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https://www.readbyqxmd.com/read/27908425/copper-accumulation-in-rodent-brain-astrocytes-a-species-difference
#1
Brendan Sullivan, Gregory Robison, Yulia Pushkar, John K Young, Kebreten F Manaye
Changes in Cu homeostasis have been implicated in multiple neurodegenerative diseases. Factors controlling and regulating the distribution of Cu in the brain remain largely unknown. We have previously reported that a sub-set of astrocytes in the subventricular zone (SVZ) contain Cu-rich aggregates. Here we expand previous studies with detailed X-ray fluorescent imaging (XRF) analysis of the additional brain areas of hippocampus (HP) and rostral migratory stream (RMS). We also use conventional DAB (3,3'-diaminobenzidine) staining which accesses both peroxidase and pseudo-peroxidase activities...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27771498/ephrinb3-restricts-endogenous-neural-stem-cell-migration-after-traumatic-brain-injury
#2
Kirsty J Dixon, Jose Mier, Shyam Gajavelli, Alisa Turbic, Ross Bullock, Ann M Turnley, Daniel J Liebl
Traumatic brain injury (TBI) leads to a series of pathological events that can have profound influences on motor, sensory and cognitive functions. Conversely, TBI can also stimulate neural stem/progenitor cell proliferation leading to increased numbers of neuroblasts migrating outside their restrictive neurogenic zone to areas of damage in support of tissue integrity. Unfortunately, the factors that regulate migration are poorly understood. Here, we examine whether ephrinB3 functions to restrict neuroblasts from migrating outside the subventricular zone (SVZ) and rostral migratory stream (RMS)...
September 28, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27601978/neuroblast-distribution-after-cortical-impact-is-influenced-by-white-matter-injury-in-the-immature-gyrencephalic-brain
#3
Sabrina R Taylor, Colin M Smith, Kristen L Keeley, Declan McGuone, Carter P Dodge, Ann-Christine Duhaime, Beth A Costine
Cortical contusions are a common type of traumatic brain injury (TBI) in children. Current knowledge of neuroblast response to cortical injury arises primarily from studies utilizing aspiration or cryoinjury in rodents. In infants and children, cortical impact affects both gray and white matter and any neurogenic response may be complicated by the large expanse of white matter between the subventricular zone (SVZ) and the cortex, and the large number of neuroblasts in transit along the major white matter tracts to populate brain regions...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27601444/glycogen-serves-as-an-energy-source-that-maintains-astrocyte-cell-proliferation-in-the-neonatal-telencephalon
#4
Hitoshi Gotoh, Tadashi Nomura, Katsuhiko Ono
Large amounts of energy are required when cells undergo cell proliferation and differentiation for mammalian neuronal development. Early neonatal mice face transient starvation and use stored energy for survival or to support development. Glycogen is a branched polysaccharide that is formed by glucose, and serves as an astrocytic energy store for rapid energy requirements. Although it is present in radial glial cells and astrocytes, the role of glycogen during development remains unclear. In the present study, we demonstrated that glycogen accumulated in glutamate aspartate transporter (GLAST)+ astrocytes in the subventricular zone and rostral migratory stream...
