keyword
MENU ▼
Read by QxMD icon Read
search

Ldh AND Cancer

keyword
https://www.readbyqxmd.com/read/29226652/a-pooled-analysis-of-the-clinical-utilities-of-long-non-coding-rna-based-molecular-signature-for-diffuse-large-b-cell-lymphoma
#1
Pei Xu, Xiaoli Chen, Panke Su
BACKGROUND: Long non-coding RNAs (lncRNAs) have been highlighted as promising biomarkers for several types of malignancies. The current meta-analysis sought to investigate the clinical value of lncRNA-based molecular signatures as biomarkers for diagnosis, subtype classification, and prognosis in diffuse large B cell lymphoma (DLBCL). METHODS: A systematic search of the online databases was carried out and data were retrieved by pairs of independent reviewers. Effect sizes of the diagnostic parameters were combined using a quantitative meta-analysis...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29224003/human-leukocyte-antigen-g-inhibits-the-anti-tumor-effect-of-natural-killer-cells-via-immunoglobulin-like-transcript-2-in-gastric-cancer
#2
Rui Wan, Zi-Wei Wang, Hui Li, Xu-Dong Peng, Guang-Yi Liu, Jun-Ming Ou, An-Qi Cheng
BACKGROUND/AIMS: Human leukocyte antigen-G (HLA-G) plays an important role in inhibiting natural killer (NK) cell function and promoting immune escape. However, the specific mechanism of HLA-G on NK in gastric cancer (GC) remains not well understood. This study investigated the expression of HLA-G in GC and the role of HLA-G-effected NK cells in GC progression. METHODS: HLA-G expression in GC tissues obtained from 49 patients with GC was analyzed by immunohistochemistry and western blot...
December 7, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29215037/pre-treatment-inflammatory-indexes-as-predictors-of-survival-and-cetuximab-efficacy-in-metastatic-colorectal-cancer-patients-with-wild-type-ras
#3
Jing Yang, Xinli Guo, Manni Wang, Xuelei Ma, Xiaoyang Ye, Panpan Lin
This study aims at evaluating the prognostic significance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation indexes (SII) in metastatic colorectal cancer (mCRC) patients treated with cetuximab. Ninety-five patients receiving cetuximab for mCRC were categorized into the high or low NLR, PLR, LMR, and SII groups based on their median index values. Univariate and multivariate survival analysis were performed to identify the indexes' correlation with progression-free survival (PFS) and overall survival (OS)...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208883/tumor-lysis-syndrome-and-hyperleukocytosis-in-childhood-acute-lymphoblastic-leukemia-in-a-tertiary-care-hospital
#4
R Tasmeen, A Islam, S T Alam, M Begum
Acute lymphoblastic leukemia is the most common (77%) childhood leukemia and also the most common neoplastic disease in children. Acute lymphoblastic leukemia initially present with hyperleukocytosis (WBC count more than 50,000/mm³) in twenty percent cases. These children are particularly at risk of development of tumor lysis syndrome (TLS). Tumor lysis syndrome is a metabolic disorder consists of hyperuricaemia, hyperkalemia, hyperphosphataemia, hypocalcaemia with or without renal insufficiency. It is the most common disease related emergency encountered by physicians caring for cancer of children and adult...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29199484/symmetric-molecules-with-1-4-triazole-moieties-as-potent-inhibitors-of-tumour-associated-lactate-dehydrogenase-a
#5
Abdul-Malek S Altamimi, Ahmed M Alafeefy, Agnese Balode, Igor Vozny, Aleksandrs Pustenko, Mohey Eldin El Shikh, Fatmah A S Alasmary, Sherif A Abdel-Gawad, Raivis Žalubovskis
A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-substituted triazoles as a side bridge was synthesised. The new compounds were investigated as lactate dehydro-genase (LDH, EC 1.1.1.27) inhibitors. The cancer associated LDHA isoform was inhibited with IC50 = 117-174 µM. Seven compounds exhibited better LDHA inhibition (IC50 117-136 µM) compared to known LDH inhibitor - galloflavin (IC50 157 µM).
