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lifelong learning in neurology

Lay Khoon Too, Andrew J Mitchell, Iain S McGregor, Nicholas H Hunt
During pneumococcal meningitis, clearance of bacteria by recruited neutrophils is crucial for host protection. However, these innate immune mechanisms are often insufficient and treatment with antibiotics is necessary to prevent death. Despite this antibiotic treatment, approximately half of all survivors suffer lifelong neurological problems. There is growing evidence indicating the harmful effects of neutrophils on CNS integrity. Therefore, the present study investigated the roles of neutrophils in the acute inflammatory response and the resulting long-term neuropsychological effects in murine pneumococcal meningitis...
August 2016: Brain, Behavior, and Immunity
Scott L Parker, Matthew J McGirt, Anthony L Asher, Nathan R Selden
There has been no formal, standardized curriculum for neurosurgical resident education in quality improvement. There are at least 2 reasons to integrate a formalized quality improvement curriculum into resident education: (1) increased emphasis on the relative quality and value (cost-effectiveness) of health care provided by individual physicians, and (2) quality improvement principles empower broader lifelong learning. An integrated quality improvement curriculum should comprise specific goals and milestones at each level of residency training...
April 2015: Neurosurgery Clinics of North America
Diana A Veneri, Mary Gannotti
BACKGROUND: Physical therapy (PT) educators have been charged by the American Physical Therapy Association's Vision 2020 with the aim of developing critically reflective knowledge about teaching and learning using innovative teaching methods. Computer-assisted learning (CAL) affords the opportunity to supplement face-to-face teaching methods. The purpose of this study was to compare student performance and preferred instruction mode between a hybrid model using CAL modules and a traditional lecture-based model...
2014: Journal of Allied Health
Hee-Yong Kim
Docosahexaenoic acid (DHA, 22:6 n-3) is an omega-3 polyunsaturated fatty acid highly enriched in the brain and is recognized as an essential nutrient for proper development of brain function. Common brain injuries often cause lifelong neurological and cognitive impairments, especially in learning and memory. Optimizing the nutritional DHA status in neural tissues may allow significantly improved resilience for the central nervous system to injury and optimized recovery. This article discusses neuroprotective effects of DHA, which are potentially important for improving injury outcome, thus reducing the risk of lifelong neurological impairment associated with brain injury...
November 2014: Military Medicine
Marco T Medina
The World Federation of Neurology (WFN) lost an outstanding leader on November 22, 2013 with the death of Professor Theodore Leon Munsat ("Ted"), in Waltham, Massachusetts, USA. Professor Munsat was Emeritus professor of Neurology at Tufts University School of Medicine and served the WFN in several capacities as trustee, chairman of the WFN Education and research committees, chairman of the WFN ALS Research group and founding director of the WFN Seminars in Clinical Neurology. He was president of the American Academy of Neurology (AAN), 1989-1991, chairman of the Continuing Educational Committee of the AAN and founding director of AAN's premier continuing medical education journal Continuum: Lifelong Learning in Neurology...
April 15, 2014: Journal of the Neurological Sciences
L K Too, H J Ball, I S McGregor, N H Hunt
Pneumococcal meningitis, caused by Streptococcus pneumoniae infection, is a major form of lethal bacterial meningitis. Survivors are predisposed to developing lifelong disabling sequelae, including cognitive impairment, psychological problems and motor deficits. In our experimental model, ventricular inoculation of 10(5) colony-forming units of S. pneumoniae type 3 caused 90% of mice to develop life-threatening meningitis within 48 h. Antibiotic treatment with ceftriaxone 20 h post infection reduced the incidence of severe meningitis to <10%...
January 2014: Brain, Behavior, and Immunity
Stuart Lavery, Dima Abdo, Mara Kotrotsou, Geoff Trew, Michalis Konstantinidis, Dagan Wells
Phenylketonuria (PKU) is an autosomal recessive inherited metabolic disorder caused by a complete or near-complete deficiency of the liver enzyme phenylalanine hydroxylase (PAH), which converts the amino acid phenylalanine to tyrosine, leading to the increase of blood and tissue concentration of phenylalanine to toxic levels. PKU is not life threatening but is treated through lifelong dietary management. If untreated, it can lead to severe learning disability, brain function abnormalities, behavioural and neurological problems...
