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Rostral migratory stream

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https://www.readbyqxmd.com/read/28725659/explant-methodology-for-analyzing-neuroblast-migration
#1
Kirsty J Dixon, Alisa Turbic, Ann M Turnley, Daniel J Liebl
The subventricular zone (SVZ) in the mammalian forebrain contains stem/progenitor cells that migrate through the rostral migratory stream (RMS) to the olfactory bulb throughout adulthood. SVZ-derived explant cultures provide a convenient method to assess factors regulating the intermediary stage of neural stem/progenitor cell migration. Here, we describe the isolation of SVZ-derived RMS explants from the neonatal mouse brain, and the conditions required to culture and evaluate their migration.
May 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/28687665/mutation-of-the-%C3%AE-tubulin-tuba1a-leads-to-straighter-microtubules-and-perturbs-neuronal-migration
#2
Richard Belvindrah, Kathiresan Natarajan, Preety Shabajee, Elodie Bruel-Jungerman, Jennifer Bernard, Marie Goutierre, Imane Moutkine, Xavier H Jaglin, Mythili Savariradjane, Theano Irinopoulou, Jean-Christophe Poncer, Carsten Janke, Fiona Francis
Brain development involves extensive migration of neurons. Microtubules (MTs) are key cellular effectors of neuronal displacement that are assembled from α/β-tubulin heterodimers. Mutation of the α-tubulin isotype TUBA1A is associated with cortical malformations in humans. In this study, we provide detailed in vivo and in vitro analyses of Tuba1a mutants. In mice carrying a Tuba1a missense mutation (S140G), neurons accumulate, and glial cells are dispersed along the rostral migratory stream in postnatal and adult brains...
August 7, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28669915/magnetic-resonance-imaging-of-odorant-activity-dependent-migration-of-neural-precursor-cells-and-olfactory-bulb-growth
#3
Nikorn Pothayee, Diana M Cummings, Timothy J Schoenfeld, Stephen Dodd, Heather A Cameron, Leonardo Belluscio, Alan P Koretsky
Neural progenitors or neuroblasts are produced by precursor cells in the subventricular zone (SVZ) and migrate along the rostral migratory stream (RMS) to the olfactory bulbs (OB) throughout life. In the OB, these adult born neurons either die or replace existing olfactory interneurons, playing a critical role in the stabilization of OB circuitry. Although several aspects of the addition of new neurons into the OB have been studied, it is unclear whether long-distance activity from the OB can regulate the influx of migrating neuroblasts along the RMS...
June 30, 2017: NeuroImage
https://www.readbyqxmd.com/read/28596977/different-forms-of-structural-plasticity-in-the-adult-olfactory-bulb
#4
REVIEW
Delphine Hardy, Armen Saghatelyan
The adult olfactory bulb (OB) continuously receives new interneurons that integrate into the functional neuronal network and that play an important role in odor information processing and olfactory behavior. Adult neuronal progenitors are derived from neural stem cells in the subventricular zone (SVZ) bordering the lateral ventricle. They migrate long distances along the rostral migratory stream (RMS) toward the OB where they differentiate into interneurons, mature, and establish synapses with tufted or mitral cells (MC), the principal neurons in the OB...
2017: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/28567003/evidence-of-a-cell-surface-role-for-hsp90-complex-proteins-mediating-neuroblast-migration-in-the-subventricular-zone
#5
Leo M Miyakoshi, Diego Marques-Coelho, Luiz E R De Souza, Flavia R S Lima, Vilma R Martins, Silvio M Zanata, Cecilia Hedin-Pereira
In most mammalian brains, the subventricular zone (SVZ) is a germinative layer that maintains neurogenic activity throughout adulthood. Neuronal precursors arising from this region migrate through the rostral migratory stream (RMS) and reach the olfactory bulbs where they differentiate and integrate into the local circuitry. Recently, studies have shown that heat shock proteins have an important role in cancer cell migration and blocking Hsp90 function was shown to hinder cell migration in the developing cerebellum...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28439461/quantitative-assessment-of-fibroblast-growth-factor-receptor-1-expression-in-neurons-and-glia
#6
Lisha Choubey, Jantzen C Collette, Karen Müller Smith
BACKGROUND: Fibroblast growth factors (FGFs) and their receptors (FGFRs) have numerous functions in the developing and adult central nervous system (CNS). For example, the FGFR1 receptor is important for proliferation and fate specification of radial glial cells in the cortex and hippocampus, oligodendrocyte proliferation and regeneration, midline glia morphology and soma translocation, Bergmann glia morphology, and cerebellar morphogenesis. In addition, FGFR1 signaling in astrocytes is required for postnatal maturation of interneurons expressing parvalbumin (PV)...