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29197366/characteristics-and-outcome-in-patients-with-non-specific-symptoms-and-signs-of-cancer-referred-to-a-fast-track-cancer-patient-pathway-a-retrospective-cohort-study
#6
Sara Falk Jørgensen, Pernille Ravn, Søren Thorsen, Signe Westring Worm
BACKGROUND: In 2012 a new cancer patient pathway for patients with non-specific symptoms and signs of cancer (NSSC-CPP) was introduced in Denmark. Limited information is available about the patients referred to the NSSC-CPP and the investigational course. The aim was to describe the population and the investigational course, estimate the prevalence of cancer and one-year mortality, and identify factors associated with a subsequent cancer diagnosis in patients referred to the NSSC-CPP...
December 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29185401/improvement-in-therapeutic-ability-of-wharton-s-jelly-derived-mesenchymal-stem-cells-with-vitamin-e-in-breast-cancer
#7
Nadia Wajid, Muhammad Azam, Seemab Khalid, Fatima Ali, Aamer Qazi, M H Qazi
OBJECTIVE: To assess the role of Vitamin E to improve the survival of Wharton's jelly derived mesenchymal stem cells (WJMSCs) in breast cancer conditions. STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: Centre for Research in Molecular Medicine, University of Lahore, from November 2016 to March 2017. METHODOLOGY: WJMSCs were obtained from umbilical cord tissue with enzyme digestion method. Isolated cells were characterized for CD90 and CD45 by immunocytochemistry...
December 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29183726/gsdme-mediates-caspase-3-dependent-pyroptosis-in-gastric-cancer
#8
Yubin Wang, Bo Yin, Dinuo Li, Guijun Wang, Xiangdong Han, Xuejun Sun
Gastric cancer is a malignancy that starts from the cells in the stomach with relatively low overall survival rate. Chemotherapy following resection surgery has been recommended as a curative strategy for gastric cancer. However, the mechanism of the chemotherapy drugs on gastric cancer is not completely understood. Pyroptosis is a form of programmed cell death and plays critical role in immunity. The role of pyroptosis on cancer cells is less known. In this study, we treated SGC-7901 and MKN-45 with 5-FU and found that the cell viability was significantly decreased...
November 25, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29183371/cytotoxic-activity-of-nn-32-toxin-from-indian-spectacled-cobra-venom-on-human-breast-cancer-cell-lines
#9
Saurabh S Attarde, Sangeeta V Pandit
BACKGROUND: Breast cancer is the most common cancer which causes significant morbidity and mortality among women worldwide. Lack of medical facilities for early detection, therapeutic strategies for treatment and side effects due to pharmacological compounds have encompassed the need for new therapies mostly from natural sources. A lot of components have been identified from different snake venoms as therapeutic agents. A group of polypeptides (60-70 amino acid residues) called cytotoxins or cardiotoxins present in an elapid family of snakes have a wide variety of pharmaceutical actions and have the tendency to damage a wide variety of cells including cancerous cells...
November 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29181271/radium-223-in-metastatic-hormone-sensitive-high-grade-prostate-cancer-initial-experience
#10
García-Pérez Francisco Osvaldo, Medina-Ornelas Sevastián Salvador, Santana-Ríos Zael, Sobrevilla-Moreno Nora
Our study evaluates the feasibility of compassionate exemption of Radium-223 (223Ra) treatment in metastatic hormone-sensitive high-grade prostate cancer (mHSHGPC) patients with concomitant androgen deprivation-therapy (ADT). Seven patients with mHSHGPC, were treated with six cycles of 223Ra plus ADT. All patients had undergone to 18F-NaF-PET/CT. A qualitative analyses of the 18F-NaF-PET/CT was performed in conjunction with Alkaline Phosphatase (ALP), Lactate-dehydrogenase (LDH) and Prostatic-Specific Antigen (PSA) values...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29178148/confined-synthesis-of-carbon-nitride-in-a-layered-host-matrix-with-unprecedented-solid-state-quantum-yield-and-stability
#11
Wendi Liu, Simin Xu, Shanyue Guan, Ruizheng Liang, Min Wei, David G Evans, Xue Duan
Fluorescent carbon nanomaterials have drawn tremendous attention for their intriguing optical performances, but their employment in solid-state luminescent devices is rather limited as a result of aggregation-induced photoluminescence quenching. Herein, ultrathin carbon nitride (CN) is synthesized within the 2D confined region of layered double hydroxide (LDH) via triggering the interlayer condensation reaction of citric acid and urea. The resulting CN/LDH phosphor emits strong cyan light under UV-light irradiation with an absolute solid-state quantum yield (SSQY) of 95...
