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Oligometastases

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https://www.readbyqxmd.com/read/28807235/stereotactic-ablative-radiation-therapy-in-renal-cell-carcinoma-from-oligometastatic-to-localized-disease
#1
REVIEW
Filippo Alongi, Stefano Arcangeli, Luca Triggiani, Rosario Mazzola, Michela Buglione di Monale E Bastia, Sergio Fersino, Anna Baiguini, Barbara Alicja Jereczek-Fossa, Stefano Maria Magrini
Renal Cell Carcinoma (RCC) has historically been considered a radioresistant cancer, and radiotherapy was usually delivered with a palliative goal. Stereotactic ablative radiotherapy (SABR) allows the delivery of high doses on small treatment volumes in a safe and effective way, thus opening the doors to new applicationsof radiotherapy both in the treatment of the primary and oligometastasic disease. Aim of the current review is to explore the state of art of SABR in the therapeutic approach to RCC.
September 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28794640/volumetric-modulated-arc-therapy-for-treatment-of-solid-tumors-current-insights
#2
REVIEW
Gabriella Macchia, Francesco Deodato, Savino Cilla, Silvia Cammelli, Alessandra Guido, Martina Ferioli, Giambattista Siepe, Vincenzo Valentini, Alessio Giuseppe Morganti, Gabriella Ferrandina
AIM: This article discusses the current use of volumetric modulated arc therapy (VMAT) techniques in clinical practice and reviews the available data from clinical outcome studies in different clinical settings. An overview of available literature about clinical outcomes with VMAT stereotactic/radiosurgical treatment is also reported. MATERIALS AND METHODS: All published manuscripts reporting the use of VMAT in a clinical setting from 2009 to November 2016 were identified...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28744603/patterns-of-metastatic-progression-after-definitive-radiation-therapy-for-early-stage-and-locally-advanced-non-small-cell-lung-cancer
#3
Garrett L Jensen, Chad Tang, Kenneth R Hess, Zhongxing Liao, Daniel R Gomez
Current preclinical models of metastatic disease (particularly oligometastases) suggest that metastases appear in a hierarchical order. We attempted to identify systematic patterns of metastasis in non-small cell lung cancer (NSCLC) after radiation therapy (XRT). We analyzed 1074 patients treated from 12/21/1998 through 8/20/2012 with ≥60 Gy definitive radiation for initially non-metastatic NSCLC. Location and time of metastases were recorded. Regional nodal failure was noted, as was subsequent distal failure...
July 25, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28740933/18f-fdg-pet-response-and-clinical-outcomes-after-stereotactic-body-radiation-therapy-for-metastatic-melanoma
#4
Ryan S Youland, Ann T Packard, Miran J Blanchard, Andrea L Arnett, Gregory A Wiseman, Lisa A Kottschade, Roxana S Dronca, Svetomir N Markovic, Kenneth R Olivier, Sean S Park
BACKGROUND: Clinical data that support stereotactic body radiation therapy (SBRT) metastatic malignant melanoma (MM) are limited. Furthermore, functional imaging with 18F-fludeoxyglucose positron emission tomography (PET) may offer a more accurate post-SBRT assessment. Therefore, we assessed the clinical outcomes and metabolic response of metastatic MM after SBRT. METHODS AND MATERIALS: Patients with MM who were treated with SBRT and had pre- and post-PET scans (>1) were included in this study...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28712276/optimal-dose-and-volume-for-postoperative-radiotherapy-in-brain-oligometastases-from-lung-cancer-a-retrospective-study
#5
Seung Yeun Chung, Jong Hee Chang, Hye Ryun Kim, Byoung Chul Cho, Chang Geol Lee, Chang-Ok Suh
PURPOSE: To evaluate intracranial control after surgical resection according to the adjuvant treatment received in order to assess the optimal radiotherapy (RT) dose and volume. MATERIALS AND METHODS: Between 2003 and 2015, a total of 53 patients with brain oligometastases from non-small cell lung cancer (NSCLC) underwent metastasectomy. The patients were divided into three groups according to the adjuvant treatment received: whole brain radiotherapy (WBRT) ± boost (WBRT ± boost group, n = 26), local RT/Gamma Knife surgery (local RT group, n = 14), and the observation group (n = 13)...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28711413/-hypofractionated-stereotactic-radiotherapy-for-brain-metastasis-benefit-of-additional-whole-brain-radiotherapy
#6
P Royer, J Salleron, G Vogin, L Taillandier, C Clément-Duchêne, O Klein, J-C Faivre, D Peiffert, V Bernier
PURPOSE: To study overall survival, risk of neurological death, local recurrence and development of new brain metastasis in patients treated for brain oligometastases with hypofractionated stereotactic radiotherapy with CyberKnife(®), according to the association or not with an additional whole brain irradiation. PATIENTS AND METHODS: Institutional retrospective study of 102 patients treated for one to three brain metastasis: 76 with exclusive hypofractionated stereotactic radiotherapy and 26 with hypofractionated stereotactic radiotherapy and whole brain irradiation...
