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PEP Therapy

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https://www.readbyqxmd.com/read/29772745/tryptophan-containing-dual-neuroprotective-peptides-prolyl-endopeptidase-inhibition-and-caenorhabditis-elegans-protection-from-%C3%AE-amyloid-peptide-toxicity
#1
Paloma Manzanares, Roberto Martínez, Sandra Garrigues, Salvador Genovés, Daniel Ramón, Jose F Marcos, Patricia Martorell
Neuroprotective peptides represent an attractive pharmacological strategy for the prevention or treatment of age-related diseases, for which there are currently few effective therapies. Lactoferrin (LF)-derived peptides (PKHs) and a set of six rationally-designed tryptophan (W)-containing heptapeptides (PACEIs) were characterized as prolyl endopeptidase (PEP) inhibitors, and their effect on β-amyloid peptide (Aβ) toxicity in a Caenorhabditis elegans model of Alzheimer's disease (AD) was evaluated. Two LF-derived sequences, PKH8 and PKH11, sharing a W at the C-terminal end, and the six PACEI heptapeptides (PACEI48L to PACEI53L) exhibited significant in vitro PEP inhibition...
May 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29753322/clinical-outcomes-of-interactive-intensive-and-individual-3i-play-therapy-for-children-with-asd-a-two-year-follow-up-study
#2
Elodie Tilmont Pittala, Yann Saint-Georges-Chaumet, Claire Favrot, Antoine Tanet, David Cohen, Catherine Saint-Georges
BACKGROUND: The outcomes of psycho-educational interventions for Autism Spectrum Disorders (ASDs) comorbid with severe to moderate intellectual disability (ID) are insufficiently documented. In this prospective study, we examined a developmental individual, interactive and intensive approach, called the '3i method', which is based on play therapy. METHODS: Twenty DSM-IV-TR ASD subjects (mean chronological age 63.8 ± 37.8 months; mean developmental age 19.5 ± 6...
May 12, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29732529/osteostimulation-scaffolds-of-stem-cells-bmp-7-derived-peptide-decorated-alginate-porous-scaffolds-promote-the-aggregation-and-osteo-differentiation-of-human-mesenchymal-stem-cells
#3
Yue Yang, Zuyuan Luo, Ying Zhao
The scaffolds for stem cell-based bone tissue engineering should hold the ability to guide stem cells osteo-differentiating. Otherwise, stem cells will differentiate into unwanted cell types or will form tumors in vivo. Alginate, a natural polysaccharide with great biocompatibility, was widely used in biomedical applications. However, the limited bioactivity and poor osteogenesis capability of pristine alginate hampered its further application in tissue engineering. In this work, a bone forming peptide-1 (BFP-1), derived from bone morphogenetic protein-7, was grafted to alginate polymer chains to prepare peptide-decorated alginate porous scaffolds (pep-APS) for promoting osteo-differentiation of human mesenchymal stem cells (hMSCs)...
May 6, 2018: Biopolymers
https://www.readbyqxmd.com/read/29697011/influence-of-the-vibralung-acoustical-percussor-on-pulmonary-function-and-sputum-expectoration-in-individuals-with-cystic-fibrosis
#4
Courtney M Wheatley, Sarah E Baker, Cori M Daines, Hanna Phan, Marina G Martinez, Wayne J Morgan, Eric M Snyder
BACKGROUND: The Vibralung Acoustical Percussor is a new airway clearance therapy (ACT) utilizing intrapulmonary sound waves in addition to positive expiratory pressure (PEP). We evaluated the safety of the Vibralung and collected preliminary data on its ability to mediate sputum expectoration in individuals with cystic fibrosis (CF). METHODS: Over two separate studies, 10 and 11 mild to moderate CF patients were recruited for study I and II, respectively. Study I: Vibralung was used for 20 min with either no sound (NS: PEP only) or sound (S: PEP and sound) on randomized visits...
