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retinoid investigation

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https://www.readbyqxmd.com/read/29757674/eicosapentaenoic-acid-induces-dna-demethylation-in-carcinoma-cells-through-a-tet1-dependent-mechanism
#1
Veronica Ceccarelli, Virginia Valentini, Simona Ronchetti, Lorenza Cannarile, Monia Billi, Carlo Riccardi, Laura Ottini, Vincenzo Nicola Talesa, Francesco Grignani, Alba Vecchini
In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions of silenced tumor suppressor genes. Demethylating agents may reverse hypermethylation, thus promoting gene re-expression. Unfortunately, demethylating strategies are not efficient in solid tumor cells. DNA demethylation is mediated by ten-eleven translocation enzymes (TETs). They sequentially convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), which is associated with active transcription; 5-formylcytosine; and finally, 5-carboxylcytosine...
May 14, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29740162/molecular-targets-of-chinese-herbs-a-clinical-study-of-metastatic-colorectal-cancer-based-on-network-pharmacology
#2
Hongxu Zhu, Jian Hao, Yangyang Niu, Dan Liu, Dan Chen, Xiongzhi Wu
Increasing evidence has shown that Chinese herbal medicine (CHM) has promising therapeutic effects in colorectal cancer (CRC); however, the active ingredients and potential targets remain unclear. In this study, we aimed to investigate the relative molecular targets of the Chinese herbs that have been found effective in treating metastatic CRC (mCRC) based on clinical data and network pharmacology. In multivariate analysis CHM resulted an independent prognostic factor. The hazard ratio was 0.103 (95% confidence interval = 0...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29731607/4-amino-2-trifluoromethyl-phenyl-retinate-inhibits-proliferation-invasion-and-migration-of-breast-cancer-cells-by-independently-regulating-crabp2-and-fabp5
#3
Jing Ju, Nan Wang, Jiali Wang, Fanrong Wu, Jinfang Ge, Feihu Chen
Background: 4-Amino-2-trifluoromethyl-phenyl retinate (ATPR), a novel retinoid derivative, inhibits proliferation and induces differentiation in many cancer cells. In this study, the inhibitory effects of ATPR on the proliferation, invasion, and migration of breast cancer (BC) cells, and the relationship between ATPR and the expression of the intracellular lipid-binding proteins CRABP2 and FABP5 were investigated. Methods: CRABP2 and FABP5 expression was evaluated in infiltrating breast-infiltrating ductal carcinoma(BIDC) and benign breast fibroma (BBF) by immunohistochemistry and in MCF-7, MDA-MB-231, MDA-MB-435, and MDA-MB-453 cells by immunofluorescence...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29721989/the-retinol-binding-protein-receptor-2-rbpr2-is-required-for-photoreceptor-survival-and-visual-function-in-the-zebrafish
#4
Glenn P Lobo, Gayle Pauer, Joshua H Lipschutz, Stephanie A Hagstrom
Vitamin A/retinol (ROL) and its metabolites (retinoids) play critical roles in eye development and photoreception. Short-term dietary vitamin A deficiency (VAD) manifests clinically as night blindness, while prolonged VAD is known to cause retinal pigment epithelium (RPE) and photoreceptor degeneration. Therefore, sustained uptake of dietary vitamin A, for ocular retinoid production, is essential for photoreceptor health and visual function. The mechanisms influencing the uptake, storage, and supply of dietary vitamin A, for ocular retinoid production, however, are not fully understood...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29703210/telomerase-regulation-by-the-long-non-coding-rna-h19-in-human-acute-promyelocytic-leukemia-cells
#5
Joëlle El Hajj, Eric Nguyen, Qingyuan Liu, Claire Bouyer, Eric Adriaenssens, George Hilal, Evelyne Ségal-Bendirdjian
BACKGROUND: Since tumor growth requires reactivation of telomerase (hTERT), this enzyme is a challenging target for drug development. Therefore, it is of great interest to identify telomerase expression and activity regulators. Retinoids are well-known inducers of granulocytic maturation associated with hTERT repression in acute promyelocytic leukemia (APL) blasts. In a maturation-resistant APL cell line, we have previously identified a new pathway of retinoid-induced hTERT transcriptional repression independent of differentiation...
