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sleep apnea cardiovascular disease

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https://www.readbyqxmd.com/read/29352093/excessive-daytime-sleepiness-independently-predicts-increased-cardiovascular-risk-after-myocardial-infarction
#1
Jiang Xie, Fatima H Sert Kuniyoshi, Naima Covassin, Prachi Singh, Apoor S Gami, C Anwar A Chahal, Virend K Somers
BACKGROUND: Excessive daytime sleepiness (EDS), a common symptom among patients with sleep-disordered breathing, is closely associated with the development of cardiovascular diseases, but its long-term prognostic value is not completely understood. The aim of this study was to investigate whether EDS would be an independent prognostic factor after myocardial infarction. METHODS AND RESULTS: We prospectively recruited 112 post-myocardial infarction patients. The Epworth Sleepiness Scale was completed before polysomnography, and EDS was defined as a score ≥11...
January 19, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29337458/-pulmonary-diseases-asthma-copd-and-sleep-apnea-syndrome
#2
Béatrice Duxbury, Émilie Chappuis-Gisin, Salim Chucri, Jean-Paul Janssens
Among the novelties described in the management of pulmonary disorders during the year 2017, we chose to describe three. First, the indication for inhaled glucocorticosteroids (ICS) in COPD has been revisited, because of their relationship with an increased occurence of pneumonia : ICS are now recommended only in severe COPD (GOLD D) with frequent exacerbations as second line treatment. Secondly, azithromycine has shown very promising results in poorly controlled severe asthma, with a significant impact on symptoms and exacerbations...
January 10, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29322708/high-prevalence-of-obstructive-sleep-apnea-among-people-with-type-2-diabetes-mellitus-in-a-tertiary-care-center
#3
Vijay Viswanathan, Indira Priyadarshini Ramalingam, Nagarajan Ramakrishnan
Purpose: Untreated obstructive sleep apnea (OSA) is a risk factor for hypertension and cardiac events, and is associated with increased mortality. Recent studies indicate that majority of people with type 2 diabetes also has OSA. The aim of this study was to assess the prevalence and severity of OSA and risk factors contributing to it among people with chronic and severe type 2 diabetes. Methods: A total of 203 people with type 2 diabetes (mean age: 54±8 years, 145 males, 58 females, HbA1c ≥7% [53mmol/mol]) attending a diabetes specialty hospital were included in the study; all were subjected to comprehensive diabetic evaluation and Apnea Hypopnea Index (AHI) was used to evaluate OSA...
November 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29315434/recognizable-clinical-subtypes-of-osa-across-a-worldwide-sleep-center-population-a-cluster-analysis
#4
Brendan T Keenan, Jinyoung Kim, Bhajan Singh, Lia Bittencourt, Ning-Hung Chen, Peter A Cistulli, Ulysses Magalang, Nigel McArdle, Jesse W Mindel, Bryndis Benediktsdottir, Erna Sif Arnardottir, Lisa Kristin Prochnow, Thomas Penzel, Bernd Sanner, Richard Schwab, Chol Shin, Kate Sutherland, Sergio Tufik, Greg Maislin, Thorarinn Gislason, Allan I Pack
Study Objectives: A recent study of moderate-severe obstructive sleep apnea (OSA) patients in Iceland identified 3 clinical clusters based on symptoms and comorbidities. We sought to verify this finding in a new cohort in Iceland and examine the generalizability of OSA clusters in an international ethnically diverse cohort. Methods: Using data on 972 moderate-severe OSA patients [apnea-hypopnea index (AHI) ≥15 events/hour] recruited from the Sleep Apnea Global Interdisciplinary Consortium (SAGIC) we performed a latent class analysis of 18 self-reported symptom variables, hypertension, cardiovascular disease and diabetes...
