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https://www.readbyqxmd.com/read/28074798/proseal-laryngeal-mask-airway-as-an-alternative-to-standard-endotracheal-tube-in-securing-upper-airway-in-the-patients-undergoing-beating-heart-coronary-artery-bypass-grafting
#1
Kalpana Shah
BACKGROUND: ProSeal laryngeal mask airways (PLMAs) are routinely used after failed tracheal intubation as airway rescue, facilitating tracheal intubation by acting as a conduit and to secure airway during emergencies. In long duration surgeries, use of endotracheal tube (ETT) is associated with various hemodynamic complications, which are minimally affected during PLMA use. However, except for few studies, there are no significant data available that promote the use of laryngeal mask during cardiac surgery...
January 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28067317/glucose-6-phosphate-isomerase-g6pi-mediates-hypoxia-induced-angiogenesis-in-rheumatoid-arthritis
#2
Ying Lu, Shan-Shan Yu, Ming Zong, Sha-Sha Fan, Tian-Bao Lu, Ru-Han Gong, Li-Shan Sun, Lie-Ying Fan
The higher level of Glucose-6-phosphate isomerase (G6PI) has been found in both synovial tissue and synovial fluid of rheumatoid arthritis (RA) patients, while the function of G6PI in RA remains unclear. Herein we found the enrichment of G6PI in microvascular endothelial cells of synovial tissue in RA patients, where a 3% O2 hypoxia environment has been identified. In order to determine the correlation between the high G6PI level and the low oxygen concentration in RA, a hypoxia condition (~3% O2) in vitro was applied to mimic the RA environment in vivo...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28058435/direct-thermolysis-of-co2-into-co-and-o2
#3
Qingqing Jiang, Zhenpan Chen, Jinhui Tong, Min Yang, Zongxuan Jiang, Can Li
Most of the solar-driven thermochemical CO2 dissociation reactions have been focused on two-step processes. In this study, a one step CO2 thermolysis process was considered. It was found that direct thermolysis of CO2 obviously occurred at temperatures as low as 1200 °C within a corundum tube. The reaction rate could be enhanced by several times in the presence of metal oxides, which may be attributed to the catalysis of oxygen vacancies in the metal oxides.
January 6, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28054715/tubal-origin-of-ovarian-cancer-the-double-edged-sword-of-haemoglobin
#4
Shiou-Fu Lin, Emily Gerry, Ie-Ming Shih
Ovarian high-grade serous carcinoma (HGSC) is the most malignant neoplasm of the gynaecologic tract. While the origins of many human malignant neoplasms are clear, the origin of HGSC remains poorly understood. This lack of knowledge limits our understanding of its pathogenesis and compromises efforts devoted to develop better early detection tools and effective preventative intervention. The tubal origin of HGSC has been put forward since the initial report of dysplastic lesions (now known as serous tubal intraepithelial carcinomas, or STICs) that morphologically resemble HGSC in the fallopian tube...
January 5, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28054235/heated-humidified-high-flow-nasal-cannula-for-prevention-of-extubation-failure-in-preterm-infants
#5
Sasivimon Soonsawad, Buranee Swatesutipun, Anchalee Limrungsikul, Pracha Nuntnarumit
OBJECTIVES: To compare extubation failure rate between the heated humidified high-flow nasal cannula (HHHFNC) and continuous positive airway pressure (CPAP) groups. METHODS: Intubated infants with gestational age (GA) <32 wk, who were ready to extubate, were randomized to receive respiratory support with either CPAP or HHHFNC after extubation. In CPAP group, nasal mask CPAP with preset pressure and fraction of inspired oxygen (FiO2) equal to positive end-expiratory pressure (PEEP) and FiO2 of ventilator before extubation was applied...
January 5, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28052587/pilot-study-of-dornase-alfa-pulmozyme-therapy-for-acquired-ventilator-associated-infection-in-preterm-infants
#6
Melissa Scala, Deborah Hoy, Maria Bautista, Judith Jones Palafoutas, Kabir Abubakar
OBJECTIVE: Evaluate the feasibility, safety, and efficacy of adjunctive treatment with dornase alfa in preterm patients with ventilator-associated pulmonary infection (VAPI) compared to standard care. WORKING HYPOTHESIS: We hypothesize that therapy with dornase alfa will be safe and well tolerated in the preterm population with no worsening of symptoms, oxygen requirement, or need for respiratory support. STUDY DESIGN: Prospective, randomized, blinded, pilot study comparing adjunctive treatment with dornase alfa to sham therapy...
