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https://www.readbyqxmd.com/read/29916534/aberrantly-expressed-genes-and-mirnas-in-human-hypopharyngeal-squamous-cell-carcinoma-based-on-rna%C3%A2-sequencing-analysis
#1
Hu Li, Fuling Wang, Yonghua Fei, Yanhua Lei, Fengxiang Lu, Ping Guo, Wei Li, Xuehong Xun
The aim of the present study was to investigate the key genes, miRNAs and pathways in hypopharyngeal squamous cell carcinoma (HPSCC) and to elucidate the mechanisms underlying HPSCC development. The gene and microRNA (miRNA) expression profiles of HPSCC tissues and adjacent normal tissues from three subjects were obtained. Differentially expressed genes (DEGs) and differentially expressed miRNAs were identified in HPSCC. Functional annotation and protein‑protein interaction (PPI) network were conducted to elucidate the biological functions of DEGs...
June 19, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29807145/raloxifene-a-promising-estrogen-replacement-limits-tdp-25-cell-death-by-enhancing-autophagy-and-suppressing-apoptosis
#2
Fuling Zhou, Hui Dong, Yaling Liu, Lina Yan, Can Sun, Pengli Hao, Yuanyuan Liu, Jingxu Zhai, Yakun Liu
Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disease, and at present, therapies for ALS are limited. Estrogen is a potential therapeutic agent for ALS but has undesirable effects that might increase the risk of breast and uterine cancers or stroke. Raloxifene (Ral) has estrogenic properties but does not exhibit these adverse effects. However, the mechanism of Ral in ALS has not been studied. We thus investigated the effects of Ral in an NSC34 model of ALS that stably expresses the 25-kDa C-terminal fragment of TDP-43 (i...
May 25, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29788280/genetic-and-environmental-factors-affecting-birth-size-variation-a-pooled-individual-based-analysis-of-secular-trends-and-global-geographical-differences-using-26-twin-cohorts
#3
Yoshie Yokoyama, Aline Jelenkovic, Yoon-Mi Hur, Reijo Sund, Corrado Fagnani, Maria A Stazi, Sonia Brescianini, Fuling Ji, Feng Ning, Zengchang Pang, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Esther Rebato, John L Hopper, Tessa L Cutler, Kimberly J Saudino, Tracy L Nelson, Keith E Whitfield, Robin P Corley, Brooke M Huibregtse, Catherine A Derom, Robert F Vlietinck, Ruth J F Loos, Clare H Llewellyn, Abigail Fisher, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Robert F Krueger, Matt McGue, Shandell Pahlen, Meike Bartels, Catharina E M van Beijsterveldt, Gonneke Willemsen, Jennifer R Harris, Ingunn Brandt, Thomas S Nilsen, Jeffrey M Craig, Richard Saffery, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Claire M A Haworth, Robert Plomin, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Finn Rasmussen, Per Tynelius, Adam D Tarnoki, David L Tarnoki, Syuichi Ooki, Richard J Rose, Kirsi H Pietiläinen, Thorkild I A Sørensen, Dorret I Boomsma, Jaakko Kaprio, Karri Silventoinen
Background: The genetic architecture of birth size may differ geographically and over time. We examined differences in the genetic and environmental contributions to birthweight, length and ponderal index (PI) across geographical-cultural regions (Europe, North America and Australia, and East Asia) and across birth cohorts, and how gestational age modifies these effects. Methods: Data from 26 twin cohorts in 16 countries including 57 613 monozygotic and dizygotic twin pairs were pooled...
