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Oligometastases

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https://www.readbyqxmd.com/read/28275472/uniportal-video-assisted-thoracic-surgery-colorectal-lung-metastasectomy-in-non-intubated-anesthesia
#1
Vincenzo Ambrogi, Francesco Sellitri, Gianluca Perroni, Orazio Schillaci, Tommaso Claudio Mineo
BACKGROUND: More than ten years ago we started a program of video-assisted thoracic surgery (VATS) lung metastasectomy in non-intubated local anesthesia. In this study we investigated the effectiveness and long term results of this combined surgical-anesthesiological technique. METHODS: Between 2005 and 2014, 48 patients (25 men and 23 women) with pulmonary oligometastases from colorectal cancer, at the first episode, underwent VATS metastasectomy under non-intubated local anesthesia...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28237869/the-role-of-image-guided-therapy-in-the-management-of-colorectal-cancer-metastatic-disease
#2
REVIEW
Thierry de Baere, Lambros Tselikas, Steven Yevich, Valérie Boige, Frederic Deschamps, Michel Ducreux, Diane Goere, France Nguyen, David Malka
The European Society for Medical Oncology (ESMO) have stressed that the option for treating oligometastatic disease is a strategy of local ablative therapy, the goal of which is to improve disease control. The spectrum of the local ablative therapy toolbox described by the ESMO includes surgical R0 resection, percutaneous ablation and intra-arterial therapies, the choice of treatment being left to the multidisciplinary team. Interventional therapy involving image-guided treatment offers the possibility of less invasive treatments for colorectal cancer metastases in the liver, lung and bone by preserving from toxicity distant healthy organs or even parts of the diseased organs...
February 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28237218/stereotactic-ablative-body-radiotherapy-for-the-treatment-of-spinal-oligometastases
#3
J H Chang, S Gandhidasan, R Finnigan, D Whalley, R Nair, A Herschtal, T Eade, A Kneebone, J Ruben, M Foote, S Siva
AIMS: To report multicentre outcomes of patients with spinal oligometastases treated with stereotactic ablative body radiotherapy (SABR). The primary objective was to estimate the widespread failure-free survival (WFFS) at 2 years - defined as freedom from metastases not amenable to local salvage therapy and death. MATERIALS AND METHODS: Patients with one to three metastases treated with spinal SABR between January 2010 and July 2014 at four academic institutions were included in this retrospective review...
February 22, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28152619/a-multinational-report-of-technical-factors-on-stereotactic-body-radiotherapy-for-oligometastases
#4
Kristin J Redmond, Simon S Lo, Roi Dagan, Ian Poon, Matthew C Foote, Darby Erler, Young Lee, Frank Lohr, Tithi Biswas, Umberto Ricardi, Arjun Sahgal
AIM: Oligometastatic cancer is being increasingly managed with aggressive local therapy using stereotactic body radiation therapy (SBRT). However, few guidelines exist. We summarize the results of an international survey reviewing technical factors for extracranial SBRT for oligometastatic disease to guide safe management. MATERIALS & METHODS: Seven high-volume centers contributed. Levels of agreement were categorized as strong (6-7 common responses), moderate (4-5), low (2-3) or no agreement...
February 3, 2017: Future Oncology
https://www.readbyqxmd.com/read/28148271/surgical-treatment-in-non-small-cell-lung-cancer-with-pulmonary-oligometastasis
#5
Jinyuan He, Yun Li, Jun An, Liu Hu, Junhang Zhang
BACKGROUND: Previous studies have demonstrated survival benefits for local treatment in solitary metastatic non-small cell lung cancer (NSCLC).This study aimed to investigate the effect of local surgery for NSCLC with pulmonary oligometastasis. METHODS: This study included 21 patients of NSCLC with pulmonary oligometastasis between January 2003 and December 2013, which were divided into two groups, group A (11 cases) for local surgery and group B (10 cases) for systematic chemotherapy, compared the median survival time (MST) and 5-year survival rate between the two groups, and analyzed the impact of the pathological types, the TNM and pN stage of primary tumor, the site, and the mode and number of oligometastatic nodule on group A...