January 3, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28046474/th-ab-209-04-3d-light-sheet-luminescence-imaging-with-cherenkov-radiation
#7
P Bruza, H Lin, L Jarvis, D Gladstone, B Pogue
PURPOSE: To recover a three-dimensional density distribution of luminescent molecular probes located several centimeters deep within a highly scattering tissue. METHODS: We developed a novel sheet beam Cherenkov-excited luminescence scanned imaging (CELSI) methodology. The sample was irradiated by a horizontally oriented, vertically scanned 6 MV X-ray sheet beam (200mm × 5mm, 0.2mm vertical step) from a radiotherapy linear accelerator. The resulting Cherenkov light emission - and thus luminescent probe excitation - occurred exclusively along the irradiation plane due to a short diffusion path of secondary particles and Cherenkov photons...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040799/chloride-essential-micronutrient-and-multifunctional-beneficial-ion
#8
John A Raven
Cl(-) is an essential micronutrient for oxygenic photolithotrophs. About half of global primary productivity is carried out by oxygenic photolithotrophs exposed to saline waters with Cl(-) concentrations orders of magnitude higher than that needed to satisfy the micronutrient requirement. The other half of primary productivity involves terrestrial and freshwater glycophytes sometimes in environments containing significantly more Cl(-) than is needed for the micronutrient requirement, but less than the toxic Cl(-) concentration for glycophytes...
December 30, 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28033257/incidental-left-main-bronchus-obstruction-during-left-sided-double-lumen-tube-intubation-of-a-patient-with-an-unrecognized-tracheal-bronchus-a-case-report
#9
Ho Bum Cho, Hyoung June Kim, Hyung Youn Gong, Mun Gyu Kim, Sang Ho Kim
INTRODUCTION: Tracheal bronchus is a right-sided anomalous bronchus arising from the trachea above the main carina and occurs in 0.1% to 2% of the general population. CASE PRESENTATION: We present a case of left main bronchus obstruction during a left-sided double-lumen tube intubation in a patient with an unrecognized tracheal bronchus. After the intubation, to confirm the position of the tube, we observed what we believed was the carina with a fiberoptic bronchoscope, but it was a site between the tracheal bronchus and the right main bronchus...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28033162/an-ex-vivo-model-to-decipher-the-impact-of-extracorporeal-membrane-oxygenation-on-beta-lactam-degradation-kinetics
#10
Cyril Leven, Pierre Fillâtre, Antoine Petitcollin, Marie-Clémence Verdier, Jérôme Laurent, Nicolas Nesseler, Yoann Launey, Pierre Tattevin, Eric Bellissant, Erwan Flécher, Florian Lemaitre
BACKGROUND: As a consequence of drug sequestration, increase in volume of distribution or alteration of elimination, extracorporeal membrane oxygenation (ECMO) might lead to inadequate plasma concentrations of vital drugs. The aim of this experimental study was to develop an ex vivo model to better characterize the impact of ECMO procedure on beta-lactam antibiotics pharmacokinetics. METHODS: Plasma concentrations of cefotaxime, ceftazidime, cefepime, piperacillin, oxacillin, amoxicillin, and ceftriaxone were measured in an ex vivo ECMO circuit primed with whole human blood and compared to controls stored in glass tubes and polyvinyl chloride (PVC) tubing...
December 23, 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28011628/a-genetically-encoded-biosensor-for-visualizing-hypoxia-responses-in-vivo
#11
Tvisha Misra, Martin Baccino-Calace, Felix Meyenhofer, David Rodriguez-Crespo, Hatice Akarsu, Ricardo Armenta-Calderón, Thomas A Gorr, Christian Frei, Rafael Cantera, Boris Egger, Stefan Luschnig
Cells experience different oxygen concentrations depending on location, organismal developmental stage, and physiological or pathological conditions. Responses to reduced oxygen levels (hypoxia) rely on the conserved Hypoxia-Inducible Factor 1 (HIF-1). Understanding the developmental and tissue-specific responses to changing oxygen levels has been limited by the lack of adequate tools for monitoring HIF-1 in vivo. To visualise and analyse HIF-1 dynamics in Drosophila, we used a hypoxia biosensor consisting of GFP fused to the oxygen-dependent degradation domain (ODD) of the HIF-1 homologue Sima...
