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https://www.readbyqxmd.com/read/28634862/effect-of-gapt-extract-on-expression-of-tau-protein-and-its-phosphorylation-related-enzymes-in-hippocampal-neurons-of-appv717i-transgenic-mice
#1
Jing-Nian Ni, Jing Shi, Xue-Kai Zhang, Yi-Chang Yang, Xiao-Meng Liu, Ming-Qing Wei, Ting Li, Peng-Wen Wang, Jin-Zhou Tian, Yong-Yan Wang
OBJECTIVE: To investigate the effect of GAPT, an extract mixture from Radix Ginseng, Rhizoma Acor tatarinowii, Radix Polygalae and Radix Curcuma (containing ingredient of turmeric), etc. on expression of tau protein and its phosphorylation related enzyme in hippocampal neurons of APPV717I transgenic mice. METHODS: Sixty three-month-old APPV717I transgenic mice were randomly divided into model group, donepezil group [0.92 mg/(kg d)], the low, medium and high dosage of GAPT groups [0...
June 20, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28628644/targeting-multiple-pro-apoptotic-signaling-pathways-with-curcumin-in-prostate-cancer-cells
#2
Mariela Rivera, Yanilda Ramos, Madeline Rodríguez-Valentín, Sheila López-Acevedo, Luis A Cubano, Jin Zou, Qiang Zhang, Guangdi Wang, Nawal M Boukli
Curcumin, an extract from the turmeric rhizome (Curcuma longa), is known to exhibit anti-inflammatory, antioxidant, chemopreventive and antitumoral activities against aggressive and recurrent cancers. Accumulative data indicate that curcumin may induce cancer cell death. However, the detailed mechanism underlying its pro-apoptotic and anti-cancer effects remains to be elucidated. In the present study, we examined the signaling pathways triggered by curcumin, specifically, the exact molecular mechanisms of curcumin-induced apoptosis in highly metastatic human prostate cancer cells...
2017: PloS One
https://www.readbyqxmd.com/read/28627598/curcumin-exerts-its-tumor-suppressive-function-via-inhibition-of-nedd4-oncoprotein-in-glioma-cancer-cells
#3
Xue Wang, Jiaojiao Deng, Jinxia Yuan, Xin Tang, Yuelong Wang, Haifeng Chen, Yi Liu, Liangxue Zhou
Glioblastoma is the most common brain cancer in adults. It represents one of the top ten malignant tumors with an average survival time of nine months despite treatments with surgery, radiotherapy and chemotherapy. Curcumin is a phytochemical turmeric isolated from root of the Curcuma longa plant. Accumulating evidence have proved that curcumin targets numerous cancer signaling pathways. The E3 ubiquitin ligase NEDD4, neural precursor cell expressed developmentally downregulated protein 4, is frequently overexpressed in various cancers...
June 8, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28621274/evaluation-to-prevent-the-physical-changes-in-colored-elastomeric-modules-when-exposed-to-various-dietary-media
#4
S Dhivya Kanya, K Pradeep Babu, R Venkatesan, A Nanda Kumar
AIM AND OBJECTIVE: The aim of the study is to analyze and compare the variation of lumen size and thickness of the elastomeric colored modules when immersed in four selected dietary media. MATERIALS AND METHODS: Sample size of 40 modules on each color - such as red, blue, green, and black - was taken and immersed in four dietary media (artificial saliva, coke mixed with artificial saliva, turmeric mixed with artificial saliva, and coffee mixed with artificial saliva)...
