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pancreatitis amikacin

T Spencer Poore, Isabel Virella-Lowell, Jennifer S Guimbellot
PRESENTATION: Patient is a 6-year-old male with CF, MRSA colonization, and pancreatic insufficiency that presented with worsening ppFEV1 and systemic symptoms despite multiple interventions. BAL grew NTM, Stenotrophomonas maltophilia, and Inquilinus limosus, a rare organism found in patients with CF. COURSE: I. limosus treatment was deferred. Despite treatment of other pathogens, symptoms worsened. I. limosus was targeted with meropenem, amikacin, and ciprofloxacin along with clindamycin for MRSA colonization...
May 23, 2018: Pediatric Pulmonology
Tao Teng, Liguo Liang, Kai Chen, Bingwen Xi, Jun Xie, Pao Xu
The morphology and the drug sensitivity of the strain GYX2014-1 isolated from the hepatic pancreatic tissue of moribund Litopenaeus vannamei were evaluated by conventional culture characteristics, physical and chemical characteristics, and molecular biology methods. Detection of extracellulase and hemolysin activity shows that the isolated GYX2014-1 has protease, lipase, gelatinase activity, but none of amylase, or lecithinase activity. The 16S rRNA gene (GenBank accession number: KT781675) was analyzed, and a phylogenetic tree analysis showed that the isolated pathogen was most closely related to V...
2017: PloS One
Jun-Feng Zhang, Hong-Yan Zhu, Yong-Wei Sun, Wei Liu, Yan-Miao Huo, De-Jun Liu, Jiao Li, Rong Hua
BACKGROUND: Pseudomonas aeruginosa (P. aeruginosa) is a leading cause of nosocomial infections, which is difficult to treat because of limited susceptibility to antimicrobial agents. In China, isolation rates of P. aeruginosa were observed to increase by year. The incidence of infectious complications after pancreatoduodenectomy (PD) were high. However, there was no data available regarding P. aeruginosa infection in patients undergoing PD. This study evaluated the risk factors and clinical impacts of P...
December 2015: Surgical Infections
Aleksandra Lisowska, Andrzej Pogorzelski, Grzegorz Oracz, Katarzyna Siuda, Wojciech Skorupa, Marta Rachel, Szczepan Cofta, Tomasz Piorunek, Jarosław Walkowiak
BACKGROUND: The aim of the present study was to assess the influence of antibiotic therapy on fat assimilation in cystic fibrosis (CF) patients with small intestine bacterial overgrowth (SIBO). MATERIALS AND METHODS: Twenty six pancreatic insufficient CF patients with bronchopulmonary exacerbation and diagnosed SIBO (positive hydrogen-methane breath test) entered the study. (13)C mixed triglyceride breath test was performed before and after antibiotic therapy. Sixteen subjects were treated intravenously (ceftazidime and amikacin), ten patients orally (ciprofloxacin)...
December 2011: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Aleksandra Lisowska, Andrzej Pogorzelski, Grzegorz Oracz, Wojciech Skorupa, Szczepan Cofta, Jarosław Szydłowski, Jerzy Socha, Jarosław Walkowiak
Antibiotic therapy in the cystic fibrosis (CF) mouse model has been shown to result in reduced bacterial load of the intestine and significant body mass gain. The effect was suggested to be linked to the improvement of intestinal digestion and absorption. Therefore, we aimed to assess the influence of routinely applied antibiotic therapy in CF patients on fat assimilation. Twenty-four CF patients aged 6 to 30 years entered the study. Inclusion criteria comprised confirmed exocrine pancreatic insufficiency and bronchopulmonary exacerbation demanding antibiotic therapy...
2011: Acta Biochimica Polonica
Andrew M Jones, Jennifer M Helm
There are a number of potential drugs for the treatment of cystic fibrosis (CF) currently undergoing clinical studies. A number of antibacterials formulated for delivery by inhalation are at various stages of study; these include dry-powder inhaler versions of colistin, tobramycin and ciprofloxacin, and formulations of azteonam, amikacin, levofloxacin, ciprofloxacin and fosfomycin/tobramycin for nebulization. Clinical trials of anti-inflammatory agents, including glutathione, phosphodiesterase-5 inhibitors such as sildenafil, oral acetylcysteine, simvastatin, methotrexate, docosahexaenoic acid, hydroxychloroquine, pioglitazone and alpha1-antitrypsin, are ongoing...
