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https://www.readbyqxmd.com/read/28075008/promising-anti-tumor-properties-of-bisdemethoxycurcumin-a-naturally-occurring-curcumin-analogue
#1
REVIEW
Mahin Ramezani, Mahdi Hatamipour, Amirhosein Sahebkar
Curcuminoids are turmeric-extracted phytochemicals with documented chemopreventive and anti-tumor activities against several types of malignancies. Curcuminoids can modulate several molecular pathways and cellular targets involved in different stages of tumor initiation, growth and metastasis. Bisdemethoxycurcumin (BDMC) is a minor constituent (approximately 3%) of curcuminoids that has been shown to be more stable than the other two main curcuminoids i.e. curcumin and demthoxycurcumin. Recent studies have revealed that BDMC has anti-tumor effects exerted through a multimechanistic mode of action involving inhibition of cell proliferation, invasion and migration, metastasis and tumour growth, and induction of apoptotic death in cancer cells...
January 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28074653/the-essential-medicinal-chemistry-of-curcumin
#2
Kathryn M Nelson, Jayme L Dahlin, Jonathan Bisson, James Graham, Guido F Pauli, Michael A Walters
Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful...
January 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28071969/curcumin-induces-apoptosis-in-human-leukemic-cell-lines-through-an-ifit2-dependent-pathway
#3
Yonglu Zhang, Yunyuan Kong, Shuyuan Liu, Lingbing Zeng, Lagen Wan, Zhanglin Zhang
Curcumin, the primary bioactive component isolated from turmeric, has been shown to possess variety of biological functions including anti-cancer activity. However, molecular mechanisms different cancer cells are various. In the present study, we demonstrated that curcumin induced G2/M cell cycle arrest and apoptosis by increasing the expression levels of cleaved caspase-3, cleaved PARP and decreasing the expression of BCL-2 in U937 human leukemic cells but not in K562 cells. We found some interferon induced genes, especially interferon-induced protein with tetratricopeptide repeats 2 (IFIT2), were significantly up-regulated when treated with curcumin in U937 cells by gene expression chip array, and further confirmed that the expression of IFIT2 was obviously higher in U937 than that in K562 cells by Western blot assay...
January 10, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28070064/rapid-classification-of-turmeric-based-on-dna-fingerprint-by-near-infrared-spectroscopy-combined-with-moving-window-partial-least-squares-discrimination-analysis
#4
Sumaporn Kasemsumran, Nattaporn Suttiwijitpukdee, Vichein Keeratinijakal
In this research, near-infrared (NIR) spectroscopy in combination with moving window partial least squares-discrimination analysis (MWPLS-DA) was utilized to discriminate the variety of turmeric based on DNA markers, which correlated to the quantity of curcuminoid. Curcuminoid was used as a marker compound in variety identification due to the most pharmacological properties of turmeric possessed from it. MWPLS-DA optimized informative NIR spectral regions for the fitting and prediction to {-1/1}-coded turmeric varieties, indicating variables in the development of latent variables in discrimination analysis...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28068085/cyclocurcumin-an-antivasoconstrictive-constituent-of-curcuma-longa-turmeric
#5
Keunyoung Kim, Jung-Jun Kim, Yeryeon Jung, Ji-Yoon Noh, Ahmed Shah Syed, Chul Young Kim, Moo-Yeol Lee, Kyung-Min Lim, Ok-Nam Bae, Jin-Ho Chung
Despite the increasing attention on the therapeutic potential of Curcuma longa (turmeric), the biological activities of curcuminoids other than curcumin are not well understood. Here, we investigated antivasoconstrictive activities of C. longa extract and its ingredients using freshly isolated rat aortic rings. C. longa extract significantly suppressed agonist-stimulated vasoconstriction, and cyclocurcumin was found to be the most potent (IC50 against phenylephrine-induced vasoconstriction: 14.9 ± 1.0 μM) among the 10 tested ingredients including four curcuminoids...
January 9, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28059453/therapeutic-effects-of-curcumin-in-inflammatory-and-immune-mediated-diseases-a-nature-made-jack-of-all-trades
#6
REVIEW
Elham Abdollahi, Amir Abbas Momtazi, Thomas P Johnston, Amirhosein Sahebkar
Curcumin is a dietary polyphenol from turmeric with numerous pharmacological activities. Novel animal and human studies indicate that curcumin can affect different immune cells, such as various T lymphocyte subsets, macrophages, dendritic cells, B lymphocytes and natural killer cells, which results in decreasing severity of various diseases with immunological etiology. The present review provides a comprehensive overview of the effects of curcumin on different immune cells and immune system-related diseases...
January 6, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28054034/sensory-evaluation-of-gluten-free-quinoa-whole-grain-snacks
#7
Talwinder S Kahlon, Roberto J Avena-Bustillos, Mei-Chen M Chiu
Sensory evaluation of quinoa gluten-free whole grain low fat and salt snacks was conducted. The snacks were Quinoa, Quinoa-Cayenne Pepper, Quinoa-Ginger and Quinoa-Turmeric. Cayenne pepper, ginger and turmeric are common spices that contain health promoting nutrients. Cayenne pepper has been associated with enhancing heat production. Ginger has been reported to improve blood flow and prevent joint pains. Turmeric has been observed to have wound healing potential. All the snacks contained 6% corn oil and 2% salt...
