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https://www.readbyqxmd.com/read/27912764/sbrt-for-centrally-localized-nsclc-what-is-too-central
#1
J Roesch, C Panje, F Sterzing, F Mantel, U Nestle, N Andratschke, M Guckenberger
PURPOSE: Current guidelines recommend stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer (NSCLC) in medically inoperable patients. There are excellent outcome and toxicity data for SBRT of peripheral lung tumors. However, the discussion on SBRT for centrally located tumors is controversial. This study evaluated current clinical practice regarding SBRT of centrally located lung tumors, to identify common fractionation schedules and commonly accepted contraindications for SBRT...
December 3, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27908621/radiotherapy-with-curative-intent-in-patients-with-early-stage-medically-inoperable-non-small-cell-lung-cancer-a-systematic-review
#2
REVIEW
Conrad B Falkson, Emily T Vella, Edward Yu, Medhat El-Mallah, Robert Mackenzie, Peter M Ellis, Yee C Ung
Patients with early-stage non-small-cell lung cancer (NSCLC) who are unable to undergo surgery can be offered radiation therapy (RT). Previously, conventional RT was offered; however, newer techniques such as stereotactic body RT (SBRT) have become available. The objective of the present systematic review was to investigate the effectiveness of RT with curative intent in patients with early-stage medically inoperable NSCLC. MEDLINE, EMBASE, and the Cochrane Library were searched for studies comparing stereotactic RT with curative intent compared with observation or other types of RT for early-stage, medically inoperable, NSCLC...
October 27, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27908620/location-matters-stage-i-non-small-cell-carcinomas-of-the-lower-lobes-treated-with-stereotactic-body-radiation-therapy-are-associated-with-poor-outcomes
#3
Narek Shaverdian, Darlene Veruttipong, Jason Wang, Patrick Kupelian, Michael Steinberg, Percy Lee
INTRODUCTION: The lung is a heterogeneous organ with relative overperfusion of the lung bases. We determined whether a lower lobe primary tumor location was associated with poor outcomes in the setting of stage I non-small-cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT). PATIENTS AND METHODS: The data from consecutive patients with stage I NSCLC treated from 2009 to 2014 with curative intent SBRT were analyzed. Primary tumors in the right and left lower lobes were compared against the tumors in all other locations to determine whether a lower lobe location was associated with worse local, regional, and distant control and worse relapse-free and overall survival...
October 28, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27876604/predictors-and-patterns-of-regional-recurrence-following-lung-sbrt-a-report-from-the-elekta-lung-research-group
#4
Meredith E Giuliani, Andrew Hope, Victor Mangona, Matthias Guckenberger, Frederick Mantel, Heike Peulen, Jan-Jakob Sonke, José Belderbos, Maria Werner-Wasik, Hong Ye, Inga S Grills
INTRODUCTION: The objective of this study was to determine the predictors and patterns of regional recurrence (RR) following stereotactic body radiotherapy (SBRT) for primary lung cancers. MATERIAL AND METHODS: Details of patient factors, treatment, and outcome factors were extracted from a multi-institutional (5) database. All events were calculated from the end of radiotherapy. Estimates of local recurrence, RR, and distant metastases (DM) were calculated using the competing risk method...
October 26, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27876603/canadian-phase-iii-randomized-trial-of-stereotactic-body-radiotherapy-versus-conventionally-hypofractionated-radiotherapy-for-stage-i-medically-inoperable-non-small-cell-lung-cancer-rationale-and-protocol-design-for-the-ontario-clinical-oncology-group-ocog
#5
Anand Swaminath, Marcin Wierzbicki, Sameer Parpia, James R Wright, Theodoros K Tsakiridis, Gordon S Okawara, Vijayananda Kundapur, Alexis Bujold, Naseer Ahmed, Khalid Hirmiz, Elizabeth Kurien, Edith Filion, Zsolt Gabos, Sergio Faria, Alexander V Louie, Timothy Owen, Elaine Wai, Kevin Ramchandar, Elisa K Chan, Jim Julian, Kathryn Cline, Timothy J Whelan
We describe a Canadian phase III randomized controlled trial of stereotactic body radiotherapy (SBRT) versus conventionally hypofractionated radiotherapy (CRT) for the treatment of stage I medically inoperable non-small-cell lung cancer (OCOG-LUSTRE Trial). Eligible patients are randomized in a 2:1 fashion to either SBRT (48 Gy in 4 fractions for peripherally located lesions; 60 Gy in 8 fractions for centrally located lesions) or CRT (60 Gy in 15 fractions). The primary outcome of the study is 3-year local control, which we hypothesize will improve from 75% with CRT to 87...
