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https://www.readbyqxmd.com/read/28337842/halogenated-briarane-diterpenes-with-acetyl-migration-from-the-gorgonian-coral-junceella-fragilis
#1
Wei Cheng, Xiaodan Li, Fuling Yin, Leen van Ofwegen, Wenhan Lin
Chemical examination of the gorgonian coral Junceella fragilis resulted in the isolation of four pairs of acetyl isomers belonging to briarane diterpenoids, including five new compounds. Their structures were determined on the basis of extensive spectroscopic (IR, MS, NMR and single-crystal X-ray diffraction) analysis in association with the chemical conversion. Each pair of isomers featured by dynamical interconversion through as acetyl migration in 1,2-diol, which was postulated to be generated under the formation of a cyclic orthoacetate intermediate...
March 24, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28316984/leptin-leprb-expressed-in-gastric-cancer-patients-and-related-to-cancer-related-depression
#2
Yunbao Pan, Fuling Zhou, Chenyan He, Lingyun Hui, Tianhe Huang, Yongchang Wei
Depression is the most common psychiatric disorder among cancer patients. Studies have not only highlighted that leptin and its receptor (LepRb) are independent poor prognostic factors in gastric cancer (GC) patients but also shown that the leptin-LepRb is necessary for antidepressant-like behaviors. In this study, we examined the serum and tissue leptin-LepRb expression in GC patients. Enzyme-linked immunosorbent assay showed that depressive GC patients had significantly higher serum leptin-LepRb than healthy donors...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28270496/jab1-csn5-thioredoxin-signaling-in-relapsed-acute-monocytic-leukemia-under-oxidative-stress
#3
Fuling Zhou, Yunbao Pan, Yongchang Wei, Ronghua Zhang, Gaigai Bai, Qiuju Shen, Shan Meng, Xiao-Feng Le, Michael Andreeff, Francois X Claret
PURPOSE: High levels of ROS and ineffective antioxidant systems contribute to oxidative stress, which affects the function of hematopoietic cells in acute myeloid leukemia (AML); however, the mechanisms by which ROS lead to malignant transformation in relapsed AML-M5 are not completely understood. We hypothesized that alterations in intracellular ROS would trigger AML-M5 relapse by activating the intrinsic pathway. EXPERIMENTAL DESIGN: We studied ROS levels and conducted JAB1/COPS5 and TRX gene expression analyses with blood samples obtained from 60 matched AML-M5 patients at diagnosis and relapse and conducted mechanism studies of Jab1's regulation of Trx in leukemia cell lines...
March 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28248091/high-density-single-layer-coating-of-gold-nanoparticles-onto-multiple-substrates-by-using-an-intrinsically-disordered-protein-of-%C3%AE-synuclein-for-nanoapplications
#4
Ghibom Bhak, Junghee Lee, Chang-Hyun Kim, Dong Young Chung, Jin Hyoun Kang, Soojung Oh, Jungsup Lee, Jin Soo Kang, Ji Mun Yoo, Jee Eun Yang, Kun Yil Rhoo, Sunghak Park, Somin Lee, Ki Tae Nam, Noo Li Jeon, Jyongsik Jang, Byung Hee Hong, Yung-Eun Sung, Myung-Han Yoon, Seung R Paik
Functional graffiti of nanoparticles onto target surface is an important issue in the development of nanodevices. A general strategy has been introduced here to decorate chemically diverse substrates with gold nanoparticles (AuNPs) in the form of a close-packed single layer by using an omni-adhesive protein of α-synuclein (αS) as conjugated with the particles. Since the adsorption was highly sensitive to pH, the amino acid sequence of αS exposed from the conjugates and its conformationally disordered state capable of exhibiting structural plasticity are considered to be responsible for the single-layer coating over diverse surfaces...
March 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28244703/association-between-fruit-vegetable-seafood-and-dairy-intake-and-a-reduction-in-the-prevalence-of-type-2-diabetes-in-qingdao-china
#5
Jiwei Liang, Yanlei Zhang, Aili Xue, Jianping Sun, Xin Song, Bai Xue, Fuling Ji, Weiguo Gao, Liang He, Zengchang Pang, Qing Qiao, Feng Ning
BACKGROUND AND OBJECTIVES: Fruit, vegetable, seafood, and dairy intake may reduce the risk of type 2 diabetes, but this relationship is unclear. We aimed to examine the associations between fruit, vegetable, seafood, and dairy intake and type 2 diabetes prevalence in a Chinese population. METHODS AND STUDY DESIGN: A total of 4,343 individuals aged 35-74 years participated in a population-based cross-sectional study in Qingdao, China. The frequency and quantity of fruit, vegetable, seafood, and dairy intake were determined using a standard food frequency questionnaire...
