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Ldh AND Cancer

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https://www.readbyqxmd.com/read/28647589/mannose-conjugated-layered-double-hydroxide-nanocomposite-for-targeted-sirna-delivery-to-enhanced-cancer-therapy
#1
Li Li, Run Zhang, Wenyi Gu, Zhi Ping Xu
Sheet-like layered double hydroxide nanoparticles (LDH NPs) have showed great potentials in biomedical applications such as nanocarriers for drug and gene delivery, biosensors and imaging agents. However, target delivery of drugs and genes using LDH NPs to the desired tumor sites is a major challenge in cancer therapy. The aim of this study is to develop a functional LDH-based nanocomposite for target delivery of siRNA to cancer cells. Mannose as a targeting moiety was firstly conjugated onto SiO2-coated LDH nanocomposite...
June 21, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28646261/hepatic-arterial-infusion-chemotherapy-for-extensive-liver-metastases-of-breast-cancer-efficacy-safety-and-prognostic-parameters
#2
Mitra Tewes, Michael Wilhelm Peis, Simon Bogner, Jens M Theysohn, Marcus Paul Reinboldt, Martin Schuler, Anja Welt
PURPOSE: Hepatic arterial infusion chemotherapy (HAIC) is an option for patients with liver-predominant metastatic breast cancer (LMBC), when no further systemic treatment is available. But systematic reports are limited. Here we conducted a retrospective analysis of LMBC patients treated at an expert center. METHODS: Individual patient data were retrieved from the clinical data base of the West German Cancer Center. Primary endpoints included hepatic response (RECIST), progression-free survival (PFS), overall survival (OS), and toxicity...
June 23, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28643510/characterization-of-the-saffron-derivative-crocetin-as-an-inhibitor-of-human-lactate-dehydrogenase-5-in-the-antiglycolytic-approach-against-cancer
#3
Carlotta Granchi, Serena Fortunato, Serena Meini, Flavio Rizzolio, Isabella Caligiuri, Tiziano Tuccinardi, Hyang Yeon Lee, Paul J Hergenrother, Filippo Minutolo
Inhibition of lactate dehydrogenase (LDH) represents an innovative approach to tackle cancer because this peculiar glycolytic metabolism is characteristic of most invasive tumor cells. An investigation into the biological properties of saffron extracts led to the discover of their LDH-inhibition properties. In particular, the most important saffron components, crocetin, was found to inhibit LDH (IC50 = 54.9 ± 4.7 µM). This carotenoid was independently produced by chemical synthesis, and its LDH-inhibition properties manifested via its antiproliferative activity against two glycolytic cancer cell lines (A549 and HeLa, IC50 = 114...
June 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28643047/trace-elements-in-pleural-effusion-correlates-with-smokers-with-lung-cancer
#4
Kang-Yun Lee, Po-Hao Feng, Hsiao-Chi Chuang, Sheng-Ming Wu, Wen-Te Liu, Kuan-Yuan Chen, Chien-Ying Liu, Shu-Chuan Ho
Smoking leads to the presence of various elements, including toxic metals and metalloids, in tissues and fluids, thus contributing to cancer risk. This study assessed the concentrations of 14 elements (Ag, Al, As, Co, Cr, Cu, Fe, Ni, Mn, Mo, Pb, Sn, V, and Zn) and biochemical parameters (glucose, lactate dehydrogenase, and total protein) in the pleural effusion (PE) of patients with lung cancer. The potential association of these parameters with smoking was assessed. Total of 48 patients with lung cancer (26 non-smokers and 22 smokers) received thoracocentesis for PE removal...
June 22, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28638455/the-prognostic-and-predictive-value-of-carbohydrate-antigen-19-9-in-metastatic-colorectal-cancer-patients-with-first-line-bevacizumab-containing-chemotherapy
#5
Chang Jiang, Shousheng Liu, Wenzhuo He, Bei Zhang, Liangping Xia
Objective: We had previously demonstrated that the carbohydrate antigen 19-9 (CA19-9), lactate dehydrogenase (LDH), neutrophil lymphocyte ratio (NLR) are prognostic factors for patients with metastatic colorectal cancer (mCRC). In this study, we try to analysis the association of these blood-based biomarkers with bevacizumab efficacy in the first line setting. Methods: A total of 284 eligible consecutive mCRC patients who received first-line chemotherapy with or without bevacizumab were studied from 2007 to 2014 at Sun Yat-Sen University Cancer Center...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28630385/low-dose-of-lenalidomide-enhances-nk-cell-activity-possible-implication-as-an-adjuvant
#6
Kiandokht Borhani, Taravat Bamdad, Tayebeh Hashempour
BACKGROUND: Lenalidomide, a synthetic immunomodulatory drug, has a wide range of features including anti-angiogenic and anti-proliferative properties. To date, researchers have shown that lenalidomide is capable of ameliorating the immune system factors and antitumor responses. Most researchers have reported that lenalidomide enhances the immune response in certain cancer patients through several pathways including the stimulation of Natural Killer cells; notwithstanding, it is still crucial to investigate the effect of lenalidomide on the activity of NK cell cytotoxicity both in vitro and in vivo...