October 3, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27871671/tumor-control-probability-modeling-for-stereotactic-body-radiation-therapy-of-early-stage-lung-cancer-using-multiple-bio-physical-models
#6
REVIEW
Feng Liu, An Tai, Percy Lee, Tithi Biswas, George X Ding, Isaam El Naqa, Jimm Grimm, Andrew Jackson, Feng-Ming Spring Kong, Tamara LaCouture, Billy Loo, Moyed Miften, Timothy Solberg, X Allen Li
This work is to analyze pooled clinical data using different radiobiological models and to understand the relationship between biologically effective dose (BED) and tumor control probability (TCP) for stereotactic body radiotherapy (SBRT) of early-stage non-small cell lung cancer (NSCLC). The clinical data of 1-, 2-, 3-, and 5-year actuarial or Kaplan-Meier TCP from 46 selected studies were collected for SBRT of NSCLC in the literature. The TCP data were separated for Stage T1 and T2 tumors if possible, otherwise collected for combined stages...
November 18, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27869080/the-effect-of-biologically-effective-dose-and-radiation-treatment-schedule-on-overall-survival-in-stage-i-non-small-cell-lung-cancer-patients-treated-with-stereotactic-body-radiation-therapy
#7
John M Stahl, Rudi Ross, Eileen M Harder, Brandon R Mancini, Pamela R Soulos, Steven E Finkelstein, Timothy D Shafman, Arie P Dosoretz, Suzanne B Evans, Zain A Husain, James B Yu, Cary P Gross, Roy H Decker
PURPOSE: To determine the effect of biologically effective dose (BED10) and radiation treatment schedule on overall survival (OS) in patients with early-stage non-small cell lung cancer (NSCLC) undergoing stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Using data from 65 treatment centers in the United States, we retrospectively reviewed the records of T1-2 N0 NSCLC patients undergoing SBRT alone from 2006 to 2014. Biologically relevant covariates, including dose per fraction, number of fractions, and time between fractions, were used to quantify BED10 and radiation treatment schedule...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27846900/4dct-and-cbct-based-ptv-margin-in-stereotactic-body-radiotherapy-sbrt-of-non-small-cell-lung-tumor-adhered-to-chest-wall-or-diaphragm
#8
Yi Li, Jing-Lu Ma, Xin Chen, Feng-Wen Tang, Xiao-Zhi Zhang
BACKGROUND: Large tumor motion often leads to larger treatment volumes, especially the lung tumor located in lower lobe and adhered to chest wall or diaphragm. The purpose of this work is to investigate the impacts of planning target volume (PTV) margin on Stereotactic Body Radiotherapy (SBRT) in non-small cell lung cancer (NSCLC). METHODS: Subjects include 20 patients with the lung tumor located in lower lobe and adhered to chest wall or diaphragm who underwent SBRT...
November 15, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27843029/stereotactic-body-radiation-therapy-and-the-influence-of-chemotherapy-on-overall-survival-for-large-%C3%A2-5-centimeter-non-small-cell-lung-cancer
#9
Vivek Verma, Matthew T McMillan, Surbhi Grover, Charles B Simone
PURPOSE: Stereotactic body radiation therapy (SBRT) for ≥5 cm lesions is poorly defined, largely owing to the low sample sizes in existing studies. The present analysis examined the SBRT outcomes and assessed the effect of chemotherapy in this population. METHODS AND MATERIALS: The National Cancer Data Base was queried for primary non-small cell lung cancer ≥5 cm treated with SBRT (≤10 fractions). Patient, tumor, and treatment parameters were extracted. The primary outcome was overall survival (OS)...
September 29, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27805837/dosimetric-factors-predicting-radiation-pneumonitis-after-cyberknife-stereotactic-body-radiotherapy-for-peripheral-lung-cancer
#10
Masaki Nakamura, Hideki Nishimura, Masao Nakayama, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Naoki Hashimoto, Yasuo Ejima, Takeaki Ishihara, Ryohei Sasaki
OBJECTIVE: The aims of this study were to investigate the frequency of symptomatic radiation pneumonitis (RP) after CyberKnife lung stereotactic body radiotherapy (SBRT) and to evaluate predictive factors of symptomatic RP. METHODS: 56 patients with peripheral non-small-cell lung cancer were treated using the CyberKnife(®) VSI(™) System (Accuracy Inc., Sunnyvale, CA) between May 2013 and September 2015. Total radiation doses ranged from 48 to 56 Gy, as delivered in four equal fractions...
