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https://www.readbyqxmd.com/read/29764593/-stereotactic-body-radiotherapy-for-centrally-located-non-small-cell-lung-cancer
#1
Yuming Wan, Jing Huang, Feng Xu
A few study has proven that about 90% of local control rates might be benefit from stereotactic body radiotherapy (SBRT) for patients with medically inoperable stage I non-small cell lung cancer (NSCLC), it is reported SBRT associated overall survival and tumor specific survival is comparable with those treated with surgery. SBRT has been accepted as the first line treatment for inoperable patients with peripheral located stage I NSCLC. However, the role of SBRT in centrally located lesions is controversial for potential toxic effects from the adjacent anatomical structure...
May 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29759332/sunset-stereotactic-radiation-for-ultracentral-non-small-cell-lung-cancer-a-safety-and-efficacy-trial
#2
Meredith Giuliani, Ashwathy S Mathew, Houda Bahig, Scott V Bratman, Edith Filion, Daniel Glick, Alexander V Louie, Srinivas Raman, Anand Swaminath, Andrew Warner, Vivian Yau, David Palma
BACKGROUND: Lung stereotactic body radiotherapy (SBRT) is considered a standard curative treatment for medically inoperable early stage non-small-cell lung cancer (NSCLC). Patients with ultracentral tumors (signifying tumors whose planning target volume touches or overlaps the central bronchial tree, esophagus, or pulmonary artery) may be at higher risk of serious toxicities such as bronchial stricture and collapse, esophageal strictures, tracheal-esophageal fistula, and hemorrhage. The primary objective of the study is to determine the maximum tolerated dose of radiotherapy for ultracentral NSCLC...
April 18, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29733909/radiosensitivity-of-lung-metastases-by-primary-histology-and-implications-for-stereotactic-body-radiation-therapy-using-the-genomically-adjusted-radiation-dose
#3
Kamran A Ahmed, Jacob G Scott, John A Arrington, Arash O Naghavi, G Daniel Grass, Bradford A Perez, Jimmy J Caudell, Anders E Berglund, Eric A Welsh, Steven A Eschrich, Thomas J Dilling, Javier F Torres-Roca
INTRODUCTION: We assessed the radiosensitivity of lung metastases based on primary histology using a validated gene signature and model lung metastases for the genomically adjusted radiation dose (GARD). METHODS: Tissue samples were identified from our prospective observational protocol. The radiosensitivity index (RSI) 10 gene assay was run on samples and calculated alongside GARD using the previously published algorithms. A cohort of 105 patients with 137 lung metastases treated with SBRT at our institution was used for clinical correlation...
May 4, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29724402/thoracic-reirradiation-with-sbrt-for-residual-recurrent-and-new-primary-nsclc-within-or-immediately-adjacent-to-a-prior-high-dose-radiation-field
#4
Zachary D Horne, Michael J Dohopolski, David A Clump, Steven A Burton, Dwight E Heron
PURPOSE: Local failure following concurrent chemoradiation and in-lobe failures following stereotactic body radiation therapy (SBRT) are common. We evaluated our institutional experience using SBRT as salvage in this setting. METHODS AND MATERIALS: Seventy-two patients were reirradiated with SBRT for residual, locally recurrent, or new primary non-small cell lung cancer within or adjacent to a high-dose external beam radiation therapy or SBRT field. Kaplan-Meier analysis with log-rank test were used to estimate endpoints and differentiate cohorts...
May 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29722662/a-retrospective-long-term-follow-up-study-of-stereotactic-body-radiation-therapy-for-non-small-cell-lung-cancer-from-a-single-institution-incidence-of-late-local-recurrence
#5
Takashi Shintani, Yukinori Matsuo, Yusuke Iizuka, Takamasa Mitsuyoshi, Takashi Mizowaki
PURPOSE: To assess the local recurrence (LR) rate and timing after stereotactic body radiation therapy (SBRT) for non-small cell lung cancer using long-term follow-up data from a single institution. METHODS AND MATERIALS: Patients with primary or recurrent non-small cell lung cancer with or without pathologic verification, with tumors <3 cm, treated with SBRT (isocenter prescription of 48 Gy in 4 fractions) between April 1998 and August 2014, and with >6 months' follow-up were eligible...
