keyword
MENU ▼
Read by QxMD icon Read
search

hans-dieter volk

keyword
https://www.readbyqxmd.com/read/29599716/atrophy-in-the-thalamus-but-not-cerebellum-is-specific-for-c9orf72-ftd-and-als-patients-an-atlas-based-volumetric-mri-study
#1
Sonja Schönecker, Christiane Neuhofer, Markus Otto, Albert Ludolph, Jan Kassubek, Bernhard Landwehrmeyer, Sarah Anderl-Straub, Elisa Semler, Janine Diehl-Schmid, Catharina Prix, Christian Vollmar, Juan Fortea, Hans-Jürgen Huppertz, Thomas Arzberger, Dieter Edbauer, Berend Feddersen, Marianne Dieterich, Matthias L Schroeter, Alexander E Volk, Klaus Fließbach, Anja Schneider, Johannes Kornhuber, Manuel Maler, Johannes Prudlo, Holger Jahn, Tobias Boeckh-Behrens, Adrian Danek, Thomas Klopstock, Johannes Levin
Background: The neuropathology of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS) due to a C9orf72 mutation is characterized by two distinct types of characteristic protein depositions containing either TDP-43 or so-called dipeptide repeat proteins that extend beyond frontal and temporal regions. Thalamus and cerebellum seem to be preferentially affected by the dipeptide repeat pathology unique to C9orf72 mutation carriers. Objective: This study aimed to determine if mutation carriers showed an enhanced degree of thalamic and cerebellar atrophy compared to sporadic patients or healthy controls...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29543914/immunoadsorption-to-remove-%C3%A3-2-adrenergic-receptor-antibodies-in-chronic-fatigue-syndrome-cfs-me
#2
Carmen Scheibenbogen, Madlen Loebel, Helma Freitag, Anne Krueger, Sandra Bauer, Michaela Antelmann, Wolfram Doehner, Nadja Scherbakov, Harald Heidecke, Petra Reinke, Hans-Dieter Volk, Patricia Grabowski
INTRODUCTION: Infection-triggered disease onset, chronic immune activation and autonomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) point to an autoimmune disease directed against neurotransmitter receptors. We had observed elevated autoantibodies against ß2 adrenergic receptors, and muscarinic 3 and 4 acetylcholine receptors in a subset of patients. Immunoadsorption (IA) was shown to be effective in removing autoantibodies and improve outcome in various autoimmune diseases...
2018: PloS One
https://www.readbyqxmd.com/read/29355676/a-comparative-analysis-of-human-bone-marrow-resident-and-peripheral-memory-b-cells
#3
Sonya C Becker, Martin Szyska, Angela Mensen, Katharina Hellwig, Raik Otto, Lisa Olfe, Hans-Dieter Volk, Thomas Dörner, Bernd Dörken, Carmen Scheibenbogen, Jörg Schröder, Andreas C Hocke, Il-Kang Na
No abstract text is available yet for this article.
