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Major depression and mortality

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https://www.readbyqxmd.com/read/28423154/association-of-mental-disorders-and-related-medication-use-with-risk-for-major-osteoporotic-fractures
#1
James M Bolton, Suzanne N Morin, Sumit R Majumdar, Jitender Sareen, Lisa M Lix, Helena Johansson, Anders Odén, Eugene V McCloskey, John A Kanis, William D Leslie
Importance: Osteoporotic fractures are a leading cause of disability, costs, and mortality. FRAX is a tool used to assess fracture risk in the general population. Mental disorders and medications to treat them have been reported to adversely affect bone health, but, to date, they have not been systematically studied in relation to osteoporotic fractures. Objective: To examine the association of mental disorders and psychotropic medication use with osteoporotic fracture risk in routine clinical practice...
April 19, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28415979/behavioral-activation-for-smoking-cessation-and-mood-management-following-a-cardiac-event-results-of-a-pilot-randomized-controlled-trial
#2
Andrew M Busch, Erin M Tooley, Shira Dunsiger, Elizabeth A Chattillion, John Fani Srour, Sherry L Pagoto, Christopher W Kahler, Belinda Borrelli
BACKGROUND: Smoking cessation following hospitalization for Acute Coronary Syndrome (ACS) significantly reduces subsequent mortality. Depressed mood is a major barrier to cessation post-ACS. Although existing counseling treatments address smoking and depression independently in ACS patients, no integrated treatment addresses both. We developed an integrated treatment combining gold standard cessation counseling with behavioral activation-based mood management; Behavioral Activation Treatment for Cardiac Smokers (BAT-CS)...
April 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28414583/improved-depressive-symptoms-in-adults-with-schizophrenia-during-a-smoking-cessation-attempt-with-varenicline-and-behavioral-therapy
#3
Corinne Cather, Susanne Hoeppner, Gladys Pachas, Sarah Pratt, Eric Achtyes, Kristina M Cieslak, A Eden Evins
OBJECTIVE: Smoking prevalence rates are elevated in individuals with schizophrenia spectrum disorders (SSD) compared with the general population, with attendant disproportionate smoking-related morbidity and mortality. Pharmacotherapies that improve abstinence rates in this population are underutilized, partly due to concerns about neuropsychiatric safety, particularly for those with comorbid depression or prior suicide attempt. Prospective assessment of the psychiatric safety profile of varenicline in those with SSD is needed...
April 17, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28409519/off-line-analysis-of-electro-anatomical-mapping-in-ventricular-arrhythmias
#4
Daniele Muser, Jackson J Liang, Pasquale Santangeli
Sudden cardiac death due to ventricular tachycardia (VT) is a major health issue in patients with structural heart disease and depressed ejection fraction. If from one side, implantable cardioverter defibrillator (ICD) therapy has significantly improved survival of these patients, on the other hand, it has led to frequent ICD shocks as an emerging problem, being associated with poor quality of life, frequent hospitalizations and increased mortality. Scar-related reentry due to the coexistence of surviving myocardial fibers within fibrotic tissue is the most common mechanism subtending VT both in ischemic and non-ischemic cardiomyopathies...
April 12, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28401273/suicide-mortality-among-male-veterans-discharged-from-veterans-health-administration-acute-psychiatric-units-from-2005-to-2010
#5
Peter C Britton, Kipling M Bohnert, Mark A Ilgen, Cathleen Kane, Brady Stephens, Wilfred R Pigeon
PURPOSE: The purpose of this study was to calculate suicide rates and identify correlates of risk in the year following discharge from acute Veterans Health Administration psychiatric inpatient units among male veterans discharged from 2005 to 2010 (fiscal years). METHODS: Suicide rates and standardized mortality ratios were calculated. Descriptive analyses were used to describe suicides and non-suicides and provide base rates for interpretation, and unadjusted and adjusted proportional hazard models were used to identify correlates of suicide...
