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https://www.readbyqxmd.com/read/29040999/hepatic-function-during-repeated-tace-procedures-and-prognosis-after-introducing-sorafenib-in-patients-with-unresectable-hepatocellular-carcinoma-multicenter-analysis
#1
Atsushi Hiraoka, Takashi Kumada, Masatoshi Kudo, Masashi Hirooka, Yohei Koizumi, Yoichi Hiasa, Kazuto Tajiri, Hidenori Toyoda, Toshifumi Tada, Hironori Ochi, Koji Joko, Noritomo Shimada, Akihiro Deguchi, Toru Ishikawa, Michitaka Imai, Kunihiko Tsuji, Kojiro Michitaka
BACKGROUND/AIM: We evaluated the relationship of hepatic function with repeated transarterial catheter chemoembolization (TACE) and prognosis after sorafenib treatment in various patient cohorts. METHODS: Study 1 comprised of 212 Barcelona clinic liver cancer stage-B (BCLC-B) HCC patients classified as Child-Pugh A (CP-A) and who had received repeated TACE treatments (r-TACE) (naïve:recurrence = 66:146). Study 2 comprised of 435 patients with unresectable HCC classified as CP-A in who sorafenib was introduced (naïve:recurrence = 37:398; CP score 5:6 = 282:153; macro-vessel invasion [MVI]+: extrahepatic metastasis [EHM]+ both negative = 124:226:143)...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040993/hemodynamic-changes-on-cone-beam-computed-tomography-during-balloon-occluded-transcatheter-arterial-chemoembolization-using-miriplatin-for-hepatocellular-carcinoma-a-preliminary-study
#2
Toru Ishikawa, Michitaka Imai, Takashi Owaki, Hiroki Sato, Yujiro Nozawa, Tomoe Sano, Akito Iwanaga, Keiichi Seki, Terasu Honma, Toshiaki Yoshida, Masatoshi Kudo
BACKGROUND/AIM: Balloon-occluded transcatheter arterial chemoembolization (B-TACE) using miriplatin (MPT) is anticipated as a new strategy for hepatocellular carcinoma (HCC). This study was aimed at evaluating the hemodynamic changes with/without balloon occlusion of the hepatic artery, correlation of cone-beam CT (CBCT) pixels, and CT value after B-TACE for HCC. METHODS: A total of 52 patients with HCC, who underwent B-TACE using MPT in addition to the balloon-occluded CBCT hepatic arteriography, were studied...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040990/non-hypervascular-hypointense-hepatic-nodules-during-the-hepatobiliary-phase-of-gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic-acid-enhanced-mri-as-a-risk-factor-of-intrahepatic-distant-recurrence-after-radiofrequency-ablation-of-hepatocellular-carcinoma
#3
Takayuki Iwamoto, Yasuharu Imai, Takumi Igura, Sachiyo Kogita, Yoshiyuki Sawai, Kazuto Fukuda, Yoshitaka Yamaguchi, Yasushi Matsumoto, Masanori Nakahara, Osakuni Morimoto, Hiroshi Ohashi, Norihiko Fujita, Masatoshi Kudo, Tetsuo Takehara
BACKGROUND: Non-hypervascular hypointense hepatic nodules during the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI have been reported to be associated with intrahepatic distant recurrence (IDR) after hepatectomy or radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). IDR is categorized into hypervascular transformation of non-hypervascular hypointense hepatic nodules and new intrahepatic recurrence. The aim of this study was to evaluate the relationship between non-hypervascular hypointense hepatic nodules on Gd-EOB-DTPA-enhanced MRI and IDR after RFA, focusing on new intrahepatic recurrence...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040989/hepatocellular-carcinoma-after-achievement-of-sustained-viral-response-with-daclatasvir-and-asunaprevir-in-patients-with-chronic-hepatitis-c-virus-infection
#4
Hiroshi Ida, Satoru Hagiwara, Masashi Kono, Tomohiro Minami, Hirokazu Chishina, Tadaaki Arizumi, Masahiro Takita, Norihisa Yada, Yasunori Minami, Kazuomi Ueshima, Naoshi Nishida, Masatoshi Kudo
