keyword
MENU ▼
Read by QxMD icon Read
search

Meloxicam

keyword
https://www.readbyqxmd.com/read/28770976/non-steroidal-anti-inflammatory-drugs-nsaids-for-chronic-non-cancer-pain-in-children-and-adolescents
#1
REVIEW
Christopher Eccleston, Tess E Cooper, Emma Fisher, Brian Anderson, Nick Mr Wilkinson
BACKGROUND: Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in children is a major public health concern of high significance in most parts of the world. While in the past pain was largely dismissed and was frequently left untreated, views on children's pain have changed over time, and relief of pain is now seen as important...
August 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28768536/a-novel-composite-formulation-of-palmitoylethanolamide-and-quercetin-decreases-inflammation-and-relieves-pain-in-inflammatory-and-osteoarthritic-pain-models
#2
Domenico Britti, Rosalia Crupi, Daniela Impellizzeri, Enrico Gugliandolo, Roberta Fusco, Carlo Schievano, Valeria Maria Morittu, Maurizio Evangelista, Rosanna Di Paola, Salvatore Cuzzocrea
BACKGROUND: Osteoarthritis (OA) is a common progressive joint disease in dogs and cats. The goal of OA treatment is to reduce inflammation, minimize pain, and maintain joint function. Currently, non-steroidal anti-inflammatory drugs (e.g., meloxicam) are the cornerstone of treatment for OA pain, but side effects with long-term use pose important challenges to veterinary practitioners when dealing with OA pain. Palmitoylethanolamide (PEA) is a naturally-occurring fatty acid amide, locally produced on demand by tissues in response to stress...
August 2, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28738003/pharmacokinetics-and-egg-residues-after-oral-administration-of-a-single-dose-of-meloxicam-in-domestic-chickens-gallus-domesticus
#3
Marcy J Souza, Joan B Bergman, Molly S White, Kristen I Gordon, Lillian E Gerhardt, Sherry K Cox
OBJECTIVE To determine the pharmacokinetics of meloxicam in domestic hens and duration and quantity of drug residues in their eggs following PO administration of a single dose (1 mg of meloxicam/kg). ANIMALS 8 healthy adult White Leghorn hens. PROCEDURES Hens were administered 1 mg of meloxicam/kg PO once. A blood sample was collected immediately before and at intervals up to 48 hours after drug administration. The hens' eggs were collected for 3 weeks after drug administration. Samples of the hens' plasma, egg whites (albumen), and egg yolks were analyzed by high-performance liquid chromatography...
August 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28729837/optimization-and-in-vivo-profiling-of-a-refined-rat-model-of-walker-256-breast-cancer-cell-induced-bone-pain-using-behavioral-radiological-histological-immunohistochemical-and-pharmacological-methods
#4
Priyank Shenoy, Andy Kuo, Irina Vetter, Maree T Smith
In the majority of patients with advanced breast cancer, there is metastatic spread to bones resulting in pain. Clinically available drug treatments for alleviation of breast cancer-induced bone pain (BCIBP) often produce inadequate pain relief due to dose-limiting side-effects. A major impediment to the discovery of novel well-tolerated analgesic agents for the relief of pain due to bony metastases is the fact that most cancer-induced bone pain models in rodents relied on the systemic injection of cancer cells, causing widespread formation of cancer metastases and poor general animal health...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28682644/assessing-analgesia-equivalence-and-appetite-following-alfaxalone-or-ketamine-based-injectable-anesthesia-for-feline-castration-as-an-example-of-enhanced-recovery-after-surgery
#5
Tatum Armstrong, Marika C Wagner, Jagjit Cheema, Daniel Sj Pang
Objectives The primary study objective was to assess two injectable anesthetic protocols, given to facilitate castration surgery in cats, for equivalence in terms of postoperative analgesia. A secondary objective was to evaluate postoperative eating behavior. Methods Male cats presented to a local clinic were randomly assigned to receive either intramuscular ketamine (5 mg/kg, n = 26; KetHD) or alfaxalone (2 mg/kg, n = 24; AlfHD) in combination with dexmedetomidine (25 μg/kg) and hydromorphone (0.05 mg/kg)...
