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https://www.readbyqxmd.com/read/29691332/clinically-relevant-plasmid-host-interactions-indicate-that-transcriptional-and-not-genomic-modifications-ameliorate-fitness-costs-of-klebsiella-pneumoniae-carbapenemase-carrying-plasmids
#1
Michelle M C Buckner, Howard T H Saw, Rachael N Osagie, Alan McNally, Vito Ricci, Matthew E Wand, Neil Woodford, Alasdair Ivens, Mark A Webber, Laura J V Piddock
The rapid dissemination of antimicrobial resistance (AMR) around the globe is largely due to mobile genetic elements, such as plasmids. They confer resistance to critically important drugs, including extended-spectrum beta-lactams, carbapenems, and colistin. Large, complex resistance plasmids have evolved alongside their host bacteria. However, much of the research on plasmid-host evolution has focused on small, simple laboratory plasmids in laboratory-adapted bacterial hosts. These and other studies have documented mutations in both host and plasmid genes which occur after plasmid introduction to ameliorate fitness costs of plasmid carriage...
April 24, 2018: MBio
https://www.readbyqxmd.com/read/29691095/role-of-hydroxyurea-as-an-adjuvant-treatment-after-gamma-knife-radiosurgery-for-atypical-who-grade-ii-meningiomas
#2
Khalid Abdel Karim, Amr El Shehaby, Reem Emad, Wael Reda, Manal El Mahdy, Ramy Ghali, Ahmed Nabeel
No abstract text is available yet for this article.
April 21, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29691094/first-experience-of-the-egyptian-national-cancer-institute-using-the-robot-assisted-laparoscopic-approach-in-radical-hysterectomies-for-cervical-cancer
#3
Ashraf Saad Zaghloul, Ahmed Mahmoud El-Minawi, Mohamed Atef ElKordy, Amr Kamal Younes, Ahmed Mostafa Mahmoud, Waleed Mohamed Fadlalla, Gamal Amira Mohamed
AIM OF WORK: Robotics in surgery led to an improvement of visualization, a better handling of tissues and better suturing. This study aimed to document the first experience of the Egyptian National Cancer Institute (NCI) using the robot-assisted laparoscopic approach in radical hysterectomies for cervical cancer and to highlight observed advantages, disadvantages, morbidity and oncological outcomes. PATIENTS AND METHODS: Data of cases that had either early cervical cancer (stage IB-IIA1 with a tumor ≥2 cm) or locally advanced cervical cancer (Stage IIA2-IIB after chemo-radiotherapy) were collected prospectively...
April 21, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29690914/klk10-exon-3-unmethylated-pcr-product-concentration-a-new-potential-early-diagnostic-marker-in-ovarian-cancer-a-pilot-study
#4
Mustafa A El Sherbini, Amal A Mansour, Maha M Sallam, Emtiaz A Shaban, Zeinab A Shehab ElDin, Amr H El-Shalakany
BACKGROUND: KLK10 exon 3 hypermethylation correlated to tumor-specific lack of KLK10 expression in cancer cell lines and primary tumors. In the present study we investigate the possible role of KLK10 exon 3 methylation in ovarian tumor diagnosis and prognosis. RESULTS: Qualitative methylation-specific PCR (MSP) results did not show statistically significant differences in patient group samples (normal and tumor) where all samples were positive only for the unmethylated-specific PCR except for two malignant samples that were either doubly positive (serous carcinoma) or doubly negative (Sertoli-Leydig cell tumor) for the two MSP tests...
April 24, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29690341/systematics-distribution-and-ecological-analysis-of-rodents-in-jordan
#5
Zuhair S Amr, Mohammad A Abu Baker, Mazin Qumsiyeh, Ehab Eid
Distributional and ecological data were given to all rodents of Jordan. The rodent fauna of Jordan consists of 28 species with 20 genera in eight families (Cricetidae, Dipodidae, Gliridae, Hystricidae, Muridae, Myocastoridae, Sciuridae,and Spalacidae), including four introduced species.Keys for families and species were provided, along with diagnosis for each species and cranial illustrations for most species. Habitat preference and zoogeographic affinities of rodents in Jordan wereanalyzed, as well as their status and conservation...
