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https://www.readbyqxmd.com/read/28652565/ketoacidosis-in-neonatal-diabetes-mellitus-part-of-wolcott-rallison-syndrome
#1
Poorna Gopal Azad Sreeramaneni, Subba Rao V Ambula
BACKGROUND Neonatal diabetes mellitus is a rare condition and it is important to differentiate it from other causes, such as hyperglycemia in infancy, for better outcomes. We report a case of an infant who presented to our neonatal intensive care unit in ketoacidosis and a comatose state. CASE REPORT Our case was an infant who presented to the neonatal intensive care unit at 38 days of age in ketoacidosis. The female infant, born to consanguineous parents (first cousins), weighing 2,300 grams at birth, presented with extreme dehydration and pale skin...
June 27, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28649905/juvenile-idiopathic-arthritis-in-a-patient-with-previous-diagnosis-of-severe-congenital-lupus
#2
I H Rotstein Grein, W Armbrust, A M van der Molen, A van Royen-Kerkhof
Neonatal lupus (NL) is an acquired autoimmune disease of the newborn, caused by transplacental passage of the maternal autoantibodies anti SS-A/Ro and anti SS-B/La. When the clinical picture starts directly at birth, it is known as congenital lupus (CL). The clinical manifestations are variable. Except for cardiac involvement, the other manifestations tend to be benign, and resolve with the child's clearance of maternal antibodies. We report a patient who presented at birth with very severe involvement of the skin, and subsequent contractures of hands and feet, leading to functional impairment...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28625784/heightened-sympathetic-arousal-is-demonstrated-by-skin-conductance-responsivity-to-auditory-stimuli-in-a-small-cohort-of-neonates-with-opiate-withdrawal
#3
Christiana N Oji-Mmuo, Fumiyuki Chin Gardner, Kim K Doheny
To determine the effects of auditory stimulus on skin conductance (SC) in infants with severe neonatal abstinence syndrome (NAS) that required morphine treatment (MT) compared with NAS infants that did not require morphine treatment (non-MT). We prospectively enrolled opiate-exposed term infants without polysubstance exposure. Skin conductance responses to an auditory stimulus (ringing a bell for 3seconds) near the time of discharge were obtained. Skin conductance was measured before, during, and after the stimulus...
June 15, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28607955/wound-healing-protects-against-chemotherapy-induced-alopecia-in-young-rats-via-up-regulating-interleukin-1%C3%AE-mediated-signaling
#4
Olivera Stojadinovic, Tongyu C Wikramanayake, Alexandra C Villasante Fricke, Natalie C Yin, Liang Liang, Eleanor Hinde, Julia Escandon, Marjana Tomic-Canic, David M Ansell, Ralf Paus, Joaquin J Jimenez
Wound healing is a complex process regulated by various cell types and a plethora of mediators. While interactions between wounded skin and the hair follicles (HFs) could induce HF neogenesis or promote wound healing, it remains unknown whether the wound healing-associated signaling milieu can be manipulated to protect against alopecia, such as chemotherapy-induced alopecia (CIA). Utilizing a well-established neonatal rat model of CIA, we show here that skin wounding protects from alopecia caused by several clinically relevant chemotherapeutic regimens, and that protection is dependent on the time of wounding and hair cycle stage...
May 2017: Heliyon
https://www.readbyqxmd.com/read/28601861/electrical-grounding-improves-vagal-tone-in-preterm-infants
#5
Rohit Passi, Kim K Doheny, Yuri Gordin, Hans Hinssen, Charles Palmer
BACKGROUND: Low vagal tone (VT) is a marker of vulnerability to stress and the risk of developing necrotizing enterocolitis in preterm infants. Electric fields produced by equipment in the neonatal intensive care unit (NICU) induce an electric potential measurable on the skin in reference to ground. An electrical connection to ground reduces the skin potential and improves VT in adults. OBJECTIVES: We aimed to measure the electric field strengths in the NICU environment and to determine if connecting an infant to electrical ground would reduce the skin potential and improve VT...
