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https://www.readbyqxmd.com/read/29326178/impact-of-replacing-cytology-with-human-papillomavirus-testing-for-cervical-cancer-screening-on-the-prevalence-of-trichomonas-vaginalis-a-modelling-study
#1
Ben B Hui, Caitlin P Reulein, Rebecca J Guy, Basil Donovan, Jane S Hocking, Matthew G Law, David G Regan
OBJECTIVES: Trichomonas vaginalis (TV) is the most common curable STI worldwide and is associated with increased risk of HIV acquisition and serious reproductive morbidities. The prevalence of TV infection is very low in Australian cities, and this is thought to be at least partly due to incidental detection and treatment of TV in women participating in the cervical cytology screening programme. In 2017, the national cervical screening programme will transition to a new model based on testing for high-risk (HR) human papillomavirus (HPV), with a reduced frequency and commencement at an older age...
January 11, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29324755/hiv-1-co-receptor-tropism-and-liver-fibrosis-in-hiv-infected-patients
#2
Annalisa Saracino, Alessandro Cozzi-Lepri, Milensu Shanyinde, Francesca Ceccherini Silberstein, Silvia Nozza, Antonio Di Biagio, Giovanni Cassola, Giuseppe Bruno, Maria Capobianchi, Massimo Puoti, Laura Monno, Antonella d'Arminio Monforte
BACKGROUND: In vitro, gp120 of both X4 and R5 HIV-1 strains activates human hepatic stellate cells, but if it can promote liver fibrosis in vivo is unknown. We aimed to evaluate if patients carrying X4 or R5 strains have a different liver fibrosis (LF) progression over time. METHODS: A total of 1,137 HIV-infected patients in ICONA cohort (21% females, 7% HCV co-infected) with an available determination of HIV-1 co-receptor tropism (CRT), a Fibrosis-4 Index for Liver Fibrosis (FIB-4) <3...
2018: PloS One
https://www.readbyqxmd.com/read/29316885/cash-transfer-interventions-for-sexual-health-meanings-and-experiences-of-adolescent-males-and-females-in-inner-city-johannesburg
#3
Nomhle Khoza, Jonathan Stadler, Catherine MacPhail, Admire Chikandiwa, Heena Brahmbhatt, Sinead Delany-Moretlwe
BACKGROUND: In sub-Saharan Africa, there is growing interest in the use of cash transfer (CT) programs for HIV treatment and prevention. However, there is limited evidence of the consequences related to CT provision to adolescents in low-resourced urban settings. We explored the experiences of adolescents receiving CTs to assess the acceptability and unintended consequences of CT strategies in urban Johannesburg, South Africa. METHODS: We collected qualitative data during a pilot randomized controlled trial of three CT strategies (monthly payments unconditional vs...
January 10, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29315954/development-and-validation-of-an-assay-to-analyze-atazanavir-in-human-hair-via-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms
#4
Nhi Phung, Karen Kuncze, Hideaki Okochi, Alexander Louie, Leslie Z Benet, Igho Ofokotun, David W Haas, Judith S Currier, Tariro D Chawana, Anandi N Sheth, Peter Bacchetti, Monica Gandhi, Howard Horng
Assays to quantify antiretrovirals in hair samples are increasingly used to monitor adherence and exposure in both HIV prevention and treatment studies. Atazanavir (ATV) is a protease inhibitor used in combination antiretroviral therapy (ART). We developed and validated a liquid chromatography tandem mass spectrometry (LC-MS/MS)-based method to quantify ATV in human hair, per the NIH Division of AIDS' Clinical Pharmacology Quality Assurance (CPQA) program and the FDA bioanalytical method validation guidelines...
January 9, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29311557/publisher-correction-the-%C3%AE-20-%C3%AE-21-of-gp120-is-a-regulatory-switch-for-hiv-1-env-conformational-transitions
#5
Alon Herschhorn, Christopher Gu, Francesca Moraca, Xiaochu Ma, Mark Farrell, Amos B Smith, Marie Pancera, Peter D Kwong, Arne Schön, Ernesto Freire, Cameron Abrams, Scott C Blanchard, Walther Mothes, Joseph G Sodroski
The original version of this Article contained an error in the spelling of the author Amos B. Smith, III, which was incorrectly given as Amos B. SmithIII. This has now been corrected in both the PDF and HTML versions of the Article.