April 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29722594/stereotactic-body-radiotherapy-for-second-primary-lung-cancer-and-intra-parenchymal-lung-metastasis-in-patients-previously-treated-with-surgery-evaluation-of-indications-and-predictors-of-decreased-respiratory-function
#6
Takeaki Ishihara, Kazunari Yamada, Aya Harada, Haruhiro Yukiue, Masayuki Tanahashi, Hiroshi Niwa, Takashi Matsui, Koshi Yokomura, Yasuo Ejima, Ryohei Sasaki
BACKGROUND: The adaptation criteria for administration of stereotactic body radiotherapy (SBRT) to patients with lung cancer who previously underwent surgery and subsequently developed a second primary lung cancer (SPLC) or intra-parenchymal lung metastasis (IPLM) are controversial, unlike the criteria for repeat surgery. We aimed to evaluate the feasibility of SBRT for these patients. Factors associated with decreased respiratory function were also evaluated. MATERIAL AND METHODS: Sixty-nine patients with 89 lesions who underwent SBRT between 2008 and 2017 were analyzed...
May 3, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29707354/fiducial-marker-placement-for-stereotactic-body-radiation-therapy-via-convex-probe-endobronchial-ultrasound-a-case-series-and-review-of-literature
#7
REVIEW
Benjamin J Seides, John P Egan, Kim D French, Kevin L Kovitz, Neeraj R Desai
Convex probe endobronchial ultrasound (CP-EBUS) and stereotactic body radiotherapy (SBRT) are valuable tools in the diagnosis, staging, and treatment of thoracic malignancies. With widespread clinical adoption, novel uses of CP-EBUS beyond mediastinal diagnosis and staging continue to be discovered. SBRT is an attractive treatment strategy in early-stage lung cancer and oligo-metastatic disease of the chest when a surgical approach is either not feasible or desirable. Accurate application of SBRT is aided by the placement of radio-opaque fiducial markers (FM) to compensate for respiratory cycle movements...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29706462/cost-effectiveness-analysis-of-stereotactic-body-radiotherapy-and-surgery-for-medically-operable-early-stage-non-small-cell-lung-cancer
#8
Adrien Paix, Georges Noel, Pierre-Emmanuel Falcoz, Pierre Levy
BACKGROUND: Projections estimate an increase of 50% of the incidence of lung cancer by 2030. Early-stage non-small cell lung cancer represented 19% of NSCLC cases diagnosed in the US between 2005 and 2011. There is rising evidence in favour of lung cancer screening, which will reduce the occurrence of later-stage lung cancers while raising the incidence of early-stage NSCLC. Current guidelines state that for early-stage NSCLC, surgical resection should be performed, and stereotactic body radiotherapy (SBRT) is an option for patients who are non-medically operable...
April 26, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29697204/image-based-management-of-empiric-lung-stereotactic-body-radiotherapy-sbrt-without-biopsy-predictors-from-a-10-year-single-institution-experience
#9
Shaakir Hasan, Athanasios Colonias, Timothy Mickus, Matthew VanDeusen, Rodney E Wegner
BACKGROUND: There is emerging reliance on clinical imaging for the diagnosis, prognosis, and treatment evaluation of early stage non-small cell lung cancer (NSCLC) in patients deemed too high risk for biopsy. We report our experience of clinically diagnosed NSCLC treated empirically with stereotactic body radiotherapy (SBRT) to validate the imaging parameters used for management in this high-risk population. METHODS: We reviewed 101 empiric lung SBRT cases and profiled imaging specifics of computed tomography and positron emission tomography for diagnosis and follow-up...
April 26, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29695273/stereotactic-body-radiotherapy-for-central-lung-tumors-yes-we-can
#10
Yasmin Korzets Ceder, Eyal Fenig, Aron Popvtzer, Nir Peled, Mordechai R Kramer, Milton Saute, Dima Bragilovsky, Tzippy Schochat, Aaron M Allen
BACKGROUND: SBRT is standard therapy for early stage lung cancer. Toxicity in central tumors has been a concern. RTOG 0813 showed that central SBRT is safe and effective. We report our experience with central SBRT. METHODS: We reviewed the records of patients treated with SBRT for central lung tumors (< 2 cm of the carina). Patients included primary lung cancer and recurrence following surgery and\ or conventional radiotherapy. All patients underwent 4DCT simulation and treatment planning was done with IMRT or VMAT techniques...
