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https://www.readbyqxmd.com/read/29682379/extensor-tendons-rupture-after-volar-plating-of-distal-radius-fracture-related-to-a-dorsal-radial-metaphyseal-bone-spur
#1
M O Abrego, F L De Cicco, J G Boretto, G L Gallucci, P De Carli
Extensor tendon ruptures due to volar plating in distal radius fractures have mostly been described in relation with technique failures such as screw prominence and drill penetration. We report the case of a 71-year-old female with a C2 distal radius fracture with severe dorsal metaphyseal comminution. The patient underwent surgical treatment with reduction of the large fragments and fixation with a volar locking plate; the small dorsal metaphyseal nonarticular fragments were not reduced. Six months later, the patient developed extensor digitorum communis (EDC) rupture and extensor indicis proprius (EIP) laceration in coincidence with the dorsal comminution turned into a bony spur...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29659379/bony-reconstruction-of-the-anterior-glenoid-rim
#2
Laurent B Willemot, Bassem T Elhassan, Olivier Verborgt
Recurrent anterior shoulder instability is associated with glenohumeral bone loss. Glenoid deficiency compromises the concavity-compression mechanism. Medial Hill-Sachs lesions can result in an off-track humeral position. Anterior glenoid reconstruction or augmentation prevents recurrence by addressing the pathomechanics. In Bristow and Latarjet procedures, the coracoid process is harvested for conjoint tendon transfer, capsular reinforcement, and glenoid rim restoration. Complications and the nonanatomic nature of the procedure have spurred research on graft sources...
May 15, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29629144/label-free-raman-spectroscopy-provides-early-determination-and-precise-localization-of-breast-cancer-colonized-bone-alterations
#3
Chi Zhang, Paul T Winnard, Sidarth Dasari, Scott L Kominsky, Michele Doucet, Swaathi Jayaraman, Venu Raman, Ishan Barman
Breast neoplasms frequently colonize bone and induce development of osteolytic bone lesions by disrupting the homeostasis of the bone microenvironment. This degenerative process can lead to bone pain and pathological bone fracture, a major cause of cancer morbidity and diminished quality of life, which is exacerbated by our limited ability to monitor early metastatic disease in bone and assess fracture risk. Spurred by its label-free, real-time nature and its exquisite molecular specificity, we employed spontaneous Raman spectroscopy to assess and quantify early metastasis driven biochemical alterations to bone composition...
January 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29571326/identification-and-complete-stereochemical-assignments-of-the-new-resolvin-conjugates-in-tissue-regeneration-in-human-tissues-that-stimulate-proresolving-phagocyte-functions-and-tissue-regeneration
#4
Xavier de la Rosa, Paul C Norris, Nan Chiang, Ana R Rodriguez, Bernd W Spur, Charles N Serhan
Resolvin conjugates in tissue regeneration (RCTRs) are new chemical signals that accelerate resolution of inflammation, infection, and tissue regeneration. Herein, using liquid chromatography-tandem mass spectrometry-based metabololipidomics, we identified RCTRs in human spleen, lymph node, bone marrow, and brain. In human spleen incubated with Staphylococcus aureus, endogenous RCTRs were increased along with conversion of deuterium-labeled docosahexaenoic acid, conferring pathway activation. Physical and biological properties of endogenous RCTRs were matched with those prepared by total organic synthesis...
April 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29534911/incidence-and-morphometry-of-sellar-bridges-and-related-foramina-in-dry-skulls-their-significance-in-middle-cranial-fossa-surgery
#5
Konstantinos Natsis, Maria Piagkou, Nikolaos Lazaridis, Trifon Totlis, Nikolaos Anastasopoulos, Jannis Constantinidis
PURPOSE: The current study investigated the incidence, morphology and morphometry of the ossified ligaments expanding between petrous bone and posterior clinoid processes and in between the anterior, middle and posterior clinoid processes. Side symmetry, gender dimorphism and age influence were also studied. MATERIALS AND METHODS: A total of 123 adult Greek dry skulls were observed. RESULTS: A caroticoclinoid bar (CCB) was found in 60.2%. Partial CCBs appeared more commonly (36...