July 12, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28686211/immunological-and-inflammatory-impact-of-non-intubated-lung-metastasectomy
#7
Tommaso Claudio Mineo, Francesco Sellitri, Gianluca Vanni, Filippo Tommaso Gallina, Vincenzo Ambrogi
BACKGROUND: We hypothesized that video-assisted thoracic surgery (VATS) lung metastasectomy under non-intubated anesthesia may have a lesser immunological and inflammatory impact than the same procedure under general anesthesia. METHODS: Between December 2005 and October 2015, 55 patients with pulmonary oligometastases (at the first episode) successfully underwent VATS metastasectomy under non-intubated anesthesia. Lymphocytes subpopulation and interleukins 6 and 10 were measured at different intervals and matched with a control group composed of 13 patients with similar clinical features who refused non-intubated surgery...
July 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28684242/-hypofractionated-stereotactic-body-radiation-therapy-for-adrenal-metastases
#8
G Dupic, J Biau, A Bellière-Calandry, M Lapeyre
Adrenal glands are a common site for metastatic spread since they represent the fourth metastatic site of solid tumors. Interest in local ablative treatments of oligometastases is growing since literature suggests better progression-free survival, quality of life and potentially overall survival in selected patients. Surgery remains the first treatment of adrenal oligometastases because results are good, with a long enough follow-up. However, stereotactic radiotherapy appears to be comparable to surgery and could be proposed to elderly, unfit, inoperable patients, or even to patients whose systemic treatment should not be suspended for too long...
August 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28631741/bladder-cancer-oligometastases-and-imaging
#9
Laura S Mertens, Simon Horenblas
No abstract text is available yet for this article.
June 20, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28631740/radiotherapy-for-renal-cell-carcinoma-renaissance-of-an-overlooked-approach
#10
REVIEW
Shankar Siva, Gargi Kothari, Alexander Muacevic, Alexander V Louie, Ben J Slotman, Bin S Teh, Simon S Lo
Conventional radiotherapy previously had a limited role in the definitive treatment of renal cell carcinoma (RCC), owing to the disappointing outcomes of several trials and the perceived radioresistance of this type of cancer. In this context, radiotherapy has been relegated largely to the palliation of symptoms in patients with metastatic disease, with variable rates of response. Following the availability of newer technologies that enable safe delivery of high-dose radiotherapy, stereotactic ablative radiotherapy (SABR) has become increasingly used in patients with RCC...
June 20, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28631284/the-role-of-radiotherapy-in-bone-metastases-a-critical-review-of-current-literature
#11
REVIEW
A Kougioumtzopoulou, A Zygogianni, Z Liakouli, E Kypraiou, V Kouloulias
Radiotherapy is considered the treatment of choice for painful bone metastases. However, novel modalities of radiotherapy have emerged in the concept of oligometastasic disease. In addition, the increase of overall survival of patients with bone metastatic disease in the last decades due to systemic treatments has issued the silent topic of re-irradiation. The aim of this manuscript was to present a current thorough search of relevant literature. Originally, 6,087 articles revealed from PubMed database related to radiotherapy and bone metastases...
June 20, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28612021/oligometastases-of-gastrointestinal-cancer-origin
#12
Ernst Klar, Markus W Büchler, Hauke Lang, Florian Lordick, Jens Mittler, Takashi Mizuno, Guido Torzilli, Alexis Ulrich, Jean-Nicolas Vauthey
No abstract text is available yet for this article.
March 2017: Visceral Medicine
https://www.readbyqxmd.com/read/28612018/treatment-options-in-oligometastatic-disease-stereotactic-body-radiation-therapy-focus-on-colorectal-cancer
#13
REVIEW
Aaron T Wild, Yoshiya Yamada
BACKGROUND: Improvements in systemic therapy for metastatic colorectal cancer (CRC) have markedly extended survival, rendering local control of metastases to critical organs of increasing importance, especially in the oligometastatic setting where the disease may not yet have acquired the ability to widely disseminate. While surgical resection remains the gold standard for oligometastases in many organs, stereotactic body radiation therapy (SBRT) presents a non-invasive alternative for achieving local control...
