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https://www.readbyqxmd.com/read/28222837/use-of-the-rat-grimace-scale-to-evaluate-neuropathic-pain-in-a-model-of-cervical-radiculopathy
#1
Blythe H Philips, Christine L Weisshaar, Beth A Winkelstein
Although neck and low-back pain are common sources of neuropathic pain with high societal costs, the pathophysiology of neuropathic pain is not well-defined. Traditionally, most rodent pain studies rely on evoked reflex-based testing to measure pain. However, these testing methods do not reveal spontaneous pain, particularly early after injury. The rat grimace scale (RGS) for quantifying spontaneous pain has been validated after visceral, incisional, orthopedic, and inflammatory insults but not neuropathic pain...
February 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28216685/comparative-efficacy-of-oral-meloxicam-and-phenylbutazone-in-2-experimental-pain-models-in-the-horse
#2
Heidi Banse, Alastair E Cribb
The efficacy of oral phenylbutazone [PBZ; 4.4 mg/kg body weight (BW), q12h], a non-selective non-steroidal anti-inflammatory drug (NSAID), and oral meloxicam (MXM; 0.6 mg/kg BW, q24h), a COX-2 selective NSAID, were evaluated in 2 experimental pain models in horses: the adjustable heart bar shoe (HBS) model, primarily representative of mechanical pain, and the lipopolysaccharide-induced synovitis (SYN) model, primarily representative of inflammatory pain. In the HBS model, PBZ reduced multiple indicators of pain compared with the placebo and MXM...
February 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28216684/perioperative-analgesic-use-by-ontario-veterinarians-2012
#3
Jessica Reimann, Cate Dewey, Shane W Bateman, Carolyn Kerr, Ron Johnson
The objectives of this study were to describe the routine use of analgesics by Ontario veterinarians for common surgeries in dogs and cats, and to compare routine use of analgesics between species and surgeries, using Chi-square analyses. In total, 239 veterinarians responded to the questionnaires; a response rate of 13.1%. Fifty-two percent to 79% of veterinarians used meloxicam for both species and all surgeries. Approximately 9% of veterinarians did not use analgesics for dog ovariohysterectomy and castration, while 16% to 22% did not use analgesics for these surgeries in cats...
February 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28207313/continuous-radiotelemetric-monitoring-of-intragastric-ph-in-a-dog-with-peptic-ulceration
#4
Michael B Lane, Jeanne C Larson, Jennifer E Stokes, M Katherine Tolbert
CASE DESCRIPTION A 6-year-old castrated male Boxer was evaluated for a 5-week history of frequent vomiting, melena, and signs of abdominal pain following accidental ingestion of 5 to ten 15-mg meloxicam tablets (approx ingested dose, 3.1 to 6.2 mg/kg [1.4 to 2.8 mg/lb]). CLINICAL FINDINGS Clinical signs persisted despite 3 weeks of treatment with sucralfate (41.8 mg/kg [19 mg/lb], PO, q 8 h) and omeprazole (0.8 mg/kg [0.36 mg/lb], PO, q 24 h). Results of a CBC and serum biochemical analysis were unremarkable...
March 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28198061/antiinflammatory-oxicams-as-multi-donor-ligand-systems-ph-and-solvent-dependent-coordination-modes-of-meloxicam-and-piroxicam-to-ru-and-os
#5
Farhana Aman, Muhammad Hanif, Mario Kubanik, Adnan Ashraf, Tilo Soehnel, Stephen Jamieson, Waseeq Siddiqui, Christian Hartinger
The nitrogen- and sulfur-containing 1,2-benzothiazines meloxicam and piroxicam are widely used as nonsteroidal antiinflammatory drugs. Intrigued by the presence of multiple donor atoms and therefore a potentially rich coordination chemistry, we prepared a series of organometallic Ru and Os compounds with meloxicam and piroxicam featuring either as mono- or bidentate ligand systems. The choice of the solvent and the pH value was identified as the critical parameter to achieve selectively mono- or bidentate coordination...
