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retinoid investigation

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https://www.readbyqxmd.com/read/28920007/towards-treatment-of-stargardt-disease-workshop-organized-and-sponsored-by-the-foundation-fighting-blindness
#1
REVIEW
Avery E Sears, Paul S Bernstein, Artur V Cideciyan, Carel Hoyng, Peter Charbel Issa, Krzysztof Palczewski, Philip J Rosenfeld, SriniVas Sadda, Ulrich Schraermeyer, Janet R Sparrow, Ilyas Washington, Hendrik P N Scholl
Accumulation of fluorescent metabolic byproducts of the visual (retinoid) cycle is associated with photoreceptor and retinal pigment epithelial cell death in both Stargardt disease and atrophic (nonneovascular) age-related macular degeneration (AMD). As a consequence of this observation, small molecular inhibitors of enzymes in the visual cycle were recently tested in clinical trials as a strategy to protect the retina and retinal pigment epithelium in patients with atrophic AMD. To address the clinical translational needs for therapies aimed at both diseases, a workshop organized by the Foundation Fighting Blindness was hosted by the Department of Pharmacology at Case Western Reserve University on February 17, 2017, at the Tinkham Veale University Center, Cleveland, OH, USA...
September 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28913735/efficacy-and-safety-of-tazarotene-0-1-plus-clindamycin-1-gel-versus-adapalene-0-1-plus-clindamycin-1-gel-in-facial-acne-vulgaris-a-randomized-controlled-clinical-trial
#2
Rituparna Maiti, Chandra Sekhar Sirka, M A Ashique Rahman, Anand Srinivasan, Sansita Parida, Debasish Hota
BACKGROUND: Acne vulgaris is a multifactorial disorder which is ideally treated with combination therapy with topical retinoids and antibiotics. OBJECTIVES: The present study was conducted to compare the efficacy and safety of tazarotene plus clindamycin against adapalene plus clindamycin in facial acne vulgaris. METHODS: This study is a randomized, open-label, parallel design clinical trial conducted on 60 patients with facial acne at the outpatient dermatology department in a tertiary healthcare center...
September 14, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28895668/concepts-and-controversies-in-the-treatment-of-cutaneous-lichen-planus-a-review
#3
Charles Puza, Adela R Cardones
Cutaneous lichen planus (CLP) is a chronic autoimmune disease classically associated with severely pruritic, polygonal, violaceous, flat-topped papules and plaques. Subtypes such as hypertrophic and bullous lichen planus and lichen planus pigmentosus have been described. Treatment can be challenging, and prospective controlled studies are lacking. Corticosteroids remain the major options for topical and systemic treatment, although some non-steroidal options exist. Phototherapy, especially with narrow band ultraviolet B (NB-UVB), is effective, but caution must be taken because of the risk of keobnerization...
September 12, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28886987/consequences-of-the-natural-retinoid-retinoid-x-receptor-ligands-action-in-human-breast-cancer-mda-mb-231-cell-line-focus-on-functional-proteomics
#4
D Flodrova, L Toporova, M Lastovickova, D Macejova, L Hunakova, J Brtko, J Bobalova
The main intention of this study was the investigation of impact of natural biologically active ligands of nuclear retinoid/retinoid X receptors (all-trans and 9-cis retinoic acid) on proteomic pattern in human estrogen receptor negative breast cancer cell line MDA-MB-231. For this purpose, proteomic strategies based on bottom-up method were applied. The total cell proteins were extracted utilizing a commercially Radio-Immunoprecipitation Assay (RIPA) buffer and separated on 2D sodium dodecyl sulfate polyacrylamide gel electrophoresis (2D SDS-PAGE)...
September 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28843100/differential-tissue-regulation-of-peroxisome-proliferator-activated-receptor-%C3%AE-ppar%C3%AE-and-cannabinoid-receptor-1-cb1-gene-transcription-pathways-by-diethylene-glycol-dibenzoate-degb-preliminary-observations-in-a-seabream-sparus-aurata-in-vivo-model
#5
Paolo Cocci, Matteo Mozzicafreddo, Mauro Angeletti, Gilberto Mosconi, Francesco Alessandro Palermo
Today a variety of endocrine disrupting chemicals (EDCs) are recognized in the group of metabolic disruptors, a wide range of environmental contaminants that alter energy balance regulation by affecting the peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor (RXR) pathway. Herein, we investigated the effect of diethylene glycol dibenzoate (DEGB), a dibenzoate-based plasticizer used as alternative to phthalates, on the expression of key genes involved in lipid metabolism and energy balance by using Sparus aurata juveniles as models...