January 31, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29113291/treatment-of-advanced-gastrointestinal-cancer-with-genetically-modified-autologous-mesenchymal-stem-cells-treat-me-1-a-phase-i-first-in-human-first-in-class-trial
#4
Jobst C von Einem, Sylvia Peter, Christine Günther, Hans-Dieter Volk, Gerald Grütz, Christoph Salat, Oliver Stoetzer, Peter J Nelson, Marlies Michl, Dominik P Modest, Julian W Holch, Martin Angele, Christiane Bruns, Hanno Niess, Volker Heinemann
Purpose: This phase I, first in human, first in class clinical study aimed at evaluating the safety, tolerability and efficacy of treatment with genetically modified mesenchymal stromal cells (MSC) in combination with ganciclovir (GCV). MSC_apceth_101 are genetically modified autologous MSCs used as vehicles for a cell-based gene therapy in patients with advanced gastrointestinal adenocarcinoma. Experimental design: The study design consisted of a dose-escalation 3 + 3 design...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29023707/guidelines-for-the-use-of-flow-cytometry-and-cell-sorting-in-immunological-studies
#5
Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Mübeccel Akdis, Immanuel Andrä, Francesco Annunziato, Petra Bacher, Vincenzo Barnaba, Luca Battistini, Wolfgang M Bauer, Sabine Baumgart, Burkhard Becher, Wolfgang Beisker, Claudia Berek, Alfonso Blanco, Giovanna Borsellino, Philip E Boulais, Ryan R Brinkman, Martin Büscher, Dirk H Busch, Timothy P Bushnell, Xuetao Cao, Andrea Cavani, Pratip K Chattopadhyay, Qingyu Cheng, Sue Chow, Mario Clerici, Anne Cooke, Antonio Cosma, Lorenzo Cosmi, Ana Cumano, Van Duc Dang, Derek Davies, Sara De Biasi, Genny Del Zotto, Silvia Della Bella, Paolo Dellabona, Günnur Deniz, Mark Dessing, Andreas Diefenbach, James Di Santo, Francesco Dieli, Andreas Dolf, Vera S Donnenberg, Thomas Dörner, Götz R A Ehrhardt, Elmar Endl, Pablo Engel, Britta Engelhardt, Charlotte Esser, Bart Everts, Anita Dreher, Christine S Falk, Todd A Fehniger, Andrew Filby, Simon Fillatreau, Marie Follo, Irmgard Förster, John Foster, Gemma A Foulds, Paul S Frenette, David Galbraith, Natalio Garbi, Maria Dolores García-Godoy, Jens Geginat, Kamran Ghoreschi, Lara Gibellini, Christoph Goettlinger, Carl S Goodyear, Andrea Gori, Jane Grogan, Mor Gross, Andreas Grützkau, Daryl Grummitt, Jonas Hahn, Quirin Hammer, Anja E Hauser, David L Haviland, David Hedley, Guadalupe Herrera, Martin Herrmann, Falk Hiepe, Tristan Holland, Pleun Hombrink, Jessica P Houston, Bimba F Hoyer, Bo Huang, Christopher A Hunter, Anna Iannone, Hans-Martin Jäck, Beatriz Jávega, Stipan Jonjic, Kerstin Juelke, Steffen Jung, Toralf Kaiser, Tomas Kalina, Baerbel Keller, Srijit Khan, Deborah Kienhöfer, Thomas Kroneis, Désirée Kunkel, Christian Kurts, Pia Kvistborg, Joanne Lannigan, Olivier Lantz, Anis Larbi, Salome LeibundGut-Landmann, Michael D Leipold, Megan K Levings, Virginia Litwin, Yanling Liu, Michael Lohoff, Giovanna Lombardi, Lilly Lopez, Amy Lovett-Racke, Erik Lubberts, Burkhard Ludewig, Enrico Lugli, Holden T Maecker, Glòria Martrus, Giuseppe Matarese, Christian Maueröder, Mairi McGrath, Iain McInnes, Henrik E Mei, Fritz Melchers, Susanne Melzer, Dirk Mielenz, Kingston Mills, David Mirrer, Jenny Mjösberg, Jonni Moore, Barry Moran, Alessandro Moretta, Lorenzo Moretta, Tim R Mosmann, Susann Müller, Werner Müller, Christian Münz, Gabriele Multhoff, Luis Enrique