keyword
MENU ▼
Read by QxMD icon Read
search

Transition in hiv

keyword
https://www.readbyqxmd.com/read/28652115/longitudinal-trends-of-hiv-drug-resistance-in-a-large-canadian-cohort-1996-2016
#1
Genevieve Rocheleau, Chanson J Brumme, Jeannie Shoveller, Viviane Lima, Richard Harrigan
OBJECTIVES: We aim to identify long-term trends in HIV drug resistance before and after combined antiretroviral therapy (cART) initiation. METHODS: IAS-USA (2015) mutations were identified in 23,271 HIV protease-reverse transcriptase sequences from 6543 treatment naïve British Columbia adults. Participants that started cART between 1996-2014 were followed until April 2016. Equality of proportions test compared the percentage of participants with acquired drug resistance (ADR) or transmitted drug resistance (TDR) in 1996, to those in 2014...
June 23, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28650703/program-implementation-of-option-b%C3%A2-at-a-president-s-emergency-plan-for-aids-relief-supported-hiv-clinic-improves-clinical-indicators-but-not-retention-in-care-in-mbarara-uganda
#2
Kathleen Miller, Winnie Muyindike, Lynn T Matthews, Michael Kanyesigye, Mark J Siedner
2013 WHO guidelines for prevention of mother to child transmission recommend combination antiretroviral therapy (ART) for all pregnant women, regardless of CD4 count (Option B/B+). We conducted a retrospective analysis of data from a government-operated HIV clinic in Mbarara, Uganda before and after implementation of Option B+ to assess the impact on retention in care. We limited our analysis to women not on ART at the time of their first reported pregnancy with CD4 count >350. We fit regression models to estimate relationships between calendar period (Option A vs...
June 26, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28643392/retroviruses-and-microtubule-associated-motor-proteins
#3
REVIEW
Gloria Arriagada
Retroviruses are obligate intracellular parasites of eukaryotic cells. After reverse transcription, the viral DNA contained in the preintegration complex (PIC) is delivered to the nucleus of the host cell, where it integrates. Before reaching the nucleus, the incoming particle and the PIC must travel throughout the cytoplasm. Likewise the newly synthesized viral proteins and viral particles must transit the cytoplasm during exit. The cytoplasm is a crowded environment and simple diffusion is difficult. Therefore, viruses have evolved to utilize the cellular mechanisms of movement through the cytoplasm, where microtubules are the roads, and the ATP dependent motors dynein and kinesin are the vehicles for retrograde and anterograde trafficking...
June 22, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28639838/provider-perceptions-of-stigma-and-discrimination-experienced-by-adolescents-and-young-adults-with-phiv-while-accessing-sexual-and-reproductive-health-care
#4
Cynthia D Fair, Meredith Berk
Historically, children with perinatally-acquired HIV (PHIV) were viewed as the "innocent victims" as their HIV infection was not acquired through sexual/drug related means. Today, adolescents with PHIV are surviving into young adulthood and are engaging in developmentally expected behaviors such as establishing intimate, sexual relationships. Like other youth, those living with PHIV often need to access sexual and reproductive health (SRH) services. Previous research has documented stigma and discrimination experienced by adult women living with HIV as they try to access SRH care...
June 22, 2017: AIDS Care
https://www.readbyqxmd.com/read/28629799/self-efficacy-and-coping-as-correlates-of-migrant-safe-sexual-behavior-to-prevent-hiv
#5
Jesús Alejandro Guerra-Ordoñez, Raquel A Benavides-Torres, Dora Julia Onofre-Rodríguez, María Aracely Márquez-Vega, Gloria Maricela Guerra-Rodríguez, Kristin M Wall
Along the Mexico/United States border, migrants are at increased risk of HIV. The objective of our study was to investigate the relationship between two process indicators (self-efficacy to prevent HIV and coping with sexual risk) and safe sexual behaviors in migrants. A correlational design was used. Migrants were recruited from two cities on the northern border of Mexico. Transition theory informed the measurement of self-efficacy and coping process indicators. Three generalized linear models were built for each safe sexual behavior outcome: (a) partner communication, (b) use of condoms, and (c) safe sex...
