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https://www.readbyqxmd.com/read/29471391/comparative-efficacy-of-enrofloxacin-to-that-of-tulathromycin-for-the-control-of-bovine-respiratory-disease-and-prevalence-of-antimicrobial-resistance-in-mannheimia-haemolytica-in-calves-at-high-risk-of-developing-bovine-respiratory-disease
#1
S Crosby, B Credille, S Giguère, R Berghaus
Bovine respiratory disease (BRD) is the most common cause of morbidity and mortality in North American beef cattle. Mannheimia haemolytica (Mh) is the bacterial pathogen most often isolated from cattle with BRD and the prevalence of antimicrobial resistance (AMR) in this organism has increased in recent years. Antimicrobials are commonly used to prevent BRD in cattle at high-risk of developing BRD, however, recent work would suggest that this practice might be one factor contributing to the increased prevalence of AMR in Mh...
February 19, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29471005/mir-155-5p-controls-colon-cancer-cell-migration-via-post-transcriptional-regulation-of-human-antigen-r-hur
#2
Amr Al-Haidari, Anwar Algaber, Raed Madhi, Ingvar Syk, Henrik Thorlacius
Colorectal cancer (CRC) is the third most common cancer and a significant cause of cancer-related deaths worldwide. Metastasis is the worst prognostic factor for patients with CRC. HuR (ELAVL1) is overexpressed in CRC and has been reported to promote colon cancer growth by targeting RNA in the cell cytoplasm. Herein, the role of miR-155-5p in regulating HuR expression and cell migration was examined in colon cancer cells. MiR-155-5p knockdown in serum-starved colon cancer cells decreased both colon cancer cell chemotaxis and cytoplasmic expression of HuR...
February 19, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29470350/analysis-of-luminex-based-algorithms-to-define-unacceptable-hla-antibodies-in-cdc-crossmatch-negative-kidney-transplant-recipients
#3
Daniel Zecher, Christian Bach, Adrian Preiss, Christoph Staudner, Kirsten Utpatel, Matthias Evert, Bettina Jung, Tobias Bergler, Carsten A Böger, Bernd M Spriewald, Bernhard Banas
BACKGROUND: HLA-specific antibodies detected by solid phase assays are increasingly used to define unacceptable HLA antigen mismatches (UAM) prior to renal transplantation. The accuracy of this approach is unclear. METHODS: Day of transplant sera from 211 CDC-crossmatch-negative patients were retrospectively analyzed for donor-specific anti-HLA antibodies (DSA) using Luminex technology. HLA were defined as UAM if DSA had mean fluorescence intensity above (I) 3000 (patients retransplanted and those with DSA against HLA class I and II) or 5000 (all other patients), (II) 5000 for HLA A, B and DR and 10,000 for HLA DQ or (III) 10,000 (all HLA)...
February 20, 2018: Transplantation
https://www.readbyqxmd.com/read/29470345/summary-of-2017-fda-public-workshop-antibody-mediated-rejection-in-kidney-transplantation
#4
Ergun Velidedeoglu, Marc W Cavaillé-Coll, Shukal Bala, Ozlem A Belen, Yan Wang, Renata Albrecht
BACKGROUND: Despite major advances in understanding the pathophysiology of antibody mediated rejection (AMR); prevention, diagnosis and treatment remain unmet medical needs. It appears that early T-cell mediated rejection (TCMR), de novo donor specific antibody (dnDSA) formation and AMR result from patient or physician initiated suboptimal immunosuppression, and represent landmarks in an ongoing process rather than separate events. METHODS: On April 12-13, 2017, the Food and Drug Administration (FDA) sponsored a public workshop on AMR in kidney transplantation to discuss new advances, importance of immunosuppressive medication nonadherence in dnDSA formation, associations between AMR, cellular rejection, changes in GFR, and challenges of clinical trial design for the prevention and treatment of AMR...
