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https://www.readbyqxmd.com/read/28212127/surgical-management-of-mandibular-intraosseous-schwannomas
#1
Anthony DeLeonibus, Bahar Bassiri Gharb, Francis Papay, James E Zins, Antonio Rampazzo
Intraosseous schwannomas of the mandible are rare tumors that usually arise from peripheral nerve sheaths of the main trunk or branches of the inferior alveolar nerve (IAN).A systematic review of the English literature through PubMed was conducted from 1945 to 2016. Forty-nine patients of mandibular intraosseous schwannomas were identified. The most common location of the tumor was the posterior mandible (61.2%). There were 28 patients in whom the tumor involved the IAN (57.1%). The most commonly performed procedures included enucleation through a mucoperiosteal flap and a bone window (73%), curettage (10%), segmental mandibulectomy (10%), and sagittal split ramus osteotomy (6%)...
February 16, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28198602/the-profile-of-upper-extremity-muscular-strength-in-female-wheelchair-basketball-players-a-pilot-study
#2
Bahar Külünkoğlu, Yasemin Akkubak, Nevin Ergun
BACKGROUND: The purpose of this study was to analyze and compare the profile of upper extremity muscle strength in female wheelchair basketball players with that of sex-matched non-disabled controls. METHODS: Nineteen female subjects were enrolled in this study. These were divided into two groups. Group 1 (n=10) consisted of wheelchair basketball players and Group 2 (n=9) of non-disabled individuals. Muscular strength in the shoulder was measured using an isokinetic dynamometer...
February 14, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28195087/perineural-invasion-is-a-valuable-prognostic-factor-in-advanced-stage-and-or-node-cervical-cancer
#3
Cigdem Vural, Busra Yaprak Bayrak, Bahar Muezzınoglu, Izzet Yucesoy
BACKGROUND: Perineural invasion (PNI) is correlated with adverse survival in several malignancies, but its significance cervical cancer remains to be clearly defined. The objective of this study was to determine the association between PNI status and clinical outcomes in clinically localized surgically treated cervical cancers. MATERIALS AND METHODS: We reviewed clinical records and pathology slides of 111 patients with cervical cancer treated with surgery at a single academic center...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28188566/review-of-the-physics-of-living-systems-by-fabrizio-cleri-springer-2016-620-pp-isbn-978-3-319-30645-2
#4
Sonya Bahar
No abstract text is available yet for this article.
February 11, 2017: Journal of Biological Physics
https://www.readbyqxmd.com/read/28187360/de-novo-assembly-of-the-ringed-seal-pusa-hispida-blubber-transcriptome-a-tool-that-enables-identification-of-molecular-health-indicators-associated-with-pcb-exposure
#5
Tanya M Brown, S Austin Hammond, Bahar Behsaz, Nik Veldhoen, Inanç Birol, Caren C Helbing
The ringed seal, Pusa hispida, is a keystone species in the Arctic marine ecosystem, and is proving a useful marine mammal for linking polychlorinated biphenyl (PCB) exposure to toxic injury. We report here the first de novo assembled transcriptome for the ringed seal (342,863 transcripts, of which 53% were annotated), which we then applied to a population of ringed seals exposed to a local PCB source in Arctic Labrador, Canada. We found an indication of energy metabolism imbalance in local ringed seals (n=4), and identified five significant gene transcript targets: plasminogen receptor (Plg-R(KT)), solute carrier family 25 member 43 receptor (Slc25a43), ankyrin repeat domain-containing protein 26-like receptor (Ankrd26), HIS30 (not yet annotated) and HIS16 (not yet annotated) that may represent indicators of PCB exposure and effects in marine mammals...
February 3, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28183735/new-insights-into-the-regulatory-function-of-cyfip1-in-the-context-of-wave-and-fmrp-containing-complexes
#6
Sabiha Abekhoukh, H Bahar Sahin, Mauro Grossi, Samantha Zongaro, Thomas Maurin, Irene Madrigal, Daniele Kazue-Sugioka, Annick Raas-Rothschild, Mohamed Doulazmi, Pilar Carrera, Andrea Stachon, Steven Scherer, Maria Rita Drula Do Nascimento, Alain Trembleau, Ignacio Arroyo, Szatmari Peter, Isabel M Smith, Montserrat Milà, Adam C Smith, Angela Giangrande, Isabelle Caillé, Barbara Bardoni
CYtoplasmic FMRP Interacting Protein 1 (CYFIP1) is a candidate gene for intellectual disability (ID), autism, schizophrenia and epilepsy. It is a member of a family of proteins that is very conserved during evolution, sharing high homology with dCYFIP, its Drosophila homolog. CYFIP1 interacts with the Fragile X Mental Retardation Protein (FMRP), whose absence causes the Fragile X Syndrome, and with the translation initiation factor eIF4E. It is a member of the WAVE Regulatory Complex (WRC), thus representing a link between translational regulation and actin cytoskeleton...
