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https://www.readbyqxmd.com/read/27742541/simulated-online-adaptive-magnetic-resonance-guided-stereotactic-body-radiation-therapy-for-the-treatment-of-oligometastatic-disease-of-the-abdomen-and-central-thorax-characterization-of-potential-advantages
#1
Lauren Henke, Rojano Kashani, Deshan Yang, Tianyu Zhao, Olga Green, Lindsey Olsen, Vivian Rodriguez, H Omar Wooten, H Harold Li, Yanle Hu, Jeffrey Bradley, Clifford Robinson, Parag Parikh, Jeff Michalski, Sasa Mutic, Jeffrey R Olsen
PURPOSE: To characterize potential advantages of online-adaptive magnetic resonance (MR)-guided stereotactic body radiation therapy (SBRT) to treat oligometastatic disease of the non-liver abdomen and central thorax. METHODS AND MATERIALS: Ten patients treated with RT for unresectable primary or oligometastatic disease of the non-liver abdomen (n=5) or central thorax (n=5) underwent imaging throughout treatment on a clinical MR image guided RT system. The SBRT plans were created on the basis of tumor/organ at risk (OAR) anatomy at initial computed tomography simulation (PI), and simulated adaptive plans were created on the basis of observed MR image set tumor/OAR "anatomy of the day" (PA)...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27729942/vero%C3%A2-radiotherapy-for-low-burden-cancer-789-patients-with-957-lesions
#2
R Orecchia, A Surgo, M Muto, A Ferrari, G Piperno, M A Gerardi, S Comi, C Garibaldi, D Ciardo, A Bazani, F Golino, F Pansini, C Fodor, P Romanelli, D Maestri, V Scroffi, S Mazza, B A Jereczek-Fossa
PURPOSE: The aim of this retrospective study is to evaluate patient profile, feasibility, and acute toxicity of RadioTherapy (RT) delivered by VERO® in the first 20 months of clinical activity. METHODS: Inclusion criteria: 1) adult patients; 2) limited volume cancer (M0 or oligometastatic); 3) small extracranial lesions; 4) treatment between April 2012 and December 2013 and 5) written informed consent. Two techniques were employed: intensity modulated radiotherapy (IMRT) and stereotactic body radiotherapy (SBRT)...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/26316914/stereotactic-body-radiotherapy-for-the-treatment-of-medically-inoperable-primary-renal-cell-carcinoma-current-evidence-and-future-directions
#3
REVIEW
Anand Swaminath, William Chu
The incidence of renal cell carcinoma (RCC) is steadily rising due to an aging population and more frequent imaging of the abdomen for other medical conditions. While surgery remains the standard of care treatment for localized disease, many patients are unfit due to their advanced age and medical comorbidities. In these patients, an active surveillance strategy or ablative therapies, including radiofrequency/microwave ablation or cryotherapy, can be offered. Such options have limitations particularly with fast growing, or larger tumors...
July 2015: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/26183933/the-role-of-stereotactic-body-radiation-therapy-sbrt-in-the-treatment-of-oligometastatic-disease-in-the-elderly
#4
Marta Scorsetti, Elena Clerici, Piera Navarria, Giuseppe D'Agostino, Lorenzo Piergallini, Fiorenza De Rose, Annamaria Ascolese, Angelo Tozzi, Cristina Iftode, Elisa Villa, Tiziana Comito, Ciro Franzese, Pietro Mancosu, Stefano Tomatis, Luca Cozzi
OBJECTIVE: To report about clinical outcome of stereotactic body radiation therapy (SBRT) in the treatment of oligometastatic disease in elderly patients. METHODS: Patients with 1-4 inoperable metastases were treated with SBRT. Dose prescription ranged from 40 to 75 Gy in 3-8 fractions. SBRT was delivered using the volumetric modulated arc therapy technique with flattening filter-free photon beams. The primary end points were in-field local control (LC) and toxicity...
September 2015: British Journal of Radiology
https://www.readbyqxmd.com/read/25838188/differences-between-colon-cancer-primaries-and-metastases-using-a-molecular-assay-for-tumor-radiation-sensitivity-suggest-implications-for-potential-oligometastatic-sbrt-patient-selection
#5
Kamran A Ahmed, William J Fulp, Anders E Berglund, Sarah E Hoffe, Thomas J Dilling, Steven A Eschrich, Ravi Shridhar, Javier F Torres-Roca
PURPOSE: We previously developed a multigene expression model of tumor radiation sensitivity index (RSI) with clinical validation in multiple independent cohorts (breast, rectal, esophageal, and head and neck patients). The purpose of this study was to assess differences between RSI scores in primary colon cancer and metastases. METHODS AND MATERIALS: Patients were identified from our institutional review board-approved prospective observational protocol. A total of 704 metastatic and 1362 primary lesions were obtained from a de-identified metadata pool...