Munoz, Kenneth M Murphy, Toshinori Nakayama, Milena Nasi, Christine Neudörfl, John Nolan, Sussan Nourshargh, José-Enrique O'Connor, Wenjun Ouyang, Annette Oxenius, Raghav Palankar, Isabel Panse, Pärt Peterson, Christian Peth, Jordi Petriz, Daisy Philips, Winfried Pickl, Silvia Piconese, Marcello Pinti, A Graham Pockley, Malgorzata Justyna Podolska, Carlo Pucillo, Sally A Quataert, Timothy R D J Radstake, Bartek Rajwa, Jonathan A Rebhahn, Diether Recktenwald, Ester B M Remmerswaal, Katy Rezvani, Laura G Rico, J Paul Robinson, Chiara Romagnani, Anna Rubartelli, Beate Ruckert, Jürgen Ruland, Shimon Sakaguchi, Francisco Sala-de-Oyanguren, Yvonne Samstag, Sharon Sanderson, Birgit Sawitzki, Alexander Scheffold, Matthias Schiemann, Frank Schildberg, Esther Schimisky, Stephan A Schmid, Steffen Schmitt, Kilian Schober, Thomas Schüler, Axel Ronald Schulz, Ton Schumacher, Cristiano Scotta, T Vincent Shankey, Anat Shemer, Anna-Katharina Simon, Josef Spidlen, Alan M Stall, Regina Stark, Christina Stehle, Merle Stein, Tobit Steinmetz, Hannes Stockinger, Yousuke Takahama, Attila Tarnok, ZhiGang Tian, Gergely Toldi, Julia Tornack, Elisabetta Traggiai, Joe Trotter, Henning Ulrich, Marlous van der Braber, René A W van Lier, Marc Veldhoen, Salvador Vento-Asturias, Paulo Vieira, David Voehringer, Hans-Dieter Volk, Konrad von Volkmann, Ari Waisman, Rachael Walker, Michael D Ward, Klaus Warnatz, Sarah Warth, James V Watson, Carsten Watzl, Leonie Wegener, Annika Wiedemann, Jürgen Wienands, Gerald Willimsky, James Wing, Peter Wurst, Liping Yu, Alice Yue, Qianjun Zhang, Yi Zhao, Susanne Ziegler, Jakob Zimmermann
No abstract text is available yet for this article.
October 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28983790/influenza-vaccination-in-patients-with-common-variable-immunodeficiency-cvid
#6
REVIEW
Jan F Mieves, Kirsten Wittke, Helma Freitag, Hans-Dieter Volk, Carmen Scheibenbogen, Leif G Hanitsch
PURPOSE OF REVIEW: Vaccination against influenza in patients with primary antibody deficiency is recommended. Common variable immunodeficiency (CVID) is the most frequent and clinically relevant antibody deficiency disease and is by definition characterized by an impaired vaccination response. The purpose of this review is to present the current knowledge of humoral and cellular vaccine response to influenza in CVID patients. RECENT FINDINGS: Studies conducted in CVID patients demonstrated an impaired humoral response upon influenza vaccination...
October 5, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28961998/human-parvovirus-b19-b19v-up-regulates-cxcr4-surface-expression-of-circulating-angiogenic-cells-implications-for-cardiac-ischemia-in-b19v-cardiomyopathy
#7
Caroline Schmidt-Lucke, Thomas Zobel, Felicitas Escher, Carsten Tschöpe, Dirk Lassner, Uwe Kühl, Knut Gubbe, Hans-Dieter Volk, Heinz-Peter Schultheiss
Background: Human parvovirus B19 (B19V) infection and damage of circulating angiogenic cells (CAC) results in dysfunctional endogenous vascular repair (DEVR) with secondary end-organ damage. Trafficking of CAC is regulated by SDF-1α and the respective receptor CXCR4. We thus tested the hypothesis of a deregulated CXCR4/SDF-1α axis in symptomatic B19V-cardiomyopathy. Methods: CAC were infected in vitro with B19V and transfected with B19V-components. Read-out were: CXCR4-expression and migratory capacity at increasing doses of SDF-1α...