February 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28192045/radio-transmitter-implantation-and-movement-in-the-wild-timber-rattlesnake-crotalus-horridus
#6
Vanessa Hale, Brian MacGowan, Lorraine Corriveau, David Huse, Andrea F T Currylow, Steve Thompson
Radiotelemetry transmitters have become critical to studies of wildlife ecology. However, little is known about how transmitter implantation surgery affects the mobility of some species, including the timber rattlesnake, Crotalus horridus . Tracking snake movement can provide insights into the effects of transmitter implantation. During 2007-2011, 71 radio transmitters were surgically implanted intracoelomically in 47 timber rattlesnakes. Over 20 of these snakes underwent surgery at least twice in 5 yr to replace old transmitters...
February 13, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28162656/-409-an-evaluation-of-the-efficacy-and-safety-of-n1539-a-novel-intravenous-formulation-of-nanocrystal-meloxicam-in-subjects-with-moderate-to-severe-pain-following-hysterectomy
#7
R Mack, A Freyer, W Du
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162625/-380-a-novel-application-of-the-medication-event-monitoring-system-mems-to-track-rescue-medication-use-in-a-phase-3-study-of-low-dose-solumatrix-meloxicam-in-patients-with-osteoarthritis-oa-pain
#8
R Altman, A Gibofsky, A Kivitz, D Solorio, C Sheridan, C Young
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28161667/aerodynamic-properties-and-in-silico-deposition-of-meloxicam-potassium-incorporated-in-a-carrier-free-dpi-pulmonary-system
#9
Anita Chvatal, Árpád Farkas, Imre Balásházy, Piroska Szabó-Révész, Rita Ambrus
Dry powder inhalers (DPIs) have been among the fastest developing inhaler forms in the past decades. Researches are focusing on the formulation of carrier-free powders to obtain a higher deep-lung deposition and hereby to increase the effectiveness of the medicine. The aim of our study was to prepare a carrier-free dry powder formulation of meloxicam potassium (MP), a novel salt form of meloxicam, using a one-step co-spray drying technology. Different types of excipients were used to modify the crystal structure and to increase aerosolization efficacy...
February 1, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28153013/effects-of-dexamethasone-and-meloxicam-on-borrelia-burgdorferi-induced-inflammation-in-glial-and-neuronal-cells-of-the-central-nervous-system
#10
Geeta Ramesh, Alejandra N Martinez, Dale S Martin, Mario T Philipp
BACKGROUND: Lyme neuroborreliosis (LNB), caused by the spirochete Borrelia burgdorferi (Bb), affects both the central and peripheral nervous systems. Previously, we reported that in a model of acute LNB in rhesus monkeys, treatment with the anti-inflammatory drug dexamethasone significantly reduced both pleocytosis and levels of cerebrospinal fluid (CSF) immune mediators that were induced by Bb. Dexamethasone also inhibited the formation of inflammatory, neurodegenerative, and demyelinating lesions in the brain and spinal cord of these animals...
February 2, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28138901/formulation-and-development-of-di-dependent-microparticulate-system-for-colon-specific-drug-delivery
#11
Mayur M Patel
Colorectal cancer (CRC) is the third most common cancer globally and the second most common cause of cancer-related deaths. Site-specific delivery of drugs leads to an increase in the availability of drugs at the targeted region. The objective of the present investigation was to develop a dually functional microparticulate colon-targeted drug delivery system of meloxicam for potential application in the prophylaxis of colorectal cancer. Chitosan microspheres were prepared by using emulsification-chemical cross-linking technique...