February 9, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28182578/review-of-heavy-metal-accumulation-on-aquatic-environment-in-northern-east-mediterrenean-sea-part-i-some-essential-metals
#7
Ayşe Bahar Yılmaz, Alper Yanar, Ela Nur Alkan
All pollutants can reach the aquatic environments and the levels of heavy metals in upper members of the food web like fish can reach values many times higher than those found in aquatic environment or in sediments. Although heavy metals are essential or non-essential, all heavy metals are potentially harmful to humans and most organisms at some level of exposure and absorption. Marine organisms are good indicators for long-term monitoring of metal accumulation. The present review study is for evaluation of the data from previous studies about the toxic effects of selected heavy metals, like essential metals (copper, zinc, iron, chromium, and manganese), on seawater, sediment, and in different tissues of aquatic animals (demersal and bentic fish, invertabres) collected from different areas in Northern East Mediterrenean Sea since the 1990s...
February 9, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28179529/differential-disruption-of-nucleocytoplasmic-trafficking-pathways-by-rhinovirus-2a-proteases
#8
Kelly Watters, Bahar Inankur, Jaye C Gardiner, Jay Warrick, Nathan M Sherer, John Yin, Ann C Palmenberg
The RNA rhinoviruses (RV) encode 2A proteases (2A(pro)) that contribute essential polyprotein processing and host-cell shutoff functions during infection, including the cleavage of Phe/Gly-containing nucleoporin proteins (Nups) within nuclear pore complexes (NPC). Within the 3 RV species, multiple divergent genotypes encode diverse 2A(pro) sequences which act differentially on specific Nups. Since only subsets of Phe/Gly motifs, particularly those within Nup62, Nup98 and Nup153, are recognized by transport receptors (karyopherins) when trafficking large molecular cargos through the NPC, the processing preferences of individual 2A(pro) predict RV genotype-specific targeting of NPC pathways and cargos...
February 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28167941/nr4a-receptors-differentially-regulate-nf-%C3%AE%C2%BAb-signaling-in-myeloid-cells
#9
Caitriona McEvoy, Monica de Gaetano, Hugh E Giffney, Bojlul Bahar, Eoin P Cummins, Eoin P Brennan, Mary Barry, Orina Belton, Catherine G Godson, Evelyn P Murphy, Daniel Crean
Dysregulation of inflammatory responses is a hallmark of multiple diseases such as atherosclerosis and rheumatoid arthritis. As constitutively active transcription factors, NR4A nuclear receptors function to control the magnitude of inflammatory responses and in chronic inflammatory disease can be protective or pathogenic. Within this study, we demonstrate that TLR4 stimulation using the endotoxin lipopolysaccharide (LPS) rapidly enhances NR4A1-3 expression in human and murine, primary and immortalized myeloid cells with concomitant gene transcription and protein secretion of MIP-3α, a central chemokine implicated in numerous pathologies...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28166538/single-cell-spatial-reconstruction-reveals-global-division-of-labour-in-the-mammalian-liver
#10
Keren Bahar Halpern, Rom Shenhav, Orit Matcovitch-Natan, Beáta Tóth, Doron Lemze, Matan Golan, Efi E Massasa, Shaked Baydatch, Shanie Landen, Andreas E Moor, Alexander Brandis, Amir Giladi, Avigail Stokar-Avihail, Eyal David, Ido Amit, Shalev Itzkovitz
The mammalian liver consists of hexagon-shaped lobules that are radially polarized by blood flow and morphogens. Key liver genes have been shown to be differentially expressed along the lobule axis, a phenomenon termed zonation, but a detailed genome-wide reconstruction of this spatial division of labour has not been achieved. Here we measure the entire transcriptome of thousands of mouse liver cells and infer their lobule coordinates on the basis of a panel of zonated landmark genes, characterized with single-molecule fluorescence in situ hybridization...
