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https://www.readbyqxmd.com/read/29774551/in-vitro-hemodynamic-evaluation-of-an-adult-pulsatile-extracorporeal-membrane-oxygenation-system
#1
Shigang Wang, Morgan Moroi, Christoph E Brehm, Allen R Kunselman, Akif Ündar
The objective of this study was to evaluate a pulsatile extracorporeal membrane oxygenation (ECMO) system in terms of hemodynamic energy generation and transmission under various pulsatile amplitudes, flow rates, and pseudopatient pressures in a simulated adult ECMO circuit. Surplus hemodynamic energy (SHE), a measure of the quality of pulsatility, was used to quantify pulsatile flow. The circuit consisted of an i-cor diagonal pump, an adult XLung oxygenator, a 21 Fr Medtronic Biomedicus femoral arterial cannula, a 23/25 Fr Sorin RAP femoral venous cannula, and 3/8 in ID tubing for both arterial and venous lines...
May 17, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29771243/breath-volatile-organic-compounds-of-lung-transplant-recipients-with-and-without-chronic-lung-allograft-dysfunction
#2
Lucas Küppers, Olaf Holz, Sven Schuchardt, Jens Gottlieb, Jan Fuge, Mark Greer, Jens Hohlfeld
Chronic lung allograft dysfunction (CLAD) with its clinical correlative of bronchiolitis obliterans syndrome (BOS) remains the major limiting factor for long-term graft survival. Currently there are no established methods for the early diagnosis or prediction of BOS. To assess the feasibility of breath collection as a non-invasive tool and the potential of breath volatile organic compounds (VOC) for the early detection of BOS, we compared the breath VOC composition between transplant patients without and different stages of BOS...
May 17, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29771120/effects-of-se-incorporation-in-la-5-ti-2-cus-5-o-7-by-annealing-on-physical-properties-and-photocatalytic-h-2-evolution-activity
#3
Swarnava Nandy, Takashi Hisatomi, Song Sun, Masao Katayama, Tsutomu Minegishi, Kazunari Domen
Oxysulfoselenide semiconductor photocatalysts absorb light at longer wavelengths than the corresponding oxysulfides. However, the synthesis of oxysulfoselenides is challenging due to excessive particle growth and the limited availability of metal selenide precursors. In this study, a La5 Ti2 CuS5 O7 (LTCSO) oxysulfide was annealed with Se powder in sealed, evacuated quartz tubes to obtain LTCSO:Se photocatalysts, and the properties of these materials were investigated. Se was found to be incorporated into the LTCSO upon heating at 973 K or higher, and the Se/(S + Se) ratio was increased to a maximum of 0...
May 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29760722/microrna-126-priming-enhances-functions-of-endothelial-progenitor-cells-under-physiological-and-hypoxic-conditions-and-their-therapeutic-efficacy-in-cerebral-ischemic-damage
#4
Qunwen Pan, Jieyi Zheng, Donghui Du, Xiaorong Liao, Chunlian Ma, Yi Yang, Yanyu Chen, Wangtao Zhong, Xiaotang Ma
Endothelial progenitor cells (EPCs) have shown the potential for treating ischemic stroke (IS), while microRNA-126 (miR-126) is reported to have beneficial effects on endothelial function and angiogenesis. In this study, we investigated the effects of miR-126 overexpression on EPCs and explore the efficacy of miR-126-primed EPCs (EPCmiR-126 ) in treating IS. The effects of miR-126 overexpression on EPC proliferation, migratory, tube formation capacity, reactive oxygen species (ROS) production, and nitric oxide (NO) generation were determined...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29757793/technique-utilizing-a-modified-oral-ring-adair-elwyn-tube-to-provide-continuous-oxygen-and-sevoflurane-delivery-during-nasotracheal-intubation-in-an-infant-with-a-difficult-airway-a-case-report
#5
Janice Y Man, John E Fiadjoe, Grace Hsu
Managing the airway of an infant with Pierre Robin sequence (PRS) is particularly challenging for anesthesiologists. Patients with PRS have the triad of micrognathia, glossoptosis, and airway obstruction that potentially and frequently leads to difficulty with both ventilation and intubation. Thus continuous oxygenation and spontaneous ventilation during intubation are essential. We describe a new method to deliver continuous oxygen and volatile anesthetic during nasotracheal intubation in an infant with PRS...
