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Meloxicam

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https://www.readbyqxmd.com/read/28435075/development-of-oral-lyophilisates-containing-meloxicam-nanocrystals-using-qbd-approach
#1
Sonia Iurian, Cătălina Bogdan, Ioan Tomuță, Piroska Szabó-Révész, Anita Chvatal, Sorin E Leucuța, Mirela Moldovan, Rita Ambrus
The aim of this study was to develop oral lyophilisates with improved meloxicam (MEL) dissolution, optimizing each step of the preparation by design of experiments. First, meloxicam nanosuspensions were prepared by high-pressure homogenization (HPH), using PVP, Poloxamer or PEG as stabilizers and were subjected to freeze-drying using mannitol as cryoprotectant. The effects of the stabilizers and cryoprotectant were assessed and an optimal formulation was generated within the Design Space where the particle sizes and the PDIs are at their lowest values...
April 20, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28425247/meloxicam-and-diclofenac-do-not-change-vegf-and-pdgf-abserum-levels-of-platelet-rich-plasma
#2
Burkay Utku, Gürhan Dönmez, Gülriz Erişgen, Şenay Akin, Haydar Ali Demirel, Feza Korkusuz, Mahmut Nedim Doral
BACKGROUND/AIM: Platelet-rich plasma (PRP) application has gained widespread interest for musculoskeletal injuries. Nonsteroidal antiinflammatory drugs are frequently used in sports medicine before and/or after PRP application. Our study seeks to determine whether serum levels of platelet-derived growth factor-AB (PDGF-AB) and vascular endothelial growth factor (VEGF) levels of PRP would be affected by nonsteroidal antiinflammatory drugs. MATERIALS AND METHODS: Two different final concentrations of diclofenac (0...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28423583/the-protection-of-meloxicam-against-chronic-aluminium-overload-induced-liver-injury-in-rats
#3
Yang Yang, Qin He, Hong Wang, Xinyue Hu, Ying Luo, Guojuan Liang, Shengnan Kuang, Shaoshan Mai, Jie Ma, Xiaoyan Tian, Qi Chen, Junqing Yang
The present study was designed to observe the protective effect and mechanisms of meloxicam on liver injury caused by chronic aluminium exposure in rats. The histopathology was detected by hematoxylin-eosin staining. The levels of prostaglandin E2, cyclic adenosine monophosphate and inflammatory cytokines were detected by enzyme linked immunosorbent assay. The expressions of cyclooxygenases-2, prostaglandin E2 receptors and protein kinase A were measured by western blotting and immunohistochemistry. Our experimental results showed that aluminium overload significantly damaged the liver...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422384/natural-antioxidant-flavonoids-in-formalin-induced-mice-paw-inflammation-inhibition-of-mitochondrial-sorbitol-dehydrogenase-activity
#4
Ebtehal Mohammad F, Wedad A Hasan, Eman G Mohamed
Flavonoids have reported to cover interesting multiple pharmacological properties. This study evaluated the effect of apigenin or silymarin in paw inflammation induced by formalin in mice. Mice were divided into four groups: I: positive control group; II: apigenin, 3 mg/kg (i.p.); III: silymarin 50 mg/kg (p.o.); IV: meloxicam 10 mg/kg (p.o.), the reference drug. Therapies were administered once a day for 7 days. The curative effects were assessed on inflammatory, oxidative stress and neurotransmitter biomarkers, and apoptosis...
April 19, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28420283/design-and-characteristics-of-gellan-gum-beads-for-modified-release-of-meloxicam
#5
Tomasz Osmałek, Bartłomiej Milanowski, Anna Froelich, Mirosław Szybowicz, Wojciech Białowąs, Marcin Kapela, Piotr Gadziński, Katarzyna Ancukiewicz
The aim of the presented work was to design, formulate and evaluate the properties of low-acyl gellan macro beads with the potential application as carriers for oral delivery of meloxicam (MLX) in the prophylaxis of colorectal cancer. The beads were obtained by means of ionotropic gelation technique. Calcium chloride (1.0%, 9.0 × 10(-2) M) was used as the cross-linking agent. Nine different polymer, drug and surfactant (Tween®80) mixtures were used for production of the beads. The quantitative compositions of the mixtures were generated with the application of the Design of Experiments (DoE) modulus from the STATISTICA Software...