August 19, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28836064/treatment-of-severe-psoriasis-in-children-recommendations-of-an-italian-expert-group
#6
Anna Belloni Fortina, Federico Bardazzi, Samantha Berti, Claudia Carnevale, Vito Di Lernia, Maya El Hachem, Iria Neri, Carlo Mario Gelmetti, Viviana Lora, Carlo Mazzatenta, Mirella Milioto, Gaia Moretta, Annalisa Patrizi, Ketty Peris, Alberto Villani
This article provides comprehensive recommendations for the systemic treatment of severe pediatric psoriasis based on evidence obtained from a systematic review of the literature and the consensus opinion of expert dermatologists and pediatricians. For each systemic treatment, the grade of recommendation (A, B, C) based on the treatment's approval by the European Medicines Agency for childhood psoriasis and the experts' opinions is discussed. The grade of recommendation for narrow-band-ultraviolet B phototherapy, cyclosporine, and retinoids is C, while that for methotrexate is C/B...
August 23, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28826691/cell-size-dependent-upregulation-of-hgf-expression-in-dermal-fibroblasts-impact-on-human-skin-connective-tissue-aging
#7
Zhaoping Qin, Christal A Worthen, Taihao Quan
BACKGROUND: Aged human skin is primarily attributable to loss of collagen, the main structural component of skin. Hepatocyte growth factor (HGF) acts as an anti-fibrotic factor by suppression of collagen production. It is not known whether HGF is involved in age-related collagen deficit in human skin. OBJECTIVE: The objective of this study was to investigate the expression of HGF in human skin, and the underlying mechanisms of age-related elevation of HGF expression...
August 4, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28805934/fragility-of-epidermis-acne-and-post-procedure-lesional-skin
#8
G Fabbrocini, A B Rossi, M-D Thouvenin, C Peraud, V Mengeaud, A Bacquey, M Saint Aroman
'Fragile skin', or skin with lower resistance to aggressors, can be broadly classified into four causal categories: constitutional (age-dependent or associated with specific vulnerable locations on the body, e.g. eyelids), pathological (related to disease), circumstantial (related to environmental or internal factors, e.g. stress) and iatrogenic (caused by medical interventions or treatments). In this supplement, we focus on the fourth category, the iatrogenic origin of fragile skin and the role that dermo-cosmetics can have in restoring the natural protective function of the skin following treatments for skin diseases and medical interventions...
September 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28805741/alcohol-and-cancer-mechanisms-and-therapies
#9
REVIEW
Anuradha Ratna, Pranoti Mandrekar
Several scientific and clinical studies have shown an association between chronic alcohol consumption and the occurrence of cancer in humans. The mechanism for alcohol-induced carcinogenesis has not been fully understood, although plausible events include genotoxic effects of acetaldehyde, cytochrome P450 2E1 (CYP2E1)-mediated generation of reactive oxygen species, aberrant metabolism of folate and retinoids, increased estrogen, and genetic polymorphisms. Here, we summarize the impact of alcohol drinking on the risk of cancer development and potential underlying molecular mechanisms...
August 14, 2017: Biomolecules
https://www.readbyqxmd.com/read/28790988/non-antibiotic-isotretinoin-treatment-differentially-controls-propionibacterium-acnes-on-skin-of-acne-patients
#10
Angela E Ryan-Kewley, David R Williams, Neill Hepburn, Ronald A Dixon
Emergence and potential transfer of antibiotic resistance in skin microorganisms is of current concern in medicine especially in dermatology contexts where long term treatment with antibiotics is common. Remarkably, non-antibiotic therapy in the form of isotretinoin - a non-antimicrobial retinoid is effective at reducing or eradicating the anaerobe Propionibacterium acnes which is causally involved in the complex pathogenesis of Acne vulgaris. This study measured the extent of colonization of P. acnes in patients with primary cystic or severe acne from three defined skin sites in 'non-lesion' areas before, during and after treatment with isotretinoin...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28780307/neuroprotective-effect-of-tetramethylpyrazine-against-all-trans-retinal-toxicity-in-the-differentiated-y-79-cells-via-upregulation-of-irbp-expression
#11
Ke Wang, Xue Zhu, Kai Zhang, Fanfan Zhou, Ling Zhu
It is estimated that abnormal accumulation of all-trans-retinal (atRAL) is a leading cause of photoreceptor degeneration in retinal degenerative diseases. Deficiency of interphotoreceptor retinoid-binding protein (IRBP), a retinoid transporter in the visual cycle, is responsible for the impaired clearance of atRAL and results in atRAL toxicity in retina. Therefore, IRBP has been proposed to be a potent target in preventing atRAL-induced photoreceptor degeneration. In this study, the neuroprotective effect of tetramethylpyrazine (TMP) against atRAL toxicity in the differentiated Y-79 cells, a in vitro model of photoreceptor, was first investigated...