February 20, 2018: Transplantation
https://www.readbyqxmd.com/read/29468055/comparison-of-governance-approaches-for-the-control-of-antimicrobial-resistance-analysis-of-three-european-countries
#5
REVIEW
Gabriel Birgand, Enrique Castro-Sánchez, Sonja Hansen, Petra Gastmeier, Jean-Christophe Lucet, Ewan Ferlie, Alison Holmes, Raheelah Ahmad
Policy makers and governments are calling for coordination to address the crisis emerging from the ineffectiveness of current antibiotics and stagnated pipe-line of new ones - antimicrobial resistance (AMR). Wider contextual drivers and mechanisms are contributing to shifts in governance strategies in health care, but are national health system approaches aligned with strategies required to tackle antimicrobial resistance? This article provides an analysis of governance approaches within healthcare systems including: priority setting, performance monitoring and accountability for AMR prevention in three European countries: England, France and Germany...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29466981/a-novel-purified-lactobacillus-acidophilus-20079-exopolysaccharide-la-eps-20079-molecularly-regulates-both-apoptotic-and-nf-%C3%AE%C2%BAb-inflammatory-pathways-in-human-colon-cancer
#6
Nehal M El-Deeb, Abdelrahman M Yassin, Lamiaa A Al-Madboly, Amr El-Hawiet
BACKGROUND: The direct link between inflammatory bowel diseases and colorectal cancer is well documented. Previous studies have reported that some lactic acid bacterial strains could inhibit colon cancer progression however; the exact molecules involved have not yet been identified. So, in the current study, we illustrated the tumor suppressive effects of the newly identified Lactobacillus acidophilus DSMZ 20079 cell-free pentasaccharide against colon cancer cells. The chemical structure of the purified pentasaccharide was investigated by MALDI-TOF mass spectrum, 1D and 2D Nuclear Magnetic Resonance (NMR)...
February 21, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29465687/molecular-characterization-of-markers-associated-with-antimicrobial-resistance-in-neisseria-gonorrhoeae-identified-from-residual-clinical-samples
#7
Johan H Melendez, Justin Hardick, Mathilda Barnes, Perry Barnes, Christopher D Geddes, Charlotte A Gaydos
BACKGROUND: The emergence and spread of antimicrobial-resistant (AMR) Neisseria gonorrhoeae (NG) is a major public health concern. In the era of nucleic acid amplifications tests (NAATs), rapid and accurate molecular approaches are needed to help increase surveillance, guide antimicrobial stewardship, and prevent outbreaks. METHODS: Residual urethral swabs, collected prospectively in the Baltimore City Health Department during a six-month period, were analyzed by real-time PCR assays for NG DNA and AMR determinants to fluoroquinolones, penicillin, and extended-spectrum cephalosporins (ESCs)...
November 7, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29464837/isolated-vascular-v-lesions-in-liver-allografts-how-to-approach-this-unusual-finding
#8
H L Stevenson, M M Prats, K Isse, A Zeevi, Y Avitzur, V L Ng, A J Demetris
According to the Banff criteria for kidney allografts, isolated vascular or "v" lesions are defined as intimal inflammation, age-inappropriate fibro-intimal hyperplasia, or both, without the presence of associated interstitial T cell-mediated rejection (TCMR). In general, these lesions portend a worse outcome for kidney allografts, particularly in those where the "v" lesions are identified in patients with co-existent donor specific antibodies (DSA) or later after transplantation. Although affected arteries are rarely sampled in liver allograft biopsies, we identified 9 patients at a mean of 1,805 days post-transplantation and compared these to matched controls...
February 21, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29463473/poorly-controlled-homocystinuria-a-rare-cause-of-ischemic-priapism
#9
Mark Johnson, Elaine Murphy, Amr Raheem, David Ralph
We report on the 1st case of ischemic priapism secondary to poorly controlled homocystinuria. Homocystinuria is a rare, autosomal recessive, inherited disorder of metabolism that is caused by a deficiency of cystathionine synthase, leading to marked hyperhomocysteinemia. Arterial and/or venous thromboemboli are a major cause of mortality and morbidity in patients with homocystinuria. Untreated patients have a 50% chance of having a vascular event by 30 years of age. Increased homocysteine levels have been reported to upregulate prothrombotic factors and downregulate antithrombotic factors; in particular, increased homocystinuria has been found to downregulate nitric oxide (NO)...
February 17, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29462689/a-hydroxyl-peg-version-of-pegylated-liposomes-and-its-impact-on-anti-peg-igm-induction-and-on-the-accelerated-clearance-of-pegylated-liposomes
#10
Taro Shimizu, Amr S Abu Lila, Risako Fujita, Mizuki Awata, Munehira Kawanishi, Yosuke Hashimoto, Keiichiro Okuhira, Yu Ishima, Tatsuhiro Ishida
Surface decoration of liposomes with polyethylene glycol (PEG), PEGylation, is recognized as a method to bestow liposomes with a prolonged circulation time following intravenous administration. However, many reports have emphasized that a first dose of PEGylated liposomes (PL) elicits an anti-PEG IgM antibody response that can trigger a rapid systemic clearance of a second dose of PL via a phenomenon that is referred to as "accelerated blood clearance (ABC)." Such a phenomenon is usually observed with PL that has been modified with methoxy-PEG...