October 1, 2009: Drugs
Yoshito Takeuchi, Haruumi Okabe, Satoshi Myojo, Sotaro Fujimoto
We describe a mediastinal pancreatic pseudocyst treated with a catheter drainage placed under computed tomographic guidance using a newly applied approach. A needle was angled cephalad with the computed tomographic gantry tilt technique, and was inserted into the lowest portion of the cavity through the liver and through the diaphragm. The needle pathway was necessitated by the location of the pseudocyst cavity. The drainage alleviated completely the symptoms with no complications. The puncture technique should be an option for accessing mediastinal lesions percutaneously...
January 2002: Hepato-gastroenterology
J S Cho, Y J Choi, D K Chung
Endoglucanase A from Clostridium thermocellum resistant to pancreatic proteinase was selected out of a range of microbial cellulases expressed in lactobacilli. Two Lactobacillus-E. coli expression vectors, harboring the endoglucanase gene from C. thermocellum under the control of its own promoter (pSD1) and the Lactococcus lactis lac A promoter (pSD2), were constructed separately. Intestinal Lactobacillus strains, L. gasseri and L. johnsonii, were electrotransformed with pSD1 and pSD2, and the stability of each plasmid was evaluated...
April 2000: Current Microbiology
C H Yang, C K Wang
Edwardsiella tarda (E. tarda) has recently become recognized as a pathogen in humans. Here we report a new case of E. tarda bacteraemia complicated by acute pancreatitis and pyomyoma. A 46-year-old female came to our emergency room complaining of sudden onset of left upper quadrant pain and vomiting for the previous few hours after drinking three bottles of wine. An abdominal computed tomography (CT) scan revealed multiple biliary stones, acute pancreatitis with extensive inflammatory change, and a large uterine myoma...
March 1999: Journal of Infection
K M Kramer, H Levy
Death from acute severe pancreatitis results from infection and multiple organ system failure occurring late in the course of illness. Patients with necrotizing pancreatitis involving at least one-third of the organ are at highest risk of secondary infection and death. We conducted a MEDLINE search to identify human trials of prophylactic antibiotics in acute pancreatitis. Results of early studies of prophylactic ampicillin to avoid secondary infection and death were negative, but the studies included patients with mild disease who are at low risk for infection...
May 1999: Pharmacotherapy
J Spicák, J Martínek, F Závada, J Morávek, V Melenovsky
BACKGROUND: Penetration of antibiotics into the pancreas is considered to be an important criterion in determining the most appropriate antibiotic treatment during severe acute pancreatitis. Our study investigated pancreatic penetration of five antibiotics in rats with and without acute necrotizing pancreatitis (ANP) (non-pancreatitis rats (NR), pancreatitis rats (AP)). METHODS: ANP was induced by intraductal bile acid injection, and 3 h later the antibiotic was administered...
January 1999: Scandinavian Journal of Gastroenterology
G F Hu
A class of angiogenesis inhibitor has emerged from our mechanistic study of the action of angiogenin, a potent angiogenic factor. Neomycin, an aminoglycoside antibiotic, inhibits nuclear translocation of human angiogenin in human endothelial cells, an essential step for angiogenin-induced angiogenesis. The phospholipase C-inhibiting activity of neomycin appears to be involved, because U-73122, another phospholipase C inhibitor, has a similar effect. In contrast, genistein, oxophenylarsine, and staurosporine, inhibitors of tyrosine kinase, phosphotyrosine phosphatase, and protein kinase C, respectively, do not inhibit nuclear translocation of angiogenin...
August 18, 1998: Proceedings of the National Academy of Sciences of the United States of America
A Hostacká, E Karelová
Postantibiotic effects were induced in three Pseudomonas aeruginosa strains after short-term treatment (30 min) with amikacin at suprainhibitory concentrations in the range of 0.6-1.2 h (2 x MIC) and of 3.0-4.4 h (4 x MIC). Significant suppression of P. aeruginosa elastase activity was found after treatment with amikacin at 4 x MIC concentration (to 10-69.2% of the control values); 2 x MIC was less effective. The profile of outer membrane proteins of P. aeruginosa was not changed after treatment with amikacin at both concentrations...
