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Jianmin Chen, Weiyue Huang, Ziyao Huang, Shiqi Liu, Yaling Ye, Qinglian Li, Meiping Huang
Dissolving microneedles (MNs) offered a simple, minimally invasive method for meloxicam (MX) delivery to the skin. However, the fabrication of dissolving MNs still faced some challenges, such as significant time consumption, loss of drug activity, and difficulty in regulating MN drug loading. To address these issues, we developed the tip-dissolving (TD) MNs. Several kinds of drugs were encapsulated successfully, and the quantity of MX ranged from 37.23 ± 8.40 to 332.53 ± 13.37 μg was precisely controlled...
December 7, 2017: AAPS PharmSciTech
Jennifer Lofgren, Amy L Miller, Claudia Chui Shan Lee, Carla Bradshaw, Paul Flecknell, Johnny Roughan
Murine orthotopic cancer models often require surgery, potentially causing pain or distress. However, analgesics are often withheld because they may alter tumour development. Two orthotopically implanted cancers were investigated in mice pre-treated with meloxicam (10 mg/kg), buprenorphine (0.2 mg/kg) or saline (1 ml/kg). Tumours were imaged and welfare was assessed using body weight, behaviour and nociceptive responses. In study 1, BALB/c mice were inoculated with 4T1 mammary carcinoma or saline during surgery or anaesthesia...
January 1, 2017: Laboratory Animals
H Sano, K Barker, T Odom, K Lewis, P Giordano, V Walsh, J P Chambers
AIMS: To survey current anaesthesia practices for dogs and cats in small and mixed animal practices in New Zealand in order to improve anaesthesia education. METHODS: A questionnaire was sent to 440 small and mixed animal practices, including questions regarding the type of practice, preanaesthetic examination, anaesthetic drugs and management, anaesthetic machines, monitoring and topics of interest for continuing professional development. RESULTS: Responses were obtained from 113/440 (26%) practices, with 78 (69%) respondents from small and 35 (31%) from mixed animal practices...
December 5, 2017: New Zealand Veterinary Journal
John Busby, Liam Murray, Ken Mills, Shu-Dong Zhang, Fabio Liberante, Chris R Cardwell
PURPOSE: We applied a novel combined connectivity mapping and pharmacoepidemiological approach to identify medications that alter breast cancer risk. METHODS: The connectivity mapping process identified 6 potentially cancer-causing (meloxicam, azithromycin, rizatriptan, citalopram, rosiglitazone, and verapamil) and 4 potentially cancer-preventing (bendroflumethiazide, sertraline, fluvastatin, and budesonide) medications that were suitable for pharmacoepidemiological investigation...
December 4, 2017: Pharmacoepidemiology and Drug Safety
Sonia Iurian, Elena Dinte, Cristina Iuga, Cătălina Bogdan, Iuliana Spiridon, Lucian Barbu-Tudoran, Andreea Bodoki, Ioan Tomuţă, Sorin E Leucuţa
The aim of the present study was to evaluate the funtion of fenugreek seed mucilage (FSM) as potential matrix forming agent for orodispersible pharmaceutical lyophilisates. The FSM was isolated and characterized. FSM colloidal dispersions were prepared and the rheological evaluation was performed. Oral lyophilisates (OLs) with different FSM concentrations, containing meloxicam as model drug were prepared by freeze drying method. The OLs were characterized and compared to gelatin containing tablets, prepared under the same conditions...
December 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Joseph L Goulet, Eugenia Buta, Matthew Brennan, Alicia Heapy, Liana Fraenkel
BACKGROUND: Knee osteoarthritis (OA) is the most common cause of knee pain in older adults. Despite the limited data supporting their use, non-steroidal anti-inflammatory drugs (NSAID) are among the most commonly prescribed medications for knee OA. The use of NSAIDs for knee pain warrants careful examination because of toxicity associated with this class of medications. METHODS: We describe the design of a placebo-controlled, noninferiority, randomized withdrawal trial to examine discontinuation of an NSAID in patients with painful knee OA...
November 30, 2017: Contemporary Clinical Trials
Chan Jin, Chenyao Zhao, Dachao Shen, Wenxiang Dong, Hongzhuo Liu, Zhonggui He
OBJECTIVES: The aim of the study was to assess the impact of the differences in dissolution profiles of meloxicam tablets on the in-vivo bioavailability parameters after oral administration. METHODS: Compare in-vitro dissolution testing in the recommended media to evaluate in-vivo bioequivalence outcomes for the Biopharmaceutics Classification System Class II weak acidic drugs. Nine Beagle dogs received a single oral administration of each formulation (7.5 mg) in a three-way crossover design...