2017: PeerJ
https://www.readbyqxmd.com/read/28424008/olfactory-development-part-2-neuroanatomic-maturation-and-dysgeneses
#7
REVIEW
Harvey B Sarnat, Laura Flores-Sarnat
Olfactory axons project from nasal epithelium to the primitive telencephalon before olfactory bulbs form. Olfactory bulb neurons do not differentiate in situ but arrive via the rostral migratory stream. Synaptic glomeruli and concentric laminar architecture are unlike other cortices. Fetal olfactory maturation of neuronal differentiation, synaptogenesis, and myelination remains incomplete at term and have a protracted course of postnatal development. The olfactory ventricular recess involutes postnatally but dilates in congenital hydrocephalus...
May 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28406573/brief-report-robo1-regulates-the-migration-of-human-subventricular-zone-neural-progenitor-cells-during-development
#8
Hugo Guerrero-Cazares, Emily Lavell, Linda Chen, Paula Schiapparelli, Montserrat Lara-Velazquez, Vivian Capilla-Gonzalez, Anna Christina Clements, Gabrielle Drummond, Liron Noiman, Katrina Thaler, Anne Burke, Alfredo Quiñones-Hinojosa
Human neural progenitor cell (NPC) migration within the subventricular zone (SVZ) of the lateral ganglionic eminence is an active process throughout early brain development. The migration of human NPCs from the SVZ to the olfactory bulb during fetal stages resembles what occurs in adult rodents. As the human brain develops during infancy, this migratory stream is drastically reduced in cell number and becomes barely evident in adults. The mechanisms regulating human NPC migration are unknown. The Slit-Robo signaling pathway has been defined as a chemorepulsive cue involved in axon guidance and neuroblast migration in rodents...
July 2017: Stem Cells
https://www.readbyqxmd.com/read/28279192/stroke-alters-behavior-of-human-skin-derived-neural-progenitors-after-transplantation-adjacent-to-neurogenic-area-in-rat-brain
#9
Carlos de la Rosa-Prieto, Cecilia Laterza, Ana Gonzalez-Ramos, Somsak Wattananit, Ruimin Ge, Olle Lindvall, Daniel Tornero, Zaal Kokaia
BACKGROUND: Intracerebral transplantation of human induced pluripotent stem cells (iPSCs) can ameliorate behavioral deficits in animal models of stroke. How the ischemic lesion affects the survival of the transplanted cells, their proliferation, migration, differentiation, and function is only partly understood. METHODS: Here we have assessed the influence of the stroke-induced injury on grafts of human skin iPSCs-derived long-term neuroepithelial-like stem cells using transplantation into the rostral migratory stream (RMS), adjacent to the neurogenic subventricular zone, in adult rats as a model system...
March 9, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28258169/epha4-regulates-neuroblast-and-astrocyte-organization-in-a-neurogenic-niche
#10
Krysti L Todd, Kasey L Baker, Matthew B Eastman, Frederick W Kolling, Alexandra G Trausch, Craig E Nelson, Joanne C Conover
Significant migration cues are required to guide and contain newly generated rodent subventricular zone (SVZ) neuroblasts as they transit along the lateral ventricles and then through the anterior forebrain to their ultimate site of differentiation in the olfactory bulbs (OBs). These cues enforce strict neuroblast spatial boundaries within the dense astroglial meshwork of the SVZ and rostral migratory stream (RMS), yet are permissive to large-scale neuroblast migration. Therefore, the molecular mechanisms that define these cues and control dynamic interactions between migratory neuroblasts and surrounding astrocytes are of particular interest...