May 19, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29770167/reactive-oxygen-species-mediated-tumor-microenvironment-transformation-the-mechanism-of-radioresistant-gastric-cancer
#4
REVIEW
Huifeng Gu, Tianhe Huang, Yicheng Shen, Yin Liu, Fuling Zhou, Yanxia Jin, Haseeb Sattar, Yongchang Wei
Radioresistance is one of the primary causes responsible for therapeutic failure and recurrence of cancer. It is well documented that reactive oxygen species (ROS) contribute to the initiation and development of gastric cancer (GC), and the levels of ROS are significantly increased in patients with GC accompanied with abnormal expressions of multiple inflammatory factors. It is also well documented that ROS can activate cancer cells and inflammatory cells, stimulating the release of a variety of inflammatory cytokines, which subsequently mediates the tumor microenvironment (TME) and promotes cancer stem cell (CSC) maintenance as well as renewal and epithelial-mesenchymal transition (EMT), ultimately resulting in radioresistance and recurrence of GC...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29763941/comprehensive-surgical-strategies-for-the-management-of-pachydermoperiostosis
#5
Du Taichao, Luo Fuling, Zhao Hengguang
The cosmetic and functional deformities induced by thickened folds and furrows are the main complaints of patients in pachydermoperiostosis (PDP). However, traditional drug therapy only has a limited effect for its unclear genetic pathogenesis. Surgical treatment has now become one of the optimal strategies mainly aiming for its cosmetic improvement. Here we describe a comprehensive management of PDP approached with surgical procedure thereby showing markedly improved cosmetic outcome. Experientially, the surgical treatment of PDP is effective and may be preferentially recommended for PDP patients especially of severe degree...
May 15, 2018: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/29733502/natural-killer-cell-immunotherapy-against-multiple-myeloma-progress-and-possibilities
#6
REVIEW
Pan Liu, Yanxia Jin, Haseeb Sattar, Hailing Liu, Weiling Xie, Fuling Zhou
Multiple myeloma (MM) is a complex aggressive mature B-cell malignancy. Although with the wide application of chemotherapy drugs, it remains incurable and the vast majority of patients relapse. Natural killer (NK) cells, also known as CD56+ CD3- large granular lymphocytes, are cytotoxic innate immune cells against MM without prior sensitization steps. NK cell-based immunotherapy is extensively promising in a wide range of clinical settings. It is worthy of note that some novel drugs such as monoclonal antibodies (mAbs), proteasome inhibitors (PIs), and immunomodulators (IMiDs) directly or indirectly activate NK cells to enhance their antitumor activity, and the combined regimens significantly improve the prognosis of MM patients...
May 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29706084/increased-peripheral-blood-visfatin-concentrations-may-be-a-risk-marker-of-coronary-artery-disease-a-meta-analysis-of-observational-studies
#7
Fuling Yu, Jianwei Li, Qilei Huang, Hongbin Cai
A comprehensive quantitative evaluation of the relationship between peripheral blood visfatin concentrations and coronary artery disease (CAD) is lacking. This study is the first attempt to quantify this relationship via a meta-analysis of published observational studies in terms of weighted mean difference (WMD). Literature retrieval, article selection, and data extraction were conducted. Heterogeneity was inspected using both subgroup and meta-regression analyses. In total, 15 articles involving 1053 CAD cases and 714 controls were included...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29703331/an-uplc-ms-ms-method-for-simultaneous-determination-of-multiple-constituents-in-guizhi-fuling-capsule-with-ultrafast-positive-negative-ionization-switching
#8
Rong-Hua Zhang, Chao-Ran Li, Hua Yang, Meng-Ning Li, Karl W K Tsim, Ping Li, Wen Gao
Guizhi Fuling capsule (GFC), a traditional Chinese medicine (TCM) with effects of promoting blood circulation and dissipating blood stasis, has been widely used in the clinic. Because of the complex matrix and various chemical structure types, quality control of GFC remains great challenge. In the present study, an ultra performance liquid chromatography hybrid triple-quadrupole mass spectrometry (UPLC-QQQ MS) method with ultrafast positive/negative ionization switching was developed for simultaneous determination of 18 bioactive components in GFC, including methyl gallate, ethyl gallate, oxypaeoniflorin, benzoic acid, albiflorin, paeonolide, paeoniflorin, 1, 2, 3, 4, 6-pentagalloylglucose, mudanpioside C, benzoyloxypaeoniflorin, benzoylpaeoniflorin, pachymic acid, amygdalin, cinnamaldehyde, paeonol, cinnamic acid, 4-hydroxybenzoic acid, and gallic acid...
