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https://www.readbyqxmd.com/read/29691836/early-life-regional-and-temporal-variation-in-filaggrin-derived-natural-moisturising-factor-filaggrin-processing-enzyme-activity-corneocyte-phenotypes-and-plasmin-activity-implications-for-atopic-dermatitis
#1
M A McAleer, I Jakasa, N Raj, C P F O'Donnell, M E Lane, A V Rawlings, R Voegeli, W H I McLean, S Kezic, A D Irvine
BACKGROUND: Filaggrin is central to the pathogenesis of atopic dermatitis (AD). The cheeks are a common initiation site of infantile AD. Regional and temporal expression of levels of filaggrin degradation products (natural moisturising factors, NMF), activities of filaggrin processing enzymes (bleomycin hydrolase; BH and calpain-1; C-1) and plasmin, and corneocyte envelope (CE) maturity in early life are largely unknown. OBJECTIVES: We did a cross-sectional, observational study investigating regional and age dependent variations in NMF levels, activity of proteases and CE maturity in stratum corneum (SC) from infants to determine if these could explain the observed predilection sites for AD in early life...
April 25, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29681101/a-patient-with-peripheral-demyelinating-neuropathy-central-dysmyelinating-leukodystrophy-waardenburg-syndrome-and-severe-hypoganglionosis-associated-with-a-novel-sox10-mutation
#2
Yuko Akutsu, Kentaro Shirai, Akira Takei, Yudai Goto, Tomohiro Aoyama, Akimitu Watanabe, Masatoshi Imamura, Takashi Enokizono, Tatsuyuki Ohto, Tetsuo Hori, Keiko Suzuki, Masaharu Hayashi, Kouji Masumoto, Ken Inoue
In this report, we present the case of a female infant with peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease (PCWH) associated with a novel frameshift mutation (c.842dupT) in exon 5, the last exon of SOX10. She had severe hypoganglionosis in the small intestine and entire colon, and suffered from frequent enterocolitis. The persistence of ganglion cells made both the diagnosis and treatment difficult in the neonatal period. She also showed hypopigmentation of the irises, hair and skin, bilateral sensorineural deafness with hypoplastic inner year, severe demyelinating neuropathy with hypotonia, and diffuse brain hypomyelination...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29678409/phototherapy-for-neonatal-hyperbilirubinemia-and-childhood-eczema-rhinitis-and-wheeze
#3
Elizabeth Huiwen Tham, Evelyn Xiu Ling Loo, Anne Goh, Oon Hoe Teoh, Fabian Yap, Kok Hian Tan, Keith M Godfrey, Hugo Van Bever, Bee Wah Lee, Yap Seng Chong, Lynette Pei-Chi Shek
BACKGROUND: The pathogenesis of allergic diseases in childhood may be attributed to influences of early environmental stimuli on fetal and neonatal immune regulation. Neonatal hyperbilirubinemia is common in the Asian population and up to 20% of infants require phototherapy. We examined the hypothesis that phototherapy for neonatal hyperbilirubinemia modulates the infant's risk of developing eczema, rhinitis and wheeze in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort...
March 24, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29670758/remote-biomonitoring-of-temperatures-in-mothers-and-newborns-design-development-and-testing-of-a-wearable-sensor-device-in-a-tertiary-care-hospital-in-southern-india
#4
Prem K Mony, Prashanth Thankachan, Swarnarekha Bhat, Suman Rao, Maryann Washington, Sumi Antony, Annamma Thomas, Sheela C Nagarajarao, Hiteshwar Rao, Bharadwaj Amrutur
Objective: Newer technologies such as wearables, sensors, mobile telephony and computing offer opportunities to monitor vital physiological parameters and tackle healthcare problems, thereby improving access and quality of care. We describe the design, development and testing of a wearable sensor device for remote biomonitoring of body temperatures in mothers and newborns in southern India. Methods: Based on client needs and technological requirements, a wearable sensor device was designed and developed using principles of 'social innovation' design...
April 2018: BMJ Innovations
https://www.readbyqxmd.com/read/29661239/neonatal-care-practices-in-sub-saharan-africa-a-systematic-review-of-quantitative-and-qualitative-data
#5
REVIEW
Margaret Bee, Anushree Shiroor, Zelee Hill
BACKGROUND: Recommended immediate newborn care practices include thermal care (immediate drying and wrapping, skin-to-skin contact after delivery, delayed bathing), hygienic cord care and early initiation of breastfeeding. This paper systematically reviews quantitative and qualitative data from sub-Saharan Africa on the prevalence of key immediate newborn care practices and the factors that influence them. METHODS: Studies were identified by searching relevant databases and websites, contacting national and international academics and implementers and hand-searching reference lists of included articles...
April 16, 2018: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/29656490/cross-cultural-adaptation-reliability-and-validity-of-the-spanish-version-of-the-neonatal-skin-risk-assessment-scale
#6
Pablo García-Molina, Evelin Balaguer López, José Verdú, Andreu Nolasco, Francisco P García Fernández
AIM: To adapt the Neonatal Skin Risk Assessment Scale to the Spanish context and to test its validity and reliability. BACKGROUND: Currently, in Spain there are no validated scales to evaluate the risk of pressure ulcers in infants. METHOD: The research was performed in 10 neonatal units. Overall, we use an observational study design, but divided it in to three stages. In the first stage, the transcultural adaptation of the scale and its content validation was performed...
