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Vascular Medicine Trial

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https://www.readbyqxmd.com/read/27871211/registry-and-health-insurance-claims-data-in-vascular-research-and-quality-improvement
#1
Christian-Alexander Behrendt, Franziska Heidemann, Henrik Christian Rieß, Konstanze Stoberock, Sebastian Eike Debus
The expansion of procedures in multidisciplinary vascular medicine has sparked a controversy regarding measures of quality improvement. In addition to primary registries, the use of health insurance claims data is becoming of increasing importance. However, due to the fact that health insurance claims data are not collected for scientific evaluation but rather for reimbursement purposes, meticulous validation is necessary before and during usage in research and quality improvement matters. This review highlights the advantages and disadvantages of such data sources...
November 22, 2016: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27852303/the-effects-of-nigella-sativa-on-thyroid-function-serum-vascular-endothelial-growth-factor-vegf-1-nesfatin-1-and-anthropometric-features-in-patients-with-hashimoto-s-thyroiditis-a-randomized-controlled-trial
#2
Mahdieh Abbasalizad Farhangi, Parvin Dehghan, Siroos Tajmiri, Mehran Mesgari Abbasi
BACKGROUND: Hashimoto's thyroiditis is an autoimmune disorder and the most common cause of hypothyroidism. The use of Nigella sativa, a potent herbal medicine, continues to increase worldwide as an alternative treatment of several chronic diseases including hyperlipidemia, hypertension and type 2 diabetes mellitus (T2DM). The aim of the current study was to evaluate the effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis...
November 16, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27814288/evidence-based-hemorheology-does%C3%A2-it%C3%A2-exist-%C3%A2-applying-evidence-from%C3%A2-clinical-studies-to-the-individual-patient
#3
António Vaz Carneiro
Clinicians are used to treat individual patients, and therefore may feel that clinical trials and systematic reviews do not give information for optimal treatment of the single patient.Evidence Based Medicine (EBM) is the integration of research evidence (from clinically relevant studies conducted using sound methodology) with clinical expertise (clinician's cumulated experience) and patient values (personal preferences and unique concerns and expectations).The practical steps of EBM include: 1) assess the patient, 2) ask the clinical question, 3) acquire the evidence, 4) critically appraise the evidence, 5) apply the results to the patient and 6) self-evaluate one's practice...
November 4, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27806355/effects-of-lowering-dialysate-calcium-concentration-on-carotid-intima-media-thickness-and-aortic-stiffness-in-patients-undergoing-maintenance-hemodialysis-a-prospective-study
#4
Zhangxiu He, Lei Cui, Chunyuan Ma, Hong Yan, Tanyong Ma, Lirong Hao
BACKGROUND AND AIM: The study aimed to prospectively evaluate the effects of lowering the dialysate calcium concentration (DCa) to 1.25 mmol/l on Chinese patients undergoing maintenance hemodialysis (MHD), which are largely unknown to date. METHODS: A singer-center, prospective, randomized trial was conducted for 2 years. The DCa in one group was decreased from 1.5 to 1.25 mmol/l but there was no change in the other group. The clinical outcomes, biochemical parameters, medicine treatments and markers of vascular change were compared among the 2 groups at different time intervals...
November 2, 2016: Blood Purification
https://www.readbyqxmd.com/read/27771711/clinical-therapeutic-effects-of-aspirin-in-combination-with-fufang-danshen-diwan-a-traditional-chinese-medicine-formula-on-coronary-heart-disease-a-systematic-review-and-meta-analysis
#5
Jianchun Huang, Xiaojun Tang, Fangxing Ye, Junhui He, Xiaolong Kong
BACKGROUND/AIMS: Coronary heart disease is characterized by vascular stenosis or occlusion resulting in myocardial ischemia, hypoxia and necrosis. In China, the combination of aspirin and Fufang Danshen Diwan (FDD), a traditional Chinese medicine formula, has been suggested in the treatment of coronary heart disease. There have been several studies comparing the effectiveness of aspirin alone and in combination with FDD to treat coronary artery disease; however, it remains unclear whether combined aspirin therapy is superior...
