Hannes Spittel, Florian Kubek, Katharina Kreskowski, Monika Ziegler, Elisabeth Klein, Ahmed B Hamid, Nadezda Kosyakova, Gopakumar Radhakrishnan, Annelore Junge, Peter Kozlowski, Berndt Schulze, Thomas Martin, Dagmar Huhle, Karl Mehnert, Laura Rodríguez, Mehmet A Ergun, Catherine Sarri, Mariela Militaru, Fedora Stipoljev, Hanne Tittelbach, Faezeh Vasheghani, Marcelo de Bello Cioffi, Shaymaa S Hussein, Xiaobo Fan, Marianne Volleth, Thomas Liehr
Small supernumerary marker chromosomes (sSMC) are known for being present in mosaic form as 47,+mar/46 in >50% of the cases with this kind of extra chromosomes. However, no detailed studies have been done for the mitotic stability of sSMC so far, mainly due to the lack of a corresponding in vitro model system. Recently, we established an sSMC-cell bank (Else Kröner-Fresenius-sSMC-cellbank) with >150 cell lines. Therefore, 93 selected sSMC cases were studied here for the presence of the corresponding marker chromosomes before and after Epstein-Barr virus-induced immortalization...
2014: Cytogenetic and Genome Research