January 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29305880/distinct-effects-of-hiv-protease-inhibitors-and-erad-inhibitors-on-zygote-to-ookinete-transition-of-the-malaria-parasite
#6
Evi Goulielmaki, Sofia Kaforou, Kannan Venugopal, Thanasis G Loukeris, Inga Siden-Kiamos, Konstantinos Koussis
In an effort to eradicate malaria, new interventions are proposed to include compound/vaccine development against pre-erythrocytic, erythrocytic and mosquito stages of Plasmodium. Drug repurposing might be an alternative approach to new antimalarials reducing the cost and the time required for drug development. Previous in vitro studies have examined the effects of protease inhibitors on different stages of the Plasmodium parasite, although the clinical relevance of this remains unclear. In this study we tested the putative effect of three HIV protease inhibitors, two general aspartyl protease inhibitors and three AAA-p97 ATPase inhibitors on the zygote to ookinete transition of the Plasmodium parasite...
January 3, 2018: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/29289699/does-integrating-aids-treatment-with-food-assistance-affect-labor-supply-evidence-from-zambia
#7
Nyasha Tirivayi, Wim Groot
In low income settings, food assistance is increasingly becoming part of AIDS treatment and care programs with the aim of improving adherence to AIDS treatment, enhancing household food security and strengthening economic wellbeing. Yet, evidence of its economic impact is sparse. This paper uses primary data to examine the short term impact of a food assistance program on labor supply as measured by the hours worked, labor market participation rates and transitions to employment within HIV/AIDS affected households in Zambia...
December 14, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/29284718/cohort-profile-study-of-transition-outcomes-and-gender-strong-to-assess-health-status-of-transgender-people
#8
Virginia P Quinn, Rebecca Nash, Enid Hunkeler, Richard Contreras, Lee Cromwell, Tracy A Becerra-Culqui, Darios Getahun, Shawn Giammattei, Timothy L Lash, Andrea Millman, Brandi Robinson, Douglas Roblin, Michael J Silverberg, Jennifer Slovis, Vin Tangpricha, Dennis Tolsma, Cadence Valentine, Kevin Ward, Savannah Winter, Michael Goodman
PURPOSE: The Study of Transition, Outcomes and Gender (STRONG) was initiated to assess the health status of transgender people in general and following gender-affirming treatments at Kaiser Permanente health plans in Georgia, Northern California and Southern California. The objectives of this communication are to describe methods of cohort ascertainment and data collection and to characterise the study population. PARTICIPANTS: A stepwise methodology involving computerised searches of electronic medical records and free-text validation of eligibility and gender identity was used to identify a cohort of 6456 members with first evidence of transgender status (index date) between 2006 and 2014...
December 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/29276983/uplc-ms-ms-method-for-the-simultaneous-quantification-of-sofosbuvir-sofosbuvir-metabolite-gs-331007-and-daclatasvir-in-plasma-of-hiv-hcv-co-infected-patients
#9
Stefania Notari, Massimo Tempestilli, Gabriele Fabbri, Raffaella Libertone, Andrea Antinori, Adriana Ammassari, Chiara Agrati
Direct-acting antiviral agents (DAAs) represent the major advance in hepatitis C virus (HCV) infection treatment leading to extremely high eradication rates in HCV mono- and HIV/HCV co-infected patients. In this scenery, availability of Therapeutic Drug Monitoring (TDM) is of interest to assess plasma concentrations to prevent either therapeutic failure due to suboptimal medication adherence and drug-drug interactions or avoid adverse events. Aim of this study was to develop and validate an Ultra-Performance Liquid Chromatography Mass Spectrometry (UPLC-MS/MS) method for the simultaneous quantification of sofosbuvir, sofosbuvir metabolite (GS-331007), and daclatasvir in human plasma...
December 12, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29250430/divergent-hiv-1-strains-crf92_c2u-and-crf93_cpx-co-circulating-in-the-democratic-republic-of-the-congo-phylogenetic-insights-on-the-early-evolutionary-history-of-subtype-c
#10
C J Villabona Arenas, N Vidal, S Ahuka Mundeke, J Muwonga, L Serrano, J J Muyembe, F Boillot, E Delaporte, M Peeters
Molecular epidemiological studies revealed that the epicenter of the HIV pandemic was Kinshasa, the capital city of the Democratic Republic of the Congo (DRC) in Central Africa. All known subtypes and numerous complex recombinant strains co-circulate in the DRC. Moreover, high intra-subtype diversity has been also documented. During two previous surveys on HIV-1 antiretroviral drug resistance in the DRC, we identified two divergent subtype C lineages in the protease and partial reverse transcriptase gene regions...
