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https://www.readbyqxmd.com/read/28736150/prenatal-environmental-chemical-exposures-and-longitudinal-patterns-of-child-neurobehavior
#1
Joseph M Braun, Kimberly Yolton, Shaina L Stacy, Bahar Erar, George D Papandonatos, David C Bellinger, Bruce P Lanphear, Aimin Chen
BACKGROUND: Prenatal chemical exposures may adversely affect neurodevelopment, but few studies have examined the persistence of these associations. We examined whether associations between prenatal bisphenol A (BPA) or polybrominated diphenyl ether (PBDE) exposures persist or resolve as children age. METHODS: We followed 346 mother-child pairs (enrolled 2003-2006) from Cincinnati, OH from pregnancy until children were 8 years old. We measured BPA in urine collected at 16 and 26 weeks gestation and PBDE-47 in serum collected at 16 weeks gestation...
July 20, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28726559/supercritical-carbon-dioxide-sc-co2-assisted-decellularization-of-aorta-and-cornea
#2
Selcan Guler, Bahar Aslan, Pezhman Hosseinian, Halil Murat Aydin
Tissue engineering approaches utilize both natural and synthetic materials in the repair and regeneration processes. A naturally-sourced material for this purpose is required to be free from any antigenic matter such as cells or cellular components. Decellularization of tissues may be achieved via chemical or physical removal agents. Supercritical carbon dioxide (sc-CO2) has been used as a means of removing bioburden from tissues and offers an alternative to the traditionally-used treatment methods. In addition to the many advantages it offers with regard to the successful decellularization of tissues, and known to have a sterilization effect...
July 20, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28714753/pediatric-acute-onset-neuropsychiatric-syndrome-response-to-oral-corticosteroid-bursts-an-observational-study-of-patients-in-an-academic-community-based-pans-clinic
#3
Kayla Brown, Cristan Farmer, Bahare Farhadian, Joseph Hernandez, Margo Thienemann, Jennifer Frankovich
BACKGROUND: Sudden-onset severe obsessive-compulsive symptoms and/or severely restrictive food intake with at least two coinciding, similarly debilitating neuropsychiatric symptoms define Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). When associated with Group A Streptococcus, the syndrome is labeled Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS). An abnormal immune response to infection and subsequent neuroinflammation is postulated to play an etiologic role...
July 17, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28710426/targeting-of-dopamine-transporter-to-filopodia-requires-an-outward-facing-conformation-of-the-transporter
#4
Shiqi Ma, Mary H Cheng, Daryl A Guthrie, Amy H Newman, Ivet Bahar, Alexander Sorkin
Dopamine transporter (DAT) has been shown to accumulate in filopodia in neurons and non-neuronal cells. To examine the mechanisms of DAT filopodial targeting, we used quantitative live-cell fluorescence microscopy, and compared the effects of the DAT inhibitor cocaine and its fluorescent analog JHC1-64 on the plasma membrane distribution of wild-type DAT and two non-functional DAT mutants, R60A and W63A, that do not accumulate in filopodia. W63A did not bind JHC1-64, whereas R60A did, although less efficiently compared to the wild-type DAT...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704304/arterial-tree-anomalies-in-patients-with-clubfoot-an-investigation-carried-out-at-soba-university-hospital
#5
Samir Shaheen, Mustafa E H Bahar, Almigdad H A Mohammed, Sara F A Elbadri, Ashok Johari
Vascular deficiencies and reduced perfusion of the anterior tibial artery and the dorsalis pedis artery were suggested as causes of congenital talipes equino varus (CTEV). In this study, we assessed the prevalence of arterial abnormalities in patients with CTEV (50 patients; 74 feet) compared with a normal control group (16 patients; 32 feet) by Doppler ultrasound and Ankle Brachial Index. The flow was normal in the control group and was deficient in 39.19% of clubfoot patients. In severe clubfoot cases, the deficiency was found to an extent of 76...
