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https://www.readbyqxmd.com/read/28918484/drug-herb-interactions-in-the-elderly-patient-with-ibd-a-growing-concern
#1
REVIEW
Haider Rahman, Marina Kim, Galen Leung, Jesse A Green, Seymour Katz
Inflammatory bowel disease (IBD), which includes conditions such as Crohn's disease and ulcerative colitis, is becoming more prevalent with the elderly being the fastest growing group. Parallel to this, there is an increasing interest in the use of complementary and alternative medicine (CAM). Nearly half of patients with IBD have used CAM at one time. The elderly patients, however, are burdened by comorbid conditions, polypharmacy, and altered functional status. With increasing use of complementary and alternative medicine in our elderly patients with IBD, it is vital for the provider to provide counsel on drug-herb potential interactions...
September 16, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28914481/boron-and-nitrogen-co-doped-carbon-dots-as-a-sensitive-fluorescent-probe-for-the-detection-of-curcumin
#2
Wei Bian, Xuan Wang, Yakun Wang, Haifen Yang, Jialin Huang, Zongwei Cai, Martin M F Choi
In this present study, a fluorescent probe was developed to detect curcumin, which is derived from the rhizomes of the turmeric. We used a simple and economical way to synthesize boron and nitrogen co-doped carbon dots (BNCDs) by microwave heating. The maximum emission wavelength of the BNCDs was 450 nm at an excitation wavelength of 360 nm. The as-prepared BNCDs were characterized by multiple analytical techniques such as transmission electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, and infrared spectroscopy...
September 15, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28911688/curcumin-inhibits-adenosine-deaminase-and-arginase-activities-in-cadmium-induced-renal-toxicity-in-rat-kidney
#3
Ayodele Jacob Akinyemi, Nora Onyebueke, Opeyemi Ayodeji Faboya, Sunday Amos Onikanni, Adewale Fadaka, Israel Olayide
In this study, the effect of enzymes involved in degradation of renal adenosine and l-arginine was investigated in rats exposed to cadmium (Cd) and treated with curcumin, the principal active phytochemical in turmeric rhizome. Animals were divided into six groups (n = 6): saline/vehicle, saline/curcumin 12.5 mg/kg, saline/curcumin 25 mg/kg, Cd/vehicle, Cd/curcumin 12.5 mg/kg, and Cd/curcumin 25 mg/kg. The results of this study revealed that the activities of renal adenosine deaminase and arginase were significantly increased in Cd-treated rats when compared with the control (p < 0...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28904007/synthetic-analogs-of-curcumin-modulate-the-function-of-multidrug-resistance-linked-abc-transporter-abcg2
#4
Megumi Murakami, Shinobu Ohnuma, Michihiro Fukuda, Eduardo E Chufan, Katsuyoshi Kudoh, Keigo Kanehara, Norihiko Sugisawa, Masaharu Ishida, Takeshi Naitoh, Hiroyuki Shibata, Yoshiharu Iwabuchi, Suresh V Ambudkar, Michiaki Unno
Multidrug resistance (MDR) caused by the overexpression of ATP-binding cassette (ABC) transporters in cancer cells is a major obstacle in cancer chemotherapy. Previous studies have shown that curcumin, a natural product and a dietary constituent of turmeric, inhibits the function of MDR-related ABC transporters, including ABCB1, ABCC1, and especially ABCG2. However, the limited bioavailability of curcumin prevents its use for modulation of the function of these transporters in the clinical setting. In this study, we investigated the effects of twenty-four synthetic curcumin analogs with increased bioavailability on the transport function of ABCG2...