September 6, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27573347/decreased-demand-for-olfactory-periglomerular-cells-impacts-on-neural-precursor-cell-viability-in-the-rostral-migratory-stream
#5
Anika Langenfurth, Song Gu, Verena Bautze, Caiyi Zhang, Julia E Neumann, Ulrich Schüller, Kristin Stock, Susanne A Wolf, Anna-Maria Maier, Giorgia Mastrella, Andrew Pak, Hongwei Cheng, Roland E Kälin, Kenn Holmbeck, Jörg Strotmann, Helmut Kettenmann, Rainer Glass
The subventricular zone (SVZ) provides a constant supply of new neurons to the olfactory bulb (OB). Different studies have investigated the role of olfactory sensory input to neural precursor cell (NPC) turnover in the SVZ but it was not addressed if a reduced demand specifically for periglomerular neurons impacts on NPC-traits in the rostral migratory stream (RMS). We here report that membrane type-1 matrix metalloproteinase (MT1-MMP) deficient mice have reduced complexity of the nasal turbinates, decreased sensory innervation of the OB, reduced numbers of olfactory glomeruli and reduced OB-size without alterations in SVZ neurogenesis...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27555806/perinatal-exposure-to-glufosinate-ammonium-herbicide-impairs-neurogenesis-and-neuroblast-migration-through-cytoskeleton-destabilization
#6
Ameziane Herzine, Anthony Laugeray, Justyne Feat, Arnaud Menuet, Valérie Quesniaux, Olivier Richard, Jacques Pichon, Céline Montécot-Dubourg, Olivier Perche, Stéphane Mortaud
Neurogenesis, a process of generating functional neurons from neural precursors, occurs throughout life in restricted brain regions such as the subventricular zone (SVZ). During this process, newly generated neurons migrate along the rostral migratory stream to the olfactory bulb to replace granule cells and periglomerular neurons. This neuronal migration is pivotal not only for neuronal plasticity but also for adapted olfactory based behaviors. Perturbation of this highly controlled system by exogenous chemicals has been associated with neurodevelopmental disorders...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27532288/the-distribution-of-ki-67-and-doublecortin-immunopositive-cells-in-the-brains-of-three-microchiropteran-species-hipposideros-fuliginosus-triaenops-persicus-and-asellia-tridens
#7
Richard Chawana, Nina Patzke, Abdulaziz N Alagaili, Nigel C Bennett, Osama B Mohammed, Consolate Kaswera-Kyamakya, Emmanuel Gilissen, Amadi O Ihunwo, John D Pettigrew, Paul R Manger
The current study uses Ki-67 and doublecortin (DCX) immunohistochemistry to delineate potential neurogenic zones, migratory pathways and terminal fields associated with adult neurogenesis in the brains of three microchiropterans. As with most mammals studied to date, the canonical subgranular and subventricular neurogenic zones were observed. Distinct labelling of newly born cells and immature neurons within the dentate gyrus of the hippocampus was observed in all species. A distinct rostral migratory stream, that appears to split around the medial aspect of the caudate nucleus was observed...
August 17, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27423908/localization-of-%C3%AE-1-2-fucose-glycan-in-the-mouse-olfactory-pathway
#8
Daisuke Kondoh, Akihiro Kamikawa, Motoki Sasaki, Nobuo Kitamura
Glycoconjugates in the olfactory system play critical roles in neuronal formation, and α1-2 fucose (α1-2Fuc) glycan mediates neurite outgrowth and synaptic plasticity. Histochemical findings of α1-2Fuc glycan in the mouse olfactory system detected using Ulex europaeus agglutinin-I (UEA-I) vary. This study histochemically assessed the main olfactory and vomeronasal pathways in male and female ICR and C57BL/6J mice aged 3-4 months using UEA-I. Ulex europaeus agglutinin-I reacted with most receptor cells arranged mainly at the basal region of the olfactory epithelium...
July 16, 2016: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/27299504/cytoarchitecture-proliferative-activity-and-neuroblast-migration-in-the-subventricular-zone-and-lateral-ventricle-extension-of-the-adult-guinea-pig-brain
#9
Nery Jara, Manuel Cifuentes, Fernando Martínez, Katterine Salazar, Francisco Nualart
In the mouse brain, neuroblasts generated in the subventricular zone (SVZ) migrate to the olfactory bulb (OB) through the rostral migratory stream (RMS). Although the RMS is not present in the human brain, a migratory pathway that is organized around a ventricular cavity that reaches the OB has been reported. A similar cavity, the lateral ventricle extension (LVE), is found in the adult guinea pig brain. Therefore, we analyzed cytoarchitecture, proliferative activity and precursor cell migration in the SVZ and LVE of 1-, 6- and 12-month-old guinea pigs...
June 14, 2016: Stem Cells
https://www.readbyqxmd.com/read/27295980/in-vivo-neural-tissue-engineering-cylindrical-biocompatible-hydrogels-that-create-new-neural-tracts-in-the-adult-mammalian-brain
#10
Amanda R Clark, Arrin B Carter, Lydia E Hager, Elmer M Price
Individuals with neurodegenerative disorders or brain injury have few treatment options and it has been proposed that endogenous adult neural stem cells can be harnessed to repopulate dysfunctional nonneurogenic regions of the brain. We have accomplished this through the development of rationally designed hydrogel implants that recruit endogenous cells from the adult subventricular zone to create new relatively long tracts of neuroblasts. These implants are biocompatible and biodegradable cylindrical hydrogels consisting of fibrin and immobilized neurotrophic factors...
