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https://www.readbyqxmd.com/read/29332497/dosimetric-analysis-of-microscopic-disease-in-sbrt-for-lung-cancers
#1
Ronghu Mao, Lingling Tian, You Zhang, Lei Ren, Renqi Gao, Fang-Fang Yin, Hong Ge
OBJECTIVE: The objective of this study is to theoretically and experimentally evaluate the dosimetry in the microscopic disease regions surrounding the tumor under stereotactic body radiation therapy of lung cancer. METHODS: For simplicity, the tumor was considered moving along 1 dimension with a periodic function. The probability distribution function of the tumor position was generated according to the motion pattern and was used to estimate the delivered dose in the microscopic disease region...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29331227/the-impact-of-technology-on-the-changing-practice-of-lung-sbrt
#2
REVIEW
Marianne Camille Aznar, Samantha Warren, Mischa Hoogeman, Mirjana Josipovic
Stereotactic body radiotherapy (SBRT) for lung tumours has been gaining wide acceptance in lung cancer. Here, we review the technological evolution of SBRT delivery in lung cancer, from the first treatments using the stereotactic body frame in the 1990's to modern developments in image guidance and motion management. Finally, we discuss the impact of current technological approaches on the requirements for quality assurance as well as future technological developments.
January 10, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29327241/a-suvmax-based-propensity-matched-analysis-of-stereotactic-body-radiotherapy-versus-surgery-in-stage-i-non-small-cell-lung-cancer-unveiling-the-role-of-18f-fdg-pet-ct-in-clinical-decision-making
#3
L Ye, F Xu, S Shi, Z Zeng, X Jin, Y Huang, C Lu, J Gu, D Ge, J He
BACKGROUND: The value of maximum standard uptake value (SUVmax) was overlooked in current studies comparing stereotactic body radiotherapy (SBRT) versus surgery for stage I non-small cell lung cancer (NSCLC). Herein, we aimed to compare the 3-year outcomes based on patients for whom SUVmax were available, and to explore the role of SUVmax in clinical decision-making. METHODS: From January 2010 to June 2016, data of eligible patients were collected. Patient variables and clinical outcomes were compared in both unmatched and matched groups using propensity score matching (PSM)...
January 11, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29325801/editorial-the-role-of-medical-physics-in-lung-sbrt
#4
EDITORIAL
Pietro Mancosu, Andrew Nisbet, Núria Jornet
Stereotactic body radiation therapy (SBRT) has become a standard treatment for non-operable patients with early stage non-small cell lung cancer (NSCLC). In this context, medical physics community has largely helped in the starting and the growth of this technique. In fact, SBRT requires the convergence of many different features for delivering large doses in few fractions to small moving target in an heterogeneous medium. The special issue of last month, was focused on the different physics challenges in lung SBRT...
January 9, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29312866/quantitative-texture-analysis-on-pre-treatment-computed-tomography-predicts-local-recurrence-in-stage-i-non-small-cell-lung-cancer-following-stereotactic-radiation-therapy
#5
Carole Dennie, Rebecca Thornhill, Carolina A Souza, Cecilia Odonkor, Jason R Pantarotto, Robert MacRae, Graham Cook
Background: The prediction of local recurrence (LR) of stage I non-small cell lung cancer (NSCLC) after definitive stereotactic body radiotherapy (SBRT) remains elusive. The purpose of this study was to assess whether quantitative imaging features on pre-treatment computed tomography (CT) can predict LR beyond 18 (18F) fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/CT maximum standard uptake value (SUVmax). Methods: This retrospective study evaluated 36 patients with 37 stage I NSCLC who had local tumor control (LC; n=19) and (LR; n=18)...