April 25, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29688858/additional-chemotherapy-improved-local-control-and-overall-survival-after-stereotactic-body-radiation-therapy-for-patients-with-oligo-recurrence
#11
Masaki Nakamura, Naoki Hashimoto, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Ryo Nishikawa, Yoshiro Matsuo, Hiroki Kawaguchi, Hideki Nishimura
BACKGROUND: Oligo-recurrence has been considered to confer improved prognosis than other oligometastatic conditions, and stereotactic body radiation therapy (SBRT) is considered as an option of local therapy for lung or liver metastases. The purpose of this study was to investigate the efficacy and safety of SBRT for lung and liver oligo-recurrent lesions and evaluate predictive factors for local control and prognosis. METHODS: This retrospective study included patients who presented with 1-3 matachronous lung or liver metastases, and treated with SBRT between May 2013 and March 2016 at a single institution...
April 23, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29681240/pembrolizumab-combined-with-stereotactic-body-radiotherapy-in-a-patient-with-human-immunodeficiency-virus-and-advanced-non-small-cell-lung-cancer-a-case-report
#12
Dongqi Li, Chuanchun He, Yaoxiong Xia, Yaxi Du, Jing Zhang
BACKGROUND: Pembrolizumab has significantly improved outcomes in patients with advanced non-small cell lung cancer. Combining programmed death-1 inhibitor with stereotactic body radiotherapy showed a slight toxicity and good benefits in recent clinical trials. However, patients infected with human immunodeficiency virus were excluded from most trials because it was assumed that their anti-tumor immunity was compromised compared with immunocompetent patients. CASE PRESENTATION: In June 2016, a 52-year-old Chinese man presented with human immunodeficiency virus and lung adenocarcinoma (T1bN3M1b)...
April 23, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29680255/phase-2-study-of-stereotactic-body-radiation-therapy-and-stereotactic-body-proton-therapy-for-high-risk-medically-inoperable-early-stage-non-small-cell-lung-cancer
#13
Chonnipa Nantavithya, Daniel R Gomez, Xiong Wei, Ritsuko Komaki, Zhongxing Liao, Steven H Lin, Melenda Jeter, Quynh-Nhu Nguyen, Heng Li, Xiaodong Zhang, Falk Poenisch, X Ronald Zhu, Peter A Balter, Lei Feng, Noah C Choi, Radhe Mohan, Joe Y Chang
PURPOSE: To report the feasibility of conducting a randomized study to compare the toxicity and efficacy of stereotactic body radiation therapy (SBRT) versus stereotactic body proton therapy (SBPT) for high-risk, medically inoperable, early-stage non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: Patients with medically inoperable NSCLC with high-risk features (centrally located or <5 cm T3 tumor or isolated lung parenchymal recurrences) were randomly assigned to SBRT or SBPT...
March 2, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29661254/the-risk-and-predictors-for-severe-radiation-pneumonitis-in-lung-cancer-patients-treated-with-thoracic-reirradiation
#14
Chengbo Ren, Tianlong Ji, Tingting Liu, Jun Dang, Guang Li
BACKGROUND: Thoracic reirradiation (re-RT) is increasingly administered. However, radiation pneumonitis (RP) remains to be the most common side effect from retreatment. This study aimed to determine the risk and predictors for severe RP in patients receiving thoracic re-RT. METHODS: Sixty seven patients with lung cancer received thoracic re-RT for recurrent or metastatic disease. Three-dimensional conformal radiotherapy (3D-CRT)/intensity modulated radiotherapy (IMRT) was used for 60 patients, and stereotactic body radiation therapy (SBRT) was used in 7 patients...
April 16, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29656869/comparing-treatment-strategies-for-stage-i-small-cell-lung-cancer
#15
Peter Paximadis, Jennifer L Beebe-Dimmer, Julie George, Anne G Schwartz, Antoinette Wozniak, Shirish Gadgeel
INTRODUCTION: The diagnosis of stage I small-cell lung cancer (SCLC) is increasing in incidence with the advent of low-dose screening computed tomography. Surgery is considered the standard of care but there are very few data to guide clinical decision-making. The purpose of this study was to compare outcomes for patients receiving definitive surgery, stereotactic body radiation therapy (SBRT), or external beam radiation therapy (EBRT) for stage I SCLC. PATIENTS AND METHODS: Patients with a primary diagnosis of stage I SCLC were identified in the National Cancer Database...