March 2017: Visceral Medicine
https://www.readbyqxmd.com/read/28612016/oligometastatic-disease-in-the-peritoneal-space-with-gastrointestinal-cancer
#14
REVIEW
Beate Rau, Andreas Brandl, Andreas Pascher, Wieland Raue, Paul Sugarbaker
OBJECTIVES: Treatment options for patients with gastrointestinal cancer and oligometastastic disease remain the domain of the medical oncologist. However, in selected cases, attempts to remove or destroy the tumor burden seem appropriate. BACKGROUND DATA: During the last decade, the treatment of localized and isolated tumor nodules, such as lung, liver or peritoneal metastasis, has changed. Previously, these patients with metastatic disease only received palliative chemotherapy...
March 2017: Visceral Medicine
https://www.readbyqxmd.com/read/28612014/oligometastatic-disease-in-upper-gastrointestinal-cancer-how-to-proceed
#15
REVIEW
Costanza Chiapponi, Felix Berlth, Patrick S Plum, Christopher Betzler, Dirk L Stippel, Felix Popp, Christiane J Bruns
BACKGROUND: In the present study we review and discuss the current evidence and suggest how to proceed in the management of oligometastatic disease in upper gastrointestinal cancer. METHODS: An electronic search of the PubMed database for relevant articles was performed. RESULTS: Both the search for 'oligometastasis', 'oligometastases', 'oligometastatic', 'oligometastatic disease' as well as 'esophageal' and 'esophageal cancer' and the search for 'oligometastasis', 'oligometastases', 'oligometastatic', 'oligometastatic disease' as well as 'gastric', 'gastric cancer', 'stomach', and 'stomach cancer' yielded very few studies...
March 2017: Visceral Medicine
https://www.readbyqxmd.com/read/28612012/oligometastases-of-gastrointestinal-cancer-origin
#16
EDITORIAL
Nancy E Kemeny, Beate Rau
No abstract text is available yet for this article.
March 2017: Visceral Medicine
https://www.readbyqxmd.com/read/28581404/treatment-related-toxicity-in-patients-with-early-stage-non-small-cell-lung-cancer-and-coexisting-interstitial-lung-disease-a-systematic-review
#17
REVIEW
Hanbo Chen, Suresh Senan, Esther J Nossent, R Gabriel Boldt, Andrew Warner, David A Palma, Alexander V Louie
PURPOSE: Definitive treatment for patients with early-stage non-small cell lung cancer (ES-NSCLC) is usually well tolerated. Patients with ES-NSCLC and coexisting interstitial lung disease (ILD) are at increased risk of severe treatment-related toxicity after definitive therapy. The main objective of this systematic review is to provide a pooled estimation of treatment-related mortality and ILD-specific toxicity in this population of patients and to identify trends for further study. METHODS AND MATERIALS: The MEDLINE and Embase databases were queried from respective dates of inception to January 2016...
July 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28581205/testing-radical-prostatectomy-in-men-with-prostate-cancer-and-oligometastases-to-the-bone-a-randomized-controlled-feasibility-trial
#18
Prasanna Sooriakumaran
This is the Protocol of the ethically-approved TRoMbone study.
June 5, 2017: BJU International
https://www.readbyqxmd.com/read/28576747/brief-report-long-term-outcome-of-surgery-or-stereotactic-radiotherapy-for-lung-oligometastases
#19
Joyce E Lodeweges, Theo J Klinkenberg, Jan F Ubbels, Harry J M Groen, Johannes A Langendijk, Joachim Widder
Local treatment for pulmonary oligometastases (one to five lesions) employing metastasectomy or stereotactic ablative radiotherapy (SABR) was investigated in a cohort having received multidisciplinary tumour-board-based treatment decisions. First choice of treatment was surgery, SABR was recommended in case of clinical adverse factors. Propensity-score adjusted and unadjusted overall survival (OS) was the primary endpoint, local control and time-to-failure of a local-only treatment strategy were also analysed...
May 30, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28552517/cost-effectiveness-analysis-of-stereotactic-radiosurgery-alone-versus-stereotactic-radiosurgery-with-upfront-whole-brain-radiation-therapy-for-brain-metastases
#20
H Kim, M S Rajagopalan, S Beriwal, K J Smith
AIMS: Stereotactic radiosurgery (SRS) alone or upfront whole brain radiation therapy (WBRT) plus SRS are the most commonly used treatment options for one to three brain oligometastases. The most recent randomised clinical trial result comparing SRS alone with upfront WBRT plus SRS (NCCTG N0574) has favoured SRS alone for neurocognitive function, whereas treatment options remain controversial in terms of cognitive decline and local control. The aim of this study was to conduct a cost-effectiveness analysis of these two competing treatments...
May 25, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
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