April 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29531796/two-stage-corrective-surgery-for-severe-rigid-cervical-kyphotic-deformity-with-unilateral-vertebral-artery-occlusion-after-old-blunt-trauma-a-case-report
#6
Tsunehiko Konomi, Kota Suda, Satoko Matsumoto, Miki Komatsu, Masahiko Takahata, Norimasa Iwasaki, Akio Minami
Introduction: There are considerable risks for vertebral artery (VA) injury in case of corrective surgery for a severe and rigid cervical kyphotic deformity. This case report describes a rare case of surgical management for pre-existing traumatic rigid cervical kyphosis associated with unilateral VA occlusion. Case presentation: A 73-year-old male fell down and injured his neck. He was referred to our hospital 10 months after injury because his degree of head drop progressed gradually to a chin-on-chest position such that he could not look straight forward...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29527319/inferior-heel-pain-in-soccer-players-a-retrospective-study-with-a-proposal-for-guidelines-of-treatment
#7
Raoul Saggini, Maurizio Migliorini, Simona Maria Carmignano, Emilio Ancona, Chiara Russo, Rosa Grazia Bellomo
Background: The cause of heel pain among soccer players is multifactorial and is related to repetitive microtrauma due to impact forces involving technical moves, but also the playground, the exercise mode, the recovery time, the climatic conditions and the footwear used. Aim: To investigate the aetiology of plantar heel pain of soccer players with the objective of proposing an example of guidelines for treatment. Methods: We investigated the prevalence and characteristics of inferior heel pain of 1473 professional, semiprofessional and amateur players...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29487753/acquired-elliptocytosis-as-a-manifestation-of-myelodysplastic-syndrome-associated-with-deletion-of-chromosome-20q
#8
Sukesh Manthri, Naresh K Vasireddy, Sindhura Bandaru, Swati Pathak
Elliptocytosis is commonly seen as a hereditary condition. We present a case of myelodysplastic syndrome (MDS) del(q20) variant with concomitant acquired elliptocytosis. A 73-year-old male with a history of prostate cancer presented to the hospital for evaluation of bleeding gums. Initial evaluation showed Hgb of 9.3 gm/dl, hematocrit of 28%, platelet count of 36,000 K/cmm, and WBC of 1.8 K/cmm with an ANC of 0.8 K/cmm. A slightly elevated bilirubin of 1.2 mg/dl spurred a hemolytic workup. Peripheral smear showed frequent elliptocytes, teardrop cells, schistocytes, and occasional spherocytes...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29446010/phosphaturic-mesenchymal-tumors-what-an-endocrinologist-should-know
#9
REVIEW
J M Boland, P J Tebben, A L Folpe
Tumor-induced osteomalacia (TIO), also known as "oncogenic osteomalacia", is a rare cause of osteomalacia. TIO often has an insidious onset characterized clinically by progressive muscle weakness and bone pain with fractures. The hallmark biochemical finding is a persistent low serum phosphorus concentration due to renal phosphate wasting. The vast majority of cases of TIO result from production of the phosphaturic hormone fibroblast growth factor 23 (FGF23) by a histologically distinctive mesenchymal tumor, termed "phosphaturic mesenchymal tumor" (PMT)...
February 14, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29409190/clinical-presentation-and-surgical-management-of-chronic-achilles-tendon-disorders-a-retrospective-observation-on-a-set-of-consecutive-patients-being-operated-by-the-same-orthopedic-surgeon
#10
Håkan Alfredson, Christoph Spang
BACKGROUND: Non-invasive treatment is not always successful in patients with Achilles tendon disorders, and surgical treatment is instituted as the next step. There is sparse knowledge about the diagnoses, pain levels before surgery, surgically confirmed pathologies and postoperative complications in large patient groups. AIMS: To study the diagnoses, pain scores before surgery, macroscopic surgical findings and postoperative complications in a series of patients treated for Achilles disorders...