July 12, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28696786/effect-of-early-and-prophylactic-nonsteroidal-anti-inflammatory-drugs-on-flare-duration-in-pediatric-acute-onset-neuropsychiatric-syndrome-an-observational-study-of-patients-followed-by-an-academic-community-based-pediatric-acute-onset-neuropsychiatric-syndrome
#6
Kayla D Brown, Cristan Farmer, G Mark Freeman, Ellen J Spartz, Bahare Farhadian, Margo Thienemann, Jennifer Frankovich
INTRODUCTION: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by the sudden onset of severe obsessive-compulsive symptoms and/or eating restriction along with at least two coinciding neuropsychiatric symptoms. When associated with group A Streptococcus, the syndrome is labeled Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS). An abnormal immune response to infection and subsequent neuroinflammation is postulated to play an etiologic role...
July 11, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28696783/course-of-neuropsychiatric-symptoms-after-introduction-and-removal-of-nonsteroidal-anti-inflammatory-drugs-a-pediatric-observational-study
#7
Ellen J Spartz, G Mark Freeman, Kayla Brown, Bahare Farhadian, Margo Thienemann, Jennifer Frankovich
OBJECTIVE: Accumulating evidence suggests that anti-inflammatory interventions can modulate neuropsychiatric symptoms. Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by an abrupt and dramatic onset of obsessive-compulsive (OC) symptoms and/or severely restrictive food intake and at least two coinciding, equally debilitating neuropsychiatric symptoms. When associated with group A Streptococcus, the syndrome is labeled Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS)...
July 11, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28694178/medicinal-plants-used-in-the-treatment-of-tuberculosis-ethnobotanical-and-ethnopharmacological-approaches
#8
REVIEW
Javad Sharifi-Rad, Bahare Salehi, Zorica Z Stojanović-Radić, Patrick Valere Tsouh Fokou, Marzieh Sharifi-Rad, Gail B Mahady, Majid Sharifi-Rad, Mohammad-Reza Masjedi, Temitope O Lawal, Seyed Abdulmajid Ayatollahi, Javid Masjedi, Razieh Sharifi-Rad, William N Setzer, Mehdi Sharifi-Rad, Farzad Kobarfard, Atta-Ur Rahman, Muhammad Iqbal Choudhary, Athar Ata, Marcello Iriti
Tuberculosis is a highly infectious disease declared a global health emergency by the World Health Organization, with approximately one third of the world's population being latently infected with Mycobacterium tuberculosis. Tuberculosis treatment consists in an intensive phase and a continuation phase. Unfortunately, the appearance of multi drug-resistant tuberculosis, mainly due to low adherence to prescribed therapies or inefficient healthcare structures, requires at least 20months of treatment with second-line, more toxic and less efficient drugs, i...
July 8, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28692870/air-assisted-liquid-liquid-microextraction-using-floating-organic-droplet-solidification-for-simultaneous-extraction-and-spectrophotometric-determination-of-some-drugs-in-biological-samples-through-chemometrics-methods
#9
Farnaz Farahmand, Bahar Ghasemzadeh, Abdolhossein Naseri
An air assisted liquid-liquid microextraction by applying the solidification of a floating organic droplet method (AALLME-SFOD) coupled with a multivariate calibration method, namely partial least squares (PLS), was introduced for the fast and easy determination of Atenolol (ATE), Propanolol (PRO) and Carvedilol (CAR) in biological samples via a spectrophotometric approach. The analytes would be extracted from neutral aqueous solution into 1-dodecanol as an organic solvent, using AALLME. In this approach a low-density solvent with a melting point close to room temperature was applied as the extraction solvent...
July 3, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28692800/n-6-formyllysine-as-a-biomarker-of-formaldehyde-exposure-formation-and-loss-of-n-6-formyllysine-in-nasal-epithelium-in-long-term-low-dose-inhalation-studies-in-rats
#10
Bahar Edrissi, Koli Taghizadeh, Benjamin C Moeller, Rui Yu, Dean Kracko, Melanie Doyle-Eisele, James A Swenberg, Peter C Dedon
Exposure to both endogenous and exogenous formaldehyde has been established to be carcinogenic, likely by virtue of forming nucleic acid and proteins adducts such as N(6)-formyllysine. To better assess N(6)-formyllysine as a biomarker of formaldehyde exposure, we studied accumulation of N(6)-formyllysine adducts in tissues of rats exposed by inhalation to 2 ppm [(13)C(2)H2]-formaldehyde for 7, 14, 21, and 28 days (6h/day) and investigated adduct loss over a 7-day post-exposure period using liquid chromatography-coupled tandem mass spectrometry...