June 7, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28623359/allosteric-modulatory-effects-of-sri-20041-and-sri-30827-on-cocaine-and-hiv-1-tat-protein-binding-to-human-dopamine-transporter
#6
Wei-Lun Sun, Pamela M Quizon, Yaxia Yuan, Wei Zhang, Subramaniam Ananthan, Chang-Guo Zhan, Jun Zhu
Dopamine transporter (DAT) is the target of cocaine and HIV-1 transactivator of transcription (Tat) protein. Identifying allosteric modulatory molecules with potential attenuation of cocaine and Tat binding to DAT are of great scientific and clinical interest. We demonstrated that tyrosine 470 and 88 act as functional recognition residues in human DAT (hDAT) for Tat-induced inhibition of DA transport and transporter conformational transitions. Here we investigated the allosteric modulatory effects of two allosteric ligands, SRI-20041 and SRI-30827 on cocaine binding on wild type (WT) hDAT, Y470 H and Y88 F mutants...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28609788/resolving-sugar-puckers-in-rna-excited-states-exposes-slow-modes-of-repuckering-dynamics
#7
Mary C Clay, Laura R Ganser, Dawn K Merriman, Hashim M Al-Hashimi
Recent studies have shown that RNAs exist in dynamic equilibrium with short-lived low-abundance 'excited states' that form by reshuffling base pairs in and around non-canonical motifs. These conformational states are proposed to be rich in non-canonical motifs and to play roles in the folding and regulatory functions of non-coding RNAs but their structure proves difficult to characterize given their transient nature. Here, we describe an approach for determining sugar pucker conformation in RNA excited states through nuclear magnetic resonance measurements of C1΄ and C4΄ rotating frame spin relaxation (R1ρ) in uniformly 13C/15N labeled RNA samples...
June 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28599596/transitioning-hiv-infected-adolescents-to-adult-care-at-14-clinics-across-the-united-states-using-adolescent-and-adult-providers-insights-to-create-multi-level-solutions-to-address-transition-barriers
#8
Morgan M Philbin, Amanda E Tanner, Brittany D Chambers, Alice Ma, Samuella Ware, Sonia Lee, J Dennis Fortenberry, The Adolescent Trials Network
HIV-infected adolescents have disproportionately low rates of care retention and viral suppression. Approximately half disengage from care while transitioning to adult clinics, in part due to fragmented care systems and lack of streamlined protocols. We conducted 58 qualitative interviews with social service and health care providers across 14 Adolescent Trials Network clinics (n = 28) and 20 adult clinics that receive transitioning adolescents (n = 30) from August 2015-June 2016. We used the constant comparative approach to examine processes, barriers, and facilitators of adult care transition...
June 9, 2017: AIDS Care
https://www.readbyqxmd.com/read/28598724/prevalence-awareness-and-factors-associated-with-hypertension-in-north-west-tanzania
#9
Neema R Mosha, Michael Mahande, Adinan Juma, Innocent Mboya, Rob Peck, Mark Urassa, Denna Michael, Jim Todd
BACKGROUND: Hypertension is a public health problem, and yet few people are aware of it and even fewer access effective treatment. With the ongoing demographic transition in many parts of Sub-Saharan Africa, people are changing from rural, manual work to urban lifestyles, hence the risk of hypertension increases. OBJECTIVE: This study aimed at determining the prevalence, awareness and risk factors associated with hypertension in North West Tanzania. DESIGN: A community-based cross-sectional study was conducted among adults in Magu District in 2013...
2017: Global Health Action
https://www.readbyqxmd.com/read/28597752/withdrawal-of-long-term-epoprostenol-therapy-in-pulmonary-arterial-hypertension-pah
#10
George Calcaianu, Mihaela Calcaianu, Matthieu Canuet, Irina Enache, Romain Kessler
Once initiated for pulmonary arterial hypertension (PAH), epoprostenol treatment usually needs to be delivered for an indefinite duration. It is possible that some participants could be transitioned from epoprostenol to oral therapies. We retrospectively evaluated eight PAH participants transitioned from epoprostenol to PAH oral drugs. The criteria for epoprostenol withdrawal were: (1) persistent improvement of clinic and hemodynamic status; (2) stable dose of epoprostenol for the last three months; and (3) the participant's preference for oral therapy after evaluation of risk-benefit...