BACKGROUND: Interferon-based antiviral therapies against hepatitis C virus (HCV) infection have been shown to reduce the incidence of hepatocellular carcinoma (HCC) in patients with sustained viral response (SVR). Recently, direct-acting antivirals (DAAs) have been proven to be much more effective in achieving SVR than interferon-based therapies. However, whether DAAs can efficiently prevent the occurrence of HCC after SVR remains controversial. To clarify this issue, we analyzed the clinical features of patients in whom HCC developed after achievement of SVR with DAAs for chronic HCV infection...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040988/unique-characteristics-associated-with-sustained-liver-damage-in-chronic-hepatitis-c-patients-treated-with-direct-acting-antivirals
#5
Masashi Kono, Naoshi Nishida, Satoru Hagiwara, Tomohiro Minami, Hirokazu Chishina, Tadaaki Arizumi, Kosuke Minaga, Ken Kamata, Yoriaki Komeda, Toshiharu Sakurai, Mamoru Takenaka, Masahiro Takita, Norihisa Yada, Hiroshi Ida, Yasunori Minami, Kazuomi Ueshima, Tomohiro Watanabe, Masatoshi Kudo
BACKGROUND AND AIMS: Direct-acting antivirals (DAAs) dramatically improve the sustained virological response (SVR) of chronic hepatitis C (CHC) patients. However, continuous liver damage after SVR may be a risk of hepatocellular carcinoma (HCC). We clarified pretreatment characteristics related to sustained liver damage after SVR. METHODS: A total of 286 CHC patients were treated with an interferon-free DAA regimen. Among them, 250 patients achieved SVR for 12 weeks after the end of treatment (SVR12); these individuals were classified based on α-fetoprotein (AFP) and alanine transaminase (ALT) levels posttreatment...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040987/hepatocarcinogenesis-is-associated-with-serum-albumin-levels-after-sustained-virological-responses-with-interferon-based-therapy-in-patients-with-hepatitis-c
#6
Yasuko Umehara, Satoru Hagiwara, Naoshi Nishida, Toshiharu Sakurai, Hiroshi Ida, Yasunori Minami, Masahiro Takita, Tomohiro Minami, Hirokazu Chishina, Kazuomi Ueshima, Yoriaki Komeda, Tadaaki Arizumi, Tomohiro Watanabe, Masatoshi Kudo
OBJECTIVE: It is a generally accepted fact that eradication of hepatitis virus C inhibits the subsequent development of hepatocellular carcinoma (HCC). On the contrary, a significant population of patients developed HCC despite sustained virological responses (SVRs) to interferon (IFN) therapy. METHODS: A total of 415 patients with chronic hepatitis C, who were treated at our hospital between 2004 and 2014, were enrolled for this study. We examined the risk factors for HCC development after IFN therapy...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040986/comparison-of-sofosbuvir-plus-ribavirin-treatment-with-pegylated-interferon-plus-ribavirin-treatment-for-chronic-hepatitis-c-genotype-2
#7
Kayo Seo, Soo Ki Kim, Soo Ryang Kim, Aya Ohtani, Mana Kobayashi, Airi Kato, Eri Morimoto, Yuka Saijo, Ke Ih Kim, Susumu Imoto, Chi Wan Kim, Yoshihiko Yano, Masatoshi Kudo, Yoshitake Hayashi
BACKGROUND: Sofosbuvir plus ribavirin (RBV) therapy showed higher sustained virological response at 12 weeks after treatment (SVR12) than pegylated interferon (peg-IFN) plus RBV; however, liver function, fibrosis, and hepatocellular carcinoma markers have not been assessed so far. SUMMARY: Patients (n = 21) receiving Sofosbuvir plus RBV and those (n = 24) receiving peg-IFN plus RBV were enrolled in this study. Changes in alanine aminotransferase (ALT) and α-fetoprotein (AFP) levels, platelet (PLT) counts, FIB-4, and aspartate aminotransferase-to-platelet ratio index (APRI) in both groups were assessed in patients achieving SVR12...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040985/serum-ifn-%C3%AE-3-levels-correlate-with-serum-hepatitis-c-virus-rna-levels-in-symptomatic-patients-with-acute-hepatitis-c
#8
Susumu Imoto, Soo Ryang Kim, Keisuke Amano, Etsuko Iio, Seitetsu Yoon, Shigeya Hirohata, Yoshihiko Yano, Toru Ishikawa, Shinji Katsushima, Toshiki Komeda, Toyokazu Fukunaga, Hobyung Chung, Hiroyuki Kokuryu, Yutaka Horie, Takashi Hatae, Aya Fujinami, Soo Ki Kim, Masatoshi Kudo, Yasuhito Tanaka
