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Oligometastases

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https://www.readbyqxmd.com/read/29324212/managing-patients-with-oligometastatic-non-small-cell-lung-cancer
#1
Sarah Jo Stephens, Michael J Moravan, Joseph K Salama
Metastatic lung cancer has long been considered incurable, with the goal of treatment being palliation. However, a clinically meaningful number of these patients with limited metastases (approximately 25%) are living long term after definitive treatment to all sites of active disease. These patients with so-called oligometastatic disease likely represent a distinct clinical group who may possess a more indolent biology compared with their more widely metastatic counterparts. Hellman and Weichselbaum proposed the existence of the oligometastatic state, on the basis of the spectrum theory of cancer spread...
January 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29280465/prostate-specific-membrane-antigen-positron-emission-tomography-computed-tomography-for-prostate-cancer-distribution-of-disease-and-implications-for-radiation-therapy-planning
#2
Sandeep K Gupta, Tahne Watson, Jim Denham, Thomas P Shakespeare, Natalie Rutherford, Nicholas McLeod, Kevin Picton, Paul Ainsworth, Tony Bonaventura, Jarad M Martin
PURPOSE: To explore the prostate-specific membrane antigen (PSMA)-avid distribution of prostate cancer (PC) on positron emission tomography (PET), both at the time of initial diagnosis and at the time of relapse after definitive local treatment. METHODS AND MATERIALS: A total of 179 PSMA PET scans in patients with nil or ≤3 lesions on conventional imaging were retrospectively categorized into 3 subgroups: group A, high-risk PC with no prior definitive therapy (n=34); group B, prior prostatectomy (n=75); and group C, prior radiation therapy (n=70)...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29275824/predictors-of-survival-after-treatment-of-oligometastases-after-esophagectomy
#3
Galal Ghaly, Sebron Harrison, Mohamed K Kamel, Mohamed Rahouma, Abu Nasar, Jeffrey L Port, Brendon M Stiles, Nasser K Altorki
BACKGROUND: Recurrent esophageal carcinoma (EC) has a dismal prognosis. However, prior studies showed that selected patients with isolated recurrence may benefit from definitive therapy. The aim of this study was to identify the predictors of postrecurrence survival (PRS) in patients with isolated EC recurrence who were treated with curative intent. METHODS: A retrospective review of a prospective database (1988 to 2015) was performed to identify all recurrent EC patients after curative esophagectomy...
December 21, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29225693/cytoreductive-prostate-radiotherapy-in-oligometastatic-prostate-cancer-a-single-centre-analysis-of-toxicity-and-clinical-outcome
#4
Giulia Riva, Giulia Marvaso, Matteo Augugliaro, Dario Zerini, Cristiana Fodor, Gennaro Musi, Ottavio De Cobelli, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Objectives: The current standard of care for patients with metastatic prostate cancer (mPCa) at diagnosis is androgen deprivation therapy (ADT) with or without anti-androgen and chemotherapy. The aim of this study was to define the role of a local radiotherapy (RT) treatment in the mPCa setting. Methods: We retrospectively reviewed data of patients with PCa and bone oligometastases at diagnosis treated in our institution with ADT followed by cytoreductive prostate-RT with or without RT on metastases...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29224900/single-fraction-stereotactic-ablative-body-radiotherapy-for-oligometastasis-outcomes-from-132-consecutive-patients
#5
S Gandhidasan, D Ball, T Kron, M Bressel, M Shaw, J Chu, S Chander, G Wheeler, N Plumridge, B Chesson, S David, S Siva
AIMS: Stereotactic ablative body radiotherapy (SABR) is currently used to treat oligometastases, but the optimum dose/fractionation schedule is unknown. In this study, we evaluated outcomes after single fraction SABR in patients with oligometastatic disease. MATERIALS AND METHODS: Single institutional retrospective review of patients treated with single fraction SABR for one to three oligometastases between 2010 and 2015. The primary outcome was freedom from widespread disease defined as distant recurrence not amenable to surgery or SABR; or recurrence with four or more metastases...
December 7, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29191586/outcome-of-radical-local-treatment-of-non-small-cell-lung-cancer-patients-with-synchronous-oligometastases
#6
Margriet Kwint, Iris Walraven, Sjaak Burgers, Koen Hartemink, Houke Klomp, Joost Knegjens, Marcel Verheij, José Belderbos
OBJECTIVES: Patients with stage IV non-small cell lung cancer (NSCLC) are considered incurable and are mainly treated with palliative intent. This patient group has a poor overall survival (OS) and progression free survival (PFS). The purpose of this study was to investigate PFS and OS of NSCLC patients diagnosed with synchronous oligometastatic disease who underwent radical treatment of both intrathoracic disease and metastases. MATERIALS AND METHODS: Patients with NSCLC and oligometastatic disease at diagnosis, who were treated with radical intent between 2008 and 2016, were included in this observational study...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29181556/oligometastases-in-prostate-cancer-metabolic-response-in-follow-up-psma-pet-cts-after-hypofractionated-igrt
#7
René Baumann, Mark Koncz, Ulf Luetzen, Fabian Krause, Juergen Dunst
BACKGROUND: Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMAPET/CT) is a new and evolving diagnostic method in prostate cancer with special impact on treatment planning in image-guided radiotherapy (IGRT). Initial results of metabolic response in repeated PSMA PET/CTs after hypofractionated IGRT for metastatic lesions are reported here. MATERIALS AND METHODS: Of 280 patients investigated with 68Ga-PSMA PET/CT in the period from 01/2014 through 12/2016 in the authors' department, patients were selected according to the following criteria: oligometastatic disease at initial PSMA PET/CT defined as not more than five metastatic lesions, hypofractionated IGRT to all lesions, no systemic therapy in the last 6 months and during follow-up, and at least one follow-up PSMA PET after radiotherapy...