August 1, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27294116/proliferation-and-glia-directed-differentiation-of-neural-stem-cells-in-the-subventricular-zone-of-the-lateral-ventricle-and-the-migratory-pathway-to-the-lesions-after-cortical-devascularization-of-adult-rats
#11
Feng Wan, Hua-Jing Bai, Jun-Qi Liu, Mo Tian, Yong-Xue Wang, Xin Niu, Yin-Chu Si
We investigated the effects of cortical devascularization on the proliferation, differentiation, and migration of neural stem cells (NSCs) in the subventricular zone (SVZ) of the lateral ventricle of adult rats. 60 adult male Wistar rats were randomly divided into control group and devascularized group. At 15 and 30 days after cerebral cortices were devascularized, rats were euthanized and immunohistochemical analysis was performed. The number of PCNA-, Vimentin-, and GFAP-positive cells in the bilateral SVZ of the lateral wall and the superior wall of the lateral ventricles of 15- and 30-day devascularized groups increased significantly compared with the control group (P < 0...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27243144/excess-hb-egf-which-promotes-vegf-signaling-leads-to-hydrocephalus
#12
Joon W Shim, Johanna Sandlund, Mustafa Q Hameed, Bonnie Blazer-Yost, Feng C Zhou, Michael Klagsbrun, Joseph R Madsen
Heparin binding epidermal growth factor-like growth factor (HB-EGF) is an angiogenic factor mediating radial migration of the developing forebrain, while vascular endothelial growth factor (VEGF) is known to influence rostral migratory stream in rodents. Cell migratory defects have been identified in animal models of hydrocephalus; however, the relationship between HB-EGF and hydrocephalus is unclear. We show that mice overexpressing human HB-EGF with β-galactosidase reporter exhibit an elevated VEGF, localization of β-galactosidase outside the subventricular zone (SVZ), subarachnoid hemorrhage, and ventriculomegaly...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27242400/adult-olfactory-bulb-interneuron-phenotypes-identified-by-targeting-embryonic-and-postnatal-neural-progenitors
#13
Maria Figueres-Oñate, Laura López-Mascaraque
Neurons are generated during embryonic development and in adulthood, although adult neurogenesis is restricted to two main brain regions, the hippocampus and olfactory bulb. The subventricular zone (SVZ) of the lateral ventricles generates neural stem/progenitor cells that continually provide the olfactory bulb (OB) with new granule or periglomerular neurons, cells that arrive from the SVZ via the rostral migratory stream. The continued neurogenesis and the adequate integration of these newly generated interneurons is essential to maintain homeostasis in the olfactory bulb, where the differentiation of these cells into specific neural cell types is strongly influenced by temporal cues...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27226325/pbx1-is-required-for-adult-subventricular-zone-neurogenesis
#14
Britta Moyo Grebbin, Ann-Christin Hau, Anja Groß, Marie Anders-Maurer, Jasmine Schramm, Matthew Koss, Christoph Wille, Michel Mittelbronn, Licia Selleri, Dorothea Schulte
TALE-homeodomain proteins function as components of heteromeric complexes that contain one member each of the PBC and MEIS/PREP subclasses. We recently showed that MEIS2 cooperates with the neurogenic transcription factor PAX6 in the control of adult subventricular zone (SVZ) neurogenesis in rodents. Expression of the PBC protein PBX1 in the SVZ has been reported, but its functional role(s) has not been investigated. Using a genetic loss-of-function mouse model, we now show that Pbx1 is an early regulator of SVZ neurogenesis...