February 2, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28138949/stereotactic-body-radiotherapy-sbrt-in-recurrent-or-oligometastatic-pancreatic-cancer-a%C3%A2-toxicity-review-of-simultaneous-integrated-protection-sip-versus-conventional-sbrt
#6
E Gkika, S Adebahr, S Kirste, T Schimek-Jasch, R Wiehle, R Claus, U Wittel, U Nestle, D Baltas, A L Grosu, T B Brunner
BACKGROUND: Stereotactic body radiotherapy (SBRT) in pancreatic cancer can be limited by its proximity to organs at risk (OAR). In this analysis, we evaluated the toxicity and efficacy of two different treatment approaches in patients with locally recurrent or oligometastatic pancreatic cancer. MATERIALS AND METHODS: According to the prescription method, patients were divided in two cohorts (C1 and C2). The planning target volume (PTV) was created through a 4 mm expansion of the internal target volume...
January 30, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28126325/stereotactic-ablative-radiation-therapy-for-lung-oligometastases-predictive-parameters-of-early-response-by-18-fdg-pet-ct
#7
Rosario Mazzola, Alba Fiorentino, Gioacchino Di Paola, Niccolò Giaj Levra, Francesco Ricchetti, Sergio Fersino, Umberto Tebano, Stefano Pasetto, Ruggero Ruggieri, Matteo Salgarello, Filippo Alongi
OBJECTIVES: The objective of this study was to investigate fludeoxyglucose F 18 positron emission tomography/computed tomography ((18)FDG-PET/CT) parameters as predictive of response after stereotactic ablative radiotherapy (SABR) for lung oligometastases. METHODS: The inclusion criteria of the current retrospective study were as follows: (1) lung oligometastases treated by SABR, (2) presence of (18)FDG-PET/CT before and after SABR for at least two subsequent evaluations, (3) Karnofsky performance status higher than 80, and (4) life expectancy longer than 6 months...
March 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28054139/-local-ablative-radiotherapy-of-oligometastatic-colorectal-cancer
#8
C Petersen, T Gauer
BACKGROUND: Colorectal cancer (CRC) often presents as oligometastatic disease. Currently available intensive systemic treatment regimens, including combination chemotherapy and molecular targeted agents, result in tumor response and transient to long-term disease control in a high percentage of patients, thus raising the question of further management. Secondary resection and ablation, e.g. by surgery or radiofrequency may contribute to long-term survival and even be curative or at least allow a relevant chemotherapy-free interval...
February 2017: Der Radiologe
https://www.readbyqxmd.com/read/28050151/eastern-canadian-gastrointestinal-cancer-consensus-conference-2016
#9
D Bossé, T Ng, C Ahmad, A Alfakeeh, I Alruzug, J Biagi, J Brierley, P Chaudhury, S Cleary, B Colwell, C Cripps, L A Dawson, M Dorreen, E Ferland, P Galiatsatos, S Girard, S Gray, F Halwani, N Kopek, A Mahmud, G Martel, L Robillard, B Samson, M Seal, J Siddiqui, L Sideris, S Snow, M Thirwell, M Vickers, R Goodwin, R Goel, T Hsu, E Tsvetkova, B Ward, T Asmis
The annual Eastern Canadian Gastrointestinal Cancer Consensus Conference 2016 was held in Montreal, Quebec, 5-7 February. Experts in radiation oncology, medical oncology, surgical oncology, and infectious diseases involved in the management of patients with gastrointestinal malignancies participated in presentations and discussion sessions for the purpose of developing the recommendations presented here. This consensus statement addresses multiple topics: ■ Follow-up and survivorship of patients with resected colorectal cancer■ Indications for liver metastasectomy■ Treatment of oligometastases by stereotactic body radiation therapy■ Treatment of borderline resectable and unresectable pancreatic cancer■ Transarterial chemoembolization in hepatocellular carcinoma■ Infectious complications of antineoplastic agents...