April 14, 2018: Journal of Nursing Management
https://www.readbyqxmd.com/read/29630152/lamellar-ichthyosis-in-a-female-neonate-without-a-collodion-membrane
#7
Kevin Chao, Maria Aleshin, Zachary Goldstein, Scott Worswick, Marcia Hogeling
The term, autosomal recessive congenital ichthyosis (ARCI), describes a group of rare genetic skin diseases of cornification involving hyperkeratotic scaling at birth. The defective skin barrier function may lead to dehydration, body temperature instability, and high susceptibility to infections. In most cases of ARCI, neonates are born with a collodion membrane covering the body, often presenting with ectropion and eclabium. We report a premature female neonate presenting with hyperkeratotic scaling at birth without a collodion membrane...
February 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29619393/a-comparative-study-of-maternal-neonate-abdominal-and-kangaroo-skin-to-skin-skin-contact-immediately-after-birth-on-maternal-attachment-behaviors-up-to-2-months
#8
Mohadse Adeli, Maryam Aradmehr
BACKGROUND: Early skin-to-skin maternal-neonate contact during the 1st h following birth prepares both mother and baby to establish a two-way, interactive pattern of interaction. There are few studies on the use of kangaroo care method in term infants and maternal postpartum behavior. OBJECTIVE: The present study aimed to compare abdominal and kangaroo skin contact on maternal attachment behaviors. SETTINGS AND DESIGN: This single-blind randomized clinical trial was performed on 68 eligible pregnant women in Torbat Heydariyeh in 2015...
2018: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29614774/the-brain-intestinal-mucosa-appendix-microbiome-brain-loop
#9
Luis Vitetta, Gemma Vitetta, Sean Hall
The brain and the gut are connected from early fetal life. The mother's exposure to microbial molecules is thought to exert in utero developmental effects on the fetus. These effects could importantly underpin the groundwork for subsequent pathophysiological mechanisms for achieving immunological tolerance and metabolic equilibrium post birth, events that continue through to 3-4 years of age. Furthermore, it is understood that the microbiome promotes cues that instruct the neonate's mucosal tissues and skin in the language of molecular and cellular biology...
April 1, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29613973/genetic-relatedness-of-staphylococcus-haemolyticus-in-gut-and-skin-of-preterm-neonates-and-breast-milk-of-their-mothers
#10
Hiie Soeorg, Hanna Kadri Metsvaht, Evamaria Elisabet Keränen, Imbi Eelmäe, Mirjam Merila, Mari-Liis Ilmoja, Tuuli Metsvaht, Irja Lutsar
BACKGROUND: Staphylococcus haemolyticus is a common colonizer and cause of late-onset sepsis (LOS) in preterm neonates. By describing genetic relatedness, we aimed to determine whether mother's breast milk (BM) is a source of S. haemolyticus colonizing neonatal gut and skin and/or causing LOS. METHODS: S. haemolyticus was isolated from stool and skin swabs of 49 BM-fed preterm neonates admitted to neonatal intensive care unit, 20 healthy BM-fed term neonates and BM of mothers once a week and typed by multilocus variable-number tandem-repeat analysis (MLVA) and multilocus sequence typing (MLST)...
April 2, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29603791/observation-study-showed-that-the-continuity-of-skin-to-skin-contact-with-low-birth-weight-infants-in-uganda-was-sub-optimal
#11
Heather C Watkins, Melissa C Morgan, Harriet Nambuya, Peter Waiswa, Joy E Lawn
AIM: Kangaroo mother care (KMC) is a safe and effective method of reducing neonatal mortality in resource-limited settings, but there has been a lack of data on the duration of skin-to-skin contact (SSC) in busy, low-resource newborn units. Previous studies of intermittent KMC suggest the duration of SSC ranged from 10 minutes to 17 hours per day. METHODS: This was an observational study of newborn infants born weighing less than 2,000 grams, which collected quantitative data on SSC over the first week after birth...
March 30, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29599071/maintaining-normothermia-why-and-how
#12
Daniele Trevisanuto, Daniela Testoni, Maria Fernanda B de Almeida
A high incidence of postnatal hypothermia has been reported in high-as well low-resource countries and it remains an independent predictor of neonatal morbidity and mortality, especially in very preterm infants in all settings. The temperature of newly born infants should be maintained between 36.5 and 37.5 °C after birth through admission and stabilization. Interventions to achieve this may include environmental temperature 23-25 °C, use of radiant warmers, exothermic mattresses, woollen or plastic caps, plastic wraps, humidified and heated gases...
