Pasquale D'Acunzo, Elentina K Argyrousi, Jonathan M Ungania, Yohan Kim, Steven DeRosa, Monika Pawlik, Chris N Goulbourne, Ottavio Arancio, Efrat Levy
BACKGROUND: Hypometabolism tied to mitochondrial dysfunction occurs in the aging brain and in neurodegenerative disorders, including in Alzheimer's disease, in Down syndrome, and in mouse models of these conditions. We have previously shown that mitovesicles, small extracellular vesicles (EVs) of mitochondrial origin, are altered in content and abundance in multiple brain conditions characterized by mitochondrial dysfunction. However, given their recent discovery, it is yet to be explored what mitovesicles regulate and modify, both under physiological conditions and in the diseased brain...
April 14, 2024: Molecular Neurodegeneration