June 10, 2017: Neonatology
https://www.readbyqxmd.com/read/28596234/cathepsin-b-as-a-potential-cystatin-m-e-target-in-the-mouse-hair-follicle
#6
Merel A W Oortveld, Ivonne M J J van Vlijmen-Willems, Ferry F J Kersten, Tsing Cheng, Martijn Verdoes, Piet E J van Erp, Sjef Verbeek, Thomas Reinheckel, Wiljan J A J Hendriks, Joost Schalkwijk, Patrick L J M Zeeuwen
Deficiency of the cysteine protease inhibitor cystatin M/E (Cst6) in mice leads to disturbed epidermal cornification, impaired barrier function, and neonatal lethality. We report the rescue of the lethal skin phenotype of ichq (Cst6-deficient; Cst6(-/-)) mice by transgenic, epidermis-specific, reexpression of Cst6 under control of the human involucrin (INV) promoter. Rescued Tg(INV-Cst6)Cst6(ichq/ichq) mice survive the neonatal phase, but display severe eye pathology and alopecia after 4 mo. We observed keratitis and squamous metaplasia of the corneal epithelium, comparable to Cst6(-/-)Ctsl(+/-) mice, as we have reported in other studies...
June 8, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28592938/thermal-burn-in-a-30-minute-old-newborn-report-on-the-youngest-patient-with-iatrogenic-burn-injury
#7
L Abboud, G Ghanimeh
Burns in infants are rare. The majority of neonatal burns occur in the hospital setting. The immaturity of their immune system, their fragile and thin skin, difficulties in resuscitation, engraftment paucity limited by donor sites, and long-term complications make taking care of burned newborns extremely difficult. We present the case of a newborn burned 30 minutes after his birth over a total body surface of 35%, when the hot water bottle used in the hospital accidentally burst. This is the earliest iatrogenic burn in a newborn reported to date...
March 31, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28592313/impact-of-community-initiated-kangaroo-mother-care-on-survival-of-low-birth-weight-infants-study-protocol-for-a-randomized-controlled-trial
#8
Sarmila Mazumder, Sunita Taneja, Suresh Kumar Dalpath, Rakesh Gupta, Brinda Dube, Bireshwar Sinha, Kiran Bhatia, Sachiyo Yoshida, Ole Frithjof Norheim, Rajiv Bahl, Halvor Sommerfelt, Nita Bhandari, Jose Martines
BACKGROUND: Around 70% neonatal deaths occur in low birth weight (LBW) babies. Globally, 15% of babies are born with LBW. Kangaroo Mother Care (KMC) appears to be an effective way to reduce mortality and morbidity among LBW babies. KMC comprises of early and continuous skin-to-skin contact between mother and baby as well as exclusive breastfeeding. Evidence derived from hospital-based studies shows that KMC results in a 40% relative reduction in mortality, a 58% relative reduction in the risk of nosocomial infections or sepsis, shorter hospital stay, and a lower risk of lower respiratory tract infections in babies with birth weight <2000 g...
June 7, 2017: Trials
https://www.readbyqxmd.com/read/28577532/parasitic-outbreak-of-the-copepod-balaenophilus-manatorum-in-neonate-loggerhead-sea-turtles-caretta-caretta-from-a-head-starting-program
#9
J L Crespo-Picazo, D García-Parraga, F Domènech, J Tomás, F J Aznar, J Ortega, J M Corpa
BACKGROUND: Diseases associated to external parasitosis are scarcely reported in sea turtles. During the last decades several organism have been documented as a part of normal epibiont community connected to sea turtles. The copepod Balaenophilus manatorum has been cited as a part of epibiont fauna with some concern about its parasitic capacity. This study serves three purposes, i.e. (i) it sheds light on the type of life style that B. manatorum has developed with its hosts, particularly turtles; (ii) it makes a cautionary note of the potential health risks associated with B...