January 17, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28604802/serological-profiling-of-the-ebv-immune-response-in-chronic-fatigue-syndrome-using-a-peptide-microarray
#8
Madlen Loebel, Maren Eckey, Franziska Sotzny, Elisabeth Hahn, Sandra Bauer, Patricia Grabowski, Johannes Zerweck, Pavlo Holenya, Leif G Hanitsch, Kirsten Wittke, Peter Borchmann, Jens-Ulrich Rüffer, Falk Hiepe, Klemens Ruprecht, Uta Behrends, Carola Meindl, Hans-Dieter Volk, Ulf Reimer, Carmen Scheibenbogen
BACKGROUND: Epstein-Barr-Virus (EBV) plays an important role as trigger or cofactor for various autoimmune diseases. In a subset of patients with Chronic Fatigue Syndrome (CFS) disease starts with infectious mononucleosis as late primary EBV-infection, whereby altered levels of EBV-specific antibodies can be observed in another subset of patients. METHODS: We performed a comprehensive mapping of the IgG response against EBV comparing 50 healthy controls with 92 CFS patients using a microarray platform...
2017: PloS One
https://www.readbyqxmd.com/read/28596766/t-lymphocytes-influence-the-mineralization-process-of-bone
#9
Thaqif El Khassawna, Alessandro Serra, Christian H Bucher, Ansgar Petersen, Claudia Schlundt, Ireen Könnecke, Deeksha Malhan, Sebastian Wendler, Hanna Schell, Hans-Dieter Volk, Katharina Schmidt-Bleek, Georg N Duda
Bone is a unique organ able to regenerate itself after injuries. This regeneration requires the local interplay between different biological systems such as inflammation and matrix formation. Structural reconstitution is initiated by an inflammatory response orchestrated by the host immune system. However, the individual role of T cells and B cells in regeneration and their relationship to bone tissue reconstitution remain unknown. Comparing bone and fracture healing in animals with and without mature T and B cells revealed the essential role of these immune cells in determining the tissue mineralization and thus the bone quality...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28550199/comprehensive-approach-for-identifying-the-t-cell-subset-origin-of-cd3-and-cd28-antibody-activated-chimeric-antigen-receptor-modified-t-cells
#10
Michael Schmueck-Henneresse, Bilal Omer, Thomas Shum, Haruko Tashiro, Maksim Mamonkin, Natalia Lapteva, Sandhya Sharma, Lisa Rollins, Gianpietro Dotti, Petra Reinke, Hans-Dieter Volk, Cliona M Rooney
The outcome of therapy with chimeric Ag receptor (CAR)-modified T cells is strongly influenced by the subset origin of the infused T cells. However, because polyclonally activated T cells acquire a largely CD45RO+ CCR7- effector memory phenotype after expansion, regardless of subset origin, it is impossible to know which subsets contribute to the final T cell product. To determine the contribution of naive T cell, memory stem T cell, central memory T cell, effector memory T cell, and terminally differentiated effector T cell populations to the CD3 and CD28-activated CAR-modified T cells that we use for therapy, we followed the fate and function of individually sorted CAR-modified T cell subsets after activation with CD3 and CD28 Abs (CD3/28), transduction and culture alone, or after reconstitution into the relevant subset-depleted population...
July 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28100035/stromal-cells-act-as-guardians-for-endothelial-progenitors-by-reducing-their-immunogenicity-after-co-transplantation
#11
Naima Souidi, Meaghan Stolk, Juliane Rudeck, Dirk Strunk, Katharina Schallmoser, Hans-Dieter Volk, Martina Seifert
Regeneration of injured tissues requires effective therapeutic strategies supporting vasculogenesis. The lack of instantly available autologous cell sources and immunogenicity of allogeneic endothelial (progenitor) cells limits clinical progress. Based on the immunosuppressive potency of mesenchymal stem/progenitor cells (MSCs), we investigated whether crosstalk between endothelial colony-forming progenitor cells (ECFCs) and MSCs during vasculogenesis could lower allogeneic T cell responses against ECFCs allowing long-term engraftment in vivo...