June 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28620478/a-hot-water-extract-of-turmeric-curcuma-longa-suppresses-acute-ethanol-induced-liver-injury-in-mice-by-inhibiting-hepatic-oxidative-stress-and-inflammatory-cytokine-production
#5
Ryusei Uchio, Yohei Higashi, Yusuke Kohama, Kengo Kawasaki, Takashi Hirao, Koutarou Muroyama, Shinji Murosaki
Turmeric (Curcuma longa) is a widely used spice that has various biological effects, and aqueous extracts of turmeric exhibit potent antioxidant activity and anti-inflammatory activity. Bisacurone, a component of turmeric extract, is known to have similar effects. Oxidative stress and inflammatory cytokines play an important role in ethanol-induced liver injury. This study was performed to evaluate the influence of a hot water extract of C. longa (WEC) or bisacurone on acute ethanol-induced liver injury. C57BL/6 mice were orally administered WEC (20 mg/kg body weight; BW) or bisacurone (60 µg/kg BW) at 30 min before a single dose of ethanol was given by oral administration (3·0 g/kg BW)...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28611316/effects-of-resveratrol-curcumin-berberine-and-other-nutraceuticals-on-aging-cancer-development-cancer-stem-cells-and-micrornas
#6
James A McCubrey, Kvin Lertpiriyapong, Linda S Steelman, Steve L Abrams, Li V Yang, Ramiro M Murata, Pedro L Rosalen, Aurora Scalisi, Luca M Neri, Lucio Cocco, Stefano Ratti, Alberto M Martelli, Piotr Laidler, Joanna Dulińska-Litewka, Dariusz Rakus, Agnieszka Gizak, Paolo Lombardi, Ferdinando Nicoletti, Saverio Candido, Massimo Libra, Giuseppe Montalto, Melchiorre Cervello
Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and other health-enhancing effects. A key target of the effects of natural products may be the regulation of microRNA (miR) expression which results in cell death or prevents aging, diabetes, cardiovascular and other diseases. This review will focus on a few natural products, especially on resveratrol (RES), curcumin (CUR) and berberine (BBR). RES is obtained from the skins of grapes and other fruits and berries. RES may extend human lifespan by activating the sirtuins and SIRT1 molecules...
June 12, 2017: Aging
https://www.readbyqxmd.com/read/28608236/the-neuroprotective-effect-of-curcumin-against-nicotine-induced-neurotoxicity-is-mediated-by-creb-bdnf-signaling-pathway
#7
Majid Motaghinejad, Manijeh Motevalian, Sulail Fatima, Fahimeh Faraji, Shiva Mozaffari
Nicotine abuse adversely affects brain and causes apoptotic neurodegeneration. Curcumin- a bright yellow chemical compound found in turmeric is associated with neuroprotective properties. The current study was designed to evaluate the role of CREB-BDNF signaling in mediating the neuroprotective effects of curcumin against nicotine-induced apoptosis, oxidative stress and inflammation in rats. Sixty adult male rats were divided randomly into six groups. Group 1 received 0.7 ml/rat normal saline, group 2 received 6 mg/kg nicotine...
June 12, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28605325/turmeric-bioprocessed-with-mycelia-from-the-shiitake-culinary-medicinal-mushroom-lentinus-edodes-agaricomycetes-protects-mice-against-salmonellosis
#8
Sung Phil Kim, Sang Jong Lee, Seok Hyun Nam, Mendel Friedman
This study investigated the suppressive mechanisms of an extract from bioprocessed Lentinus edodes mycelial liquid culture supplemented with turmeric (bioprocessed Curcuma longa extract [BPCLE]) against murine salmonellosis. The BPLCE extract from the bioprocessed mycelia of the Salmonella Typhimurium into murine RAW 264.7 macrophage cells, elimination of intracellular bacteria, and elevation of inducible nitric oxide synthase expression. Dietary administration of BPCLE activated leukocytes from the mice infected with Salmonella through the intraperitoneal route...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28599484/anticancer-effect-of-curcumin-inhibits-cell-growth-through-mir-21-pten-akt-pathway-in-breast-cancer-cell
#9
Xinzheng Wang, Yakai Hang, Jinbiao Liu, Yongqiang Hou, Ning Wang, Mingjun Wang
Curcumin is a polyphenol extracted from turmeric, which that belongs to the Zingiberaceae family. Curcumin has numerous effects, including anti-inflammatory, antitumor, anti-oxidative and antimicrobial effects. However, the effects of curcumin on human breast cancer cells remain largely unknown. The aim of the present study was to investigate the anticancer effects and the mechanisms by which curcumin affects breast cancer cells. The anticancer effect of curcumin on cell viability and cytotoxicity on human breast cancer MCF-7 cells was analyzed using 3-(4,5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide and lactate dehydrogenase assays, respectively...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28595926/curcumin-induces-autophagic-cell-death-in-spodoptera-frugiperda-cells
#10
Sethuraman Veeran, Benshui Shu, Gaofeng Cui, Shengjiao Fu, Guohua Zhong
The increasing interest in the role of autophagy (type II cell death) in the regulation of insect toxicology has propelled study of investigating autophagic cell death pathways. Turmeric, the rhizome of the herb Curcuma longa (Mañjaḷ in Tamil, India and Jiānghuáng in Chinese) have been traditionally used for the pest control either alone or combination with other botanical pesticides. However, the mechanisms by which Curcuma longa or curcumin exerts cytotoxicity in pests are not well understood. In this study, we investigated the potency of Curcuma longa (curcumin) as a natural pesticide employing Sf9 insect line...