April 19, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28415673/camp-pka-creb-bdnf-signaling-pathway-in-hippocampus-mediates-cyclooxygenase-2-induced-learning-memory-deficits-of-rats-subjected-to-chronic-unpredictable-mild-stress
#6
Ying Luo, Shengnan Kuang, Huan Li, Dongzhi Ran, Junqing Yang
To investigate the mechanism of cyclooxygenase 2 (COX2) in learning and memory impairments in rats subjected to chronic unpredictable mild stress (CUMS), meloxicam was used intragastrically to inhibit the activity of cyclooxygenase 2. Moreover, cyclooxygenase 2 over-expressing or RNA interfere lentivirus was injected intraventricularly to increase or decrease the enzyme's expression, respectively. The body weights and sucrose consumption were used to analyze depressive behaviors, while the Morris water maze and step-down-type passive avoidance tests were carried out to evaluate the learning-memory functions...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413731/meloxicam-ameliorates-the-cartilage-and-subchondral-bone-deterioration-in-monoiodoacetate-induced-rat-osteoarthritis
#7
Előd Nagy, Enikő Vajda, Camil Vari, Sándor Sipka, Ana-Maria Fárr, Emőke Horváth
OBJECTIVE: This study aimed to quantify the cartilage- and subchondral bone-related effects of low-dose and high-dose meloxicam treatment in the late phase of mono-iodoacetate-induced osteoarthritis of the stifle. METHODS: Thirty-four male Wistar rats received intra-articular injection of mono-iodoacetate to trigger osteoarthritis; 10 control animals (Grp Co) received saline. The mono-iodoacetate-injected rats were assigned to three groups and treated from week 4 to the end of week 7 with placebo (Grp P, n = 11), low-dose (GrpM Lo, 0...
2017: PeerJ
https://www.readbyqxmd.com/read/28391757/dose-finding-study-comparing-three-treatments-of-remifentanil-in-cats-anesthetized-with-isoflurane-undergoing-ovariohysterectomy
#8
Marcela L Machado, João Henrique N Soares, Maria Alice Kuster de Albuquerque Gress, Douglas Dos Santos E Castro, Kaleizu Teodoro Rosa, Phillipe Bauer de Araujo Doria, Fabio Otero Ascoli
Objectives Three infusion rates of remifentanil were used in isoflurane-anesthetized cats undergoing ovariohysterectomy. The aim of this study was to identify a dosage regimen that would provide optimal anesthetic and surgical conditions, as well as to compare cardiovascular response to surgical stimulation, postoperative analgesia, anesthetic duration and quality of recovery among the tested remifentanil infusion rates. Methods Twenty-seven client-owned, mixed-breed adult healthy female cats were randomized to receive remifentanil 0...
April 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28389995/cardiovascular-effect-of-inflammation-and-nonsteroidal-anti-inflammatory-drugs-on-renin-angiotensin-system-in-experimental-arthritis
#9
Waheed Asghar, Ali Aghazadeh-Habashi, Fakhreddin Jamali
A co-morbidity of inflammatory conditions is increased cardio-renal risks. Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) which are used to treat pain and inflammation are also associated with increase in such risks. We hypothesized that inflammation and NSAIDs impose the cardio-renal risk through the activation of the renin-angiotensin-system (RAS), a regulating pathway of the renal and cardiovascular homeostasis. We investigated the effect of adjuvant arthritis and NSAIDs on the RAS. Western blotting and ELISA were used to measure the RAS components...
April 7, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28385631/statistically-optimized-fast-dissolving-microneedle-transdermal-patch-of-meloxicam-a-patient-friendly-approach-to-manage-arthritis
#10
Sejal Amodwala, Praveen Kumar, Hetal P Thakkar
INTRODUCTION: The long term administration of Meloxicam for the management of arthritis, a chronic disorder, results in gastrointestinal disturbances leading to poor patient compliance. Considering the favorable molecular weight, therapeutic dose, biological half-life and log P value of meloxicam for transdermal delivery, its fast dissolving microneedle patch, with an ability to breach the stratum corneum and efficiently deliver the cargo to deeper skin layers, were developed. METHODS: Microneedle patch of low molecular weight polyvinyl alcohol and polyvinylpyrrolidone was prepared using Polydimethylsiloxane micromolds...