April 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28589252/manifestations-of-hiv-stigma-and-their-impact-on-retention-in-care-for-people-transitioning-from-prisons-to-communities
#11
Rebecca Kemnitz, Theresa C Kuehl, Karli R Hochstatter, Emily Barker, Anna Corey, Elizabeth A Jacobs, Michael D Repplinger, William J Ehlenbach, David W Seal, James M Sosman, Ryan P Westergaard
BACKGROUND: While most people living with HIV who are incarcerated in United States receive appropriate HIV care while they are in prison, interruptions in antiretroviral therapy and virologic failure are extremely common after they are released. The purpose of this study was to describe whether and how HIV stigma influences continuity of care for people living with HIV while they transition from prison to community settings. METHODS: We conducted semi-structured, telephone-based interviews with 32 adults who received HIV care while residing in a Wisconsin state prison, followed by a second interview 6 months after they returned to their home community...
December 2017: Health & Justice
https://www.readbyqxmd.com/read/28583136/social-structural-factors-influencing-periods-of-injection-cessation-among-marginalized-youth-who-inject-drugs-in-vancouver-canada-an-ethno-epidemiological-study
#12
Jade Boyd, Danya Fast, Megan Hobbins, Ryan McNeil, Will Small
BACKGROUND: Injection drug use is associated with HIV and hepatitis C transmission, overdose, and other preventable harms. These harms are heightened for structurally vulnerable injection drug-using populations, as their social conditions pose barriers to safer injecting. Previous research on injection cessation has largely focused on adult drug-using populations. Little qualitative work has examined the social, structural, and environmental factors that shape periods of injection cessation among youth and young adults...
June 5, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28581820/barriers-and-facilitators-to-hiv-testing-among-zambian-female-sex-workers-in-three-transit-hubs
#13
Michael M Chanda, Amaya G Perez-Brumer, Katrina F Ortblad, Magdalene Mwale, Steven Chongo, Nyambe Kamungoma, Catherine Kanchele, Andrew Fullem, Leah Barresi, Till Bärnighausen, Catherine E Oldenburg
Zambia has a generalized HIV epidemic, and HIV is concentrated along transit routes. Female sex workers (FSWs) are disproportionately affected by the epidemic. HIV testing is the crucial first step for engagement in HIV care and HIV prevention activities. However, to date little work has been done with FSWs in Zambia, and little is known about barriers and facilitators to HIV testing in this population. FSW peer educators were recruited through existing sex worker organizations for participation in a trial related to HIV testing among FSWs...
June 5, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28578686/challenges-and-opportunities-of-optimal-breastfeeding-in-the-context-of-hiv-option-b-guidelines
#14
Pamela Marinda, Nkandu Chibwe, Ernest Tambo, Sidney Lulanga, Christopher Khayeka-Wandabwa
BACKGROUND: In 2013, the World Health Organization released a new set of guidelines widely known as Option B+. Prior to that there were guidelines released in 2010. Option B+ recommends lifelong antiretroviral treatment for all pregnant and breastfeeding women living with Human Immunodeficiency Virus. The study aimed at investigating challenges and opportunities in implementing Infant and Young Child Feeding in the context of Prevention of Mother To Child Transmission (PMTCT) guidelines among HIV positive mothers of children aged 0-24 months...
June 2, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28578217/still-at-risk-an-examination-of-how-street-involved-young-people-understand-experience-and-engage-with-harm-reduction-in-vancouver-s-inner-city
#15
Nikki Bozinoff, Will Small, Cathy Long, Kora DeBeck, Danya Fast
BACKGROUND: Vancouver is an international leader in implementing interventions to reduce harms related to drug use. However, street-involved young people who use drugs continue to be vulnerable to overdose death, hepatitis C (HCV) infection, and high rates of syringe sharing. To better understand this in the context of the intensive public health response, we examined how young people, who are involved in the 'street drug scene', understood, experienced and engaged with harm reduction...