May 15, 2018: A&A practice
https://www.readbyqxmd.com/read/29756744/monitoring-the-oxygen-reserve-index-can-contribute-to-the-early-detection-of-deterioration-in-blood-oxygenation-during-one-lung-ventilation
#6
Wakana Koishi, Motoi Kumagai, Shohei Ogawa, Shuhei Hongo, Kenji Suzuki
BACKGROUND: Hypoxemia can occur during one-lung ventilation (OLV), but monitoring blood oxygenation using percutaneous oxygen saturation (SpO2) can be limited by detection latency, and SpO2 sometimes does not change during OLV. The Oxygen Reserve Index (ORiTM) is a novel index reported to detect impending desaturation before this is observed with SpO2 monitoring. This study assessed whether the ORi decreased earlier than SpO2 during OLV and evaluated its correlation with the partial pressure of arterial oxygen (PaO2) during OLV...
May 14, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29744656/pediatric-pulmonary-artery-rehabilitation-a-review-of-our-experience-and-a-novel-approach-using-bronchial-blockers
#7
Peter D Winch, Dmitry Tumin, Jeffrey Moore, Samantha J Vizzini, Darren P Berman, Aymen N Naguib
Recent advances in the field of pediatric interventional cardiology have resulted in therapies for patients in need of augmented pulmonary artery (PA) flow. Catheter-based PA rehabilitation can be performed safely but not without the potential risk of pulmonary hemorrhage. When severe, this bleeding has the ability to contaminate the bronchi and trachea, and possibly occlude the endotracheal tube. This can result in a critical inability to ventilate and oxygenate these patients. Herein, we review our institutional experience with pulmonary hemorrhage associated with these procedures and the feasibility of predicting this outcome...
May 9, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29741076/monitoring-of-hospital-acquired-pneumonia-in-patients-with-severe-brain-injury-on-first-access-to-intensive-neurological-rehabilitation-first-year-of-observation
#8
Gianfranco Beghi, Antonio De Tanti, Paolo Serafini, Chiara Bertolino, Antonietta Celentano, Graziella Taormina
Nosocomial or hospital acquired pneumonia (HAP) is an illness contracted during a hospital stay, generally with onset 48 hours or more after admission to hospital, or within 14 days of discharge from hospital. HAP is divided into subgroups: Ventilator-associated pneumonia (VAP), accounting for 86% of hospital acquired pneumonia, and stroke-associated pneumonia (SAP). The incidence of SAP in neurological intensive care units (NICUs) is 4.1-56.6%, in medical intensive care units (MICUs) it is 17-50%, in stroke units it is 3...
May 9, 2018: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/29739649/desaturation-times-between-dogs-preoxygenated-via-face-mask-or-flow-by-technique-before-induction-of-anesthesia
#9
Barbara Ambros, Maria Valentina Carrozzo, Teela Jones
OBJECTIVE: To compare time to desaturation after induction of anesthesia following administration of oxygen via face mask or flow-by for 3 minutes. STUDY DESIGN: Randomized crossover study. ANIMALS: A group of six healthy adult dogs weighing 15.0 ± 3.4 kg. METHODS: Dogs were anesthetized twice separated by 14 days. Intramuscular administration of dexmedetomidine (4 μg kg-1 ), acepromazine (0.01 mg kg-1 ) and butorphanol (0...
April 10, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29736769/world-health-organization-world-federation-of-societies-of-anaesthesiologists-who-wfsa-international-standards-for-a-safe-practice-of-anesthesia
#10
Adrian W Gelb, Wayne W Morriss, Walter Johnson, Alan F Merry
The International Standards for a Safe Practice of Anesthesia were developed on behalf of the World Federation of Societies of Anaesthesiologists (WFSA), a non-profit organization representing anesthesiologists in 150 countries, and the World Health Organization (WHO). The recommendations have been approved by WHO and the membership of WFSA. These Standards are applicable to all anesthesia providers throughout the world. They are intended to provide guidance and assistance to anesthesia providers, their professional organizations, hospital and facility administrators, and governments for maintaining and improving the quality and safety of anesthesia care...