BACKGROUND: Recent genome-wide association studies demonstrated that 2 single nucleotide polymorphisms (SNPs), upstream of the interferon-λ (IFNL) 3 gene, are associated with the spontaneous clearance of hepatitis C virus (HCV) in symptomatic patients with acute hepatitis C (AHC). Although these 2 SNPs, rs8099917 and rs12979860, have established their significant roles in the innate immunity response to spontaneously clear HCV in patients with AHC, the detailed mechanisms of their roles remain largely unknown...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040983/diagnosis-of-fibrosis-and-activity-by-a-combined-use-of-strain-and-shear-wave-imaging-in-patients-with-liver-disease
#9
Norihisa Yada, Nobuhura Tamaki, Yohei Koizumi, Masashi Hirooka, Osamu Nakashima, Yoichi Hiasa, Namiki Izumi, Masatoshi Kudo
OBJECTIVE: Performing shear wave imaging is simple, but can be difficult when inflammation, jaundice, and congestion are present. Therefore, the correct diagnosis of liver fibrosis using shear wave imaging alone might be difficult in mild-to-moderate fibrosis cases. Strain imaging can diagnose liver fibrosis without the influence of inflammation. Therefore, the combined use of strain and shear wave imaging (combinational elastography) for cases without jaundice and congestion might be useful for evaluating fibrosis and inflammation...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040982/clinicopathological-study-of-autoimmune-hepatitis-cases-that-were-difficult-to-differentiate-from-drug-induced-liver-injury
#10
Akemi Tsutsui, Kenichi Harada, Koichi Tsuneyama, Tomonori Senoh, Takuya Nagano, Koichi Takaguchi, Midori Ando, Satoko Nakamura, Koichi Mizobuchi, Masatoshi Kudo
AIM: Acute-onset autoimmune hepatitis (AIH) histopathologically presents with features of acute hepatitis and lacks a specific diagnostic method. Also, AIH is often difficult to differentiate from drug-induced liver injury (DILI). We aimed to investigate the final clinical diagnosis of these cases, and compare the clinical, biochemical, and histological characteristics of AIH vs. DILI. METHODS: We examined the Digestive Disease Week Japan 2004 (DDW-J) scale scores, AIH scores, clinical data, and pathological findings in 20 patients in whom it was difficult to differentiate autoimmune liver disease from DILI...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040981/abdominal-ultrasound-findings-of-tumor-forming-hepatic-malignant-lymphoma
#11
Shogo Kitahata, Atsushi Hiraoka, Masatoshi Kudo, Taisei Murakami, Marie Ochi, Hirofumi Izumoto, Hidetaro Ueki, Miho Kaneto, Toshihiko Aibiki, Tomonari Okudaira, Hiroka Yamago, Yuji Miyamoto, Ryuichiro Iwasaki, Hideomi Tomida, Kenichiro Mori, Masato Kishida, Hideki Miyata, Eiji Tsubouchi, Masashi Hirooka, Yohei Koizumi, Tomoyuki Ninomiya, Yoichi Hiasa, Kojiro Michitaka
AIM/BACKGROUND: Evaluations of abdominal ultrasonography (US) findings of primary and secondary tumor-forming hepatic malignant lymphoma (HML) have not been adequately reported. In this study, we elucidated US and contrast-enhanced US (CEUS) findings in patients with HML. MATERIALS/METHODS: From January 2006 to March 2017, 25 patients with HML were enrolled (primary 7, secondary 18), each of whom was diagnosed pathologically. They were divided into 2 groups based on tumor diameter (cutoff, 30 mm)...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29040966/natural-product-celastrol-suppressed-macrophage-m1-polarization-against-inflammation-in-diet-induced-obese-mice-via-regulating-nrf2-ho-1-map-kinase-and-nf-%C3%AE%C2%BAb-pathways
#12
Dan Luo, Yumeng Guo, Yuanyuan Cheng, Jia Zhao, Yu Wang, Jianhui Rong
Macrophage polarization is implicated in the inflammation in obesity. The aim of the present study was to examine the anti-inflammatory activities of botanical triterpene celastrol against diet-induced obesity. We treated diet-induced obese C57BL/6N male mice with celastrol (5, 7.5 mg/kg/d) for 3 weeks, and investigated macrophage M1/M2 polarization in adipose and hepatic tissues. Celastrol reduced fat accumulation and ameliorated glucose tolerance and insulin sensitivity. Celastrol down-regulated the mRNA levels of macrophage M1 biomarkers (e...