February 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28657605/pharmacological-modulation-of-radiation-damage-does-it-exist-a-chance-for-other-substances-than-hematopoietic-growth-factors-and-cytokines
#6
REVIEW
Michal Hofer, Zuzana Hoferová, Martin Falk
In recent times, cytokines and hematopoietic growth factors have been at the center of attention for many researchers trying to establish pharmacological therapeutic procedures for the treatment of radiation accident victims. Two granulocyte colony-stimulating factor-based radiation countermeasures have been approved for the treatment of the hematopoietic acute radiation syndrome. However, at the same time, many different substances with varying effects have been tested in animal studies as potential radioprotectors and mitigators of radiation damage...
June 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28654094/inflammation-and-vascular-remodeling-in-the-ventral-hippocampus-contributes-to-vulnerability-to-stress
#7
J Pearson-Leary, D Eacret, R Chen, H Takano, B Nicholas, S Bhatnagar
During exposure to chronic stress, some individuals engage in active coping behaviors that promote resiliency to stress. Other individuals engage in passive coping that is associated with vulnerability to stress and with anxiety and depression. In an effort to identify novel molecular mechanisms that underlie vulnerability or resilience to stress, we used nonbiased analyses of microRNAs in the ventral hippocampus (vHPC) to identify those miRNAs differentially expressed in active (long-latency (LL)/resilient) or passive (short-latency (SL)/vulnerable) rats following chronic social defeat...
June 27, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28649064/formulation-and-dissolution-enhancement-of-meloxicam-tablets-using-polyvinyl-caprolactam-polyvinyl-acetate-polyethylene-glycol-graft-copolymer-and-povidone-in-combination
#8
Rabia Noor, S M Farid Hasan, Fouzia Hassan, Attique Rehman
Meloxicam is a poor water soluble drug mostly prescribed in various rheumatic diseases. The present research study was design to formulate and increase the solubility of meloxicam in the tablet dosage form. A 3(2) full factorial design was employed to optimize meloxicam formulations. Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (PVCL-PVA-PEG graft copolymer) and Povidone were taken as independent variables while cumulative drug release at 90 minutes was selected as dependent variable...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28644089/evaluation-of-high-dosages-of-oral-meloxicam-in-american-kestrels-falco-sparverius
#9
Noémie M Summa, David Sanchez-Migallon Guzman, Sylvain Larrat, Eric Troncy, David M Bird, Stéphane Lair, Guy Fitzgerald
To evaluate the toxicity of short-term high doses of meloxicam in American kestrels ( Falco sparverius ), 32 male captive-born, 1- to 4-year-old American kestrels were randomly assigned to 4 groups: 3 groups treated with meloxicam (n = 9 per group) and a control group (n = 5). Meloxicam was administered orally via feeding tube in the proventriculus at 2, 10, and 20 mg/kg every 12 hours for 7 days for the treatment groups, while the control group received saline solution. The birds were evaluated for the presence of clinical signs, abnormalities in the complete blood cell count and in the plasma biochemical panel for the 20-mg/kg group, and gross and histopathologic lesions...
June 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28623711/contribution-of-dopaminergic-and-noradrenergic-systems-in-the-antinociceptive-effect-of-%C3%AE-phenylalanyl-acetophenone
#10
Fernanda S S Sousa, Roberta G Anversa, Paloma T Birmann, Maurice N de Souza, Renata Balaguez, Diego Alves, Cristiane Luchese, Ethel A Wilhelm, Lucielli Savegnago
BACKGROUND: This study evaluated the antinociceptive action of α-(phenylalanyl) acetophenone (PSAP) in mice. METHODS: Evaluated whether the serotonergic, adrenergic and dopaminergic systems are involved in PSAP antinociceptive activity. PSAP was administered intragastrically (ig) 30min prior to formalin or glutamate test and compared with a standard drug, meloxicam (10mg/kg, ig). RESULTS: The treatment with PSAP (10-50mg/kg) caused inhibition in the neurogenic phase and reduced the paw oedema caused by intraplantar (ipl) injection of formalin...