July 15, 2015: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/25207396/comparing-measurement-derived-3dvh-and-machine-log-file-derived-dose-reconstruction-methods-for-vmat-qa-in-patient-geometries
#6
COMPARATIVE STUDY
Neelam Tyagi, Kai Yang, Di Yan
The purpose of this study was to compare the measurement-derived (3DVH) dose reconstruction method with machine log file-derived dose reconstruction method in patient geometries for VMAT delivery. A total of ten patient plans were selected from a regular fractionation plan to complex SBRT plans. Treatment sites in the lung and abdomen were chosen to explore the effects of tissue heterogeneity on the respective dose reconstruction algorithms. Single- and multiple-arc VMAT plans were generated to achieve the desired target objectives...
2014: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/25184052/influence-of-segment-width-on-plan-quality-for-volumetric-modulated-arc-based-stereotactic-body-radiotherapy
#7
REVIEW
Karthikeyan Nithiyanantham, Ganesh Kadirampatti Mani, Vikraman Subramani, Karrthick Karukkupalayam Palaniappan, Mohanraj Uthiran, Sennniandavar Vellengiri, Sambasivaselli Raju, Sanjay S Supe, Tejinder Kataria
AIM: To study the influence of segment width on plan quality for volumetric modulated arc based stereotactic body radiotherapy. BACKGROUND: The redundancy of modulation for regularly shaped small volume tumors results in creation of many small segments and an increase of monitor units, with a consequent prolongation of treatment and uncertainty in treatment delivery. MATERIALS AND METHODS: Six cases each in lung, abdomen and liver were taken for the study...
September 2014: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/24801474/the-impact-of-abdominal-compression-on-outcome-in-patients-treated-with-stereotactic-body-radiotherapy-for-primary-lung-cancer
#8
Wambaka Ange Mampuya, Yukinori Matsuo, Nami Ueki, Mitsuhiro Nakamura, Nobutaka Mukumoto, Akira Nakamura, Yusuke Iizuka, Takahiro Kishi, Takashi Mizowaki, Masahiro Hiraoka
The aim of this study was to evaluate the impact of abdominal compression (AC) on outcome in patients treated with stereotactic body radiotherapy (SBRT) for primary lung cancer. We retrospectively reviewed data for 47 patients with histologically proven non-small cell lung cancer and lung tumour motion ≥ 8 mm treated with SBRT. Setup error was corrected based on bony structure. The differences in overall survival (OS), local control (LC) and disease-free survival (DFS) were evaluated to compare patients treated with AC (n = 22) and without AC (n = 25)...
September 2014: Journal of Radiation Research
https://www.readbyqxmd.com/read/24401365/adequacy-of-inhale-exhale-breathhold-ct-based-itv-margins-and-image-guided-registration-for-free-breathing-pancreas-and-liver-sbrt
#9
Wensha Yang, Benedick A Fraass, Robert Reznik, Nicholas Nissen, Simon Lo, Laith H Jamil, Kapil Gupta, Howard Sandler, Richard Tuli
PURPOSE: To evaluate use of breath-hold CTs and implanted fiducials for definition of the internal target volume (ITV) margin for upper abdominal stereotactic body radiation therapy (SBRT). To study the statistics of inter- and intra-fractional motion information. METHODS AND MATERIALS: 11 patients treated with SBRT for locally advanced pancreatic cancer (LAPC) or liver cancer were included in the study. Patients underwent fiducial implantation, free-breathing CT and breath-hold CTs at end inhalation/exhalation...
January 9, 2014: Radiation Oncology
https://www.readbyqxmd.com/read/24007151/interfraction-variation-in-lung-tumor-position-with-abdominal-compression-during-stereotactic-body-radiotherapy
#10
Wambaka Ange Mampuya, Mitsuhiro Nakamura, Yukinori Matsuo, Nami Ueki, Yusuke Iizuka, Takahiro Fujimoto, Shinsuke Yano, Hajime Monzen, Takashi Mizowaki, Masahiro Hiraoka
PURPOSE: To assess the effect of abdominal compression on the interfraction variation in tumor position in lung stereotactic body radiotherapy (SBRT) using cone-beam computed tomography (CBCT) in a larger series of patients with large tumor motion amplitude. METHODS: Thirty patients with lung tumor motion exceeding 8 mm who underwent SBRT were included in this study. After translational and rotational initial setup error was corrected based on bone anatomy, CBCT images were acquired for each fraction...