March 23, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29644155/stereotactic-body-radiation-therapy-for-pulmonary-oligometastases-arising-from-non-lung-primaries-in-patients-without-extrapulmonary-disease
#16
Michael J Dohopolski, Zachary Horne, David Clump, Steven A Burton, Dwight E Heron
Purpose Stereotactic body radiation therapy (SBRT) is increasingly used in the management of patients with oligometastatic cancers and is under prospective evaluation by the Radiation Therapy Oncology Group (RTOG). Here we report outcomes from a high-volume institution of patients treated with SBRT for pulmonary oligometastases. Materials and methods We conducted a retrospective review of 105 patients who had one to five pulmonary oligometastases (185 lesions) without extrapulmonary disease treated with SBRT from 2002-2014...
February 7, 2018: Curēus
https://www.readbyqxmd.com/read/29616661/shell-feature-a-new-radiomics-descriptor-for-predicting-distant-failure-after-radiotherapy-in-non-small-cell-lung-cancer-and-cervix-cancer
#17
Hongxia Hao, Zhiguo Zhou, Shulong Li, Genevieve Maquilan, Michael R Folkert, Puneeth Iyengar, Kenneth D Westover, Kevin Albuquerque, Fang Liu, Hak Choy, Robert Timmerman, Lin Yang, Jing Wang
Distant failure is the main cause of human cancer-related mortalities. To develop a model for predicting distant failure in non-small cell lung cancer (NSCLC) and cervix cancer (CC) patients, a shell feature, consisting of outer voxels around the tumor boundary, was constructed using pre-treatment positron emission tomography (PET) images from 48 NSCLC patients received stereotactic body radiation therapy and 52 CC patients underwent external beam radiation therapy and concurrent chemotherapy followed with high-dose-rate intracavitary brachytherapy...
May 2, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29607173/dosimetric-comparison-of-helical-tomotherapy-and-conventional-linac-based-x-knife-stereotactic-body-radiation-therapy-for-primary-lung-cancer-or-pulmonary-metastases
#18
Shuangshuang Li, Ju Yang, Juan Liu, Shanbao Gao, Baorui Liu, Jing Yan
Background: To compare helical tomotherapy (HT) with X-knife stereotactic body radiation therapy (HT-SBRT/X-SBRT) for primary or metastatic lung cancer regarding planning target volume (PTV) coverage, such as homogeneity index (HI), conformity index (CI) and dose-volume histogram (DVH) of organs at risk (OARs). Methods: We retrospectively analyzed 21 patients receiving definitive radiation treatment for non-small cell lung cancer (NSCLC) or pulmonary metastases at our institution between March 2015 and October 2016...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29600055/clarithromycin-mitigates-radiation-pneumonitis-in-patients-with-lung-cancer-treated-with-stereotactic-body-radiotherapy
#19
Atsuya Takeda, Yuichiro Tsurugai, Naoko Sanuki, Tatsuji Enomoto, Masaharu Shinkai, Tomikazu Mizuno, Yousuke Aoki, Yohei Oku, Takeshi Akiba, Yu Hara, Etsuo Kunieda
Background: Radiation pneumonitis is a critical pulmonary toxicity after irradiation of the lung. Macrolides including clarithromycin (CAM) are antibiotics. They also have immunomodulatory properties and are used to treat respiratory inflammatory diseases. Radiation pneumonitis has similar pathology to them. Adverse reactions to macrolides are few and self-limited. We thus administered CAM to patients with high-risk factors for radiation pneumonitis, and retrospectively investigated whether CAM mitigated radiation pneumonitis following stereotactic body radiotherapy (SBRT)...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29594219/feasibility-of-stereotactic-body-radiotherapy-for-locally-advanced-non-small-cell-lung-cancer
#20
Katrina Woodford, Vanessa Panettieri, Trieumy Tran Le, Sashendra Senthi
SBRT was feasible for approximately half of the locally-advanced NSCLC patients we assessed and for these patients has the potential to reduce a 30 fraction course to 12 fractions. Using SBRT in this setting requires compromises in techniques and further compromises may allow SBRT in a greater proportion of patients.
October 2017: Clinical and Translational Radiation Oncology
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