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Neonatal skin

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https://www.readbyqxmd.com/read/28208964/infant-and-young-child-feeding-practices-in-infants-receiving-skin-to-skin-care-at-birth-follow-up-of-randomized-cohort
#1
Archana Somashekhar Nimbalkar, Dipen Vasudev Patel, Somashekhar Marutirao Nimbalkar, Vijay Karshanbhai Patel, Dhaval Nileshbhai Patel, Ajay Gajanan Phatak
INTRODUCTION: Skin to Skin Care (SSC) in neonatal period influences immediate breastfeeding outcomes in early childhood, especially the duration of exclusive breastfeeding. AIM: We investigated influence of 17 hours of SSC given from day one of life on Infant and Young Child Feeding (IYCF) practices through one year of life. MATERIALS AND METHODS: Follow-up of a Superiority Randomized Control Trial (RCT) (CTRI/2013/06/003790) conducted in a teaching hospital located in central Gujarat...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28205208/skin-to-skin-care-for-procedural-pain-in-neonates
#2
REVIEW
Celeste Johnston, Marsha Campbell-Yeo, Timothy Disher, Britney Benoit, Ananda Fernandes, David Streiner, Darlene Inglis, Rebekah Zee
BACKGROUND: Skin-to-skin care (SSC), often referred to as 'kangaroo care' (KC) due to its similarity with marsupial behaviour of ventral maternal-infant contact, is one non-pharmacological intervention for pain control in infants. OBJECTIVES: The primary objectives were to determine the effect of SSC alone on pain from medical or nursing procedures in neonates compared to no intervention, sucrose or other analgesics, or additions to simple SSC such as rocking; and to determine the effects of the amount of SSC (duration in minutes), method of administration (e...
February 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28198744/the-validity-and-reliability-of-the-turkish-version-of-the-neonatal-skin-risk-assessment-scale
#3
Çiğdem Sari, Naime Altay
PURPOSE: The study created a Turkish translation of the Neonatal Skin Risk Assessment Scale (NSRAS) that was developed by Huffines and Longsdon in 1997. Study authors used a cross-sectional survey design in order to determine the validity and reliability of the Turkish translation. SUBJECTS AND SETTING: The study was conducted at the neonatal intensive care unit of a university hospital in Ankara between March 15 and June 30, 2014. The research sample included 130 neonatal assessments from 17 patients...
March 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28196316/common-skin-conditions-in-children-neonatal-skin-lesions
#4
Brian Z Rayala, Dean S Morrell
Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Clinicians need to recognize these benign skin conditions and differentiate them from more serious conditions, such as infectious pustular eruptions from bacterial, viral, and fungal causes, and inflammatory conditions, such as Langerhans cell histiocytosis...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28194635/using-the-slug-mucosal-irritation-assay-to-investigate-the-tolerability-of-tablet-excipients-on-human-skin-in-the-context-of-the-use-of-a-nipple-shield-delivery-system
#5
Richard Kendall, Joke Lenoir, Stephen Gerrard, Rebekah L Scheuerle, Nigel K H Slater, Catherine Tuleu
PURPOSE: Neonates are particularly challenging to treat. A novel patented drug delivery device containing a rapidly disintegrating tablet held within a modified nipple shield (NSDS) was designed to deliver medication to infants during breastfeeding. However concerns exist around dermatological nipple tolerability with no pharmaceutical safety assessment guidance to study local tissue tolerance of the nipple and the areola. This is the first Slug Mucosal Irritation (SMI) study to evaluate irritancy potential of GRAS excipients commonly used to manufacture rapidly disintegrating immediate release solid oral dosage form METHODS: Zinc sulphate selected as the antidiarrheal model drug that reduces infant mortality, was blended with functional excipients at traditional levels [microcrystalline cellulose, sodium starch glycolate, croscarmellose sodium, magnesium stearate]...
February 13, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28194281/effects-of-father-neonate-skin-to-skin-contact-on-attachment-a-randomized-controlled-trial
#6
Er-Mei Chen, Meei-Ling Gau, Chieh-Yu Liu, Tzu-Ying Lee
This study examines how skin-to-skin contact between father and newborn affects the attachment relationship. A randomized controlled trial was conducted at a regional teaching hospital and a maternity clinic in northern Taiwan. The study recruited 83 first-time fathers aged 20 years or older. By block randomization, participants were allocated to an experimental (n = 41) or a control (n = 42) group. With the exception of skin-to-skin contact (SSC), participants from each group received the same standard care...