September 2013: Medical Physics
https://www.readbyqxmd.com/read/23395063/clinical-application-of-flattening-filter-free-beams-for-extracranial-stereotactic-radiotherapy
#11
Stephanie Lang, Binaya Shrestha, Shaun Graydon, Frederique Cavelaars, Claudia Linsenmeier, Jan Hrbacek, Stephan Klöck, Gabriela Studer, Oliver Riesterer
PURPOSE: To investigate the clinical application of flattening filter free (FFF) beams at maximum dose rate for stereotactic body radiotherapy (SBRT). METHODS AND MATERIALS: Patients with tumors in the lung or abdomen were subjected to SBRT using 6 MV FFF or 10 MV FFF beams. For each patient, three plans were calculated using 6 MV flattened, 6 MV FFF, and 10 MV FFF beams. Treatment times were recorded and analyzed, and tumor displacements were assessed by pre- and post-treatment cone beam computed tomography (CBCT)...
February 2013: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/23216821/volumetric-modulated-arc-therapy-with-flattening-filter-free-beams-for-isolated-abdominal-pelvic-lymph-nodes-report-of-dosimetric-and-early-clinical-results-in-oligometastatic-patients
#12
Filippo Alongi, Antonella Fogliata, Elena Clerici, Pierina Navarria, Angelo Tozzi, Tiziana Comito, Anna Maria Ascolese, Alessandro Clivio, Francesca Lobefalo, Giacomo Reggiori, Luca Cozzi, Pietro Mancosu, Stefano Tomatis, Marta Scorsetti
BACKGROUND: SBRT is a safe and efficient strategy to locally control multiple metastatic sites. While research in the physics domain for Flattening Filter Free Beams (FFF) beams is increasing, there are few clinical data of FFF beams in clinical practice. Here we reported dosimentric and early clinical data of SBRT and FFF delivery in isolated lymph node oligometastatic patients. METHODS: Between October 2010 and March 2012, 34 patients were treated with SBRT for oligometastatic lymph node metastasis on a Varian TrueBeam(TM) treatment machine using Volumetric Modulated Arc Therapy (RapidArc)...
2012: Radiation Oncology
https://www.readbyqxmd.com/read/22568625/re-irradiation-outcome-cumulative-dose-and-toxicity-in-patients-retreated-with-stereotactic-radiotherapy-in-the-abdominal-or-pelvic-region
#13
Huda Abusaris, M Hoogeman, Joost J Nuyttens
UNLABELLED: The purpose of the present study was to explore the outcome, cumulative dose in tumor and organs at risk and toxicity after extra-cranial stereotactic re-irradiation. Twenty-seven patients were evaluated who had been re-irradiated with stereotactic body radiotherapy (SBRT) after conventional radiotherapy (CRT). The dose summation of the SBRT and CRT plans was done by dose point calculations accounting for fraction size by the linear-quadratic model. Efficacy and toxicity was scored by looking at the reduction in tumor size, pain and bleeding...
December 2012: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/22020702/stereotactic-body-radiotherapy-for-multisite-extracranial-oligometastases-final-report-of-a-dose-escalation-trial-in-patients-with-1-to-5-sites-of-metastatic-disease
#14
Joseph K Salama, Michael D Hasselle, Steven J Chmura, Renuka Malik, Neil Mehta, Kamil M Yenice, Victoria M Villaflor, Walter M Stadler, Philip C Hoffman, Ezra E W Cohen, Philip P Connell, Daniel J Haraf, Everett E Vokes, Samuel Hellman, Ralph R Weichselbaum
BACKGROUND: A subset of patients with metastatic cancer in limited organs may benefit from metastasis-directed therapy. The authors investigated whether patients with limited metastases could be safely treated with metastasis-directed radiotherapy. METHODS: Patients with 1 to 5 metastatic cancer sites with a life expectancy of >3 months received escalating stereotactic body radiotherapy (SBRT) doses to all known cancer sites. Patients were followed radiographically with CT scans of the chest, abdomen, and pelvis and metabolically with fluorodeoxyglucose-positron emission tomography, 1 month after treatment, and then every 3 months...
June 1, 2012: Cancer
https://www.readbyqxmd.com/read/21910868/feasibility-and-early-clinical-assessment-of-flattening-filter-free-fff-based-stereotactic-body-radiotherapy-sbrt-treatments
#15
Marta Scorsetti, Filippo Alongi, Simona Castiglioni, Alessandro Clivio, Antonella Fogliata, Francesca Lobefalo, Pietro Mancosu, Pierina Navarria, Valentina Palumbo, Chiara Pellegrini, Sara Pentimalli, Giacomo Reggiori, Anna M Ascolese, Antonella Roggio, Stefano Arcangeli, Angelo Tozzi, Eugenio Vanetti, Luca Cozzi
PURPOSE: To test feasibility and safety of clinical usage of Flattening Filter Free (FFF) beams for delivering ablative stereotactic body radiation therapy (SBRT) doses to various tumor sites, by means of Varian TrueBeam™ (Varian Medical Systems). METHODS AND MATERIALS: Seventy patients were treated with SBRT and FFF: 51 lesions were in the thorax (48 patients),10 in the liver, 9 in isolated abdominal lymph node, adrenal gland or pancreas. Doses ranged from 32 to 75 Gy, depending on the anatomical site and the volume of the lesion to irradiate...
