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Meloxicam

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https://www.readbyqxmd.com/read/29670468/analysis-of-drug-effects-on-primary-human-coronary-artery-endothelial-cells-activated-by-serum-amyloid-a
#1
K Lakota, D Hrušovar, M Ogrič, K Mrak-Poljšak, S Čučnik, M Tomšič, B Božič, P Žigon, S Sodin-Semrl
Background: RA patients have a higher incidence of cardiovascular diseases compared to the general population. Serum amyloid A (SAA) is an acute-phase protein, upregulated in sera of RA patients. Aim: To determine the effects of medications on SAA-stimulated human coronary artery endothelial cells (HCAEC). Methods: HCAEC were preincubated for 2 h with medications from sterile ampules (dexamethasone, methotrexate, certolizumab pegol, and etanercept), dissolved in medium (captopril) or DMSO (etoricoxib, rosiglitazone, meloxicam, fluvastatin, and diclofenac)...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29665554/inhibition-by-non-steroidal-anti-inflammatory-drugs-of-compound-action-potentials-in-frog-sciatic-nerve-fibers
#2
Rika Suzuki, Tsugumi Fujita, Kotaro Mizuta, Eiichi Kumamoto
AIMS: Although antinociception produced by non-steroidal anti-inflammatory drugs (NSAIDs) is partly attributed to nerve conduction inhibition, this has not been thoroughly examined yet. The aim of the present study was to reveal quantitatively how various types of NSAIDs affect compound action potentials (CAPs), a measure of nerve conduction. MAIN METHODS: CAPs were recorded from the frog sciatic nerve by using the air-gap method. KEY FINDINGS: Soaking the sciatic nerve with acetic acid-based NSAIDs (diclofenac and aceclofenac) reduced the peak amplitude of CAP in a concentration-dependent manner; their IC50 values were 0...
April 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29629863/early-experience-with-topical-meloxicam-and-lidocaine-combination-for-the-treatment-of-vulvodynia
#3
Rufina Kim, Kerri-Lynn Kelly, Merle Olsen, J Curtis Nickel
INTRODUCTION: We report our early clinical observations on the use of topical meloxicam and lidocaine gel for patients with vulvodynia. METHODS: This is an early experience in participants with a history of vulvodynia evaluated and treated at the Queen's University Pelvic and Bladder Pain Clinic. Combination meloxicam 0.3% and lidocaine 5% were provided to the participants and they were instructed to apply 5 cc to the vulvar area twice daily. Standardized assessment was conducted for each participant before the start of the topical therapy and again at one week included Interstitial Cystitis Symptom Index (ICSI), Interstitial Cystitis Problem Index (ICPI), and pain scoring (Likert) for vulvar pain, in addition to a subjective global assessment after a week of treatment...
April 6, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29628389/effects-of-buprenorphine-butorphanol-or-tramadol-premedication-on-anaesthetic-induction-with-alfaxalone-in-common-marmosets-callithrix-jacchus
#4
Jaco Bakker, Sandra Roubos, Edmond J Remarque, Saskia S Arndt, Peter W Kronen, Jan Am Langermans
OBJECTIVE: To investigate the clinical and physiological effects of intravenous (IV) alfaxalone alone or in combination with buprenorphine, butorphanol or tramadol premedication in marmosets. STUDY DESIGN: Prospective, randomized, blinded, crossover design. ANIMALS: Nine healthy marmosets (391 ± 48 g, 3.7 ± 2.2 years old). METHODS: Meloxicam 0.20 mg kg-1 subcutaneously, atropine 0.05 mg kg-1 intramuscularly (IM) and either buprenorphine 20 μg kg-1 IM (BUP-A), butorphanol 0...
February 5, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29619605/both-melatonin-and-meloxicam-improved-sleep-and-pain-in-females-with-primary-dysmenorrhea-results-from-a-double-blind-cross-over-intervention-pilot-study
#5
Farahnaz Keshavarzi, Fariba Mahmoudzadeh, Serge Brand, Dena Sadeghi Bahmani, Fariba Akbari, Habibolah Khazaie, Mohammad Rasoul Ghadami
Up to 25% of ovulating women suffer from primary dysmenorrhea, a condition associated with pain and transient-reduced quality of life, along with greater irritability and impaired sleep. In the present study, we asked whether and if so to what extent melatonin and meloxicam can improve subjective and objective sleep and reduce pain among women with primary dysmenorrhea (PD). To this end, we conducted a double-blind cross-over clinical trial lasting for three menstrual cycles. A total of 14 women (mean age M = 27...