October 24, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27770853/external-mechanical-devices-and-vascular-surgery-for-erectile-dysfunction
#6
Landon W Trost, Ricardo Munarriz, Run Wang, Allen Morey, Laurence Levine
INTRODUCTION: The field of sexual medicine is continuously advancing, with novel outcomes reported on a regular basis. Given the rapid evolution, updated guidelines are essential to inform practicing clinicians on best practices. AIM: To summarize the current literature and provide clinical guidelines on penile traction therapy, vacuum erection devices, and penile revascularization. METHODS: A consensus panel was held with leading sexual medicine experts during the 2015 International Consultation on Sexual Medicine (ICSM)...
November 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27755130/twin-pregnancy-complicated-by-selective-growth-restriction
#7
Rosemary Townsend, Asma Khalil
PURPOSE OF REVIEW: Selective intrauterine growth restriction (sIUGR) in twin pregnancies presents a complex management problem for the fetal medicine specialist. This review summarizes what is currently known about sIUGR pathophysiology, particularly in monochorionic pregnancies and looks at the results of early trials of fetal intervention in high-risk sIUGR pregnancies. RECENT FINDINGS: sIUGR in monochorionic pregnancies is due to unequal placental sharing, but the clinical outcome is determined by the characteristics of the placental vascular anastomoses...
October 15, 2016: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27705748/cornus-mas-l-cornelian-cherry-an-important-european-and-asian-traditional-food-and-medicine-ethnomedicine-phytochemistry-and-pharmacology-for-its-commercial-utilization-in-drug-industry
#8
REVIEW
Biswanath Dinda, Anthony M Kyriakopoulos, Subhajit Dinda, Vassilis Zoumpourlis, Nikolaos S Thomaidis, Aristea Velegraki, Charlambos Markopoulos, Manikarna Dinda
ETHNOPHARMACOLOGICAL RELEVANCE: Cornus mas L. (cornelian cherry) fruits have been used for centuries as traditional cuisine and folk medicine in various countries of Europe and Asia. In folk medicines, the fruits and other parts of the plant have been used for prevention and treatment of a wide range of diseases such as diabetes, diarrhea, gastrointestinal disorders, fevers, rheumatic pain, skin and urinary tract infections, kidney and liver diseases, sunstroke, among others. This review provides a systematic and constructive overview of ethnomedicinal uses, chemical constituents and pharmacological activities of this plant as well as future research need for its commercial utilization as nutraceutical food supplement and medicine...
December 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27647940/proton-pump-inhibitors-in-ipf-beyond-mere-suppression-of-gastric-acidity
#9
REVIEW
Y Ghebre, G Raghu
Proton pump inhibitors (PPIs) are structurally composed of benzimidazole core; a pharmacologically common scaffold that makes up nearly one quarter of the hundred most selling drugs including anticancer, opioid, antihistaminic and antihelmintic drugs. In medicinal chemistry, benzimidazoles are coined as privileged scaffolds due to their ability to recognize and bind diverse biological targets. In this regard, PPIs have been linked to other extra-intestinal functions including direct modulation of airway epithelial, vascular endothelial and immune cells...