June 2, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28574146/niemann-pick-type-c-as-a-cause-of-progressive-intellectual-and-neurological-deterioration-in-childhood
#10
Anne Marie Winstone, Lesley Ann Stellitano, Christopher Michael Verity
AIM: To describe the cases of Niemann-Pick type C (NP-C) disease in a United Kingdom epidemiological study of progressive intellectual and neurological deterioration in childhood. METHOD: Paediatricians notified cases via the British Paediatric Surveillance Unit between 1997 and 2015. RESULTS: Fifty-three NP-C patients were identified: 29 females, 24 males. Fifteen cases had a systemic presentation (neonatal jaundice and/or hepatosplenomegaly)...
June 2, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28572736/asthma-like-airway-inflammation-and-responses-in-a-rat-model-of-atopic-dermatitis-induced-by-neonatal-capsaicin-treatment
#11
Rafael Taeho Han, Sewon Kim, Kyungmin Choi, Hyeonseok Jwa, JaeHee Lee, Hye Young Kim, Hee Jin Kim, Hang-Rae Kim, Seung Keun Back, Heung Sik Na
Recent studies have shown that approximately 70% of patients with severe atopic dermatitis (AD) develop asthma. Development of AD in infancy and subsequent other atopic diseases such as asthma in childhood is referred to as atopic march. However, a causal link between the diseases of atopic march has remained largely unaddressed, possibly due to lack of a proper animal model. Recently, we developed an AD rat model showing chronically relapsing dermatitis and scratching behaviors induced by neonatal capsaicin treatment...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28570460/lesions-associated-with-calcium-gluconate-extravasation-presentation-of-5-clinical-cases-and-analysis-of-cases-published
#12
Francisco Javier Pacheco Compaña, José Midón Míguez, Francisco Javier de Toro Santos
INTRODUCTION: Calcium gluconate extravasation is a process, which, while not common, occurs more frequently in neonatal intensive care units. The aim of this study is to present a number of cases of calcium gluconate extravasation, which have occurred in our hospital, and to carry out a review of those clinical cases published in the literature to obtain relevant epidemiological data. METHODS: Data were gathered on the medical histories of 5 patients who presented lesions secondary to calcium gluconate extravasation in our center...
May 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28569788/disease-linked-connexin26-s17f-promotes-volar-skin-abnormalities-and-mild-wound-healing-defects-in-mice
#13
Eric Press, Katanya C Alaga, Kevin Barr, Qing Shao, Felicitas Bosen, Klaus Willecke, Dale W Laird
Several mutant mice have been generated to model connexin (Cx)-linked skin diseases; however, the role of connexins in skin maintenance and during wound healing remains to be fully elucidated. Here we generated a novel, viable, and fertile mouse (Cx26(CK14-S17F/+)) with the keratitis-ichthyosis-deafness mutant (Cx26S17F) driven by the cytokeratin 14 promoter. This mutant mouse mirrors several Cx26-linked human skin pathologies suggesting that the etiology of Cx26-linked skin disease indeed stems from epidermal expression of the Cx26 mutant...
June 1, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28554355/implementing-skin-to-skin-contact-for-cesarean-birth
#14
Margaret M Boyd
Early skin-to-skin (STS) contact in the OR facilitates the development of mothering behaviors, breastfeeding success, and newborn adaptation to extrauterine life. A team at my institution performed a quality improvement project to implement a standard of care for STS contact in the OR during and after cesarean birth. Thirty-seven of 50 mother-infant dyads experienced STS contact in the OR or in the postanesthesia care unit. Twenty-five mothers and newborns who experienced STS contact did so on the OR bed. The median time newborns spent engaged in STS contact with their mothers was 42 minutes and 30 seconds...