June 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28624617/core-shell-iron-oxide-layered-double-hydroxide-high-electrochemical-sensing-performance-of-h2o2-biomarker-in-live-cancer-cells-with-plasma-therapeutics
#7
Muhammad Asif, Hongwei Liu, Ayesha Aziz, Haitao Wang, Zhengyun Wang, Muhammad Ajmal, Fei Xiao, Hongfang Liu
In this work, we develop a new type of multifunctional core-shell nanomaterial by controllable integration of CuAl layered double hydroxides (LDHs) over the surface of iron oxides (Fe3O4) nanospheres (NSs) to fabricate (Fe3O4@CuAl NSs) hybrid material with interior tunability of LDH phase and explore its practical application in ultrasensitive detection of emerging biomarker, i.e., H2O2 as cancer diagnostic probe. In addition, atmospheric pressure plasmas (APPs) have also been used as potential therapeutic approach for cancer treatment...
June 3, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28612337/microrna-371a-3p-as-informative-biomarker-for-the-follow-up-of-testicular-germ-cell-cancer-patients
#8
Ton van Agthoven, Wil M H Eijkenboom, Leendert H J Looijenga
PURPOSE: α-fetoprotein (AFP) and human chorionic gonadotropin subunit beta (B-HCG) are informative serum biomarkers for the primary diagnosis and follow-up of testicular germ cell cancer (TGCC) patients. About 20% of TGCC patients with a non-seminoma (NS) and about 80% with a seminoma (SE) are, however, negative for these biomarkers. Embryonic stem cell microRNAs (miRs) may serve as promising alternative serum biomarkers. Here we investigated a retrospective series of serum samples from selected TGCC patients who developed a relapse in time to test the possible additional value of the serum-based ampTSmiR test compared to the conventional serum-based protein biomarkers for follow-up...
June 13, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28605733/the-association-between-fever-and-prognosis-in-lung-cancer-patients-with-bone-metastases-receiving-zoledronic-acid
#9
Tomiko Sunaga, Kazushi Shimamoto, Shoko Nakamura, Noriko Takahashi, Mayumi Higashino, Tomomi Hozumi, Mitsuki Matsui, Akiko Nagatani, Fumio Kokubu, Mari Kogo, Tadanori Sasaki
Zoledronic acid is an established agent used in the management of metastatic bone disease. The administration of zoledronic acid improves overall survival (OS) of lung cancer patients with bone metastases receiving chemotherapy. However, it is currently unknown whether zoledronic acid-induced fever is associated with OS. The purpose of this study was to examine the association between zoledronic acid-induced fever and prognosis in lung cancer patients with bone metastases. We retrospectively analyzed 98 lung cancer patients with bone metastases who had received zoledronic acid...
June 13, 2017: Chemotherapy
https://www.readbyqxmd.com/read/28599387/antioxidant-and-antiproliferative-potentials-of-methanol-extract-of-xylopia-aethiopica-dunal-a-rich-in-pc-3-and-lncap-cells
#10
Oluwatosin Adekunle Adaramoye, Bettina Erguen, Bianca Nitzsche, Michael Höpfner, Klaus Jung, Anja Rabien
BACKGROUND: Our previous studies showed that fruit methanol extract from Xylopia aethiopica (MEXA) exhibited antiproliferative activity in human cervical cancer cells via the induction of apoptosis. The present study was designed to assess the antiproliferative, antiangiogenic and antioxidant effects of MEXA on prostate cancer (PCa) cells (PC-3 and LNCaP). METHODS: PC-3 and LNCaP cells were cultured and treated with MEXA (10, 50 and 100 μg/mL). The sodium 3'-[1-(phenylaminocarbonyl)-3,4-tetrazolium]-bis (4-methoxy-6-nitro) benzene sulfonic acid hydrate (XTT) and lactate dehydrogenase (LDH) assays were used to evaluate cell viability and cytotoxicity, respectively...
