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https://www.readbyqxmd.com/read/27684082/intraobserver-reliability-and-interobserver-agreement-in-radiographic-classification-of-heterotopic-ossification
#1
Georgios I Vasileiadis, Yodhiaki Itoigawa, Derek F Amanatullah, Luis Pulido-Sierra, Jeremy R Crenshaw, Christine Huyber, Michael J Taunton, Kenton R Kaufman
The most widely used radiologic classification system for heterotopic ossification after total hip arthroplasty (THA) is the Brooker scale. In 2002, Della Valle et al proposed a modified rating system for heterotopic ossification to increase intraobserver reliability and interobserver agreement. To date, no study comparing these 2 classification systems has been conducted. Moreover, these studies were grossly underpowered. In the current study, 3 clinicians reviewed the charts of 236 patients with documented radiographic heterotopic ossification at least 2 months after THA and independently graded the amount of heterotopic ossification according to the Brooker and Della Valle classification systems...
September 29, 2016: Orthopedics
https://www.readbyqxmd.com/read/27680702/xpo1-dependent-nuclear-export-is-a-druggable-vulnerability-in-kras-mutant-lung-cancer
#2
Jimi Kim, Elizabeth McMillan, Hyun Seok Kim, Niranjan Venkateswaran, Gurbani Makkar, Jaime Rodriguez-Canales, Pamela Villalobos, Jasper Edgar Neggers, Saurabh Mendiratta, Shuguang Wei, Yosef Landesman, William Senapedis, Erkan Baloglu, Chi-Wan B Chow, Robin E Frink, Boning Gao, Michael Roth, John D Minna, Dirk Daelemans, Ignacio I Wistuba, Bruce A Posner, Pier Paolo Scaglioni, Michael A White
The common participation of oncogenic KRAS proteins in many of the most lethal human cancers, together with the ease of detecting somatic KRAS mutant alleles in patient samples, has spurred persistent and intensive efforts to develop drugs that inhibit KRAS activity. However, advances have been hindered by the pervasive inter- and intra-lineage diversity in the targetable mechanisms that underlie KRAS-driven cancers, limited pharmacological accessibility of many candidate synthetic-lethal interactions and the swift emergence of unanticipated resistance mechanisms to otherwise effective targeted therapies...
September 28, 2016: Nature
https://www.readbyqxmd.com/read/27648196/insight-on-bone-morphogenetic-protein-7-in-ankylosing-spondylitis-and-its-association-with-disease-activity-and-radiographic-damage
#3
Adel Mahmoud, Dalia Fayez, Mervat Mammdouh Abou Gabal, Sherin Mohamed Hosny Hamza, Takwa Badr
INTRODUCTION: Fusion of joints as well as intervertebral spaces by the formation of bony spurs appearing as syndesmophytes and osteophytes are the hallmark of spondyloarthropathies which accounts for disability. The aim of this study was to assess the serum level of bone morphogenetic protein (BMP)-7 in ankylosing spondylitis and its relationship with disease activity and the radiographic damage. METHODS: This longitudinal case control study was conducted in Ain Shams University Hospitals (Egypt)...
July 2016: Electronic Physician
https://www.readbyqxmd.com/read/27617828/heel-spur-and-acupuncture-does-it-work
#4
A E Sahin, Y Cayir, A Imerci, H Uzkeser, F Akcay
Heel spur is also known as a result of plantar calcaneal bone spur which is a common complaint associated with pain at heel. Heel spur is more common in females. Anti-inflammatory drugs, local steroid injections, physical therapy, low-dose radiotherapy and shock wave therapy are the commonly used treatment choices. There is no evidence that acupuncture is an effective method for heel spur in the literature. However, we know that acupuncture can be used for many orthopaedic diseases like frozen shoulder, tennis elbow, sciatic pain, joint sprains, several forms of bursitis and arthritis...