April 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29676138/-clinical-experience-and-academic-thoughts-of-professor-liu-feng-bin-on-case-series-of-gastroesophageal-reflux-disease-based-on-data-mining
#9
Zheng-Kun Hou, Ji-Ping Li, Zhuo-Qun Chen, Feng-Bin Liu
To analyze and summarize Professor LIU Feng-bin's clinical experience and academic thoughts on gastroesophageal reflux disease (GERD), the study group adopted the retrospective study for case series and expert interview, extracted the retrospective data, including the herbs, diseases, syndrome type, medical expense and quantity of herbs of GERD patients attended the First Affiliated Hospital of Guangzhou University of Chinese Medicine. Statistical description and binary Logistic regression were used for the identification and modification of syndrome type and initial core herbs...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29674730/birth-size-and-gestational-age-in-opposite-sex-twins-as-compared-to-same-sex-twins-an-individual-based-pooled-analysis-of-21-cohorts
#10
Aline Jelenkovic, Reijo Sund, Yoshie Yokoyama, Yoon-Mi Hur, Vilhelmina Ullemar, Catarina Almqvist, Patrik Ke Magnusson, Gonneke Willemsen, Meike Bartels, Catharina Em van Beijsterveldt, Leonie H Bogl, Kirsi H Pietiläinen, Eero Vuoksimaa, Fuling Ji, Feng Ning, Zengchang Pang, Tracy L Nelson, Keith E Whitfield, Esther Rebato, Clare H Llewellyn, Abigail Fisher, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Adam D Tarnoki, David L Tarnoki, Syuichi Ooki, Maria A Stazi, Corrado Fagnani, Sonia Brescianini, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Tessa L Cutler, John L Hopper, Robert F Krueger, Matt McGue, Shandell Pahlen, Jeffrey M Craig, Richard Saffery, Claire Ma Haworth, Robert Plomin, Ariel Knafo-Noam, David Mankuta, Lior Abramson, S Alexandra Burt, Kelly L Klump, Robert F Vlietinck, Catherine A Derom, Ruth Jf Loos, Dorret I Boomsma, Thorkild I A Sørensen, Jaakko Kaprio, Karri Silventoinen
It is well established that boys are born heavier and longer than girls, but it remains unclear whether birth size in twins is affected by the sex of their co-twin. We conducted an individual-based pooled analysis of 21 twin cohorts in 15 countries derived from the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), including 67,850 dizygotic twin individuals. Linear regression analyses showed that boys having a co-twin sister were, on average, 31 g (95% CI 18 to 45) heavier and 0...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29656171/associations-between-birth-size-and-later-height-from-infancy-through-adulthood-an-individual-based-pooled-analysis-of-28-twin-cohorts-participating-in-the-codatwins-project
#11
Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Yoon-Mi Hur, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Syuichi Ooki, Vilhelmina Ullemar, Catarina Almqvist, Patrik K E Magnusson, Kimberly J Saudino, Maria A Stazi, Corrado Fagnani, Sonia Brescianini, Tracy L Nelson, Keith E Whitfield, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Tessa L Cutler, John L Hopper, Clare H Llewellyn, Abigail Fisher, Robin P Corley, Brooke M Huibregtse, Catherine A Derom, Robert F Vlietinck, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Robert F Krueger, Matt McGue, Shandell Pahlen, S Alexandra Burt, Kelly L Klump, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Gonneke Willemsen, Meike Bartels, Catharina E M van Beijsterveld, Jeffrey M Craig, Richard Saffery, Finn Rasmussen, Per Tynelius, Kauko Heikkilä, Kirsi H Pietiläinen, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Claire M A Haworth, Robert Plomin, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Adam D Tarnoki, David L Tarnoki, Jina Kim, Jooyeon Lee, Sooji Lee, Joohon Sung, Ruth J F Loos, Dorret I Boomsma, Thorkild I A Sørensen, Jaakko Kaprio, Karri Silventoinen
BACKGROUND: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. AIM: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. METHODS: This study is based on the data from 28 twin cohorts in 17 countries...
