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Meloxicam

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https://www.readbyqxmd.com/read/27904016/the-measurement-of-meloxicam-and-meloxicam-metabolites-in-rat-plasma-using-a-high-performance-liquid-chromatography-ultraviolet-spectrophotometry-method
#1
Aoi Miyamoto, Takahiko Aoyama, Yoshiaki Matsumoto
A high-performance liquid chromatography-ultraviolet spectrophotometry (HPLC-UV) method for the determination of meloxicam (MEL) and meloxicam metabolites (5'-hydroxy meloxicam (5-HMEL) and 5'-carboxy meloxicam (5-CMEL)) has been developed. After extraction of MEL, 5-HMEL, and 5-CMEL from rat plasma using Oasis HLB cartridges, the extracts were separated with a Luna C18 (2) 100 A column (5 μm, 4.6 × 150 mm, Phenomenex) using a mobile phase of 50 mM phosphate buffer (pH 2.15, solvent A) and acetonitrile (solvent B) at a flow rate of 0...
December 1, 2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27901389/population-pharmacokinetics-of-a-single-dose-of-meloxicam-after-oral-and-intramuscular-administration-to-captive-lesser-flamingos-phoeniconaias-minor
#2
Martín A Zordan, Mark G Papich, Ashley A Pich, Katy M Unger, Carlos R Sánchez
OBJECTIVE To determine the pharmacokinetics of a single dose of meloxicam after IM and oral administration to healthy lesser flamingos (Phoeniconaias minor) by use of a population approach. ANIMALS 16 healthy captive lesser flamingos between 1 and 4 years of age. PROCEDURES A single dose of meloxicam (0.5 mg/kg) was administered IM to each bird, and blood samples were collected from birds at 3 (n = 13 birds), 2 (2), or 1 (1) selected point between 0 and 13 hours after administration, with samples collected from birds at each point...
December 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27875913/development-and-optimization-of-a-meloxicam-%C3%AE-cyclodextrin-complex-for-orally-disintegrating-tablet-using-statistical-analysis
#3
Ahmad Ainurofiq, Syaiful Choiri
The purpose of this research was to develop an inclusion complex of meloxicam (MEL)/β-cyclodextrin (β-CD) incorporated into an orally disintegrating tablet (ODT), using statistical analysis to optimize the ODT formulation based on a quality by design (QbD) approach. MEL/β-CD complexation was performed by kneading, co-precipitation, and spray drying methods under different molar ratios. Fourier transform infrared spectroscopy, X-Ray diffraction, and thermal analysis were utilized to evaluate the complexes...
November 22, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27845312/-improvement-of-the-efficacy-and-safety-of-the-treatment-of-patients-with-low-back-pain
#4
P R Kamchatnov
Low back pain (LBP) is an extremely widespread syndrome in the population. Nonsteroidal Inflammatory drugs are most frequently used in treatment of patients with LBP. The use of these drugs causes adverse effects, the risk of which can be minimized. To decrease the risk, B-group vitamins are used in the complex treatment. The possibility of simultaneous using of artrozan (meloxicam) and cyanocobalamine (B-group vitamin complex) in the treatment of LBP is considered.
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27842798/synthesis-cox-1-2-inhibition-activities-and-molecular-docking-study-of-isothiazolopyridine-derivatives
#5
Piotr Świątek, Malgorzata Strzelecka, Rafal Urniaz, Katarzyna Gębczak, Tomasz Gębarowski, Kazimierz Gąsiorowski, Wieslaw Malinka
One of the main challenges for nowadays medicine is drugs selectivity. In COX-1 and COX-2, the active sites are composed of the same group of amino acids with the exception of the only one residue in position 523, in COX-1 is an isoleucine, while in COX-2 is a valine. Here, we presented a series of isothiazolopyridine/benzisothiazole derivatives substituted differently into an isothiazole ring, which were synthesized and investigated for their potencies to inhibit COX-1 and COX-2 enzymes by colorimetric inhibitor screening assay...