January 5, 2018: Sleep
https://www.readbyqxmd.com/read/29306907/new-aspects-in-the-pathomechanism-of-diseases-of-civilization-particularly-psychosomatic-disorders-part-2-chronic-hypocapnia-and-hypercapnia-in-the-medical-practice
#5
Andras Sikter, Zoltan Rihmer, Roberto de Guevara
The authors seek to find new connections between recent results of biology and older theories. This paper aims to assemble the jigsaw puzzle. The theoretical background of the hypothesis was described in the previous issue of the journal (Sikter et al. 2017a). Human stress response often coexists with persistent hypocapnia or hypercapnia - developing via psychosomatic pathomechanism - which can lead to mental and psychosomatic illnesses. Chronic hypocapnia mainly generates hyperarousal disorders which may be reversible for an extended time, however, vicious cycles may start when hypoxia and/or severe somatic diseases are simultaneously present (commonly in the elderly), which conditions often end with death without medical help...
September 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/29296051/effects-of-continuous-positive-airway-pressure-on-anxiety-depression-and-major-cardiac-and-cerebro-vascular-events-in-obstructive-sleep-apnea-patients-with-and-without-coronary-artery-disease
#6
Ming-Chung Lee, Yu-Chih Shen, Ji-Hung Wang, Yu-Ying Li, Tzu-Hsien Li, En-Ting Chang, Hsiu-Mei Wang
Objective: Obstructive sleep apnea (OSA) is associated with bad cardiovascular outcomes and a high prevalence of anxiety and depression. This study investigated the effects of continuous positive airway pressure (CPAP) on the severity of anxiety and depression in OSA patients with or without coronary artery disease (CAD) and on the rate of cardio- and cerebro-vascular events in those with OSA and CAD. Materials and Methods: This prospective study included patients with moderate-to-severe OSA, with or without a recent diagnosis of CAD; all were started on CPAP therapy...
October 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29285942/-non-alcoholic-fatty-liver-disease-as-a-component-of-the-metabolic-syndrome-and-its-causal-correlations-with-other-extrahepatic-diseases
#7
Tamás Halmos, Ilona Suba
Non-alcoholic fatty liver disease is the most common non-infectious chronic liver-disease in our age, and is a spectrum of all the diseases associated with increased fat accumulation in the hepatocytes. Its development is promoted by sedentary life-style, over-feeding, and certain genetic predisposition. Prevalence in the adult population, even in Hungary is ~30%. In a part of cases, this disease may pass into non-alcoholic steatohepatitis, later into fibrosis, rarely into primary hepatocellular cancer. Fatty liver is closely and bidirectionally related to the metabolic syndrome and type 2 diabetes, and nowadays there is a general consensus that fatty liver is the hepatic manifestation of the metabolic sycndrome...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29283409/omentin-a-novel-adipokine-in-respiratory-diseases
#8
REVIEW
Yan Zhou, Bo Zhang, Caixia Hao, Xiaoting Huang, Xiaohong Li, Yanhong Huang, Ziqiang Luo
Adipokines, secreted by the adipose tissue, are extensively involved in the regulation and maintenance of various physiological and pathological processes, including insulin sensitivity, energy expenditure, glucose and lipid metabolism, inflammatory activity, neuroendocrine activity, immunity, cancer, homeostasis, angiogenesis, cardiovascular function, breeding and bone metabolism, and all functions of the endocrine-reproductive system axis. Omentin is a recently identified adipokine, which has become a research hotspot due to its pleiotropic effects on various diseases...
December 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29277633/which-place-of-pharmacological-approaches-beyond-continuous-positive-airway-pressure-to-treat-vascular-disease-related-to-obstructive-sleep-apnea
#9
REVIEW
Elodie Gautier-Veyret, Jean-Louis Pépin, Françoise Stanke-Labesque
Obstructive sleep apnea (OSA) is characterized by recurrent episodes of partial or complete upper airway obstruction, occurring during sleep, leading to chronic intermittent hypoxia (IH), which harms the cardiovascular system. OSA is associated with both functional and structural vascular alterations that contribute to an increased prevalence of fatal and non-fatal cardiovascular events. OSA is a heterogeneous disease with respect to the severity of hypoxia, the presence of daytime symptoms, obesity, and cardiovascular comorbidities...
