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https://www.readbyqxmd.com/read/27890637/antiplasmodial-activity-of-heinsia-crinita-rubiaceae-and-identification-of-new-iridoids
#1
P Tshisekedi Tshibangu, P Mutwale Kapepula, M J Kabongo Kapinga, A Tujibikila Mukuta, Dibungi T Kalenda, Alembert T Tchinda, Ange A Mouithys-Mickalad, O Jansen, E Cieckiewicz, M Tits, L Angenot, M Frédérich
ETHNOPHARMACOLOGICAL RELEVANCE: Heinsia crinita is used in traditional medicine for the treatment of febrile illness and erectile dysfunction. Its stem bark powder is found in some peripheral markets in the Democratic Republic of the Congo (DRC) as a remedy against malaria. Investigations were conducted on crude extracts of leaves, fruits and stem barks in view to validate their use and to determine which plant part possesses the best antiplasmodial properties. MATERIALS AND METHODS: Different plant parts were extracted with methanol, ethanol and dichloromethane...
November 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27877227/incidence-and-predictors-of-bone-metastases-bm-and-skeletal-related-events-sres-in-small-cell-lung-cancer-sclc-a-swiss-patient-cohort
#2
Katrin Conen, Raphael Hagmann, Viviane Hess, Alfred Zippelius, Sacha I Rothschild
Objectives: Bone metastases (BM) and skeletal-related events (SREs) are frequent complications in patients with lung cancer. Whereas in non-small-cell lung cancer (NSCLC) incidence, prognostic impact, and risk factors are well established, there is only little knowledge in patients with small cell lung cancer (SCLC). We retrospectively evaluated the incidence of BM, SRE and their treatment in a SCLC patient cohort treated at our hospital. We further assessed the role of Lactate Dehydrogenase (LDH), a possible predictor of BM development in SCLC patients...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27864220/estimating-12-weeks-death-probability-in-patients-with-refractory-metastatic-colorectal-cancer-the-colon-life-nomogram
#3
F Pietrantonio, R Miceli, L Rimassa, S Lonardi, G Aprile, A Mennitto, F Marmorino, S Bozzarelli, L Antonuzzo, E Tamburini, F Morano, D Rossini, F Battaglin, M Baretti, R Berenato, V Formica, S Mosconi, F Petrelli, M Ghidini, F Loupakis, D Spada, S Cinieri, G Beretta, A Falcone, F de Braud, C Cremolini
BACKGROUND: Regorafenib and TAS-102 have recently demonstrated statistically significant survival gains in patients with refractory metastatic colorectal cancer (mCRC). Life expectancy ≥12 weeks was an inclusion criterion in registrative trials, and the identification of proper clinical selection tools for the daily use of these drugs in heavily pre-treated patients is needed to improve the cost-benefit ratio. We aimed at building a nomogram able to predict death probability within 12 weeks from the date of assessment of refractory mCRC...
November 17, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27858107/gemcitabine-dexamethasone-and-cisplatin-gdp-as-salvage-chemotherapy-for-patients-with-relapsed-or-refractory-peripheral-t-cell-lymphoma-not-otherwise-specified
#4
Fei Qi, Mei Dong, Xiaohui He, Yexiong Li, Weihu Wang, Peng Liu, Jianliang Yang, Lin Gui, Changgong Zhang, Sheng Yang, Shengyu Zhou, Yuankai Shi
Standard therapeutic options for patients with relapsed or refractory peripheral T cell lymphoma-not otherwise specified (PTCL-NOS) remain unclear. There are few large cohort studies specifically focused on gemcitabine-based chemotherapy for PTCL-NOS. We retrospectively reviewed patients with relapsed or refractory PTCL-NOS who received salvage GDP (gemcitabine, dexamethasone, and cisplatin) chemotherapy at the Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, China, from May 2008 to August 2014...