November 3, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27833182/appreciation-for-analysis-of-how-levonorgestrel-works-and-reservations-with-the-use-of-meloxicam-as-emergency-contraception
#6
COMMENT
A Patrick Schneider, Christopher Kubat, Christine M Zainer
This paper is a response to Dr. Kathleen Raviele's recent article on her critical analysis of the use of levonorgestrel given to women postsexual assault and her suggestion that the use of Meloxicam may be an ethical alternative.
February 2016: Linacre Quarterly
https://www.readbyqxmd.com/read/27775559/synthesis-spatial-structure-and-analgesic-activity-of-sodium-3-benzylaminocarbonyl-1-methyl-2-2-dioxo-1h-2%C3%AE-%C3%A2-1-benzothiazin-4-olate-solvates
#7
Igor V Ukrainets, Lidiya A Petrushova, Svitlana V Shishkina, Lina A Grinevich, Galina Sim
In order to obtain and then test pharmocologically any possible conformers of the new feasible analgesic N-benzyl-4-hydroxy-1-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxamide, its 4-O-sodium salt was synthesized using two methods. X-ray diffraction study made possible to determine that, depending on the chosen synthesis conditions, the above-mentioned compound forms either monosolvate with methanol or monohydrate, where organic anion exists in the form of three different conformers. Pharmacological testing of the two known pseudo-enantiomeric forms of the original N-benzylamide and of the two solvates of its sodium salt was performed simultaneously under the same conditions and in equimolar doses...
October 19, 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/27766224/improvement-of-meloxicam-solubility-using-a-%C3%AE-cyclodextrin-complex-prepared-via-the-kneading-method-and-incorporated-into-an-orally-disintegrating-tablet
#8
Ahmad Ainurofiq, Syaiful Choiri, Muhamad Ali Azhari, Chaterin Romauli Siagian, Bambang Budi Suryadi, Fea Prihapsara, Sholichah Rohmani
Purpose: The aim of this research was to formulate and develop an orally disintegrating tablet (ODT) that incorporated a MEL/β-CD complex, using a quality by design (QbD) approach to enhance solubility and drug release. Methods: Multiple regression linear analysis was conducted to develop the kneading process and ODT formulation. Mixing time and amount of solvent were used as independent variables in kneading process optimisation, while the superdisintegrants were used to obtain the desired formulation. Fourier transform infrared spectroscopy and differential scanning calorimetry were performed for complex characterization...
September 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27725022/inappropriate-medicine-prescribing-in-older-south-africans-a-cross-sectional-analysis-of-medicine-claims-data
#9
J A Van Heerden, J R Burger, J J Gerber
BACKGROUND: Prescribing for older patients is a well-recognised problem, and inappropriate items are prescribed frequently. Several tools and criteria are available to promote rational prescribing in older patients. OBJECTIVE: To determine the prevalence of potentially inappropriate prescriptions (PIPs) in older South African patients. METHODS: A retrospective drug utilisation review was conducted using medicine claims data over a 1-year period...
September 9, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27691947/pharmacokinetic-evaluation-of-meloxicam-after-intravenous-and-intramuscular-administration-in-nile-tilapia-oreochromis-niloticus
#10
Daniel V Fredholm, Natalie D Mylniczenko, Butch KuKanich
Critically evaluating the pharmacokinetic behavior of a drug in the body provides crucial information about how to effectively treat a patient. Pharmacokinetic studies that exist in fish have primarily focused on drugs used to treat infectious disease, with minimal attention given to analgesic drugs. The objective of this study was to determine the pharmacokinetics of meloxicam (1 mg/kg) in Nile tilapia ( Oreochromis niloticus ) (n = 12). A single dose of meloxicam was administered either i.v. or i.m. Blood samples were obtained at predetermined times after drug injection...
September 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/27688417/the-influence-of-different-nonsteroidal-anti-inflammatory-drugs-on-alveolar-bone-in-rats-an-experimental-study
#11
Mujgan Gungor Hatipoglu, Sermet Inal, Sahin Kabay, Muhammet Kasim Cayci, Ayşenur Deger, Halil Isa Kuru, Sayit Altikat, Gizem Akkas
THE AIM: The aim of this study was to investigate the effect of dexketoprofen trometamol, meloxicam, diclofenac sodium on any untreated alveolar bone when they are used as drugs for another indication. MATERIALS AND METHODS: Twenty eight male Spraque-Dawley rats were randomized into four groups as dexketoprofen trometamol (Group I), meloxicam (Group II), diclofenac sodium (Group III) and control group. Nonsteroidal anti-inflammatory drugs (NSAID) were administered after a fibula fracture for 10 days...