April 27, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29696141/enhancing-understanding-of-the-visual-cycle-by-applying-crispr-cas9-gene-editing-in-zebrafish
#6
REVIEW
Rebecca Ward, Husvinee Sundaramurthi, Valeria Di Giacomo, Breandán N Kennedy
During the vertebrate visual cycle, all- trans -retinal is exported from photoreceptors to the adjacent RPE or Müller glia wherein 11- cis -retinal is regenerated. The 11- cis chromophore is returned to photoreceptors, forming light-sensitive visual pigments with opsin GPCRs. Dysfunction of this process perturbs phototransduction because functional visual pigment cannot be generated. Mutations in visual cycle genes can result in monogenic inherited forms of blindness. Though key enzymatic processes are well characterized, questions remain as to the physiological role of visual cycle proteins in different retinal cell types, functional domains of these proteins in retinoid biochemistry and in vivo pathogenesis of disease mutations...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29666772/frizzled-related-proteins-4-sfrp4-rs1802073g-allele-predicts-the-elevated-serum-lipid-levels-during-acitretin-treatment-in-psoriatic-patients-from-hunan-china
#7
Xingchen Zhou, Wu Zhu, Minxue Shen, Yijing He, Cong Peng, Yehong Kuang, Juan Su, Shuang Zhao, Xiang Chen, Wangqing Chen
Background: Acitretin is a second-generation synthetic retinoid, and is widely used for treating the severe psoriasis vulgaris. However, it should be chosen with caution for its cardiovascular risk, and it is reported that acitretin may increase the serum lipids. The purpose of this study is to investigate the relationship between the Frizzled-related proteins 4 (SFRP4) rs1802073 polymorphism and the changes of serum lipids in Chinese psoriatic patients during the treatment with acitretin...
2018: PeerJ
https://www.readbyqxmd.com/read/29655815/evidence-for-retinoic-acid-involvement-in-the-regulation-of-vitellogenesis-in-the-fresh-water-edible-crab-oziotelphusa-senex-senex
#8
B P Girish, C H Swetha, M Srilatha, M Hemalatha, P Sreenivasula Reddy
The possible involvement of 13-cis retinoic acid (CRA) in the regulation of ovarian development in Oziotelphusa senex senex was investigated. Injection of CRA, into avitellogenic crabs significantly increased ovarian index, oocyte diameter and ovarian vitellogenin levels. Injection of CRA also resulted in a significant increase in the secretory rates of mandibular organs and Y-organs and circulatory levels of the methyl farnesoate and ecdysteroids. Further, administration of CRA into avitellogenic crabs produced higher amounts of Retinoid X Receptor, Ecdysteroid Receptor, E75 and vitellogenin mRNAs in the hepatopancreas...
April 12, 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29625456/local-s100a8-levels-correlate-with-recurrence-of-experimental-autoimmune-uveitis-and-promote-pathogenic-t-cell-activity
#9
Juan Yun, Tong Xiao, Lei Zhou, Roger W Beuerman, Juanjuan Li, Yuan Zhao, Amir Hadayer, Xiaomin Zhang, Deming Sun, Henry J Kaplan, Hui Shao
Purpose: To investigate the role of damage-associated molecular patterns (DAMPs) in recurrent experimental autoimmune uveitis (EAU). Methods: Recurrent EAU was induced in Lewis rats by interphotoreceptor retinoid-binding protein (IRBP) R16-peptide specific T cells (tEAU). Aqueous humor and serum samples were kinetically collected and DAMPs examined by quantitative proteomics, Western blot analysis, and ELISA. tEAU rats were treated with S100 inhibitor paquinimod followed by disease evaluation...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29624848/autofluorescence-based-optical-biopsy-an-effective-diagnostic-tool-in-hepatology
#10
Anna Cleta Croce, Andrea Ferrigno, Giovanni Bottiroli, Mariapia Vairetti
Autofluorescence emission of liver tissue depends on the presence of endogenous biomolecules able to fluoresce under suitable light excitation. Overall autofluorescence emission contains much information of diagnostic value, because it is the sum of individual autofluorescence contributions from fluorophores involved in metabolism, for example NAD(P)H, flavins, lipofuscins, retinoids, porphyrins, bilirubin and lipids, or in structural architecture, for example fibrous proteins, in close relationship with normal, altered or diseased conditions of the liver...
April 6, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29621670/characterization-and-comparison-of-transcriptional-activities-of-the-retinoid-x-receptors-by-various-organotin-compounds-in-three-prosobranch-gastropods-thais-clavigera-nucella-lapillus-and-babylonia-japonica
#11
Hiroshi Urushitani, Yoshinao Katsu, Hiroyuki Kagechika, Ana C A Sousa, Carlos M Barroso, Yasuhiko Ohta, Hiroaki Shiraishi, Taisen Iguchi, Toshihiro Horiguchi
Two cDNAs of RXR were isolated, for the first time, from the ivory shell, Babylonia japonica, and the transcriptional activities were tested in vitro to compare with other gastropod (Thais clavigera and Nucella lapillus) RXR isoforms. The transcriptional activities of all of these RXR isoforms were significantly induced by mammalian RXR agonist, 9-cis retinoic acid (9cRA). The transcriptional activity of T. clavigera RXR-1 was also examined by using 9cRA and 16 organotin compounds, and significant ligand-dependent transactivations were observed by 9cRA and 5 organotins (tributyltin (TBT), tetrabutyltin (TeBT), tripropyltin (TPrT), tricyclohexyltin (TcHT) and triphenyltin (TPhT))...