January 2018: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/29676342/audit-of-prevention-of-mother-to-child-transmission-programme-interventions-in-hiv-exposed-children-at-national-hospital-abuja-nigeria
#5
Mariya Mukhtar-Yola, Adekunle Tolulope Otuneye, Amsa Baba Mairami, Yewande Wey, Vincent Nwatah, Lamidi Isah Audu
Background: Ninety percentage of children acquire human immunodeficiency virus (HIV) infection in the form of Mother-to-child Transmission (MTCT). In the absence of interventions, transmission rates range from 15% to 45%. This can be reduced to below 5% with effective interventions. The last published national guideline (NG) on prevention of MTCT (PMTCT) was in 2010. Clinical audits are essential in improving the quality of care delivered to patients. Objectives: The study objectives were to determine the rate of MTCT of HIV in exposed infants at a follow-up clinic between 2011 and 2014 and to determine the level of adherence to 2010 NG on the use of highly active antiretroviral therapy (HAART), polymerase chain reaction (PCR) testing, feeding options, antiretroviral (ARV) prophylaxis and the use of co-trimoxazole (CTZ)...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29606135/fluid-hydration-to-prevent-post-ercp-pancreatitis-in-average-to-high-risk-patients-receiving-prophylactic-rectal-nsaids-fluyt-trial-study-protocol-for-a-randomized-controlled-trial
#6
Xavier J N M Smeets, David W da Costa, Paul Fockens, Chris J J Mulder, Robin Timmer, Wietske Kievit, Marieke Zegers, Marco J Bruno, Marc G H Besselink, Frank P Vleggaar, Rene W M van der Hulst, Alexander C Poen, Gerbrand D N Heine, Niels G Venneman, Jeroen J Kolkman, Lubbertus C Baak, Tessa E H Römkens, Sven M van Dijk, Nora D L Hallensleben, Wim van de Vrie, Tom C J Seerden, Adriaan C I T L Tan, Annet M C J Voorburg, Jan-Werner Poley, Ben J Witteman, Abha Bhalla, Muhammed Hadithi, Willem J Thijs, Matthijs P Schwartz, Jan Maarten Vrolijk, Robert C Verdonk, Foke van Delft, Yolande Keulemans, Harry van Goor, Joost P H Drenth, Erwin J M van Geenen
BACKGROUND: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is the most common complication of ERCP and may run a severe course. Evidence suggests that vigorous periprocedural hydration can prevent PEP, but studies to date have significant methodological drawbacks. Importantly, evidence for its added value in patients already receiving prophylactic rectal non-steroidal anti-inflammatory drugs (NSAIDs) is lacking and the cost-effectiveness of the approach has not been investigated...
April 2, 2018: Trials
https://www.readbyqxmd.com/read/29547616/prevention-of-infection-a-systematic-review-of-evidence-based-practice-interventions-for-management-in-patients-with-cancer
#7
Barbara J Wilson, Laura J Zitella, Colleen H Erb, Jackie Foster, Mary Peterson, Sylvia K Wood
BACKGROUND: Cancer-related infections lead to increases in mortality, antibiotic use, and hospital stays. Other adverse outcomes include dose delays and reductions, which can result in suboptimal treatment outcomes. OBJECTIVES: Effective implementation of risk assessment and evidence-based interventions for the prevention and treatment of infection are essential to improve care and reduce costs related to infections in patients with cancer receiving immunosuppressive therapy...
April 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29487471/nurturing-the-continuum-of-hiv-testing-treatment-and-prevention-matrix-cascade-in-reducing-hiv-transmission
#8
Clarence S Yah
Background: Despite the shift in antiretroviral therapy (ARVs) eligibility cascade from CD4 ≤ 200 to CD4 ≤ 350 to CD4 ≤ 500 mm3 , HIV related morbidity and mortality continue to escalate annually, as do HIV infections. The new paradigm of treatment for all HIV positives individual irrespective of CD4 count may significantly reduce HIV and related illnesses. The author assumes that all HIV infected partners should be eligible for HIV treatment and care, irrespective of CD4 count...
November 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29363329/retraction-notice
#9
(no author information available yet)
At the request of the Journal Editor and the Publisher, the following article has been retracted: Lee I. (2015) The effect of postural control intervention for congenital muscular torticollis: a randomized controlled trial. Clinical Rehabilitation 29(8): 795-802. DOI: 10.1177/0269215514555037. This article demonstrates a high level of unreferenced overlap with the following article: Rahlin, M. (2005) TAMO Therapy as a Major Component of Physical Therapy Intervention for an Infant With Congenital Muscular Torticollis: A Case Report...
March 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29279280/the-path-towards-effective-antivirals-against-rabies
#10
Dirk Jochmans, Johan Neyts
Rabies virus remains an important burden of disease claiming an estimated 60,000 lives each year, mainly children, and having a huge economical and societal cost. Post-exposure prophylaxis (PEP) is highly effective, however in patients that present with neurological symptoms the case-fatality ratio is extremely high (>99%). During the last decades several attempts to identify potent and effective antivirals were made. Only a few of these demonstrated improvement in clinical signs in animal studies and none of the trials in humans showed significant efficacy...