March 18, 2018: Zootaxa
https://www.readbyqxmd.com/read/29685448/comparison-of-annual-and-regional-variation-in-multidrug-resistance-using-various-classification-metrics-for-generic-escherichia-coli-isolated-from-chicken-abattoir-surveillance-samples-in-canada
#6
Melissa C MacKinnon, David L Pearl, Carolee A Carson, E Jane Parmley, Scott A McEwen
Antimicrobial resistance (AMR) and related multidrug resistance (MDR) are important global public health issues. The Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS) conducts surveillance of AMR in enteric bacteria and monitors MDR. However, the analysis of MDR is complicated by the lack of consensus for MDR definitions. The objectives were to describe the most common resistance patterns in generic E. coli isolates from chicken cecal samples and determine the impact of using different MDR metrics for analysis of annual and regional variation in MDR...
June 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29685438/antimicrobials-usage-assessments-in-commercial-poultry-and-local-birds-in-north-central-nigeria-associated-pathways-and-factors-for-resistance-emergence-and-spread
#7
N B Alhaji, A E Haruna, B Muhammad, M K Lawan, T O Isola
The World Health Organization's Global Action Plan on antimicrobial resistance (AMR) recommended monitoring of antimicrobial use (AMU) through surveillance and research to help mitigate AMR. This survey was aimed at assessing poultry owners' knowledge/awareness and practices regarding AMU, identified pathways for AMR emergence and spread in small-scale commercial poultry farms and free-range local bird flocks in North-central Nigeria. An interview questionnaire-based cross-sectional study was conducted on commercial poultry farmers and local bird flock keepers in 2017...
June 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29685200/scrub-typhus-re-emergence-in-india-contributing-factors-and-way-forward
#8
Jai Ranjan, John Antony Jude Prakash
Scrub typhus is a mite borne infectious disease which has re-emerged in India in the 3rd millennium after years of quiescence. In this review, the authors hypothesize the various factors responsible for resurgence of this disease. The main drivers that could have contributed to the upsurge in scrub typhus cases in past two decades are changes in land use land cover (LULC) and urbanisation which are; as a result of the population explosion, causing a strain on sanitation and also increased diversion of forest land for agricultural use...
June 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29684369/alpha-fetoprotein-in-pericardial-peritoneal-and-pleural-fluids-a-body-fluid-matrix-evaluation
#9
William E Owen, Joshua J H Hunsaker, Jonathan R Genzen
OBJECTIVES: Alpha-fetoprotein (AFP) measurement in pericardial, peritoneal (ascites), and pleural fluids is sometimes requested by clinicians as supportive evidence in the evaluation of suspected malignancy. As commercially available, Food and Drug Administration (FDA)-cleared AFP assays are not validated for these fluid types, laboratories must complete additional validation studies to comply with regulatory requirements for body fluid testing. The objective of this study was therefore to conduct a matrix evaluation for these body fluid types using the Beckman Access AFP assay on the UniCel DxI 800 immunoassay system...
April 20, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29682682/molecular-and-clinical-roles-of-incretin-based-drugs-in-patients-with-heart-failure
#10
REVIEW
Bassant Orabi, Rasha Kaddoura, Amr S Omar, Cornelia Carr, Abdulaziz Alkhulaifi
Glucagon-like peptide-1 (GLP-1) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors produce some beneficial and deleterious effects in diabetic patients not mediated by their glycemic lowering effects, and there is a need for better understanding of the molecular basis of these effects. They possess antioxidant and anti-inflammatory effects with some direct vasodilatory action (animal and human trial data) that may indirectly influence heart failure (HF). Unlike GLP-1R agonists, signaling for HF adverse effects was observed with two DPP-4 inhibitors, saxagliptin and alogliptin...