December 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29310420/the-role-of-stereotactic-body-radiation-therapy-in-oligometastatic-colorectal-cancer-clinical-case-report-of-a-long-responder-patient-treated-with-regorafenib-beyond-progression
#6
Michela Roberto, Rosa Falcone, Federica Mazzuca, Livia Archibugi, Nadia Castaldi, Andrea Botticelli, Mattia Falchetto Osti, Paolo Marchetti
RATIONALE: Regorafenib is the new standard third-line therapy in metastatic colorectal cancer (mCRC). However, the reported 1-year overall survival rate does not exceed 25%. PATIENT CONCERNS: A 55-year-old man affected by mCRC, treated with regorafenib combined with stereotactic body radiotherapy (SBRT), showing a durable response. INTERVENTIONS: After 6 months of regorafenib, a PET/CT scan revealed a focal uptake in a solid lung nodule which was treated with SBRT, whereas continuing regorafenib administration...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29299403/radiological-differential-diagnosis-between-fibrosis-and-recurrence-after-stereotactic-body-radiation-therapy-sbrt-in-early-stage-non-small-cell-lung-cancer-nsclc
#7
Rezarta Frakulli, Fabrizio Salvi, Damiano Balestrini, Marcella Palombarini, Ilir Akshija, Silvia Cammelli, Alessio Giuseppe Morganti, Maurizio Zompatori, Giovanni Frezza
Background: Parenchymal changes after stereotactic body radiation therapy (SBRT) make differential diagnosis between treatment outcomes and disease recurrence often difficult. The purpose of our study was to identify the radiographic features detectable at computed tomography (CT) scan [high-risk features (HRFs)] that allow enough specificity and sensitivity for early detection of recurrence. Methods: We retrospectively evaluated patients who underwent SBRT for inoperable early stage non-small cell lung cancer (NSCLC)...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29290784/systemic-inflammation-biomarkers-predict-survival-in-patients-of-early-stage-non-small-cell-lung-cancer-treated-with-stereotactic-ablative-radiotherapy-a-single-center-experience
#8
Hui Luo, Hong Ge, Yingying Cui, Jiangong Zhang, Ruitai Fan, Anping Zheng, Xiaoli Zheng, Yanan Sun
Background: Increasing evidence indicates a relationship between systemic inflammation and survival following treatment in various tumors. However, the correlation of systematic inflammation with survival after stereotactic ablative radiotherapy (SABR) in early stage non-small cell lung cancer (NSCLC) has not been well established. Patients and methods: We retrospectively analyzed patients with newly diagnosed early stage NSCLC treated with SABR in a single institution from 2011 to 2015. The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte- monocyte ratio (LMR) were calculated as systemic inflammation biomarkers...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29290248/stereotactic-body-radiation-therapy-for-isolated-hilar-and-mediastinal-non-small-cell-lung-cancers
#9
Zachary D Horne, Adam H Richman, Michael J Dohopolski, David A Clump, Steven A Burton, Dwight E Heron
OBJECTIVES: The seminal phase II trial for pulmonary stereotactic body radiation therapy (SBRT) suggested that SBRT to central lesions resulted in unacceptable toxicity. Alternative dose-fractionation schemes have been proposed which may improve safety without compromise of efficacy. We report our institutional outcomes of SBRT for hilar/mediastinal non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: A retrospective review was conducted of patients with NSCLC in a hilar or mediastinal nodal station which was treated with SBRT...
January 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29280445/the-influence-of-health-insurance-policy-on-radiation-oncology-physician-sbrt-sabr-use-practices-a-north-american-survey
#10
Jenny Guo, Hyun Kim, Ingrid Kalchman, Tu D Dan, Tingting Zhan, Maria Werner-Wasik
PURPOSE: European data suggest that 8-fraction stereotactic body radiation therapy (SBRT) regimens may be similar in efficacy with less toxicity than ≤5-fraction SBRT for central lung lesions. However, under current Centers for Medicare and Medicaid Services guidelines, SBRT in the United States (US) is reimbursed for only ≤5 fractions, whereas there are no such restrictions for reimbursement in Canada. We hypothesize that US-specific SBRT reimbursement policies influence the use of ≥5-fraction SBRT in US academic centers in comparison with comparable Canadian centers...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29277565/pilot-study-of-the-safety-and-efficacy-of-dose-escalation-in-stereotactic-body-radiotherapy-for-peripheral-lung-tumors
#11
Takamasa Mitsuyoshi, Yukinori Matsuo, Takashi Shintani, Yusuke Iizuka, Nami Ueki, Mitsuhiro Nakamura, Takashi Mizowaki
BACKGROUND: This pilot study aimed to evaluate the safety and efficacy of a dose escalation method for the treatment of peripheral lung tumors by administrating steep dose gradients in the target volumes via stereotactic body radiotherapy (SBRT). PATIENTS AND METHODS: Patients with peripheral lung tumors were enrolled onto this study and treated with SBRT using a total dose of 70 Gy in 4 fractions at target isocenter, covering the planning target volume surface with 70% of the isodose...
