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PEP Therapy

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https://www.readbyqxmd.com/read/28090570/targeted-inhibition-of-pancreatic-acinar-cell-calcineurin-is-a-novel-strategy-to-prevent-post-ercp-pancreatitis
#1
Abrahim I Orabi, Li Wen, Tanveer A Javed, Tianming Le, Ping Guo, Subramaniam Sanker, David Ricks, Kristy Boggs, John F Eisses, Carlos Castro, Xiangwei Xiao, Krishna Prasadan, Farzad Esni, George K Gittes, Sohail Z Husain
BACKGROUND AND AIMS: There is a pressing need to develop effective preventative therapies for post-ERCP pancreatitis (PEP). We demonstrated that early PEP events are induced through the calcium-activated phosphatase calcineurin and that global calcineurin deletion abolishes PEP in mice. A crucial question is whether acinar cell calcineurin controls the initiation of PEP in vivo. METHODS: We used a mouse model of PEP and examined the effects of in vivo acinar cell-specific calcineurin deletion by either generating a conditional knockout line or infusing a novel AAV-Ela-iCre into the pancreatic duct of a calcineurin floxed line...
January 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27974330/post-exposure-prophylaxis-guidelines-for-children-and-adolescents-potentially-exposed-to-hiv
#2
REVIEW
Alasdair Bamford, Gareth Tudor-Williams, Caroline Foster
UK guidelines for HIV post-exposure prophylaxis (PEP) in adults have recently been updated. Indications for PEP have been modified and there has been a change in the recommended antiretroviral therapy for adults to a combination of raltegravir with tenofovir and emtricitabine (Truvada). Raltegravir and tenofovir are now available in paediatric formulations and offer improved safety and tolerability over previously recommended ritonavir-boosted lopinavir with zidovudine. This guideline provides recommendations for those caring for children potentially exposed to HIV and other bloodborne viruses in primary care, emergency departments, secondary care and specialist paediatric HIV centres...
January 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27939904/mitochondria-targeting-nanoheater-for-enhanced-photothermal-chemo-therapy
#3
Si Chen, Qi Lei, Wen-Xiu Qiu, Li-Han Liu, Di-Wei Zheng, Jin-Xuan Fan, Lei Rong, Yun-Xia Sun, Xian-Zheng Zhang
In this work, mitochondria-targeting gold nanostar (AuNS) and anticarcinogen DOX were co-encapsulated in hyaluronic acid (HA) protective shell for tumor-targeting synergistic photothermal/chemo-therapy. Cationic peptide R8 and mitochondria-targeting pro-apoptotic peptide TPP-KLA were co-decorated on AuNS to form AuNS-pep via Au-S bonds. Then, electronegative HA was further coated on the surface via electrostatic interaction for cancer cell targeting. During the coating process, DOX was also introduced via electrostatic interaction to obtain a versatile nanoplatform AuNS-pep/DOX@HA...
February 2017: Biomaterials
https://www.readbyqxmd.com/read/27898235/postexposure-prophylaxis-after-possible-anthrax-exposure-adherence-and-adverse-events
#4
Leisha D Nolen, Rita M Traxler, Grishma A Kharod, Pallavi A Kache, Stefan Katharios-Lanwermeyer, Katherine A Hendricks, Sean V Shadomy, William A Bower, Dana Meaney-Delman, Henry T Walke
Anthrax postexposure prophylaxis (PEP) was recommended to 42 people after a laboratory incident that involved potential aerosolization of Bacillus anthracis spores in 2 laboratories at the Centers for Disease Control and Prevention in 2014. At least 31 (74%) individuals who initiated PEP did not complete either the recommended 60 days of antimicrobial therapy or the 3-dose vaccine regimen. Among the 29 that discontinued the antimicrobial component of PEP, most (38%) individuals discontinued PEP because of their low perceived risk of infection; 9 (31%) individuals discontinued prophylaxis due to PEP-related minor adverse events, and 10% cited both low risk and adverse events as their reason for discontinuation...