November 17, 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27846929/-ccafu-french-national-guidelines-2016-2018-on-testicular-germ-cell-tumors
#5
X Durand, A Fléchon, T Murez, L Rocher, P Camparo, N Morel-Journel, P-H Savoie, L Ferretti, P Sèbe, A Méjean
INTRODUCTION: The purpose of the oncologic comitee of the french association of urology was to establish guidelines proposed by the external genital organ group, for the diagnosis, treatment and follow-up of the germ cell tumours of the testis. MATERIAL AND METHODS: The multidisciplinary working group studied 2013 guidelines, exhaustively reviewed the literature, and evaluated references and their level of proof in order to attribute grades of recommandation. RESULTS: The initial workup of testicular cancer is based on clinical, laboratory (AFP, total hCG, LDH) and imaging assessment (scrotal ultrasound and chest, abdomen and pelvis computed tomography)...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27836789/evaluation-of-cytotoxicity-of-a-purified-venom-protein-from-naja-kaouthia-nkct1-using-gold-nanoparticles-for-targeted-delivery-to-cancer-cell
#6
Tanmoy Bhowmik, Partha Pratim Saha, Amrita Sarkar, Antony Gomes
In our earlier report, gold nanoparticle (GNP) and snake venom protein toxin NKCT1 were conjugated and primary characteristics were done. In this communication, further characteristics of GNP-NKCT1 were done with TGA, BET, Zeta potential, ICP-MS, FTIR, XPS, and in vitro release kinetics for its physicochemical, molecular nature and bonding. TGA and ICP-MS showed that the number of conjugation was 40 ± 5 to 90 ± 8 NKCT1 per gold nanoparticles. FTIR and XPS corresponding to (CO), (NH), (SS) reformulated the conjugation of GNP with NKCT1...
November 9, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27830100/scrotal-involvement-with-testicular-nonseminomatous-germ-cell-tumour
#7
C G O'Leary, J A Allen, F O'Brien, A Tuthill, D G Power
A 37-year-old male presented with a traumatic injury to the scrotal region necessitating emergency surgery. Evacuation of a haematoma and bilateral orchidectomy were performed. A left sided nonseminomatous germ cell tumour (NSGCT), predominantly yolk sac, was identified. Microscopic margins were positive for tumour. Initial tumour markers revealed an AFP of 22,854 ng/mL, HCG of <1 mIU/mL, and LDH of 463 IU/L. Eight weeks after surgery, AFP levels remained elevated at 11,646 ng/mL. Computed tomography (CT) scanning demonstrated left inguinal adenopathy, 1...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27829997/propofol-inhibits-growth-and-invasion-of-pancreatic-cancer-cells-through-regulation-of-the-mir-21-slug-signaling-pathway
#8
Zimin Liu, Jian Zhang, Guangchen Hong, Jinping Quan, Lin Zhang, Meiqin Yu
AIM: Propofol, an intravenous anesthetic agent, has been found to inhibit invasion and growth of pancreatic cancer cells in vitro. However, the mechanisms underlying these tumor-promoting phenotypes are not known. The microRNA miR-21 has been reported to be overexpressed in pancreatic cancer, and overexpression of miR-21 confers a poor prognosis to patients with pancreatic cancer. Further studies have identified the E-cadherin transcription repressor Slug as a direct target of miR-21...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27829418/hepatoprotective-potential-of-fagonia-olivieri-dc-against-acetaminophen-induced-toxicity-in-rat
#9
Umbreen Rashid, Muhammad Rashid Khan, Moniba Sajid
BACKGROUND: Fagonia olivieri (DC) being used for the treatment of diabetes, cancer, fever and claimed to be effective in many other stress related disorders. In this study we have evaluated the F. olivieri whole methanol extract and its derived fractions for various in vitro and in vivo antioxidant studies. METHODS: The crude methanol extract of the whole plant of F. olivieri (FOM) and its derived fractions; n-hexane (FOH), chloroform (FOC), ethyl acetate (FOE), n-butanol (FOB) and aqueous (FOA) were evaluated for the total phenolic and flavonoid content and in vitro antioxidant abilities...
November 9, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27827510/synthesis-of-natural-urolithin-m6-a-galloflavin-mimetic-as-a-potential-inhibitor-of-lactate-dehydrogenase-a
#10
Sebastiano Rupiani, Laura Guidotti, Marcella Manerba, Lorenza Di Ianni, Elisa Giacomini, Federico Falchi, Giuseppina Di Stefano, Marinella Roberti, Maurizio Recanatini
Glycolysis is the main route for energy production in tumors. LDH-A is a key enzyme of this process and its inhibition represents an attractive strategy to hamper cancer cell metabolism. Galloflavin is a reliable LDH-A inhibitor as previously identified by us; however, its poor physicochemical properties and chemical tractability render it unsuitable for further development. Therefore, a rational design was undertaken with the aim to reproduce the pharmacophore of galloflavin on simpler, potentially more soluble and synthetic accessible scaffolds...