October 16, 2017: Aging
https://www.readbyqxmd.com/read/29040945/quercetin-protects-mouse-liver-against-triptolide-induced-hepatic-injury-by-restoring-th17-treg-balance-through-tim-3-and-tlr4-myd88-nf-%C3%AE%C2%BAb-pathway
#13
Cai-Bing Wei, Kun Tao, Rong Jiang, Lian-Di Zhou, Qi-Hui Zhang, Chun-Su Yuan
Triptolide (TP) is a diterpene triepoxide with various biological activities, but its clinical applications have been limited by potential hepatotoxicity, which can be attributed to T helper 17 (Th17)/T regulatory (Treg) cell imbalance. Quercetin (QE), a natural flavonoid, has been reported to have many benefits and medicinal properties, including hepatoprotective activity against TP-induced liver injury. However, the hepatoprotection mechanisms have not been clarified. The present study was designed to explore the protective effect and the mechanism of QE against TP-induced liver injury...
October 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29040839/effects-of-the-dietary-carbohydrate-fat-ratio-on-plasma-phosphatidylcholine-profiles-in-human-and-mouse
#14
Mizuki Inoue, Nanami Senoo, Tomoki Sato, Yuri Nishimura, Takumi Nakagawa, Noriyuki Miyoshi, Toshinao Goda, Akihito Morita, Shinji Miura
Phosphatidylcholines (PCs), a major class of human plasma phospholipids, are composed of highly diverse fatty acids. Because the dietary carbohydrate-fat ratio alters the hepatic fatty acid metabolism, plasma fatty acids that bind PCs, which are secreted as lipoproteins from the liver, may be affected by long-term consumption of a high-carbohydrate diet or a high-fat diet. Therefore, in this study, we profiled the plasma PC species comprehensively in formulated dieting conditions to identify those phospholipid molecules that reflect the dietary carbohydrate-fat ratio...
September 15, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29040738/nf90-nf45-is-a-selective-rna-chaperone-that-rearranges-viral-and-cellular-riboswitches-biochemical-analysis-of-a-virus-host-factor-activity
#15
Tobias Schmidt, Susann Friedrich, Ralph Peter Golbik, Sven-Erik Behrens
The heterodimer NF90-NF45 is an RNA-binding protein complex that modulates the expression of various cellular mRNAs on the post-transcriptional level. Furthermore, it acts as a host factor that supports the replication of several RNA viruses. The molecular mechanisms underlying these activities have yet to be elucidated. Recently, we showed that the RNA-binding capabilities and binding specificity of NF90 considerably improves when it forms a complex with NF45. Here, we demonstrate that NF90 has a substrate-selective RNA chaperone activity (RCA) involving RNA annealing and strand displacement activities...