December 23, 2017: Vaccine
https://www.readbyqxmd.com/read/29278971/prevention-strategies-against-hiv-transmission-a-proactive-approach
#11
Antonio J Carrion, Jovan D Miles, Juan F Mosley, Lillian L Smith, April S Prather, Marcus M Gurley, Linh D Phan, Emily C Everton
Human immunodeficiency virus (HIV) has now transformed into a manageable chronic condition. Highly active antiretroviral therapy (HAART) has proven efficacious at controlling the disease progression. Based on compelling evidence, the Department of Health and Human Services (DHHS) and the Infectious Disease Society of America (IDSA) developed guidelines for the management of persons infected with HIV. However, there are approximately 50 000 new cases of HIV in the United States each year. In this article, we review proactive methods to reduce the transmission of HIV, which include reinforcing patient education, gel-coated condoms that destroy HIV, HIV vaccinations, and adequately utilizing pre-exposure prophylaxis (PrEP), and post-exposure prophylaxis (PEP)...
February 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29238654/primary-endocrine-therapy-in-older-women-with-breast-cancer
#12
REVIEW
R M C Pepping, J E A Portielje, W van de Water, N A de Glas
Purpose of Review: Breast cancer incidence increases with age. In recent years, primary endocrine therapy has been increasingly used as a treatment option for frail elderly women with breast cancer, although surgery is still the guideline-recommended treatment. In this review, we discuss the evidence for primary endocrine therapy versus surgical treatment in older women with early breast cancer. Recent Findings: Both randomised controlled trials and recent observational studies showed a favourable progression-free survival but not overall survival for surgery plus adjuvant endocrine therapy versus primary endocrine therapy...
2017: Current Geriatrics Reports
https://www.readbyqxmd.com/read/29222865/multipoint-pacing-improves-peripheral-hemodynamic-response-noninvasive-assessment-using-radial-artery-tonometry
#13
Giuseppe Ciconte, Žarko Ćalović, Gabriele Vicedomini, Amarild Cuko, Luke C McSpadden, Chunlan Jiang, Kyungmoo Ryu, Igor Caporaso, Robert Stutz, Dean Winter, Massimo Saviano, Raffaele Vitale, Manuel Conti, Vincenzo Santinelli, Carlo Pappone
BACKGROUND: Multipoint left ventricular (LV) pacing (MultiPoint™ Pacing [MPP], Abbott, Sylmar, CA, USA) improves the response rate to cardiac resynchronization therapy (CRT). We evaluated the feasibility of noninvasive radial artery tonometry (RAT) to characterize arterial pressure morphology changes (pre-ejection period [PEP] and ejection duration [ED]) between conventional CRT and MPP pacing interventions. METHODS: Patients with a MPP-enabled CRT device (Quadra Assura MP™, Abbott) underwent noninvasive RAT assessment (SphygmoCor CVMS, AtCor Medical Inc...
February 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29207979/a-propeptide-toolbox-for-secretion-optimization-of-flavobacterium-meningosepticum-endopeptidase-in-lactococcus-lactis
#14
Pei Yu Lim, Lee Ling Tan, Dave Siak-Wei Ow, Fong T Wong
BACKGROUND: Lactic acid bacteria are a family of "generally regarded as safe" organisms traditionally used for food fermentation. In recent years, they have started to emerge as potential chassis for heterologous protein production. And more recently, due to their beneficial properties in the gut, they have been examined as potential candidates for mucosal delivery vectors, especially for acid-sensitive enzymes. One such application would be the delivery of gluten-digesting endopeptidases for the treatment of celiac disease...
December 5, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29198923/enteromorpha-and-polysaccharides-from-enteromorpha-ameliorate-loperamide-induced-constipation-in-mice
#15
Xinxiu Ren, Lei Liu, Yaser Gamallat, Bingqiang Zhang, Yi Xin
Slow-transit constipation(STC)is a disease characterized by functional gastrointestinal disorder. Common laxatives used in clinical practice against constipation such as Senna have side effects. Enteromorpha(EP)is a common marine alga, and the polysaccharide extracted from EP has been reported possessing anti-cancer and anti-inflammation effects. The aim of this study is to investigate the effects of EP and Polysaccharides from Enteromorpha (PEP) on loperamide induced constipated mice model and illustrating mechanism of action...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29184942/bone-targeting-poly-ethylene-sodium-phosphate
#16
Yasuhiko Iwasaki, Atsushi Yokota, Akihisa Otaka, Naoyuki Inoue, Akane Yamaguchi, Toru Yoshitomi, Keitaro Yoshimoto, Masashi Neo
Poly(ethylene sodium phosphate) (PEP·Na) showed excellent cytocompatibility and in vivo bone affinity. Moreover, PEP·Na did not interact with thrombin, which is a coagulation-related protein. Because immobilization of therapeutic agents and imaging probes on PEP·Na is easily performed, PEP·Na is a promising polymer for bone-targeted therapies.