November 9, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27815475/survival-after-palliative-radiotherapy-in-patients-with-breast-cancer-and-bone-only-metastases
#11
Carsten Nieder, Astrid Dalhaug, Adam Pawinski, Bård Mannsåker, Ellinor Haukland
BACKGROUND/AIM: Patients with bone-only metastases survive longer than patients with widespread visceral disease. We analyzed the prognostic impact of different baseline parameters, such as abnormal blood tests and receptor status in patients who received local radiotherapy, in addition to contemporary systemic treatment, according to national guidelines. PATIENTS AND METHODS: Retrospective uni- and multivariate analyses of 57 consecutive female patients treated in the time period 2007-2014 (median follow-up=29 months)...
November 2016: In Vivo
https://www.readbyqxmd.com/read/27813595/antioxidant-activity-anti-proliferative-activity-and-amino-acid-profiles-of-ethanolic-extracts-of-edible-mushrooms
#12
S Panthong, N Boonsathorn, S Chuchawankul
Biological activities of various mushrooms have recently been discovered, particularly, immunomodulatory and antitumor activities. Herein, three edible mushrooms, Auricularia auricula-judae (AA), Pleurotus abalonus (PA) and Pleurotus sajor-caju (PS) extracted using Soxhlet ethanol extraction were evaluated for their antioxidative, anti-proliferative effects on leukemia cells. Using the Folin-Ciocalteau method and Trolox equivalent antioxidant capacity assay, phenolics and antioxidant activity were found in all sample mushrooms...
October 17, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27810785/gallic-acid-reduces-cell-growth-by-induction-of-apoptosis-and-reduction-of-il-8-in-hepg2-cells
#13
Kelly Goulart Lima, Gabriele Catyana Krause, Aline Daniele Schuster, Anderson Velasque Catarina, Bruno Souza Basso, Fernanda Cristina De Mesquita, Leonardo Pedrazza, Elisa Simon Marczak, Bianca Andrade Martha, Fernanda Bordignon Nunes, Eduardo Cremonese Filippi Chiela, Natália Jaeger, Marcos Paulo Thomé, Gabriela Viegas Haute, Henrique Bregolin Dias, Márcio Vinícius Fagundes Donadio, Jarbas Rodrigues De Oliveira
Hepatocellular carcinoma is the most prevalent primary liver tumor and is among the top ten cancer that affect the world population. Its development is related, in most cases, to the existence of chronic liver injury, such as in cirrhosis. The knowledge about the correlation between chronic inflammation and cancer has driven new researches with anti-inflammatory agents that have potential for the development of antitumor drugs. Gallic acid is a phenolic acid found in many natural products and have shown anti-inflammatory, anti-tumor, anti-mutagenic and antioxidant actions...
October 28, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27806706/rice-callus-suspension-culture-inhibits-growth-of-cell-lines-of-multiple-cancer-types-and-induces-apoptosis-in-lung-cancer-cell-line
#14
Nafeesa Rahman, Surendar Reddy Dhadi, Aparna Deshpande, Wusirika Ramakrishna
BACKGROUND: Cancer is one of the leading cause of mortality. Even though efficient drugs are being produced to treat cancer, conventional medicines are costly and have adverse effects. As a result, alternative treatments are being tried due to their low cost and little or no adverse effects. Our previous study identified one such alternative in rice callus suspension culture (RCSC) which was more efficient than Taxol® and Etoposide, in reducing the viability of human colon and renal cancer cells in culture with minimal or no effect on a normal cell line...
November 2, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27803158/tigar-metabolically-reprograms-carcinoma-and-stromal-cells-in-breast-cancer
#15
Ying-Hui Ko, Marina Domingo-Vidal, Megan Roche, Zhao Lin, Diana Whitaker-Menezes, Erin Seifert, Claudia Capparelli, Madalina Tuluc, Ruth C Birbe, Patrick Tassone, Joseph M Curry, Aurea Navarro-Sabate, Anna Manzano, Ramon Bartrons, Jaime Caro, Ubaldo Martinez-Outschoorn
A subgroup of breast cancers has several metabolic compartments. The mechanisms by which metabolic compartmentalization develop in tumors are poorly characterized. TP53 Inducible Glycolysis and Apoptosis Regulator (TIGAR) is a bisphosphatase, which reduces glycolysis and is highly expressed in carcinoma cells in the majority of human breast cancers. Hence we set out to determine the effects of TIGAR expression on breast carcinoma and fibroblast glycolytic phenotype and tumor growth. The overexpression of this bisphosphatase in carcinoma cells induces expression of enzymes and transporters involved in the catabolism of lactate and glutamine...