May 2018: Early Human Development
https://www.readbyqxmd.com/read/29600661/-post-marketing-surveillance-on-guizhi-fuling-jiaonang-based-on-literature-review
#12
Gui-Qian Wang, Yang Gao, Fu-Mei Liu, Rui-Li Wei, Yan-Ming Xie
To systemically evaluate the post-marketing safety of Guizhi Fuling Jiaonang. Computer retrieval was conducted in Medline, EMbase, the Web of Science, Clinical Trials. Gov, the Cochrane Library, CNKI, VIP, WanFang Data and CBM to collect relevant information. The papers were then screened according to inclusion and exclusion criteria. A total of 234 papers were included in this study, including 164 randomized controlled trials, 7 quasi-randomized controlled trials, 8 non-randomized controls, 56 case series, and 1 cohort study...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29535627/jab1-cops5-as-a-novel-biomarker-for-diagnosis-prognosis-therapy-prediction-and-therapeutic-tools-for-human-cancer
#13
REVIEW
Guohong Liu, Francois X Claret, Fuling Zhou, Yunbao Pan
C-Jun activation domain-binding protein-1 (Jab1) involves in controlling cellular proliferation, cell cycle, apoptosis, affecting a series of pathways, as well as regulating genomic instability and DNA damage response (DDR). Jab1/COPS5 dysregulation contributes to oncogenesis by deactivating several tumor suppressors and activating oncogenes. Jab1 overexpression was found in many tumor types, illuminating its important role in cancer initiation, progression, and prognosis. Jab1/COPS5 has spurred a strong research interest in developing inhibitors of oncogenes/oncoproteins for cancer therapy...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29479015/circadian-blood-pressure-variations-in-postmenopausal-females-with-hypertension
#14
Dan Su, Anqi Song, Bin Yan, Qi Guo, Ya Gao, Yanhua Zhou, Fuling Zhou, Guang Yang, Chaoying Zhang
The abnormalities of blood pressure (BP) nocturnal decline have been found to be predictive for carotid plaque and lacunar infarction in patients with hypertension. In this study, BP dipping patterns in postmenopausal females with hypertension were investigated. The nocturnal decline of systolic BP (SBP) was evaluated using 24-hour ambulatory BP monitoring (ABPM). A total of 163 postmenopausal females were eventually included in our study. The prevalence of reverse-dipper BP pattern was 32.3% in females with menopause age in their 40s and 40% in their 50s...
March 30, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29434881/-18-f-fluorodeoxyglucose-positron-emission-computed-tomography-for-monitoring-tumor-response-in-esophageal-carcinoma-treated-with-concurrent-chemoradiotherapy
#15
Peiliang Zhang, Zengyun Li, Dongqing Wang, Fuling Ma, Ran Zhang, Wanhua Liang, Mingping Sun, Zheng Fu, Xiaorong Sun
The aim of the present study was to explore the value of 18F- fluorodeoxyglucose positron emission tomography (18 F-FDG PET) in monitoring the early tumor response of esophageal squamous cell carcinoma (ESCC) treated with concurrent chemoradiotherapy (CRT). A total of 48 patients with pathologically proven ESCC were retrospectively analyzed. All patients underwent two serial 18 F-FDG PET scans at baseline (pre-CRT) and 40 Gy/4 weeks of starting radiation therapy (inter-CRT). All patients received intensity-modulated radiotherapy (with a total radiation dose of 59...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29357857/the-genotoxicity-of-an-aqueous-extract-of-gyejibokryeong-hwan
#16
Mee-Young Lee, Chang-Seob Seo, Hyekyung Ha, Eunsook Park, Ji-Young Kim, Hyeun-Kyoo Shin
BACKGROUND: Gyejibokryeong-hwan (Guizhi Fuling Wan in China), a mixture of five herbal plants, is a well-known treatment for renal diseases including those associated with climacteric syndrome. However, the genotoxicity of Gyejibokryeong-hwan has not yet been well established. METHODS: The present study investigated that the genotoxicity of an aqueous extract of Gyejibokryeong-hwan (GJBRHE): an in vitro chromosomal aberration test using Chinese hamster lung cells, an in vitro bacterial reverse mutation assay (Ames test) with Salmonella typhimurium and Escherichia coli strains, and an in vivo micronucleus test using ICR mouse bone marrow...