November 28, 2017: Journal of Pharmacy and Pharmacology
Sarah F Capik, Brad J White, Robert L Larson, Nicholas Van Engen, Natalia Cernicchiaro, Terry J Engelken, Jeffrey Lakritz, Michael A Ballou, Lindsey E Hulbert, Rhonda C Vann, Jeff L Caswell, Gabriella Jacob, Jeffery A Carroll, Johann F Coetzee
OBJECTIVE To investigate the effects of meloxicam administration before long-distance transport on inflammatory mediators and leukocyte function of cattle at feedlot arrival. ANIMALS 60 healthy yearling beef steers. PROCEDURES Single-source steers were assigned to a transported (n = 40) or nontransported (20) group. Then, half of the steers within each group were assigned to receive meloxicam (1 mg/kg, PO) or a lactose placebo (1 bolus/steer, PO). All steers were transported approximately 1,300 km overnight to a feedlot; however, the nontransported group was moved before treatment (meloxicam or placebo) administration and allowed a 17-day acclimation period, whereas the transported group was moved immediately after treatment administration on day -1...
December 2017: American Journal of Veterinary Research
Sarah F Capik, Brad J White, Robert L Larson, Nicholas Van Engen, Johann F Coetzee
OBJECTIVE To evaluate the effects of meloxicam on movement, feeding, and drinking behaviors of transported and nontransported cattle. ANIMALS 100 crossbred beef steers. PROCEDURES During experiment 1 of a 2-experiment study, calves from a livestock auction received meloxicam (1 mg/kg, PO; n = 50) or a lactose placebo (1 capsule/calf; 50; control), then calves were transported approximately 1,000 km overnight to a feedlot, where they were instrumented with a real-time location-monitoring ear tag, placed in randomly assigned pens (n = 5 pens/treatment), and monitored for 21 days...
December 2017: American Journal of Veterinary Research
Qikun Jiang, Jin Wang, Panqin Ma, Cuiru Liu, Mengchi Sun, Yinghua Sun, Zhonggui He
The aim of the study was to develop a novel drug-in-adhesive patch for transdermal delivery of meloxicam (MLX). The formulation involved a strategy to combine a chemical enhancer with an ion-pair agent. Diethylamine (DETA) was selected as the counter ion to form the ion-pair agent MLX-DETA. MLX-DETA was characterized by nuclear magnetic resonance spectroscopy (NMR) and Fourier transform infrared spectroscopy (FTIR). The ion-pair lifetime (T life) of MLX-DETA was 164.1 μs. The water solubility of MLX-DETA was increased nearly 9...
November 27, 2017: Drug Delivery and Translational Research
Pengfei She, Yangxia Wang, Zhen Luo, Lihua Chen, Ruichen Tan, Yanle Wang, Yong Wu
Microbial biofilms are communities of surface-adhered cells enclosed in a matrix of extracellular polymeric substances. Bacterial cells in biofilm are 10~1,000-fold more resistant to antimicrobials than the planktonic cells. Burgeoning antibiotic resistance in Pseudomonas aeruginosa biofilm has necessitated the development of antimicrobial agents. Here, we have investigated the antibiofilm effect of meloxicam against P. aeruginosaPAO1 and its potential mechanisms. Further, we have explored whether meloxicam could enhance the susceptibility of bacterial biofilms to treatment with conventional antimicrobials...
November 27, 2017: MicrobiologyOpen
Lucas Melo da Silveira, Ariadne Botto Fiorot, Thiago Padovani Xavier, Maria Irene Yoshida, Marcelo Antonio de Oliveira
Meloxicam (MLX) is a non-steroidal anti-inflammatory cyclooxygenase (COX) inhibitor that is used to relieve inflammation and pain. MLX has a preferential affinity for COX-2, which is associated with a lower incidence of gastrointestinal side effects. The drug belongs to Class II of the Biopharmaceutical Classification System (BCS) in which dissolution is the limiting step of its bioavailability. In view of this classification, carrying out further studies regarding the compatibility of MLX with excipients and the mechanisms and kinetics of its degradation reactions is fundamental because any changes would directly influence the quality of the product...
November 22, 2017: European Journal of Pharmaceutical Sciences
Heidi S Lehmann, Gabrielle C Musk, Michael Laurence, Timothy H Hyndman, Jonathan Tuke, Teresa Collins, Karina B Gleerup, Craig B Johnson
OBJECTIVE: To investigate the mitigating effects of administration of local or systemic meloxicam on the electroencephalographic (EEG) and cardiovascular responses during surgical castration of Bos indicus bull calves. STUDY DESIGN: Prospective, randomized, experimental study. ANIMALS: Thirty-six 6-8 month-old Bos indicus bull calves, with a mean ± standard deviation weight of 237 ± 19 kg. METHODS: Animals were allocated randomly to three groups of 12 (group L, 260 mg of 2% lidocaine subcutaneously and intratesticularly 5 minutes prior to castration; group M, 0...