March 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28251650/mechanisms-of-neuronal-migration-in-the-adult-brain
#11
REVIEW
Naoko Kaneko, Masato Sawada, Kazunobu Sawamoto
Adult neurogenesis was first observed nearly 60 years ago, and it has since grown into an important neurochemistry research field. Much recent research has focused on the treatment of brain diseases through neuronal regeneration with endogenously generated neurons. In the adult brain, immature neurons called neuroblasts are continuously generated in the ventricular-subventricular zone (V-SVZ). These neuroblasts migrate rapidly through the rostral migratory stream to the olfactory bulb, where they mature and are integrated into the neuronal circuitry...
June 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28247022/physical-exercise-rescues-defective-neural-stem-cells-and-neurogenesis-in-the-adult-subventricular-zone-of-btg1-knockout-mice
#12
Valentina Mastrorilli, Chiara Scopa, Daniele Saraulli, Marco Costanzi, Raffaella Scardigli, Jean-Pierre Rouault, Stefano Farioli-Vecchioli, Felice Tirone
Adult neurogenesis occurs throughout life in the dentate gyrus (DG) and the subventricular zone (SVZ), where glia-like stem cells generate new neurons. Voluntary running is a powerful neurogenic stimulus triggering the proliferation of progenitor cells in the DG but, apparently, not in the SVZ. The antiproliferative gene Btg1 maintains the quiescence of DG and SVZ stem cells. Its ablation causes intense proliferation of DG and SVZ stem/progenitor cells in young mice, followed, during adulthood, by progressive decrease of the proliferative capacity...
February 28, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28223923/embryonic-and-postnatal-expression-of-aryl-hydrocarbon-receptor-mrna-in-mouse-brain
#13
Eiki Kimura, Chiharu Tohyama
Aryl hydrocarbon receptor (AhR), a member of the basic helix-loop-helix-Per-Arnt-Sim transcription factor family, plays a critical role in the developing nervous system of invertebrates and vertebrates. Dioxin, a ubiquitous environmental pollutant, avidly binds to this receptor, and maternal exposure to dioxin has been shown to impair higher brain functions and dendritic morphogenesis, possibly via an AhR-dependent mechanism. However, there is little information on AhR expression in the developing mammalian brain...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28223495/secretagogin-dependent-matrix-metalloprotease-2-release-from-neurons-regulates-neuroblast-migration
#14
János Hanics, Edit Szodorai, Giuseppe Tortoriello, Katarzyna Malenczyk, Erik Keimpema, Gert Lubec, Zsófia Hevesi, Mirjam I Lutz, Márk Kozsurek, Zita Puskár, Zsuzsanna E Tóth, Ludwig Wagner, Gábor G Kovács, Tomas G M Hökfelt, Tibor Harkany, Alán Alpár
The rostral migratory stream (RMS) is viewed as a glia-enriched conduit of forward-migrating neuroblasts in which chemorepulsive signals control the pace of forward migration. Here we demonstrate the existence of a scaffold of neurons that receive synaptic inputs within the rat, mouse, and human fetal RMS equivalents. These neurons express secretagogin, a Ca(2+)-sensor protein, to execute an annexin V-dependent externalization of matrix metalloprotease-2 (MMP-2) for reconfiguring the extracellular matrix locally...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28115261/injection-of-sdf-1-loaded-nanoparticles-following-traumatic-brain-injury-stimulates-neural-stem-cell-recruitment
#15
Laura N Zamproni, Mayara V Mundim, Marimelia A Porcionatto, Anne des Rieux
Recruiting neural stem cell (NSC) at the lesion site is essential for central nervous system repair. This process could be triggered by the local delivery of the chemokine SDF-1. We compared two PLGA formulations for local brain SDF-1 delivery: SDF-1 loaded microspheres (MS) and SDF-1 loaded nanoparticles (NP). Both formulations were able to encapsulate more than 80% of SDF-1 but presented different release profiles, with 100% of SDF-1 released after 6days for the MS and with 25% of SDF-1 released after 2 weeks for NP...