September 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/27623621/efficacy-and-safety-assessment-of-acupuncture-and-nimodipine-to-treat-mild-cognitive-impairment-after-cerebral-infarction-a-randomized-controlled-trial
#10
Shuhua Wang, Hongling Yang, Jie Zhang, Bin Zhang, Tao Liu, Lu Gan, Jiangang Zheng
BACKGROUND: Cerebral infarction frequently leads to mild cognitive impairment (MCI). Prompt management of MCI can prevent vascular dementia and improve patient outcome. This single center randomized controlled trial aims to investigate the efficacy and safety of acupuncture and nimodipine to treat post-cerebral infarction MCI. METHODS: A total of 126 Chinese patients with post-cerebral infarction MCI recruited from the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine between April 2013 and June 2014 were randomized at 1:1: 1 ratio into nimodipine alone (30 mg/time and 3 times daily), acupuncture alone (30 min/time, 6 times/week), and nimodipine + acupuncture groups...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27622956/the-effects-of-iontophoretic-injections-of-salvia-miltiorrhiza-on-the-maturation-of-the-arteriovenous-fistula-a-randomized-controlled-trial
#11
Wang Rongrong, Deng Li, Zhang Guangqing, Chen Xiaoyin, Bao Kun
Context • For patients undergoing hemodialysis, the native arteriovenous fistula (AVF) is the primary approach to vascular access (VA). VA failure is the main cause of morbidity and mortality in hemodialysis patients. It has been reported in recent studies that the primary failure rate can be as high as 50%. Objective • The study investigated the effects of iontophoretic administration of Salvia miltiorrhiza (SM) on the maturation of the AVF. Design • The study was a randomized, controlled trial. Setting • The study occurred in Guangdong Provincial Hospital of Traditional Chinese Medicine (Guangzhou, China)...
September 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/27610945/statin-withdrawal-in-people-with-dementia
#12
Bernadette McGuinness, Chris R Cardwell, Peter Passmore
BACKGROUND: There are approximately 24 million people worldwide with dementia; this is likely to increase to 81 million by 2040. Dementia is a progressive condition, and usually leads to death eight to ten years after first symptoms. End-of-life care should emphasise treatments that optimise quality of life and physicians should minimise unnecessary or non-beneficial interventions. Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors; they have become the cornerstone of pharmacotherapy for the management of hypercholesterolaemia but their ability to provide benefit is unclear in the last weeks or months of life...
September 9, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27608514/clinical-evaluation-of-a-dressing-with-poly-absorbent-fibres-and-a-silver-matrix-for-managing-chronic-wounds-at-risk-of-infection-a-non-comparative-trial
#13
S Dalac, L Sigal, A Addala, M Chahim, C Faivre-Carrere, Z Lemdjadi, S Bohbot
OBJECTIVE: To assess the efficacy, safety and acceptability of a new silver poly absorbent dressing (UrgoCleanAg) in the local management of exudative chronic wounds at risk of infection, with inflammatory signs suggesting heavy bacterial load. METHOD: This prospective, multicentre, non-comparative clinical trial was conducted in French hospital wards (dermatology and vascular medicine) or specialised private-practice physicians. Patients were considered at high-risk of infection when presenting with at least three of five selected inflammatory clinical signs, suggesting a heavy bacterial load (pain between two dressing changes, erythema, oedema, malodorous wound and presence of a heavy exudate)...
September 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27585078/tissue-engineering-in-the-larynx-and-airway
#14
Stellan Hertegård
PURPOSE OF REVIEW: Tissue engineering is a rapidly expanding field in medicine and involves regeneration and restoration of many organs, including larynx and the airways. Currently, this is not included in routine practice; however, a number of clinical trials in humans are ongoing or starting. This review will cover publications during the past 2 years and the focus is on larynx and trachea. RECENT FINDINGS: Recent reports concern the development and investigations of cell therapies, including biological factors such as growth factors which promote healing of damage and increased vascular support of the tissue...
August 31, 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27583245/from-here-to-there-progenitor-cells-and-stem-cells-are-everywhere-in-lung-vascular-remodeling
#15
REVIEW
Rebecca L Heise, Patrick A Link, Laszlo Farkas
The field of stem cell biology, cell therapy, and regenerative medicine has expanded almost exponentially, in the last decade. Clinical trials are evaluating the potential therapeutic use of stem cells in many adult and pediatric lung diseases with vascular component, such as bronchopulmonary dysplasia (BPD), chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), or pulmonary arterial hypertension (PAH). Extensive research activity is exploring the lung resident and circulating progenitor cells and their contribution to vascular complications of chronic lung diseases, and researchers hope to use resident or circulating stem/progenitor cells to treat chronic lung diseases and their vascular complications...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27560168/evaluation-of-the-ppar-%C3%AE-agonist-pioglitazone-in-mild-asthma-a-double-blind-randomized-controlled-trial
#16
J R Anderson, K Mortimer, L Pang, K M Smith, H Bailey, D B Hodgson, D E Shaw, A J Knox, T W Harrison
BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a nuclear receptor that modulates inflammation in models of asthma. To determine whether pioglitazone improves measures of asthma control and airway inflammation, we performed a single-center randomized, double-blind, placebo-controlled, parallel-group trial. METHODS: Sixty-eight participants with mild asthma were randomized to 12 weeks pioglitazone (30 mg for 4 weeks, then 45 mg for 8 weeks) or placebo...
