Jonathan Dugernier, Déborah Le Pennec, Guillaume Maerckx, Laurine Allimonnier, Michel Hesse, Diego Castanares-Zapatero, Virginie Depoortere, Laurent Vecellio, Gregory Reychler, Jean-Bernard Michotte, Pierre Goffette, Marie-Agnes Docquier, Christian Raftopoulos, François Jamar, Pierre-François Laterre, Stephan Ehrmann, Xavier Wittebole
BACKGROUND: The administration technique for inhaled drug delivery during invasive ventilation remains debated. This study aimed to compare in vivo and in vitro the deposition of a radiolabeled aerosol generated through four configurations during invasive ventilation, including setups optimizing drug delivery. METHODS: Thirty-one intubated postoperative neurosurgery patients with healthy lungs were randomly assigned to four configurations of aerosol delivery using a vibrating-mesh nebulizer and specific ventilator settings: (1) a specific circuit for aerosol therapy (SCAT) with the nebulizer placed at 30 cm of the wye, (2) a heated-humidified circuit switched off 30 min before the nebulization or (3) left on with the nebulizer at the inlet of the heated-humidifier, (4) a conventional circuit with the nebulizer placed between the heat and moisture exchanger filter and the endotracheal tube...
December 11, 2023: Annals of Intensive Care