March 21, 2018: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29596733/skin-barrier-in-the-neonate
#13
Alain Taïeb
The purpose of this review is to focus on determinants of skin barrier function in neonates at molecular and cellular levels. The skin barrier is critical in terms of water and gas exchanges during fetal life and undergoes rapid changes at birth, followed by a progressive maturation. Consequences of skin barrier disruption can be extremely detrimental or lethal, as shown in severe genetic epidermal defects. In this context, the fine-tuned rapid adaptation from a liquid to a gaseous milieu is not fully understood...
March 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29596732/introduction-hot-topics-in-neonatal-skin-care-from-the-13th-world-congress-of-pediatric-dermatology-chicago-il-july-6-9-2017
#14
Andrea L Zaenglein
No abstract text is available yet for this article.
March 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29596386/the-role-of-serotonin-during-skin-healing-in-post-thermal-injury
#15
Alia Sadiq, Ahmed Shah, Marc G Jeschke, Cassandra Belo, Muhammad Qasim Hayat, Sheeba Murad, Saeid Amini-Nik
Post-burn trauma significantly raises tissue serotonin concentration at the initial stages of injury, which leads us to investigate its possible role in post burn wound healing. Therefore, we planned this study to examine the role of serotonin in wound healing through in vitro and in vivo models of burn injuries. Results from in vitro analysis revealed that serotonin decreased apoptosis and increased cell survival significantly in human fibroblasts and neonatal keratinocytes. Cellular proliferation also increased significantly in both cell types...
March 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29596071/an-observational-cohort-study-examining-the-effect-of-the-duration-of-skin-to-skin-contact-on-the-physiological-parameters-of-the-neonate-in-a-neonatal-intensive-special-care-unit
#16
Hannah Jones, Nick Santamaria
BACKGROUND: Focus on skin-to-skin contact (SSC) as a family-centered care intervention in Neonatal Intensive Special Care (NISC) Units continues to increase. Previously, SSC has been shown to improve neonatal physiological stability, support brain development, and promote bonding and attachment. Limited research exists investigating SSC duration and neonatal physiological responses. PURPOSE: This study examined the relationship between SSC duration and the neonate's oxygen saturation, heart rate (HR), respiratory rate (RR), and temperature...
March 28, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29593357/patterns-of-acute-bilirubin-encephalopathy-in-nigeria-a-multicenter-pre-intervention-study
#17
Udochukwu M Diala, Richard P Wennberg, Isa Abdulkadir, Zubaida L Farouk, Carlos D Coda Zabetta, Efe Omoyibo, Abieyuwa Emokpae, Aleksandr Aravkin, Bose Toma, Stephen Oguche, Tina Slusher
BACKGROUND: Acute bilirubin encephalopathy (ABE) is an important cause of neonatal morbidity in Nigeria, accounting for 5-14% of neonatal deaths. Most newborns with severe ABE have irreversible damage before receiving treatment emphasizing the need for timely pre-admission monitoring and referral. There is limited evidence that educational interventions targeting mothers and health care providers will reduce delayed care. OBJECTIVE: To provide baseline data on the incidence of ABE and associated pre-admission risk factors in five centers of Nigeria in order to evaluate the effect of subsequent educational interventions on outcome...
March 28, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29584524/impact-of-neonatal-intensive-care-unit-admission-on-bacterial-colonization-of-donated-human-milk
#18
Amir Elmekkawi, Deborah L O'Connor, Debbie Stone, Eugene W Yoon, Michael Larocque, Allison McGeer, Sharon Unger
BACKGROUND: Unpasteurized human donor milk typically contains a variety of bacteria. The impact of neonatal intensive care unit (NICU) admission of the donor's infant and duration of lactation on bacterial contamination of human milk is unknown. Research aim: This study aimed (a) to describe the frequency/concentration of skin commensal bacteria and pathogens in unpasteurized human donor milk and (b) to assess the impact of NICU admission and (c) the duration of milk expression on bacterial colonization of donated milk...
March 1, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29579496/effects-of-bathing-interval-on-skin-condition-and-axillary-bacterial-colonization-in-preterm-infants
#19
Jong Cheul Lee, Yaelim Lee, Ho Ran Park
AIM: The objective of this study was to evaluate the effects of preterm infant bathing periods on skin condition and axillary skin colonization. BACKGROUND: Reducing the frequency of bathing in preterm infants is beneficial in reducing the risk of hypothermia and exposure to stress from frequent nursing contacts. METHODS: The subjects of this study were observed at The V hospital at the C University in South Korea between December 2012 and August 2013...
April 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29568109/mitochondrial-inefficiency-in-infants-born-to-overweight-african-american-mothers
#20
Manjusha Abraham, Christina A Collins, Scott Flewelling, Maraya Camazine, Alison Cahill, W Todd Cade, Jennifer G Duncan
BACKGROUND: Currently 20-35% of pregnant women are obese, posing a major health risk for mother and fetus. It is postulated that an abnormal maternal-fetal nutritional environment leads to adverse metabolic programming, resulting in altered substrate metabolism in the offspring and predisposing to risks of obesity and diabetes later in life. Data indicate that oocytes from overweight animals have abnormal mitochondria. We hypothesized that maternal obesity is associated with altered mitochondrial function in healthy neonatal offspring...
March 3, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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