April 11, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28396255/the-recent-progress-in-animal-models-of-depression
#6
REVIEW
Qingzhong Wang, Matthew A Timberlake, Kevin Prall, Yogesh Dwivedi
Major depression disorder (MDD) is a debilitating mental illness with significant morbidity and mortality. Despite the growing number of studies that have emerged, the precise underlying mechanisms of MDD remain unknown. When studying MDD, tissue samples like peripheral blood or post-mortem brain samples are used to elucidate underlying mechanisms. Unfortunately, there are many uncontrollable factors with such samples such as medication history, age, time after death before post-mortem tissue was collected, age, sex, race, and living conditions...
April 8, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28393713/immune-system-modulators-with-antidepressant-effects-evidence-from-animal-models
#7
Helena M Abelaira, Amanda L Maciel, João Quevedo, Gislaine Réus
BACKGROUND: Major depressive disorder (MDD) is associated with high mortality and morbidity rates, and currently, approximately 340 million people worldwide suffer from depression at some point in life. In view of the growing socio-economic and clinical impact, several studies have focused on the etiopathology of MDD, suggesting that not only the monoaminergic system but also other brain mechanisms may be involved in the pathophysiology of MDD. Recent studies have shown a link between inflammation and MDD and have also demonstrated that antidepressants and anti-inflammatory drugs can act to reduce inflammation, thereby improving depressive symptoms...
April 4, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28393267/charting-the-perfect-storm-emerging-biological-interfaces-between-stress-and-stroke
#8
REVIEW
G Kronenberg, J Schöner, C Nolte, A Heinz, M Endres, Karen Gertz
A growing body of evidence demonstrates that psychosocial stress is an important and often underestimated risk factor for cardiovascular disease such as myocardial infarction and stroke. In this article, we map out major biological interfaces between stress, stress-related psychiatric disorders, and stroke, placing special emphasis on the fact that stress and psychiatric disorders may be both cause and consequence of cardiovascular disease. Apart from high-risk lifestyle habits such as smoking and lack of exercise, neuroendocrine dysregulation, alterations of the hemostatic system, increased oxidative stress, and inflammatory changes have been implicated in stress-related endothelial dysfunction...
April 9, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28378157/adherence-and-persistence-across-antidepressant-therapeutic-classes-a-retrospective-claims-analysis-among-insured-us-patients-with-major-depressive-disorder-mdd
#9
Katelyn R Keyloun, Ryan N Hansen, Zsolt Hepp, Patrick Gillard, Michael E Thase, Emily Beth Devine
BACKGROUND: Adherence and persistence to therapy, or how well a patient follows provider directions on frequency and time to discontinuation of prescribed medications, is associated with positive health outcomes, including decreased healthcare costs and patient mortality. A clear literature gap exists assessing adherence and persistence to antidepressants (ADs) in the major depressive disorder (MDD) population at clinically relevant time points and at the therapeutic class level. OBJECTIVE: This study assessed adherence and persistence to specific ADs, therapeutic classes, and AD therapy overall at multiple time points among US individuals from commercial, Medicare supplemental, and Medicaid insurance plans...
April 4, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28377390/translating-the-who-25%C3%A3-25-goals-into-a-uk-context-the-promise-modelling-study
#10
Linda J Cobiac, Peter Scarborough
OBJECTIVE: Model the impact of targets for obesity, diabetes, raised blood pressure, tobacco use, salt intake, physical inactivity and harmful alcohol use, as outlined in the Global Non-Communicable Disease Action Plan 2013-2020, on mortality and morbidity in the UK population. DESIGN: Dynamic population modelling study. SETTING: UK population. PARTICIPANTS: Not available. MAIN OUTCOME MEASURES: Mortality and morbidity (years lived with disability) from non-communicable diseases (NCDs) that are averted or delayed...