April 4, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29605543/anti-candidal-activity-of-selected-analgesic-drugs-used-alone-and-in-combination-with-fluconazole-itraconazole-voriconazole-posaconazole-and-isavuconazole
#6
J Król, U Nawrot, M Bartoszewicz
BACKGROUND: The antifungal activity of some popular analgesic drugs was postulated by several authors. OBJECTIVES: The aim of this study was to verify the antifungal effectiveness of acetylsalicylic acid, ibuprofen, metamizole, meloxicam and paracetamol against triazole-susceptible and triazole-resistant Candida spp isolates. METHODS: The minimal inhibitory concentration as well as fractional inhibitory concentration of selected analgesics and triazole on eighteen Candida spp isolates were determined by the standard microdilution method according to EUCAST...
March 28, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29597330/investigation-of-absorption-routes-of-meloxicam-and-its-salt-form-from-intranasal-delivery-systems
#7
Csilla Bartos, Rita Ambrus, Anita Kovács, Róbert Gáspár, Anita Sztojkov-Ivanov, Árpád Márki, Tamás Janáky, Ferenc Tömösi, Gábor Kecskeméti, Piroska Szabó-Révész
The aim of this article was to study the trans-epithelial absorption to reach the blood and to target the brain by axonal transport using nasal formulations with nanonized meloxicam (nano MEL spray) and its salt form known as meloxicam potassium monohydrate (MELP spray). The physicochemical properties and the mucoadhesivity of nasal formulations were controlled. In vitro and in vivo studies were carried out. These forms were first investigated in "nose-to-brain" relation. It was found that the in vitro study and in vivo study did not show any significant correlation...
March 28, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29595359/feline-hyperaesthesia-syndrome-with-self-trauma-to-the-tail-retrospective-study-of-seven-cases-and-proposal-for-integrated-multidisciplinary-diagnostic-approach
#8
Pablo Amengual Batle, Clare Rusbridge, Tim Nuttall, Sarah Heath, Katia Marioni-Henry
Case series summary This was a retrospective study on the clinical features and response to treatment in seven cats with feline hyperaesthesia syndrome (FHS) and tail mutilation. FHS is a poorly understood disorder characterised by skin rippling over the dorsal lumbar area, episodes of jumping and running, excessive vocalisation, and tail chasing and self-trauma. The majority of the cats were young, with a median age of 1 year at the onset of clinical signs, male (n = 6) and with access to the outdoors (n = 5)...
March 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29588616/optimal-management-of-orthodontic-pain
#9
REVIEW
Francielle Topolski, Alexandre Moro, Gisele Maria Correr, Sasha Cristina Schimim
Pain is an undesirable side effect of orthodontic tooth movement, which causes many patients to give up orthodontic treatment or avoid it altogether. The aim of this study was to investigate, through an analysis of the scientific literature, the best method for managing orthodontic pain. The methodological aspects involved careful definition of keywords and diligent search in databases of scientific articles published in the English language, without any restriction of publication date. We recovered 1281 articles...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29568654/hepatotoxicity-of-nonsteroidal-anti-inflammatory-drugs-a-systematic-review-of-randomized-controlled-trials
#10
REVIEW
Pajaree Sriuttha, Buntitabhon Sirichanchuen, Unchalee Permsuwan
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used medication in several countries, including Thailand. NSAIDs have been associated with hepatic side effects; however, the frequency of these side effects is uncertain. Aim of the Review: To systematically review published literature on randomized, controlled trials that assessed the risk of clinically significant hepatotoxicity associated with NSAIDs. Methods: Searches of bibliographic databases EMBASE, PubMed, and the Cochrane Library were conducted up to July 30, 2016, to identify randomized controlled trials of ibuprofen, naproxen, diclofenac, piroxicam, meloxicam, mefenamic acid, indomethacin, celecoxib, and etoricoxib in adults with any disease that provide information on hepatotoxicity outcomes...