December 2016: Current Oncology
https://www.readbyqxmd.com/read/28048465/su-f-t-591-sbrt-treatment-of-multiple-extracranial-oligometastases-using-a-single-isocenter-with-distinct-optimizations-sido
#10
M Trager, J Adamson, J Salama
PURPOSE: A new development in linac-based intracranial radiosurgery is treatment of multiple targets using single isocenter VMAT, which dramatically reduces treatment time while maintaining high conformality and dose gradient. Our purpose is to translate this technique to extracranial SBRT of oligometastases and address additional challenges such as interplay from motion and setup uncertainties. METHODS: We propose SIDO (Single Isocenter with Distinct Optimizations) planning in which all VMAT arcs share an isocenter but each arc treats only one target...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28011508/stereotactic-body-radiotherapy-in-patients-with-lung-oligometastases-from-colorectal-cancer
#11
Francesco Pasqualetti, Sabrina Montrone, Caterina Vivaldi, Margherita Zani, David Fedele, Lorenzo Fornaro, Giuseppe Pasqualetti, Lisa Salvatore, Bruno Manfredi, Concetta Laliscia, Gabriele Coraggio, Alessandra Gonnelli, Fotios Loupakis, Gianluca Masi, Aldo Sainato, Fabio Monzani, Alfredo Falcone, Fabiola Paiar
AIM: To assess the role of stereotactic body radiotherapy (SBRT) in pulmonary metastases from colorectal cancer (CRC). PATIENTS AND METHODS: Thirty-three consecutive patients with pulmonary metastases from CRC who received SBRT were included in the analysis. The primary endpoints were local and systemic progression-free survival, a secondary endpoint was the safety profile of SBRT. RESULTS: A total of 56 lesions were treated with SBRT. A single nodule was treated in 15 patients, two in 13 and three in five...
2017: Anticancer Research
https://www.readbyqxmd.com/read/27914779/what-do-radiation-oncologists-require-for-future-advancements-in-lung-sbrt
#12
REVIEW
Umberto Ricardi, Serena Badellino, Andrea Riccardo Filippi
Stereotactic Body Radiotherapy (SBRT) is a well established therapeutic option for patients affected with peripheral early stage non-small cell lung cancer (NSCLC), given the positive clinical evidence accumulated so far on its efficacy and safety. SBRT is regarded as the best choice for inoperable patients, and could also be offered as an alternative to surgery to selected operable patients. More recently, its use for lung metastases progressively increased, and SBRT is now regarded as a low toxic and highly effective local therapy for lung oligometastases from different primary tumors, especially colorectal cancer...
November 30, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27889195/metastasectomy-in-cutaneous-melanoma
#13
REVIEW
K Lasithiotakis, O Zoras
Metastasectomy remains the only treatment in malignant melanoma to offer complete pathologic response within a few days of in-hospital stay. It has been historically associated with the highest survival rates in the literature reported for patients of this stage. However, only a minority of patients are amenable to curative resection of distant metastatic disease. This patient group exhibit slow growing oligometastases as indicated by: a. Long disease free interval after treatment of their primary tumours and b...
March 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27886588/the-expanding-role-of-stereotactic-body-radiation-therapy-in-oligometastatic-solid-tumors-what-do-we-know-and-where-are-we-going
#14
REVIEW
Julian C Hong, Joseph K Salama
The spectrum hypothesis posits that there are distinct clinical states of metastatic progression. Early data suggest that aggressive treatment of more biologically indolent metastatic disease, characterized by metastases limited in number and destination organ, may offer an opportunity to alter the disease course, potentially allowing for longer survival, delay of systemic therapy, or even cure. The development of stereotactic body radiation therapy (SBRT) has opened new avenues for the treatment of oligometastatic disease...
January 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27870683/increasing-role-of-image-guided-ablation-in-the-treatment-of-musculoskeletal-tumors
#15
Anil Nicholas Kurup, Matthew R Callstrom
In the last decade, percutaneous treatment of musculoskeletal (MSK) tumors has become more established in routine clinical care while also undergoing a number of advancements. Ablative techniques to palliate painful skeletal metastases have gained wide acceptance, while goals for ablation have evolved to include local control of oligometastases and desmoid tumors. Bone consolidation or augmentation is now frequently used in conjunction with or instead of ablation of skeletal tumors to stabilize pathologic fractures or prevent further morbidity that could result from fractures caused by tumor progression...