April 23, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29681097/philtrum-length-and-intercommissural-distance-measurements-at-mixed-dentition-period
#11
Mostafa Mostafa, Nehal Hassib, Inas Sayed, Amany Neamat, Magda Ramzy, Tarek El-Badry, Hisham ElGabry, Haidy Salem, Nada Omar, Amira Ismail, Yousra Ibrahim, Amr Shebaita, Ahmed Allam, Magdy Mostafa
Anthropometric measurements of the lip and mouth are of great importance in clinical dysmorphology as well as reconstructive plastic surgery. In this study, the philtrum length (PhL) and intercommissural distance (ICmD) nomograms for Egyptian children in the mixed dentition period were established. A group of 1,338 Egyptian students in primary schools (735 boys and 603 girls) were included in the study. The students were at mixed dentition period and their ages ranged from 7 to 12 years. Anthropometric norms of PhL and ICmD were developed with significant sex difference in certain groups...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29680695/microbiological-quality-and-antimicrobial-resistance-characterization-of-salmonella-spp-in-fresh-milk-value-chains-in-ghana
#12
Angela Parry-Hanson Kunadu, Mark Holmes, Eric L Miller, Andrew J Grant
Consumer perception of poor hygiene of fresh milk products is a major barrier to promotion of milk consumption as an intervention to alleviate the burden of malnutrition in Ghana. Fresh milk is retailed raw, boiled, or processed into unfermented cheese and spontaneously fermented products in unlicensed outlets. In this study, we have determined microbiological quality of informally retailed fresh milk products and characterized the genomic diversity and antimicrobial resistance (AMR) patterns of non-typhoidal Salmonella (NTS) in implicated products...
April 14, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29678910/serotype-diversity-and-antimicrobial-resistance-among-salmonella-enterica-isolated-from-patients-at-an-equine-referral-hospital
#13
I M Leon, S D Lawhon, K N Norman, D S Threadgill, N Ohta, J Vinasco, H M Scott
Although Salmonella enterica can produce life-threatening colitis in horses, certain serotypes are more commonly associated with clinical disease. Our aim was to evaluate the proportional morbidity attributed to different serotypes, as well as phenotypic and genotypic antimicrobial resistance (AMR) of Salmonella isolated from patients at an equine referral hospital in the southern United States. Two-hundred-fifty-five Salmonella isolates were obtained from clinical samples of patients admitted to the hospital between 2007 and 2015...
April 20, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29678695/the-imd-pathway-regulates-lysozyme-like-proteins-llps-in-the-silkmoth-antheraea-mylitta
#14
Valluri V Satyavathi, Amr A Mohamed, Swetha Kumari, Dadala M Mamatha, Bernard Duvic
Lysozyme-like proteins (LLPs) are members of the glycoside hydrolase family 22 (CAZY GH22). Unlike conventional c-type lysozymes (EC 3.2.1.17), LLPs lack specific catalytic amino acid residues essential for muramidase activity. Previous reports indicated upregulation of LLPs upon bacterial infection in the wild silkworm, Antheraea mylitta as well as in the domesticated silkworm, Bombyx mori. In the present work, we studied the signaling pathways mediating the production of LLPs using RNA interference-mediated knockdown of Spätzle, Relish and STAT, the key regulators of Toll, IMD (Immune deficiency) and JAK/STAT pathways, respectively...
April 17, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29678503/caffeine-inhibits-stat1-signaling-and-downregulates-inflammatory-pathways-involved-in-autoimmunity
#15
Merve Iris, Pei-Suen Tsou, Amr H Sawalha
Caffeine is a widely consumed pharmacologically active product. We focused on characterizing immunomodulatory effects of caffeine on peripheral blood mononuclear cells. Caffeine at high doses showed a robust downregulatory effect on cytokine activity and genes related to several autoimmune diseases including lupus and rheumatoid arthritis. Dose-dependent validation experiments showed downregulation at the mRNA levels of key inflammatory genes including STAT1, TNF, and PPARG. TNF and PPARG were suppressed even with the lowest caffeine dose tested, which corresponds to the serum concentration of caffeine after administration of one cup of coffee...