March 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28214839/t-cell-associated-immunotherapy-for-hepatocellular-carcinoma
#6
Weijie Ma, Long Wu, Fuling Zhou, Zhenfei Hong, Yufeng Yuan, Zhisu Liu
Hepatocellular carcinoma (HCC) is one of the most common malignant diseases worldwide with limited therapeutic options. Accumulating evidences suggest that immunotherapy could be a promising option for treating HCC. T cell-associated immunotherapy lights up the hope for the improvement of complementary approach to conventional HCC treatments, which needs further research to consummate the clinical consequences. The present work reviewed several T cells associated cellular immunotherapies for HCC, including immune checkpoint blockade, gene-engineered T cells, bispecific T cell engagers, and so on...
February 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28164471/porous-zirconium-furandicarboxylate-microspheres-for-efficient-redox-conversion-of-biofuranics
#7
Hu Li, Xiaofang Liu, Tingting Yang, Wenfeng Zhao, Shunmugavel Saravanamurugan, Song Yang
Biofuranic compounds, typically derived from C5 and C6 carbohydrates, have been extensively studied as promising alternatives to fossil fule-based chemicals. The present work reports the simple assembly of bio-based 2,5-furandicarboxylic acid (FDCA) with different metal ions to prepare a range of metal-FDCA hybrids under hydrothermal conditions, which were demonstrated to have porous structure and acid-base bifunctionality. Especially, Zr-FDCA-T showed microspheric structure, high thermostability (ca. 400 ºC), ampliative average pore diameters (ca...
February 6, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28120217/current-treatment-options-of-t-cell-associated-immunotherapy-in-multiple-myeloma
#8
REVIEW
Hailing Liu, Yunbao Pan, Shan Meng, Wanggang Zhang, Fuling Zhou
Multiple myeloma (MM) is a complex disease and is presently an incurable malignant plasma cell tumor. Although the introduction of proteasome inhibitor and the immunomodulators markedly improved the effect of myeloma therapy, most patients still suffer from relapse even with an initially effective therapy. Accumulating evidence suggests that immunotherapy is a promising option in treating MM. And T cell plays crucial role through inducing sustained immune response in vivo in the immunotherapy of tumors. In this article, we will discuss progress of several T cell-based immunotherapies with insight into how they eradicate myeloma cells and their disadvantages...
January 24, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/28097890/novel-1-2-pyrimidin-2-yl-piperazine-derivatives-as-selective-monoamine-oxidase-mao-a-inhibitors
#9
Betül Kaya, Leyla Yurttaş, Begüm Nurpelin Sağlik, Serkan Levent, Yusuf Özkay, Zafer Asim Kaplancikli
In the present study, a new series of 2-[4-(pyrimidin-2-yl)piperazin-1-yl]-2-oxoethyl 4-substituted piperazine-1-carbodithioate derivatives (2a-n) were synthesized and screened for their monoamine oxidase A and B inhibitory activity. The structures of compounds were elucidated using spectroscopic methods and some physicochemical properties of new compounds were predicted using Molinspiration and MolSoft programs. Compounds 2-[4-(pyrimidin-2-yl)piperazin-1-yl]-2-oxoethyl 4-(4-nitrophenyl)piperazine-1-carbodithioate (2j) and 2-[4-(pyrimidin-2-yl)piperazin-1-yl]-2-oxoethyl 4-benzhydrylpiperazine-1-carbodithioate (2m) exhibited selective MAO-A inhibitory activity with IC50 = 23...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28077330/dehydropachymic-acid-decreases-bafilomycin-a1-induced-%C3%AE-amyloid-accumulation-in-pc12-cells
#10
Mengyao Yu, Xiaoyan Xu, Nan Jiang, Wei Wei, Fang Li, Liming He, Xia Luo
ETHNOPHARMACOLOGICAL RELEVANCE: Fuling, the sclerotium of Poria cocos, was frequently used in traditional Chinese medicine (TCM) formulae for Alzheimer's disease (AD) intervention over the past 10 centuries. And its extracts exhibited significant effects in both cellular and animal models of AD in previous studies. However, its mechanisms on prevention and treatment of AD have not been well elucidated yet. AIM OF THE STUDY: To investigate the effect and corresponding mechanisms of dehydropachymic acid, which is one of the major triterpenes in Poria cocos, on the clearance of β-Amyloid accumulation in bafilomycin A1 induced PC12 cells...
