Victoire Perraud, Bart Vanderhoydonck, Guillaume Bouvier, Guilherme Dias de Melo, Amuri Kilonda, Mohamed Koukni, Dirk Jochmans, Sophie Rogée, Youcef Ben Khalifa, Lauriane Kergoat, Julien Lannoy, Tina Van Buyten, Nadia Izadi-Pruneyre, Patrick Chaltin, Johan Neyts, Arnaud Marchand, Florence Larrous, Hervé Bourhy
Rabies, a viral zoonosis, is responsible for almost 59,000 deaths each year, despite the existence of an effective post-exposure prophylaxis. Indeed, rabies causes acute encephalomyelitis, with a case-fatality rate of 100 % after the onset of neurological clinical signs. Therefore, the development of therapies to inhibit the rabies virus (RABV) is crucial. Here, we identified, from a 30,000 compound library screening, phthalazinone derivative compounds as potent inhibitors of RABV infection and more broadly of Lyssavirus and even Mononegavirales infections...
February 17, 2024: Antiviral Research