June 12, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29405773/brain-infarction-due-to-vertebral-artery-dissection-caused-by-a-bone-protrusion-from-the-condylar-fossa-in-a-juvenile-case
#11
Mutsumi Fujii, Miki Ohgushi, Takaaki Chin
A 16-year-old boy presented with multiple posterior circulation ischemic strokes resulting from vertebral artery (VA) dissection. Three-dimensional computed tomography showed aberrant sub-occipital bone protuberance, proximal to the VA dissection. Since the patient was a habitual neck cracker, VA dissection was thought to result from the impact shock of the rotational head movement. This could be due to either the osseous prominence or the compression between the prominence and the C1. Although it is a rare etiology of Bow Hunter's syndrome, VA dissection due to sub-occipital bone spur because of neck cracking should be considered in the diagnosis of Bow Hunter's syndrome in juvenile patients...
February 6, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29380255/the-teramoto-distal-tibial-oblique-osteotomy-dtoo-surgical-technique-and-applicability-for-ankle-osteoarthritis-with-varus-deformity
#12
Tsukasa Teramoto, Shota Harada, Motoyuki Takaki, Tomohiko Asahara, Narutaka Kato, Nobuyuki Takenaka, Takasi Matsushita, Yosiaki Makino, Kouitiro Tasiro, Ootuka Kazutaka, Yukinobu Nishi, Kiyoto Kinugsa
We have devised a medial peri-articular osteotomy, the distal tibial oblique osteotomy (DTOO), and have used this technique since 1994 for ankle osteoarthritis of advanced and late stages associated with varus inclination. This report describes the surgical technique and its applicability. DTOO can be used for cases of varus ankle osteoarthritis with a range of the ankle joint movement of at least 10° or more. The osteotomy is obliquely directed cut across the distal tibia from proximal-medial to distal lateral and is of an opening-wedge type with the centre of rotation coincident with the centre of the tibiofibular joint...
April 2018: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/29355746/bone-remodelling-in-vitro-where-are-we-headed-a-review-on-the-current-understanding-of-physiological-bone-remodelling-and-inflammation-and-the-strategies-for-testing-biomaterials-in-vitro
#13
REVIEW
Nupur Kohli, Sonia Ho, Stuart J Brown, Prasad Sawadkar, Vaibhav Sharma, Martyn Snow, Elena García-Gareta
Bone remodelling is a dynamic process required for the maintenance of bone architecture in response to the changing mechanical needs. It is also a vital process during the repair of bone tissue following injury. Clinical intervention in terms of autografting or allografting is often required to heal bone injuries where physiological healing fails. The use of biomaterials as alternatives to autografts and allografts has spurred a significant research interest into further development of biomaterials for better clinical outcomes...
May 2018: Bone
https://www.readbyqxmd.com/read/29327557/-surgical-treatment-for-14-patients-with-old-fractures-of-humeral-lateral-condyle-in-children
#14
Kai Liu, Ru-Guo Shang, Yan Xiao, Jan-Wei Hu, Yong-Xin Yu
OBJECTIVE: To study clinical effects of operation for the treatment of old fractures of the humerus lateral condyle in children. METHODS: From January 2012 to January 2014 in our department, 14 children of old humeral lateral condyle fractures were treated with operation. Ten cases were male, 4 cases were female; age from 2 to 12 years old, average 5.8 years old. The initial diagnosis was type IIfracture according to the Milch ciassification, the loss of treatment in 11 cases, conservative treatment in 3 cases of nonunion after fracture displacement...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29320322/multidetector-ct-of-midfacial-fractures-classification-systems-principles-of-reduction-and-common-complications
#15
David Dreizin, Arthur J Nam, Silviu C Diaconu, Mark P Bernstein, Uttam K Bodanapally, Felipe Munera
The advent of titanium hardware, which provides firm three-dimensional positional control, and the exquisite bone detail afforded by multidetector computed tomography (CT) have spurred the evolution of subunit-specific midfacial fracture management principles. The structural, diagnostic, and therapeutic complexity of the individual midfacial subunits, including the nose, the naso-orbito-ethmoidal region, the internal orbits, the zygomaticomaxillary complex, and the maxillary occlusion-bearing segment, are not adequately reflected in the Le Fort classification system, which provides only a general framework and has become less relevant in contemporary practice...
