keyword
MENU ▼
Read by QxMD icon Read
search

gut microbiota,

keyword
https://www.readbyqxmd.com/read/28329766/complex-pectin-metabolism-by-gut-bacteria-reveals-novel-catalytic-functions
#1
Didier Ndeh, Artur Rogowski, Alan Cartmell, Ana S Luis, Arnaud Baslé, Joseph Gray, Immacolata Venditto, Jonathon Briggs, Xiaoyang Zhang, Aurore Labourel, Nicolas Terrapon, Fanny Buffetto, Sergey Nepogodiev, Yao Xiao, Robert A Field, Yanping Zhu, Malcolm A O'Neill, Breeanna R Urbanowicz, William S York, Gideon J Davies, D Wade Abbott, Marie-Christine Ralet, Eric C Martens, Bernard Henrissat, Harry J Gilbert
The metabolism of carbohydrate polymers drives microbial diversity in the human gut microbiota. It is unclear, however, whether bacterial consortia or single organisms are required to depolymerize highly complex glycans. Here we show that the gut bacterium Bacteroides thetaiotaomicron uses the most structurally complex glycan known: the plant pectic polysaccharide rhamnogalacturonan-II, cleaving all but 1 of its 21 distinct glycosidic linkages. The deconstruction of rhamnogalacturonan-II side chains and backbone are coordinated to overcome steric constraints, and the degradation involves previously undiscovered enzyme families and catalytic activities...
March 22, 2017: Nature
https://www.readbyqxmd.com/read/28328990/gut-microbiome-analysis-of-type-2-diabetic-patients-from-the-chinese-minority-ethnic-groups-the-uygurs-and-kazaks
#2
Ye Wang, Xin Luo, Xinmin Mao, Yicun Tao, Xinjian Ran, Haixia Zhao, Jianhui Xiong, Linlin Li
The gut microbiome may have an important influence on the development of diabetes mellitus type 2 (DM2). To better understand the DM2 pandemic in ethnic minority groups in China, we investigated and compared the composition and richness of the gut microbiota of healthy, normal glucose tolerant (NGT) individuals and DM2 patients from two ethnic minority groups in Xinjiang, northwest China, the Uygurs and Kazaks. The conserved V6 region of the 16S rRNA gene was amplified by PCR from the isolated DNA. The amplified DNA was sequenced and analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28328981/dysbiosis-and-compositional-alterations-with-aging-in-the-gut-microbiota-of-patients-with-heart-failure
#3
Takehiro Kamo, Hiroshi Akazawa, Wataru Suda, Akiko Saga-Kamo, Yu Shimizu, Hiroki Yagi, Qing Liu, Seitaro Nomura, Atsuhiko T Naito, Norifumi Takeda, Mutsuo Harada, Haruhiro Toko, Hidetoshi Kumagai, Yuichi Ikeda, Eiki Takimoto, Jun-Ichi Suzuki, Kenya Honda, Hidetoshi Morita, Masahira Hattori, Issei Komuro
Emerging evidence has suggested a potential impact of gut microbiota on the pathophysiology of heart failure (HF). However, it is still unknown whether HF is associated with dysbiosis in gut microbiota. We investigated the composition of gut microbiota in patients with HF to elucidate whether gut microbial dysbiosis is associated with HF. We performed 16S ribosomal RNA gene sequencing of fecal samples obtained from 12 HF patients and 12 age-matched healthy control (HC) subjects, and analyzed the differences in gut microbiota...
2017: PloS One
https://www.readbyqxmd.com/read/28328896/microbiota-and-reproducibility-of-rodent-models
#4
REVIEW
Craig L Franklin, Aaron C Ericsson
The gut microbiota (GM) plays a critical role in human health and disease. Likewise, it is becoming increasingly evident that changes or disruptions to the GM can have significant effects on animal models and their expressed phenotypes, adding a complex and important variable into basic research and preclinical studies. In this article, we review some of the most common sources of GM variability in rodent models, and discuss measures to address this variability for improved reproducibility.