March 26, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29603591/phase-i-study-of-vorinostat-in-combination-with-isotretinoin-in-patients-with-refractory-recurrent-neuroblastoma-a-new-approaches-to-neuroblastoma-therapy-nant-trial
#12
Navin Pinto, Steven G DuBois, Araz Marachelian, Scott J Diede, Agne Taraseviciute, Julia L Glade Bender, Denice Tsao-Wei, Susan G Groshen, Joel M Reid, Daphne A Haas-Kogan, C Patrick Reynolds, Min H Kang, Meredith S Irwin, Margaret E Macy, Judith G Villablanca, Katherine K Matthay, Julie R Park
BACKGROUND: Vorinostat combined with retinoids produces additive antitumor effects in preclinical studies of neuroblastoma. Higher systemic exposures of vorinostat than achieved in pediatric phase I trials with continuous daily dosing are necessary for in vivo increased histone acetylation and cytotoxic activity. We conducted a phase I trial in children with relapsed/refractory neuroblastoma to determine the maximum tolerated dose (MTD) of vorinostat on an interrupted schedule, escalating beyond the previously identified pediatric MTD...
March 30, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29599914/serum-micrornas-as-predictors-of-risk-for-non-muscle-invasive-bladder-cancer
#13
Jie Lian, Shu-Hong Lin, Yuanqing Ye, David W Chang, Maosheng Huang, Colin P Dinney, Xifeng Wu
MicroRNAs (miRNAs) are implicated in the development of nearly all cancers and may function as promising biomarkers for early detection, diagnosis and prognosis. We sought to investigate the role of serum miRNAs as potential diagnostic biomarkers or biomarkers of risk for early-stage bladder cancer. First, we profiled global serum miRNAs in a pilot set of 10 non-muscle invasive bladder cancer (NMIBC) cases and 10 healthy controls matched on age, gender and smoking status. Eighty nine stably detectable miRNAs were selected for further testing and quantification by high-throughput Taqman analysis using the Fluidigm BioMark HD System to assess their association with NMIBC risk in both discovery and validation sets totaling 280 cases and 278 controls...
March 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29587617/retinoic-acid-pathway-regulation-of-vascular-endothelial-growth-factor-in-ovine-amnion
#14
Cecilia Y Cheung, Debra F Anderson, Marion Rouzaire, Loïc Blanchon, Vincent Sapin, Robert A Brace
Vascular endothelial growth factor (VEGF) has been proposed as an important regulator of amniotic fluid absorption across the amnion into the fetal vasculature on the surface of the placenta. However, the activators of VEGF expression and action in the amnion have not been identified. Using the pregnant sheep model, we aimed to investigate the presence of the retinoic acid (RA) pathway in ovine amnion and to determine its effect on VEGF expression. Further, we explored relationships between RA receptors and VEGF and tested the hypothesis that RA modulates intramembranous absorption (IMA) through induction of amnion VEGF in sheep fetuses subjected to altered IMA rates...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29572578/crucial-role-of-p2x-7-receptor-for-effector-t-cell-activation-in-experimental-autoimmune-uveitis
#15
Atsunobu Takeda, Hisakata Yamada, Eiichi Hasegawa, Mitsuru Arima, Shoji Notomi, Sayaka Myojin, Takeru Yoshimura, Toshio Hisatomi, Hiroshi Enaida, Ryoji Yanai, Kazuhiro Kimura, Tatsuro Ishibashi, Koh-Hei Sonoda
PURPOSE: To investigate the roles of P2X7 receptors (P2RX7) in the pathogenesis of experimental autoimmune uveoretinitis (EAU). STUDY DESIGN: Experimental. METHODS: Either wild-type (P2rx7+/+ ) or P2rx7-deficient (P2rx7-∕- ) mice were immunized with interphotoreceptor retinoid-binding protein (IRBP) peptide 1-20. Severity of EAU was evaluated clinically and histopathologically. The induction of IRBP-specific proliferation and cytokines in draining lymph nodes was assessed by enzyme-linked immunosorbent assays (ELISA)...
