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https://www.readbyqxmd.com/read/29332037/increased-vulnerability-of-the-hippocampus-in-transgenic-mice-overexpressing-app-and-triple-repeat-tau
#1
Andrew Arner, Edward Rockenstein, Michael Mante, Jazmin Florio, Deborah Masliah, Bahar Salehi, Anthony Adame, Cassia Overk, Eliezer Masliah, Robert A Rissman
 Alzheimer's disease (AD) is the most common tauopathy, characterized by progressive accumulation of amyloid-β (Aβ) and hyperphosphorylated tau. While pathology associated with the 4-repeat (4R) tau isoform is more abundant in corticobasal degeneration and progressive supranuclear palsy, both 3R and 4R tau isoforms accumulate in AD. Many studies have investigated interactions between Aβ and 4R tau in double transgenic mice, but few, if any, have examined the effects of Aβ with 3R tau. To examine this relationship, we crossed our APP751 mutant line with our recently characterized 3R tau mutant model to create a bigenic line (hAPP-3RTau) to model AD neuropathology...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29329806/effect-of-different-animal-fat-and-plant-oil-additives-on-physicochemical-mechanical-antimicrobial-and-antioxidant-properties-of-chitosan-films
#2
Lalehan Akyuz, Murat Kaya, Sedef Ilk, Yavuz Selim Cakmak, Asier M Salaberria, Jalel Labidi, Bahar Akyuz Yılmaz, Idris Sargin
Practical application of chitosan-essential oil blend films is limited due to the uneconomical extraction procedure of essential oils from plants. This study aimed to produce chitosan films blended with low cost and commercially available oils and fats consumed in daily human diet (olive, corn and sunflower oils, butter and animal fats). The study also focused on how physicochemical, biological and mechanical properties of chitosan blend films were influenced by the incorporation of oils and fats with varying unsaturation degrees...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329002/integration-of-multi-scale-molecular-modeling-approaches-with-experiments-for-the-in-silico-guided-design-and-discovery-of-novel-herg-neutral-antihypertensive-oxazalone-and-imidazolone-derivatives-and-analysis-of-their-potential-restrictive-effects-on-cell
#3
Serdar Durdagi, Busecan Aksoydan, Ismail Erol, Isik Kantarcioglu, Yavuz Ergun, Gulay Bulut, Melih Acar, Timucin Avsar, George Liapakis, Vlasios Karageorgos, Ramin E Salmas, Barış Sergi, Sara Alkhatib, Gizem Turan, Berfu Nur Yigit, Kutay Cantasir, Bahar Kurt, Turker Kilic
AT1 antagonists is the most recent drug class of molecules against hypertension and they mediate their actions through blocking detrimental effects of angiotensin II (A-II) when acts on type I (AT1) A-II receptor. The effects of AT1 antagonists are not limited to cardiovascular diseases. AT1 receptor blockers may be used as potential anti-cancer agents - due to the inhibition of cell proliferation stimulated by A-II. Therefore, AT1 receptors and the A-II biosynthesis mechanisms are targets for the development of new synthetic drugs and therapeutic treatment of various cardiovascular and other diseases...
December 11, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29325972/antioxidant-activity-of-cape-caffeic-acid-phenethyl-ester-in-vitro-can-protect-human-sperm-deoxyribonucleic-acid-from-oxidative-damage
#4
Şule Ayla, Gülden Tunalı, Bülent E Bilgiç, Kenan Sofuoğlu, A Arman Özdemir, Gamze Tanrıverdi, Semra Özdemir, B Cem Soner, Bahar Öztürk, Serçin Karahüseyinoğlu, Esra Güler Aslan, Ismail Seçkin
PURPOSE: Sperm processing (e.g., centrifugation) used in preparation for assisted reproduction can result in excessive generation of reactive oxygen species (ROS) and potential sperm damage. The use of antioxidants during sperm processing has been shown to prevent iatrogenic sperm damage, including DNA damage. In this study, we evaluated the effect of caffeic acid phenethyl ester (CAPE) on oxidative stress mediated sperm dysfunction and DNA damage. METHODS: Semen samples were obtained to liquefy at room temperature...