December 2015: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/27687548/nsaids-diclofenac-indomethacin-and-meloxicam-highly-upregulate-expression-of-icam-1-and-cox-2-induced-by-x-irradiation-in-human-endothelial-cells
#12
Yoshihiko Uehara, Yasuhiko Murata, Soichiro Shiga, Yoshio Hosoi
BACKGROUND: It is well known that radiation exposure to the heart and the use of non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of myocardial infarction (MI). Some NSAIDs are also known to act synergistically with ionizing radiation and have radio-sensitizing effects in radiotherapy. These evidences suggest that NSAIDs may affect the risk of MI after radiation exposure to the heart. In the present study, we investigated effects of NSAIDs on radiation-induced expression of cell adhesion molecules and COX-2, which are associated with inflammation and an increased risk of MI, in human endothelial cells...
October 28, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27664321/polymeric-nanocapsules-as-a-technological-alternative-to-reduce-the-toxicity-caused-by-meloxicam-in-mice
#13
Benonio T Villalba, Francine R Ianiski, Ane G Vogt, Mikaela P Pinz, Angélica S Reis, Rodrigo A Vaucher, Mauro P Soares, Ethel A Wilhelm, Cristiane Luchese
This study determined whether meloxicam in nanocapsules modifies stomach and liver damage caused by free meloxicam in mice. Male Swiss mice were treated with blank nanocapsules or meloxicam in nanocapsules or free meloxicam (10 mg/kg, intragastrically, daily for five days). On the seventh day, blood was collected to determine biochemical markers (glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, total bilirubin, unconjugated bilirubin, albumin and alkaline phosphatase). Stomachs and livers were removed for histological analysis...
November 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27663371/effects-of-administration-of-a-local-anaesthetic-and-or-an-nsaid-and-of-docking-length-on-the-behaviour-of-piglets-during-5h-after-tail-docking
#14
M S Herskin, P Di Giminiani, K Thodberg
In many countries, piglets are tail docked to prevent tail biting. The aim of this study was 1) to evaluate the efficacy of a local anaesthetic and/or NSAID to reduce pain caused by tail docking; and 2) to examine interactions with docking length. This was examined in 295 piglets docked by hot iron cautery 2-4days after birth and based on behaviour during docking as well as the following 5h. The study involved three main factors: local anaesthetic (Lidocain), NSAID (Meloxicam) and docking length. Either 100%, 75%, 50% or 25% of the tails were left on the body of the piglets...
October 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27625299/acute-central-effects-of-alarin-on-the-regulation-on-energy-homeostasis
#15
Alexandra Mikó, Nóra Füredi, Judit Tenk, Ildikó Rostás, Szilvia Soós, Margit Solymár, Miklós Székely, Márta Balaskó, Susanne M Brunner, Barbara Kofler, Erika Pétervári
Hypothalamic neuropeptides influence the main components of energy balance: metabolic rate, food intake, body weight as well as body temperature, by exerting either an overall anabolic or catabolic effect. The contribution of alarin, the most recently discovered member of the galanin peptide family to the regulation of energy metabolism has been suggested. Our aim was to analyze the complex thermoregulatory and food intake-related effects of alarin in rats. Adult male Wistar rats received different doses of alarin (0...
September 5, 2016: Neuropeptides
https://www.readbyqxmd.com/read/27612525/prevention-of-trismus-with-different-pharmacological-therapies-after-surgical-extraction-of-impacted-mandibular-third-molar
#16
Edin Selimović, Lejla Ibrahimagić-Šeper, Ibrahim Šišić, Suad Sivić, Senad Huseinagić
Aim To assess prevention and reduction of trismus after surgically extracted impacted mandibular third molars with individual and combined therapy with corticosteroids and anti-inflammatory analgesics. Methods The research included 60 randomly selected patients (3 groups) attended to the Dental Oral Surgery of the Public Institution Healthcare Center Zenica during the period January-December 2008. Patients of both genders, 18-45 years of age, were presented without pain and other inflammatory symptoms at the time of surgery...
