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https://www.readbyqxmd.com/read/29016437/a-mouse-intervertebral-disc-degeneration-model-by-surgically-induced-instability
#1
Takeshi Oichi, Yuki Taniguchi, Kazuhito Soma, Song Ho Chang, Fumiko Yano, Sakae Tanaka, Taku Saito
STUDY DESIGN: Experimental study to develop a mouse model of lumbar intervertebral disc degeneration (IDD). OBJECTIVE: The aim of this study was to develop a mouse lumbar IDD model using surgically-induced instability and to compare the findings of this model to those in human IDD. SUMMARY OF BACKGROUND DATA: Previously, various kinds of inducers have been used to reproduce IDD in experimental animals; however, there is yet no standard mouse lumbar IDD model without direct injury to intervertebral disc...
October 9, 2017: Spine
https://www.readbyqxmd.com/read/28944904/triptolide-inhibits-proliferation-differentiation-and-induces-apoptosis-of-osteoblastic-mc3t3%C3%A2-e1-cells
#2
Wei Ji, Shijia Liu, Xia Zhao, Yunke Guo, Sha Xia, Yueyang Lu, Menyun Yin, Xiao Xu
Ankylosing spondylitis (AS) is characterized by the formation of bony spurs. Treatment of the resulting ankylosis, excessive bone formation and associated functional impairment, remain the primary therapeutic aims in research regarding this condition. Triptolide is the primary active component of the perennial vine Tripterygium wilfordii Hook. f., and has previously been demonstrated to exert anti‑tumor activities including inhibition of cell growth and the induction of apoptosis, however, the effect of triptolide on osteoblasts remains to be elucidated...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28929274/minimally-invasive-posterior-cervical-foraminotomy-for-treatment-of-radiculopathy-an-effective-time-tested-and-cost-efficient-motion-preservation-technique
#3
REVIEW
L Papavero, R Kothe
OBJECTIVE: To relieve foraminal root impingement due to lateral soft disc fragments, bony spurs, or other rarer causes. INDICATIONS: Soft disc fragment whose bulk is >2/3 lateral to the lateral border of the thecal sac. Intraforaminal dorsal bony narrowing of the root canal. Intraforaminal synovial cyst, extra/intradural tumor. CONTRAINDICATIONS: Paramedian and median soft/hard disc protrusions. Kyphosis of the index level. SURGICAL TECHNIQUE: Patient prone in reverse Trendelenburg position with the head fixed in a Mayfield clamp...
September 19, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28884053/pes-anserinus-bursitis-due-to-tibial-spurs-in-children
#4
Vivek Tiwari, Venkatesan Sampath Kumar, Rishi R Poudel, Ashok Kumar, Shah Alam Khan
Osteochondromas are the most common bone tumours. Although these tumors are relatively common in the long bones of children, the varied clinical and radiographic presentation of such neoplasms around the knee joint can cause diagnostic delays, especially when not associated with a palpable swelling. Proximal tibial osteochondromas can sometimes unusually present as spurs/ rose thorns leading to pes anserinus bursitis and vague knee pain. We describe the clinico-radiographic features of such proximal tibial metaphyseal osteochondromas giving rise to pes anserinus bursitis in three children, including bilaterally symmetrical osteochondroma in one of the cases, who were treated conservatively with good outcomes...
July 5, 2017: Curēus
https://www.readbyqxmd.com/read/28763161/monoallelic-fgfr3-and-biallelic-alpl-mutations-in-a-thai-girl-with-hypochondroplasia-and-hypophosphatasia
#5
Thantrira Porntaveetus, Chalurmpon Srichomthong, Kanya Suphapeetiporn, Vorasuk Shotelersuk
Skeletal dysplasias are a complex group of more than 350 disorders with phenotypic and genotypic heterogeneity affecting bone and cartilage growth. We studied a 2-year-old girl and her 21-year-old mother with disproportionate short stature. In addition to typical features of hypochondroplasia found in both patients, the child had deformities of the extremity bones, metaphyseal flares, and bilateral transverse (Bowdler) fibular spurs with overlying skin dimples detected at birth. Intravenous pamidronate was started in the child since the age of 17 days, and then every two months...