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328083/oral-iron-supplementation-potential-implications-for-the-gut-microbiome-and-metabolome-in-patients-with-ckd
#5
Guus A M Kortman, Dorien Reijnders, Dorine W Swinkels
Patients with chronic kidney disease (CKD) and loss of kidney function are at increased risk for morbidity and mortality. The risks of CKD are attributed to "uremia," an increased concentration of uremic retention solutes (toxins) in the plasma. Recently, a colo-renal axis became clearly apparent and uremia has been associated with an altered gut microbiome composition and metabolism. There is a high prevalence of anemia in patients with CKD, for which patients are often treated with oral or intravenous iron...
March 22, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28326446/blastocystis-how-do-specific-diets-and-human-gut-microbiota-affect-its-development-and-pathogenicity
#6
REVIEW
M Lepczyńska, J Białkowska, E Dzika, K Piskorz-Ogórek, J Korycińska
Blastocystis is an enteric parasite that inhabits the gastrointestinal tract of humans and many animals. This emerging parasite has a worldwide distribution. It is often identified as the most common eukaryotic organism reported in human fecal samples. This parasite is recognized and diagnosed more often than ever before. Furthermore, some strains develop resistance against currently recommended drugs, such as metronidazole; therefore, the use of natural remedies or special diets has many positive aspects that may address this problem...
March 22, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28325929/gut-microbiota-neonatal-gut-microbiota-induces-lung-immunity-against-pneumonia
#7
Sabrina Tamburini, Jose C Clemente
No abstract text is available yet for this article.
March 22, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28325732/whey-protein-effects-on-energy-balance-link-the-intestinal-mechanisms-of-energy-absorption-with-adiposity-and-hypothalamic-neuropeptide-gene-expression
#8
Kanishka N Nilaweera, Raul Cabrera-Rubio, John R Speakman, Paula M O' Connor, AnneMarie McAuliffe, Caitriona M Guinane, Elaine Lawton, Fiona Crispie, Mònica Aguilera, Maurice Stanley, Serena Boscaini, Susan Joyce, Silvia Melgar, John F Cryan, Paul D Cotter
We tested the hypothesis that dietary whey protein isolate (WPI) affects the intestinal mechanisms related to energy absorption and that the resulting energy deficit is compensated by changes in energy balance to support growth. C57BL/6 mice were provided a diet enriched with WPI with varied sucrose content, and the impact on energy balance related parameters were investigated. As part of a high sucrose diet, WPI reduced the hypothalamic expression of pro-opiomelanocortin gene expression and increased energy intake...
March 21, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28324102/duodenal-mucosa-of-patients-with-type-1-diabetes-shows-distinctive-inflammatory-profile-and-microbiota
#9
Silvia Pellegrini, Valeria Sordi, Andrea Mario Bolla, Diego Saita, Roberto Ferrarese, Filippo Canducci, Massimo Clementi, Francesca Invernizzi, Alberto Mariani, Riccardo Bonfanti, Graziano Barera, Pier Alberto Testoni, Claudio Doglioni, Emanuele Bosi, Lorenzo Piemonti
Context: Increasing evidences suggest a correlation between gut and type 1 diabetes (T1D). Objective: The objective of this study is to evaluate the gut inflammatory profile and microbiota in patients with T1D, compared to healthy controls (CTRL) and patients with celiac disease (CD) as gut inflammatory disease controls. Design/Setting/Participants: The inflammatory status and microbiome composition were evaluated in biopsies of the duodenal mucosa of patients with T1D (n=19), CD (n=19) and CTRL (n=16), recruited at San Raffaele Scientific Institute, in Milan, Italy, between 2009 and 2015...
January 19, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323391/metagenomic-analysis-reveals-changes-of-the-drosophila-suzukii-microbiota-in-the-newly-colonised-regions
#10
Isabel Martinez-Sañudo, Mauro Simonato, Andrea Squartini, Nicola Mori, Laura Marri, Luca Mazzon
The spotted wing drosophila, Drosophila suzukii (Matsumura) (Diptera: Drosophilidae) is a highly polyphagous pest of a wide variety of wild or cultivated berry and stone fruit. Originating from Southeast Asia, it has recently invaded a wide range of regions in Europe and North-America. It is well known that insect microbiotas may significantly influence several aspects of the host biology and play an important role in invasive species introduction into new areas. However, in spite of the great economic importance of D...