November 27, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29155507/the-role-of-radiation-therapy-in-the-modern-management-of-oligometastatic-disease
#8
Yan Li, Suyu Tao, Mengru Li, Duojie Li
Multimodal treatment approaches are indispensable for patients with advanced-stage cancer, while radiation therapy has been established as essential part of therapeutic approaches and has been introduced as a better option to face challenges, such as, local relapse or oligometastatic disease. The mere insight of the concept of oligometastases, proposed for the first time in the middle 1990s, led to the hypothesis that this condition may be cured using local ablative weapons. This hypothesis has already been demonstrated by surgical ablative techniques...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29147583/patterns-of-progression-in-metastatic-estrogen-receptor-positive-breast-cancer-an-argument-for-local-therapy
#9
Patrick Kelly, Zhe Ma, Said Baidas, Rebecca Moroose, Nikita Shah, Roi Dagan, Eleftherios Mamounas, Justin Rineer
Purpose: Despite advances in endocrine therapy (ET), metastatic estrogen receptor positive breast cancer (BrCA) remains incurable. Though the mechanisms of resistance to ET have been studied extensively, the anatomic pattern of disease progression remains poorly characterized. The purpose of this study was to characterize the pattern of progression for patients receiving ET for metastatic BrCA. Methods: The records of 108 patients with metastatic BrCA who progressed on ET were reviewed...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29129384/radiofrequency-ablation-for-hepatic-oligometastatic-pancreatic-cancer-an-analysis-of-safety-and-efficacy
#10
Yong-Qiang Hua, Peng Wang, Xiao-Yan Zhu, Ye-Hua Shen, Kun Wang, Wei-Dong Shi, Jun-Hua Lin, Zhi-Qiang Meng, Zhen Chen, Hao Chen
OBJECTIVES: This study was to evaluate the value of radiofrequency ablation (RFA) in the treatment of pancreatic cancer with synchronous liver oligometastasis. METHODS: 102 patients diagnosed with pancreatic cancer with synchronous liver oligometastasis undergoing RFA were recruited in this retrospective study between January 2012 and December 2015. Clinical efficacy was evaluated by computed tomography or magnetic resonance imaging 1 month later. All patients were treated with RFA and systemic chemotherapy based on NCCN guideline...
September 1, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29128882/early-recurrence-in-patients-undergoing-curative-resection-of-colorectal-liver-oligometastases-identification-of-its-clinical-characteristics-risk-factors-and-prognosis
#11
Junzhong Lin, Jianhong Peng, Yixin Zhao, Baojia Luo, Yujie Zhao, Yuxiang Deng, Qiaoqi Sui, Yuanhong Gao, Zhifan Zeng, Zhenhai Lu, Zhizhong Pan
PURPOSE: Oligometastatic disease can potentially be cured when an optimal approach is performed. Early recurrence after liver resection is an intractable problem, and the clinical implications remain unknown in colorectal liver oligometastases (CLOM) patients. This study aimed to investigate the clinical characteristics, risk factors, and prognosis related to early recurrence in these patients. METHODS: A total of 307 consecutive patients with CLOM undergoing curative liver resection were retrospectively reviewed between September 1999 and June 2016...
November 11, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29078678/uniportal-non-intubated-lung-metastasectomy
#12
Tommaso Claudio Mineo, Francesco Sellitri, Eleonora Fabbi, Vincenzo Ambrogi
BACKGROUND: More than 15 years ago, we started a program of uniportal video-assisted thoracoscopies (VATS) lung metastasectomy in non-intubated local anesthesia. Hereby we present the short and long-term results of this combined surgical-anesthesiological technique. METHODS: Between 2005 and 2015, 71 patients (37 men and 34 women) with pulmonary oligometastases, at the first episode, underwent uniportal VATS metastasectomy under non-intubated anesthesia. RESULTS: Four patients (5...