January 22, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29351213/cyclin-b3-deficiency-impairs-germline-stem-cell-maintenance-and-its-overexpression-delays-cystoblast-differentiation-in-drosophila-ovary
#17
Dongsheng Chen, Lijuan Zhou, Fuling Sun, Mingzhong Sun, Xiaoqian Tao
It is well known that cyclin B3 ( cycB3 ) plays a key role in the control of cell cycle progression. However, whether cycB3 is involved in stem cell fate determination remains unknown. The Drosophila ovary provides an exclusive model for studying the intrinsic and extrinsic factors that modulate the fate of germline stem cells (GSCs). Here, using this model, we show that Drosophila cycB3 plays a new role in controlling the fate of germline stem cells (GSC). Results from cycB3 genetic analyses demonstrate that cycB3 is intrinsically required for GSC maintenance...
January 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29321527/a-hospital-based-retrospective-study-of-factors-influencing-therapeutic-leukapheresis-in-patients-presenting-with-hyperleukocytic-leukaemia
#18
Yanxia Jin, Shishang Guo, Qin Cui, Sichao Chen, Xiaoping Liu, Yongchang Wei, Yunbao Pan, Liang Tang, Tingting Huang, Hui Shen, Guanghui Xu, Xuelan Zuo, Shangqin Liu, Hui Xiao, Fei Chen, Fayun Gong, Fuling Zhou
Therapeutic leukapheresis is a rapid and effective method to reduce early mortality of patients with hyperleukocytic leukaemia (HLL). However, few studies on factors influencing the efficiency have been reported. In this study, 67 cases who underwent leukapheresis were retrospectively analysed and factors related to the collection efficiency of leukapheresis (CEWBC ) were also evaluated. Paired t test showed that there was a significant decrease in statistics of white blood cell (WBC) counts after apheresis...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29299236/the-effects-of-elevated-co-2-0-5-on-chloroplasts-in-the-tetraploid-black-locust-robinia-pseudoacacia-l
#19
Yuan Cao, Mingquan Jiang, Fuling Xu, Shuo Liu, Fanjuan Meng
Some ploidy plants demonstrate environmental stress tolerance. Tetraploid (4×) black locust ( Robinia pseudoacacia L.) exhibits less chlorosis in response to high CO2 than do the corresponding diploid (2×) plants of this species. We investigated the plant growth, anatomy, photosynthetic ability, chlorophyll (chl) fluorescence, and antioxidase activities in 2× and 4× black locusts cultivated under high CO2 (0.5%). Elevated CO2 (0.5%) induced a global decrease in the contents of total chl, chl a, and chl b in 2× leaves, while few changes were found in the chl content of 4× leaves...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29240175/radiation-induced-birefringence-variations-in-polarization-maintaining-fibers
#20
Yuanhong Yang, Hui Li, Lin Lu, Fuling Yang, Wei Jin
Gamma radiation-induced birefringence (RIB) variations in a solid core photonic crystal polarization-maintaining fiber (Pc-PMF) and a Panda PMF (Pa-PMF) are investigated. Experiments show that the birefringence of the fibers changes approximately linearly with a radiation dose over the range from 0 to 400 krad(Si), with negative slope coefficients of 8.91×10-10 /krad(Si) and 4.38×10-9 /krad(Si) for the Pc-PMF and Pa-PMF, respectively. Models of RIB variations for the two fibers are established, and the theoretical results agree well with the experimental ones...
December 15, 2017: Optics Letters
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