March 21, 2017: Insect Science
https://www.readbyqxmd.com/read/28323133/the-effect-of-penicillin-administration-in-early-life-on-murine-gut-microbiota-and-blood-lymphocyte-subsets
#11
Jaroslaw Daniluk, Urszula Daniluk, Malgorzata Rusak, Milena Dabrowska, Joanna Reszec, Magdalena Garbowicz, Kinga Humińska, Andrzej Dabrowski
BACKGROUND AND AIM: Antibiotics have many beneficial effects but their uncontrolled use may lead to increased risk of serious diseases in the future. Our hypothesis is that an early antibiotic exposition may affect immune system by altering gut microbiota. Therefore, the aim of the study was to determine the effect of penicillin treatment on gut microorganisms and immune system of mice. METHODS: 21-days old C57BL6/J/cmdb male mice were treated with low-dose of penicillin (study group) or water only (control group) for 4 weeks...
March 16, 2017: Anaerobe
https://www.readbyqxmd.com/read/28322790/short-chain-fatty-acids-gpr41-and-gpr43-ligands-inhibit-tnf-%C3%AE-induced-mcp-1-expression-by-modulating-p38-and-jnk-signaling-pathways-in-human-renal-cortical-epithelial-cells
#12
Mamiko Kobayashi, Daisuke Mikami, Hideki Kimura, Kazuko Kamiyama, Yukie Morikawa, Seiji Yokoi, Kenji Kasuno, Naoki Takahashi, Takanobu Taniguchi, Masayuki Iwano
Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, are produced predominantly by gut microbiota fermentation of dietary fiber. SCFAs are newly identified as endogenous ligands of two orphan G protein-coupled receptors, GPR41 and GPR43, which have the potential to modulate inflammation. Therefore, GPR41 and GPR43 may mediate the link between the gut microbiome status and various disease conditions including renal inflammation. This study aimed at investigating whether SCFAs activate GPR41 and GPR43, and thereby exert anti-inflammatory effects in human renal cortical epithelial cells (HRCEs) as a main component of kidney tissue...
March 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28322745/role-of-the-small-intestine-colon-and-microbiota-in-determining-the-metabolic-fate-of-polyphenols
#13
REVIEW
Gary Williamson, Michael N Clifford
(Poly)phenols are a large group of compounds, found in food, beverages, dietary supplements and herbal medicines. Owing to their biological activities, absorption and metabolism of the most abundant compounds in humans are well understood. Both the chemical structure of the phenolic moiety and any attached chemical groups define whether the polyphenol is absorbed in the small intestine, or reaches the colon and is subject to extensive catabolism by colonic microbiota. Untransformed substrates may be absorbed, appearing in plasma primarily as methylated, sulfated and glucuronidated derivatives, with in some cases the unchanged substrate...
March 16, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28321827/effects-of-dietary-administration-of-shewanella-xiamenensis-a-1-aeromonas-veronii-a-7-and-bacillus-subtilis-single-or-combined-on-the-grass-carp-ctenopharyngodon-idella-intestinal-microbiota
#14
Kai Hao, Zhuo-Qi Wu, Dong-Liang Li, Xiao-Bo Yu, Gao-Xue Wang, Fei Ling
Gut microbiota of grass carp plays an important role in host. However, detailed information regarding the changes of microbiota after probiotics administration in relation to the gastrointestinal microbiota is absent. In the present study, dietary administration of putative probiotics Shewanella xiamenensis A-1, Aeromonas veronii A-7, and Bacillus subtilisstrains was conducted in grass carp to investigate if there is a discernible alteration in intestinal microbiota and whether the alteration is associated with previous study about the immunity regulation in grass carp...
March 21, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28321508/gut-microbiota-and-bacterial-translocation-in-digestive-surgery-the-impact-of-probiotics
#15
REVIEW
Shunichiro Komatsu, Yukihiro Yokoyama, Masato Nagino
PURPOSE: It is conceivable that manipulation of the gut microbiota could reduce the incidence or magnitude of surgical complications in digestive surgery. However, the evidence remains inconclusive, although much effort has been devoted to randomized controlled trials (RCTs) and meta-analyses on probiotics. Furthermore, the mechanism behind the protective effects of probiotics appears elusive, our understanding of probiotic actions being fragmentary. The objective of this review is to assess the clinical relevance of the perioperative use of probiotics in major digestive surgery, based on a comprehensive view of the gut microbiota, bacterial translocation (BT), and host defense system...