May 24, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28598398/right-vs-left-sided-metastatic-colorectal-cancer-differences-in-tumor-biology-and-bevacizumab-efficacy
#11
Paola Ulivi, Emanuela Scarpi, Elisa Chiadini, Giorgia Marisi, Martina Valgiusti, Laura Capelli, Andrea Casadei Gardini, Manlio Monti, Silvia Ruscelli, Giovanni Luca Frassineti, Daniele Calistri, Dino Amadori, Alessandro Passardi
There is evidence of a different response to treatment with regard to the primary tumor localization (right-sided or left-sided) in patients with metastatic colorectal cancer (mCRC). We analyzed the different outcomes and biomolecular characteristics in relation to tumor localization in 122 of the 370 patients with metastatic colorectal cancer enrolled onto the phase III prospective multicenter "Italian Trial in Advanced Colorectal Cancer (ITACa)", randomized to receive first-line chemotherapy (CT) or CT plus bevacizumab (CT + B)...
June 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28597151/outcomes-and-prognostic-factors-for-relapsed-or-refractory-lymphoma-patients-in-phase-i-clinical-trials
#12
Jean-Marie Michot, Lina Benajiba, Laura Faivre, Capucine Baldini, Lelia Haddag, Clement Bonnet, Christophe Massard, Frederic Bigot, Camille Bigenwald, Benjamin Verret, Zoé A P Thomas, Andrea Varga, Anas Gazzah, Antoine Hollebecque, David Ghez, Julien Lazarovici, Rastilav Balheda, Aurore Jeanson, Sophie Postel-Vinay, Alina Danu, Jean-Charles Soria, Xavier Paoletti, Vincent Ribrag
Background Although safety and prognostic factors for overall survival (OS) have been extensively studied in Phase I clinical trials on patients with solid tumours, data on lymphoma trials are scarce. Here, we investigated safety, outcomes and prognostic factors in relapsed or refractory lymphoma patients included in a series of Phase I trials. Method and patients All consecutive adult patients with recurrent/refractory lymphoma enrolled in 26 Phase I trials at a single cancer centre in France between January 2008 and June 2016 were retrospectively assessed...
June 9, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28595013/fibroblast-activation-protein-alpha-activated-tripeptide-bufadienolide-anti-tumor-prodrug-with-reduced-cardiotoxicity
#13
Li-Juan Deng, Long-Hai Wang, Cheng-Kang Peng, Yi-Bin Li, Mao-Hua Huang, Min-Feng Chen, Xue-Ping Lei, Ming Qi, Yun Cen, Wen-Cai Ye, Dong-Mei Zhang, Wei-Min Chen
Bufadienolides are the major pharmacologic constituents of traditional Chinese medicine Chan'su, which are frequently used clinically for cancer treatment in China. Motivated by reducing or avoiding the cardiac toxicity of bufadienolides, we have designed, synthesized and evaluated the fibroblast activation protein alpha (FAPα)-activated tripeptide arenobufagin prodrugs with the purpose of improving the safety of arenobufagin (a representative bufadienolide). Among these FAPα-activated prodrugs, 3f exhibited the best hydrolytic efficiency by recombinant human FAPα (rhFAPα), and are selectively activated in tumors...
June 8, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28589262/the-surgical-outcomes-of-lung-cancer-combined-with-interstitial-pneumonia-a-single-institution-report
#14
Daisuke Taniguchi, Naoya Yamasaki, Takuro Miyazaki, Tomoshi Tsuchiya, Keitaro Matsumoto, Go Hatachi, Tomoyuki Kakugawa, Noriho Sakamoto, Hiroshi Mukae, Takeshi Nagayasu
PURPOSE: Several studies have reported that an acute exacerbation (AE) of idiopathic interstitial pneumonia (IIP) can occur after lung resection in patients with non-small cell lung cancer (NSCLC); however, the perioperative management strategy is controversial. METHODS: The data of lung cancer patients at Nagasaki University Hospital from June 1994 to October 2013 were retrospectively reviewed. RESULTS: Among all 1701 NSCLC patients who underwent lung resection, 59 (3...
June 6, 2017: Surgery Today
https://www.readbyqxmd.com/read/28585312/manganese-based-layered-double-hydroxide-nanoparticles-as-a-t1-mri-contrast-agent-with-ultrasensitive-ph-response-and-high-relaxivity
#15
Bei Li, Zi Gu, Nyoman Kurniawan, Weiyu Chen, Zhi Ping Xu
Recently, Mn(II)-containing nanoparticles have been explored widely as an attractive alternative to Gd(III)-based T1 -weighted magnetic resonance imaging (MRI) contrast agents (CAs) for cancer diagnosis. However, as far as it is known, no Mn-based MRI CAs have been reported to sensitively respond to a very weakly acidic environment (pH 6.5-7.0, i.e., the pH range in a tumor microenvironment) with satisfactory imaging performance. Here, recently devised pH-ultrasensitive Mn-based layered double hydroxide (Mn-LDH) nanoparticles with superb longitudinal relaxivity (9...