September 13, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28899500/calebin-a-a-novel-component-of-turmeric-suppresses-nf-%C3%AE%C2%BAb-regulated-cell-survival-and-inflammatory-gene-products-leading-to-inhibition-of-cell-growth-and-chemosensitization
#5
Amit K Tyagi, Sahdeo Prasad, Muhammed Majeed, Bharat B Aggarwal
BACKGROUND: While the anti-inflammatory and anticancer potential of curcumin, which is derived from turmeric (Curcuma longa), has been studied extensively, very little is known about Calebin A, another novel compound from the same source. PURPOSE: To determine whether Calebin A exhibits anti-inflammatory and anticancer potential. METHODS: We examined the anti-inflammatory potential of Calebin A by DNA binding of NF-κB. Anticancer properties of Calebin were determined by MTT and FACS analysis and NF-κB regulated expression of proteins was assessed by western blotting...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28889732/effects-of-water-extract-of-curcuma-longa-l-roots-on-immunity-and-telomerase-function
#6
Min-Hsiung Pan, Jia-Ching Wu, Chi-Tang Ho, Vladimir Badmaev
Background Immunity and Longevity Methods A water extract of Curcuma longa (L.) [vern. Turmeric] roots (TurmericImmune™) standardized for a minimum 20 % of turmeric polysaccharides ukonan A, B, C and D was evaluated for its biological properties in in vitro tissue culture studies. Results The water extract of turmeric (TurP) exhibited induced-nitric oxide (NO) production in RAW264.7 macrophages. These results suggested the immunomodulatory effects of TurP. In addition, the polysaccharides up-regulated function of telomerase reverse transcriptase (TERT) equally to the phenolic compound from turmeric, curcumin...
May 12, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28887965/preparation-characterization-and-anti-colitis-activity-of-curcumin-asafoetida-complex-encapsulated-in-turmeric-nanofiber
#7
Sreeraj Gopi, Augustine Amalraj, Shintu Jude, Karthik Varma, T R Sreeraj, Józef T Haponiuk, Sabu Thomas
Ulcerative colitis (UC) is a main form of inflammatory bowel disease (IBD). Asafoetida (ASF) and turmeric have traditionally been used for the treatment of various inflammatory diseases, including UC, because ASF is rich in sulfur compounds and turmeric contains curcumin (CUR). Turmeric nanofiber (TNF), the modified cell wall component of turmeric is considered to play important role in the human diet, health and can be used as a carrier agent to encapsulate bioactive components. A novel gut health product (GHP) was formulated by encapsulation of ASF and CUR complex onto TNF...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28884496/potential-role-of-curcumin-against-biofilm-producing-organisms-on-the-skin-a-review
#8
REVIEW
Alexandra R Vaughn, Kelly N Haas, Waqas Burney, Erich Andersen, Ashley K Clark, Robert Crawford, Raja K Sivamani
Turmeric root (Curcuma longa) is predominantly used as a spice, but has also long been known to possess antimicrobial, analgesic, antiinflammatory, and anticancer properties. One predominant group of active compounds in turmeric are curcuminoids, namely bright yellow-pigmented curcumin. While modern science has yet to fully investigate the therapeutic claims of turmeric and its derivatives, results have proven promising in decreasing pain and inflammation in arthritis, improving insulin sensitivity in diabetes, and even curing a variety of infections...
September 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28880711/curcumin-alleviates-the-functional-gastrointestinal-disorders-of-mice-in-vivo
#9
Jing Yu, Wen-Hua Xu, Wei Sun, Yi Sun, Zhi-Li Guo, Xiao-Ling Yu
Curcumin is a natural polyphenol extracted from the turmeric rhizome, which has a wide range of biological activities, but until now the effects of curcumin on the gastrointestinal peristalsis have not been fully understood. In vivo study, we observed the effects of curcumin on gastric emptying and intestinal propulsion rates of mice in normal state and in delayed state by atropine (ATR) or nitric oxide precursor L-arginine (L-Arg). An in vitro study explored the direct effects of curcumin on the intestinal contractility, but were studied through measuring spontaneous contraction of isolated jejunum of mice...