December 19, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29183270/results-from-the-post-exposure-prophylaxis-pilot-program-p-quad-demonstration-project-in-los-angeles-county
#17
Matthew R Beymer, Ryan M Kofron, Chi-Hong Tseng, Robert K Bolan, Risa P Flynn, Jennifer M Sayles, Mario J Perez, Wilbert C Jordan, Raphael J Landovitz
Post-exposure prophylaxis (PEP) is a promising but under-utilized strategy for HIV prevention in high-risk populations. Between March 2010 and June 2011, two community-based clinics in Los Angeles County provided PEP in a pilot program to 267 unique individuals. Courses were primarily dispensed to men who have sex with men (84%) and consisted overwhelmingly of a three-drug antiretroviral therapy regimen containing two nucleoside reverse transcriptase inhibitors and either an integrase inhibitor (raltegravir) or a boosted protease inhibitor (lopinavir/ritonavir)...
May 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29172784/good-agreement-between-echocardiography-and-impedance-cardiography-in-the-assessment-of-left-ventricular-performance-in-hypertensive-patients
#18
Rodrigo Nazário Leão, Pedro Marques Da Silva, Rita Marques Pocinho, Marta Alves, Daniel Virella, Roberto Palma Reis
BACKGROUND: Impedance cardiography (ICG) is a noninvasive hemodynamic monitoring tool which can define hypertensive patients' hemodynamic profiles and help to tailor antihypertensive therapy. This study assesses the concordance between ICG-derived indexes used to evaluate left ventricular performance and transthoracic echocardiography (TTE) in hypertensive patients. METHODS: In this IMPEDDANS post-hoc analysis, the ICG-derived indexes are compared with TTE by Bland-Altman method...
November 27, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29091217/tenofovir-disoproxil-fumarate-emtricitabine-plus-ritonavir-boosted-lopinavir-or-cobicistat-boosted-elvitegravir-as-a-single-tablet-regimen-for-hiv-post-exposure-prophylaxis
#19
A Inciarte, L Leal, E González, A León, C Lucero, J Mallolas, B Torres, M Laguno, J Rojas, M Martínez-Rebollar, A González-Cordón, A Cruceta, J A Arnaiz, J M Gatell, F García
Objectives: To assess HIV-1 post-exposure prophylaxis (PEP) non-completion at day 28, comparing ritonavir-boosted lopinavir versus cobicistat-boosted elvitegravir as a single-tablet regimen (STR), using tenofovir disoproxil fumarate/emtricitabine with both of these therapies. Methods: A prospective, open, randomized clinical trial was performed. Individuals attending the emergency room due to potential sexual exposure to HIV and who met criteria for PEP were randomized 1:3 into two groups receiving either 400/100 mg of lopinavir/ritonavir (n = 38) or 150/150 mg of elvitegravir/cobicistat (n = 119), with both groups also receiving 245/200 mg of tenofovir disoproxil fumarate/emtricitabine...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29063592/omega-3-supplementation-associated-with-improved-parent-rated-executive-function-in-youth-with-mood-disorders-secondary-analyses-of-the-omega-3-and-therapy-oats-trials
#20
Anthony T Vesco, Andrea S Young, L Eugene Arnold, Mary A Fristad
BACKGROUND: Improvements in executive functioning (EF) may lead to improved quality of life and lessened functional impairment for children with mood disorders. The aim was to assess the impact of omega-3 supplementation (Ω3) and psychoeducational psychotherapy (PEP), each alone and in combination, on EF in youth with mood disorders. We completed secondary analyses of two randomized controlled trials (RCTs) of Ω3 and PEP for children with depression and bipolar disorder. METHODS: Ninety-five youths with depression or bipolar disorder not otherwise specified/cyclothymic disorder were randomized in 12-week RCTs...
October 24, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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