April 3, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28359810/an-approach-for-chemical-stability-during-melt-extrusion-of-a-drug-substance-with-a-high-melting-point
#11
Abbe Haser, Siyuan Huang, Tony Listro, David White, Feng Zhang
Poorly water-soluble drug substances that exhibit high melting points are difficult to process by melt extrusion due to chemical instability at high temperatures required for processing. The purpose of this study was to extrude meloxicam (melting point 255°C) by optimizing processing parameters and formulation composition. Five extrusion studies were performed: 1) design space, 2) impact of moisture, 3) impact of melt residence time, 4) specific energy optimization, and 5) altered microenvironment pH. Powder X-ray diffraction and polarized light microscopy were used to confirm amorphous conversion...
March 28, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28353025/coxibs-refocus-attention-on-the-cardiovascular-risks-of-non-aspirin-nsaids
#12
Dixon Thomas, Zoya Ali, Seeba Zachariah, Kishore Gnana Sam Sundararaj, Matthew Van Cuyk, Jason C Cooper
Non-steroidal anti-inflammatory drugs (NSAIDs) were differentiated from steroidal anti-inflammatory medicines to help clinicians who needed to use anti-inflammatory agents that were safer than steroids. With market entry of rofecoxib in 1999, NSAIDs were then further classified into traditional NSAIDs and cyclooxygenase (COX)-2 inhibitors (coxibs), the latter posing potentially fewer gastrointestinal risks. In 2005, rofecoxib was withdrawn from the market because of concerns about the risk of heart attack and stroke with long-term use, and clinical practice began focusing more on the cardiovascular versus gastrointestinal safety of coxibs...
March 28, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/28352129/cyclooxygenase-2-signalling-pathway-in-the-cortex-is-involved-in-the-pathophysiological-mechanisms-in-the-rat-model-of-depression
#13
Qi Chen, Ying Luo, Shengnan Kuang, Yang Yang, Xiaoyan Tian, Jie Ma, Shaoshan Mai, Lai Xue, Junqing Yang
This study was designed to investigate the effect of the cortical cyclooxygenase-2 (COX2) pathway on depressive behaviour in rats. Meloxicam, COX2 overexpressed lentivirus and COX2 RNAi lentivirus were administered to Sprague-Dawley rats subjected to chronic unpredictable mild stress (CUMS). Behaviour tests, biochemistry and immunohistochemistry methods, enzyme-linked immunosorbent assays, western blotting and reverse transcription polymerase chain reactions were used to evaluate the changes in rat behaviour and the cortical COX2 pathway...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28349234/prostaglandin-e2-upregulated-trigeminal-ganglionic-sodium-channel-1-7-involving-temporomandibular-joint-inflammatory-pain-in-rats
#14
Peng Zhang, Ye-Hua Gan
Prostaglandin E2 (PGE2) is a key proinflammatory mediator that contributes to inflammatory hyperalgesia. Voltage-gated sodium channel 1.7 (Nav1.7) plays an important role in inflammatory pain. However, the modulation of Nav1.7 in inflammatory pain remains poorly understood. We hypothesized that PGE2 might regulate Nav1.7 expression in inflammatory pain. We here showed that treatment of rat trigeminal ganglion (TG) explants with PGE2 significantly upregulated the mRNA and protein expressions of Nav1.7 through PGE2 receptor EP2...
March 27, 2017: Inflammation
https://www.readbyqxmd.com/read/28334796/determination-of-meloxicam-in-egg-whites-and-yolks-using-reverse-phase-chromatography
#15
Sherry Cox, Joan Bailey, Molly White, Kristen Gordon, Marcy Souza
A new method of analysis has been developed and validated for the determination of meloxicam in egg whites and yolks. Following a liquid extraction for the whites and a solid phase extraction for the yolks, samples were separated on an XBridge C18 column and quantified using ultraviolet detection at 360 nm. The mobile phase was a mixture of water with glacial acetic acid and acetonitrile, with a flow rate of 1 mL/min. The procedure produced a linear graph over the concentration range 5-1500 ng/mL with a lower limit of quantification of 5 ng/mL...