June 1, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28562507/dealing-with-large-scale-supply-lines-when-introducing-new-regimens
#16
Christine Malati, Joshua Rosenfeld, Sherif Mowafy, Trevor Rittmiller, Joel Kuritsky, John Crowley
PURPOSE OF REVIEW: As programs plan the introduction of a new antiretroviral as part of a regimen for HIV treatment, supply chain considerations need to be taken into account. The key to success is balancing the introduction of a new regimen with the phasing out of an old regimen in a manner that does not result in either a shortage or an excess supply of either product while ensuring that patients continue receiving their medications. This necessitates that country programs, donors, and procurement entities possess an appreciation of the global antiretroviral market and understand the dynamics that the manufacturing of new antiretrovirals will have on the transition...
July 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28560896/bayesian-two-part-bent-cable-tobit-models-with-skew-distributions-application-to-aids-studies
#17
Getachew A Dagne
This paper presents a new development of a bent-cable two-part Tobit model to identify both phasic patterns and mixture of advancing (to AIDS) and non-advancing patients of HIV. In identification of such phasic patterns, estimation of a transition period for the development of drug resistance to antiretroviral (ARV) drug or therapy is carried out using longitudinal data that have a gradual change from a declining phase to an increasing phase. In addition to phasic changes, there are also problems of skewness and left-censoring in the response variable because of a lower limit of detection...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28558838/towards-understanding-the-drivers-of-policy-change-a-case-study-of-infection-control-policies-for-multi-drug-resistant-tuberculosis-in-south-africa
#18
Trust Saidi, Faatiema Salie, Tania S Douglas
BACKGROUND: Explaining policy change is one of the central tasks of contemporary policy analysis. In this article, we examine the changes in infection control policies for multi-drug resistant tuberculosis (MDR-TB) in South Africa from the time the country made the transition to democracy in 1994, until 2015. We focus on MDR-TB infection control and refer to decentralised management as a form of infection control. Using Kingdon's theoretical framework of policy streams, we explore the temporal ordering of policy framework changes...
May 30, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28544070/the-importance-of-assessing-out-of-pocket-payments-when-the-financing-of-antiretroviral-therapy-is-transitioned-to-domestic-funding-findings-from-vietnam
#19
Benjamin Johns, Le Bao Chau, Kieu Huu Hanh, Nguyen Thuy Huong, Hoa Mai Do, Anh Thuy Duong, Long Hoang Nguyen
OBJECTIVE: To assess out-of-pocket payments and catastrophic health expenditures among antiretroviral therapy (ART) patients in Vietnam, and to model catastrophic payments under different copayment scenarios when the primary financing of ART changes to social health insurance. METHODS: Cross-sectional facility-based survey of 843 patients at 42 health facilities representative of 87% of ART patients in 2015. RESULTS: Because of donor and government funding, no payments were made for antiretroviral drugs...
May 19, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28542584/the-emergence-and-evolution-of-the-research-fronts-in-hiv-aids-research
#20
David Fajardo-Ortiz, Malaquias Lopez-Cervantes, Luis Duran, Michel Dumontier, Miguel Lara, Hector Ochoa, Victor M Castano
In this paper, we have identified and analyzed the emergence, structure and dynamics of the paradigmatic research fronts that established the fundamentals of the biomedical knowledge on HIV/AIDS. A search of papers with the identifiers "HIV/AIDS", "Human Immunodeficiency Virus", "HIV-1" and "Acquired Immunodeficiency Syndrome" in the Web of Science (Thomson Reuters), was carried out. A citation network of those papers was constructed. Then, a sub-network of the papers with the highest number of inter-citations (with a minimal in-degree of 28) was selected to perform a combination of network clustering and text mining to identify the paradigmatic research fronts and analyze their dynamics...
2017: PloS One
keyword
keyword
107619
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"