2011: Radiation Oncology
https://www.readbyqxmd.com/read/21338272/stereotactic-body-radiation-therapy-for-abdominal-targets-using-volumetric-intensity-modulated-arc-therapy-with-rapidarc-feasibility-and-clinical-preliminary-results
#16
Marta Scorsetti, Mario Bignardi, Filippo Alongi, Antonella Fogliata, Pietro Mancosu, Piera Navarria, Simona Castiglioni, Sara Pentimalli, Angelo Tozzi, Luca Cozzi
PURPOSE: To report early clinical experience in stereotactic body radiation therapy (SBRT) delivered using volumetric intensity modulated arc therapy with RapidArc (RA) in patients with primary or metastatic tumours at abdominal sites. MATERIAL AND METHODS: Thirty-seven consecutive patients were treated using RA. Of these, 16 had primary or metastatic liver tumours, nine had pancreatic cancer and 12 a nodal metastasis in the retro-peritoneum. Dose prescription varied from 45 to 75 Gy to the Clinical Target Volume in 3 to 6 fractions...
May 2011: Acta Oncologica
https://www.readbyqxmd.com/read/21075559/effect-of-immobilization-and-performance-status-on-intrafraction-motion-for-stereotactic-lung-radiotherapy-analysis-of-133-patients
#17
Winnie Li, Thomas G Purdie, Mojgan Taremi, Sharon Fung, Anthony Brade, B C John Cho, Andrew Hope, Alexander Sun, David A Jaffray, Andrea Bezjak, Jean-Pierre Bissonnette
PURPOSE: To assess intrafractional geometric accuracy of lung stereotactic body radiation therapy (SBRT) patients treated with volumetric image guidance. METHODS AND MATERIALS: Treatment setup accuracy was analyzed in 133 SBRT patients treated via research ethics board-approved protocols. For each fraction, a localization cone-beam computed tomography (CBCT) scan was acquired for soft-tissue registration to the internal target volume, followed by a couch adjustment for positional discrepancies greater than 3 mm, verified with a second CBCT scan...
December 1, 2011: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/20947263/interfraction-liver-shape-variability-and-impact-on-gtv-position-during-liver-stereotactic-radiotherapy-using-abdominal-compression
#18
Cynthia L Eccles, Laura A Dawson, Joanne L Moseley, Kristy K Brock
PURPOSE: For patients receiving liver stereotactic body radiotherapy (SBRT), abdominal compression can reduce organ motion, and daily image guidance can reduce setup error. The reproducibility of liver shape under compression may impact treatment delivery accuracy. The purpose of this study was to measure the interfractional variability in liver shape under compression, after best-fit rigid liver-to-liver registration from kilovoltage (kV) cone beam computed tomography (CBCT) scans to planning computed tomography (CT) scans and its impact on gross tumor volume (GTV) position...
July 1, 2011: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/20800375/clinical-outcome-of-hypofractionated-stereotactic-radiotherapy-for-abdominal-lymph-node-metastases
#19
Mario Bignardi, Piera Navarria, Pietro Mancosu, Luca Cozzi, Antonella Fogliata, Angelo Tozzi, Simona Castiglioni, Carlo Carnaghi, Maria Chiara Tronconi, Armando Santoro, Marta Scorsetti
PURPOSE: We report the medium-term clinical outcome of hypofractionated stereotactic body radiotherapy (SBRT) in a series of patients with either a solitary metastasis or oligometastases from different tumors to abdominal lymph nodes. METHODS AND MATERIALS: Between January 2006 and June 2009, 19 patients with unresectable nodal metastases in the abdominal retroperitoneal region were treated with SBRT. Of the patients, 11 had a solitary nodal metastasis and 8 had a dominant nodal lesion as part of oligometastatic disease, defined as up to five metastases...
November 1, 2011: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/20674466/quantifying-variability-in-radiation-dose-due-to-respiratory-induced-tumor-motion
#20
S E Geneser, J D Hinkle, R M Kirby, B Wang, B Salter, S Joshi
State of the art radiation treatment methods such as hypo-fractionated stereotactic body radiation therapy (SBRT) can successfully destroy tumor cells and avoid damaging healthy tissue by delivering high-level radiation dose that precisely conforms to the tumor shape. Though these methods work well for stationary tumors, SBRT dose delivery is particularly susceptible to organ motion, and few techniques capable of resolving and compensating for respiratory-induced organ motion have reached clinical practice...
August 2011: Medical Image Analysis
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