March 20, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28321211/first-foods-and-gut-microbes
#16
Martin F Laursen, Martin I Bahl, Kim F Michaelsen, Tine R Licht
The establishment of the human gut microbiota in early life has been associated with later health and disease. During the 1st months after birth, the microbial composition in the gut is known to be affected by the mode of delivery, use of antibiotics, geographical location and type of feeding (breast/formula). Consequently, the neonatal period and early infancy has attracted much attention. However, after this first period the gut microbial composition continues to develop until the age of 3 years, and these 1st years have been designated "a window of opportunity" for microbial modulation...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28321050/alteration-of-gut-microbial-community-after-n-n-dimethylformamide-exposure
#17
Man Zhang, Min Zheng, Zhijun Wu, Mingyue Guan, Shuai Liu, Wenjin Zhao, Juan Cheng
N,N-Dimethylformamide (DMF), a solvent commonly used in factories, can induce liver toxicities, including hepatitis, fibrosis, cirrhosis and hepatoma. It is well known that the gut microbial community plays a role in the metabolism of many toxic substance and in liver regeneration. However, the effect of DMF on rat gut microbial community is poorly understood. The gut microbiotas in control rats and rats exposed to DMF were characterized by high-throughput sequencing of the bacterial 16S rRNA gene. The levels of biochemical parameters in the serum of rats, including cholesterol, bile acid, alanine aminotransferase (ALT), and aspartate aminotransferase (AST), were evaluated...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28320888/mutual-reinforcement-of-pathophysiological-host-microbe-interactions-in-intestinal-stasis-models
#18
Ketrija Touw, Daina L Ringus, Nathaniel Hubert, Yunwei Wang, Vanessa A Leone, Anuradha Nadimpalli, Betty R Theriault, Yong E Huang, Johnathan D Tune, Paul B Herring, Gianrico Farrugia, Purna C Kashyap, Dionysios A Antonopoulos, Eugene B Chang
Chronic diseases arise when there is mutual reinforcement of pathophysiological processes that cause an aberrant steady state. Such a sequence of events may underlie chronic constipation, which has been associated with dysbiosis of the gut. In this study we hypothesized that assemblage of microbial communities, directed by slow gastrointestinal transit, affects host function in a way that reinforces constipation and further maintains selection on microbial communities. In our study, we used two models - an opioid-induced constipation model in mice, and a humanized mouse model where germ-free mice were colonized with stool from a patient with constipation-predominant irritable bowel syndrome (IBS-C) in humans...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28320307/perturbation-of-microbiota-in-one-day-old-broiler-chickens-with-antibiotic-for-24-hours-negatively-affects-intestinal-immune-development
#19
Dirkjan Schokker, Alfons J M Jansman, Gosse Veninga, Naomi de Bruin, Stephanie A Vastenhouw, Freddy M de Bree, Alex Bossers, Johanna M J Rebel, Mari A Smits
BACKGROUND: Gut microbial colonization and development of immune competence are intertwined and are influenced by early-life nutritional, environmental, and management factors. Perturbation of the gut microbiome at young age affects the crosstalk between intestinal bacteria and host cells of the intestinal mucosa. RESULTS: We investigated the effect of a perturbation of the normal early life microbial colonization of the jejunum in 1-day old chickens. Perturbation was induced by administering 0...
March 20, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28320221/rice-or-pork-based-diets-with-similar-calorie-and-content-result-in-different-rat-gut-microbiota
#20
Xiaozhe Qi, Wentao Xu, Mingzhang Guo, Siyuan Chen, Yifei Liu, Xiaoyun He, Kunlun Huang
Rice is the most important food crop, and pork is the most widely eaten meat in the world. In this study, we compared the gut microbiota of the rats fed with rice or pork mixed diets, which have similar caloric contents. The physiological indices (body weights, hematology, serum chemistry, organ weights and histopathology) of two groups were all within the normal range. Two diets did not induce difference in the diversity of gut bacteria. However, Firmicutes were significantly higher in rice diet group, while Bacteroidetes were enriched in pork diet group...
March 20, 2017: International Journal of Food Sciences and Nutrition
keyword
keyword
107626
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"