December 23, 2016: Biology Open
https://www.readbyqxmd.com/read/28003555/redesign-of-an-open-system-oxygen-face-mask-with-mainstream-capnometer-for-children
#12
Natalie Napolitano, Akira Nishisaki, Hayley S Buffman, Jessica Leffelman, Matthew R Maltese, Vinay M Nadkarni
BACKGROUND: Partial pressure of end-tidal carbon dioxide (PETCO2 ) monitoring in children is important to detect apnea or hypopnea early to intervene before hypoxemia develops. Monitoring PETCO2 in children without a tracheal tube is challenging. To improve PETCO2 measurement accuracy in a commercially available mask with a mainstream CO2 detector, we implemented design changes with deform-and-hold shaping technology and anterior-posterior adjustment of the expiratory gas flow cup. METHODS: Two sizes of redesigned face masks (small for 7-20 kg, medium for 10-40 kg) were evaluated...
January 2017: Respiratory Care
https://www.readbyqxmd.com/read/27998860/-anesthetic-effect-and-safety-of-ultrasound-guided-thoracic-paravertebral-blockade-in-sympathectomy-for-palmar-hyperhidrosis-a-randomized-controlled-trial
#13
Jin-Dong Xu, Li-Na Yu, Da-Qiang Zhao, Liang Xie, Hai-Yu Zhou, Sheng Wang
OBJECTIVE: To explore the anesthetic effect and safety of ultrasound-guided thoracic paravertebral blockade in video-assisted thoracoscopic sympathectomy for treatment of palmar hyperhidrosis. METHODS: A total of 120 patients undergoing video-assisted thoracoscopic sympathectomy for moderate or severe hyperhidrosis were randomized to receive ultrasound-guided thoracic paravertebral blockade (group A, n=60) or general anesthesia with tracheal intubation (group B, n=60)...
December 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27994436/role-of-endogenous-insulin-gene-enhancer-protein-isl-1-in-angiogenesis
#14
Si-Qi Xiong, Hai-Bo Jiang, Yan-Xiu Li, Hai-Bo Li, Hui-Zhuo Xu, Zhen-Kai Wu, Wei Zheng, Xiao-Bo Xia
OBJECTIVE: To elucidate the role of insulin gene enhancer protein ISL-1 (Islet-1) in angiogenesis and regulation of vascular endothelial growth factor (VEGF) expression in vitro and in vivo. METHODS: siRNA targeting Islet-1 was transfected to human umbilical vein endothelial cell lines (HUVECs). The expression of Islet-1 and VEGF in the cultured cells was measured using real-time PCR and immunoblotting. 3-[4,5-dimethylthiazol-2-yl]-2,5- diphenyltetrazolium bromide; thiazolyl blue (MTT) assay was used to analyze the proliferation of HUVECs affected by Islet-1...
2016: Molecular Vision
https://www.readbyqxmd.com/read/27990031/grain-size-and-grain-depth-restrict-oxygen-movement-in-leaky-hermetic-containers-and-contribute-to-protective-effect
#15
Scott B Williams, Larry L Murdock, Kabita Kharel, Dieudonne Baributsa
Postharvest insect pests threaten the nutritional and financial security of smallholder farmers in the developing world. Hermetic storage, a technology that protects grain against insects by blocking their supply of oxygen, alleviates the problem of insect-caused losses. PICS (Purdue Improved Crop Storage) bags represent one hermetic technology that improves food availability and incomes of farmers. The polyethylene liners of PICS bags are sometime damaged during use, acquiring small holes or tears. Observations in the laboratory and field suggest that insect development remains localized around the point where the bag is damaged...
October 2016: Journal of Stored Products Research
https://www.readbyqxmd.com/read/27976361/early-nasal-intermittent-positive-pressure-ventilation-nippv-versus-early-nasal-continuous-positive-airway-pressure-ncpap-for-preterm-infants
#16
REVIEW
Brigitte Lemyre, Matthew Laughon, Carl Bose, Peter G Davis
BACKGROUND: Nasal continuous positive airway pressure (NCPAP) is a strategy for maintaining positive airway pressure throughout the respiratory cycle through the application of bias flow of respiratory gas to an apparatus attached to the nose. Treatment with NCPAP is associated with decreased risk of mechanical ventilation and might be effective in reducing chronic lung disease. Nasal intermittent positive pressure ventilation (NIPPV) is a form of noninvasive ventilation during which patients are exposed intermittently to higher levels of airway pressure, along with NCPAP through the same nasal device...