2016: PloS One
https://www.readbyqxmd.com/read/27547712/adipose-tissue-and-mesenchymal-stem-cells-state-of-the-art-and-lipogems%C3%A2-technology-development
#17
Carlo Tremolada, Valeria Colombo, Carlo Ventura
In the past few years, interest in adipose tissue as an ideal source of mesenchymal stem cells (MSCs) has increased. These cells are multipotent and may differentiate in vitro into several cellular lineages, such as adipocytes, chondrocytes, osteoblasts, and myoblasts. In addition, they secrete many bioactive molecules and thus are considered "mini-drugstores." MSCs are being used increasingly for many clinical applications, such as orthopedic, plastic, and reconstructive surgery. Adipose-derived MSCs are routinely obtained enzymatically from fat lipoaspirate as SVF and/or may undergo prolonged ex vivo expansion, with significant senescence and a decrease in multipotency, leading to unsatisfactory clinical results...
2016: Current Stem Cell Reports
https://www.readbyqxmd.com/read/27544623/regenerative-medicine-therapies-for-stress-urinary-incontinence
#18
J Koudy Williams, Ashley Dean, Gopal Badlani, Karl-Erik Andersson
PURPOSE: We summarize the current state of knowledge regarding cell therapy for stress urinary incontinence and introduce new approaches of using regenerative pharmacology as an adjunct or replacement for cell therapy. MATERIALS AND METHODS: We reviewed the literature by searching PubMed®, Ovid and Biological Abstracts. The period searched was 1975 to December 2015. The inclusion terms separately or in combination were stress urinary incontinence, cell therapy, chemokine, vascularization, innervation, secretome and/or animal models...
August 18, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27544500/endovascular-vs-medical-therapy-in-symptomatic-vertebral-artery-stenosis-a-meta-analysis
#19
Hongliang Feng, Yi Xie, Bin Mei, Yang Liu, Benlei Li, Changqing Yin, Tao Wang, Yumin Liu
This meta-analysis aims to compare percutaneous transluminal angioplasty (PTA) to medical treatment (MT) for symptomatic vertebral artery stenosis (SVAS) treatment. We searched PubMed, Springer, Google Scholar, Clinical Trials, Cochrane Central, Chinese National Knowledge Infrastructure, and China Biological Medicine databases. All relevant comparative trials were included. All summary estimates were calculated by random-effect models. Ten comparative trials involving 672 patients were identified. Within 30-day follow-up, there was no significant difference between PTA plus MT and MT alone in vascular death, any stroke, posterior circulation TIA, posterior circulation infarction, and ischemic stroke (all P > 0...
August 20, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27538952/effect-of-xinyue-capsules-on-patients-with-coronary-heart-disease-after-percutaneous-coronary-intervention-study-protocol-for-a-randomized-controlled-trial
#20
Ming Guo, Ming-Jie Zi, Rui-Xi Xi, Qiao-Ning Yang, Rui-Na Bai, Yi-Sheng Zhang, Yu-Hua Wang, Pei-Li Wang, Da-Zhuo Shi
BACKGROUND: The risk of cardiovascular events remains high in patients with coronary heart disease (CHD) after successful percutaneous coronary intervention (PCI). Panax quinquefolius saponin, a major component of Xinyue capsule, has been used to treat patients with CHD. The aim of this study is to evaluate the efficacy and safety of Xinyue capsules in patients with CHD after PCI. METHODS/DESIGN: This study is a multicenter, placebo-controlled, double-blind, randomized controlled clinical trial...
2016: Trials
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