Cecile Riviere-Cazaux, Lucas P Carlstrom, Bryan J Neth, Ian E Olson, Karishma Rajani, Masum Rahman, Samar Ikram, Moustafa A Mansour, Bipasha Mukherjee, Arthur E Warrington, Susan C Short, Thomas von Zglinicki, Desmond A Brown, Sandeep Burma, Tamar Tchkonia, Marissa J Schafer, Darren J Baker, Sani H Kizilbash, James L Kirkland, Terry C Burns
High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven durable salvage therapies for patients that have failed conventional treatments. Post-treatment, the latent glioma and its microenvironment are characterized by a senescent-like state of mitotic arrest and a senescence-associated secretory phenotype (SASP) induced by prior chemoradiation. Although senescence was once thought to be irreversible, recent evidence has demonstrated that cells may escape this state and re-enter the cell cycle, contributing to tumor recurrence...
November 29, 2023: NPJ Precision Oncology