June 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28579781/investigating-the-use-of-curcumin-loaded-electrospun-filaments-for-soft-tissue-repair-applications
#11
Pierre-Alexis Mouthuy, Maja Somogyi Škoc, Ana Čipak Gašparović, Lidija Milković, Andrew J Carr, Neven Žarković
Electrospun filaments represent a new generation of medical textiles with promising applications in soft tissue repair. A potential strategy to improve their design is to combine them with bioactive molecules. Curcumin, a natural compound found in turmeric, is particularly attractive for its antioxidant, anti-inflammatory, and antimicrobial properties. However, investigating the range of relevant doses of curcumin in materials designed for tissue regeneration has remained limited. In this paper, a wide range of curcumin concentrations was explored and the potential of the resulting materials for soft tissue repair applications was assessed...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28579298/regulation-of-gsk-3-activity-by-curcumin-berberine-and-resveratrol-potential-effects-on-multiple-diseases
#12
REVIEW
James A McCubrey, Kvin Lertpiriyapong, Linda S Steelman, Steve L Abrams, Lucio Cocco, Stefano Ratti, Alberto M Martelli, Saverio Candido, Massimo Libra, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus
Natural products or nutraceuticals promote anti-aging, anti-cancer and other health-enhancing effects. A key target of the effects of natural products may be the regulation of the PI3K/PTEN/Akt/mTORC1/GSK-3 pathway. This review will focus on the effects of curcumin (CUR), berberine (BBR) and resveratrol (RES), on the PI3K/PTEN/Akt/mTORC1/GSK-3 pathway, with a special focus on GSK-3. These natural products may regulate the pathway by multiple mechanisms including: reactive oxygen species (ROS), cytokine receptors, mirco-RNAs (miRs) and many others...
May 26, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/28575990/effects-of-curcumin-loaded-plga-nanoparticles-on-the-rg2-rat-glioma-model
#13
Merdan Orunoğlu, Abbas Kaffashi, Sibel Bozdağ Pehlivan, Selma Şahin, Figen Söylemezoğlu, Kader Karli Oğuz, Melike Mut
BACKGROUND: Curcumin, the active ingredient of turmeric, has a remarkable antitumor activity against various cancers, including glioblastoma. However, it has poor absorption and low bioavailability; thus, to cross the blood-brain barrier and reach tumor tissue, it needs to be transferred to tumor site by special drug delivery systems, such as nanoparticles. OBJECTIVE: We aimed to evaluate the antitumor activity of curcumin on glioblastoma tissue in the rat glioma-2 (RG2) tumor model when it is loaded on poly(lactic-co-glycolic acid)-1,2-distearoyl-glycerol-3-phospho-ethanolamine-N-[methoxy (polyethylene glycol)-2000] ammonium salt (PLGA-DSPE-PEG) hybrid nanoparticles...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28571271/evaluation-of-efficacy-of-1-curcuminoids-as-local-application-in-management-of-oral-lichen-planus-interventional-study
#14
Anju Elizabeth Thomas, Beena Varma, Seema Kurup, Renju Jose, Marina Lazar Chandy, Sreeja P Kumar, M S Aravind, Athira Aruna Ramadas
INTRODUCTION: Oral Lichen Planus (OLP) is a chronic inflammatory mucocutaneous disease affecting the oral cavity which has been associated with severe burning sensation which in turn affects the quality of life of the patients. Currently, the effective treatment of choice remains the use of corticosteroids. The chronicity and recalcitrant nature of the disease demand the long term use of these drugs with ensuing adverse effects. Turmeric and its active ingredient, "curcumin", have been found to have anti-inflammatory, antioxidant and anticancer properties...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28569571/curcumin-inhibits-oxidative-stress-induced-trpm2-channel-activation-calcium-ion-entry-and-apoptosis-values-in-sh-sy5y-neuroblastoma-cells-involvement-of-transfection-procedure
#15
Ahmi Öz, Ömer Çelik
Transient Receptor Potential (TRP) channels are mostly Ca(2+) permeable cation channels. Transient Receptor Potential Melastatin-like 2 (TRPM2) is expressed in neurological tissues such as brain, dorsal root ganglia (DRG) neurons, hippocampus and also liver, heart and kidney. The SH-SY5Y cells are mostly used as a cellular model of neurodegenerative diseases, Alzheimer's and Parkinson's diseases. Curcumin, shows phenolic structure, synthesized by Curcuma longa L. (turmeric), has powerful non-enzymatically antioxidant effects compared with Vitamin E...