January 30, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28119220/chitosan-cross-linked-poly-acrylic-acid-hydrogels-drug-release-control-and-mechanism
#12
Yiming Wang, Jie Wang, Zhenyu Yuan, Haoya Han, Tao Li, Li Li, Xuhong Guo
Chitosan has been used to cross-link poly(acrylic acid) to give three pH-sensitive hydrogels designed to control the release of the drugs amoxicillin and meloxicam. The extent of cross-linking and solution pH was found to dominate the swelling behavior of these hydrogels as shown by scanning electron microscopy and swelling time dependencies. The rates of release of amoxicillin and meloxicam from the loaded hydrogels increased with increase in pH consistent with the extent of hydrogen bonding between hydrogel components and between the hydrogel and the drugs being important determinants of release rate...
January 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28117318/synthesis-structure-and-analgesic-properties-of-halogen-substituted-4-hydroxy-2-2-dioxo-1h-2%C3%AE-%C3%A2-1-benzothiazine-3-carboxanilides
#13
Igor V Ukrainets, Lidiya A Petrushova, Svitlana V Shishkina, Lyudmila V Sidorenko, Galina Sim, Olga V Kryvanych
As potential new analgesics, the corresponding 4-hydroxy-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxanilides have been obtained by amidation of ethyl 4-hydroxy-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxylate with aniline and its halogenated analogsin boiling dry xylene. The peculiarities of the mass and nuclear magnetic resonance (¹Н and (13)С) spectra of the synthesized compounds are discussed. Using X-ray diffraction analysis, the ability of the compounds to form stable solvates with N,N-dimethylformamide has been shown on the example of 4-bromo-substituted derivative...
June 17, 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28117315/the-study-of-structure-analgesic-activity-relationships-in-a-series-of-4-hydroxy-2-2-dioxo-1h-2%C3%AE-%C3%A2-1-benzothiazine-3-carboxylic-acid-toluidides-and-xylidides
#14
Igor V Ukrainets, Lidiya A Petrushova, Lyudmila V Sidorenko, Alexandra A Davidenko, Marina A Duchenko
In continuing the search for new analgesics among derivatives of 2,1-benzothiazines, a series of corresponding toluidides and xylidides of 4-hydroxy-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxylic acid has been synthesized by the reaction of ethyl 4-hydroxy-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxylate with equimolar amounts of mono- and dimethyl-substituted anilides in boiling dry xylene. Their structure has been confirmed by the data of elemental analysis, nuclear magnetic resonance (NMR) spectroscopy (¹Н and (13)С), as well as mass spectrometry...
April 18, 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28107073/choroidal-vasculopathy-and-retinal-detachment-in-a-bald-eagle-haliaeetus-leucocephalus-with-lead-toxicosis
#15
Ramzi Eid, David Sanchez-Migallon Guzman, Krista A Keller, K Tomo Wiggans, Christopher J Murphy, Elise E B LaDouceur, M Kevin Keel, Christopher M Reilly
A subadult male bald eagle ( Haliaeetus leucocephalus ) was presented for severe depression and weakness. Physical examination findings included depressed mentation, dehydration, sternal recumbency, poor body condition, and bilateral, whole-head, horizontal nystagmus. A heavy-metal panel was performed, and blood lead levels were 6.1 ppm. Treatment for lead poisoning was initiated, including subcutaneous fluids and parenteral calcium-disodium ethylenediaminetetraacetic acid, ceftiofur, and meloxicam. Ophthalmic examination findings included absent menace response, absent dazzle reflex, slow and incomplete direct pupillary light reflex, mild anterior uveitis, incipient cataracts, multifocal retinal tears, and retinal separation in both eyes...
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28076506/stem-cells-from-adipose-tissue-improve-the-time-of-wound-healing-in-rats
#16
Camila Melo Ohashi, Fabio Alves Morikawa Caldeira, Denilson José Silva Feitosa-Junior, André Lopes Valente, Paulo Roberto Witter Dutra, Moysés Dos Santos Miranda, Simone do Socorro Damasceno Santos, Marcus Vinicius Henriques Brito, Otávio Mitio Ohashi, Edson Yuzur Yasojima
PURPOSE: To evaluate the Adipose Stem Cells (ACS) therapy efficacy on the time and quality of wound healing process in rats. METHODS: Nine male Wistar rats were randomly distributed into three groups I) 7 days of healing; II) 14 days of healing; III) 21 days of healing. Four incisions were made on the dorsal surface of each rat and then treated with intralesional ACS, meloxicam, and no treatment and ACS+meloxicam. Macroscopic evaluation was measured by percentage of healing and histopathological by hematoxylin-eosin was performed...
