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https://www.readbyqxmd.com/read/29782541/an-unappreciated-role-for-neutrophil-dc-hybrids-in-immunity-to-invasive-fungal-infections
#1
J Scott Fites, Michael Gui, John F Kernien, Paige Negoro, Zeina Dagher, David B Sykes, Jeniel E Nett, Michael K Mansour, Bruce S Klein
Neutrophils are classically defined as terminally differentiated, short-lived cells; however, neutrophils can be long-lived with phenotypic plasticity. During inflammation, a subset of neutrophils transdifferentiate into a population called neutrophil-DC hybrids (PMN-DCs) having properties of both neutrophils and dendritic cells. While these cells ubiquitously appear during inflammation, the role of PMN-DCs in disease remains poorly understood. We observed the differentiation of PMN-DCs in pre-clinical murine models of fungal infection: blastomycosis, aspergillosis and candidiasis...
May 21, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29779358/-the-clinical-value-of-diagnostic-driven-therapy-of-invasive-fungal-disease-ifd-type-unclassified-c%C3%A2-group-in-multiple-myeloma-patients-during-inducing-chemotherapy
#2
M L Chen, J Li, B H Huang, J R Liu, L F Kuang, S W Yuan
No abstract text is available yet for this article.
May 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29777151/integrated-proteomics-genomics-metabolomics-approaches-reveal-oxalic-acid-as-pathogenicity-factor-in-tilletia-indica-inciting-karnal-bunt-disease-of-wheat
#3
Vishakha Pandey, Manoj Singh, Dinesh Pandey, Anil Kumar
Tilletia indica incites Karnal bunt (KB) disease in wheat. To date, no KB resistant wheat cultivar could be developed due to non-availability of potential biomarkers related to pathogenicity/virulence for screening of resistant wheat genotypes. The present study was carried out to compare the proteomes of T. indica highly (TiK) and low (TiP) virulent isolates. Twenty one protein spots consistently observed as up-regulated/differential in the TiK proteome were selected for identification by MALDI-TOF/TOF. Identified sequences showed homology with fungal proteins playing essential role in plant infection and pathogen survival, including stress response, adhesion, fungal penetration, invasion, colonization, degradation of host cell wall, signal transduction pathway...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29774383/acute-invasive-fungal-rhinosinusitis-mr-imaging-features-and-their-impact-on-prognosis
#4
Ye Ra Choi, Ji-Hoon Kim, Hye Sook Min, Jae-Kyung Won, Hyun Jik Kim, Roh-Eul Yoo, Koung Mi Kang, Sun-Won Park, Tae Jin Yun, Seung Hong Choi, Chul-Ho Sohn, Jung Hyo Rhim, Soo Chin Kim, Jae Wook Ryu, Dong Gyu Na
PURPOSE: Acute invasive fungal rhinosinusitis (AIFRS) is a life-threatening disease that is difficult to diagnose. Its overall imaging features have not been evaluated and the prognostic impact is unclear. The purpose of our study was to present MR imaging features and their impact on prognosis of AIFRS. METHODS: MR images and clinical records of 23 patients with AIFRS were retrospectively evaluated to identify the imaging features and to determine the factors affecting patients' survival...
May 17, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29770082/first-reported-case-of-multidrug-resistant-candida-auris-in-canada
#5
I S Schwartz, G W Hammond
Candida auris is a fungal pathogen that has recently emerged as a global threat to public health. It was first described in Japan in 2009 and has since been reported in 17 countries on five continents. This case report describes the first reported case of multidrug-resistant C. auris in Canada. In May 2017, a 64-year-old individual was evaluated for chronic otitis externa. Past medical history included a recent hospitalization in India for elective oral surgery that was complicated by an odontogenic brain abscess...
July 6, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29770046/blastomycosis-hospitalizations-in-northwestern-ontario-2006-2015
#6
S Litvinjenko, D Lunny
Background: Blastomycosis, caused by the organism Blastomyces dermatitidis, is an invasive fungal disease found in Central Canada and Central and Midwestern United States. Objective: To describe trends in and epidemiology of hospitalized cases of blastomycosis cases reported among northwestern Ontario residents between 2006 and 2015. Methods: Blastomycosis hospitalization data were extracted from the Discharge Abstract Database (DAD), accessed through IntelliHEALTH Ontario...
October 5, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29768268/antifungal-innate-immunity-a-perspective-from-the-last-10-years
#7
REVIEW
Fabián Salazar, Gordon D Brown
Fungal pathogens can rarely cause diseases in immunocompetent individuals. However, commensal and normally nonpathogenic environmental fungi can cause life-threatening infections in immunocompromised individuals. Over the last few decades, there has been a huge increase in the incidence of invasive opportunistic fungal infections along with a worrying increase in antifungal drug resistance. As a consequence, research focused on understanding the molecular and cellular basis of antifungal immunity has expanded tremendously in the last few years...