July 2017: Virus Evolution
https://www.readbyqxmd.com/read/29248971/connecting-corrections-and-hiv-care-building-a-care-coordination-program-for-recently-incarcerated-persons-living-with-hiv-in-virginia
#11
Steven Bailey, Kathryn Gilmore, Lauren Yerkes, Anne Rhodes
Incarcerated individuals are disproportionately affected by HIV and often experience risk factors associated with poor maintenance of HIV care upon release. Therefore, the transition period from incarceration to the community is a particularly critical time for persons living with HIV to ensure continuity of care and treatment. By building relationships with Department of Corrections staff and community partners, the Virginia Department of Health developed a program to link recently incarcerated persons living with HIV to care and treatment immediately upon release from correctional facilities across Virginia...
December 16, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29237487/adolescent-coordinated-transition-act-to-improve-health-outcomes-among-young-people-living-with-hiv-in-nigeria-study-protocol-for-a-randomized-controlled-trial
#12
Nadia A Sam-Agudu, Jennifer R Pharr, Tamara Bruno, Chad L Cross, Llewellyn J Cornelius, Prosper Okonkwo, Bolanle Oyeledun, Hadiza Khamofu, Ayodotun Olutola, Salome Erekaha, William Nii Ayitey Menson, Echezona E Ezeanolue
BACKGROUND: Adolescents living with HIV (ALHIV) have worse health outcomes than other populations of people living with HIV. Contributing factors include lack of standard and comprehensive procedures for ALHIV transitioning from pediatric to adult care. This has contributed to poor retention at, and following transition, which is problematic especially in high ALHIV-burden, resource-limited settings like Nigeria. METHODS: Using a two-arm cluster randomized control design, the Adolescent Coordinated Transition (ACT) trial will measure the comparative effectiveness of a graduated transition and organized support group intervention against the usual practice of abrupt transfer of Nigerian ALHIV from pediatric to adult care...
December 14, 2017: Trials
https://www.readbyqxmd.com/read/29235927/risk-factors-for-hospital-death-in-conditions-needing-palliative-care-nationwide-population-based-death-certificate-study
#13
Barbara Gomes, Maria João Pinheiro, Sílvia Lopes, Maja de Brito, Vera P Sarmento, Pedro Lopes Ferreira, Henrique Barros
BACKGROUND: Most people would prefer to die at home as opposed to hospital; therefore, understanding mortality patterns by place of death is essential for health resources allocation. AIM: We examined trends and risk factors for hospital death in conditions needing palliative care in a country without integrated palliative care. DESIGN: This is a death certificate study. We examined factors associated with hospital death using logistic regression...
November 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29227443/associations-between-medicare-part-d-and-out-of-pocket-spending-hiv-viral-load-adherence-and-adap-use-in-dual-eligibles-with-hiv
#14
Nadya Belenky, Brian W Pence, Stephen R Cole, Stacie B Dusetzina, Andrew Edmonds, Jonathan Oberlander, Michael W Plankey, Adebola Adedimeji, Tracey E Wilson, Jennifer Cohen, Mardge H Cohen, Joel E Milam, Elizabeth T Golub, Adaora A Adimora
BACKGROUND: The implementation of Medicare part D on January 1, 2006 required all adults who were dually enrolled in Medicaid and Medicare (dual eligibles) to transition prescription drug coverage from Medicaid to Medicare part D. Changes in payment systems and utilization management along with the loss of Medicaid protections had the potential to disrupt medication access, with uncertain consequences for dual eligibles with human immunodeficiency virus (HIV) who rely on consistent prescription coverage to suppress their HIV viral load (VL)...