February 17, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29462212/epstein-barr-virus-nuclear-antigen-ebna-lp-is-essential-for-transforming-na%C3%A3-ve-b-cells-and-facilitates-recruitment-of-transcription-factors-to-the-viral-genome
#11
Agnieszka Szymula, Richard D Palermo, Amr Bayoumy, Ian J Groves, Mohammed Ba Abdullah, Beth Holder, Robert E White
The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral latency-associated protein produced after EBV infection of resting B cells. Its role in B cell transformation is poorly defined, but it has been reported to enhance gene activation by the EBV protein EBNA2 in vitro. We generated EBNA-LP knockout (LPKO) EBVs containing a STOP codon within each repeat unit of IR1. EBNA-LP-mutant EBVs established lymphoblastoid cell lines (LCLs) from adult B cells at reduced efficiency, but not from umbilical cord B cells, which died approximately two weeks after infection...
February 20, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29461808/tio-2-assisted-laser-desorption-ionization-mass-spectrometry-for-rapid-profiling-of-candidate-metabolite-biomarkers-from-antimicrobial-resistant-bacteria
#12
Rutan Zhang, Qin Qin, Baohong Liu, Liang Qiao
Antimicrobial resistance (AMR) is one of the most serious problems affecting public health and safety. It is crucial to understand antimicrobial resistance from molecular level. In this work, TiO2 assisted laser desorption/ionization (LDI) mass spectrometry (MS) was used for fast metabolites analysis from intact bacterial cells to discriminate different strains of bacteria and to detect AMR. With the mass spectra of bacterial metabolites by TiO2 -LDI MS, multivariable analysis was performed for bacterial identification to find out distinctive metabolites as potential biomarkers...
February 20, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29459508/hepatic-regeneration-and-reno-protection-by-fish-oil-nigella-sativa-oil-and-combined-fish-oil-nigella-sativa-volatiles-in-ccl-4-treated-rats
#13
Sahar Y Al-Okbi, Doha A Mohamed, Thanaa E Hamed, Amr E Edris, Karem Fouda
The aim of the present research was to investigate the effect of fish oil, crude Nigella sative oil and combined fish oil/Nigella sative volatile oil as hepato-regenerative and renal protective supplements. The oils were administered as emulsions to rat model with liver injury induced by CCl4 . Plasma activities of transaminases (AST and ALT) were evaluated as liver function indicators, while plasma creatinine and urea and creatinine clearance were determined as markers of kidney function. Plasma malondialdehyde (MDA), nitrite (NO) and tumor necrosis factor-α (TNF-α) were estimated to assess the exposure to oxidative stress and subsequent inflammation...
February 19, 2018: Journal of Oleo Science
https://www.readbyqxmd.com/read/29457879/the-good-the-bad-and-the-ugly-of-luminex-donor-specific-cross-match
#14
M Chowdhry, R N Makroo, Y Thakur, V Sharma, M Singh, M Kumar
The presence of donor specific antibodies directed against human leukocyte antigen significantly influences renal transplant due to antibody mediated rejection (AMR). We performed the screening of pre-renal transplant patients for preformed anti HLA antibodies using Antihuman globulin augmented-CDC crossmatch (AHG-CDCXm), Luminex donor specific crossmatch (LumXm) and HLA antibody screening. Seven hundred and fifty four patients were assessed for LumXm. HLA antibody screening was possible in 325 out of 754 cases...
February 19, 2018: HLA
https://www.readbyqxmd.com/read/29452547/potential-value-of-circulating-microrna-126-and-microrna-210-as-biomarkers-for-type-2-diabetes-with-coronary-artery-disease
#15
K S Amr, H Abdelmawgoud, Z Y Ali, S Shehata, H M Raslan
BACKGROUND: Macrovascular complications are the main cause of morbidity and mortality among the diabetic patients. MicroRNAs (miRNAs), a family of small non-coding RNAs, play vital roles in the regulation of blood glucose level and the concurrent cardiovascular complications of type 2 diabetes. We hypothesized that plasma miR-126 and miR-210 are linked to coronary artery disease (CAD) in these diabetes patients. METHODS: Fasting blood samples were collected from 20 healthy volunteers and 100 patients with diabetes (54 patients without CAD and 46 patients with CAD)...