December 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27798905/non-small-cell-lung-cancer-nsclc-in-octogenarians-in-clinical-practice
#11
Hirsh Koyi, Gunnar Hillerdal, Karl-Gustav Kölbeck, Daniel Brodin, Per Liv, Eva Brandén
BACKGROUND/AIM: Globally, an increasing proportion of cancer patients are aged >65 years and many are aged >70 years. Treatment of the elderly with lung cancer has, therefore, become an important issue. We performed a retrospective study of our patients to demonstrate how octogenarians with non-small cell lung cancer (NSCLC) are treated in real-life clinical practice. PATIENTS AND METHODS: This was a retrospective observational study of all elderly (≥80 years) patients with NSCLC referred to the Department of Respiratory Medicine and Allergy, Karolinska Hospital, Sweden, 2003-2010, and followed until June, 2016...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27787380/is-surgery-indicated-for-elderly-patients-with-early-stage-nonsmall-cell-lung-cancer-in-the-era-of-stereotactic-body-radiotherapy
#12
Nam P Nguyen, Juan Godinez, Wei Shen, Vincent Vinh-Hung, Helena Gorobets, Juliette Thariat, Fred Ampil, Jacqueline Vock, Ulf Karlsson, Alexander Chi
BACKGROUND: The aim of this article is to assess the influence of comorbidities among elderly patients (at least 70 year old) undergoing surgery for early stage nonsmall cell lung cancer (NSCLC) and to explore the tolerability and efficacy of surgery in relation to stereotactic body radiotherapy (SBRT) in this patient population. METHODS: A review of the literature on the prevalence of comorbidities among elderly patients with early stage NSCLC, and the impact of comorbidity factors on survival following surgery was conducted...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27751617/single-fraction-flattening-filter-free-volumetric-modulated-arc-therapy-for-lung-cancer-dosimetric-results-and-comparison-with-flattened-beams-technique
#13
Sara Barbiero, Alexandra Rink, Fabrizio Matteucci, David Fedele, Fabiola Paiar, Francesco Pasqualetti, Michele Avanzo
PURPOSE: To report on single-fraction stereotactic body radiotherapy (RT) (SBRT) with flattening filter (FF)-free (FFF) volumetric modulated arc therapy (VMAT) for lung cancer and to compare dosimetric results with VMAT with FF. METHODS AND MATERIALS: Overall, 25 patients were treated with 6-MV FFF VMAT (Varian TrueBeam STx LINAC) to a prescribed dose of 24Gy in a single fraction. Treatment plans were recreated using FF VMAT. Dose-volume indices, monitor units (MU), and treatment times were compared between FFF and FF VMAT techniques...
October 14, 2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/27745983/stereotactic-body-radiation-therapy-boost-after-concurrent-chemoradiation-for-locally-advanced-non-small-cell-lung-cancer-a-phase-1-dose-escalation-study
#14
Jaroslaw T Hepel, Kara Lynne Leonard, Howard Safran, Thomas Ng, Angela Taber, Humera Khurshid, Ariel Birnbaum, David E Wazer, Thomas DiPetrillo
PURPOSE: Stereotactic body radiation therapy (SBRT) boost to primary and nodal disease after chemoradiation has potential to improve outcomes for advanced non-small cell lung cancer (NSCLC). A dose escalation study was initiated to evaluate the maximum tolerated dose (MTD). METHODS AND MATERIALS: Eligible patients received chemoradiation to a dose of 50.4 Gy in 28 fractions and had primary and nodal volumes appropriate for SBRT boost (<120 cc and <60 cc, respectively)...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27741355/multi-institutional-experience-of-stereotactic-body-radiotherapy-for-large-%C3%A2-5-centimeters-non-small-cell-lung-tumors
#15
Vivek Verma, Valerie K Shostrom, Sameera S Kumar, Weining Zhen, Christopher L Hallemeier, Steve E Braunstein, John Holland, Matthew M Harkenrider, Adrian S Iskhanian, Hanmanth J Neboori, Salma K Jabbour, Albert Attia, Percy Lee, Fiori Alite, Joshua M Walker, John M Stahl, Kyle Wang, Brian S Bingham, Christina Hadzitheodorou, Roy H Decker, Ronald C McGarry, Charles B Simone
BACKGROUND: Stereotactic body radiotherapy (SBRT) is the standard of care for patients with nonoperative, early-stage non-small cell lung cancer (NSCLC) measuring < 5 cm, but its use among patients with tumors measuring ≥5 cm is considerably less defined, with the existing literature limited to small, single-institution reports. The current multi-institutional study reported outcomes evaluating the largest such population reported to date. METHODS: Clinical/treatment characteristics, outcomes, toxicities, and patterns of failure were assessed in patients with primary NSCLC measuring ≥5 cm without evidence of distant/lymph node metastasis who underwent SBRT using ≤5 fractions...