February 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/27611057/investigation-and-mathematical-description-of-the-real-driving-force-of-passive-transport-of-drug-molecules-from-supersaturated-solutions
#17
Eniko Borbas, Balint Sinko, Oksana Tsinman, Konstantin Tsinman, Eva Kiserdei, Balazs Demuth, Attila Balogh, Brigitta Bodak, Andras Domokos, Gergo Dargo, György T Balogh, Zsombor K Nagy
The aim of this study was to investigate the impact of formulation excipients and solubilizing additives on dissolution, supersaturation and membrane transport of an active pharmaceutical ingredient (API). When a poorly water-soluble API is formulated to enhance its dissolution, additives, such as surfactants, polymers and cyclodextrins have an effect not only on dissolution profile, but also on the measured physicochemical properties (solubility, pKa, permeability) of the drug while the excipient is present, therefore also affect the driving force of membrane transport...
September 9, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27597532/pharmacokinetics-of-meloxicam-after-intravenous-intramuscular-and-oral-administration-of-a-single-dose-to-african-grey-parrots-psittacus-erithacus
#18
A Montesinos, M Ardiaca, J A Gilabert, C Bonvehí, J Oros, T Encinas
Meloxicam is a nonsteroidal anti-inflammatory drug commonly used in avian species. In this study, the pharmacokinetic parameters for meloxicam were determined following single intravenous (i.v.), intramuscular (i.m.) and oral (p.o.) administrations of the drug (1 mg/kg·b.w.) in adult African grey parrots (Psittacus erithacus; n = 6). Serial plasma samples were collected and meloxicam concentrations were determined using a validated high-performance liquid chromatography assay. A noncompartmental pharmacokinetic analysis was performed...
September 6, 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27596333/meloxicam-fails-to-augment-the-reno-protective-effects-of-soluble-epoxide-hydrolase-inhibition-in-streptozotocin-induced-diabetic-rats-via-increased-20-hete-levels
#19
Mohamed M Katary, Chelsey Pye, Ahmed A Elmarakby
The pro-inflammatory cyclooxygenase (COX)-derived prostaglandins and the anti-inflammatory cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids (EETs) play an important role in the regulation of renal injury. The current study examined whether COX inhibition augments the reno-protective effects of increased EETs levels via inhibiting EETs degradation by soluble epoxide hydrolase (sEH) in diabetic rats. Streptozotocin (50mg/kg, i.v) was used to induce diabetes in male Sprague Dawley rats. Rats were then divided into 5 groups (n=6-8); control non diabetic, diabetic, diabetic treated with the sEH inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB), diabetic treated with the COX inhibitor meloxicam and diabetic treated with meloxicam plus t-AUCB for 2 months...
September 2, 2016: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/27581248/pharmacokinetic-drug-drug-interactions-between-vonoprazan-and-low-dose-aspirin-or-nonsteroidal-anti-inflammatory-drugs-a-phase-2-open-label-study-in-healthy-japanese-men
#20
Yuuichi Sakurai, Madoka Shiino, Sayako Horii, Hiroyuki Okamoto, Koki Nakamura, Akira Nishimura, Yukikuni Sakata
BACKGROUND: Gastroprotective agents are recommended for patients receiving low-dose aspirin (LDA) or nonsteroidal anti-inflammatory drugs (NSAIDs). Vonoprazan is a potassium-competitive acid blocker recently approved for the prevention of peptic ulcer recurrence in patients receiving LDA or NSAIDs. METHODS: This phase 2, open-label, single-center study in healthy Japanese males evaluated drug-drug interactions between vonoprazan 40 mg and LDA (100 mg) or NSAIDs [loxoprofen sodium (60 mg), diclofenac sodium (25 mg), or meloxicam (10 mg)] and vice versa...
August 31, 2016: Clinical Drug Investigation
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