June 1, 2017: Molecular Membrane Biology
https://www.readbyqxmd.com/read/28567044/curcumin-promotes-the-clearance-of-listeria-monocytogenes-both-in-vitro-and-in-vivo-by-reducing-listeriolysin-o-oligomers
#16
Xuan Zhou, Bing Zhang, Yumei Cui, Shuiye Chen, Zihao Teng, Gejin Lu, Jianfeng Wang, Xuming Deng
The pore-forming toxin listeriolysin O (LLO), an essential virulence factor that is secreted by Listeria monocytogenes (L. monocytogenes), is responsible for bacterial breaching at the phagosomal membranes and subsequent release into the cytoplasm; it cannot be recognized by the host immune system. The vital role that LLO plays in bacterial pathogenicity and evading host immune clearance makes this virulence a promising target for addressing L. monocytogenes infection. In this study, we hypothesized that curcumin, a polyphenol derived from turmeric that could effectively inhibit LLO pore-forming activity, might be useful in the prevention or treatment of L...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28561324/curcumin-ameliorates-kidney-function-and-oxidative-stress-in-experimental-chronic-kidney-disease
#17
Badreldin H Ali, Suhail Al-Salam, Yousuf Al Suleimani, Jamila Al Kalbani, Shadia Al Bahlani, Mohammed Ashique, Priyadarsini Manoj, Buthaina Al Zhili, Nadia Al Abri, Heba T Naser, Javed Yasin, Abderrahim Nemmar, Mohamed Al Za'abi, Christina Hartmann, Nicole Schupp
Chronic kidney disease (CKD) is known to involve inflammation, oxidative stress and apoptosis. Here, we investigated the impact of curcumin (diferuloyl methane, a phenolic turmeric pigment), which has strong anti-oxidant, anti-inflammatory and anti-apoptotic activities on kidney structure and function in rats with adenine-induced CKD. Rats were treated for 5 weeks with adenine to induce CKD-like renal damage and combined with three doses of curcumin. Markers of kidney function and oxidative stress were quantified in plasma, urine, renal homogenates and on kidney tissue...
May 31, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28551901/-the-role-of-the-plant-artemisia-in-survival-and-induction-of-apoptosis-of-b-cells-in-chronic-lymphocytic-leukemia-cll
#18
Vita Mirkin, Alain Berrebi, Igor Rakhman, Michal Haran, Lev Shvidel
BACKGROUND: The cytotoxic effect of plants such as green tea and turmeric (curcumin) on B chronic lymphocytic leukemia (CLL) cells has been established. The plant Artemisia has been used in China for anti-cancer and anti-malaria applications. In Israel, Artemisia absinthium ("the Chiba") is used to release abdominal pain. In attempts to evaluate the cytotoxic effect of this plant in CLL cells, we prepared a decoction of Artemisia leaves and after filtration used it as an inducer of apoptosis of B CLL cells...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28548854/curcumin-protects-membranes-through-carpet-or-insertion-model-depending-on-hydration
#19
Richard J Alsop, Alexander Dhaliwal, Maikel C Rheinstadter
Curcumin is the main ingredient of turmeric, a common Indian spice. Curcumin shows a broad spectrum of effects, including anti-Alzheimer's and anti-oxidant properties. An interaction between curcumin and lipid membranes has been speculated as the root-cause, and the molecule is often proposed to `protect' the bilayer. However, the detailed molecular mechanism of this protection is disputed. There is evidence that curcumin either a) lies flat on the bilayer and provides a `carpet' for protection by forming a steric barrier, or b) inserts into the membrane and stiffens tails, thereby protecting against peptide insertion...
May 26, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28546962/recent-advances-of-curcumin-in-the-prevention-and-treatment-of-renal-fibrosis
#20
REVIEW
Xuejiao Sun, Yi Liu, Cheng Li, Xiting Wang, Ruyuan Zhu, Chenyue Liu, Haixia Liu, Lili Wang, Rufeng Ma, Min Fu, Dongwei Zhang, Yu Li
Curcumin, a polyphenol derived from the turmeric, has received attention as a potential treatment for renal fibrosis primarily because it is a relatively safe and inexpensive compound that contributes to kidney health. Here, we review the literatures on the applications of curcumin in resolving renal fibrosis in animal models and summarize the mechanisms of curcumin and its analogs (C66 and (1E,4E)-1,5-bis(2-bromophenyl) penta-1,4-dien-3-one(B06)) in preventing inflammatory molecules release and reducing the deposition of extracellular matrix at the priming and activation stage of renal fibrosis in animal models by consulting PubMed and Cnki databases over the past 15 years...
2017: BioMed Research International
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