October 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28634056/a-new-and-accurate-predictive-model-for-the-efficacy-of-extracorporeal-shock-wave-therapy-in-managing-patients-with-chronic-plantar-fasciitis
#6
Mengchen Yin, Ni Chen, Quan Huang, Anastasia Sulindro Marla, Junming Ma, Jie Ye, Wen Mo
OBJECTIVES: To identify factors for the outcome of a minimum clinically successful therapy and to establish a predictive model of extracorporeal shock wave therapy (ESWT) in managing patients with chronic plantar fasciitis. DESIGN: Randomized controlled, prospective study. SETTING: Outpatient of local medical center settings. PARTICIPANTS: Patients treated for symptomatic chronic plantar fasciitis between 2014 and 2016 (N=278)...
June 17, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28373932/endoscopic-resection-of-dorsal-boss-of-the-second-and-third-tarsometatarsal-joints
#7
Tun Hing Lui
Dorsal boss of the foot also known as "tarsal boss," "dorsal exostosis," and "humped bone" is a bone spur that grows from one of the intertarsal or tarsometatarsal joints. It can occur with or without arthritis of the underlying joints. Surgery is indicated if the symptoms do not respond to conservative treatment. Excision of the dorsal boss with or without fusion of the underlying joint is the operative treatment of choice. We report an arthroscopic approach of resection of the dorsal exostosis. Arthroscopic arthrodesis if indicated can be performed through the same portals...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28369929/the-plantar-calcaneal-spur-a-review-of-anatomy-histology-etiology-and-key-associations
#8
REVIEW
Joshua Kirkpatrick, Omid Yassaie, Seyed Ali Mirjalili
The plantar calcaneal spur (PCS) is a bony outgrowth from the calcaneal tuberosity and has been studied using various methods including cadavers, radiography, histology and surgery. However, there are currently a number of discrepancies in the literature regarding the anatomical relations, histological descriptions and clinical associations of PCS. Historically, authors have described the intrinsic muscles of the foot and/or the plantar fascia as attaching to the PCS. In this article we review the relationship between the PCS and surrounding soft tissues as well as examining the histology of the PCS...
June 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28318055/menkes-disease-mimicking-child-abuse
#9
Rebecca J Droms, Jillian F Rork, Riley McLean, Madelena Martin, Leah Belazarian, Karen Wiss
Althouygh Menkes disease has well-recognized neurologic, developmental, and cutaneous features, the initial presentation may resemble child abuse. We describe a 5-month-old boy with multiple fractures indicative of nonaccidental trauma who was ultimately diagnosed with Menkes disease. Copper deficiency leads to connective tissue abnormalities and may result in subdural hematomas, wormian bones, cervical spine defects, rib fractures, and spurring of the long bone metaphyses. Several of these findings, including fractures and subdural hematomas, may be misinterpreted as child abuse...
May 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28287510/adsc-sheet-transplantation-to-prevent-stricture-after-extended-esophageal-endoscopic-submucosal-dissection
#10
Guillaume Perrod, Laetitia Pidial, Sophie Camilleri, Alexandre Bellucci, Amaury Casanova, Thomas Viel, Bertrand Tavitian, Chirstophe Cellier, Olivier Clément, Gabriel Rahmi
In past years, the cell-sheet construct has spurred wide interest in regenerative medicine, especially for reconstructive surgery procedures. The development of diversified technologies combining adipose tissue-derived stromal cells (ADSCs) with various biomaterials has led to the construction of numerous types of tissue-engineered substitutes, such as bone, cartilage, and adipose tissues from rodent, porcine, or human ADSCs. Extended esophageal endoscopic submucosal dissection (ESD) is responsible for esophageal stricture formation...