December 22, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29259576/obstructive-sleep-apnea-phenotypes-and-markers-of-vascular-disease-a-review
#10
REVIEW
Alberto R Ramos, Pedro Figueredo, Shirin Shafazand, Alejandro D Chediak, Alexandre R Abreu, Salim I Dib, Carlos Torre, Douglas M Wallace
Obstructive sleep apnea (OSA) is a chronic and heterogeneous disorder that leads to early mortality, stroke, and cardiovascular disease (CVD). OSA is defined by the apnea-hypopnea index, which is an index of OSA severity that combines apneas (pauses in breathing) and hypopneas (partial obstructions in breathing) associated with hypoxemia. Yet, other sleep metrics (i.e., oxygen nadir, arousal frequency), along with clinical symptoms and molecular markers could be better predictors of stroke and CVD outcomes in OSA...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29258810/sex-differences-in-sleep-apnea-and-comorbid-neurodegenerative-diseases
#11
Brina Snyder, Rebecca L Cunningham
Sleep apnea is a disorder, which increasingly affects people worldwide. Whether the associated hypoxic events during sleep are central or obstructive in origin, the end result is excessive daytime sleepiness and an increased risk for several comorbidities, such as cardiovascular and neurodegenerative disorders. Sleep apnea is diagnosed more frequently in men than women, suggesting a role of sex hormones in the pathology of the disease. Furthermore, there are sex differences in the development and progression of comorbid diseases associated with sleep apnea...
December 16, 2017: Steroids
https://www.readbyqxmd.com/read/29241747/pathophysiology-of-the-metabolic-syndrome
#12
Emma McCracken, Monica Monaghan, Shiva Sreenivasan
The metabolic syndrome-otherwise called syndrome X, insulin resistance syndrome, Reaven syndrome, and "the deadly quartet"-is the name given to the aggregate of clinical conditions comprising central and abdominal obesity, systemic hypertension, insulin resistance (or type 2 diabetes mellitus), and atherogenic dyslipidemia. It is a prothrombotic and proinflammatory state characterized by increased inflammatory cytokine activity. In addition to inflammatory dermatoses such as psoriasis, lichen planus, and hidradenitis suppurativa, metabolic syndrome is also commonly associated with accelerated atherosclerotic cardiovascular disease, hyperuricemia/gout, chronic kidney disease, and obstructive sleep apnea...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29231011/-research-progress-of-the-relationship-between-sunds-and-osahs
#13
REVIEW
Y D Wu, L Y Zhang, J D Cheng
Sudden unexplained nocturnal death syndrome (SUNDS) is always a difficulty in forensic medicine researches. Although the development of molecular genetics promotes the etiologic study of SUNDS, the pathogenesis of most such cases is still unclear. Sleep apnea syndrome (SAS) is one of the common forms of sleep disorders, and obstructive sleep apnea hypopnea syndrome (OSAHS) is the most common. In recent years, some domestic and international researches show that OSAHS is related to the development of cardiovascular disease, which may cause cardiac arrhythmia, even sudden death...
February 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29212465/association-of-24%C3%A2-h-systolic-blood-pressure-variability-and-cardiovascular-disease-in-patients-with-obstructive-sleep-apnea
#14
Xiao Ke, Yan Sun, Rongfeng Yang, Jiawen Liang, Shaoyun Wu, Chengheng Hu, Xing Wang
BACKGROUND: To evaluate association of 24 h-systolic blood pressure (SBP) variability and obstructive sleep apnea (OSA) as defined by the apnea-hypopnea index ≥5/h; and association of 24 h-SBP variability and prevalent cardiovascular disease (CVD) in OSA patients. METHODS: Participants underwent polysomongraphy to evaluate the presence of OSA, and 24 h-ambulatory blood pressure monitoring was applied to evaluate 24 h-SBP variability as indexed by weighted 24 h-standard deviation (SD) of SBP...
December 6, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29198297/sleep-apnea-in-patients-hospitalized-with-acute-ischemic-stroke-underrecognition-and-associated-clinical-outcomes
#15
Nura Festic, David Alejos, Vikas Bansal, Lesia Mooney, Paul A Fredrickson, Pablo R Castillo, Emir Festic
STUDY OBJECTIVES: To evaluate clinical recognition of sleep apnea and related outcomes in patients hospitalized with acute ischemic stroke. METHODS: A retrospective study of all patients hospitalized with acute ischemic stroke from April 2008 to December 2014. The primary predictor and outcome variables were sleep apnea and hospital mortality, respectively. Secondary outcomes were mechanical ventilation, hospital length of stay, and the survivor's functional level by the modified Rankin scale...