November 28, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29275314/radiotherapy-and-tyrosine-kinase-inhibitors-in-stage-iv-non-small-cell-lung-cancer-real-life-experience
#12
Paolo Borghetti, Marco Lorenzo Bonù, Elisa Roca, Sara Pedretti, Emiliano Salah, Anna Baiguini, Diana Greco, Luca Triggiani, Marta Maddalo, Niccolò Giaj Levra, Filippo Alongi, Stefano Maria Magrini, Michela Buglione
AIM: To investigate the role of conventional radiotherapy (RT) and stereotactic body radiotherapy (SBRT) in patients with epidermal growth factor (EGFR)-mutant or anaplastic lymphoma kinase (ALK) rearrangement-positive metastatic non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: Fifty patients with EGFR-mutated or ALK rearrangement-positive NSCLC were treated at our Institution. Radiotherapy was delivered before, after or concomitantly with tyrosine kinase inhibitors (TKIs)...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29275308/early-pet-ct-after-stereotactic-radiotherapy-for-stage-1-non-small-cell-lung-carcinoma-is-predictive-of-local-control
#13
Marguerite Tyran, Nathalie Charrier, Julien Darreon, Anne Madroszyk, Agnes Tallet, Naji Salem
BACKGROUND/AIM: Radiological evaluation after stereotactic-body-radiotherapy (SBRT) for non-small-cell lung carcinoma (NSCLC) is often difficult due to lung radiation-induced image modifications on computed tomographic (CT) scan. The aim of this study was to evaluate positron-emission tomography-computed tomography (PET-CT) using fluorodeoxyglucose after SBRT in primary lung cancer. PATIENTS AND METHODS: Eighteen patients with histologically proven NSCLC were treated with SBRT...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29249566/evaluation-of-mlc-leaf-transmission-on-imrt-treatment-plan-quality-of-patients-with-advanced-lung-cancer
#14
Jiayun Chen, Guishan Fu, Minghui Li, Yixin Song, Jianrong Dai, Junjie Miao, Zhiqiang Liu, Yexiong Li
The purpose of this paper was to evaluate the impact of leaf treatment of multileaf collimator (MLC) in plan quality of intensity-modulated radiotherapy (IMRT) of patients with advanced lung cancer. Five MLCs with different leaf transmissions (0.01%, 0.5%, 1.2%, 1.8%, and 3%) were configured for an accelerator in a treatment planning system. Correspondingly, 5 treatment plans with the same optimization setting were created and evaluated quantitatively for each patient (11 patients total) who was diagnosed with advanced lung cancer...
December 14, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29233523/stereotactic-body-radiation-therapy-for-stage-i-non-small-cell-lung-cancer-the-importance-of-treatment-planning-algorithm-and-evaluation-of-a-tumor-control-probability-model
#15
Nitin Ohri, Wolfgang Tomé, Shalom Kalnicki, Madhur Garg
BACKGROUND: Stereotactic body radiation therapy (SBRT) is increasingly used to treat early-stage non-small cell lung cancer (NSCLC). A previous report introduced the term size-adjusted biologically effective dose (sBED), which accounts for tumor diameter and biologically effective dose (BED) and may be used to predict the likelihood of local control following SBRT. Here we seek to replicate those findings using a separate dataset. METHODS AND MATERIALS: We queried the RSSearch Patient Registry for patients treated with SBRT for stage I NSCLC...