May 16, 2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29764946/comparative-genomics-reveals-the-core-gene-toolbox-for-the-fungus-insect-symbiosis
#8
Yan Wang, Matt Stata, Wei Wang, Jason E Stajich, Merlin M White, Jean-Marc Moncalvo
Modern genomics has shed light on many entomopathogenic fungi and expanded our knowledge widely; however, little is known about the genomic features of the insect-commensal fungi. Harpellales are obligate commensals living in the digestive tracts of disease-bearing insects (black flies, midges, and mosquitoes). In this study, we produced and annotated whole-genome sequences of nine Harpellales taxa and conducted the first comparative analyses to infer the genomic diversity within the members of the Harpellales...
May 15, 2018: MBio
https://www.readbyqxmd.com/read/29764228/anti-infective-chemoprophylaxis-after-solid-organ-transplantation
#9
Paul J Deziel, Raymund Razonable
Solid organ transplant recipients are at high risk of opportunistic infections due to bacterial, viral, fungal and parasitic pathogens. Anti-infective prophylaxis is a time-tested proven strategy for the prevention of these infections after solid organ transplantation. Areas covered: The current recommendations for the prevention of surgical site infections, herpes simplex, cytomegalovirus, invasive fungal infections, and selected parasitic diseases are highlighted. Recent peer-reviewed publications on the prevention of infection after solid organ transplantation were reviewed and their significance was discussed in the context of the current recommendations for preventing infectious complications...
May 15, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29760132/a-multimodal-imaging-approach-enables-in-vivo-assessment-of-antifungal-treatment-in-a-mouse-model-of-invasive-pulmonary-aspergillosis
#10
Jennifer Poelmans, Uwe Himmelreich, Liesbeth Vanherp, Luca Zhai, Amy Hillen, Bryan Holvoet, Sarah Belderbos, Matthias Brock, Johan Maertens, Greetje Vande Velde, Katrien Lagrou
Aspergillus fumigatus causes life-threatening lung infections in immunocompromised patients. Mouse models are extensively used in research to assess the in vivo efficacy of antifungals. In recent years, there has been an increasing interest in the use of non-invasive imaging techniques to evaluate experimental infections. However, single imaging modalities have limitations concerning the type of information they can provide. In this study, magnetic resonance imaging and bioluminescence imaging were combined to obtain longitudinal information on the extent of developing lesions and fungal load in a leucopenic mouse model of IPA...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29756722/-use-of-posaconazole-in-children-experience-in-a-tertiary-pediatric-hospital
#11
María T Rosanova, Carla Voto, María S Mussini, Claudia Sarkis, Sandra Gómez, Norma Sberna, Susana Carnovale, Beatriz Caracciolo, Roberto Lede
There is limited information on the use of posaconazole in children. This retrospective and descriptive study was conducted to evaluate the clinical, microbiological characteristics and evolution of patients treated with posaconazole between August 2010 and March 2017. We included 16 children. Median age: 161 months (interquartile range -IQR- 69-173 m). All had underlying disease and a proven invasive fungal infection. The most frequent isolated were Mucor spp. and Aspergillus spp. The mean posaconazole dose was 600 mg/day (400-800 mg/day) and the median duration of treatment was 223 days (IQR 48-632)...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29749387/invasive-candidiasis
#12
REVIEW
Peter G Pappas, Michail S Lionakis, Maiken Cavling Arendrup, Luis Ostrosky-Zeichner, Bart Jan Kullberg
Invasive candidiasis is an important health-care-associated fungal infection that can be caused by several Candida spp.; the most common species is Candida albicans, but the prevalence of these organisms varies considerably depending on geographical location. The spectrum of disease of invasive candidiasis ranges from minimally symptomatic candidaemia to fulminant sepsis with an associated mortality exceeding 70%. Candida spp. are common commensal organisms in the skin and gut microbiota, and disruptions in the cutaneous and gastrointestinal barriers (for example, owing to gastrointestinal perforation) promote invasive disease...
May 11, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29747589/additional-oxidative-stress-reroutes-the-global-response-of-aspergillus-fumigatus-to-iron-depletion
#13
Vivien Kurucz, Thomas Krüger, Károly Antal, Anna-Maria Dietl, Hubertus Haas, István Pócsi, Olaf Kniemeyer, Tamás Emri
BACKGROUND: Aspergillus fumigatus has to cope with a combination of several stress types while colonizing the human body. A functional interplay between these different stress responses can increase the chances of survival for this opportunistic human pathogen during the invasion of its host. In this study, we shed light on how the H2 O2 -induced oxidative stress response depends on the iron available to this filamentous fungus, using transcriptomic analysis, proteomic profiles, and growth assays...
May 10, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29746679/noninfectious-manifestations-and-complications-of-chronic-granulomatous-disease
#14
Sarah E Henrickson, Artemio M Jongco, Kelly F Thomsen, Elizabeth K Garabedian, Isaac P Thomsen
Chronic granulomatous disease (CGD), a primary immunodeficiency characterized by a deficient neutrophil oxidative burst and the inadequate killing of microbes, is well known to cause a significantly increased risk of invasive infection. However, infectious complications are not the sole manifestations of CGD; substantial additional morbidity is driven by noninfectious complications also. These complications can include, for example, a wide range of inflammatory diseases that affect the gastrointestinal tract, lung, skin, and genitourinary tract and overt autoimmune disease...