March 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27908425/copper-accumulation-in-rodent-brain-astrocytes-a-species-difference
#16
Brendan Sullivan, Gregory Robison, Yulia Pushkar, John K Young, Kebreten F Manaye
Changes in Cu homeostasis have been implicated in multiple neurodegenerative diseases. Factors controlling and regulating the distribution of Cu in the brain remain largely unknown. We have previously reported that a sub-set of astrocytes in the subventricular zone (SVZ) contain Cu-rich aggregates. Here we expand previous studies with detailed X-ray fluorescent imaging (XRF) analysis of the additional brain areas of hippocampus (HP) and rostral migratory stream (RMS). We also use conventional DAB (3,3'-diaminobenzidine) staining which accesses both peroxidase and pseudo-peroxidase activities...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27771498/ephrinb3-restricts-endogenous-neural-stem-cell-migration-after-traumatic-brain-injury
#17
Kirsty J Dixon, Jose Mier, Shyam Gajavelli, Alisa Turbic, Ross Bullock, Ann M Turnley, Daniel J Liebl
Traumatic brain injury (TBI) leads to a series of pathological events that can have profound influences on motor, sensory and cognitive functions. Conversely, TBI can also stimulate neural stem/progenitor cell proliferation leading to increased numbers of neuroblasts migrating outside their restrictive neurogenic zone to areas of damage in support of tissue integrity. Unfortunately, the factors that regulate migration are poorly understood. Here, we examine whether ephrinB3 functions to restrict neuroblasts from migrating outside the subventricular zone (SVZ) and rostral migratory stream (RMS)...
November 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27601978/neuroblast-distribution-after-cortical-impact-is-influenced-by-white-matter-injury-in-the-immature-gyrencephalic-brain
#18
Sabrina R Taylor, Colin M Smith, Kristen L Keeley, Declan McGuone, Carter P Dodge, Ann-Christine Duhaime, Beth A Costine
Cortical contusions are a common type of traumatic brain injury (TBI) in children. Current knowledge of neuroblast response to cortical injury arises primarily from studies utilizing aspiration or cryoinjury in rodents. In infants and children, cortical impact affects both gray and white matter and any neurogenic response may be complicated by the large expanse of white matter between the subventricular zone (SVZ) and the cortex, and the large number of neuroblasts in transit along the major white matter tracts to populate brain regions...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27601444/glycogen-serves-as-an-energy-source-that-maintains-astrocyte-cell-proliferation-in-the-neonatal-telencephalon
#19
Hitoshi Gotoh, Tadashi Nomura, Katsuhiko Ono
Large amounts of energy are required when cells undergo cell proliferation and differentiation for mammalian neuronal development. Early neonatal mice face transient starvation and use stored energy for survival or to support development. Glycogen is a branched polysaccharide that is formed by glucose, and serves as an astrocytic energy store for rapid energy requirements. Although it is present in radial glial cells and astrocytes, the role of glycogen during development remains unclear. In the present study, we demonstrated that glycogen accumulated in glutamate aspartate transporter (GLAST)+ astrocytes in the subventricular zone and rostral migratory stream...
June 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27573347/decreased-demand-for-olfactory-periglomerular-cells-impacts-on-neural-precursor-cell-viability-in-the-rostral-migratory-stream
#20
Anika Langenfurth, Song Gu, Verena Bautze, Caiyi Zhang, Julia E Neumann, Ulrich Schüller, Kristin Stock, Susanne A Wolf, Anna-Maria Maier, Giorgia Mastrella, Andrew Pak, Hongwei Cheng, Roland E Kälin, Kenn Holmbeck, Jörg Strotmann, Helmut Kettenmann, Rainer Glass
The subventricular zone (SVZ) provides a constant supply of new neurons to the olfactory bulb (OB). Different studies have investigated the role of olfactory sensory input to neural precursor cell (NPC) turnover in the SVZ but it was not addressed if a reduced demand specifically for periglomerular neurons impacts on NPC-traits in the rostral migratory stream (RMS). We here report that membrane type-1 matrix metalloproteinase (MT1-MMP) deficient mice have reduced complexity of the nasal turbinates, decreased sensory innervation of the OB, reduced numbers of olfactory glomeruli and reduced OB-size without alterations in SVZ neurogenesis...
2016: Scientific Reports
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