January 7, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27976519/tetraphenylmethane-arylamine-hole-transporting-materials-for-perovskite-solar-cells
#11
Xuepeng Liu, Fantai Kong, Tai Cheng, Wangchao Chen, Zhan'ao Tan, Ting Yu, Fuling Guo, Jian Chen, Jianxi Yao, Songyuan Dai
A new class of hole-transporting materials (HTM) containing tetraphenylmethane (TPM) core have been developed. After thermal, charge carrier mobility, and contact angle tests, it was found that TPA-TPM (TPA: arylamine derivates side group) showed higher glass-transition temperature and larger water-contact angle than spiro-OMeTAD with comparable hole mobility. Photoluminescence and impedance spectroscopy studies indicate that TPA-TPM's hole-extraction ability is comparable to that of spiro-OMeTAD. SEM and AFM results suggest that TPA-TPM has a smooth surface...
December 15, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27895695/the-effects-of-guizhi-fuling-capsule-drug-serum-on-uterine-leiomyoma-cells-and-its-mechanism
#12
Qi Shen, Weijing Ye, Xiaoli Hu, Chuchu Zhao, Lulu Zhou, Xueqiong Zhu
Aims. To observe the effects of Guizhi Fuling Capsule (GZFLC) drug serum on uterine leiomyoma cells and explore its mechanism. Main Methods. Sixty Sprague Dawley rats were randomly divided into two groups (normal saline lavage group and GZFLC lavage group), then, respectively, blank serum and GZFLC drug serum were collected, and finally human uterine leiomyoma cells were treated. Human leiomyoma tissues were collected from 20 patients who underwent uterine leiomyomas operations, and leiomyoma cells were primary cultured...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27884853/gyejibongneyong-hwan-a-herbal-medicine-for-the-treatment-of-dysmenorrhoea-with-uterine-fibroids-a-protocol-for-a-randomised-controlled-trial
#13
Jeeyoun Jung, Ju Ah Lee, Mi Mi Ko, Sooseong You, Eunhee Lee, Jiae Choi, Byoung-Kab Kang, Myeong Soo Lee
INTRODUCTION: Gyejibongneyong-hwan (GBH), or the Guizhi Fuling Formula in Chinese, is widely used to treat uterine fibroids in East Asian countries including Korea, China and Japan. This study will assess the efficacy and safety of the GBH formula for the treatment of dysmenorrhoea. METHODS AND ANALYSIS: This study will be a randomised double-blind controlled trial with two parallel arms: the GBH group and the placebo group. This trial will recruit 38 women between 18 and 45 years of age with secondary dysmenorrhoea with uterine fibroids...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27859967/slow-carbon-and-nutrient-accumulation-in-trees-established-following-fire-exclusion-in-the-southwestern-united-states
#14
Jason P Kaye, Margot W Kaye, Stephen C Hart, W Wallace Covington, Peter Z Fulé
Increasing tree density that followed fire exclusion after the 1880s in the southwestern United States may have also altered nutrient cycles and led to a carbon (C) sink that constitutes a significant component of the U.S. C budget. Yet, empirical data quantifying century-scale changes in C or nutrients due to fire exclusion are rare. We used tree-ring reconstructions of stand structure from five ponderosa pine-dominated sites from across northern Arizona to compare live tree C, nitrogen (N), and phosphorus (P) storage between the 1880s and 1990s...
December 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27854047/neuroprotection-of-gueichih-fuling-wan-on-cerebral-ischemia-reperfusion-injury-in-streptozotocin-induced-hyperglycemic-rats-via-the-inhibition-of-the-cellular-apoptosis-pathway-and-neuroinflammation
#15
Yuh-Fung Chen, Kuo-Jen Wu, Wei-Shih Huang, Yow-Wen Hsieh, Yu-Wen Wang, Huei-Yann Tsai, Ming-Ming Lee
BACKGROUND: Risks of stroke link with complications of hyperglycemia. Gueichih-Fuling-Wan (GFW), according to Chinese Medical Code literature, has the promotion of blood circulation and attenuates the swollen plot. Recent pharmacological studies have pointed out its efficacy in patients with cerebral ischemia or diabetes. Therefore, this study determined whether GFW has the protection against cerebral ischemia/ reperfusion (I/R) injury in streptozotocin (STZ)-induced hyperglycemic rats and LPS-induced inflammation in BV-2 microglial cells...