January 8, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29321551/aster-leafhopper-survival-and-reproduction-and-aster-yellows-transmission-under-static-and-fluctuating-temperatures-using-ddpcr-for-phytoplasma-quantification
#5
Md H Bahar, Tyler J Wist, Diana R Bekkaoui, Dwayne D Hegedus, Chrystel Y Olivier
Aster yellows (AY) is an important disease of Brassica crops and is caused by Candidatus Phytoplasma asteris and transmitted by the insect vector, Aster leafhopper (Macrosteles quadrilineatus). Phytoplasma-infected Aster leafhoppers were incubated at various constant and fluctuating temperatures ranging from 0 to 35 °C with the reproductive host plant barley (Hordium vulgare). At 0 °C, leafhopper adults survived for 18 days, but failed to reproduce, whereas at 35 °C insects died within 18 days, but successfully reproduced before dying...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317549/appendiceal-mucinous-neoplasms-diagnosis-and-management
#6
Walid L Shaib, Rita Assi, Ali Shamseddine, Olatunji B Alese, Charles Staley, Bahar Memis, Volkan Adsay, Tanios Bekaii-Saab, Bassel F El-Rayes
No abstract text is available yet for this article.
January 2018: Oncologist
https://www.readbyqxmd.com/read/29310365/ebv-lymphoproliferative-associated-disease-and-primary-cardiac-t-cell-lymphoma-in-a-stk4-deficient-patient-a-case-report
#7
Roya Sherkat, Mohammad Reza Sabri, Bahar Dehghan, Hamid Bigdelian, Nahid Reisi, Nooshin Afsharmoghadam, Hamid Rahimi, Narges Rahmanian, Cristoph Klein
RATIONALE: Primary cardiac lymphoma (PLC) is an extremely uncommon malignancy. PCL is more common in secondary immunodeficient patients. In this report, we describe a unique case of PLC who had been diagnosed as a STK4 deficient patient. This case is the first Primary immunodeficiency (PID) patient developing PCL in the world. PATIENT CONCERNS: An eleven-year-old girl, a known case of PID, was referred to the pediatric cardiology department because of chest pain and dyspnea...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29306704/neuroprotective-effect-of-acute-ethanol-intoxication-in-tbi-is-associated-to-the-hierarchical-modulation-of-early-transcriptional-responses
#8
Akila Chandrasekar, Bahar Aksan, Florian Olde Heuvel, Philip Förstner, Daniela Sinske, Rida Rehman, Annette Palmer, Albert Ludolph, Markus Huber-Lang, Tobias Böckers, Daniela Mauceri, Bernd Knöll, Francesco Roselli
Ethanol intoxication is a risk factor for traumatic brain injury (TBI) but clinical evidence suggests that it may actually improve the prognosis of intoxicated TBI patients. We have employed a closed, weight-drop TBI model of different severity (2cm or 3cm falling height), preceded (-30min) or followed (+20min) by ethanol administration (5g/Kg). This protocol allows us to study the interaction of binge ethanol intoxication in TBI, monitoring behavioral changes, histological responses and the transcriptional regulation of a series of activity-regulated genes (immediate early genes, IEGs)...
January 4, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29306234/evaluation-of-ambulatory-arterial-stiffness-index-in-hyperthyroidism
#9
Özlem Turhan İyidir, Mehmet Muhittin Yalçın, Alev Eroğlu Altınova, Emre Arslan, Bahar Uncu, Ceyla Konca Değertekin, Füsun Baloş Törüner
Background/aim: Hyperthyroidism causes hemodynamic changes that are associated with adverse cardiovascular outcomes. Twenty-four-hour ambulatory blood pressure monitoring recordings provide us with some essential data: BP variability and ambulatory arterial stiffness index (AASI). In this study, we aimed to investigate AASI and short-term BP variability in both overt and subclinical hyperthyroidism and their relationship with thyroid hormones. Materials and methods: We enrolled 36 patients with subclinical hyperthyroidism, 23 patients with overt hyperthyroidism, and 25 healthy euthyroid controls...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29305935/hedgehog-yap-signaling-pathway-regulates-glutaminolysis-to-control-hepatic-stellate-cell-activation
#10
Kuo Du, Jeongeun Hyun, Richard T Premont, Steve S Choi, Gregory A Michelotti, Marzena Swiderska-Syn, George D Dalton, Eric Thelen, Bahar Salimian Rizi, Youngmi Jung, Anna Mae Diehl
BACKGROUND & AIMS: Cirrhosis results from accumulation of myofibroblasts derived from quiescent hepatic stellate cells (Q-HSCs); it regresses when myofibroblastic HSCs are depleted. Hedgehog signaling promotes transdifferentiation of HSCs by activating Yes-associated protein 1 (YAP1 or YAP) and inducing aerobic glycolysis. However, increased aerobic glycolysis alone cannot meet the high metabolic demands of myofibroblastic HSCs. Determining the metabolic processes of these cells could lead to strategies to prevent progressive liver fibrosis, so we investigated whether glutaminolysis (conversion of glutamine to alpha-ketoglutarate) sustains energy metabolism and permits anabolism when Q-HSCs become myofibroblastic, and whether this is controlled by hedgehog signaling to YAP...