2017: Nursing Research and Practice
https://www.readbyqxmd.com/read/28191778/generation-of-human-induced-pluripotent-stem-cell-derived-bona-fide-neural-stem-cells-for-ex-vivo-gene-therapy-of-metachromatic-leukodystrophy
#7
Vasco Meneghini, Giacomo Frati, Davide Sala, Silvia De Cicco, Marco Luciani, Chiara Cavazzin, Marianna Paulis, Wieslawa Mentzen, Francesco Morena, Serena Giannelli, Francesca Sanvito, Anna Villa, Alessandro Bulfone, Vania Broccoli, Sabata Martino, Angela Gritti
Allogeneic fetal-derived human neural stem cells (hfNSCs) that are under clinical evaluation for several neurodegenerative diseases display a favorable safety profile, but require immunosuppression upon transplantation in patients. Neural progenitors derived from patient-specific induced pluripotent stem cells (iPSCs) may be relevant for autologous ex vivo gene-therapy applications to treat genetic diseases with unmet medical need. In this scenario, obtaining iPSC-derived neural stem cells (NSCs) showing a reliable "NSC signature" is mandatory...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28179126/vitamin-d-deficiency-in-mothers-neonates-and-children
#8
Deena H Elsori, Majeda S Hammoud
Vitamin D is produced in response to the exposure of skin to sunlight through UV-B synthesis. It can also be obtained from diet and dietary supplements. Vitamin D is essential for strong bones as it helps to absorb calcium from diet. Vitamin D deficiency mainly occurs if strict vegetarian diet is followed as mostly the source of vitamin D is animal based; therefore, exposure to sunlight is restricted or having dark skin color. Low vitamin D levels results in increased possibility of gestational diabetes among pregnant women, low birth weight and pre-eclampsia in infants, and mothers may suffer bone impairment, osteoporosis, hypocalcaemia, and hypertension...
February 5, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28170341/the-effects-of-antenatal-glucocorticoid-exposure-on-fetal-and-neonatal-skin-maturation
#9
Deanne August, Yogavijayan Kandasamy
AIMS: The use of antenatal glucocorticoids in women with preterm labor has dramatically improved outcomes for premature infants. The most commonly used antenatal glucocorticoids are betamethasone and dexamethasone. Glucocorticoids accelerate fetal lung growth by several mechanisms, including the maturation of type II pneumocytes enabling surfactant production. Furthermore, the lipids in the lung share similarity with those in the skin. Therefore, antenatal administration of glucocorticoids may have effects on the structure and function of the developing epidermal barrier in fetuses and neonates...
February 7, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28160271/topical-anaesthesia-for-needle-related-pain-in-newborn-infants
#10
REVIEW
Jann P Foster, Christine Taylor, Kaye Spence
BACKGROUND: Hospitalised newborn neonates frequently undergo painful invasive procedures that involve penetration of the skin and other tissues by a needle. One intervention that can be used prior to a needle insertion procedure is application of a topical local anaesthetic. OBJECTIVES: To evaluate the efficacy and safety of topical anaesthetics such as amethocaine and EMLA in newborn term or preterm infants requiring an invasive procedure involving puncture of skin and other tissues with a needle...
February 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28156021/loss-of-cutaneous-microbial-diversity-during-first-three-weeks-of-life-in-very-low-birth-weight-infants
#11
A Salava, V Aho, E Lybeck, P Pereira, L Paulin, I Nupponen, A Ranki, P Auvinen, S Andersson, A Lauerma
Neonatal sepsis (NS) is a frequent problem in neonatal intensive care, especially in preterm and very low birth weight (VLBW) infants. The objective of the study was to characterize the cutaneous bacterial microbiome in VLBW infants treated in the neonatal intensive care unit (NICU). Non-invasive skin microbiome specimens were taken repeatedly from 12 VLBW infants during treatment in NICU starting on the first day of life. All infants received benzylpenicillin and netilmicin during the first 1-5 postnatal days...
February 3, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28153467/water-balance-in-the-fetus-and-neonate
#12
REVIEW
Julie B Lindower
Fetal water balance is dependent prenatally on the placental transfer of water from maternal to fetal circulation. Adequate amniotic fluid volume is one indicator of stable fetal status and development. Excessive or less than expected amniotic fluid volume may be a precursor to postnatal morbidity and mortality. Postnatal transition is marked by predictable changes in body water including contraction of extracellular volume and insensible fluid loss, primarily across the skin barrier. The degree to which these occur is determined by gestational and postnatal age...
January 30, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28146586/making-the-continuum-of-care-work-for-mothers-and-infants-does-gender-equity-matter-findings-from-a-quasi-experimental-study-in-bihar-india
#13
Lotus McDougal, Yamini Atmavilas, Katherine Hay, Jay G Silverman, Usha K Tarigopula, Anita Raj
BACKGROUND: Improvements in continuum of care (CoC) utilization are needed to address inadequate reductions in neonatal and infant mortality in India and elsewhere. This study examines the effect of Ananya, a health system training and community outreach intervention, on reproductive, maternal and newborn health continuum of care (RMNH CoC) utilization in Bihar, India, and explores whether that effect is moderated by gender equity factors (child marriage, restricted mobility and low decision-making control)...