November 11, 2015: West Indian Medical Journal
https://www.readbyqxmd.com/read/27600060/in-silico-bone-mechanobiology-modeling-a-multifaceted-biological-system
#5
Mario Giorgi, Stefaan W Verbruggen, Damien Lacroix
Mechanobiology, the study of the influence of mechanical loads on biological processes through signaling to cells, is fundamental to the inherent ability of bone tissue to adapt its structure in response to mechanical stimulation. The immense contribution of computational modeling to the nascent field of bone mechanobiology is indisputable, having aided in the interpretation of experimental findings and identified new avenues of inquiry. Indeed, advances in computational modeling have spurred the development of this field, shedding new light on problems ranging from the mechanical response to loading by individual cells to tissue differentiation during events such as fracture healing...
November 2016: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/27579849/multimodality-imaging-review-of-the-post-amputation-stump-pain
#6
Nawaraj Subedi, Priam Heire, Vinay Parmer, Simon Beardmore, Chooi Oh, Fergus Jepson, Syed I Ali
Limb amputation is one of the oldest known surgical procedures performed for a variety of indications. Little surgical technical improvements have been made since the first procedure, but perioperative and post-operative refinements have occurred over time. Post-amputation pain (PAP) of the stump is a common complication but is an extremely challenging condition to treat. Imaging allows early diagnosis of the underlying cause so that timely intervention is possible to minimize physical disability with its possible psychological and socioeconomic implications...
December 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27423433/the-simultaneous-occurrence-of-histoplasmosis-and-cryptococcal-fungemia-a-case-report-and-review-of-the-literature
#7
Joslaine de Oliveira Nunes, Kelly Regina Alves Pereira Pillon, Patrícia Lira Bizerra, Anamaria Mello Miranda Paniago, Rinaldo Poncio Mendes, Marilene Rodrigues Chang
Simultaneous infections with Cryptococcus neoformans and Histoplasma capsulatum are rare and typically occur in immunocompromised individuals, particularly AIDS patients. Because both of those fungi can spur the development of latent infections, it is generally unknown which organism was first present. The diagnosis of one fungus can hide the diagnosis of the other, leading to underdiagnoses and poor prognosis. We report a case of C. neoformans and H. capsulatum co-infection. We also performed a systematic review of the literature...
July 16, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27236673/isolation-of-mouse-bone-marrow-mesenchymal-stem-cells
#8
Siddaraju V Boregowda, Veena Krishnappa, Donald G Phinney
Mesenchymal stem cells (MSCs) were initially characterized as connective tissue progenitors resident in bone marrow, but have now been isolated from a variety of tissues and organs and shown to also exhibit potent tissue regenerative properties mediated largely via paracrine actions. These findings have spurred the development of MSC-based therapies for treating a diverse array of nonskeletal diseases. Although genetic and experimental rodent models of disease represent important tools for developing efficacious MSC-based therapies, development of reliable methods to isolate MSCs from mouse bone marrow has been hampered by the unique biological properties of these cells...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27089203/sclerostin-more-than-a-bone-formation-brake
#9
REVIEW
Frank Rauch, Rick Adachi
Anti-sclerostin treatment spurs an unexpected acceleration of bone erosion in a mouse model of rheumatoid arthritis (Wehmeyeret al, this issue).
March 16, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27035682/gene-delivery-nanocarriers-of-bioactive-glass-with-unique-potential-to-load-bmp2-plasmid-dna-and-to-internalize-into-mesenchymal-stem-cells-for-osteogenesis-and-bone-regeneration
#10
Tae-Hyun Kim, Rajendra K Singh, Min Sil Kang, Joong-Hyun Kim, Hae-Won Kim
The recent development of bioactive glasses with nanoscale morphologies has spurred their specific applications in bone regeneration, for example as drug and gene delivery carriers. Bone engineering with stem cells genetically modified with this unique class of nanocarriers thus holds great promise in this avenue. Here we report the potential of the bioactive glass nanoparticle (BGN) system for the gene delivery of mesenchymal stem cells (MSCs) targeting bone. The composition of 15% Ca-added silica, proven to be bone-bioactive, was formulated into surface aminated mesoporous nanospheres with enlarged pore sizes, to effectively load and deliver bone morphogenetic protein-2 (BMP2) plasmid DNA...