April 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28366738/the-heartbreak-of-depression-psycho-cardiac-coupling-in-myocardial-infarction
#11
REVIEW
John P Headrick, Jason N Peart, Boris P Budiono, David H K Shum, David L Neumann, Nicolas J C Stapelberg
Ample evidence identifies strong links between major depressive disorder (MDD) and both risk of ischemic or coronary heart disease (CHD) and resultant morbidity and mortality. The molecular mechanistic bases of these linkages are poorly defined. Systemic factors linked to MDD, including vascular dysfunction, atherosclerosis, obesity and diabetes, together with associated behavioral changes, all elevate CHD risk. Nonetheless, experimental evidence indicates the myocardium is also directly modified in depression, independently of these factors, impairing infarct tolerance and cardioprotection...
March 31, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28366336/sleep-duration-is-associated-with-survival-in-advanced-cancer-patients
#12
Kevin P Collins, David A Geller, Michael Antoni, Drew Michael Donnell, Allan Tsung, James W Marsh, Lora Burke, Frank Penedo, Lauren Terhorst, Thomas W Kamarck, Anna Greene, Daniel J Buysse, Jennifer L Steel
OBJECTIVE: Sleep problems have been linked to increased risk of mortality in the general population. Limited evidence suggests similar relationships among people diagnosed with cancer. The aims of the present study were to investigate the type and rates of sleep problems in advanced cancer patients and examine whether sleep problems are associated with survival. METHODS: A prospective study of 292 patients with advanced cancers affecting the hepatobiliary and pancreatic systems were administered a battery of questionnaires measuring sociodemographic information, sleep, and depression...
April 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28365468/intelligence-and-neuroticism-in-relation-to-depression-and-psychological-distress-evidence-from-two-large-population-cohorts
#13
L B Navrady, S J Ritchie, S W Y Chan, D M Kerr, M J Adams, E H Hawkins, D Porteous, I J Deary, C R Gale, G D Batty, A M McIntosh
BACKGROUND: Neuroticism is a risk factor for selected mental and physical illnesses and is inversely associated with intelligence. Intelligence appears to interact with neuroticism and mitigate its detrimental effects on physical health and mortality. However, the inter-relationships of neuroticism and intelligence for major depressive disorder (MDD) and psychological distress has not been well examined. METHODS: Associations and interactions between neuroticism and general intelligence (g) on MDD, self-reported depression, and psychological distress were examined in two population-based cohorts: Generation Scotland: Scottish Family Health Study (GS:SFHS, n=19,200) and UK Biobank (n=90,529)...
January 17, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28365466/early-clinical-predictors-and-correlates-of-long-term-morbidity-in-bipolar-disorder
#14
G Serra, A Koukopoulos, L De Chiara, A E Koukopoulos, G Sani, L Tondo, P Girardi, D Reginaldi, R J Baldessarini
OBJECTIVES: Identifying factors predictive of long-term morbidity should improve clinical planning limiting disability and mortality associated with bipolar disorder (BD). METHODS: We analyzed factors associated with total, depressive and mania-related long-term morbidity and their ratio D/M, as %-time ill between a first-lifetime major affective episode and last follow-up of 207 BD subjects. Bivariate comparisons were followed by multivariable linear regression modeling...
February 21, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28362646/the-de-winter-ecg-pattern-morphology-and-accuracy-for-diagnosing-acute-coronary-occlusion-systematic-review
#15
Niall P Morris, Richard Body
The De Winter ECG pattern has been reported to indicate acute left anterior descending coronary artery occlusion and is often considered to be an 'ST elevation myocardial infarction (STEMI) equivalent'. We aimed to investigate the morphology of the 'De Winter ECG pattern' and evaluate the test characteristics of the De Winter pattern for the diagnosis of acute coronary occlusion. We identified papers through the Medline, EMBASE and COCHRANE databases and screened for bias using QUADAS-2. First, measurements were recorded from every ECG reported in the literature and aggregated...