December 15, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27942052/critical-incidents-in-paediatric-anaesthesia-a-prospective-analysis-over-a-1-year-period
#17
Raylene Dias, Nandini Dave, Swapna Chiluveru, Madhu Garasia
BACKGROUND AND AIMS: Critical incident reporting helps to identify errors and formulate preventive strategies. Many countries have existing national reporting systems. Such a system is yet to be established in India. We aimed to study the incidence of critical events in the paediatric operation theatre (OT) of our institute. METHODS: We conducted a prospective observational study of all children receiving anaesthesia in paediatric OT over a period of 1 year. They were monitored intraoperatively as well as postoperatively, and critical incidents were noted in terms of date and time of incident, location (OT/post-anaesthesia care unit, clinical category, age of patient, degree of patient harm resulting from the incident, description of what happened and duration of surgery...
November 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/27938475/imbalanced-production-of-reactive-oxygen-species-and-mitochondrial-antioxidant-sod2-in-fabry-disease-specific-human-induced-pluripotent-stem-cell-differentiated-vascular-endothelial-cells
#18
Wei-Lien Tseng, Shih-Jie Chou, Huai-Chih Chiang, Mong-Lien Wang, Chian-Shiu Chien, Kuan-Hsuan Chen, Hsin-Bang Leu, Chien-Ying Wang, Yuh-Lih Chang, Yung-Yang Liu, Yuh-Jyh Jong, Shing-Jong Lin, Shih-Hwa Chiou, Wen-Chung Yu, Shinn-Zong Lin
Fabry disease (FD) is an X-linked inherited lysosomal storage disease caused by α-galactosidase A (GLA) deficiency. Progressive intracellular accumulation of globotriaosylceramide (Gb3) is considered to be pathogenically responsible for the phenotype variability of FD that causes cardiovascular dysfunction; however, molecular mechanisms underlying the impairment of FD-associated cardiovascular tissues remain unclear. In this study, we reprogrammed human induced pluripotent stem cells (hiPSC) from peripheral blood cells of patients with FD (FD-iPSCs); subsequently differentiated them into vascular endothelial-like cells (FD-ECs) expressing CD31, VE-cadherin, and vWF; and investigated their ability to form vascular tube-like structures...
6, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27935152/intellectual-outcomes-of-extremely-preterm-infants-at-school-age
#19
Maya Asami, Atsushi Kamei, Misato Nakakarumai, Satoko Shirasawa, Manami Akasaka, Nami Araya, Sachiko Tanifuji, Shoichi Chida
BACKGROUND: The survival rate of extremely preterm (EP) infants (<28 weeks of gestation) has improved dramatically, and there is great interest in their long-term prognoses. This study aims to elucidate the influence of prenatal and postnatal care on long-term intellectual outcomes in EP infants. METHODS: Subjects were EP infants who were admitted to our neonatal intensive care unit from 1982 to 2005. The survival rate and neurodevelopmental outcomes at 6 years of age were analyzed for the periods of 1982-1991 (period 1) and 1992-2005 (period 2)...
December 9, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27934168/highly-efficient-silver-cobalt-composite-nanotube-electrocatalysts-for-favorable-oxygen-reduction-reaction
#20
Areum Yu, Chongmok Lee, Nam-Suk Lee, Myung Hwa Kim, Youngmi Lee
This paper reports the synthesis and characterization of silver-cobalt (AgCo) bimetallic composite nanotubes. Cobalt oxide (Co3O4) nanotubes were fabricated by electrospinning and subsequent calcination in air and then reduced to cobalt (Co) metal nanotubes via further calcination under a H2/Ar atmosphere. As-prepared Co nanotubes were then employed as templates for the following galvanic replacement reaction (GRR) with silver (Ag) precursor (AgNO3), which produced AgCo composite nanotubes. Various AgCo nanotubes were readily synthesized with applying different reaction times for the reduction of Co3O4 nanotubes and GRR...
December 7, 2016: ACS Applied Materials & Interfaces
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