April 21, 2016: Nanoscale
https://www.readbyqxmd.com/read/26999695/intranasal-extramucosal-access-a-new-access-for-lateral-osteotomy-in-open-rhinoplasty
#11
Ali Teoman Tellioglu, Elif Sari, Hulda Rifat Ozakpinar, Tolga Eryilmaz, Emre Inozu, Tulin Sen, Ibrahim Tekdemir
BACKGROUND AND OBJECTIVE: Different accesses have been used to perform lateral osteotomies in rhinoplasty. All of them have some disadvantages. The aim of this paper was to report a new access to overcome drawbacks of the other techniques in lateral osteotomy during open rhinoplasty. METHODS: An anatomical study was designed to search possibility of intranasal extramucosal access (open sky access) for the lateral osteotomy in open rhinoplasty. It was performed directly on the lateral wall of piriform aperture, and then possible advantages of this technique were investigated...
May 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/26859203/klippel-feil-syndrome-with-spinal-dysraphism-diastematomyelia-on-18f-naf-bone-pet-ct-and-mri-imaging
#12
Emmanuel W Hudson, William Makis
A 49-year-old woman with known Klippel-Feil syndrome had a CT scan for staging of stage IIIA invasive carcinoma of the left breast. She was found to have cervicothoracic spinal dysraphism with diastematomyelia. An F-NaF bone PET done as part of the metastatic workup showed the characteristic sagittal bone spur, and MRI demonstrated a complete split of the cervical and upper thoracic spinal cord, previously unknown to the patient.
May 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/26776224/the-mechanistic-targets-of-antifungal-agents-an-overview
#13
REVIEW
Tryphon K Mazu, Barbara A Bricker, Hernan Flores-Rozas, Seth Y Ablordeppey
Pathogenic fungi are a major causative group for opportunistic infections (OIs). AIDS patients and other immunocompromised individuals are at risk for OIs, which if not treated appropriately, contribute to the mortality associated with their conditions. Several studies have indicated that the majority of HIV-positive patients contract fungal infections throughout the course of their disease. Similar observations have been made regarding the increased frequency of bone marrow and organ transplants, the use of antineoplastic agents, the excessive use of antibiotics, and the prolonged use of corticosteroids among others...
2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/26697312/use-of-a-bone-graft-drill-harvester-to-create-the-fenestration-during-arthroscopic-ulnohumeral-arthroplasty
#14
Malin D Wijeratna, Eugene T Ek, Gregory A Hoy, Ash Chehata
The Outerbridge-Kashiwagi procedure, or ulnohumeral arthroplasty, was described in 1978 as a method of treating elbow arthritis by creating a fenestration in the olecranon fossa. This fenestration diminishes the likelihood of recurrent spurs in the olecranon fossa and coronoid fossa, without loss of structural bony strength. Arthroscopic techniques have now been developed to perform this procedure. We describe an efficient method of creating the fenestration between the olecranon fossa and coronoid fossa during an arthroscopic ulnohumeral arthroplasty, or Outerbridge-Kashiwagi procedure, that also reduces the amount of residual bone debris produced during the resection...
October 2015: Arthroscopy Techniques
https://www.readbyqxmd.com/read/26644427/higher-body-mass-index-is-associated-with-plantar-fasciopathy-plantar-fasciitis-systematic-review-and-meta-analysis-of-various-clinical-and-imaging-risk-factors
#15
K D B van Leeuwen, J Rogers, T Winzenberg, M van Middelkoop
QUESTION: What (risk) factors are associated with plantar fasciopathy (PF)? DESIGN: Systematic review with meta-analyses. PARTICIPANTS: Patients with PF. FACTORS: All factors described in prospective, case-control or cross-sectional observational studies. RESULTS: 51 included studies (1 prospective, 46 case-control and 4 cross-sectional studies) evaluated a total of 104 variables. Pooling was possible for 12 variables...