November 1, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27802448/post-discharge-survival-outcomes-of-patients-with-advanced-cancer-from-the-university-of-texas-md-anderson-cancer-center-investigational-cancer-therapeutics-phase-i-trials-inpatient-unit
#16
Holly Kinahan, Abhishek Maiti, Kenneth Hess, Jennifer Dempsey, Laura Beatty, Sarah Baldwin, David S Hong, Aung Naing, Siqing Fu, Apostolia M Tsimberidou, Sarina Piha-Paul, Filip Janku, Daniel Karp, Suresh Reddy, Sriram Yennu, Daniel Epner, Eduardo Bruera, Funda Meric-Bernstam, Gerald Falchook, Vivek Subbiah
BACKGROUND: Patients with advanced cancer who progress on standard therapy are potential candidates for phase I clinical trials. Due to their aggressive disease and complex comorbid conditions, these patients often need inpatient admission. This study assessed the outcomes of such patients after they were discharged to hospice care. PATIENTS AND METHODS: We performed a retrospective analysis of patients with solid tumor malignancies who were discharged to hospice care from the inpatient service...
November 2, 2016: Oncology
https://www.readbyqxmd.com/read/27798877/bongkrekic-acid-as-a-warburg-effect-modulator-in-long-term-estradiol-deprived-mcf-7-breast-cancer-cells
#17
Shuso Takeda, Hiroyuki Okazaki, Taichi Kudo, Kazuhiro Kakizoe, Taichi Himeno, Kenji Matsumoto, Mitsuru Shindo, Hironori Aramaki
BACKGROUND/AIM: An in vitro cell model of long-term estrogen-deprived MCF-7 (LTED) cells has been utilized to analyze the re-growth mechanisms of breast cancers treated with blockers for estrogen receptor α (ERα) signaling. Bongkrekic acid (BKA) is a natural toxin isolated from coconut tempeh contaminated with the bacterium Burkholderia cocovenans. MATERIALS AND METHODS: LTED cells, MCF-7 cells and MDA-MB-231 cells were employed in the study. After treatment with BKA (chemically synthesized; purity: >98%), several biochemical analyses were carried out...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27790297/disease-characteristics-and-survival-outcomes-of-extragonadal-primary-germ-cell-tumour-in-two-canadian-tertiary-cancer-centres
#18
Jenny J Ko, Tehmina Asif, Haocheng Li, Nimira Alimohamed, Phuong Thao Nguyen, Daniel Y C Heng
INTRODUCTION: Extragonadal germ cell tumours (EGCTs) are a heterogeneous group with distinct natural history and responses to treatment modalities. We sought to evaluate characteristics and survival outcomes in men with EGCTs. METHODS: We performed a retrospective analysis on a consecutive list of men diagnosed with EGCT in two Albertan cancer centres between 1990 and 2013. Demographic characteristics and outcomes, stratified by primary site, were evaluated. RESULTS: Sixty-nine cases were identified...
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27784361/-expression-and-prognostic-significance-of-h3k27-trimethylation-protein-in-dlbcl
#19
Yu-Jie Deng, Gang Chen, Wei-Feng Zhu, Hong-Bing Rui, Hua-Lan Hong, Jun-Min Chen
OBJECTIVE: To investigate the expression and prognostic effect of H3K27 trimethylation protein (H3K27me3) in diffuse large B-cell lymphoma(DLBCL). METHODS: A total of 102 DLBCL patients from Fujian Provincial Cancer Hospital were enrolled in this study. No therapy had been given before specimen collection. Tissue microarray(TMA) technique and immunohistochemistry(IHC) method were used for H3K27me3 immunostaining. Clinicopathologic and suvival data were carefully collected...
October 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27764805/nivolumab-for-advanced-melanoma-pretreatment-prognostic-factors-and-early-outcome-markers-during-therapy
#20
Yoshio Nakamura, Shigehisa Kitano, Akira Takahashi, Arata Tsutsumida, Kenjiro Namikawa, Keiji Tanese, Takayuki Abe, Takeru Funakoshi, Noboru Yamamoto, Masayuki Amagai, Naoya Yamazaki
BACKGROUND: An anti-programmed cell death protein 1 monoclonal antibody, nivolumab, is one of the most effective drugs for advanced melanoma. Tumor cell-derived or immune cell-derived markers and clinical predictors such as serum lactate dehydrogenase (LDH) and cutaneous adverse events, have already been described as prognostic factors for advanced melanoma treated with nivolumab. We sought to identify further clinical predictors that can be determined in routine clinical practice. METHODS: We retrospectively analyzed clinical findings of 98 consecutive patients with unresectable stage III or IV melanoma treated with nivolumab, at the National Cancer Center Hospital or at Keio University Hospital, in Tokyo, Japan, between July 2014 and July 2016...
October 15, 2016: Oncotarget
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