May 9, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29741690/severe-multisystem-involvement-of-chronic-granulomatous-disease-in-a-pediatric-patient
#15
Zuhal Bayramoglu, Ibrahim Adaletli, Emine Caliskan, Manolya Acar, Selda Hancerli Torun, Ayper Somer
Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder identified by recurrent pyogenic and fungal infections infections secondary to defective nicotinamide adenine dinucleotide phosphate oxidase enzyme. In the present study, we demonstrated a case with a history of multiple segmental lung resections because of invasive bronchopulmonary aspergillosis, multifocal hepatic and splenic granulomas, bilateral adnexal calcific foci presumed to be related with old granulomatous infection and finally gastric outlet obstruction secondary to the involvement of the stomach wall thickening with granulomatous tissue...
May 7, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29737102/-galactomannan-tests-of-bronchoalveolar-lavage-fluid-for-diagnosing-invasive-pulmonary-aspergillosis
#16
Jin Deng, Si-Ying Wu, Ya Liu, Ying Ma, Yi Xie, Zhi-Xing Chen, Zhong-Qiu Dai, Jie-Lun Deng, Mei Kang
OBJECTIVE: To determine the value of galactomannan (GM) in bronchoalveolar lavage fluid (BALF) for diagnosing invasive pulmonary aspergillosis. METHODS: According to the European Organization for Research and Treatment of Cancer / Invasive Fungal Infection Group (EORTC / IFICG) and the American Mycosis Research Group (MSG),and the American College of Infectious Diseases (IDSA) guidelines,295 patients with pulmonary aspergillosis (IPA) and high risk of invasive infections were divided into four groups: IPA group (42 cases),clinically diagnosed group (68 cases),suspected group (61 cases),and non-IPA group (124 cases)...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29731748/oral-bacterial-and-fungal-microbiome-impacts-colorectal-carcinogenesis
#17
REVIEW
Klara Klimesova, Zuzana Jiraskova Zakostelska, Helena Tlaskalova-Hogenova
Host's physiology is significantly influenced by microbiota colonizing the epithelial surfaces. Complex microbial communities contribute to proper mucosal barrier function, immune response, and prevention of pathogen invasion and have many other crucial functions. The oral cavity and large intestine are distant parts of the digestive tract, both heavily colonized by commensal microbiota. Nevertheless, they feature different proportions of major bacterial and fungal phyla, mostly due to distinct epithelial layers organization and different oxygen levels...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29727727/it-takes-a-village-phagocytes-play-a-central-role-in-fungal-immunity
#18
REVIEW
Michael B Feldman, Jatin M Vyas, Michael K Mansour
Phagocytosis is an essential step in the innate immune response to invasive fungal infections. This process is carried out by a proverbial "village" of professional phagocytic cells, which have evolved efficient machinery to recognize and ingest pathogens, namely macrophages, neutrophils and dendritic cells. These innate immune cells drive early cytokine production, fungicidal activity, antigen presentation and activation of the adaptive immune system. Despite the development of antifungal agents with potent activity, the biological activity of professional phagocytic innate immune cells has proven indispensable in protecting a host from invasive fungal infections...
May 1, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29725065/molecular-detection-of-fungal-pathogens-in-clinical-specimens-by-18s-rdna-high-throughput-screening-in-comparison-to-its-pcr-and-culture
#19
K Wagner, B Springer, V P Pires, P M Keller
The rising incidence of invasive fungal infections and the expanding spectrum of fungal pathogens makes early and accurate identification of the causative pathogen a daunting task. Diagnostics using molecular markers enable rapid identification of fungi, offer new insights into infectious disease dynamics, and open new possibilities for infectious disease control and prevention. We performed a retrospective study using clinical specimens (N = 233) from patients with suspected fungal infection previously subjected to culture and/or internal transcribed spacer (ITS) PCR...
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29720997/transposable-element-genomic-fissuring-in-pyrenophora-teres-is-associated-with-genome-expansion-and-dynamics-of-host-pathogen-genetic-interactions
#20
Robert A Syme, Anke Martin, Nathan A Wyatt, Julie A Lawrence, Mariano J Muria-Gonzalez, Timothy L Friesen, Simon R Ellwood
Pyrenophora teres , P. teres f. teres (PTT) and P. teres f. maculata (PTM) cause significant diseases in barley, but little is known about the large-scale genomic differences that may distinguish the two forms. Comprehensive genome assemblies were constructed from long DNA reads, optical and genetic maps. As repeat masking in fungal genomes influences the final gene annotations, an accurate and reproducible pipeline was developed to ensure comparability between isolates. The genomes of the two forms are highly collinear, each composed of 12 chromosomes...
2018: Frontiers in Genetics
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