2017: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29066674/-treatment-strategy-in-patients-with-oligometastatic-breast-cancer
#13
Masataka Sawaki, Hiroji Iwata
Oligometastases means the state which the anatomy and physiology may limit or concentrate metastases to a single or a limited number of organs. In patients with oligometastatic breast cancer their prognosis may be good, although the impact of local therapy has not been evaluated prospectively. The development of minimally invasive surgical techniques and highly conformal ablative radiotherapy allow for safe and effective ablation of metastatic lesions in most locations. A biopsy(preferably providing histology)of a metastatic lesion has been recommended to confirm diagnosis particularly when metastasis is diagnosed for the first time...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28958106/-stereotactic-body-radiotherapy-for-early-stage-nsclc-what-is-the-evidence
#14
Matthias Guckenberger
Stereotactic body radiotherapy (SBRT) was first described in the mid 90s as a technique using high precision radiotherapy to deliver escalated, ablative irradiation doses and which simultaneously minimised incidental irradiation of healthy tissue. Technological and clinical development of this technique has been pioneered in the field of early stage non-small cell lung cancer, where improved local tumor control led to prolonged overall survival. Today, SBRT is the evidence-based and guideline-recommended treatment of choice for early stage NSCLC in patients who are medically inoperable...
September 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28920500/acute-toxicity-of-the-bowel-after-stereotactic-robotic-radiotherapy-for-abdominopelvic-oligometastases
#15
Michael Frelinghuysen, Wilco Schillemans, Lieke Hol, Cornelis Verhoef, Mischa Hoogeman, Joost Jan Nuyttens
AIM: To correlate dose-volume histogram (DVH) parameters with appearance of grade ≥2 acute and late gastrointestinal toxicity of stereotactic body radiotherapy (SBRT) in patients with abdominopelvic solitary or oligometastatic disease outside the liver. MATERIAL AND METHODS: Acute and late bowel toxicity of 84 abdominopelvic oligometastatic patients was registered. A logistic regression was performed between different DVH parameters and presence of grade ≥2 acute and late toxicity...
September 18, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28917254/stereotactic-radiotherapy-in-oligometastatic-cancer
#16
Thomas A C Kennedy, Mark T Corkum, Alexander V Louie
Oligometastatic cancer describes a disease state somewhere between localized and metastatic cancer. Proposed definitions of oligometastatic disease have typically used a cut-off of five or fewer sites of disease. Treatment of oligometastatic disease should have the goal of long-term local control, and in selected cases, disease remission. While several retrospective cohorts argue for surgical excision of limited metastases (metastasectomy) as the preferred treatment option for several clinical indications, limited randomized data exists for treating oligometastases...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28917250/emerging-technologies-in-stereotactic-body-radiotherapy
#17
Lijun Ma, Lei Wang, Chia-Lin Tseng, Arjun Sahgal
Stereotactic body radiation therapy (SBRT) stems from the initial developments of intra-cranial stereotactic radiosurgery (SRS). Despite similarity in their names and clinical goals of delivering a sufficiently high tumoricidal dose, maximal sparing of the surrounding normal tissues and a short treatment course, SBRT technologies have transformed from the early days of body frame-based treatments with X-ray verification to primarily image-guided procedures with cone-beam CT or stereoscopic X-ray systems and non-rigid body immo-bilization...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28838708/local-therapy-for-pulmonary-oligometastases-is-sabr-a-new-champion
#18
EDITORIAL
Young Tae Kim
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28835666/thoracic-radiotherapy-trt-improved-survival-in-both-oligo-and-polymetastatic-extensive-stage-small-cell-lung-cancer
#19
Li-Ming Xu, Chingyun Cheng, Minglei Kang, Jing Luo, Lin-Lin Gong, Qing-Song Pang, Jun Wang, Zhi-Yong Yuan, Lu-Jun Zhao, Ping Wang
There has been no previous study on the efficacy of the thoracic radiotherapy (TRT) in oligometastatic or polymetastatic extensive stage small-cell lung cancer (ES-SCLC) to the overall survival (OS). In a group of 270 ES-SCLC cases retrospective study, 78 patients (28.9%) had oligometastases and 192 (71.1%) had polymetastases, among which 51 oligometastatic patients (65.4%) and 93 polymetastatic patients (51.6%) received TRT. Propensity score matching (PSM) was utilized. The 2-year OS, progression free survival (PFS) and local control (LC) in oligometastatic and polymetastatic patients were 22...
August 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28834084/does-robot-assisted-radical-prostatectomy-benefit-patients-with-prostate-cancer-and-bone-oligometastases
#20
Won Sik Jang, Myung Soo Kim, Won Sik Jeong, Ki Don Chang, Kang Su Cho, Won Sik Ham, Koon Ho Rha, Sung Joon Hong, Young Deuk Choi
OBJECTIVE: To investigate the peri-operative and oncological outcomes of robot-assisted radical prostatectomy (RARP) in patients with oligometastatic prostate cancer (PCa). PATIENTS AND METHODS: We retrospectively reviewed the records of 79 patients with oligometastatic PCa treated with RARP or androgen deprivation therapy (ADT) between 2005 and 2015 at our institution. Of these 79 patients, 38 were treated with RARP and 41 were treated with ADT without local therapy...
August 21, 2017: BJU International
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