diagnosed-with-acute-leukemia
#13
Honglei Tu, Bo Lei, Shan Meng, Hailing Liu, Yongchang Wei, Aili He, Wanggang Zhang, Fuling Zhou
We assessed the clinical effectiveness and safety of CKI (compound Kushen injection) plus standard induction chemotherapy for treating adult acute leukemia (AL). We randomly assigned 332 patients with newly diagnosed AL to control (n = 165, receiving DA (daunorubicin and cytarabine) or hyper-CVAD (fractionated cyclophosphamide, doxorubicin, vincristine, and dexamethasone)) or treatment (n = 167, receiving CKI and DA or hyper-CVAD) groups. Posttreatment, treatment group CD3+, CD4+, CD4+/CD8+, natural killer (NK) cell, and immunoglobulin (IgG, IgA, and IgM) levels were significantly higher than those of the control group (p < 0...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27708635/the-kinome-of-edible-and-medicinal-fungus-wolfiporia-cocos
#14
Wei Wei, Shaohua Shu, Wenjun Zhu, Ying Xiong, Fang Peng
Wolfiporia cocos is an edible and medicinal fungus that grows in association with pine trees, and its dried sclerotium, known as Fuling in China, has been used as a traditional medicine in East Asian countries for centuries. Nearly 10% of the traditional Chinese medicinal preparations contain W. cocos. Currently, the commercial production of Fuling is limited because of the lack of pine-based substrate and paucity of knowledge about the sclerotial development of the fungus. Since protein kinase (PKs) play significant roles in the regulation of growth, development, reproduction, and environmental responses in filamentous fungi, the kinome of W...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27683510/herbal-medicine-gyejibongneyong-hwan-for-treating-primary-dysmenorrhoea-a-protocol-for-a-systematic-review-of-randomised-controlled-trials
#15
Ju Ah Lee, Sunju Park, Jeeyoun Jung, Ji Hee Jun, Jiae Choi, Myeong Soo Lee
INTRODUCTION: Gyejibongneyong-hwan (GBH), also known as Guizhi Fuling formula, and is widely used for uterine fibroids in East Asian countries. Many clinical trials assessing the efficacy and safety of GBH formula for the treatment of dysmenorrhoea have been reported. This review will assess the clinical evidence for and against the use of GBH formula as a treatment for dysmenorrhoea. It will also discuss the proposed mechanism(s) that could link herbal medicine to improvements in dysmenorrhoea...
2016: BMJ Open
https://www.readbyqxmd.com/read/27666407/depression-accelerates-the-development-of-gastric-cancer-through-reactive-oxygen-species%C3%A2-activated-abl1-review
#16
Tianhe Huang, Fuling Zhou, Feng Wang-Johanning, Kejun Nan, Yongchang Wei
Depression is a common symptom among gastric cancer (GC) patients and serves as a potential indication of poor prognosis and advanced cancer clinical stage. However, the molecular mechanism of depression‑associated poor prognoses of GC patients remains unclear. Recent studies have revealed that GC patients with depression are under high levels of oxidative stress (OS) status that is accompanied by the dysfunction of numerous proto‑oncogenes, including the ABL proto‑oncogene 1 (ABL1), which is a non‑receptor tyrosine kinase...
November 2016: Oncology Reports
https://www.readbyqxmd.com/read/27633118/micrornas-serve-as-a-bridge-between-oxidative-stress-and-gastric-cancer-review
#17
Tianhe Huang, Feng Wang-Johanning, Fuling Zhou, Herbert Kallon, Yongchang Wei
Gastric cancer (GC) remains one of the most prevalent tumors worldwide and affects human health due to its high morbidity and mortality. Mechanisms underlying occurrence and development of GC have been widely studied. Studies have revealed reactive oxygen species (ROS) generated by cells under oxidative stress (OS) are involved in gastric tumorigenesis, and modulate expression of microRNAs (miRs). As such, miRs have been shown to be associated with OS-related GC. Given the association of OS and miRs in development of GC, this review aims to summarize the relationship between miRs and OS and their role in GC development...
November 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27557521/activation-of-herv-k-env-protein-is-essential-for-tumorigenesis-and-metastasis-of-breast-cancer-cells
#18
Fuling Zhou, Ming Li, Yongchang Wei, Kevin Lin, Yue Lu, Jianjun Shen, Gary L Johanning, Feng Wang-Johanning
Human endogenous retrovirus type K (HERV-K) Env protein was previously demonstrated to be overexpressed in human breast cancer (BC) cells and tissues. However, the molecular pathways driving the specific alterations are unknown. We now show that knockdown of its expression with an shRNA (shRNAenv) blocked BC cell proliferation, migration, and invasion. shRNAenv transduction also attenuated the ability of BC cells to form tumors, and notably prevented metastasis. Mechanistically, downregulation of HERV-K blocked expression of tumor-associated genes that included Ras, p-RSK, and p-ERK...
August 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27527657/integrated-identification-qualification-and-quantification-strategy-for-pharmacokinetic-profile-study-of-guizhi-fuling-capsule-in-healthy-volunteers
#19
Yun-Xi Zhong, Xiao-Liang Jin, Shi-Yin Gu, Ying Peng, Ke-Rong Zhang, Bing-Chen Ou-Yang, Yu Wang, Wei Xiao, Zhen-Zhong Wang, Ji-Ye Aa, Guang-Ji Wang, Jian-Guo Sun
Guizhi Fuling capsule (GZFL), a traditional Chinese medicine formulation, is widely used in China to relieve pain from dysmenorrhea and is now in a Phase II clinical trial in the USA. Due to the low exposure of the five main medicative ingredients (amygdalin, cinnamic acid, gallic acid, paeoniflorin and paeonol) of GZFL in human, a strategy was built to qualitatively and quantitatively identify the possible metabolites of GZFL and to describe the pharmacokinetic profiles of GZFL in human. In this strategy, LC-Q-TOF/MS was used to identify and structurally elucidate the possible metabolites of GZFL in vivo; and a time-based metabolite-confirming step (TBMCs) was used to confirm uncertain metabolites...
August 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27506023/-nitrogen-losses-under-the-action-of-different-land-use-types-of-small-catchment-in-three-gorges-region
#20
Cheng-long Chen, Ming Gao, Jiu-pai Ni, De-ti Xie, Hua Deng
As an independent water-collecting area, small catchment is the source of non-point source pollution in Three Gorges Region. Choosing 3 kinds of the most representative land-use types and using them to lay monitoring points of overland runoff within the small catchment of Wangjiagou in Fuling of Three Gorges Region, the author used the samples of surface runoff collected through the twelve natural rainfalls from May to December to analyze the feature of spatial-temporal change of Nitrogen's losses concentrations under the influence of different land use types and the hillslopes and small catchments composed by those land use types, revealing the relation between different land-use types and Nitrogen's losses of small catchments in Three Gorges Region...
May 15, 2016: Huan Jing Ke Xue= Huanjing Kexue
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