2018: International Journal of Hepatology
https://www.readbyqxmd.com/read/29567597/a-randomised-field-study-evaluating-the-effectiveness-of-buccal-meloxicam-and-topical-local-anaesthetic-formulations-administered-singly-or-in-combination-at-improving-welfare-of-female-merino-lambs-undergoing-surgical-mulesing-and-hot-knife-tail-docking
#11
Alison Holdhus Small, Danila Marini, Tim Dyall, David Paull, Caroline Lee
This study was a field-based behavioural assessment of the pain responses to surgical mulesing modulated by a buccal formulation of meloxicam (Buccalgesic) and a topical local anaesthetic wound dressing (Tri-Solfen). 20 lambs were randomly allocated to each of: 1) Placebo and sham handled (Sham); 2) Placebo and mulesing (Mules); 3) Buccalgesic and mulesing (Mules+B); 4) Tri-Solfen and mulesing (Mules+T); 5) Placebo, Tri-Solfen and mulesing (Mules+T+P); 6) Buccalgesic, Tri-Solfen and mulesing (Mules+T+B). Lamb behaviour was observed by scan sampling every 15 min for 6 h post mulesing then for 1...
March 8, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29566073/development-of-tizanidine-hcl-meloxicam-loaded-mucoadhesive-buccal-films-in-vitro-and-in-vivo-evaluation
#12
Muhammad Zaman, Muhammad Hanif, Zaib Ali Shaheryar
The purpose of the study was to develop Tizanidine HCl (TZN) and Meloxicam (MLX) loaded bilayer mucoadhesive films intended for buccal administration, aiming to enhance the bioavailability. Bilayer films were prepared by solvent evaporation technique selecting arabinoxylan (ARX) as a sustained release (SR) layer forming polymer and hydroxypropyl methylcellulose (HPMC) E-15 as an immediate release (IR) layer-forming polymer. Prepared films were subjected to in-vitro drug release, surface morphology, mechanical strength, compatibility of the ingredients, drug contents, ex-vivo mucoadhesion strength and drug permeation...
2018: PloS One
https://www.readbyqxmd.com/read/29554032/efficacy-and-safety-of-intravenous-meloxicam-in-subjects-with-moderate-to-severe-pain-following-bunionectomy-a-randomized-double-blind-placebo-controlled-trial
#13
Richard A Pollak, Ira J Gottlieb, Fardin Hakakian, John C Zimmerman, Stewart W McCallum, Randall J Mack, Rosemary Keller, Alex Freyer, Wei Du
OBJECTIVE: To evaluate the analgesic efficacy and safety of a novel intravenous (IV) formulation of meloxicam (30▒mg) in subjects with moderate-to-severe pain following a standardized, unilateral bunionectomy with first metatarsal osteotomy and internal fixation. METHODS: Subjects who met the criteria for moderate-to-severe postoperative pain were randomized to receive bolus injections of meloxicam IV 30▒mg (n=100) or placebo (n=101) administered once daily...
March 16, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29545755/exploration-of-the-anti-inflammatory-drug-space-through-network-pharmacology-applications-for-drug-repurposing
#14
Guillermo de Anda-Jáuregui, Kai Guo, Brett A McGregor, Junguk Hur
The quintessential biological response to disease is inflammation. It is a driver and an important element in a wide range of pathological states. Pharmacological management of inflammation is therefore central in the clinical setting. Anti-inflammatory drugs modulate specific molecules involved in the inflammatory response; these drugs are traditionally classified as steroidal and non-steroidal drugs. However, the effects of these drugs are rarely limited to their canonical targets, affecting other molecules and altering biological functions with system-wide effects that can lead to the emergence of secondary therapeutic applications or adverse drug reactions (ADRs)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29544974/development-and-validation-of-ultra-performance-liquid-chromatography-method-for-the-determination-of-meloxicam-and-its-impurities-in-active-pharmaceutical-ingredients
#15
K Louati, I Bargaoui, F Safta
The main objective was to develop a suitable and rapid ultra-performance liquid chromatography (UPLC) method for the quantitative determination of meloxicam and its impurities. Starting from data in literature, we calculated the new parameters to translate a high performance liquid chromatography method used for the analysis of meloxicam with its major degradation products to UPLC method, and then we switched on many trials to optimize and improve its analytical performance. Chromatographic separation was achieved on ACQUITY UPLC HSS-T3 (2...