April 17, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29674796/prescriber-and-dispenser-perceptions-about-antibiotic-use-in-acute-uncomplicated-childhood-diarrhea-and-upper-respiratory-tract-infection-in-new-delhi-qualitative-study
#16
Anita Kotwani, P C Joshi, Urmila Jhamb, Kathleen Holloway
OBJECTIVE: The objective of the study was to explore the prescribing practices, knowledge, and attitudes of primary care doctors and community pharmacists, regarding antibiotic use in acute upper respiratory tract infections (URTI) and diarrhea in children to better understand causes of misuse and identify provider suggestions to change such behavior. MATERIALS AND METHODS: Two focus group discussions (FGDs) each were conducted with primary care government doctors (GDs), private general practitioners (GPs), pediatricians, and community pharmacists in Delhi...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29673977/epizootics-of-pseudomonas-anguilliseptica-among-cultured-seabream-sparus-aurata-populations-control-and-treatment-strategies
#17
Amr Fadel, Mahmoud Mabrok, Salah Aly
The present study was investigating the clinical pictures, prevalence, as well as the ecological conditions associated with Pseudomonas anguilliseptica outbreaks in four cultured seabream (Sparus aurata) farms at different localities in Egypt during the winter season of 2016. The phenotypic and genotypic patterns of pseudomonas isolates were investigated. The existence of intraspecific heterogeneity among different isolates was analyzed using Restriction fragment length polymorphism (RFLP) technique. Attempts on disease control using antibiogram or dietary supplement were also considered...
April 16, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29672633/design-synthesis-dft-docking-studies-and-adme-prediction-of-some-new-coumarinyl-linked-pyrazolylthiazoles-potential-standalone-or-adjuvant-antimicrobial-agents
#18
Sunil Kumar, Vikram Saini, Indresh K Maurya, Jayant Sindhu, Mukesh Kumari, Ramesh Kataria, Vinod Kumar
The control of antimicrobial resistance (AMR) seems to have come to a dead end. The major consequences of the use and abuse of antibacterial drugs are the development of resistant strains due to genetic mutability of both pathogenic and nonpathogenic microorganisms. We, herein, report the synthesis, characterization and biological activities of coumarin-thiazole-pyrazole (CTP) molecular hybrids with an effort to explore and overcome the increasing antimicrobial resistance. The compounds were characterized by analyzing their IR, Mass, 1H and13C NMR spectral data and elemental analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29666259/shared-epitope-aryl-hydrocarbon-receptor-crosstalk-underlies-the-mechanism-of-gene-environment-interaction-in-autoimmune-arthritis
#19
Jiaqi Fu, Sarah V Nogueira, Vincent van Drongelen, Patrick Coit, Song Ling, Edward F Rosloniec, Amr H Sawalha, Joseph Holoshitz
The susceptibility to autoimmune diseases is affected by genetic and environmental factors. In rheumatoid arthritis (RA), the shared epitope (SE), a five-amino acid sequence motif encoded by RA-associated HLA-DRB1 alleles, is the single most significant genetic risk factor. The risk conferred by the SE is increased in a multiplicative way by exposure to various environmental pollutants, such as cigarette smoke. The mechanism of this synergistic interaction is unknown. It is worth noting that the SE has recently been found to act as a signal transduction ligand that facilitates differentiation of Th17 cells and osteoclasts in vitro and in vivo...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29665886/antimicrobial-resistance-from-basic-science-to-translational-innovation
#20
Jun Lin
The rise in antimicrobial resistance (AMR) poses a major threat to animal agriculture and human health. To summarize and update current and emerging AMR issues that are significant for animal health and food safety, this issue presents a virtual AMR symposium consisting of seven review papers. These reviews cover a newly described AMR mechanism in Campylobacter, effects of AMR and microbiome on Campylobacter infection, plasmid-mediated colistin resistance in food-producing animals, the impact of point source or antibiotic residues on the environmental resistome, and potential factors influencing horizontal gene transfer in the intestines of food animals...
December 2017: Animal Health Research Reviews
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