March 1997: Chemotherapy
R Delcenserie, T Yzet, J P Ducroix
Infectious complications currently account for 80% of deaths from acute pancreatitis. The aim of this study was to evaluate the necessity for prophylactic antibiotics in patients with severe acute pancreatitis. Twenty-three consecutive patients suffering from acute alcoholic pancreatitis with computed tomography demonstrating two or more fluid collections were randomly assigned to one of two groups receiving either nonantibiotic treatment or prophylactic antibiotics (ceftazidime, amikacine, and metronidazole for 10 days)...
August 1996: Pancreas
C Bassi, P Pederzoli, S Vesentini, M Falconi, A Bonora, H Abbas, A Benini, E M Bertazzoni
The aim of the study was to verify whether antibiotics excreted by the normal pancreas are also excreted in human necrotizing pancreatitis, reaching the tissue sites of the infection. Twelve patients suffering from acute necrotizing pancreatitis were treated with imipenem-cilastatin (0.5 g), mezlocillin (2 g), gentamicin (0.08 g), amikacin (0.5 g), pefloxacin (0.4 g), and metronidazole (0.5 g). Serum and necrotic samples were collected simultaneously at different time intervals after parenteral drug administration by computed tomography-guided needle aspiration, intraoperatively, and from surgical drainages placed during surgery...
April 1994: Antimicrobial Agents and Chemotherapy
L Gianotti, R Munda, R Gennari, R Pyles, J W Alexander
OBJECTIVE: To assess the effect of four regimens of antibiotics (compared with a control regimen of distilled water) given orally on gut decontamination, bacterial translocation, and mortality in acute necrotising pancreatitis in mice. DESIGN: Randomised experimental study. SETTING: University hospitals, USA and Italy. MATERIALS: 150 young Swiss Webster mice. INTERVENTION: All mice were fed a diet deficient in choline and supplemented with ethionine...
February 1995: European Journal of Surgery, Acta Chirurgica
Y G Lee
1. Serum, peripheral and thoracic lymph concentrations of tobramycin, dibekacin and amikacin were determined at various time intervals up to 6 hours following intramuscular administration of 4 mg/kg to dogs. Peak serum concentrations of each antibacterial agents occurred within one hour after administration. The peak lymphatic concentrations occurred in 1.5 approximately 2 hours after administration. Following peak peripheral lymph concentration, the concentration in peripheral lymph exceeded than that of serum...
May 1980: Japanese Journal of Antibiotics
J R Wallace, J Johnson, C E Lucas, R Cushing, A M Ledgerwood, C Sugawa
Pancreatic ductal penetration of antibiotics is not uniform. Antibiotic therapy for pancreatic and pancreatic related infections, theoretically, is enhanced by drugs that reach the ductal system. The pancreatic ductal penetrance of Cefamandol (1 gm), Amikacin (7.5 mg/kg), and Chloramphenicol (1 gm) given as a single intravenous dose prior to endoscopic retrograde cholangiopancreatography was studied in ten patients. Serum and pancreatic juice were collected simultaneously, frozen, and later assayed for antibiotic concentration...
December 1984: American Surgeon
P R Meylan, T Calandra, P A Casey, M P Glauser
Sixty-four severe infections in hospitalized patients were treated with intravenous Timentin. Most patients (mean age: 50.5 years, range 18-85) had serious underlying conditions such as agranulocytosis, heart failure, cancer, diabetes mellitus, chronic alcoholism or other functional or anatomical abnormalities. Forty-three episodes were bacteriologically proved, and bacteraemia was diagnosed in 18. The sites of infection were: lower respiratory tract (10), upper respiratory tract (10), soft tissues (9), urinary tract (7), bones (6), peritoneal cavity (3), meninges (1) and pelvis (1)...
May 1986: Journal of Antimicrobial Chemotherapy
B Meier, U Metzger, F Müller, W Siegenthaler, R Lüthy
A retroperitoneal Nocardia asteroides abscess was diagnosed in a 76-year-old patient. Trimethoprimsulfamethoxazole treatment for 6.5 weeks failed after surgical drainage of the abscess, and superinfection occurred. Subsequent treatment with amikacin resulted in a cure after 7 weeks. Amikacin might significantly shorten the duration of treatment in disseminated nocardiosis.
January 1986: Antimicrobial Agents and Chemotherapy
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