keyword
https://read.qxmd.com/read/33813829/melatonin-as-an-antiepileptic-molecule-therapeutic-implications-via-neuroprotective-and-inflammatory-mechanisms
#1
JOURNAL ARTICLE
Enes Akyuz, Irem Kullu, Alina Arulsamy, Mohd Farooq Shaikh
Epilepsy is a result of unprovoked, uncontrollable, and repetitive outburst of abnormal and excessive electrical discharges, known as seizures, in the neurons. Epilepsy is a devastating neurological condition that affects 70 million people globally. Unfortunately, only two-thirds of epilepsy patients respond to antiepileptic drugs while others become drug resistant and may be more prone to epilepsy comorbidities such as SUDEP. Oxidative stress, mitochondrial dysfunction, imbalance in the excitatory and inhibitory neurotransmitters, and neuroinflammation are some of the common pathologies of neurological disorders and epilepsy...
April 4, 2021: ACS Chemical Neuroscience
https://read.qxmd.com/read/33179848/novel-complex-of-cosmetic-ingredients-with-promising-action-in-preventing-hair-loss-and-follicular-aging-through-mechanism-involving-enrichment-of-wnt-signaling-mitochondrial-activity-and-stem-cells-maintenance
#2
JOURNAL ARTICLE
Mamy Honda Igarashi, Sheila Gomes da Silva, Maurizio Mercuri, Flávia Macedo de Oliveira Neves Zuardi, Gustavo Facchini, Gustavo Henrique da Silva, Ana Lucia Tabarini Alves Pinheiro, Samara Eberlin
BACKGROUND: Mechanisms involved in hair metabolism are diverse, and the availability of ingredients that normalize dysfunctions or mitigate the effects of extrinsic stress suffered daily is greatly desired by consumers to improve the aesthetic appearance of hair. AIMS: In this work, we carried out a preclinical exploratory approach to evaluate the effects of a complex of nanoencapsulated active ingredients (AcPi), as well as a cosmetic formulation containing AcPi (ShPi and HtPi) in mechanisms involving hair loss and follicular aging...
November 12, 2020: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/25529328/silencing-mir-106b-improves-palmitic-acid-induced-mitochondrial-dysfunction-and-insulin-resistance-in-skeletal-myocytes
#3
JOURNAL ARTICLE
Ying Zhang, Ya-Ping Zhao, Yuan-Fu Gao, Zhong-Min Fan, Meng-Yuan Liu, Xiao-Yi Cai, Zheng-Kun Xia, Chun-Lin Gao
MicroRNA‑106b (miR‑106b) is reported to correlate closely with skeletal muscle insulin resistance. In the current study the effect of miR‑106b on palmitic acid (PA)‑induced mitochondrial dysfunction and insulin resistance was investigated in C2C12 myotubes via the silencing of miR‑106b. MiR‑106b expression was increased under PA treatment, while miR‑106b loss of function improved insulin sensitivity by upregulating its target mitofusin‑2 (Mfn2) in C2C12 myocytes. Furthermore, miR‑106b loss of function partly improved mitochondrial morphological lesions and increased the levels of mitochondial DNA and intracellular adenosine triphosphate that had been impaired by PA exposure in C2C12 myocytes...
May 2015: Molecular Medicine Reports
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