August 3, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28774779/extensive-and-functional-overlap-of-the-stat6-and-rxr-cistromes-in-the-active-enhancer-repertoire-of-human-cd14-monocyte-derived-differentiating-macrophages
#12
Zsolt Czimmerer, Zsuzsanna S Nagy, Gergely Nagy, Attila Horvath, Timea Silye-Cseh, Agnes Kriston, David Jonas, Sascha Sauer, Laszlo Steiner, Bence Daniel, Jean-Francois Deleuze, Laszlo Nagy
Macrophages are able to differentiate into classically polarized (M1) or alternatively polarized (M2) states upon encountering pro-inflammatory cytokines such as interferon (IFN) γ or anti-inflammatory cytokines such as interleukin (IL) -4/IL-13, respectively. Moreover, macrophages are known to regulate lipid metabolism via multiple members of the nuclear hormone receptor family, including the retinoid X receptors (RXR). It has been also documented that cytokines are able to modulate macrophage responses to lipid signals but the nature of these interactions and the underlying mechanisms of these processes especially at the level of the chromatinized genome are not well understood...
July 31, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28766169/retinoid-acid-and-taurine-promote-neurod1-induced-differentiation-of-induced-pluripotent-stem-cells-into-retinal-ganglion-cells
#13
Li Huang, Mengfei Chen, Weizhong Zhang, Xuerong Sun, Bingqian Liu, Jian Ge
Induced pluripotent stem cells (iPSCs) possess the capacity to differentiate into multiple cell types including retinal neurons. Despite substantial progress in the transcriptional regulation of iPSC differentiation process, the efficiency of generation of retinal neurons from iPSCs is still low. In this study, we investigated the role of transcription factor NeuroD1 in the differentiation of iPSCs into retinal neurons. We observed that retrovirus-mediated NeuroD1 overexpression in iPSCs increased the efficiency of neuronal differentiation...
August 1, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28764671/retinoids-anxiety-and-peripartum-depressive-symptoms-among-chinese-women-a-prospective-cohort-study
#14
Yingchun Zeng, Yingtao Li, Huaan Xia, Shenglan Wang, Jingxuan Zhou, Dunjin Chen
BACKGROUND: The current study aimed to investigate whether serum RBP levels can be a key predictor of peripartum depression (PPD). METHODS: This was a prospective cohort study, conducted at a general teaching hospital in South China. Research participants were evaluated at three time points: the third trimester of pregnancy (T1), after delivery at week one (T2), and after delivery week six (T3) using a set of self-reported questionnaires and blood sample assays...
August 1, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28754339/interleukin-1-receptor-knockout-mice-develop-epidermal-cysts-and-show-an-altered-innate-immune-response-following-exposure-to-ultraviolet-b-radiation
#15
Nikhil N Kulkarni, Christopher A Adase, Ling-Juan Zhang, Andrew W Borkowski, Fengwu Li, James A Sanford, Daniel J Coleman, Carlos Aguilera, Arup K Indra, Richard L Gallo
In this study, we observed that mice lacking the interleukin 1 receptor (IL1r(-/-)), or deficient in interleukin 1-beta (IL1-β), developed multiple epidermal cysts after chronic ultraviolet B (UVB) exposure. Cysts that developed in IL1r(-/-) mice were characterized by the presence of the hair follicle marker Sox 9, keratins (K10 and K14) and normal melanocyte distribution and retinoid X receptor α (RXR α) expression. The increased incidence of cysts in IL1r(-/-) mice was associated with less skin inflammation as characterized by decreased recruitment of macrophages, and their skin also maintained epidermal barrier function compared to wild-type mice...