December 2016: Heliyon
https://www.readbyqxmd.com/read/28053576/in-vitro-effectiveness-of-curcuma-longa-and-zingiber-officinale-extracts-on-echinococcus-protoscoleces
#8
Esam Almalki, Esam M Al-Shaebi, Saleh Al-Quarishy, Mansour El-Matbouli, Abdel-Azeem S Abdel-Baki
Hydatid disease is an important economic and human public health problem with a wide geographical distribution. Surgical excision remains the primary treatment and the only hope for complete cure of hydatosis. The most important complications arising from surgical excision, however, is recurrence, which is due to dissemination of protoscolices during the surgery. Pre-surgical inactivation of the contents of the hydatid cyst by injection of scolicidal agent into the cyst has been used as adjunct to surgery in order to overcome the risk of recurrence...
January 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28004737/investigating-the-neuroprotective-effects-of-turmeric-extract-structural-interactions-of-%C3%AE-amyloid-peptide-with-single-curcuminoids
#9
Rosario Randino, Manuela Grimaldi, Marco Persico, Augusta De Santis, Elena Cini, Walter Cabri, Antonella Riva, Gerardino D'Errico, Caterina Fattorusso, Anna Maria D'Ursi, Manuela Rodriquez
A broad biophysical analysis was performed to investigate the molecular basis of the neuroprotective action of Curcuma longa extracts in Alzheimer's disease. By combining circular dichroism and electron paramagnetic resonance experiments with molecular modeling calculations, the minor components of Curcuma longa extracts, such as demethoxycurcumin (2, DMC), bisdemethoxycurcumin (3, BDMC) and cyclocurcumin (4, CYC), were analyzed in a membrane environment mimicking the phospholipid bilayer. Our study provides the first evidence on the relative role of single curcuminoids interacting with Aβ-peptide...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27995378/curcumin-a-compound-from-natural-sources-a-true-scientific-challenge-a-review
#10
Zorka Stanić
Curcumin, a plant-derived polyphenolic compound, naturally present in turmeric (Curcuma longa), has been the subject of intensive investigations on account of its various activities. The implementation of safe, beneficial and highly functional compounds from natural sources in human nutrition/prevention/therapy requires some modifications in order to achieve their multi-functionality, improve their bioavailability and delivery strategies, with the main aim to enhance their effectiveness. The low aqueous solubility of curcumin, its rapid metabolism and elimination from the body, and consequently, poor bioavailability, constitute major obstacles to its application...
December 19, 2016: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/27990751/curcumin-improves-glucose-tolerance-via-stimulation-of-glucagon-like-peptide-1-secretion
#11
Masaki Kato, Sho Nishikawa, Akiho Ikehata, Kojiro Dochi, Tsubasa Tani, Tsukasa Takahashi, Atsushi Imaizumi, Takanori Tsuda
SCOPE: Glucagon-like peptide-1 (GLP-1) is a type of incretin secreted from enteroendocrine L-cells. Our previous studies demonstrated that curcumin (a yellow pigment of turmeric) significantly increases the secretion of GLP-1 in enteroendocrine L cell line (GLUTag cells). However, it is not clear whether its action in vivo directly enhances GLP-1 secretion, which then leads to a reduction in blood glucose levels via the stimulation of insulin secretion. In addition, the molecular target of curcumin-induced GLP-1 secretion has not been clarified...
November 7, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27986289/characterisation-of-chemical-components-for-identifying-historical-chinese-textile-dyes-by-ultra-high-performance-liquid-chromatography-photodiode-array-electrospray-ionisation-mass-spectrometer
#12
Jing Han, Jantien Wanrooij, Maarten van Bommel, Anita Quye
This research makes the first attempt to apply Ultra High Performance Liquid Chromatography (UHPLC) coupled to both Photodiode Array detection (PDA) and Electrospray Ionisation Mass Spectrometer (ESI-MS) to the chemical characterisation of common textile dyes in ancient China. Three different extraction methods, respectively involving dimethyl sulfoxide (DMSO)-oxalic acid, DMSO and hydrochloric acid, are unprecedentedly applied together to achieve an in-depth understanding of the chemical composition of these dyes...
January 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27978467/a-highly-selective-nanocomposite-based-on-mip-for-curcumin-trace-levels-quantification-in-food-samples-and-human-plasma-following-optimization-by-central-composite-design
#13
Sonia Bahrani, Mehrorang Ghaedi, Mohammad Javad Khoshnood Mansoorkhani, Abbas Ostovan
A selective and rapid method was developed for quantification of curcumin in human plasma and food samples using molecularly imprinted magnetic multiwalled carbon nanotubes (MMWCNTs) which was characterized with EDX and FESEM. The role of sorbent mass, volume of eluent and sonication time on response in solid phase microextraction procedure were optimized by central composite design (CCD) combined with response surface methodology (RSM) using Statistica. Preliminary experiments reveal that among different solvents, methanol:dimethyl sulfoxide (4:1V/V) led to efficient and quantitative elution of analyte...