February 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28239212/nutritional-and-digestive-properties-of-protein-isolates-extracted-from-the-muscle-of-the-common-carp-using-ph-shift-processing
#11
Yuanyong Tian, Wei Wang, Chunhong Yuan, Long Zhang, Jinyang Liu, Junrong Liu
This study details the nutritional and digestive properties of protein isolates that are extracted from carp (Cyprinus Carpio L.) muscle using pH shifting methods. Alkaline (ALPI) and acid (ACPI) protein isolates exhibit higher protein yields (87.6%, 76.3%, respectively). In addition to the high recovery of myofibrillar protein, a portion of the water-soluble proteins is also recovered. The moisture contents of ACPI and ALPI are 85.5% and 88.5%, respectively, and the crude protein contents of these two fractions are 83...
February 2017: Journal of Food Processing and Preservation
https://www.readbyqxmd.com/read/28110469/is-diabetic-skeletal-fragility-associated-with-microvascular-complications-in-bone
#12
REVIEW
Roberto Jose Fajardo
PURPOSE OF REVIEW: The objective of this literature review is to determine whether there are indications that microvascular complications occur in diabetic bone. Evidence definitively linking diabetic skeletal fragility with microvascular complications in bone remains elusive. RECENT FINDINGS: Circumstantial evidence, some recent and some lost to time, suggests that atherosclerotic vascular diseases such as peripheral arterial disease cause poor blood perfusion of bone and subsequent hypoxia and contribute to low bone density and high cortical porosity, patterns similar to some recently observed in diabetic subjects...
February 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/27684082/intraobserver-reliability-and-interobserver-agreement-in-radiographic-classification-of-heterotopic-ossification
#13
Georgios I Vasileiadis, Yodhiaki Itoigawa, Derek F Amanatullah, Luis Pulido-Sierra, Jeremy R Crenshaw, Christine Huyber, Michael J Taunton, Kenton R Kaufman
The most widely used radiologic classification system for heterotopic ossification after total hip arthroplasty (THA) is the Brooker scale. In 2002, Della Valle et al proposed a modified rating system for heterotopic ossification to increase intraobserver reliability and interobserver agreement. To date, no study comparing these 2 classification systems has been conducted. Moreover, these studies were grossly underpowered. In the current study, 3 clinicians reviewed the charts of 236 patients with documented radiographic heterotopic ossification at least 2 months after THA and independently graded the amount of heterotopic ossification according to the Brooker and Della Valle classification systems...
January 1, 2017: Orthopedics
https://www.readbyqxmd.com/read/27680702/xpo1-dependent-nuclear-export-is-a-druggable-vulnerability-in-kras-mutant-lung-cancer
#14
Jimi Kim, Elizabeth McMillan, Hyun Seok Kim, Niranjan Venkateswaran, Gurbani Makkar, Jaime Rodriguez-Canales, Pamela Villalobos, Jasper Edgar Neggers, Saurabh Mendiratta, Shuguang Wei, Yosef Landesman, William Senapedis, Erkan Baloglu, Chi-Wan B Chow, Robin E Frink, Boning Gao, Michael Roth, John D Minna, Dirk Daelemans, Ignacio I Wistuba, Bruce A Posner, Pier Paolo Scaglioni, Michael A White
The common participation of oncogenic KRAS proteins in many of the most lethal human cancers, together with the ease of detecting somatic KRAS mutant alleles in patient samples, has spurred persistent and intensive efforts to develop drugs that inhibit KRAS activity. However, advances have been hindered by the pervasive inter- and intra-lineage diversity in the targetable mechanisms that underlie KRAS-driven cancers, limited pharmacological accessibility of many candidate synthetic-lethal interactions and the swift emergence of unanticipated resistance mechanisms to otherwise effective targeted therapies...
October 6, 2016: Nature
https://www.readbyqxmd.com/read/27648196/insight-on-bone-morphogenetic-protein-7-in-ankylosing-spondylitis-and-its-association-with-disease-activity-and-radiographic-damage
#15
Adel Mahmoud, Dalia Fayez, Mervat Mammdouh Abou Gabal, Sherin Mohamed Hosny Hamza, Takwa Badr
INTRODUCTION: Fusion of joints as well as intervertebral spaces by the formation of bony spurs appearing as syndesmophytes and osteophytes are the hallmark of spondyloarthropathies which accounts for disability. The aim of this study was to assess the serum level of bone morphogenetic protein (BMP)-7 in ankylosing spondylitis and its relationship with disease activity and the radiographic damage. METHODS: This longitudinal case control study was conducted in Ain Shams University Hospitals (Egypt)...