January 2018: Medical Care
https://www.readbyqxmd.com/read/29219248/-my-mother-told-me-that-i-should-not-a-qualitative-study-exploring-the-restrictions-placed-on-adolescent-girls-living-with-hiv-in-zambia
#15
Constance Rs Mackworth-Young, Virginia Bond, Alison Wringe, Katongo Konayuma, Sue Clay, Chipo Chiiya, Mutale Chonta, Kirsty Sievwright, Anne L Stangl
INTRODUCTION: Adolescent girls in sub-Saharan Africa are disproportionately affected by HIV due to a range of social and structural factors. As they transition to adulthood, they are recipients of increasing blame for HIV infection and 'improper' sex, as well as increasing scrutiny, restrictions and surveillance. This study used a qualitative and participatory approach to explore the messaging and restrictions imposed on adolescent girls living with HIV in Zambia. METHODS: Thirty-four in-depth interviews and four participatory workshops were carried out with 24 adolescent girls aged 15 to 19 years old living with HIV in Lusaka, Zambia...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29210712/optimizing-hiv-transition-services-for-young-adults
#16
Caroline Foster, Sarah Fidler
PURPOSE OF REVIEW: A total of 1.8 million adolescents live with HIV and constitute the only age group in which HIV-associated mortality continues to rise. Meeting their healthcare needs as they transition from paediatric services to adult care is vital for their own health and in prevention of onward transmission to partners and offspring. In this review, we discuss the issues around transition, both within HIV health care and the wider transitions adolescents negotiate as they move out of childhood and into adult life...
November 27, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29208587/hiv-surveillance-among-pregnant-women-attending-antenatal-clinics-evolution-and-current-direction
#17
Jacob Dee, Jesus M Garcia Calleja, Kimberly Marsh, Irum Zaidi, Christopher Murrill, Mahesh Swaminathan
Since the late 1980s, human immunodeficiency virus (HIV) sentinel serosurveillance among pregnant women attending select antenatal clinics (ANCs) based on unlinked anonymous testing (UAT) has provided invaluable information for tracking HIV prevalence and trends and informing global and national HIV models in most countries with generalized HIV epidemics. However, increased coverage of HIV testing, prevention of mother-to-child transmission (PMTCT), and antiretroviral therapy has heightened ethical concerns about UAT...
December 5, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29206999/expansion-of-viral-load-testing-and-the-potential-impact-on-hiv-drug-resistance
#18
Elliot Raizes, Shannon Hader, Deborah Birx
The US President's Emergency Plan for AIDS Relief (PEPFAR) supports aggressive scale-up of antiretroviral therapy (ART) in high-burden countries and across all genders and populations at risk toward global human immunodeficiency virus (HIV) epidemic control. PEPFAR recognizes the risk of HIV drug resistance (HIVDR) as a consequence of aggressive ART scale-up and is actively promoting 3 key steps to mitigate the impact of HIVDR: (1) routine access to routine viral load monitoring in all settings; (2) optimization of ART regimens; and (3) routine collection and analysis of HIVDR data to monitor the success of mitigation strategies...
December 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29199188/cost-effective-osteoporosis-treatment-thresholds-for-people-living-with-hiv-infection-in-greece
#19
P Makras, N Boubouchairopoulou, I Katsarolis, K Athanasakis
OBJECTIVES: We aimed to specifically define the FRAX-based cost-effective treatment thresholds for osteoporosis among people living with HIV (PLWHIV) in Greece and to compare them with those of the general population. METHODS: A previously described state transition Markov cohort model was used in order to estimate the cost-effective intervention thresholds for osteoporotic therapy among Greek PLWHIV employing the FRAX® tool. The model-derived relative risk at which an incremental cost-effectiveness ratio of 30,000€/QALY gained was observed for treatment versus no intervention was multiplied by the average Greek FRAX-based 10-year probabilities for both major osteoporotic and hip fractures...
December 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/29194121/hiv-infected-cannabis-users-have-lower-circulating-cd16-monocytes-and-ip-10-levels-compared-to-non-using-hiv-patients
#20
Michael D Rizzo, Robert B Crawford, Joseph E Henriquez, Yasser Aldhamen, Peter Gulick, Andrea Amalfitano, Norbert E Kaminski
OBJECTIVE: Chronic immune activation and elevated numbers of circulating activated monocytes (CD16) are implicated in HIV-associated neuroinflammation. The objective was to compare the level of circulating CD16 monocytes and interferon-γ-inducible protein 10 (IP-10) between HIV-infected cannabis users (HIV+MJ+) and non-cannabis users (HIV+MJ-), and determine whether in vitro Δ-Tetrahydrocannabinol (THC), a constituent of cannabis, affected CD16 expression as well as IP-10 production by monocytes...
November 30, 2017: AIDS
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