November 27, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29176547/protective-role-of-tnip2-in-myocardial-injury-induced-by-acute-pancreatitis-and-its-mechanism
#12
Hualei Xie, Maoyong Yang, Bo Zhang, Min Liu, Shumei Han
BACKGROUND Aberrant regulation of nuclear factor-κB (NF-κB) and the signaling pathways that regulate its activity have been found to be involved in various pathologies, particularly cancers, as well as inflammatory and autoimmune diseases. Acute pancreatitis (AP) is a complex pathological process, depending on autodigestion caused by premature activation of zymogens. This study aimed to investigate the effect of high expression of TNIP2 gene on AP and AP-induced myocardial injury. MATERIAL AND METHODS To investigate the effect of TNIP2 on AP and AP-induced myocardial injury, we established an AP cell model and rat model...
November 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29174853/inonotus-obliquus-extract-induces-apoptosis-in-the-human-colorectal-carcinoma-s-hct-116-cell-line
#13
Cheng-Chih Tsai, Yu-Sheng Li, Pei-Pei Lin
Because of irregular dietary habits and lifestyle in Taiwan, the incidence and mortality rate of colorectal cancer have been increasing rapidly these years. This study investigated the inhibitory activity against the proliferation of human colorectal cancer HCT-116 cells by Inonotus obliquus extracts obtained from submerged fermentation. Cell viability was measured by the reduction of MTT and cell membrane integrity was determined by lactic dehydrogenase (LDH) release. The mRNA expression of proapoptosis and antiapoptosis mediators was assayed by real-time PCR, and the levels of p53 and NF-κB p65 were assessed using Western blot analysis...
November 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29165057/pulmonary-toxicity-and-global-gene-expression-changes-in-response-to-sub-chronic-inhalation-exposure-to-crystalline-silica-in-rats
#14
Christina Umbright, Rajendran Sellamuthu, Jenny R Roberts, Shih-Houng Young, Diana Richardson, Diane Schwegler-Berry, Walter McKinney, Bean Chen, Ja Kook Gu, Michael Kashon, Pius Joseph
Exposure to crystalline silica results in serious adverse health effects, most notably, silicosis. An understanding of the mechanism(s) underlying silica-induced pulmonary toxicity is critical for the intervention and/or prevention of its adverse health effects. Rats were exposed by inhalation to crystalline silica at a concentration of 15 mg/m(3), 6 hr/day, 5 days/week for 3, 6 or 12 weeks. Pulmonary toxicity and global gene expression profiles were determined in lungs at the end of each exposure period...
2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29151289/-prognostic-value-of-18-f-fluorodeoxyglucose-fdg-positron-emission-tomography-computed-tomography-pet-ct-in-extensive-stage-small-cell-lung-cancer
#15
C Y Ding, Z Guo, Y Y Li, T R Li
Objective: To investigated the prognostic value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) in extensive-stage small cell lung cancer (ES -SCLC). Methods: Fifty-five patients with ES-SCLC who underwent pretreatment (18)F-FDG PET-CT were retrospectively recruited in this study. The correlations of maximum standardized uptake value (SUVmax) of primary lesion, metabolic tumor volume (MTV) of primary lesion (MTVp), total lesion glycolysis (TLG) of primary lesion (TLGp), the highest SUVmax of all lesions, the sum of metabolic volume (MTV sum), the sum of total lesions glycolysis (TLGsum) and clinical factors were analyzed...
November 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29149434/enhancement-of-therapeutic-dna-vaccine-potency-by-melatonin-through-inhibiting-vegf-expression-and-induction-of-antitumor-immunity-mediated-by-cd8-t-cells
#16
Sanaz Baghban Rahimi, Alireza Mohebbi, Gelareh Vakilzadeh, Peyvand Biglari, Soodeh Razeghi Jahromi, Seyed Reza Mohebi, Sadegh Shirian, Ali Gorji, Amir Ghaemi
To be effective, therapeutic cancer vaccines should stimulate both an effective cell-mediated and a robust cytotoxic CD8+ T-cell response against human papillomavirus (HPV)-infected cells to treat the pre-existing tumors and prevent potential future tumors. In this study, the therapeutic experiments were designed in order to evaluate antitumor effect against the syngeneic TC-1 tumor model. The anti-tumor efficacy of a HPV-16 E7 DNA vaccine adjuvanted with melatonin (MLT) was evaluated in a C57BL/6 mouse tumor model by measuring tumor growth post vaccination and the survival rate of tumor-bearing mice, analyzing the specific lymphocyte proliferation responses in control and vaccinated mice by MTT assay...