January 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27976174/turmeric-based-beverage-blunted-acute-high-fat-meal-induced-oxidative-stress-by-lowering-serum-malondialdehyde-mda-levels-a-randomized-cross-over-study
#14
Y C Zanzer, Â G Batista, I Björck, E Östman
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27976097/%C3%AE-secretase-inhibitors-from-sesame-seeds-and-turmeric-rhizomes
#15
K Murata, S Matsumura, Y Yoshioka, N Zaima, M Morimoto, H Matsuda
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27966512/evaluating-the-efficacy-of-denture-cleansing-materials-in-removal-of-tea-and-turmeric-stains-an-in-vitro-study
#16
Priyanka P Makhija, Kamal Shigli, Vaibhav Awinashe
CONTEXT: Extrinsic staining of acrylic resin dentures could be a major esthetic problem for denture wearers. Tea, coffee, cola, turmeric, and tobacco often cause extrinsic staining of dentures. AIM: To evaluate the efficacy of various denture cleansing materials in the removal of tea and turmeric stains and to compare the efficacy of those denture cleansers with each other in the removal of tea and turmeric stains. MATERIALS AND METHODS: Heat-cured acrylic resin specimens were stained using tea and turmeric solutions...
September 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/27956904/antibacterial-action-of-curcumin-against-staphylococcus-aureus-a-brief-review
#17
REVIEW
Sin-Yeang Teow, Kitson Liew, Syed A Ali, Alan Soo-Beng Khoo, Suat-Cheng Peh
Curcumin, the major constituent of Curcuma longa L. (Zingiberaceae family) or turmeric, commonly used for cooking in Asian cuisine, is known to possess a broad range of pharmacological properties at relatively nontoxic doses. Curcumin is found to be effective against Staphylococcus aureus (S. aureus). As demonstrated by in vitro experiment, curcumin exerts even more potent effects when used in combination with various other antibacterial agents. Hence, curcumin which is a natural product derived from plant is believed to have profound medicinal benefits and could be potentially developed into a naturally derived antibiotic in the future...
2016: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27956075/natural-product-htp-screening-for-attenuation-of-cytokine-induced-neutrophil-chemo-attractants-cincs-and-no2-in-lps-ifn%C3%AE-activated-glioma-cells
#18
Elizabeth A Mazzio, David Bauer, Patricia Mendonca, Equar Taka, Karam F A Soliman
Chronic and acute central nervous system (CNS) inflammation are contributors toward neurological injury associated with head trauma, stroke, infection, Parkinsons or Alzheimers disease. CNS inflammatory illnesses can also contribute toward risk of developing glioblastoma multiforme (GBM). With growing public interest in complementary and alternative medicines (CAMs), we conduct a high throughput (HTP) screening of >1400 natural herbs, plants and over the counter (OTC) products for anti-inflammatory effects on lipopolysaccharide (LPS)/interferon gamma (IFNγ) activated C6 glioma cells...
January 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27930973/phytosomal-curcumin-a-review-of-pharmacokinetic-experimental-and-clinical-studies
#19
REVIEW
Hamed Mirzaei, Abolfazl Shakeri, Bahman Rashidi, Amin Jalili, Zarrin Banikazemi, Amirhossein Sahebkar
Curcumin, a hydrophobic polyphenol, is the principal constituent extracted from dried rhizomes of Curcuma longa L. (turmeric). Curcumin is known as a strong anti-oxidant and anti-inflammatory agent that has different pharmacological effects. In addition, several studies have demonstrated that curcumin is safe even at dosages as high as 8g per day; however, instability at physiological pH, low solubility in water and rapid metabolism results in a low oral bioavailability of curcumin. The phytosomal formulation of curcumin (a complex of curcumin with phosphatidylcholine) has been shown to improve curcumin bioavailability...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27928704/antioxidant-effects-of-curcuminoids-in-patients-with-type-2-diabetes-mellitus-a-randomized-controlled-trial
#20
Yunes Panahi, Nahid Khalili, Ebrahim Sahebi, Soha Namazi, Maryam Saberi Karimian, Muhammed Majeed, Amirhossein Sahebkar
BACKGROUND: Oxidative stress has a key role in the pathogenesis of type II diabetes mellitus (T2DM) and its vascular complications. Antioxidant therapy has been suggested as a potential approach to blunt T2DM development and progression. The aim of this study was to assess the effects of supplementation with curcuminoids, which are natural polyphenolics from turmeric, on oxidative indices in diabetic individuals. METHODS: In this randomized double-blind placebo-controlled trial, 118 subjects with T2DM were randomized to curcuminoids (1000 mg/day co-administered with piperine 10 mg/day) or matching placebo for a period of 8 weeks...
December 7, 2016: Inflammopharmacology
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