July 1, 2016: Development
https://www.readbyqxmd.com/read/27197834/ahr-signaling-activation-disrupts-migration-and-dendritic-growth-of-olfactory-interneurons-in-the-developing-mouse
#15
Eiki Kimura, Yunjie Ding, Chiharu Tohyama
Perinatal exposure to a low level of dioxin, a ubiquitous environmental pollutant, has been shown to induce abnormalities in learning and memory, emotion, and sociality in laboratory animals later in adulthood. However, how aryl hydrocarbon receptor (AhR) signaling activation disrupts the higher brain function remains unclear. Therefore, we studied the possible effects of excessive activation of AhR signaling on neurodevelopmental processes, such as cellular migration and neurite growth, in mice. To this end, we transfected a constitutively active-AhR plasmid into stem cells in the lateral ventricle by in vivo electroporation on postnatal day 1...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27092050/the-role-of-astrocytes-in-the-generation-migration-and-integration-of-new-neurons-in-the-adult-olfactory-bulb
#16
REVIEW
Archana Gengatharan, Rodrigo R Bammann, Armen Saghatelyan
In mammals, new neurons in the adult olfactory bulb originate from a pool of neural stem cells in the subventricular zone of the lateral ventricles. Adult-born cells play an important role in odor information processing by adjusting the neuronal network to changing environmental conditions. Olfactory bulb neurogenesis is supported by several non-neuronal cells. In this review, we focus on the role of astroglial cells in the generation, migration, integration, and survival of new neurons in the adult forebrain...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27090594/transplantable-living-scaffolds-comprised-of-micro-tissue-engineered-aligned-astrocyte-networks-to-facilitate-central-nervous-system-regeneration
#17
Carla C Winter, Kritika S Katiyar, Nicole S Hernandez, Yeri J Song, Laura A Struzyna, James P Harris, D Kacy Cullen
UNLABELLED: Neurotrauma, stroke, and neurodegenerative disease may result in widespread loss of neural cells as well as the complex interconnectivity necessary for proper central nervous system function, generally resulting in permanent functional deficits. Potential regenerative strategies involve the recruitment of endogenous neural stem cells and/or directed axonal regeneration through the use of tissue engineered "living scaffolds" built to mimic features of three-dimensional (3-D) in vivo migratory or guidance pathways...
July 1, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27034423/molecular-control-of-two-novel-migratory-paths-for-cge-derived-interneurons-in-the-developing-mouse-brain
#18
Audrey Touzot, Nuria Ruiz-Reig, Tania Vitalis, Michèle Studer
GABAergic interneurons are highly heterogeneous and originate in the subpallium mainly from the medial (MGE) and caudal (CGE) ganglionic eminences according to a precise temporal sequence. MGE-derived cells disperse dorsally and migrate towards all regions of the cortex, but little is known about how CGE-derived cells reach their targets during development. Here, we unravel the existence of two novel CGE caudo-rostral migratory streams, one located laterally (LMS) and the other one more medially (MMS), that, together with the well-known caudal migratory stream (CMS), contribute to populate the neocortex, hippocampus and amygdala...
May 15, 2016: Development
https://www.readbyqxmd.com/read/27001681/clonal-mapping-of-astrocytes-in-the-olfactory-bulb-and-rostral-migratory-stream
#19
Jorge García-Marqués, Laura López-Mascaraque
Astrocytes are the most abundant glial population in the central nervous system, where they fulfill multiple essential tasks. Such diverse functions require a heterogeneous population of cells, yet it is still unclear how this cellular heterogeneity emerges during development. To clarify to what extent such diversity is determined by lineage, we have elaborated the first clonal map of astrocytes in the olfactory bulb and rostral migratory stream. Astrocyte clones are comprised of a limited number of cells, which arise from local progenitors and that are arranged following a radial pattern...
March 21, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/26964100/experimental-cerebral-malaria-spreads-along-the-rostral-migratory-stream
#20
Angelika Hoffmann, Johannes Pfeil, Julieta Alfonso, Felix T Kurz, Felix Sahm, Sabine Heiland, Hannah Monyer, Martin Bendszus, Ann-Kristin Mueller, Xavier Helluy, Mirko Pham
It is poorly understood how progressive brain swelling in experimental cerebral malaria (ECM) evolves in space and over time, and whether mechanisms of inflammation or microvascular sequestration/obstruction dominate the underlying pathophysiology. We therefore monitored in the Plasmodium berghei ANKA-C57BL/6 murine ECM model, disease manifestation and progression clinically, assessed by the Rapid-Murine-Coma-and-Behavioral-Scale (RMCBS), and by high-resolution in vivo MRI, including sensitive assessment of early blood-brain-barrier-disruption (BBBD), brain edema and microvascular pathology...
March 2016: PLoS Pathogens
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