November 17, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29148861/a-new-approach-for-determining-short-term-objective-prognostic-predictive-methods-for-terminal-cancer-patients-based-on-the-change-point-of-laboratory-test-values
#17
Kazuyuki Niki, Yoshiaki Okamoto, Yoshitaka Tabata, Mamiko Tsugane, Taizo Murata, Masao Mizuki, Yasushi Matsumura, Tatsuya Takagi, Etsuko Uejima
BACKGROUND: In terminal phase cancer, predicting a prognosis precisely plays an important role for patients and their families to live meaningful lives. However, there are no established short-term, objective prognostic predictive methods. OBJECTIVE: To develop simple, short-term, objective prognostic predictive methods through detecting a change point for laboratory test values. DESIGN: A retrospective chart review. SETTING/SUBJECTS: Subjects were cancer patients aged ≥16 years and discharged dead from Osaka University Hospital in 2008...
November 17, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29147654/susceptibility-of-in-vitro-melanoma-skin-cancer-to-photoactivated-hypericin-versus-aluminium-iii-phthalocyanine-chloride-tetrasulphonate
#18
I M Ndhundhuma, H Abrahamse
The sensitivity of human melanoma cells to photoactivated Hypericin (Hyp) compared to aluminium(III) phthalocyanine chloride tetrasulphonate (AlPcS4Cl) is reported in this study. Melanoma cells (A375 cell line) were treated with various concentrations of Hyp or AlPcS4Cl alone, for 1, 4, and 24 hrs; varying doses of laser irradiation alone (594 or 682 nm); or optimal concentrations of PSs combined with laser irradiation. Changes in cell morphology, viability, membrane integrity, and proliferation after treatment of cells were determined using inverted microscopy, Trypan blue cell exclusion, Lactate Dehydrogenase (LDH) membrane integrity, and adenosine triphosphate (ATP) cell proliferation assay, respectively...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29145241/the-prognostic-value-of-the-serum-neuron-specific-enolase-and-lactate-dehydrogenase-in-small-cell-lung-cancer-patients-receiving-first-line-platinum-based-chemotherapy
#19
Xiaofan Liu, Weiming Zhang, Wen Yin, Yang Xiao, Changzhi Zhou, Yi Hu, Shuang Geng
The aim of this study was to investigate the associations of serum levels of neuron-specific enolase (NSE), pro-gastrin releasing peptide (ProGRP), and lactate dehydrogenase (LDH) with clinical response and survival in small cell lung cancer (SCLC) patients receiving first-line platinum-based chemotherapy.One hundred thirty-six patients with SCLC were recruited in this study. All the patients received first-line platinum-based chemotherapy. Clinical efficacy was assessed according to Response Evaluation Criteria in Solid Tumors v1...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29138850/role-of-mitochondrial-function-in-the-invasiveness-of-human-colon-cancer-cells
#20
Chen-Sung Lin, Li-Tzu Liu, Liang-Hung Ou, Siao-Cian Pan, Chia-I Lin, Yau-Huei Wei
We investigated the role of mitochondrial function in the invasiveness of human colorectal cancer (CRC) cell lines, using paired primary SW480 and metastatic SW620 cells, and appraised the clinical relevance of the alteration of mtDNA copy number in 33 pairs of CRC specimens after surgical resection. Suppression of mitochondrial function was achieved by the exposure of cells to oligomycin A (OA) or by knockdown of mitochondrial transcriptional factor A (TFAM) to evaluate their effects on energy metabolism, reactive oxygen species, protein expression levels of epithelial-mesenchymal transition (EMT) markers and invasive activity of CRC cells...
November 9, 2017: Oncology Reports
keyword
keyword
107582
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"