March 30, 2017: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/28357682/quality-of-life-independently-predicts-long-term-mortality-but-not-vascular-events-the-northern-manhattan-study
#16
John W Liang, Ying Kuen Cheung, Joshua Z Willey, Yeseon P Moon, Ralph L Sacco, Mitchell S V Elkind, Mandip S Dhamoon
PURPOSE: Cardiovascular disease is a major contributor to morbidity and mortality, and prevention relies on accurate identification of those at risk. Studies of the association between quality of life (QOL) and mortality and vascular events incompletely accounted for depression, cognitive status, social support, and functional status, all of which have an impact on vascular outcomes. We hypothesized that baseline QOL is independently associated with long-term mortality in a large, multi-ethnic urban cohort...
March 29, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28351880/preventing-peer-violence-against-children-methods-and-baseline-data-of-a-cluster-randomized-controlled-trial-in-pakistan
#17
Judith McFarlane, Rozina Karmaliani, Hussain Maqbool Ahmed Khuwaja, Saleema Gulzar, Rozina Somani, Tazeen Saeed Ali, Yasmeen H Somani, Shireen Shehzad Bhamani, Ryan D Krone, Rene M Paulson, Atta Muhammad, Rachel Jewkes
BACKGROUND: Violence against and among children is a global public health problem that annually affects 50% of youth worldwide with major impacts on child development, education, and health including increased probability of major causes of morbidity and mortality in adulthood. It is also associated with the experience of and perpetration of later violence against women. The aim of this article is to describe the intervention, study design, methods, and baseline findings of a cluster randomized controlled trial underway in Pakistan to evaluate a school-based play intervention aiming to reduce peer violence and enhance mental health...
March 24, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28340040/impaired-ability-to-grow-colonies-of-endothelial-stem-cells-could-be-the-mechanism-explaining-the-high-cardiovascular-morbidity-mortality-of-patients-with-depression
#18
Blum Arnon, Pastukh Nina, Zaroura Imad, Jonathan Rotem, Farhat Kamal
Background: Subjects with depression are more prone to develop cardiovascular complications. Severity of depression is associated with higher rates of cardiovascular mortality and morbidity. Several mechanisms were suggested including accelerated atherosclerosis, alteration of the cardiac autonomic response with a decrease in heart rate variability. There is evidence that circulating endothelial progenitor cells (EPCs) are decreased in patients with major depression. Our hypothesis was that patients with depression would have an impaired ability to build colonies of endothelial progenitor cells...
March 9, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28321191/palmitoylethanolamide-reduces-neuropsychiatric-behaviors-by-restoring-cortical-electrophysiological-activity-in-a-mouse-model-of-mild-traumatic-brain-injury
#19
Francesca Guida, Serena Boccella, Monica Iannotta, Danilo De Gregorio, Catia Giordano, Carmela Belardo, Rosaria Romano, Enza Palazzo, Maria A Scafuro, Nicola Serra, Vito de Novellis, Francesco Rossi, Sabatino Maione, Livio Luongo
Traumatic brain injury (TBI) represents a major public health problem, which is associated with neurological dysfunction. In severe or moderate cases of TBI, in addition to its high mortality rate, subjects may encounter diverse behavioral dysfunctions. Previous reports suggest that an association between TBI and chronic pain syndromes tends to be more common in patients with mild forms of brain injury. Despite causing minimal brain damage, mild TBI (mTBI) often leads to persistent psychologically debilitating symptoms, which can include anxiety, various forms of memory and learning deficits, and depression...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28319269/withdrawn-trimetazidine-for-stable-angina
#20
REVIEW
Agustín Ciapponi, Rudolf Pizarro, Jeff Harrison
BACKGROUND: Patients with stable angina not controlled by monotherapy with nitrates, beta blockers, or calcium channel blockers are often treated with combinations of these drugs. There may be adverse effects from, or contraindications to, the use of combinations. In low risk groups, medical treatment appears to be as good an option as percutaneous transluminal coronary angioplasty in terms of averting myocardial infarction, death, or subsequent revascularization. Revascularization procedures are too costly or inaccessible for many patients in developing countries therefore effective and safe medical treatment is needed...
March 20, 2017: Cochrane Database of Systematic Reviews
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