March 2, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28315645/pharmacokinetic-profiles-of-meloxicam-and-sustained-release-buprenorphine-in-prairie-dogs-cynomys-ludovicianus
#16
Cynthia D Cary, Nicole L Lukovsky-Akhsanov, Nadia F Gallardo-Romero, Cassandram M Tansey, Sharon D Ostergaard, Willie D Taylor, Clint N Morgan, Nathaniel Powell, George W Lathrop, Christina L Hutson
In this study, we evaluated the pharmacokinetic profiles of meloxicam and sustained-release (SR) buprenorphine in prairie dogs. The 4 treatment groups were: low-dose meloxicam (0.2 mg/kg SC), high-dose meloxicam (4 mg/kg SC), low-dose buprenorphine SR (0.9 mg/kg SC), and high-dose buprenorphine SR (1.2 mg/kg SC). The highest plasma concentrations occurred within 4 h of administration for both meloxicam treatment groups. The therapeutic range of meloxicam in prairie dogs is currently unknown. However, as compared with the therapeutic range documented in other species (0...
March 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28240949/pharmacokinetics-of-meloxicam-after-intramuscular-and-oral-administration-of-a-single-dose-to-american-flamingos-phoenicopertus-ruber
#17
Jennifer L Boonstra, Sherry K Cox, Tomas Martin-Jimenez
OBJECTIVE To determine pharmacokinetics after IM and oral administration of a single dose of meloxicam to American flamingos (Phoenicopertus ruber). ANIMALS 14 adult flamingos. PROCEDURES Flamingos were allocated to 2 groups. Each group received a dose of meloxicam (1 mg/kg) by the IM or oral route. After a 4-week washout period, groups received meloxicam via the other route of administration. Plasma meloxicam concentrations were measured with high-performance liquid chromatography. Data for each bird were analyzed...
March 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28237682/the-influence-of-demeanor-on-scores-from-two-validated-feline-pain-assessment-scales-during-the-perioperative-period
#18
Mandy Buisman, Michelle M M Hasiuk, Marta Gunn, Daniel S J Pang
OBJECTIVE: To evaluate the effects of demeanor on validated pain assessment scales. STUDY DESIGN: Prospective, blind, clinical trial. ANIMAL POPULATION: Thirty three adult domestic cats scheduled for orchiectomy. METHODS: Cats were assessed for pain pre (baseline) and 1, 2, 4 hours postoperatively using two validated pain scales [Composite Measures Pain Scale-Feline (rCMPS-F) and UNESP-Botucatu multidimensional composite pain scale (psychomotor and pain expression subscales; U-B MCPS-psych and -painex)], and a demeanor scale...
January 8, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28229809/pharmacokinetic-profiles-of-meloxicam-and-sustained-release-buprenorphine-in-prairie-dogs-cynomys-ludovicianus
#19
Cynthia Cary, Nicole Lukovsky-Akhsanov, Nadia Gallardo-Romero, Cassandra Tansey, Sharon Ostergaard, Willie Taylor, Clint Morgan, Nathaniel Powell, George Lathrop, Christina Hutson
In this study, we evaluated the pharmacokinetic profiles of meloxicam and sustained-release (SR) buprenorphine in prairiedogs. The 4 treatment groups were: low-dose meloxicam (0.2 mg/kg SC), high-dose meloxicam (4 mg/kg SC), low-dosebuprenorphine SR (0.9 mg/kg SC), and high-dose buprenorphine SR (1.2 mg/kg SC). The highest plasma concentrationsoccurred within 4 h of administration for both meloxicam treatment groups. The therapeutic range of meloxicam in prairiedogs is currently unknown. However, as compared with the therapeutic range documented in other species (0...
February 22, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28222837/use-of-the-rat-grimace-scale-to-evaluate-neuropathic-pain-in-a-model-of-cervical-radiculopathy
#20
Blythe H Philips, Christine L Weisshaar, Beth A Winkelstein
Although neck and low-back pain are common sources of neuropathic pain with high societal costs, the pathophysiology of neuropathic pain is not well-defined. Traditionally, most rodent pain studies rely on evoked reflex-based testing to measure pain. However, these testing methods do not reveal spontaneous pain, particularly early after injury. The rat grimace scale (RGS) for quantifying spontaneous pain has been validated after visceral, incisional, orthopedic, and inflammatory insults but not neuropathic pain...
February 1, 2017: Comparative Medicine
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