March 12, 2018: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29539592/a-field-study-evaluation-of-buccal-meloxicam-and-topical-anaesthetic-at-improving-welfare-of-lambs-undergoing-surgical-mulesing-and-hot-knife-tail-docking
#16
Alison Holdhus Small, Danila Marini, Maxime le Floch, David Paull, Caroline Lee
Mulesing is a painful husbandry procedure commonly used to reduce the risk of breech strike in sheep. This study assessed the behavioural (over 6 h), cortisol, haptoglobin and haematology responses to surgical mulesing plus tail hot knife docking (mulesing); modulated by a buccal meloxicam formulation (Buccalgesic), a topical local anaesthetic wound dressing (Tri-Solfen) or both agents. 24 lambs were allocated to each of: 1) Placebo and sham handled (Sham); 2) Placebo and mulesing (Mules); 3) Buccalgesic and mulesing (Mules + B); 4) Tri-Solfen and mulesing (Mules + T); 5) Placebo, Tri-Solfen and mulesing (Mules + T + P); 6) Buccalgesic, Tri-Solfen and mulesing (Mules + T + B)...
February 28, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29506317/quantitative-determination-of-meloxicam-in-dog-plasma-by-high-performance-liquid-chromatography-tandem-mass-spectrometry-and-its-application-in-a-pharmacokinetic-study
#17
Yongzhi Tian, Xiao Wu, Mingjie Zhang, Longshan Zhao, Zhili Xiong, Feng Qin
A rapids, selective and sensitive high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed to determine meloxicam in beagle dog plasma. Sample pretreatment involved a one-step protein precipitation with methanol of 0.1 mL plasma. Analysis was performed on a Venusil ASB-C18 column with mobile phase consisting of methanol-water (containing 0.1% formic acid) (75:25, v/v). The detection was performed on a triple quadrupole tandem mass spectrometer by multiple reaction monitoring (MRM) mode via electrospray ionization (ESI) source...
March 5, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29506258/effect-of-a-single-dose-of-meloxicam-prior-to-band-or-knife-castration-in-1-week-old-beef-calves-i-acute-pain
#18
D M Meléndez, S Marti, E A Pajor, D Moya, D Gellatly, E D Janzen, K S Schwartzkopf-Genswein
In Western-Canada, approximately half of the calves produced are castrated before 1 wk of age. Therefore, it is important to identify effective analgesic drugs to mitigate pain associated with castration and consequently improve animal welfare. The aim of this study was to assess the efficacy of a single s.c. dose of meloxicam at mitigating pain associated with knife and band castration in 1 wk old calves. Seventy-two Angus crossbred bull calves (47.3 ± 6.70 kg of BW, 1 wk old) were used in a 3 × 2 factorial design where main factors included castration method-sham (CT), band (BA) or knife (KN) castration-and medication-lactate ringer (NM) or 0...
February 28, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29497329/evaluation-of-the-safety-and-efficacy-of-an-intravenous-nanocrystal-formulation-of-meloxicam-in-the-management-of-moderate-to-severe-pain-after-bunionectomy
#19
Ira J Gottlieb, Deborah R Tunick, Randall J Mack, Stewart W McCallum, Campbell P Howard, Alex Freyer, Wei Du
Objective: This randomized, double-blind, placebo-controlled study evaluated the safety and efficacy of an intravenous (IV) nanocrystal formulation of meloxicam in subjects with moderate-to-severe pain following a standardized unilateral bunionectomy. Methods: Fifty-nine subjects aged 18-72 years were randomized to receive doses of either 30 mg (n=20) or 60 mg (n=20) meloxicam IV or placebo (n=19), administered once daily as bolus IV injections over 15-30 seconds (two or three doses)...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29496679/acupuncture-for-lumbar-disc-herniation-a-systematic-review-and-meta-analysis
#20
Shujie Tang, Zhuomao Mo, Renwen Zhang
OBJECTIVE: To evaluate evidence for the effectiveness of acupuncture in the treatment of lumbar disc herniation (LDH). METHODS: Electronic databases were searched to identify randomised controlled trials (RCTs) of acupuncture for LDH. A meta-analysis was conducted using RevMan 5.3 and the evidence level was assessed using GRADE methodology. RESULTS: Thirty RCTs involving 3503 participants were included in the study. Meta-analysis showed that acupuncture had a higher total effective rate than lumbar traction (RR=1...
April 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
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