March 27, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28618987/synthesis-of-new-thiazolyl-coupled-pyrazoles-bearing-2-4-thiazolidinedionyl-pharmacophore-and-their-anti-inflammatory-and-antibacterial-evaluation
#11
Lalit Khillare, Manisha Bhosle, Mahendra Bhalerao, Kiran Kharat, Ramrao Mane
BACKGROUND: 2, 4-Thiazolidinedione (TZD), pyrazole and thiazole heterocyclic rings exhibit wide range of pharmacological activities. Medicinal chemists use these heterocyclic moieties as scaffolds in drug designing and discovery. The existing medicaments, celecoxib and meloxicam, used for treating inflammation and pain are having, pyrazole and thiazole, respectively as a key scaffolds. Pyrazoles coupled with 2, 4-thiazolidinediones may display enhanced anti inflammatory activity. With this hope the title work was carried...
June 16, 2017: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28609439/interventions-for-treating-patients-with-chikungunya-virus-infection-related-rheumatic-and-musculoskeletal-disorders-a-systematic-review
#12
Arturo Martí-Carvajal, Pilar Ramon-Pardo, Emilie Javelle, Fabrice Simon, Sylvain Aldighieri, Hacsi Horvath, Julia Rodriguez-Abreu, Ludovic Reveiz
BACKGROUND: Chikungunya virus infection (CHIKV) is caused by a mosquito-borne alphavirus. CHIKV causes high fever and painful rheumatic disorders that may persist for years. Because little is known about interventions for treating CHIKV-related illness, we conducted a systematic review. METHODS: We used Cochrane methods. We searched PubMed, EMBASE, Cochrane Library, LILACS and other sources from the earliest records to March 2016. We had no language restrictions...
2017: PloS One
https://www.readbyqxmd.com/read/28601204/battlefield-analgesia-in-tactical-combat-casualty-care
#13
REVIEW
Ian S Wedmore, Frank K Butler
At the start of the Afghanistan conflict, battlefield analgesia for US military casualties was achieved primarily through the use of intramuscular (IM) morphine. This is a suboptimal choice, since IM morphine is slow-acting, leading to delays in effective pain relief and the risk of overdose and death when dosing is repeated in order to hasten the onset of analgesia. Advances in battlefield analgesia, pioneered initially by Tactical Combat Casualty Care (TCCC), and the Army's 75th Ranger Regiment, have now been incorporated into the Triple-Option Analgesia approach...
June 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28597983/celecoxib-for-rheumatoid-arthritis
#14
REVIEW
Mahir Fidahic, Antonia Jelicic Kadic, Mislav Radic, Livia Puljak
BACKGROUND: Rheumatoid arthritis is a systemic auto-immune disorder that causes widespread and persistent inflammation of the synovial lining of joints and tendon sheaths. Presently, there is no cure for rheumatoid arthritis and treatment focuses on managing symptoms such as pain, stiffness and mobility, with the aim of achieving stable remission and improving mobility. Celecoxib is a selective non-steroidal anti-inflammatory drug (NSAID) used for treatment of people with rheumatoid arthritis...
June 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28588338/successful-treatment-of-blastomycosis-in-a-7-year-old-female-golden-retriever-dog-on-manitoulin-island-ontario
#15
Rachael K Needles
A 7-year-old female golden retriever dog was presented with a 2-week history of coughing and inappetence. Examination, radiographs, and blood analysis showed classic evidence of blastomycosis, confirmed with the MVista EIA urine antigen test. A 2-month course of itraconazole and a course of mirtazapine, meloxicam, furosemide, and tetracycline resulted in a successful outcome.