January 3, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29299933/is-there-any-relationship-between-adc-values-of-diffusion-weighted-imaging-and-the-histopathologic-prognostic-factors-of-invasive-ductal-carcinoma
#11
Hale Aydin, Bahar Guner, Isil Esen Bostanci, Melda Boyacioglu Bulut, Bilgin Kadri Aribas, Lutfi Dogan, Mehmet Ali Gulcelik
OBJECTIVE: Magnetic resonance imaging (MRI) is being used increasingly as a modality than can provide important information about breast cancer. Diffusion weighted imaging (DWI) is an imaging technique from which ADC values can be calculated in addition to obtaining important structural information which cannot be obtained from other imaging studies. We did not find any significant relationships between ADC values and prognostic factors, but did provide some explanations for conflicting results in the literature...
January 4, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29291189/osseous-outgrowth-on-the-buccal-maxilla-associated-with-piezosurgery-assisted-en-masse-retraction-a-case-series
#12
Nilüfer İrem Tunçer, Ayça Arman-Özçırpıcı, Bahar Füsun Oduncuoğlu, Alpdoğan Kantarcı
Piezoelectric surgery is a novel surgical approach used in orthodontic treatment for rapid tooth movement. This paper presents a case series wherein osseous outgrowths were observed in response to piezosurgery-assisted en-masse retraction. Sixteen patients requiring upper premolar extractions were treated with miniscrew-supported en-masse retraction and received minimally invasive decortication via piezosurgery. Computed tomography (CT) of the maxillary anterior region was performed to investigate the nature of the outgrowths...
January 2018: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/29285481/comparing-the-frequency-of-endometritis-in-unexplained-infertility-and-anovulatory-infertility
#13
Ataollah Ghahiri, Bahare Malekzadeh, Hatav Ghassemi Tehrani
Background: Acute pelvic inflammatory disease (PID) is a common reason for infertility. This study aimed to evaluate the frequency distribution of endometritis in women with unexplained infertility and comparison with frequency distribution of endometritis in anovulatory infertility to identify the importance of endometritis due to subacute PID evaluation in the case of infertility. Materials and Methods: This case-control study was done on 100 women with unexplained infertility and ovulatory infertility who referred to Shahid Beheshti clinic in 2013 in Isfahan, Iran...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29284182/cryptococcosis-and-cryptococcal-meningitis-new-predictors-and-clinical-outcomes-at-a-united-states-academic-medical-center
#14
Bahar H Kashef Hamadani, Carlos Franco-Paredes, Bruce McCollister, Leland Shapiro, David Beckham, Andrés F Henao-Martínez
Since the diagnosis of cryptococcosis is challenging in low prevalence settings, uncovering predictive factors can improve early diagnosis and timely treatment. The aim of the study was to relate clinical outcomes to predictive variables for the presence of cryptococcosis. A retrospective case-control study matching by collection date, age, and gender at a 1:2 ratio (55 cases and 112 controls) was performed in case patients diagnosed with Cryptococcus infection at the University of Colorado Hospital between 2000 and 2017 (n=167)...
December 28, 2017: Mycoses
https://www.readbyqxmd.com/read/29282193/plantar-fibromatosis-in-a-mentally-challenged-man-treated-with-intralesional-corticosteroids
#15
Ayse Serap Karadag, Emin Ozlu, Ayse Bahar Ceyran, Mehmet Simsek, Tugba Kevser Uzuncakmak, Ilkin Zindancı, Necmettin Akdeniz
A 21-year-old mentally challenged man presented with a fixed plaque lesion on the right foot, which had been present for 10 years. Dermatologic examination revealed an erythematous, painful, firm, fixed plaque-nodular lesion on the plantar aspect of the right foot (Figure 1A). Nothing of distinction was noted from his family history or his laboratory tests. An incisional biopsy revealed parallel, regular bundles composed of uniform, plump spindle cells. Thin collagen fibers were seen in contact with and located between the spindle cells...