October 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29040650/interferon-alpha-reduces-human-hippocampal-neurogenesis-and-increases-apoptosis-via-activation-of-distinct-stat1-dependent-mechanisms
#16
Alessandra Borsini, Annamaria Cattaneo, Chiara Malpighi, Sandrine Thuret, Neil A Harrison, Patricia A Zunszain, Carmine M Pariante
Background: In humans, interferon-α treatment for chronic viral hepatitis is a well-recognized clinical model for inflammation-induced depression, but the molecular mechanisms underlying these effects are not clear. Following peripheral administration in rodents, interferon-α induces signal transducer and activator of transcription-1 (STAT1) within the hippocampus and disrupts hippocampal neurogenesis. Methods: We used the human hippocampal progenitor cell line HPC0A07/03C to evaluate the effects of 2 concentrations of interferon-α, similar to those observed in human serum during its therapeutic use (500 pg/mL and 5000 pg/mL), on neurogenesis and apoptosis...
October 10, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29040465/the-fut2-secretor-variant-p-trp154ter-influences-serum-vitamin-b12-concentration-via-holo-haptocorrin-but-not-holo-transcobalamin-and-is-associated-with-haptocorrin-glycosylation
#17
Aneliya Velkova, Jennifer E L Diaz, Faith Pangilinan, Anne M Molloy, James L Mills, Barry Shane, Erica Sanchez, Conal Cunningham, Helen McNulty, Cheryl D Cropp, Joan E Bailey-Wilson, Alexander F Wilson, Lawrence C Brody
Vitamin B12 deficiency is common in older individuals. Circulating vitamin B12 concentration can be used to diagnose deficiency but this test has substantial false positive and false negative rates. We conducted genome-wide association studies (GWAS) in which we resolved total serum vitamin B12 into the fractions bound to transcobalamin and haptocorrin: two carrier proteins with very different biological properties. We replicated reported associations between total circulating vitamin B12 concentrations and a common null variant in FUT2...
October 12, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29040439/eicosapentaenoic-acid-attenuates-obesity-related-hepatocellular-carcinogenesis
#18
Akane Inoue-Yamauchi, Hiroko Itagaki, Hideaki Oda
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of obesity, is an emerging risk factor for hepatocellular carcinoma (HCC). Accumulating evidence has shown that chronic inflammation represents a plausible link between obesity and HCC, and that the pro-inflammatory cytokine IL-6 contributes to the development of obesity-related HCC. In the present study, we aimed to examine the therapeutic potential of the omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA), which exerts anti-inflammatory effects...
October 12, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29040318/rapid-reversal-of-innate-immune-dysregulation-in-blood-of-patients-and-livers-of-humanized-mice-with-hcv-following-daa-therapy
#19
Matthew A Burchill, Justin A Roby, Nanette Crochet, Megan Wind-Rotolo, Amy E Stone, Michael G Edwards, Rachael J Dran, Michael S Kriss, Michael Gale, Hugo R Rosen
RESULTS: First, in patients receiving two different combinations of DAAs, we found that DAAs induced not only rapid viral clearance, but also a re-setting of antiviral immune responses in the peripheral blood. Specifically, we see a rapid decline in the expression of genes associated with chronic IFN stimulation (IFIT3, USP18, IFIT1) as well as a rapid decline in genes associated with inflammation (IL1β, CXCL10, CXCL11) in the peripheral blood that precedes the complete removal of virus from the blood...
2017: PloS One
https://www.readbyqxmd.com/read/29040071/prevalence-and-direct-costs-of-emergency-department-visits-and-hospitalizations-for-selected-diseases-that-can-be-transmitted-by-water-united-states
#20
E A Adam, S A Collier, K E Fullerton, J W Gargano, M J Beach
National emergency department (ED) visit prevalence and costs for selected diseases that can be transmitted by water were estimated using large healthcare databases (acute otitis externa, campylobacteriosis, cryptosporidiosis, Escherichia coli infection, free-living ameba infection, giardiasis, hepatitis A virus (HAV) infection, Legionnaires' disease, nontuberculous mycobacterial (NTM) infection, Pseudomonas-related pneumonia or septicemia, salmonellosis, shigellosis, and vibriosis or cholera). An estimated 477,000 annual ED visits (95% CI: 459,000-494,000) were documented, with 21% (n = 101,000, 95% CI: 97,000-105,000) resulting in immediate hospital admission...
October 2017: Journal of Water and Health
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