February 6, 2017: Nature
https://www.readbyqxmd.com/read/28166396/elmo3-predicts-poor-outcome-in-t1-laryngeal-cancer
#11
Georg Haymerle, Lorenz Kadletz, Robert Wiebringhaus, Bahar Golabi, Michael Mildner, Dietmar Thurnher, Gregor Heiduschka
OBJECTIVES: Despite the excellent overall survival of 92-97% in early glottic cancer, recurrence rates of 13-20% have not improved in the last decades. The engulfment and cell motility protein 3 (ELMO3) has been described as prognostic marker in lung cancer patients. The aim of this study was to investigate the expression of ELMO3 in early laryngeal cancer patients treated with TLM and to evaluate its prognostic significance on clinical outcome. DESIGN, SETTING AND PARTICIPANT: 48 patients with glottic carcinoma (T1N0M0) that underwent primary treatment with TLM between 1994 and 2012 were analyzed...
February 6, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28166214/dense-genotyping-of-immune-related-loci-implicates-host-responses-to-microbial-exposure-in-beh%C3%A3-et-s-disease-susceptibility
#12
Masaki Takeuchi, Nobuhisa Mizuki, Akira Meguro, Michael J Ombrello, Yohei Kirino, Colleen Satorius, Julie Le, Mary Blake, Burak Erer, Tatsukata Kawagoe, Duran Ustek, Ilknur Tugal-Tutkun, Emire Seyahi, Yilmaz Ozyazgan, Inês Sousa, Fereydoun Davatchi, Vânia Francisco, Farhad Shahram, Bahar Sadeghi Abdollahi, Abdolhadi Nadji, Niloofar Mojarad Shafiee, Fahmida Ghaderibarmi, Shigeaki Ohno, Atsuhisa Ueda, Yoshiaki Ishigatsubo, Massimo Gadina, Sofia A Oliveira, Ahmet Gül, Daniel L Kastner, Elaine F Remmers
We analyzed 1,900 Turkish Behçet's disease cases and 1,779 controls genotyped with the Immunochip. The most significantly associated SNP was rs1050502, a tag SNP for HLA-B*51. In the Turkish discovery set, we identified three new risk loci, IL1A-IL1B, IRF8, and CEBPB-PTPN1, with genome-wide significance (P < 5 × 10(-8)) by direct genotyping and ADO-EGR2 by imputation. We replicated the ADO-EGR2, IRF8, and CEBPB-PTPN1 loci by genotyping 969 Iranian cases and 826 controls. Imputed data in 608 Japanese cases and 737 controls further replicated ADO-EGR2 and IRF8, and meta-analysis additionally identified RIPK2 and LACC1...
February 6, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28165717/ultrafine-silver-nanoparticles-supported-on-a-conjugated-microporous-polymer-as-high-performance-nanocatalysts-for-nitrophenol-reduction
#13
Hai-Lei Cao, Hai-Bo Huang, Zhi Chen, Bahar Karadeniz, Jian Lü, Rong Cao
A conjugated microporous polymer (CMP) material was designed with pore function of cyano and pyridyl groups that act as potential binding sites for Ag(+) ion capture. Ultrafine silver nanoparticles (less than 5 nm) were successfully supported on the predesigned CMP material to afford Ag(0)@CMP composite materials by means of a simple liquid impregnation and light-induced reduction method. Spherical Ag(0) nanoparticles with a statistical mean diameter of ca. 3.9 nm were observed and characterized by scanning electron microscopy and transmission electron microscopy...
February 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28164130/effects-of-different-pediatric-drugs-on-the-color-stability-of-various-restorative-materials-applicable-in-pediatric-dentistry
#14
Tamer Tüzüner, Sedanur Turgut, Ozgul Baygin, Nagehan Yilmaz, Elif Bahar Tuna, Bugra Ozen
Background. The chronic recommendation of pediatric drugs could exhibit erosive and cariogenic problems. Objective. To evaluate the effects of different pediatric drugs on the color stability of various restorative materials. Methods. Five specimens (1 mm × 3 mm) were prepared and immersed in ten different pediatric drugs and agitated every 8 hours daily for 2 min up to 1 week. Between immersion periods, the samples were stored in artificial saliva. After 1-week period, ΔE(⁎) values were calculated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28155625/ethnic-and-geographical-differences-in-ischaemic-stroke-among-young-adults
#15
Nilufer Yesilot, Jukka Putaala, Sara Zarko Bahar, Turgut Tatlısumak
Ischaemic stroke in young adults encompasses approximately 5 - 15% of all ischaemic strokes, depending on the selected upper age limit. The key features of the disease, including incidence, risk factors, underlying causes, mortality, outcomes, as well as long-term risks of recurrent events are different from those for elderly patients. There is also evidence indicating that these characteristics may differ ethnically and geographically. It is clinically important to recognize such differences not only for correct diagnosis and treatment, but also for introducing accurate preventive measures...