January 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29290604/grammont-humeral-design-versus-onlay-curved-stem-reverse-shoulder-arthroplasty-comparison-of-clinical-and-radiographic-outcomes-with-minimum-2-year-follow-up
#16
Giovanni Merolla, Gilles Walch, Francesco Ascione, Paolo Paladini, Elisabetta Fabbri, Antonio Padolino, Giuseppe Porcellini
BACKGROUND: There are few investigations comparing lateralized and medialized reverse total shoulder arthroplasty (RTSA) in patients with cuff tear arthropathy. This study assessed the outcomes of 2 RTSA designs. METHODS: Sixty-eight consecutive cuff tear arthropathy patients (74 shoulders) with a follow-up of at least 24 months received a Grammont or an onlay curved short-stem humeral component, with or without glenoid lateralization; a cementless humeral stem was implanted in >90%...
April 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29288124/adult-hepatocytes-direct-liver-organogenesis-through-non-parenchymal-cell-recruitment-in-the-kidney
#17
Rie Utoh, Junji Komori, Hiroyuki Kuge, Kohei Tatsumi, Masumi Yamada, Shinji Hirohashi, Masahiro Tsutsumi, Toshihiro Amanuma, Akira Yoshioka, Yoshiyuki Nakajima, Kenjiro Wake, Teruo Okano, Eric Lagasse, Kazuo Ohashi
BACKGROUND & AIMS: Since the first account of the myth of Prometheus, the amazing regenerative capacity of the liver has fascinated researchers because of its enormous medical potential. Liver regeneration is promoted by multiple types of liver cells, including hepatocytes and liver non-parenchymal cells (NPCs), through complex intercellular signaling. However, the mechanism of liver organogenesis, especially the role of adult hepatocytes at ectopic sites, remains unknown. In this study, we demonstrate that hepatocytes alone spurred liver organogenesis to form an organ-sized complex 3D liver that exhibited native liver architecture and functions in the kidneys of mice...
December 26, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29277359/soho-state-of-the-art-update-and-next-questions-mpn
#18
REVIEW
Prithviraj Bose, Jason Gotlib, Claire N Harrison, Srdan Verstovsek
The discovery of the activating Janus kinase (JAK)2V617F mutation in 2005 in most patients with the classic Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) spurred intense interest in research into these disorders, culminating in the identification of activating mutations in MPL in 2006 and indels in the gene encoding calreticulin (CALR) in 2013, thus providing additional mechanistic explanations for the universal activation of JAK-signal transducer and activator of transcription (JAK-STAT) observed in these conditions, and the success of the JAK1/2 inhibitor ruxolitinib, which first received regulatory approval in 2011...
January 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29244691/delayed-onset-sciatic-nerve-palsy-after-periacetabular-osteotomy-a-case-report
#19
Michael Leunig, Jonathan M Vigdorchik, Aidin Eslam Pour, Silvia Willi-Dähn, Reinhold Ganz
CASE: A large surgical correction was required for severe hip dysplasia, which was associated with a delayed-onset sciatic nerve injury in an adolescent patient. A cortical bone spur on the outside of the acetabular fragment produced an indirect injury that became symptomatic during mobilization of the patient. CONCLUSION: The risk of direct injury to the sciatic nerve during a periacetabular osteotomy is quite low when the osteotomy is executed in extension with abduction of the hip and flexion of the knee to reduce tension on the sciatic nerve...
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29169668/arthroscopic-subacromial-decompression-for-subacromial-shoulder-pain-csaw-a-multicentre-pragmatic-parallel-group-placebo-controlled-three-group-randomised-surgical-trial
#20
RANDOMIZED CONTROLLED TRIAL
David J Beard, Jonathan L Rees, Jonathan A Cook, Ines Rombach, Cushla Cooper, Naomi Merritt, Beverly A Shirkey, Jenny L Donovan, Stephen Gwilym, Julian Savulescu, Jane Moser, Alastair Gray, Marcus Jepson, Irene Tracey, Andrew Judge, Karolina Wartolowska, Andrew J Carr
BACKGROUND: Arthroscopic sub-acromial decompression (decompressing the sub-acromial space by removing bone spurs and soft tissue arthroscopically) is a common surgery for subacromial shoulder pain, but its effectiveness is uncertain. We did a study to assess its effectiveness and to investigate the mechanism for surgical decompression. METHODS: We did a multicentre, randomised, pragmatic, parallel group, placebo-controlled, three-group trial at 32 hospitals in the UK with 51 surgeons...
January 27, 2018: Lancet
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