November 2016: Cancer Journal
https://www.readbyqxmd.com/read/27867922/palliative-resection-of-metastatic-brain-tumors-previously-treated-by-stereotactic-radiosurgery
#16
Yoo Sung Jeon, Young-Cho Koh, Sang Woo Song, Joon Cho, So Dug Lim
BACKGROUND: Therapeutic approaches to brain metastases include surgery, whole-brain radiotherapy, stereotactic radiosurgery (SRS), and combination therapy. Recently, postoperative or preoperative SRS draws more attention to reduce postoperative recurrence in brain metastases. The goal of this study is to review surgical outcome of patients who had been treated by SRS, and to discuss the effectiveness of preoperative SRS. METHODS: From 2009 to 2015, 174 patients were treated by SRS for brain metastases, and among these 50 patients underwent surgery...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867636/oligometastases-to-the-liver-predicting-outcomes-based-upon-radiation-sensitivity
#17
COMMENT
Haoming Qiu, Alan W Katz, Michael T Milano
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27867337/oligometastatic-growing-teratoma-syndrome-a-case-for-an-aggressive-surgical-approach
#18
William S Gange, Robert H Blackwell, John Biemer, Güliz A Barkan, Maria M Picken, Marcus L Quek
Growing teratoma syndrome is an infrequent presentation of testicular cancer. We present a case of growing teratoma syndrome in a patient who initially presented with clinical stage I nonseminomatous testicular germ cell tumor, who subsequently developed large volume oligometastases to the retroperitoneum, thorax, and thigh. Despite two regimens of chemotherapy, his disease progressed. Complete surgical extirpation of all gross tumors confirmed mature teratoma. An aggressive surgical approach, including postchemotherapy resection of all known metastatic sites, can provide long-term disease-free survival...
October 2016: Current Urology
https://www.readbyqxmd.com/read/27843034/intensity-modulated-radiation-therapy-with-simultaneous-integrated-boost-in-patients-with-brain-oligometastases-a-phase-1-study-iside-bm-1
#19
Marica Ferro, Silvia Chiesa, Gabriella Macchia, Savino Cilla, Federica Bertini, Giovanni Frezza, Andrea Farioli, Silvia Cammelli, Mario Balducci, Anna Ianiro, Anna Lisa Angelini, Gaetano Compagnone, Vincenzo Valentini, Francesco Deodato, Alessio G Morganti
PURPOSE: To investigate the maximum tolerated dose of intensity modulated radiation therapy simultaneous integrated boost whole-brain radiation therapy for palliative treatment of patients with <5 brain metastases using a standard linear accelerator. MATERIALS AND METHODS: The whole brain plus 3-mm margin was defined as the planning target volume (PTVwb), whereas each brain metastasis, defined as the contrast-enhancing tumor on MRI T1 scans, plus a 3-mm isotropic margin, was defined as metastases PTV (PTVm)...
January 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27796820/whole-body-diffusion-weighted-magnetic-resonance-imaging-wb-dw-mri-vs-choline-positron-emission-tomography-computed-tomography-choline-pet-ct-for-selecting-treatments-in-recurrent-prostate-cancer
#20
A J Conde-Moreno, G Herrando-Parreño, R Muelas-Soria, J Ferrer-Rebolleda, R Broseta-Torres, M P Cozar-Santiago, F García-Piñón, C Ferrer-Albiach
OBJECTIVE: To determine the effectiveness of whole-body diffusion-weighted magnetic resonance imaging (WB-DW-MRI) in detecting metastases by comparing the results with those from choline-positron emission tomography-computed tomography (choline-PET/CT) in patients with biochemical relapse after primary treatment, and no metastases in bone scintigraphy, CT and/or pelvic MRI, or metastatic/oligometastatic prostate cancer (PCa). Patients with this disease profile who could benefit from treatment with stereotactic body radiation therapy (SBRT) were selected and their responses to these techniques were rated...
October 31, 2016: Clinical & Translational Oncology
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