May 7, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29734240/world-health-organization-world-federation-of-societies-of-anaesthesiologists-who-wfsa-international-standards-for-a-safe-practice-of-anesthesia
#11
Adrian W Gelb, Wayne W Morriss, Walter Johnson, Alan F Merry, Anuja Abayadeera, Natalia Belîi, Sorin J Brull, Aline Chibana, Faye Evans, Cyril Goddia, Carolina Haylock-Loor, Fauzia Khan, Sandra Leal, Nan Lin, Richard Merchant, Mark W Newton, Jackie S Rowles, Arinola Sanusi, Iain Wilson, Adriana Velazquez Berumen
The International Standards for a Safe Practice of Anesthesia were developed on behalf of the World Federation of Societies of Anaesthesiologists (WFSA), a nonprofit organization representing anesthesiologists in 150 countries, and the World Health Organization (WHO). The recommendations have been approved by WHO and the membership of WFSA. These Standards are applicable to all anesthesia providers throughout the world. They are intended to provide guidance and assistance to anesthesia providers, their professional organizations, hospital and facility administrators, and governments for maintaining and improving the quality and safety of anesthesia care...
June 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29729051/preliminary-assessment-of-stable-nitrogen-and-oxygen-isotopic-composition-of-usgs51-and-usgs52-nitrous-oxide-reference-gases-and-perspectives-on-calibration-needs
#12
Nathaniel E Ostrom, Hasand Gandhi, Tyler B Coplen, Sakae Toyoda, J K Böhlke, Willi A Brand, Karen L Casciotti, Jens Dyckmans, Anette Giesemann, Joachim Mohn, Reinhard Well, Longfei Yu, Naohiro Yoshida
RATIONALE: Despite a long history and growing interest in isotopic analyses of N2 O, there is a lack of isotopically characterized N2 O isotopic reference materials (standards) to enable normalization and reporting of isotope-delta values. Here we report the isotopic characterization of two pure N2 O gas reference materials, USGS51 and USGS52, which are now available for laboratory calibration (https://isotopes.usgs.gov/lab/referencematerials.html). METHODS: A total of 400 sealed borosilicate glass tubes of each N2 O reference gas were prepared from a single gas filling of a high vacuum line...
May 4, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29719126/randomized-controlled-trial-comparing-the-supraglottic-airway-to-use-of-an-endotracheal-tube-in-sinonasal-surgery
#13
Austin S Adams, Todd J Wannemuehler, Benjamin Hull, Jeffanie Wu, Rakesh K Chandra, Kate VonWahlde, Matthew S Shotwell, Stephen Harvey, Michael Higgins, Kelly McQueen, Justin H Turner
BACKGROUND: The supraglottic airway (SGA) represents an alternative to endotracheal intubation (endotracheal tube [ETT]) in many types of ambulatory surgery. Adoption of the SGA has progressed slowly in sinonasal surgery due to concerns about airway protection. The purpose of this study was to compare quality of life measures and indices of airway protection between patients undergoing sinonasal surgery who were ventilated via an SGA or ETT. METHODS: Patients undergoing outpatient sinonasal surgery were enrolled into a randomized, single-blind study in which patients would be ventilated with either an SGA or ETT...
May 2, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29717803/ultrathin-wall-1-nm-and-superlong-pt-nanotubes-with-enhanced-oxygen-reduction-reaction-performance
#14
Lu Tao, Dan Yu, Junshuang Zhou, Xiong Lu, Yunxia Yang, Faming Gao
The synthesis of Pt nanotubes catalysts remains a substantial challenge, especially for those with both sub-nanometer wall thickness and micrometer-scale length characteristics. Combining techniques of insulin fibril template with Pd nanowire template, numerous Pt nanotubes with diameter of 5.5 nm, tube-length of several micrometers, and ultrathin wall thickness of 1 nm are assembled. These tubular catalysts with both open ends deliver electrochemical active surface area (ECSA) of 91.43 m2 gpt -1 which results from multiple Pt atoms exposed on the inner and outer surfaces that doubled Pt atoms can participate in catalytic reactions, further with enhanced electrocatalytic performance for oxygen reduction reaction (ORR)...
May 2, 2018: Small
https://www.readbyqxmd.com/read/29705934/exosomes-secreted-by-adipose-derived-stem-cells-contribute-to-angiogenesis-of-brain-microvascular-endothelial-cells-following-oxygen-glucose-deprivation-in-vitro-through-microrna-181b-trpm7-axis
#15
Yujia Yang, Yue Cai, Yuan Zhang, Juan Liu, Zhiqiang Xu
Adipose-derived stem cells (ADSCs) have been demonstrated to promote cerebral vascular remodeling processes after stroke. However, the exact molecular mechanism by which ADSCs exert protective roles in ischemic stroke is still poorly understood. In this study, we identified the role of exosomal microRNA-181b-5p (181b-Exos) in regulating post-stroke angiogenesis. The results of migration assay and capillary network formation assay showed that exosomes secreted by ADSCs (ADSCs-Exos) promoted the mobility and angiogenesis of brain microvascular endothelial cells (BMECs) after oxygen-glucose deprivation (OGD)...