December 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28046151/pain-alleviation-during-castration-of-piglets-a-comparative-study-of-different-farm-options
#17
F Gottardo, A Scollo, B Contiero, A Ravagnani, G Tavella, D Bernardini, G M De Benedictis, S A Edwards
Pain alleviation associated with castration of piglets is an important welfare issue. The present study compares the effect of different approaches and products suitable for farmer use, with the aim to alleviate pain due to castration in piglets. A randomized within-litter design, with 28 replicate litters, compared 7 treatments: handling () restraint of the piglet and manipulation of the scrotum, castration without pain relief (), 2 treatments (, ) with different concentrations of tetracaine (2 and 6%) applied topically 10 min before and immediately post-surgery, and 3 treatments with i...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/28044198/meloxicam-medication-reduces-orthodontically-induced-dental-root-resorption-and-tooth-movement-velocity-a-combined-in-vivo-and-in-vitro-study-of-dental-periodontal-cells-and-tissue
#18
Christian Kirschneck, Matthias Meier, Kathrin Bauer, Peter Proff, Jochen Fanghänel
Non-steroidal anti-inflammatory drugs (NSAID) are used to alleviate pain sensations during orthodontic therapy but are also assumed to interfere with associated pseudo-inflammatory reactions. In particular, the effects of partially selective COX-2 inhibition over the constitutively expressed COX-1 (11:1) on periodontal cells and tissue, as induced by the NSAID meloxicam, remain unclear. We investigate possible adverse side-effects and potentially useful beneficial effects during orthodontic therapy and examine underlying cellular and tissue reactions...
January 3, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28005437/self-nanoemulsifying-granules-snegs-of-meloxicam-preparation-characterization-molecular-modeling-and-evaluation-of-in-vivo-anti-inflammatory-activity
#19
Vidhi J Parekh, Namita D Desai, Mushtaque S Shaikh, Ujwala A Shinde
Meloxicam, a BCS class II drug belonging to the class of NSAIDs is indicated in conditions of rheumatoid arthritis, ankylosing spondylitis and osteoarthritis in which rapid onset of drug action is desired to reduce inflammation and pain. The objective of the study was to thus develop Self Nanoemulsifying Granules (SNEGs) of Meloxicam (MLX) for enhancement of solubility; and subsequently dissolution rate, thus aiming for a faster onset of action. Preliminary studies along with molecular modeling studies were carried out for selection of appropriate lipids, surfactants and cosurfactants for the development of MLX-loaded Self Nanoemulsifying preconcentrate (SNEP)...
April 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27980849/crystal-structure-of-a-2-1-co-crystal-of-meloxicam-with-acetyl-endi-carb-oxy-lic-acid
#20
Christian Tantardini, Sergey G Arkhipov, Ksenya A Cherkashina, Alexander S Kil'met'ev, Elena V Boldyreva
The pharmaceutical 2:1 co-crystal of meloxicam [MXM; systematic name: 4-hy-droxy-2-methyl-N-(5-methyl-thia-zol-2-yl)-2H-1,2-benzo-thia-zine-3-carboxamide 1,1-dioxide] with acetyl-enedi-carb-oxy-lic acid (ACA; systematic name: but-2-ynedioic acid), crystallizes with one MXM mol-ecule and half an ACA mol-ecule in the asymmetric unit, C14H13N3O4S2·0.5C4H2O4. The mid-point of the triple bond of ACA is located on an inversion centre. In the crystal, the two stereoisomers of MXM with respect to the N atom of the sulfonamide group are related by the inversion centre...
December 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
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