July 25, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28732066/inhibition-of-pulmonary-%C3%AE-carotene-15-15-oxygenase-expression-by-glucocorticoid-involves-ppar%C3%AE
#16
Xiaoming Gong, Raju Marisiddaiah, Lewis P Rubin
β-carotene 15,15'-oxygenase (BCO1) catalyzes the first step in the conversion of dietary provitamin A carotenoids to vitamin A. This enzyme is expressed in a variety of developing and adult tissues, suggesting that its activity may regulate local retinoid synthesis. Vitamin A and related compounds (retinoids) are critical regulators of lung epithelial development, integrity, and injury repair. A balance between the actions of retinoids and glucocorticoids (GCs) promotes normal lung development and, in particular, alveolarization...
2017: PloS One
https://www.readbyqxmd.com/read/28727051/carotenoid-intake-and-scd-genotype-exert-complementary-effects-over-fat-content-and-fatty-acid-composition-in-duroc-pigs
#17
E Henriquez-Rodriguez, R N Pena, A R Seradj, L Fraile, P Christou, M Tor, J Estany
Nutritional and genetic strategies are needed to enhance intramuscular fat (IMF) and MUFA content without altering carcass leanness. Dietary vitamin A restriction has been suggested to specifically promote IMF, whereas a polymorphism of the () gene has shown to specifically increase MUFA. The purpose of this study was to investigate the combined effects of provitamin A (PVA) carotenoid intake and genotype (>) on hepatic retinoid content and on the liver, muscle (LM and gluteus medius [GM]), and subcutaneous fat (SF) content and fatty acid composition...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28720593/vitamin-a-endocrine-tissues-and-hormones-interplay-and-interactions
#18
Julie Brossaud, Veronique Pallet, Jean-Benoit Corcuff
Vitamin A (retinol) is a micronutrient critical for cell proliferation and differentiation. In adults, vitamin A and metabolites such as retinoic acid (RA) play major roles in vision, immune and brain functions, and tissue remodelling and metabolism. This review presents the physiological interactions of retinoids and endocrine tissues and hormonal systems. Two endocrine systems have been particularly studied. In the pituitary, retinoids targets the corticotrophs with a possible therapeutic use in corticotropinomas...
July 18, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28697219/the-role-of-a-natural-mollusk-egg-derived-ingredient-in-facial-appearance
#19
Zoe Diana Draelos
<p>New cosmeceutical ingredients that improve skin appearance are of interest to the dermatologist. Cryptomphalus aspersa is a snail raised on farms in Spain for its mucinous secretions and eggs. These natural products have been demonstrated in vitro to trigger mesenchymal stem cell differentiation, promote dermal fibroblast and keratinocyte migration, prevent keratinocyte aging, prevent oxidative damage, stimulate the extracellular matrix, and regulate MMPs. This 12-week study enrolled 40 male and female subjects age 40-70 years of Fitzpatrick skin types I-IV with moderate to severe facial aging and Rao-Goldman scores of 4-5 who applied an eye and face anti-aging cream twice daily containing a mollusk egg extract...
July 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28696354/a-case-of-aml-characterized-by-a-novel-t-4-15-q31-q22-translocation-that-confers-a-growth-stimulatory-response-to-retinoid-based-therapy
#20
Justin M Watts, Aymee Perez, Lutecia Pereira, Yao-Shan Fan, Geoffrey Brown, Francisco Vega, Kevin Petrie, Ronan T Swords, Arthur Zelent
Here we report the case of a 30-year-old woman with relapsed acute myeloid leukemia (AML) who was treated with all-trans retinoic acid (ATRA) as part of investigational therapy (NCT02273102). The patient died from rapid disease progression following eight days of continuous treatment with ATRA. Karyotype analysis and RNA-Seq revealed the presence of a novel t(4;15)(q31;q22) reciprocal translocation involving the TMEM154 and RASGRF1 genes. Analysis of primary cells from the patient revealed the expression of TMEM154-RASGRF1 mRNA and the resulting fusion protein, but no expression of the reciprocal RASGRF1-TMEM154 fusion...
July 11, 2017: International Journal of Molecular Sciences
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