June 6, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28582845/elevated-lactate-dehydrogenase-ldh-can-be-a-marker-of-immune-suppression-in-cancer-interplay-between-hematologic-and-solid-neoplastic-clones-and-their-microenvironments
#16
Jennifer Ding, Judith E Karp, Ashkan Emadi
Metabolism of neoplastic cells is shifted toward high glucose uptake and enhanced lactate production. Lactate dehydrogenase (LDH), which is comprised of two major subunits, LDH-A and LDH-B, reversibly catalyzes the conversion of pyruvate to lactate or lactate to pyruvate. LDH-A has a higher affinity for pyruvate and is a key enzyme in the glycolytic pathway. Elevated LDH is a negative prognostic biomarker not only because it is a key enzyme involved in cancer metabolism, but also because it allows neoplastic cells to suppress and evade the immune system by altering the tumor microenvironment...
May 19, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28577052/-analysis-of-therapy-relevant-receptors-in-bone-marrow-carcinosis-comparison-of-pathological-and-clinical-parameters
#17
G Massenkeil, C Gropp, H Kreipe, K Hussein
BACKGROUND: Bone marrow carcinosis is a sign of advanced tumor stage with nonspecific clinical and hematological symptoms. Diagnosis is based on bone marrow biopsy and histopathology, but biopsies are not part of the standard work-up in oncological diseases and data on the correlation between clinical presentation and pathological findings are sparse. MATERIAL AND METHODS: In a retrospective single-center study, data from 20 tumor patients with bone marrow carcinosis were analyzed...
June 2, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28574700/a-facile-way-of-modifying-layered-double-hydroxide-nanoparticles-with-targeting-ligand-conjugated-albumin-for-enhanced-delivery-to-brain-tumour-cells
#18
Huali Zuo, Weiyu Chen, Helen M Cooper, Zhi Ping Xu
Active targeting of nanoparticles (NPs) for cancer treatment has attracted increasing interest in the past decades. Various ligand modification strategies have been used to enhance the targeting of NPs to the tumor site. However, how to reproducibly fabricate diverse targeting NPs with narrowly changeable biophysiochemical properties remains as a major challenge. In this study, layered double hydroxide (LDH) NPs were modified as a target delivery system. Two brain tumor targeting ligands, i.e., angiopep-2 and rabies virus glycoprotein, were conjugated to the LDH NPs via an intermatrix protein moiety, bovine serum albumin (BSA), simultaneously endowing the LDHs with excellent colloidal stability and targeting capability...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28557065/lactate-dehydrogenase-predicts-combined-progression-free-survival-after-sequential-therapy-with-abiraterone-and-enzalutamide-for-patients-with-castration-resistant-prostate-cancer
#19
Keiichiro Mori, Takahiro Kimura, Hajime Onuma, Shoji Kimura, Toshihiro Yamamoto, Hiroshi Sasaki, Jun Miki, Kenta Miki, Shin Egawa
BACKGROUND: An array of clinical issues remains to be resolved for castration-resistant prostate cancer (CRPC), including the sequence of drug use and drug cross-resistance. At present, no clear guidelines are available for the optimal sequence of use of novel agents like androgen-receptor axis-targeted (ARAT) agents, particularly enzalutamide, and abiraterone. METHODS: This study retrospectively analyzed a total of 69 patients with CRPC treated with sequential therapy using enzalutamide followed by abiraterone or vice versa...
May 30, 2017: Prostate
https://www.readbyqxmd.com/read/28551766/axl-gas6-expression-can-predict-for-adverse-prognosis-in-non-small-cell-lung-cancer-with-brain-metastases
#20
Xiaoliang Wu, Wenjuan Ma, Qianghua Zhou, Haijuan Yan, Zuan-Fu Lim, Mayan Huang, Chuangzhong Deng, Xingsu Yu, Huifang Su, Satoshi Komo, Haixia Yang, Xinke Zhang, Sijin Wen, Zhenfeng Zhang, Patrick C Ma
PURPOSE: Patients with non-small cell lung cancer (NSCLC) brain metastases (BM) have poor clinical outcomes. We sought to determine if AXL-GAS6 expression can be used as independent prognostic biomarkers for NSCLC BM. METHODS: We retrospectively studied the medical records of 98 patients diagnosed with advanced metastatic NSCLC from December 2000 to June 2014. Out of a total of 98 patients with NSCLC metastases, 66 patients were identified to have brain metastases...
May 27, 2017: Journal of Cancer Research and Clinical Oncology
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