October 7, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29218841/improvement-of-conformal-arc-plans-by-using-deformable-margin-delineation-method-for-stereotactic-lung-radiotherapy
#16
Görkem Güngör, Melek Demir, Gökhan Aydın, Bülent Yapıcı, Banu Atalar, Enis Özyar
PURPOSE: Stereotactic body radiotherapy (SBRT) is an established treatment technique in the management of medically inoperable early stage non-small cell lung cancer (NSCLC). Different techniques such as volumetric modulated arc (VMAT) and three-dimensional conformal arc (DCA) can be used in SBRT. Previously, it has been shown that VMAT is superior to DCA technique in terms of plan evaluation parameters. However, DCA technique has several advantages such as ease of use and considerable shortening of the treatment time...
December 7, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29209835/patient-clinician-communication-among-patients-with-stage-i-lung-cancer
#17
Shannon M Nugent, Sara E Golden, Charles R Thomas, Mark E Deffebach, Mithran S Sukumar, Paul H Schipper, Brandon H Tieu, Drew Moghanaki, Juan Wisnivesky, Christopher Slatore
PURPOSE: Limited data exist about patient-centered communication (PCC) and patient-centered outcomes among patients who undergo surgery or stereotactic body radiation therapy (SBRT) for stage I non-small cell lung cancer (NSCLC). We aimed to examine the relationship between PCC and decision-making processes among NSCLC patients, using baseline data from a prospective, multicenter study. METHODS: Patients with stage 1 NSCLC completed a survey prior to treatment initiation...
December 5, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29199709/stereotactic-body-radiation-therapy-for-early-stage-primary-lung-cancer-is-an-active-breath-coordinator-necessary-an-audit-from-a-tertiary-cancer-care-center
#18
R Madhavan, P S Renilmon, H M Nair, A Lal, S S Nair, U G Unnikrishnan, D Makuny
CONTEXT: The hypofractionated stereotactic body radiation therapy (SBRT) has emerged as a safe and effective treatment modality for early-stage nonsmall cell lung carcinoma. AIMS: An audit SBRT in primary lung cancer treated in our center with and without an active breath coordinator (ABC) was undertaken to evaluate its impact on target volumes and clinical outcomes. SETTINGS AND DESIGN: This was an observational study. MATERIALS AND METHODS: Nine patients with lung carcinoma were treated from January 2014 to August 2016...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29198624/stereotactic-body-radiation-therapy-versus-surgery-for-early-lung-cancer-among-us%C3%A2-veterans
#19
Alex K Bryant, Robert C Mundt, Ajay P Sandhu, James J Urbanic, Andrew B Sharabi, Samir Gupta, Megan E Daly, James D Murphy
BACKGROUND: Stereotactic body radiation therapy (SBRT) has been proposed as a potential alternative to surgery for early lung cancer, although we lack well-powered prospective randomized data comparing these treatments, and existing studies suffer from incomplete information on confounders that can bias results. Here, we evaluated the comparative effectiveness of surgery and SBRT in lung cancer treatment using a large extensively detailed database from the Veteran's Affairs system. METHODS: We identified veterans with biopsy-proven clinical stage I non-small cell lung cancer diagnosed between 2006 and 2015 from within the Veteran's Affairs Informatics and Computing Infrastructure...
November 21, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29187237/-it-wasn-t-as-bad-as-i-thought-it-would-be-a-qualitative-study-of-early-stage-non-small-cell-lung-cancer-patients-after-treatment
#20
Sara E Golden, Charles R Thomas, Mark E Deffebach, Mithran S Sukumar, Paul H Schipper, Brandon H Tieu, Andrew Y Kee, Andrew C Tsen, Christopher G Slatore
OBJECTIVE: While surgical resection is recommended for most patients with early stage lung cancer, stereotactic body radiotherapy (SBRT) is being increasingly utilized. Provider-patient communication regarding risks/benefits of each approach may be a modifiable factor leading to improved patient-centered outcomes. Our objective was to determine a framework and recommended strategies on how to best communicate with patients with early stage non-small cell lung cancer (NSCLC) in the post-treatment setting...
November 29, 2017: BMC Research Notes
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