June 2017: AORN Journal
https://www.readbyqxmd.com/read/28543629/epidemiology-and-predisposing-factors-for-erythema-toxicum-neonatorum-and-transient-neonatal-pustular-a-multicenter-study
#15
Flávia Pereira Reginatto, Fernanda Mello Muller, Juliano Peruzzo, Tania Ferreira Cestari
BACKGROUND/OBJECTIVES: Erythema toxicum neonatorum (ETN) and transient neonatal pustular melanosis (TNPM) are benign pustular skin conditions that are relatively common in newborns, but the predisposing factors for these conditions are unknown. Our goal was to verify the prevalence of ETN and TNPM and their predisposing factors in a large sample of neonates. METHODS: In this prospective 1-year multicenter study, 2,831 neonates (age ≤72 hours) born in southern Brazil were randomized to undergo skin examination by a dermatologist...
May 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28542663/-periorbital-pallor-post-application-of-mydriatic-in-infants-with-hydrocephalus-associated-to-systemic-effects
#16
Jorge Luis Alvarado Socarras, Sandra Consuelo Rodríguez
Adequate pupil dilation is needed to evaluate some neonates at risk of developing illness during this stage. However, this procedure is not free of adverse effects, either local or systemic. One of these complications is the local vasoconstriction of the preterm baby’s skin following the application of mydriatic eye drops. OBJECTIVE: To describe secondary local and systemic complications of pharmacological pupil dilation in 2 newborns. Clinical case 1: Full term baby with diagnosis of low-birth weight and hydrocephalia...
April 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28538795/neonatal-near-miss-and-mortality-factors-associated-with-life-threatening-conditions-in-newborns-at-six-public-maternity-hospitals-in-southeast-brazil
#17
Pauline Lorena Kale, Maria Helena Prado de Mello-Jorge, Kátia Silveira da Silva, Sandra Costa Fonseca
We aimed to evaluate factors associated with cases of neonatal near miss and neonatal deaths at six public maternity hospitals in São Paulo and Rio de Janeiro States, Brazil, in 2011. A prospective hospital-based birth cohort investigated these outcomes among live births with life-threatening conditions. Associations were tested using multinomial logistic regression models with hierarchical levels. High rates of near miss were observed for maternal syphilis (52.2‰ live births) and lack of prenatal care (80...
May 18, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28524216/-update-on-congenital-and-neonatal-herpes-infections-infection-due-to-cytomegalovirus-and-herpes-simplex
#18
F Baquero-Artigao
Newborn infants are a population which is especially susceptible to viral infections that frequently affect the central nervous system. Herpes infections can be transmitted to the foetus and to the newborn infant, and give rise to severe clinical conditions with long-term sensory and cognitive deficits. Two thirds of newborn infants with encephalitis due to herpes simplex virus and half of the children with symptomatic congenital infection by cytomegalovirus develop sequelae, which results in high community health costs in the long term...
May 17, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28522113/neonatal-glaucoma-associated-with-juvenile-xanthogranuloma-case-report
#19
A Ramos Suárez, I Ayet Roger, A Serra Castanera
CASE REPORT: The case concerns a 22 day-old male child with juvenile xanthogranuloma (JXG), which manifested as a unilateral glaucoma and with fibrinous haemorrhagic exudate in the anterior chamber affecting the angle of the right eye. Despite a high level of suspicion, the definitive diagnosis was not possible until the infant reached the age of 10 months, after the appearance of the skin lesions typical of this condition and histopathological study of them. CONCLUSION: JXG is a rare disease, characterised by yellowish skin lesions on the trunk, neck, or head...
May 15, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28514970/transmission-of-st8-usa300-latin-american-variant-methicillin-resistant-staphylococcus-aureus-on-a-neonatal-intensive-care-unit-recurrent-skin-and-soft-tissue-infections-as-a-marker-for-epidemic-community-associated-mrsa-colonization
#20
Dennis Nurjadi, Sabrina Klein, Stefan Zimmermann, Klaus Heeg, Philipp Zanger
No abstract text is available yet for this article.
May 18, 2017: Infection Control and Hospital Epidemiology
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