August 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/26634249/high-level-of-interleukin-32-gamma-in-the-joint-of-ankylosing-spondylitis-is-associated-with-osteoblast-differentiation
#16
Eun-Ju Lee, Eun-Jin Lee, Yeon-Ho Chung, Da-Hyun Song, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Tae-Hwan Kim, Ye-Soo Park, Soo-Hyun Kim, Eun-Ju Chang, Yong-Gil Kim
BACKGOUND: The formation of bony spurs and ankylosis is a key pathognomic feature in ankylosing spondylitis (AS) and results in functional impairment. The aim of this study was to investigate the role of IL-32γ in osteoblast (OB) differentiation and its association with the pathogenesis of AS. METHODS: The concentration and expression of IL-32γ were evaluated in synovial fluid and tissue from patients with AS, rheumatoid arthritis (RA) and osteoarthritis (OA), using enzyme-linked immunosorbent assay and immunohistochemistry...
2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26633091/heterotopic-ossification-associated-with-myelopathy-following-cervical-disc-prosthesis-implantation
#17
Markus Wenger, Thomas-Marc Markwalder
This case report presents a 37-year-old man with clinical signs of myelopathy almost 9 years after implantation of a Bryan disc prosthesis (Medtronic Sofamor Danek, Memphis, TN, USA) for C5/C6 soft disc herniation. As demonstrated on MRI and CT scan, spinal cord compression was caused by bony spurs due to heterotopic ossification posterior to the still moving prosthesis. The device, as well as the ectopic bone deposits, had to be removed because of myelopathy and its imminent aggravation. Conversion to anterior spondylodesis was performed...
April 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/26606399/the-phylogenetic-distribution-anatomy-and-histology-of-the-post-cloacal-bones-and-adnexa-of-geckos
#18
Anthony P Russell, Matthew K Vickaryous, Aaron M Bauer
Post-cloacal bones of gekkotans may be present as a single (medial) pair, two pairs (medial and lateral), or may be lacking. We, herein, demonstrate that the presence of a single medial pair is the ancestral condition for the Gekkota, that the lateral pair is of sporadic occurrence within and between families, except for the Eublepharidae where it is universal, and that absence is also of sporadic occurrence except for the Sphaerodactylidae where it is the ancestral condition. Adult male Tokay geckos (Gekko gecko) possess only the medial pair of bones, and these exhibit a regionally-specific expression of woven, fibrolamellar, and lamellar bone, and an enclosed medullary cavity...
February 2016: Journal of Morphology
https://www.readbyqxmd.com/read/26430601/sacroiliac-coalition-first-description-and-report-of-a-successful-resection
#19
Axel Greiner, Andrea Baur-Melnyk, Sabina Berezowska, Melvin D'Anastasi, Christof Birkenmaier
Study Design Case report. Objective This report describes the first case of a sacroiliac coalition, its clinical features, the diagnostic difficulties, and the surgical treatment chosen in this case. Methods A 33-year-old man presented to our outpatient clinics complaining of severe left-sided low back pain with an intermitted nondermatomal radiation into the left thigh. The only abnormality on a pelvic radiograph was a coin-size, faint hyperdensity, which was almost overlooked. Subsequent computed tomography (CT) and magnetic resonance imaging (MRI) confirmed two bridging bone spurs on the anterior surface of the left joint with a fibrous interruption at the apex...
October 2015: Global Spine Journal
https://www.readbyqxmd.com/read/26352588/single-cell-rna-seq-of-bone-marrow-derived-mesenchymal-stem-cells-reveals-unique-profiles-of-lineage-priming
#20
COMPARATIVE STUDY
Brian T Freeman, Jangwook P Jung, Brenda M Ogle
The plasticity and immunomodulatory capacity of mesenchymal stem cells (MSCs) have spurred clinical use in recent years. However, clinical outcomes vary and many ascribe inconsistency to the tissue source of MSCs. Yet unconsidered is the extent of heterogeneity of individual MSCs from a given tissue source with respect to differentiation potential and immune regulatory function. Here we use single-cell RNA-seq to assess the transcriptional diversity of murine mesenchymal stem cells derived from bone marrow...
2015: PloS One
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