May 2017: Stem Cells
https://www.readbyqxmd.com/read/27976803/cd31-cells-from-peripheral-blood-facilitate-bone-regeneration-in-biologically-impaired-conditions-through-combined-effects-on-immunomodulation-and-angiogenesis
#12
F Andrea Sass, Katharina Schmidt-Bleek, Agnes Ellinghaus, Sebastian Filter, Alexander Rose, Bernd Preininger, Simon Reinke, Sven Geissler, Hans-Dieter Volk, Georg N Duda, Anke Dienelt
Controlled revascularization and inflammation are key elements regulating endogenous regeneration after (bone) tissue trauma. Peripheral blood-derived cell subsets, such as regulatory T-helper cells and circulating (endothelial) progenitor cells, respectively, can support endogenous tissue healing, whereas effector T cells that are associated with an aged immune system can hinder bone regeneration. CD31 is expressed by diverse leukocytes and is well recognized as a marker of circulating endothelial (precursor) cells; however, CD31 is absent from the surface of differentiated effector T cells...
May 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27843200/mmp8-is-increased-in-lesions-and-blood-of-acne-inversa-patients-a-potential-link-to-skin-destruction-and-metabolic-alterations
#13
Athanasia Tsaousi, Ellen Witte, Katrin Witte, Hans-Joachim Röwert-Huber, Hans-Dieter Volk, Wolfram Sterry, Kerstin Wolk, Sylke Schneider-Burrus, Robert Sabat
Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated with metabolic alterations. Here, we demonstrate that one of the most highly upregulated molecules in AI lesions is matrix metalloproteinase 8 (MMP8), an enzyme specialized in the degradation of extracellular matrix components and the HDL component apolipoprotein A-I...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27709611/clinical-development-of-cell-therapies-setting-the-stage-for-academic-success
#14
M Abou-El-Enein, H-D Volk, P Reinke
Cellular therapies have potential to treat a wide range of diseases with autologous immunotherapies showing unprecedented therapeutic promise in clinical trials. Such therapies are mainly developed by academic researchers applying small-scale production, targeting rare and unmet medical needs. Here, we highlight the clinical translation of immunotherapy product in an academic setting, which may serve as a success model for early academic development of cell-based therapeutics.
January 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27403624/wild-immunology-assessed-by-multidimensional-mass-cytometry
#15
Alberto Sada Japp, Kerstin Hoffmann, Stephan Schlickeiser, Rainer Glauben, Christos Nikolaou, Holden T Maecker, Julian Braun, Nadine Matzmohr, Birgit Sawitzki, Britta Siegmund, Andreas Radbruch, Hans-Dieter Volk, Marco Frentsch, Desiree Kunkel, Andreas Thiel
A great part of our knowledge on mammalian immunology has been established in laboratory settings. The use of inbred mouse strains enabled controlled studies of immune cell and molecule functions in defined settings. These studies were usually performed in specific-pathogen free (SPF) environments providing standardized conditions. In contrast, mammalians including humans living in their natural habitat are continuously facing pathogen encounters throughout their life. The influences of environmental conditions on the signatures of the immune system and on experimental outcomes are yet not well defined...
January 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/27288308/putting-a-price-tag-on-novel-autologous-cellular-therapies
#16
Mohamed Abou-El-Enein, Gerhard Bauer, Nicholas Medcalf, Hans-Dieter Volk, Petra Reinke
Cell therapies, especially autologous therapies, pose significant challenges to researchers who wish to move from small, probably academic, methods of manufacture to full commercial scale. There is a dearth of reliable information about the costs of operation, and this makes it difficult to predict with confidence the investment needed to translate the innovations to the clinic, other than as small-scale, clinician-led prescriptions. Here, we provide an example of the results of a cost model that takes into account the fixed and variable costs of manufacture of one such therapy...