July 10, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28678078/responsiveness-of-the-electrically-stimulated-cochlear-nerve-in-children-with-cochlear-nerve-deficiency
#11
Shuman He, Bahar S Shahsavarani, Tyler C McFayden, Haibo Wang, Katherine E Gill, Lei Xu, Xiuhua Chao, Jianfen Luo, Ruijie Wang, Nancy He
OBJECTIVES: This study aimed to (1) investigate the responsiveness of the cochlear nerve (CN) to a single biphasic-electrical pulse in implanted children with cochlear nerve deficiency (CND) and (2) compare their results with those measured in implanted children with normal-size CNs. DESIGN: Participants included 23 children with CND (CND1 to CND23) and 18 children with normal-size CNs (S1 to S18). All subjects except for CND1 used Cochlear Nucleus cochlear implants with contour electrode arrays in their test ears...
July 1, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28676990/intra-scleral-fixation-of-the-iris-hooks-for-trans-scleral-capsular-bag-fixation-in-patient-with-zonular-dialysis
#12
Remzi Karadag, Unsal Sari, Bahar Gunes
PURPOSE: To report a technique of intra-scleral fixation of the iris hooks for trans-scleral capsular bag fixation in patient with zonular dialysis. METHODS: Two scleral flaps, two scleral tunnels and two sclerotomies were formed. The anterior capsule was captured and pulled by the iris hooks resulting in the IOL adopting an appropriate position at which point the iris hooks extracted from the sclerotomies. The tips of the iris hooks were implanted into the scleral tunnels...
July 4, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28672072/the-blue-bubble-technique-an-ab-interno-approach-for-descemet-separation-in-deep-anterior-lamellar-keratoplasty-dalk-using-trypan-blue-stained-viscoelastic-device
#13
Eitan Livny, Irit Bahar, Naama Hammel, Yoav Nahum
BACKGROUND: In this study we examined a novel variant of "Big-Bubble" Deep Anterior Lamellar Keratoplasty (DALK) using trypan-blue-stained viscoelastic device for the creation of a pre-Descemetic bubble. METHODS: Ten corneoscleral rims were mounted on an artificial anterior chamber (AC). The anterior chamber was filled with air through a limbal paracentesis. A Melles' triangulated spatula was inserted through the paracentesis, with its tip penetrating the AC, was then slightly retracted and pushed into the deep stroma above the roof of the paracentesis...
July 3, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28664934/cytologic-predictors-of-malignancy-in-bile-duct-brushings-a-multi-reviewer-analysis-of-60-cases
#14
Vaidehi Avadhani, Ezgi Hacihasanoglu, Bahar Memis, Burcin Pehlivanoglu, Krisztina Z Hanley, Uma Krishnamurti, Alyssa M Krasinskas, Adeboye O Osunkoya, Lauren M Daniels, Alexa A Freedman, Michael Goodman, Volkan Adsay, Michelle D Reid
Diagnosing malignancy in bile duct brushings is highly challenging. Seven reviewers of variable backgrounds and levels of participation in bile duct brushing sign out blindly reviewed 60 specimens (30 malignant with histologic confirmation and 30 benign (15 stented) with resection or ≥18 months of uneventful follow-up), testing the utility of 14 malignant characteristics. Eleven characteristics were statistically significantly associated with malignancy including 3-dimensional clusters (63% in malignant vs 3% in benign, odds ratio 50, P=0...
June 30, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28663356/appendiceal-mucinous-neoplasms-diagnosis-and-management
#15
Walid L Shaib, Rita Assi, Ali Shamseddine, Olatunji B Alese, Charles Staley, Bahar Memis, Volkan Adsay, Tonios Bekaii-Saab, Bassel F El-Rayes
OBJECTIVE: Appendiceal mucinous neoplasms (AMNs) are a rare and heterogeneous disease for which clinical management is challenging. We aim to review the literature regarding modalities of treatment to guide the management of AMNs. METHODS AND REVIEW CRITERIA: We conducted a PubMed search in February 2016 for English-language publications, using the terms "appendiceal," "appendix," "carcinoma," "cancer," "mucinous," "treatment," "genes," "target," "genomic," and terms listed in the articles' subheadings...