2017: PloS One
https://www.readbyqxmd.com/read/28141600/preventing-pressure-injuries-in-neonates-undergoing-therapeutic-hypothermia-for-hypoxic-ischemic-encephalopathy-an-interprofessional-quality-improvement-project
#14
Alexandra Luton, Jae Hernandez, Clive Robert Patterson, Jill Nielsen-Farrell, Anita Thompson, Jeffrey R Kaiser
BACKGROUND: Hospital-acquired pressure injuries (HAPIs) can be caused by multiple factors including pressure, shear, friction, moisture/incontinence, device-related pressure, immobility, inactivity, and nutritional deficits. Along with immobility, medical device-related (MDR) HAPIs are a primary cause of pressure injury in neonates, as the clinical practice setting has become increasingly technologically advanced. It is estimated that up to 50% of HAPIs are MDR in pediatric patients. Neonates are at particular risk for HAPI because of their specific anatomical, physiological, and developmental vulnerabilities...
January 30, 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/28130432/azithromycin-in-labor-lowers-clinical-infections-in-mothers-and-newborns-a-double-blind-trial
#15
Claire Oluwalana, Bully Camara, Christian Bottomley, Sean Goodier, Abdoulie Bojang, Beate Kampmann, Samba Ceesay, Umberto D'Alessandro, Anna Roca
BACKGROUND AND OBJECTIVES: We have recently completed a proof-of-concept trial showing that bacterial colonization decreased in women and newborns after the administration of azithromycin during labor. Here, we aim to assess the effect of the intervention on maternal and neonatal clinical infections. METHODS: This was a double-blind, placebo-controlled randomized trial. Gambian women in labor were given either an oral dose of azithromycin (2 g) or placebo. Follow-up was conducted for 8 weeks after delivery...
February 2017: Pediatrics
https://www.readbyqxmd.com/read/28126049/molecular-epidemiological-survey-of-treponema-pallidum-in-pregnant-women-in-the-zhabei-district-of-shanghai
#16
Yingying Lu, Qi Wu, Li Wang, Lingting Ji
:  Objectives: To evaluate the epidemiological characteristics of syphilis, such as incidence, vertical transmission, and genotypes, in pregnant women in the Zhabei District of Shanghai. In addition, the changes in genotypes and the efficiency of genotyping was evaluated. METHODS: We screened 3,022 pregnant women for syphilis in the Shanghai Zhabei Central Hospital; Whole blood , plasma, earlobe blood, and specimens from genital ulcers or skin/mucosal lesions were collected from syphilis positive patients...
January 24, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28124460/skin-regeneration-stimulation-the-role-of-pcl-platelet-gel-nanofibrous-scaffold
#17
Parviz Ranjbarvan, Masoud Soleimani, Ali Samadi Kuchaksaraei, Jafar Ai, Reza Faridi Majidi, Javad Verdi
Skin is the largest organ of the human body. Thus far, tissue engineering of skin has developed rapidly and has used many types of growth factors and nanofibrous scaffolds. In this study, we differentiated neonate keratinocytes for epithelialization on the polycaprolactone-Platelet gel (PCL-PG) scaffold. Fabricated PCL nanofibers prepared by electrospinning technology and coated by platelet gel. Subsequently, the structure of the scaffold was evaluated by SEM, FTIR-ATR, contact angle and tensile test assays...
January 25, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28123337/a-harmful-traditional-practice-in-newborns-with-adrenocorticotropic-hormone-resistance-syndrome-branding
#18
Osman Baştuğ, Levent Korkmaz, Sabriye Korkut, Hülya Halis, Tamer Güneş, Selim Kurtoğlu
Branding refers to a traditional practice of creating 'therapeutic' burns with hot iron rods over the skin in order to treat various diseases. Although branding is a harmful practice for the body, it has been used for various illnesses including physiologic jaundice in newborns, pneumonia, and convulsions. It causes serious morbidity and delays seeking proper medical care in neonates. Innovations of modern medicine and the use of evidence-based medicine should be preferred instead of these traditional practices...
December 2016: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/28122592/barriers-and-enablers-of-health-system-adoption-of-kangaroo-mother-care-a-systematic-review-of-caregiver-perspectives
#19
Emily R Smith, Ilana Bergelson, Stacie Constantian, Bina Valsangkar, Grace J Chan
BACKGROUND: Despite improvements in child survival in the past four decades, an estimated 6.3 million children under the age of five die each year, and more than 40% of these deaths occur in the neonatal period. Interventions to reduce neonatal mortality are needed. Kangaroo mother care (KMC) is one such life-saving intervention; however it has not yet been fully integrated into health systems around the world. Utilizing a conceptual framework for integration of targeted health interventions into health systems, we hypothesize that caregivers play a critical role in the adoption, diffusion, and assimilation of KMC...
January 25, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28112736/maturation-of-the-infant-microbiome-community-structure-and-function-across-multiple-body-sites-and-in-relation-to-mode-of-delivery
#20
Derrick M Chu, Jun Ma, Amanda L Prince, Kathleen M Antony, Maxim D Seferovic, Kjersti M Aagaard
Human microbial communities are characterized by their taxonomic, metagenomic and metabolic diversity, which varies by distinct body sites and influences human physiology. However, when and how microbial communities within each body niche acquire unique taxonomical and functional signatures in early life remains underexplored. We thus sought to determine the taxonomic composition and potential metabolic function of the neonatal and early infant microbiota across multiple body sites and assess the effect of the mode of delivery and its potential confounders or modifiers...
January 23, 2017: Nature Medicine
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