June 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28587132/anti-inflammatory-activity-of-a-polymeric-proanthocyanidin-from-serjania-schiedeana
#16
David Osvaldo Salinas-Sánchez, Enrique Jiménez-Ferrer, Veronica Sánchez-Sánchez, Alejandro Zamilpa, Manasés González-Cortazar, Jaime Tortoriello, Maribel Herrera-Ruiz
The ethyl acetate extract (SsAcOEt) from Serjania schiedeana, select fractions (F-6, F-12, F-13, F-14), and one isolated compound, were evaluated in 12-O-tetradecanoylphorbol 13-acetate (TPA) ear edema and kaolin/carrageenan (KC)-induced monoarthritis assays. SsEtOAc induced edema inhibition of 90% (2.0 mg/ear), fractions showed activity within a range of 67-89%. Due to the fact F-14 showed the highest effect, it was separated, yielding a proanthocyanidin-type called epicatechin-(4β → 8)-epicatechin-(4β → 8, 2β → O → 7) epicatechin (ETP)...
May 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28562037/computational-discovery-and-experimental-validation-of-inhibitors-of-the-human-intestinal-transporter-oatp2b1
#17
Natalia Khuri, Arik A Zur, Matthias B Wittwer, Lawrence Lin, Sook Wah Yee, Andrej Sali, Kathleen M Giacomini
Human organic anion transporters (OATPs) are vital for the uptake and efflux of drugs and endogenous compounds. Current identification of inhibitors of these transporters is based on experimental screening. Virtual screening remains a challenge due to a lack of experimental three-dimensional protein structures. Here, we describe a workflow to identify inhibitors of the OATP2B1 transporter in the DrugBank library of over 5,000 drugs and druglike molecules. OATP member 2B1 transporter is highly expressed in the intestine, where it participates in oral absorption of drugs...
June 15, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28551427/amorphous-solid-dispersion-of-meloxicam-enhanced-oral-absorption-in-rats-with-impaired-gastric-motility
#18
Hiroki Suzuki, Keisuke Yakushiji, Saori Matsunaga, Yukinori Yamauchi, Yoshiki Seto, Hideyuki Sato, Satomi Onoue
Meloxicam (MEL) shows a slow onset of action in severe pain patients due to delayed gastric motility. This study aimed to develop an amorphous solid dispersion (ASD) of MEL to achieve rapid oral absorption in severe pain patients. ASD formulations of MEL with hydroxypropylmethylcellulose (ASD-MEL/HPMC) and polyacrylates and polymethacrylates (ASD-MEL/EUD) were prepared and physicochemically characterized. Oral absorption behavior of MEL samples was also clarified in both normal and propantheline (PPT)-pretreated rats with impaired gastric motility...
May 24, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28551190/clinical-trial-of-local-anesthetic-protocols-for-acute-pain-associated-with-caustic-paste-disbudding-in-dairy-calves
#19
Charlotte B Winder, Stephen J LeBlanc, Derek B Haley, Kerry D Lissemore, M Ann Godkin, Todd F Duffield
Caustic paste disbudding is becoming more commonplace in North America. A large body of work has examined pain control for cautery disbudding and surgical dehorning, but fewer studies have evaluated pain control for caustic paste disbudding, and results conflict regarding benefits of local anesthesia. In humans, the pain associated with a caustic, chemical burn can differ in nature, duration, and intensity compared with a thermal burn. The objective of this clinical trial was to evaluate the effects of either a lidocaine cornual nerve block or a topical anesthetic incorporated into caustic paste on the acute pain of caustic paste disbudding...
May 24, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28532266/soft-chewable-gelatin-based-pharmaceutical-oral-formulations-a-technical-approach
#20
Morten J Dille, Magnus N Hattrem, Kurt I Draget
OBJECTIVE: Hard tablets and capsules for oral drug delivery cause problems for people experiencing dysphagia. The present work describes the formulation and properties of a gelatin based, self-preserved and soft chewable tablet as an alternative and novel drug delivery format. MATERIALS AND METHODS: Gelatin (8.8-10% in 24.7-29% water) constituted the matrix of the soft, semi-solid tablets. Three different pharmaceuticals (Ibuprofen 10%, Acetaminophen 15%, Meloxicam 1...
May 22, 2017: Pharmaceutical Development and Technology
keyword
keyword
107580
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"