June 29, 2017: Oncologist
https://www.readbyqxmd.com/read/28662776/an-atypical-presentation-of-paget-s-disease-of-the-breast-without-nipple-involvement-case-report-and-review-of-the-literature
#16
Justine S Broecker, Charles W Sewell, Bahig M Shehata, Bahar Memis, Nazmi V Adsay, Toncred M Styblo
We present a case of a 63 year-old Caucasian female who developed a right breast skin lesion discrete from the nipple that was subsequently diagnosed as Paget's Disease of the breast (PDB). Imaging did not reveal an underlying breast cancer or involvement of the nipple. The patient underwent a segmental mastectomy preserving the nipple and final pathology demonstrated residual Paget's disease of the skin and did not reveal any additional underlying breast carcinoma. To our knowledge, this case represents the first reported diagnosed case of isolated PDB without nipple involvement...
June 10, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28648840/reducing-fluid-related-complications-during-operative-hysteroscopy-the-use-of-a-new-mandatory-fluid-balance-form
#17
Heli Alkaslassy, Raz Bahar, Hillel Henry Chill, Gilad Karavani, Orna Ben-Yosseff, Asher Shushan
STUDY OBJECTIVE: To examine whether our new reporting system and mandatory fluid-balance form could improve the communication and awareness within the surgical team and therefore the safety of hysteroscopic operations. DESIGN: A case-control study DESIGN: classification: II-2 SETTING: An endoscopic gynecology unit at a tertiary-care university hospital. PATIENTS: Women aged 17-88 (median 43.9) years, who underwent operative hysteroscopy to treat uterine pathology...
June 22, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28648616/dynamic-modulation-of-binding-affinity-as-a-mechanism-for-regulating-interferon-signaling
#18
Hongchun Li, Nanaocha Sharma, Ignacio J General, Gideon Schreiber, Ivet Bahar
How structural dynamics affects cytokine signaling is under debate. Here, we investigated the dynamics of the type I interferon (IFN) receptor, IFNAR1, and its effect on signaling upon binding IFN and IFNAR2 using a combination of structure-based mechanistic studies, in situ binding and gene induction assays. Our study reveals that IFNAR1 flexibility modulates ligand-binding affinity, which, in turn, regulates biological signaling. We identified the hinge sites and key interactions implicated in IFNAR1 inter-subdomain (SD1-SD4) movements...
June 22, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28648433/the-importance-of-recognizing-the-prominent-eustachian-valve-in-the-evaluation-of-atrial-septal-defects-before-percutaneous-or-surgical-closure
#19
Burak Acar, Ozcan Ozeke, Bahar Tekin Tak, Ahmet Akdi, Firdevs Aysenur Ekizler, Habibe Kafes, Kadir Ocak, Zehra Golbasi, Omac Tufekcioglu, Erdogan Ilkay
Atrial septal defect closure is now routinely performed using a percutaneous approach under echocardiographic guidance. Since some echocardiographic features play an important role in the assessment of the defect and safety of the procedure, the salient features of the anatomical variations seen in adults undergoing transcatheter device closure should be well known to prevent inadvertent adverse effect or complications. It has been reported that the valve of the inferior vena cava, Eustachian valve, could be mistaken as the atrial septum thus ending in a wrong diagnosis and causing inadvertent surgical or percutaneous closure of an Eustachian valve to interatrial septum...
May 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28647905/time-dependent-leaf-proteome-alterations-of-brachypodium-distachyon-in-response-to-drought-stress
#20
Ozge Tatli, Bahar Sogutmaz Ozdemir, Gizem Dinler Doganay
For the first time, a comprehensive proteome analysis was conducted on Brachypodium leaves under drought stress. Gradual changes in response to drought stress were monitored. Drought is one of the major stress factors that dramatically affect the agricultural productivity worldwide. Improving the yield under drought is an urgent challenge in agriculture. Brachypodium distachyon is a model species for monocot plants such as wheat, barley and several potential biofuel grasses. In the current study, a comprehensive proteome analysis was conducted on Brachypodium leaves under different levels of drought application...
June 24, 2017: Plant Molecular Biology
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