November 2016: Health Security
https://www.readbyqxmd.com/read/27867566/effectiveness-of-temporary-positive-expiratory-pressure-t-pep-at-home-and-at-hospital-in-patients-with-severe-chronic-obstructive-pulmonary-disease
#5
Valentina Mascardi, Bruna Grecchi, Cornelius Barlascini, Paolo Banfi, Antonello Nicolini
BACKGROUND: Temporary positive airway pressure (T-PEP) is a tool recently introduced in the treatment of chronic obstructive pulmonary disease (COPD) or bronchiectasis. It demonstrated encouraging results also in severe COPD patients. The aim of this study is verify if adding T-PEP to best bronchodilator therapy both in clinic and home administering could reduce disease exacerbations and improve lung function in patients with severe COPD. METHODS: A total of 142 patients with severe COPD (FEV1 <50%) were enrolled; 120 were randomized in three groups: a group treated with T-PEP at home, a group with T-PEP at hospital and a group with medical therapy only (control group)...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27833233/effectiveness-of-metacognitive-therapy-in-patients-with-social-anxiety-disorder-a-pilot-investigation
#6
Jayasree Lakshmi, Paulomi Matam Sudhir, Mahendra Prakash Sharma, Suresh Bada Math
: Metacognitive therapy (MCT) is a recent psychological intervention for emotional disorders. Its efficacy in social anxiety disorder (SAD) is yet to be established. AIMS: We examined the effectiveness of an MCT in patients with SAD. A two group case-control design with baseline, post, and 3 months follow-up was adopted. The control group received training in applied relaxation (AR). Four patients with Diagnostic and Statistical Manual-IV diagnosis of social anxiety were sequentially allotted to receive either MCT or AR...
September 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27743287/cu-zn-superoxide-dismutase-increases-the-therapeutic-potential-of-adipose-derived-mesenchymal-stem-cells-by-maintaining-antioxidant-enzyme-levels
#7
Dae Young Yoo, Dae Won Kim, Jin Young Chung, Hyo Young Jung, Jong Whi Kim, Yeo Sung Yoon, In Koo Hwang, Jung Hoon Choi, Goang-Min Choi, Soo Young Choi, Seung Myung Moon
In the present study, we investigated the ability of Cu, Zn-superoxide dismutase (SOD1) to improve the therapeutic potential of adipose tissue-derived mesenchymal stem cells (Ad-MSCs) against ischemic damage in the spinal cord. Animals were divided into four groups: the control group, vehicle (PEP-1 peptide and artificial cerebrospinal fluid)-treated group, Ad-MSC alone group, and Ad-MSC-treated group with PEP-1-SOD1. The abdominal aorta of the rabbit was occluded for 30 min in the subrenal region to induce ischemic damage, and immediately after reperfusion, artificial cerebrospinal fluid or Ad-MSCs (2 × 10(5)) were administered intrathecally...
December 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27682067/hepatitis-c-virus-postexposure-prophylaxis-in-the-healthcare-worker-why-direct-acting-antivirals-don-t-change-a-thing
#8
Susanna Naggie, David P Holland, Mark S Sulkowski, David L Thomas
Currently, 380 000-400 000 occupational exposures to blood-borne pathogens occur annually in the United States. The management for occupational HIV or hepatitis B virus exposures includes postexposure prophylaxis (PEP) when necessary; however, PEP is not recommended for hepatitis C virus (HCV) exposures. Recent approval of HCV direct-acting antivirals (DAAs) has renewed discussions as to whether these therapies could be used to prevent infection after exposure. There are no published studies addressing this question, but the prescribing of DAAs for PEP has been reported...
January 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27636161/enhanced-antiglioblastoma-efficacy-of-neovasculature-and-glioma-cells-dual-targeted-nanoparticles
#9
Lingyan Lv, Yan Jiang, Xin Liu, Baoyan Wang, Wei Lv, Yue Zhao, Huihui Shi, Quanyin Hu, Hongliang Xin, Qunwei Xu, Zhen Gu
Combining treatment of anticancer cells and antiangiogenesis is considered to be a potential targeted strategy for brain glioblastoma therapy. In this study, by utilizing the overexpression of Interleukin 13 receptor α2 (IL-13Rα2) on the glioma cells and heparan sulfate on neovascular endothelial cells, we developed a paclitaxel (PTX) loaded Pep-1 and CGKRK peptide-modified PEG-PLGA nanoparticle (PC-NP-PTX) for glioma cells and neovasculature dual-targeted chemotherapy to enhance the antiglioma efficacy. There were significant differences both on the enhancement of cellular uptake in HUVEC and C6 cells and on the improvement of in vitro antiglioma activity in the respect of proliferation, tumor spheroid growth, tube formation, and migration between PC-NP-PTX and Taxol and NP-PTX...
October 3, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27631366/anti-retroviral-therapy-based-hiv-prevention-among-a-sample-of-men-who-have-sex-with-men-in-cape-town-south-africa-use-of-post-exposure-prophylaxis-and-knowledge-on-pre-exposure-prophylaxis
#10
J M Hugo, R D Stall, K Rebe, J E Egan, G De Swardt, H Struthers, J A McIntyre
Men who have Sex with Men (MSM) have been affected disproportionately by the global HIV pandemic. Rates of consistent condom-use are low and there is a need for further biomedical prevention interventions to prevent new HIV infections. Post exposure prophylaxis (PEP) can reduce the risk of HIV, but uptake among MSM is low. Pre-exposure prophylaxis (PrEP), an innovative anti-retroviral-based HIV prevention tool might be an appropriate intervention for MSM who have recently accessed PEP that involves HIV negative individuals taking daily tenofovir+emtricitabine for HIV prevention...