2013: JIMD Reports
Nathan R Selden, Zoher Ghogawala, Robert E Harbaugh, Zachary N Litvack, Matthew J McGirt, Anthony L Asher
Outcomes-directed approaches to quality improvement have been adopted by diverse industries and are increasingly the focus of government-mandated reforms to health care education and delivery. The authors identify and review current reform initiatives originating from agencies regulating and funding graduate medical education and health care delivery. These reforms use outcomes-based methodologies and incorporate principles of lifelong learning and patient centeredness. Important new initiatives include the Accreditation Council for Graduate Medical Education Milestones; the pending adoption by the American Board of Neurological Surgery of new requirements for Maintenance of Certification that are in part outcomes based; initiation by health care systems and consortia of public reporting of patient outcomes data; institution by the Centers for Medicare & Medicaid Services of requirements for comparative effectiveness research and the physician quality reporting system; and linking of health care reimbursement in part to patient outcomes data and quality measures...
January 2013: Neurosurgical Focus
Jason Sheehan, Robert M Starke, Nader Pouratian, Zachary Litvack
OBJECTIVE: The practice of neurosurgery requires fundamental knowledge base. Residency training programs and continuing medical education courses are designed to teach relevant neurosurgical principles. Nevertheless, knowledge gaps exist for neurosurgeons and may be different between cohorts of neurosurgeons. The Self-Assessment in Neurological Surgery (SANS) General Examination and Spine Examination are online educational tools for lifelong learning and maintenance of certification. This study examines the gaps in knowledge of spinal neurosurgeons and general neurosurgeons taking SANS...
November 2013: World Neurosurgery
Maria T Acosta, Carrie E Bearden, F Xavier Castellanos, Xavier F Castellanos, Laurie Cutting, Ype Elgersma, Gerard Gioia, David H Gutmann, Yong-Seok Lee, Eric Legius, Maximillian Muenke, Kathryn North, Luis F Parada, Nancy Ratner, Kim Hunter-Schaedle, Alcino J Silva
Learning disabilities and other cognitive disorders represent one of the most important unmet medical needs and a significant source of lifelong disability. To accelerate progress in this area, an international consortium of researchers and clinicians, the Learning Disabilities Network (LeaDNet), was established in 2006. Initially, LeaDNet focused on neurofibromatosis type 1 (NF1), a common single gene disorder with a frequency of 1:3,000. Although NF1 is best recognized as an inherited tumor predisposition syndrome, learning, cognitive, and neurobehavioral deficits account for significant morbidity in this condition and can have a profound impact on the quality of life of affected individuals...
September 2012: American Journal of Medical Genetics. Part A
Aaron E Miller
No abstract text is available yet for this article.
June 2012: Continuum: Lifelong Learning in Neurology
Yanyan Wang, Maoquan Li, Xueqing Xu, Min Song, Huansheng Tao, Yun Bai
SCOPE: Adult hippocampal neurogenesis is a lifelong feature of brain plasticity that appears to be critically involved in adult brain function and neurological disease. Recent studies suggest that (-)-epigallocatechin-3-gallate (EGCG), which is the main polyphenolic constituent of green tea, may be used for the prevention and treatment of various neurodegenerative diseases. We hypothesized that EGCG promotes adult neurogenesis, which may be beneficial to hippocampus-dependent learning and memory...
August 2012: Molecular Nutrition & Food Research
Monica Cerreto, Bisan Mehdawy, Daniela Ombrone, Robert Nisticò, Margherita Ruoppolo, Alessandro Usiello, Aurora Daniele, Lucio Pastore, Francesco Salvatore
Phenylketonuria (PKU) is one of the most common inborn errors of metabolism and is due to a deficit of phenylalanine hydroxylase, the enzyme that converts phenylalanine (Phe) into tyrosine (Tyr). The resultant hyperphenylalaninemia (HPA) leads to severe neurological impairment, whose pathogenesis has not been entirely elucidated. Treatment of PKU consists essentially in lifelong protein restriction and, in mild cases, in tetrahydrobiopterin supplementation. However, compliance to both strategies, particularly to the long-term diet, is low and therefore other therapies are desirable...