December 2016: BioMedicine
https://www.readbyqxmd.com/read/27796393/the-effect-of-geniste-on-a%C3%AE-25-35-induced-pc12-cell-apoptosis-through-the-jnk-dependent-fas-pathway
#16
Yaojie Zheng, Fuling You, Qiao Li, Jingrong Chen, Hong Yang
The β-amyloid protein (Aβ) is considered to be the key factor for inducing Alzheimer's disease (AD). In recent years, the neuroprotective effects of genistein have drawn increasing attention. However, the molecular mechanisms of GEN (genistein) against Aβ are unclear. In the present study, we investigated the inhibitory effects of GEN on Aβ25-35-induced apoptosis in cultured PC12 cells and the related signaling pathway. Our data show that GEN significantly inhibited Aβ25-35-induced apoptosis of PC12 cells...
November 9, 2016: Food & Function
https://www.readbyqxmd.com/read/27776968/downregulation-of-long-non-coding-rnas-jpx-and-xist-is-associated-with-the-prognosis-of-hepatocellular-carcinoma
#17
Weijie Ma, Haitao Wang, Wei Jing, Fuling Zhou, Lei Chang, Zhenfei Hong, Hailing Liu, Zhisu Liu, Yufeng Yuan
BACKGROUND: The expression profiles and biological relevance of long non-coding RNA XIST and its activator JPX in hepatocellular carcinoma (HCC) are not well elucidated. We measured JPX and XIST expression levels in HCC, evaluated their clinical significance in HCC progression, and verified their potential as biomarkers for diagnosing HCC. METHODS: JPX and XIST expression in 68 HCC tissues and adjacent normal tissues were evaluated by quantitative reverse transcription-PCR (qRT-PCR); their association with pathologic features and overall survival was analyzed...
October 21, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27738441/efficacy-of-compound-kushen-injection-in-combination-with-induction-chemotherapy-for-treating-adult-patients-newly-diagnosed-with-acute-leukemia
#18
Honglei Tu, Bo Lei, Shan Meng, Hailing Liu, Yongchang Wei, Aili He, Wanggang Zhang, Fuling Zhou
We assessed the clinical effectiveness and safety of CKI (compound Kushen injection) plus standard induction chemotherapy for treating adult acute leukemia (AL). We randomly assigned 332 patients with newly diagnosed AL to control (n = 165, receiving DA (daunorubicin and cytarabine) or hyper-CVAD (fractionated cyclophosphamide, doxorubicin, vincristine, and dexamethasone)) or treatment (n = 167, receiving CKI and DA or hyper-CVAD) groups. Posttreatment, treatment group CD3+, CD4+, CD4+/CD8+, natural killer (NK) cell, and immunoglobulin (IgG, IgA, and IgM) levels were significantly higher than those of the control group (p < 0...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27708635/the-kinome-of-edible-and-medicinal-fungus-wolfiporia-cocos
#19
Wei Wei, Shaohua Shu, Wenjun Zhu, Ying Xiong, Fang Peng
Wolfiporia cocos is an edible and medicinal fungus that grows in association with pine trees, and its dried sclerotium, known as Fuling in China, has been used as a traditional medicine in East Asian countries for centuries. Nearly 10% of the traditional Chinese medicinal preparations contain W. cocos. Currently, the commercial production of Fuling is limited because of the lack of pine-based substrate and paucity of knowledge about the sclerotial development of the fungus. Since protein kinase (PKs) play significant roles in the regulation of growth, development, reproduction, and environmental responses in filamentous fungi, the kinome of W...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27683510/herbal-medicine-gyejibongneyong-hwan-for-treating-primary-dysmenorrhoea-a-protocol-for-a-systematic-review-of-randomised-controlled-trials
#20
Ju Ah Lee, Sunju Park, Jeeyoun Jung, Ji Hee Jun, Jiae Choi, Myeong Soo Lee
INTRODUCTION: Gyejibongneyong-hwan (GBH), also known as Guizhi Fuling formula, and is widely used for uterine fibroids in East Asian countries. Many clinical trials assessing the efficacy and safety of GBH formula for the treatment of dysmenorrhoea have been reported. This review will assess the clinical evidence for and against the use of GBH formula as a treatment for dysmenorrhoea. It will also discuss the proposed mechanism(s) that could link herbal medicine to improvements in dysmenorrhoea...
2016: BMJ Open
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