February 16, 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29451814/variability-in-asthma-quality-and-costs-in-children-with-different-medicaid-insurance-plans-in-maricopa-county
#16
Matthew Rank, Natalie Landman, Gevork Harootunian, Michelle Winscott, Neil Jain, Keith Frey, Gena Wilson, Rupali Drewek, Lilia Parra-Roide, Charlton Wilson, Robert Smoldt, Denis Cortese
OBJECTIVE: To describe the variation in asthma quality and costs among children with different Medicaid insurance plans. METHODS: We used 2013 data from the Center for Health Information and Research, which houses a database that includes individuals who have Medicaid insurance in Arizona. We analyzed children ages 2-17 years-old who lived in Maricopa County, Arizona. Asthma medication ratio (AMR, a measure of appropriate asthma medication use), outpatient follow-up within 2 weeks after asthma-related hospitalization (a measure of continuity of care), asthma-related hospitalizations, and all emergency department (ED) visits were the primary quality metrics...
February 16, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29451003/escherichia-coli-isolates-from-femoral-bone-marrow-of-broilers-exhibit-diverse-pheno-and-genotypic-characteristics-that-do-not-correlate-with-macroscopic-lesions-of-bacterial-chondronecrosis-with-osteomyelitis-bco
#17
Barbara Gaußmann, Claudia Hess, Beatrice Grafl, Mercedes Kovacs, Salome Troxler, Beatrix Stessl, Michael Hess, Surya Paudel
The pheno- and genotypic relatedness among Escherichia coli isolates from broilers with and without macroscopic lesions on the femoral head were investigated. In total, 219 isolates obtained from the bone marrow were characterized by serotyping, antimicrobial resistance profiles (AMR), phylogenetic grouping, detection of virulence-associated genes (VAG) and pulsed-field gel electrophoresis (PFGE). Serotyping revealed that 48.4% of the isolates were assigned to one of the three serotypes (O78:K80: 21.0%, O2:K1: 18...
February 16, 2018: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/29450670/acetylsalicylic-acid-enhance-tolerance-of-phaseolus-vulgaris-l-to-chilling-stress-improving-photosynthesis-antioxidants-and-expression-of-cold-stress-responsive-genes
#18
Mona H Soliman, Aisha A M Alayafi, Amr A El Kelish, Abdelghafar M Abu-Elsaoud
BACKGROUND: High and low temperatures constitute the most damaging type of abiotic stress and limit the survival, and productivity of plants. The present study aimed to evaluate the role of exogenous applications of acetylsalicylic acid (ASA) in reducing the deleterious effects of cold stress. Phaseolus vulgaris L. seedlings were treated with foliar-sprayed ASA at concentrations of 0-3 mM and then subjected to chilling stress at 4 °C for 2 or 4 days. RESULTS: Growth, photosynthesis, biochemical alterations, oxidative damage and antioxidant enzyme activities as well as the expression of cold-responsive genes (CBF3-COR47), were monitored during the experiment...
February 15, 2018: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/29449173/exopolysaccharide-production-from-bacillus-velezensis-ky471306-using-statistical-experimental-design
#19
Saad A M Moghannem, Mohamed M S Farag, Amr M Shehab, Mohamed S Azab
Exopolysaccharide (EPS) biopolymers produced by microorganisms play a crucial role in the environment such as health and bio-nanotechnology sectors, gelling agents in food and cosmetic industries in addition to bio-flocculants in the environmental sector as they are degradable, nontoxic. This study focuses on the improvement of EPS production through manipulation of different culture and environmental conditions using response surface methodology (RSM). Plackett-Burman design indicated that; molasses, yeast extract and incubation temperature are the most effective parameters...
January 18, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29441167/is-this-a-worrisome-red-eye-episcleritis-in-the-primary-care-setting
#20
Amr Salama, Arwa Elsheikh, Richard Alweis
Episcleritis is the inflammation of the thin, loose, highly vascular connective tissue layer that lies between the conjunctiva and sclera. Incidence is less than 1/1000. It is more common in women and those between 40 and 50 years of age. Most cases are idiopathic. It is classified into simple and nodular. Most attacks resolve within 1-3 months. The nodular type tends to be more recurrent and painful. It presents with acute onset of redness, lacrimation, and photophobia. The diagnosis of is essentially clinical, and eye pain or tenderness should raise the concern for scleritis...
2018: Journal of Community Hospital Internal Medicine Perspectives
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