September 7, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28875835/the-biological-potentialsof-indian-traditional-medicine-curcumin-for-treating-human-diseases
#10
C S Sumathi
Curcumin is an active compound extracted from the rhizomes of Curcuma longa L. (Turmeric). It possesses a di phenolic structure and there are three important fractions of curcumin namely curcumin, mono-desmethoxycurcumin and bis-desmethoxycurcumin. Curcumin is having high medicinal value. It is widely in Ayurveda, Siddha and Unani medicine formulations to treat various diseases. It is effective against microbial pathogens like bacteria, virus and fungi. It is highly potent and kills cancerous cells. Curcumin exhibits antioxidant activity and reduces lipoperoxidation...
August 30, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28873765/greek-pdo-saffron-authentication-studies-using-species-specific-molecular-markers
#11
I Bosmali, S A Ordoudi, M Z Tsimidou, P Madesis
Saffron, the spice produced from the red stigmas of the flower of Crocus sativus L. is a frequent target of fraud and mislabeling practices that cannot be fully traced using the ISO 3632 trade standard specifications and test methods. A molecular approach is proposed herein as a promising branding strategy for the authentication of highly esteemed saffron brands such as the Greek Protected Designation of Origin (PDO) "Krokos Kozanis". Specific ISSR (inter-simple sequence repeat) markers were used to assess for the first time, the within species variability of several populations of C...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28870897/phosphoproteomic-analysis-identifies-signaling-pathways-regulated-by-curcumin-in-human-colon-cancer-cells
#12
Tatsuhiro Sato, Yutaka Higuchi, Yoshio Shibagaki, Seisuke Hattori
BACKGROUND: Curcumin, a major polyphenol of the spice turmeric, acts as a potent chemopreventive and chemotherapeutic agent in several cancer types, including colon cancer. Although various proteins have been shown to be affected by curcumin, how curcumin exerts its anticancer activity is not fully understood. MATERIALS AND METHODS: Phosphoproteomic analyses were performed using SW480 and SW620 human colon cancer cells to identify curcumin-affected signaling pathways...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28869111/enhancement-of-sperm-motility-and-viability-by-turmeric-by-product-dietary-supplementation-in-roosters
#13
Wenjing Yan, Chihiro Kanno, Eiki Oshima, Yukiko Kuzuma, Sung Woo Kim, Hanako Bai, Masashi Takahashi, Yojiro Yanagawa, Masashi Nagano, Jun-Ichi Wakamatsu, Manabu Kawahara
Improving sperm motility and viability are major goals to improve efficiency in the poultry industry. In this study, the effects of supplemental dietary turmeric by-product (TBP) from commercial turmeric production on sperm motility, viability, and antioxidative status were examined in domestic fowl. Mature Rhode Island Red roosters were divided into two groups - controls (groupC) without TBP administration and test subjects (groupT) fed a basal diet supplemented with 0.8g of TBP/day in a temperature-controlled rearing facility (Experiment 1) and 1...
October 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28860764/liposomal-curcumin-and-its-application-in-cancer
#14
REVIEW
Ting Feng, Yumeng Wei, Robert J Lee, Ling Zhao
Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28858834/curcumin-synthesis-optimization-and-in-silico-interaction-with-cyclin-dependent-kinase
#15
Mahmood Ahmed, Muhammad Abdul Qadir, Muhammad Imtiaz Shafiq, Muhammad Muddassar, Abdul Hameed, Muhammad Nadeem Arshad, Abdullah M Asiri
Curcumin is a natural product with enormous biological potential. In this study, curcumin synthesis was revisited using different reaction solvents, a catalyst (n-butylamine) and a water scavenger [(n-BuO)3B], to develop the optimal procedure for its rapid acquisition. During synthesis, solvent choice was found to be an important parameter for better curcumin yield and high purity. In a typical reaction, acetyl acetone was treated with boron trioxide, followed by condensation with vanillin in the presence of tri-n-butyl borate as water scavenger and n-butylamine as catalyst at 80 °C in ethyl acetate to afford curcumin...