March 23, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29571629/partial-retinal-photoreceptor-loss-in-a-transgenic-mouse-model-associated-with-reduced-levels-of-interphotoreceptor-retinol-binding-protein-irbp-rbp3
#16
Yi-Hsia Liu, Clare Corbett, Izabela P Klaska, Kimmo Makinen, John M Nickerson, Richard J Cornall, Lucia Kuffova, John V Forrester
Organ-specific transgenic membrane expression of hen egg lysozyme (HEL) as a "neo-self antigen" has been used in several models to study immunological tolerance. In this study we report the changes which occur in the B10.BR mouse retina when membrane-bound HEL is expressed in photoreceptors under the control of the promoter for interphotoreceptor retinoid binding protein (IRBP, RBP3). On direct clinical examination of the single transgenic (sTg-IRBP:HEL) mouse fundus, a low-level increase in retinal degeneration compared to non-transgenic controls was observed, presenting as drusenoid deposits and occasional small patches of atrophy...
March 20, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29568857/accelerated-inflammation-and-oxidative-stress-induced-by-lps-in-acute-lung-injury-%C3%AE-nhibition-by-st1926
#17
Zewu Dong, Yufang Yuan
Bioavailable and less toxic synthetic retinoids, such as the atypical adamantyl retinoid ST1926, have been well developed and investigated in clinical trials for many diseases. The aim of our study was to explore the role of ST1926 in lipopolysaccharide (LPS)-induced acute lung injury (ALI) and to reveal the possible molecular mechanism. Mice were treated with LPS to induce acute lung injury followed by ST1926 administration. After LPS induction, mice administered with ST1926 showed lower inflammation infiltration in bronchoalveolar lavage (BAL) fluid, and pro-inflammatory cytokines, including interleukin-1β (IL-1β), IL-18, IL-6 and tumor necrosis factor-α (TNF-α) in serum and lung tissue samples obtained from mice...
March 19, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29558965/regulation-by-fsh-of-the-dynamic-expression-of-retinol-binding-protein-4-in-the-mouse-ovary
#18
Yanwen Jiang, Yun Zhao, Shuxiong Chen, Lu Chen, Chunjin Li, Xu Zhou
BACKGROUND: Ovarian retinoid homeostasis plays an important role in the physiological function of the ovary. Retinol-binding protein 4 (RBP4) acts as the mediator for the systemic and intercellular transport of retinol and is heavily involved in cellular retinol influx, efflux, and exchange. However, the expression patterns and regulatory mechanisms of Rbp4 in the ovary remain unclear. METHODS: The expression pattern of ovarian Rbp4 was examined in immature mice during different developmental stages and in adult mice during different stages of the estrous cycle...
March 20, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29547020/comparative-study-of-ablative-fractional-photothermolysis-versus-topical-retinoid-cream-in-the-treatment-of-idiopathic-guttate-hypomelanosis
#19
Won Seon Koh, Jeong Eun Kim, Young Suck Ro, Joo Yeon Ko
BACKGROUND: Despite various treatments attempts, no prospective studies have compared the different therapeutic modalities for treatment of idiopathic guttate hypomelanosis (IGH). This study aimed to compare the efficacy of CO2 fractional laser (CO₂FL), Er:YAG fractional laser (EYFL), and 0.025% topical tretinoin for treating IGH. MATERIALS AND METHODS: A total of 122 lesions were analyzed from 18 patients (mean age, 70.00 ± 20.00 years). Treatment outcome evaluations included the visual analog scale (VAS) to assess lesion severity, investigator's global assessment (IGA) to assess the extent of improvement, and patient's satisfaction score (PSS)...
March 16, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29545199/imiquimod-induced-psoriasis-like-skin-lesions-do-not-accelerate-atherosclerosis-in-low-density-lipoprotein-receptor-deficient-mice
#20
Marie Madsen, Peter Riis Hansen, Lars Bo Nielsen, Renata Martins Cardoso, Miranda van Eck, Tanja Xenia Pedersen
Psoriasis is a chronic inflammatory skin disorder associated with several comorbidities including atherosclerosis. Disease mechanisms that may affect both psoriasis and atherosclerosis include activation of T helper 1 and T helper 17 cells. Imiquimod application is an established mouse model of psoriasis-like skin inflammation. The cardiac glycoside digoxin inhibits the master transcription factor of T helper 17 differentiation, retinoid acid receptor-related orphan nuclear receptor γt, and attenuates interleukin-17-dependent pathologies in mice...
March 12, 2018: American Journal of Pathology
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