James R Birtley, Mohammad Alomary, Elisa Zanini, Jane Antony, Zachary Maben, Grant C Weaver, Claudia Von Arx, Manuela Mura, Aline T Marinho, Haonan Lu, Eloise V N Morecroft, Evdoxia Karali, Naomi E Chayen, Edward W Tate, Mollie Jurewicz, Lawrence J Stern, Chiara Recchi, Hani Gabra
OPCML, a tumor suppressor gene, is frequently silenced epigenetically in ovarian and other cancers. Here we report, by analysis of databases of tumor sequences, the observation of OPCML somatic missense mutations from various tumor types and the impact of these mutations on OPCML function, by solving the X-ray crystal structure of this glycoprotein to 2.65 Å resolution. OPCML consists of an extended arrangement of three immunoglobulin-like domains and homodimerizes via a network of contacts between membrane-distal domains...
July 17, 2019: Nature Communications