September 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28853916/vascular-endothelial-growth-factor-an-important-molecular-target-of-curcumin
#16
Maryam Saberi-Karimian, Niki Katsiki, Michele Caraglia, Mariarosaria Boccellino, Muhammed Majeed, Amirhossein Sahebkar
The discovery of Vascular Endothelial Growth Factor (VEGF), the key modulator of angiogenesis, has triggered intensive research on anti-angiogenic therapeutic modalities. Although several clinical studies have validated anti-VEGF therapeutics, with few of them approved by the U.S. Food and Drug Administration (FDA), anti-angiogenic therapy is still in its infancy. Phytochemicals are compounds that have several metabolic and health benefits. Curcumin, the yellow pigment derived from turmeric (Curcuma longa L...
August 30, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28852643/concealed-use-of-herbal-and-dietary-supplements-among-thai-patients-with-type-2-diabetes-mellitus
#17
Prapaipan Putthapiban, Weera Sukhumthammarat, Chutintorn Sriphrapradang
BACKGROUND: Diabetes mellitus (DM) has been one of the most common chronic diseases that create great impacts on both morbidities and mortalities. Many patients who suffering from this disease seek for complementary and alternative medicine. The aim of this study was to determine the prevalence and related factors of herbal and dietary supplement (HDS) use in patients with DM type 2 at a single university hospital in Thailand. METHODS: A cross-sectional study was performed in 200 type 2 DM patients via face-to-face structured interviews using developed questionnaires comprised of demographic data, diabetes-specific information, details on HDS use, and medical adherence...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28837227/enrichment-and-cytotoxic-activity-of-curcuminoids-from-turmeric-using-macroporous-resins
#18
Cheng Chen, Shuna Jin, Xingliang Xiang, Xuanyuan Wang, Qingxin Shi, Min Yang, Simin Ji, Rongzeng Huang, Chengwu Song
Curcuminoids are functional secondary metabolites abundant in turmeric. In the present study, a simple and efficient method for enrichment of curcuminoids from turmeric was developed using macroporous resin. Eight different types of macroporous resins were examined by static adsorption/desorption properties and the type of XDA-7 was selected as the optimum one. Under the optimized conditions, the final contents of refined extract excluded 84.2% of impurities, by comparison with crude extract in a scale-up experiment...
August 24, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28833603/metformin-incombination-with-curcumin-inhibits-the-growth-metastasis-and-angiogenesis-of-hepatocellular-carcinoma-in-vitro-and-in-vivo
#19
Hui-Hui Zhang, Ying Zhang, Yan-Na Cheng, Fu-Lian Gong, Zhan-Qi Cao, Lu-Gang Yu, Xiu-Li Guo
Hepatocellular carcinoma (HCC) has poor prognosis due to the advanced disease stages by the time it is diagnosed, high recurrence rates and metastasis. In the present study, we investigated the effects of metformin (a safe anti-diabetic drug) and curcumin (a turmeric polyphenol extracted from rhizome of Curcuma longa Linn.) on proliferation, apoptosis, invasion, metastasis and angiogenesis of HCC in vitro and in vivo. It was found that co-treatment of metformin and curcumin could not only induce tumor cells into apoptosis through activating the mitochondria pathways, but also suppress the invasion, metastasis of HCC cells and angiogenesis of HUVECs...
August 19, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28814952/regulative-effects-of-curcumin-spice-administration-on-gut-microbiota-and-its-pharmacological-implications
#20
Liang Shen, Lu Liu, Hong-Fang Ji
Curcumin, the major active component of turmeric (Curcuma longa), is widely used as a spice and food-coloring agent, and also exhibits multiple biological activities. However, as curcumin has poor systemic bioavailability its pharmacology remains to be elucidated. Owing to the high concentration of curcumin in the gastrointestinal tract after oral administration, we hypothesize that it may exert regulative effects on the gut microbiota. We investigated the regulative effects of oral curcumin administration on the gut microbiota of C57BL/6 mice and found that curcumin significantly affected the abundance of several representative families in gut microbial communities, including Prevotellaceae, Bacteroidaceae, and Rikenellaceae...
2017: Food & Nutrition Research
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