October 14, 2016: Cancer
https://www.readbyqxmd.com/read/27732993/radiation-therapy-for-stage-i-nonoperable-or-medically-inoperable-lung-cancer
#16
Amar U Kishan, Percy Lee
Non-small cell lung cancer (NSCLC) is the second most common solid malignancy in the United States of America, and the leading cause of cancer-related mortality. Nearly 15% of patients present with early-stage disease, for which the standard of care is lobectomy. However, the median age at diagnosis ranges from 65 to 74 years, and many patients have significant comorbidities that preclude surgical treatment. Previously, the standard of care for these patients was definitive radiotherapy (RT) with conventional fractionation (i...
October 2016: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27729942/vero%C3%A2-radiotherapy-for-low-burden-cancer-789-patients-with-957-lesions
#17
R Orecchia, A Surgo, M Muto, A Ferrari, G Piperno, M A Gerardi, S Comi, C Garibaldi, D Ciardo, A Bazani, F Golino, F Pansini, C Fodor, P Romanelli, D Maestri, V Scroffi, S Mazza, B A Jereczek-Fossa
PURPOSE: The aim of this retrospective study is to evaluate patient profile, feasibility, and acute toxicity of RadioTherapy (RT) delivered by VERO® in the first 20 months of clinical activity. METHODS: Inclusion criteria: 1) adult patients; 2) limited volume cancer (M0 or oligometastatic); 3) small extracranial lesions; 4) treatment between April 2012 and December 2013 and 5) written informed consent. Two techniques were employed: intensity modulated radiotherapy (IMRT) and stereotactic body radiotherapy (SBRT)...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27709851/comparison-of-dosimetric-performance-among-commercial-quality-assurance-systems-for-verifying-pretreatment-plans-of-stereotactic-body-radiotherapy-using-flattening-filter-free-beams
#18
Jin Beom Chung, Sang Won Kang, Keun Yong Eom, Changhoon Song, Kyoung Sik Choi, Tae Suk Suh
The purpose of this study was to compare the performance of different commercial quality assurance (QA) systems for the pretreatment verification plan of stereotactic body radiotherapy (SBRT) with volumetric arc therapy (VMAT) technique using a flattening-filter-free beam. The verification for 20 pretreatment cancer patients (seven lung, six spine, and seven prostate cancers) were tested using three QA systems (EBT3 film, I'mRT MatriXX array, and MapCHECK). All the SBRT-VMAT plans were optimized in the Eclipse (version 11...
November 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27709803/inter-scan-and-inter-observer-tumour-volume-delineation-variability-on-cone-beam-computed-tomography-in-patients-treated-with-stereotactic-body-radiation-therapy-for-early-stage-non-small-cell-lung-cancer
#19
Ying Hou, Stephanie Lee, Vishesh Agrawal, John Romano, Elizabeth H Baldini, Aileen B Chen, David E Kozono, Joseph H Killoran, Matthew Wagar, Fred L Hacker, Hugo Jwl Aerts, John H Lewis, Raymond H Mak
INTRODUCTION: Quantification of volume changes on cone beam computed tomography (CBCT) during lung stereotactic body radiation therapy (SBRT) for non-small cell lung cancer (NSCLC) may provide a useful radiological marker for radiation response and for adaptive treatment planning. This study quantifies inter-scan and inter-observer variability in tumour volume delineation on CBCT. METHODS: Three clinicians independently contoured the primary gross tumour volume (GTV) manually on CBCTs taken immediately before SBRT treatment (pre) and after the same SBRT treatment (post) for 19 NSCLC patients...
October 5, 2016: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/27681749/stereotactic-body-radiation-therapy-delivery-in%C3%A2-a%C3%A2-genetically-engineered-mouse-model-of%C3%A2-lung%C3%A2-cancer
#20
Shisuo Du, Virginia Lockamy, Lin Zhou, Christine Xue, Justin LeBlanc, Shonna Glenn, Gaurav Shukla, Yan Yu, Adam P Dicker, Dennis B Leeper, You Lu, Bo Lu
PURPOSE: To implement clinical stereotactic body radiation therapy (SBRT) using a small animal radiation research platform (SARRP) in a genetically engineered mouse model of lung cancer. METHODS AND MATERIALS: A murine model of multinodular Kras-driven spontaneous lung tumors was used for this study. High-resolution cone beam computed tomography (CBCT) imaging was used to identify and target peripheral tumor nodules, whereas off-target lung nodules in the contralateral lung were used as a nonirradiated control...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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