2017: Skinmed
https://www.readbyqxmd.com/read/29278208/identification-of-the-multifaceted-chemopreventive-activity-of-curcumin-against-the-carcinogenic-potential-of-the-food-additive-kbro3
#16
Ismael Obaidi, Michael Higgins, Bojlul Bahar, Jessica L Davis, Tara McMorrow
BACKGROUND: Potassium bromate (KBrO3), a food additive, has been used in many bakery products as an oxidizing agent. It has been shown to induce renal cancer in many in-vitro and in-vivo experimental models Objectives: This study evaluated the carcinogenic potential of potassium bromate (KBrO3) and the chemopreventive mechanisms of the anti-oxidant and anti-inflammatory phytochemical, curcumin against KBrO3-induced carcinogenicity Method: Lactate dehydrogenase (LDH) cytotoxicity assay and morphological characteristics were used to assess curcumin's cytoprotective potential against KBrO3 toxicity...
December 26, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29277169/evaluating-the-%C3%A2-10-1-wholegrain-criterion-in-identifying-nutrient-quality-and-health-implications-of-uk-breads-and-breakfast-cereals
#17
Bahar Ghodsian, Angela M Madden
OBJECTIVE: To evaluate the nutrient quality of breads and breakfast cereals identified using the wholegrain definition of ≤10:1 carbohydrate:fibre ratio. DESIGN: Following a cross-sectional study design, nutritional information was systematically gathered from food labels of breads and breakfast cereals that met the ≤10:1 carbohydrate:fibre criterion. The median nutrient content was compared with the UK Food Standards Agency's nutrient profiling standards and the associations between carbohydrate:fibre ratio and other nutrients were analysed...
December 26, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29276872/successful-treatment-of-a-childhood-synovitis-acne-pustulosis-hyperostosis-and-osteitis-sapho-syndrome-with-subcutaneous-methotrexate-a-case-report
#18
Meltem Akçaboy, Sevcan Azime Bakkaloğlu-Ezgü, Bahar Büyükkaragöz, Emel Isıyel, Yasar Kandur, Enver Hasanoğlu, Necla Buyan
Akçaboy M, Bakkaloğlu-Ezgü SA, Büyükkaragöz B, Isıyel E, Kandur Y, Hasanoğlu E, Buyan N. Successful treatment of a childhood synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with subcutaneous methotrexate: A case report. Turk J Pediatr 2017; 59: 184-188. SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) is defined as a syndrome that is related to various osteoarticular manifestations and chronic dermatological conditions especially severe acne. SAPHO syndrome is a rare and unusual clinical entity in childhood and treatment choices are variable...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29273220/simulation-of-low-density-lipoprotein-ldl-permeation-into-multilayer-coronary-arterial-wall-interactive-effects-of-wall-shear-stress-and-fluid-structure-interaction-in-hypertension
#19
Mehrdad Roustaei, Mohammad Reza Nikmaneshi, Bahar Firoozabadi
Due to increased atherosclerosis-caused mortality, identification of its genesis and development is of great importance. Although, key factors of the origin of the disease is still unknown, it is widely believed that cholesterol particle penetration and accumulation in arterial wall is mainly responsible for further wall thickening and decreased rate of blood flow during a gradual progression. To date, various effective components are recognized whose simultaneous consideration would lead to a more accurate approximation of Low Density Lipoprotein (LDL) distribution within the wall...
December 7, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29262358/allosteric-modulation-of-intact-%C3%AE-secretase-structural-dynamics
#20
Ji Young Lee, Zhiwei Feng, Xiang-Qun Xie, Ivet Bahar
As a protease complex involved in the cleavage of amyloid precursor proteins that lead to the formation of amyloid β fibrils implicated in Alzheimer's disease, γ-secretase is an important target for developing therapeutics against Alzheimer's disease. γ-secretase is composed of four subunits: nicastrin (NCT) in the extracellular (EC) domain, presenilin-1 (PS1), anterior pharynx defective 1, and presenilin enhancer 2 in the transmembrane (TM) domain. NCT and PS1 play important roles in binding amyloid β precursor proteins and modulating PS1 catalytic activity...
December 19, 2017: Biophysical Journal
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