July 2016: Electronic Physician
https://www.readbyqxmd.com/read/27617828/heel-spur-and-acupuncture-does-it-work
#16
A E Sahin, Y Cayir, A Imerci, H Uzkeser, F Akcay
Heel spur is also known as a result of plantar calcaneal bone spur which is a common complaint associated with pain at heel. Heel spur is more common in females. Anti-inflammatory drugs, local steroid injections, physical therapy, low-dose radiotherapy and shock wave therapy are the commonly used treatment choices. There is no evidence that acupuncture is an effective method for heel spur in the literature. However, we know that acupuncture can be used for many orthopaedic diseases like frozen shoulder, tennis elbow, sciatic pain, joint sprains, several forms of bursitis and arthritis...
November 11, 2015: West Indian Medical Journal
https://www.readbyqxmd.com/read/27600060/in-silico-bone-mechanobiology-modeling-a-multifaceted-biological-system
#17
REVIEW
Mario Giorgi, Stefaan W Verbruggen, Damien Lacroix
Mechanobiology, the study of the influence of mechanical loads on biological processes through signaling to cells, is fundamental to the inherent ability of bone tissue to adapt its structure in response to mechanical stimulation. The immense contribution of computational modeling to the nascent field of bone mechanobiology is indisputable, having aided in the interpretation of experimental findings and identified new avenues of inquiry. Indeed, advances in computational modeling have spurred the development of this field, shedding new light on problems ranging from the mechanical response to loading by individual cells to tissue differentiation during events such as fracture healing...
November 2016: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/27579849/multimodality-imaging-review-of-the-post-amputation-stump-pain
#18
REVIEW
Nawaraj Subedi, Priam Heire, Vinay Parmer, Simon Beardmore, Chooi Oh, Fergus Jepson, Syed I Ali
Limb amputation is one of the oldest known surgical procedures performed for a variety of indications. Little surgical technical improvements have been made since the first procedure, but perioperative and post-operative refinements have occurred over time. Post-amputation pain (PAP) of the stump is a common complication but is an extremely challenging condition to treat. Imaging allows early diagnosis of the underlying cause so that timely intervention is possible to minimize physical disability with its possible psychological and socioeconomic implications...
December 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27423433/the-simultaneous-occurrence-of-histoplasmosis-and-cryptococcal-fungemia-a-case-report-and-review-of-the-literature
#19
REVIEW
Joslaine de Oliveira Nunes, Kelly Regina Alves Pereira Pillon, Patrícia Lira Bizerra, Anamaria Mello Miranda Paniago, Rinaldo Poncio Mendes, Marilene Rodrigues Chang
Simultaneous infections with Cryptococcus neoformans and Histoplasma capsulatum are rare and typically occur in immunocompromised individuals, particularly AIDS patients. Because both of those fungi can spur the development of latent infections, it is generally unknown which organism was first present. The diagnosis of one fungus can hide the diagnosis of the other, leading to underdiagnoses and poor prognosis. We report a case of C. neoformans and H. capsulatum co-infection. We also performed a systematic review of the literature...
December 2016: Mycopathologia
https://www.readbyqxmd.com/read/27236673/isolation-of-mouse-bone-marrow-mesenchymal-stem-cells
#20
Siddaraju V Boregowda, Veena Krishnappa, Donald G Phinney
Mesenchymal stem cells (MSCs) were initially characterized as connective tissue progenitors resident in bone marrow, but have now been isolated from a variety of tissues and organs and shown to also exhibit potent tissue regenerative properties mediated largely via paracrine actions. These findings have spurred the development of MSC-based therapies for treating a diverse array of nonskeletal diseases. Although genetic and experimental rodent models of disease represent important tools for developing efficacious MSC-based therapies, development of reliable methods to isolate MSCs from mouse bone marrow has been hampered by the unique biological properties of these cells...
2016: Methods in Molecular Biology
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