December 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27604240/psychoeducational-psychotherapy-and-omega-3-supplementation-improve-co-occurring-behavioral-problems-in-youth-with-depression-results-from-a-pilot-rct
#11
Andrea S Young, L Eugene Arnold, Hannah L Wolfson, Mary A Fristad
This pilot randomized controlled trial (RCT) investigated benefits of omega-3 fatty acid supplementation and Individual-Family Psychoeducational Psychotherapy (PEP; a family-focused, cognitive-behavioral therapy) for behavior problems among youth with depression. Participants aged 7-14 with DSM-IV-TR depressive disorders (N = 72; 56.9 % male) were randomized to 1 of 4 treatment conditions: PEP + omega-3, PEP monotherapy (with pill placebo), omega-3 monotherapy, or placebo (without active intervention)...
September 8, 2016: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/27595248/-effectivity-and-security-of-vildagliptin-as-additional-treatment-for-type-2-diabetes-mellitus-in-real-life-conditions-in-mexico-edge-study-subanalysis
#12
COMPARATIVE STUDY
Eduardo Márquez-Rodríguez, Eduardo Brea-Andrea, Victoria Alejandro Rajmet-Hace, Javier Salinas-Salinas, Fabiola Mariño-Rojas
BACKGROUND: The multinational EDGE (Effectiveness of Diabetes control with vildaGliptin and vildagliptin/mEtformin) study assessed the effectiveness and tolerability of vildagliptin versus other oral antihyperglycemic drugs (OAD) when added to monotherapy in patients in the real-world setting. METHODS: Prospective, real-world observational study. The primary endpoint (PEP) was the proportion of patients achieving a reduction in HbA1c > 0.3% without peripheral edema, hypoglycemia, discontinuation, dueto gastrointestinal event, or weight gain > 5%...
July 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27507600/expectations-and-perspectives-of-ovarian-cancer-patients-about-cancer-management-in-romania-the-international-noggo-engot-trial-expression-iii
#13
P Achimaş-Cadariu, M Iancu, P Kubelac, F Pop, I Braicu, C Vlad, G Oskay-Özcelik, J Sehouli
We have investigated a relational model of expectations and preferences among ovarian cancer patients centred on physician-patient communication, treatment approach, and the need for information. Consecutive patients anonymously filled in the EXPRESSION III questionnaire between 2009 and 2012. Following descriptive statistics, structural equation modelling was used to analyse the relationships between physician's evaluation by the patient (PEP), result of therapy (RT), need for changes in treatment (NCT) and patient's desire to be informed (PD)...
August 10, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27474205/impact-of-early-treatment-programs-on-hiv-epidemics-an-immunity-based-mathematical-model
#14
S M Ashrafur Rahman, Naveen K Vaidya, Xingfu Zou
While studies on pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) have demonstrated substantial advantages in controlling HIV transmission, the overall benefits of the programs with early initiation of antiretroviral therapy (ART) have not been fully understood and are still on debate. Here, we develop an immunity-based (CD4+ T cell count based) mathematical model to study the impacts of early treatment programs on HIV epidemics and the overall community-level immunity. The model is parametrized using the HIV prevalence data from South Africa and fully analyzed for stability of equilibria and infection persistence criteria...
October 2016: Mathematical Biosciences
https://www.readbyqxmd.com/read/27431341/psychoeducation-with-problem-solving-peps-therapy-for-adults-with-personality-disorder-a-pragmatic-randomised-controlled-trial-to-determine-the-clinical-effectiveness-and-cost-effectiveness-of-a-manualised-intervention-to-improve-social-functioning
#15
Mary McMurran, Mike J Crawford, Joe Reilly, Juan Delport, Paul McCrone, Diane Whitham, Wei Tan, Conor Duggan, Alan A Montgomery, Hywel C Williams, Clive E Adams, Huajie Jin, Matthew Lewis, Florence Day
BACKGROUND: If effective, less intensive treatments for people with personality disorder have the potential to serve more people. OBJECTIVES: To compare the clinical effectiveness and cost-effectiveness of psychoeducation with problem-solving (PEPS) therapy plus usual treatment against usual treatment alone in improving social problem-solving with adults with personality disorder. DESIGN: Multisite two-arm, parallel-group, pragmatic randomised controlled superiority trial...