August 24, 2017: Veterinary Anaesthesia and Analgesia
Tomasz Osmalek, Anna Froelich, Barbara Jadach, Katarzyna Ancukiewicz, Piotr Gadzinski
The objective of the presented work was to formulate and investigate the rheological behavior of non-aqueous gels containing 0.5% of meloxicam (MLX) in a non-ionic, dissolved form. Fumed silica and SynperonicTM PE/L 62 were used as structure forming components. Arlasolve®, Transcutol®, ethanol and DMSO were applied as solubilizers and potential skin absorption enhancers. In the first step, the preformulation studies were conducted in order to optimize the composition of the vehicle. The main acceptance criterion was the ability of the medium to dissolve MLX, which was confirmed by the lack of drug crystals and proper clarity of the formulation...
November 20, 2017: Current Drug Delivery
Odd V Höglund, Barbara Dyall, Victoria Gräsman, Anna Edner, Ulf Olsson, Katja Höglund
Objectives The use of physiological parameters such as respiratory rate and heart rate to assess pain has long been discussed. The aim of the study was to compare postoperative respiratory rate and heart rate in cats subjected to flank ovariohysterectomy treated with a preoperative non-steroidal anti-inflammatory drug (NSAID) or no NSAID, and determine whether these parameters are suitable for postoperative pain assessment in cats. We hypothesised that cats without an NSAID would experience more postoperative pain, which may increase heart rate and respiratory rate...
November 1, 2017: Journal of Feline Medicine and Surgery
Juan J Jiménez, Beatriz E Muñoz, María I Sánchez, Rafael Pardo
The fate of the pharmaceutical drugs tenoxicam, piroxicam and meloxicam in river water is evaluated here for first time. So, biological, photochemical and thermal degradation assays have been conducted to estimate their degradation rates and know their degradation products. Results indicated that the direct sunlight irradiation, without any protection, promoted a fast degradation of the oxicams while the chemical reactions in solution were less important. The biological degradation in water was negligible except for tenoxicam in whose case its influence was scarce...
October 25, 2017: Chemosphere
Henri Gmj Bertrand, Charlotte Sandersen, Paul A Flecknell
Volatile agents are widely used to anaesthetise laboratory non-human primates as they allow a rapid induction and recovery as well as an easy adjustment of the anaesthesia plan. Desflurane is currently the volatile agent with the lowest solubility in blood, and hence enables the most rapid onset of anaesthesia and most rapid recovery. This study aimed to investigate the suitability of desflurane for maintenance of general anaesthesia in rhesus macaques undergoing elective experimental neurosurgery. Fourteen primates (five males and nine females) were sedated with ketamine (10 mg kg(-1)) and anaesthesia was induced with propofol (usually 8 mg kg(-1) IV)...
January 1, 2017: Laboratory Animals
Wipada Samprasit, Prasert Akkaramongkolporn, Ruchadaporn Kaomongkolgit, Praneet Opanasopit
This work deals with fast-dissolving drug delivery systems of meloxicam (MX) derived from electrospun polyvinylpyrrolidone (PVP)/2-hydroxypropyl-β-cyclodextrin (HPβCD) nanofiber mats. Electrospinning of solutions with different solvent systems (dimethylformamide (DMF) and ethyl alcohol (EtOH)) was performed. Prepared films were evaluated for morphology, physical and mechanical properties. MX content, dissolving time, MX release, and cytotoxicity of films were investigated. In vivo studies were also performed in healthy human volunteers...
November 6, 2017: Pharmaceutical Development and Technology
Carolina Quarterone, Stelio Pacca Loureiro Luna, Nadia Crosignani, Flávia Augusta de Oliveira, Carlize Lopes, Alfredo Feio da Maia Lima, Antonio Jose de Araújo Aguiar
The requirement for post-operative analgesia after ovariohysterectomy (OH) versus orchiectomy in dogs and cats was compared. Twelve male and 12 female cats and 12 male and 12 female dogs received meloxicam, 0.1 mg/kg body weight, PO, 2 h before surgery. Eleven female cats and 3 female dogs received rescue analgesia (P = 0.002). No male of either species required rescue analgesia. The number of cats receiving rescue analgesia was greater in females than in males (P < 0.0001). One should not rely solely on preoperative short-acting opioid and preemptive use of NSAIDs to control postoperative pain following OH, in dogs or cats...
November 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
Petra Cagnardi, Jacopo Guccione, Roberto Villa, Luigi D'Andrea, Antonio Di Loria, Maria Carmela Ferrante, Giuliano Borriello, Luigi Zicarelli, Paolo Ciaramella
The aims of the investigation were to establish for the first time (i) clinical efficacy and (ii) pharmacokinetic profile of meloxicam intravenously (IV) administered in male Mediterranean buffalo calves after surgical orchiectomy. The study was performed on 10 healthy buffalo calves, between 4 and 5 months old and between 127 and 135 kg of body weight (b.w.). An IV injection of 0.5 mg/kg b.w. of meloxicam was administered in six calves (treated group, TG) immediately after surgery; the other four animals were used as untreated control group (CG)...
2017: PloS One
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