August 2016: Cytotherapy
https://www.readbyqxmd.com/read/27055021/cellular-and-humoral-influenza-specific-immune-response-upon-vaccination-in-patients-with-common-variable-immunodeficiency-and-unclassified-antibody-deficiency
#17
Leif G Hanitsch, Madlen Löbel, Jan Florian Mieves, Sandra Bauer, Nina Babel, Brunhilde Schweiger, Kirsten Wittke, Patricia Grabowski, Hans-Dieter Volk, Carmen Scheibenbogen
BACKGROUND: Immunization against seasonal influenza with inactivated vaccine is recommended for patients with common variable immunodeficiency (CVID). However, humoral vaccine response in CVID patients is frequently impaired and current knowledge on T cell vaccine response in CVID and other patients with antibody deficiency is poor. OBJECTIVE: In the present study, we comparatively analyzed the antibody and T cellular immune response of patients with CVID and unclassified antibody deficiency to influenza vaccination in the season 2013-2014...
May 5, 2016: Vaccine
https://www.readbyqxmd.com/read/26824266/tgf%C3%AE-dependent-expression-of-pd-1-and-pd-l1-controls-cd8-t-cell-anergy-in-transplant-tolerance
#18
Marije Baas, Alix Besançon, Tania Goncalves, Fabrice Valette, Hideo Yagita, Birgit Sawitzki, Hans-Dieter Volk, Emmanuelle Waeckel-Enée, Benedita Rocha, Lucienne Chatenoud, Sylvaine You
CD8(+) T cell anergy is a critical mechanism of peripheral tolerance, poorly investigated in response to immunotherapy. Here, using a pancreatic islet allograft model and CD3 antibody therapy, we showed, by single cell gene profiling, that intragraft CD8(+) lymphocytes coexpressing granzyme B and perforin were selectively depleted through the Fas/FasL pathway. This step led to long-standing anergy of the remaining CD8(+) T cells marked by the absence of cytotoxic/inflammatory gene expression also confirmed by transcriptome analysis...
January 29, 2016: ELife
https://www.readbyqxmd.com/read/26612594/interleukin-29-induces-epithelial-production-of-cxcr3a-ligands-and-t-cell-infiltration
#19
Ellen Witte, Georgios Kokolakis, Katrin Witte, Katarzyna Warszawska, Markus Friedrich, Demetrios Christou, Stefan Kirsch, Wolfram Sterry, Hans-Dieter Volk, Robert Sabat, Kerstin Wolk
UNLABELLED: Psoriasis is considered as a model for chronic immune-mediated disorders. Th17-cells are pivotal players in those diseases. Recently, we demonstrated that Th17-cells produce interleukin (IL)-29 and that IL-29 is highly present in psoriatic lesions. Whether IL-29, with its action on epithelial cells and melanocytes, contributes to psoriasis pathogenesis, was unknown so far. Analysis of IL-29-treated human keratinocytes revealed induction of the chemokines CXCL10, CXCL11, and, to a much lesser extent, CXCL9...
April 2016: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/26451017/cholinergic-pathway-suppresses-pulmonary-innate-immunity-facilitating-pneumonia-after-stroke
#20
Odilo Engel, Levent Akyüz, Andrey C da Costa Goncalves, Katarzyna Winek, Claudia Dames, Mareike Thielke, Susanne Herold, Chotima Böttcher, Josef Priller, Hans Dieter Volk, Ulrich Dirnagl, Christian Meisel, Andreas Meisel
BACKGROUND AND PURPOSE: Temporary immunosuppression has been identified as a major risk factor for the development of pneumonia after acute central nervous system injury. Although overactivation of the sympathetic nervous system was previously shown to mediate suppression of systemic cellular immune responses after stroke, the role of the parasympathetic cholinergic anti-inflammatory pathway in the antibacterial defense in lung remains largely elusive. METHODS: The middle cerebral artery occlusion model in mice was used to examine the influence of the parasympathetic nervous system on poststroke immunosuppression...
November 2015: Stroke; a Journal of Cerebral Circulation
keyword
keyword
107606
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"