July 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27415618/changes-in-hepatic-venous-pressure-gradient-induced-by-physical-exercise-in-cirrhosis-results-of-a-pilot-randomized-open-clinical-trial
#16
Ricardo U Macías-Rodríguez, Hermes Ilarraza-Lomelí, Astrid Ruiz-Margáin, Sergio Ponce-de-León-Rosales, Florencia Vargas-Vorácková, Octavio García-Flores, Aldo Torre, Andrés Duarte-Rojo
OBJECTIVES: Exercise has been scarcely studied in patients with cirrhosis, and prior evidence showed hepatic venous pressure gradient (HVPG) to be increased in response to exercise. The aim of this study was to investigate the effects of a supervised physical exercise program (PEP) in patients with cirrhosis. METHODS: In an open-label, pilot clinical trial, patients with cirrhosis were randomized to PEP (cycloergometry/kinesiotherapy plus nutritional therapy, n=14) or control (nutritional therapy, n=15); for 14 weeks...
2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27376699/differences-in-glycemic-control-across-world-regions-a-post-hoc-analysis-in-patients-with-type-2-diabetes-mellitus-on-dual-antidiabetes-drug-therapy
#17
H Brath, P M Paldánius, G Bader, W M Kolaczynski, P M Nilsson
OBJECTIVE: This post-hoc analysis of the EDGE (Effectiveness of Diabetes control with vildaGliptin and vildagliptin/mEtformin) study assessed inter-regional differences in baseline characteristics and response to treatment intensification with dual oral antidiabetes drugs (OADs) in patients with type 2 diabetes mellitus (T2DM). METHODS: Patients with T2DM inadequately controlled with first-line monotherapy were assigned to receive a dipeptidyl peptidase-4 (DPP-4) inhibitor, vildagliptin, or comparator OADs as add-on dual therapy...
2016: Nutrition & Diabetes
https://www.readbyqxmd.com/read/27320120/-therapy-related-acute-myeloid-leukemia-following-etoposide-based-chemotherapy-in-germ-cell-tumor
#18
Yoshinaga Okumura, Masashi Oae, Yusuke Shiraishi, Takeshi Soda, Hiroshi Kanamaru, Nobuyoshi Arima
A 27-year-old man visited our hospital with painless swelling of the left scrotum. Hematologic studies showed the following levels of lactate dehydrogenase, 3,171 IU/l ; alpha-fetoprotein, 2.2 ng/ml ; and β- human chorionic gonadotropin, 0.4 ng/ml, and abdominal computed tomography revealed a mass of 10×8 ×4 cm in the left testis, and that of 3.5×3.0×5.0 cm in the left renal hilar lymph node, without any other metastasis. Left high inguinal orchiectomy was performed, and histopathological examination revealed mixed form with seminoma and teratoma...
May 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27240380/unobtrusive-estimation-of-cardiac-contractility-and-stroke-volume-changes-using-ballistocardiogram-measurements-on-a-high-bandwidth-force-plate
#19
Hazar Ashouri, Lara Orlandic, Omer T Inan
Unobtrusive and inexpensive technologies for monitoring the cardiovascular health of heart failure (HF) patients outside the clinic can potentially improve their continuity of care by enabling therapies to be adjusted dynamically based on the changing needs of the patients. Specifically, cardiac contractility and stroke volume (SV) are two key aspects of cardiovascular health that change significantly for HF patients as their condition worsens, yet these parameters are typically measured only in hospital/clinical settings, or with implantable sensors...
2016: Sensors
https://www.readbyqxmd.com/read/26941086/rectal-indomethacin-alone-versus-indomethacin-and-prophylactic-pancreatic-stent-placement-for-preventing-pancreatitis-after-ercp-study-protocol-for-a-randomized-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
B Joseph Elmunzer, Jose Serrano, Amitabh Chak, Steven A Edmundowicz, Georgios I Papachristou, James M Scheiman, Vikesh K Singh, Shyam Varadurajulu, John J Vargo, Field F Willingham, Todd H Baron, Gregory A Coté, Joseph Romagnuolo, April Wood-Williams, Emily K Depue, Rebecca L Spitzer, Cathie Spino, Lydia D Foster, Valerie Durkalski
BACKGROUND: The combination of prophylactic pancreatic stent placement (PSP) - a temporary plastic stent placed in the pancreatic duct - and rectal non-steroidal anti-inflammatory drugs (NSAIDs) is recommended for preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in high-risk cases. Preliminary data, however, suggest that PSP may be unnecessary if rectal NSAIDs are administered. Given the costs and potential risks of PSP, we aim to determine whether rectal indomethacin obviates the need for pancreatic stent placement in patients undergoing high-risk ERCP...
March 3, 2016: Trials
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