April 29, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29705216/effect-of-minimally-invasive-endotracheal-tube-suctioning-on-physiological-indices-in-adult-intubated-patients-an-open-labelled-randomised-controlled-trial
#16
Mahdi Shamali, Mohammad Abbasinia, Birte Østergaard, Hanne Konradsen
BACKGROUND: Endotracheal tube suctioning (ETS) is one of the most frequent procedures performed by nurses in intensive care units. Nevertheless, some suctioning practices are still being performed that do not provide any benefit for patients. OBJECTIVES: To investigate the effects of minimally invasive ETS (MIETS) versus routine ETS (RETS) on physiological indices in adult intubated patients. METHODS: In this single centre parallel randomised controlled, open label trial, 64 adult intubated patients in the four intensive care units of Alzahra University hospital, Isfahan, Iran, were randomly allocated to a MIETS or a RETS group...
April 25, 2018: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/29701760/optical-techniques-for-perfusion-monitoring-of-the-gastric-tube-after-esophagectomy-a-review-of-technologies-and-thresholds
#17
S M Jansen, D M de Bruin, M I van Berge Henegouwen, S D Strackee, D P Veelo, T G van Leeuwen, S S Gisbertz
Anastomotic leakage is one of the most severe complications after esophageal resection with gastric tube reconstruction. Impaired perfusion of the gastric fundus is seen as the main contributing factor for this complication. Optical modalities show potential in recognizing compromised perfusion in real time, when ischemia is still reversible. This review provides an overview of optical techniques with the aim to evaluate the (1) quantitative measurement of change in perfusion in gastric tube reconstruction and (2) to test which parameters are the most predictive for anastomotic leakage...
April 26, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29690632/ros-activated-ion-channels-in-plants-biophysical-characteristics-physiological-functions-and-molecular-nature
#18
REVIEW
Vadim Demidchik
Ion channels activated by reactive oxygen species (ROS) have been found in the plasma membrane of charophyte Nitella flixilis , dicotyledon Arabidopsis thaliana , Pyrus pyrifolia and Pisum sativum , and the monocotyledon Lilium longiflorum . Their activities have been reported in charophyte giant internodes, root trichoblasts and atrichoblasts, pollen tubes, and guard cells. Hydrogen peroxide and hydroxyl radicals are major activating species for these channels. Plant ROS-activated ion channels include inwardly-rectifying, outwardly-rectifying, and voltage-independent groups...
April 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29687856/granulocyte-colony-stimulating-factor-improves-neurological-function-and-angiogenesis-in-intracerebral-hemorrhage-rats
#19
S-D Liang, L-Q Ma, Z-Y Gao, Y-Y Zhuang, Y-Z Zhao
OBJECTIVE: Granulocyte colony-stimulating factor (G-CSF) plays a role in regulating phosphatidylinositol-3-kinase/serine/threonine kinase (PI3K/AKT) pathway, affecting cell proliferation and apoptosis, and inducing vascular endothelial growth factor (VEGF) expression. This study investigated the mechanism of G-CSF on angiogenesis and neural protection after intracerebral hemorrhage (ICH). MATERIALS AND METHODS: The rats were divided into four groups, including sham, ICH, ICH+G-CSF, and ICH+G-CSF+LY294002 (PI3K/AKT signaling pathway specific inhibitor)...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29686052/synthesis-of-human-neutrophil-extracellular-traps-contributes-to-angiopoietin-mediated-in-vitro-proinflammatory-and-proangiogenic-activities
#20
Simon S Lavoie, Elizabeth Dumas, Branka Vulesevic, Paul-Eduard Neagoe, Michel White, Martin G Sirois
Neutrophil extracellular traps (NETs) are composed of nuclear DNA in a web-like structure extruded from neutrophils in response to either bacterial infection or inflammation. We previously reported the expression of angiopoietin Tie2 receptor on human neutrophils and the capacity of both angiopoietins (Ang1 and Ang2) to induce proinflammatory activities, such as synthesis and release of platelet-activating factor, upregulation of β2 integrin complex (CD11/CD18), and neutrophil chemotaxis. In contrast, only Ang1 but not Ang2 is capable of promoting translational and transcriptional activities in neutrophils...
April 23, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
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