February 1, 2012: Current Gene Therapy
Robert Li Kitts, Joanna Christodoulou, Stuart Goldman
OBJECTIVE: Professional siloing within medical institutions has been identified as a problem in medical education, including resident training. The authors discuss how trainees from different disciplines can collaborate to address this problem. METHOD: A group of trainees from psychiatry, developmental medicine, neurology, and education came together to develop a community of practice (CoP) to promote interdisciplinary collaboration. RESULTS: A key outcome was the development of a seminar including speakers and attendees (N=20 to 35) from psychiatry, developmental medicine, neurology, and education...
2011: Academic Psychiatry
Rumani Singh, Dinesh Lakhanpal, Sushil Kumar, Sandeep Sharma, Hardeep Kataria, Manpreet Kaur, Gurcharan Kaur
Lifelong dietary restriction (DR) is known to have many potential beneficial effects on brain function as well as delaying the onset of neurological diseases. In the present investigation, the effect of late-onset short-term intermittent fasting dietary restriction (IF-DR) regimen was studied on motor coordination and cognitive ability of ageing male rats. These animals were further used to estimate protein carbonyl content and mitochondrial complex I-IV activity in different regions of brain and peripheral organs, and the degree of age-related impairment and reversion by late-onset short-term IF-DR was compared with their levels in 3-month-old young rats...
August 2012: Age (2005-)
Michael W Church, John W Hotra, Pamela A Holmes, Jennifer I Anumba, Desmond A Jackson, Brittany R Adams
BACKGROUND: Fetal alcohol syndrome (FAS) is a leading cause of neurodevelopmental impairments (NDIs) in developed countries. Sensory deficits can play a major role in NDI, yet few studies have investigated the effects of prenatal alcohol exposure on sensory function. In addition, there is a paucity of information on the lifelong effects of prenatal alcohol exposure. Thus, we sought to investigate the effects of prenatal alcohol exposure on auditory function across the life span in an animal model...
January 2012: Alcoholism, Clinical and Experimental Research
Samuel Greggio, Simone de Paula, Iuri M de Oliveira, Cristiano Trindade, Renato M Rosa, João A P Henriques, Jaderson C DaCosta
Hypoxia-ischemia (HI) is a common cause of neonatal brain damage with lifelong morbidities in which current therapies are limited. In this study, we investigated the effect of neuropeptide NAP (NAPVSIPQ) on early cerebral oxidative stress, long-term neurological function and brain injury after neonatal HI. Seven-day-old rat pups were subjected to an HI model by applying a unilateral carotid artery occlusion and systemic hypoxia. The animals were randomly assigned to groups receiving an intraperitoneal injection of NAP (3 μg/g) or vehicle immediately (0 h) and 24 h after HI...
October 2011: Neurobiology of Disease
Etienne de Villers-Sidani, Michael M Merzenich
The rodent auditory cortex has provided a particularly useful model for studying cortical plasticity phenomenology and mechanisms, both in infant and in adult animal models. Much of our initial understanding of the neurological processes underlying learning-induced changes in the cortex stems from the early exploitation of this model. More recent studies have provided a rich and elaborate demonstration of the "rules" governing representational plasticity induced during the critical period (CP) and in the longer post-CP "adult" plasticity epoch...
2011: Progress in Brain Research
Richard S Isaacson, Joseph E Safdieh, Christopher N Ochner
BACKGROUND: Continuum: Lifelong Learning in Neurology® is a well-regarded and widely used continuing medical education tool published by the American Academy of Neurology. The objective of this study was to test the effectiveness of a modified version of the Dementia module of the Continuum curriculum, adapted for medical students rotating on their neurology clerkship, in increasing medical knowledge of dementia. METHODS: A multisite longitudinal randomized controlled design was used...
January 11, 2011: Neurology
Michael H Ebert, Larry Faulkner, Dorothy E Stubbe, Daniel K Winstead
The American Board of Medical Specialties (ABMS) developed 6 core competencies for physicians of all specialties and a maintenance of certification (MOC) program for board-certified physicians. The MOC program incorporates the 6 competencies into 4 component areas: professional standing, self-assessment and lifelong learning, cognitive expertise, and performance in practice. These 4 components are designed to promote a cycle of lifelong learning, self-assessment and peer review, and incorporation of best practices in order to improve the quality of health care in clinical practice...
October 2009: Journal of Clinical Psychiatry
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