February 2, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28155120/novel-glycoside-from-wedelia-calendulacea-inhibits-diethyl-nitrosamine-induced-renal-cancer-via-downregulating-the-cox-2-and-peg2-through-nuclear-factor-%C3%AE%C2%BAb-pathway
#16
Amita Verma, Bahar Ahmed, Firoz Anwar, Mahfoozur Rahman, Dinesh Kumar Patel, Gaurav Kaithwas, Ravi Rani, Prakash C Bhatt, Vikas Kumar
A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3-O-β-D-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae). The structure was elucidated and established by standard spectroscopy approaches. Diethylnitrosamine (DEN) (200 mg/kg) and ferric nitrilotriacetate (Fe-NTA) (9 mg/kg) were used for induction of renal cell carcinoma (RCC) in the rats. The rats were further divided into different groups and were treated with HEG doses for 22 weeks...
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28146110/polyphenolic-extract-of-euphorbia-supina-attenuates-manganese-induced-neurotoxicity-by-enhancing-antioxidant-activity-through-regulation-of-er-stress-and-er-stress-mediated-apoptosis
#17
Entaz Bahar, Geum-Hwa Lee, Kashi Raj Bhattarai, Hwa-Young Lee, Min-Kyung Choi, Harun-Or Rashid, Ji-Ye Kim, Han-Jung Chae, Hyonok Yoon
Manganese (Mn) is an important trace element present in human body, which acts as an enzyme co-factor or activator in various metabolic reactions. While essential in trace amounts, excess levels of Mn in human brain can produce neurotoxicity, including idiopathic Parkinson's disease (PD)-like extrapyramidal manganism symptoms. This study aimed to investigate the protective role of polyphenolic extract of Euphorbia supina (PPEES) on Mn-induced neurotoxicity and the underlying mechanism in human neuroblastoma SKNMC cells and Sprague-Dawley (SD) male rat brain...
January 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28138106/teratogenicity-of-antiepileptic-drugs
#18
Betül Tekin Güveli, Rasim Özgür Rosti, Alper Güzeltaş, Elif Bahar Tuna, Dilek Ataklı, Serra Sencer, Ensar Yekeler, Hülya Kayserili, Ahmet Dirican, Nerses Bebek, Betül Baykan, Ayşen Gökyiğit, Candan Gürses
Objective: Antiepileptic drugs (AED) have chronic teratogenic effects, the most common of which are congenital heart disease, cleft lip/palate, urogenital and neural tube defects. The aim of our study is to examine teratogenic effects of AED and the correlation between these malformations and AED in single or multiple pregnancies. Methods: This is a retrospective study of malformations in children born to mothers currently followed up by our outpatient clinics who used or discontinued AED during their pregnancy...
February 28, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28127355/evaluating-effect-of-albendazole-on-trichuris-trichiura-infection-a-systematic-review-article
#19
REVIEW
Toraj Ahmadi Jouybari, Khadije Najaf Ghobadi, Bahare Lotfi, Hamid Alavi Majd, Nayeb Ali Ahmadi, Mohammad Rostami-Nejad, Abbas Aghaei
BACKGROUND: The aim of the study was assessment of defaults and conducted meta-analysis of the efficacy of single-dose oral albendazole against T. trichiura infection. METHODS: We searched PubMed, ISI Web of Science, Science Direct, the Cochrane Central Register of Controlled Trials, and WHO library databases between 1983 and 2014. Data from 13 clinical trial articles were used. Each article was included the effect of single oral dose (400 mg) albendazole and placebo in treating two groups of patients with T...
October 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28127326/assessment-of-surface-markers-derived-from-human-periodontal-ligament-stem-cells-an-in-vitro-study
#20
Zainab Kadkhoda, Sahar Chokami Rafiei, Bahare Azizi, Ahad Khoshzaban
OBJECTIVES: Periodontal tissue regeneration for treatment of periodontal disease has not yet been mastered in tissue engineering. Stem cells, scaffold, and growth factors are the three main basic components of tissue engineering. Periodontal ligament (PDL) contains stem cells; however, the number, potency and features of these cells have not yet been understood. This study aimed to isolate and characterize the properties of PDL stem cells. MATERIALS AND METHODS: In this experimental study, samples were isolated from the PDL of extracted teeth of five patients and then stained immunohistochemically for detection of cell surface markers...
September 2016: Journal of Dentistry of Tehran University of Medical Sciences
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