November 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29184787/correlation-of-self-reported-urologic-symptoms-with-systemic-health-conditions-in-minority-men
#16
Sarah Coleman Vij, Andrew Turk, Tianming Gao, Daniel A Shoskes
Background: To investigate the correlation between presence and severity of urologic symptoms and self-reported systemic health conditions in minority men. Methods: Questionnaires were distributed at a Men's Minority Health Fair. Urologic symptoms were assessed with the International Prostate Symptom Score (IPSS), Sexual Health Inventory for Men (SHIM) and NIH Chronic Prostatitis Symptom Score (CPSI). Each was graded as absent/mild [0], moderate [1] or severe [2] by standard criteria for each and totaled for a urologic score (US)...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29177626/non-surgical-treatment-of-obstructive-sleep-apnea-syndrome
#17
REVIEW
Xu Tingting, You Danming, Chen Xin
Obstructive sleep apnea syndrome (OSAS), a pervasive disease, is closely associated with complications such as cardiovascular diseases, neurocognitive diseases, and metabolic syndromes. Continuous positive airway pressure (CPAP) is the standard treatment for OSAS, with low compliance due to multifarious factors. The two other modes of ventilation, bi-level positive airway pressure (BPAP) and autotitrating positive airway pressure (APAP), which were developed from CPAP, are slightly different from CPAP in specific groups, as well as the corresponding treatment effect and compliance...
November 24, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29177130/sleep-disordered-breathing-and-spinal-cord-injury-challenges-and-opportunities
#18
Abdulghani Sankari, Jennifer L Martin, M Safwan Badr
Purpose of review: This paper focuses on the sleep disorders in patients with spinal cord injury (SCI/D), particularly mechanism of sleep disordered breathing (SDB) and challenges in diagnosis and management. Based on a review of recent literatures and studies the paper summarizes some main challenges with respect to management of SDB in patients with SCI; and what are the responsible mechanisms of disease? What are the barriers in diagnosing and treating SDB using standard treatment such as positive airway pressure (CPAP)?...
December 2017: Current Sleep Medicine Reports
https://www.readbyqxmd.com/read/29174957/alternatives-to-testosterone-therapy-a-review
#19
REVIEW
Eric M Lo, Katherine M Rodriguez, Alexander W Pastuszak, Mohit Khera
INTRODUCTION: Although testosterone therapy (TTh) is an effective treatment for hypogonadism, recent concerns regarding its safety have been raised. In 2015, the US Food and Drug Administration issued a warning about potential cardiovascular risks resulting from TTh. Fertility preservation is another reason to search for viable alternative therapies to conventional TTh, and in this review we evaluate the literature examining these alternatives. AIMS: To review the role and limitations of non-testosterone treatments for hypogonadism...
January 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29172793/impact-of-obstructive-sleep-apnea-on-blood-pressure-and-cardiovascular-risk-factors-in-japanese-men-a-cross-sectional-study-in-work-site-group
#20
Yuki Morinaga, Kiyoshi Matsumura, Yasuo Kansui, Satoko Sakata, Kenichi Goto, Yoshie Haga, Emi Oishi, Takunori Seki, Toshio Ohtsubo, Takanari Kitazono
It has been shown that obstructive sleep apnea (OSA) is related to hypertension and cardiovascular disease; however, the prevalence of OSA in general population and the impact of it on blood pressure especially in Japan has not been well determined. We have conducted a screening test for OSA from 2003 to 2011. In addition, a cross-sectional analysis was performed in 2012 to determine the association of OSA and cardiovascular risk factors in Japanese men (18-69 years of age; mean age, 44.4 ± 0.2). The study group consisted of 2208 male employees, and OSA was evaluated by using the 4% oxygen desaturation index and apnea-hypopnea index (AHI)...
November 27, 2017: Clinical and Experimental Hypertension: CHE
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