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https://www.readbyqxmd.com/read/29672845/drug-induced-proarrhythmia-and-torsade-de-pointes-a-primer-for-students-and-practitioners-of-medicine-and-pharmacy
#1
REVIEW
J Rick Turner, Ignacio Rodriguez, Emily Mantovani, Gary Gintant, Peter R Kowey, Ralph J Klotzbaugh, Krishna Prasad, Philip T Sager, Norman Stockbridge, Colette Strnadova
Multiple marketing withdrawals due to proarrhythmic concerns occurred in the United States, Canada, and the United Kingdom in the late 1980s to early 2000s. This primer reviews the clinical implications of a drug's identified proarrhythmic liability, the issues associated with these safety-related withdrawals, and the actions taken by the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) and by regulatory agencies in terms of changing drug development practices and introducing new nonclinical and clinical tests to asses proarrhythmic liability...
April 19, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29669452/association-between-provider-specialty-and-healthcare-costs-and-glycemic-control-for-patients-with-diabetes
#2
Max Gill, Harmeet Chhabra, Mona Shah, Cyrus Zhu, Howard Lando, Felice Caldarella
AIMS: To analyze the association between provider, healthcare costs, and glycemic control for patients with diabetes mellitus (DM). MATERIALS AND METHODS: This cross-sectional study identified adults with type 1 or 2 DM (T1D, T2D) in the Optum database. The main independent variable was provider (endocrinologist or primary care). Regression analysis compared total medical and pharmacy costs, adjusting for health status and other patient differences, by provider...
April 19, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29665097/real-world-use-of-elbasvir-grazoprevir-in-patients-with-chronic-hepatitis-c-retrospective-analyses-from-the-trio-network
#3
S L Flamm, B Bacon, M P Curry, S Milligan, C U Nwankwo, N Tsai, Z Younossi, N Afdhal
BACKGROUND: Elbasvir-grazoprevir is indicated for chronic hepatitis C virus (HCV) genotypes 1 and 4. AIMS: To evaluate the utilization and outcomes of chronic HCV patients treated with elbasvir-grazoprevir in the United States. METHODS: We conducted a retrospective cohort study of adults treated with elbasvir-grazoprevir with or without ribavirin for chronic HCV genotypes 1 or 4 infection. Data were collected from healthcare providers and specialty pharmacies through Innervation Platform, a proprietary, cloud-based disease management program from Trio Health...
April 17, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29642733/warfarin-patients-with-anemia-show-trend-of-out-of-range-international-normalized-ratio-frequency-with-point-of-care-testing-in-an-anticoagulation-clinic
#4
Christina E DeRemer, Bliss McMichael, Henry N Young
INTRODUCTION: Many factors influence international normalized ratio (INR); however, few studies have examined the impact of anemia in warfarin patients. The primary objective of this study was to explore the relationship between in-clinic anemia and the control of INR within an anticoagulation clinic. METHODS: A retrospective chart review was performed on a random sample of patients seen in an academic medical center pharmacy-managed anticoagulation clinic. Hemochron® Signature Elite machine was utilized to monitor point-of-care (POC) INR...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29629476/health-and-health-care-access-for-syrian-refugees-living-in-%C3%A4-stanbul
#5
Perihan Torun, Meltem Mücaz Karaaslan, Büşra Sandıklı, Ceyda Acar, Ellyn Shurtleff, Sophia Dhrolia, Bülent Herek
OBJECTIVES: The study was conducted to assess the health needs of urban refugees living in İstanbul. METHODS: A mixed methods approach was adopted to interview Syrian women from households, doctors, decision makers and NGO representatives. The data were collected between June and October 2015. RESULTS: The main challenges were the cost of living in İstanbul, increased rent and language barrier. Almost half (49.6%) of the interviewed women did not know about free health care rights for Syrians...
April 9, 2018: International Journal of Public Health
https://www.readbyqxmd.com/read/29617486/-structure-of-primary-healthcare-units-for-treating-persons-with-diabetes-cycles-i-and-ii-of-the-brazilian-national-program-to-improve-access-and-quality
#6
Rosália Garcia Neves, Suele Manjourany Silva Duro, Javier Muñiz, Teresa Rosalia Pérez Castro, Luiz Augusto Facchini, Elaine Tomasi
The objective was to describe the necessary structure for treating diabetes patients in the primary healthcare system, as evaluated in Cycles I and II of the Brazilian National Program for the Improvement of Access and Quality (PMAQ) in 2012 and 2014, according to the municipalities' characteristics. A descriptive study was used to assess primary care units whose teams participated in Cycles I and II of the PMAQ in 2012 and 2014. The study used variables from Module I of the external evaluation of the PMAQ that addresses the primary care units' structure...
March 29, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29611088/the-impact-of-care-specialty-on-survival-adjusted-medical-costs-of-copd-patients-after-a-hospitalization-a-longitudinal-analysis
#7
Wenjia Chen, Don D Sin, J Mark FitzGerald, Mohsen Sadatsafavi
BACKGROUND: Little is known about the impact of care provider's specialty on the medical costs of COPD patients over time. OBJECTIVE: To compare the long-term medical costs between newly hospitalized COPD patients whose post-discharge care was initiated by a pulmonary specialist versus by a general practitioner. DESIGN: Retrospective matched cohort study. PARTICIPANTS: We identified patients with an incident COPD-related hospitalization from the administrative health database (January 1, 1996, to December 31, 2012) of British Columbia, Canada...
April 2, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29610252/enhancing-postdischarge-asthma-care-by-using-pharmacy-claims-and-telephone-follow-up
#8
Ronald J Teufel, Anita B Shuler, Myla D Ebeling, Kristen Morella, Annie L Andrews
BACKGROUND AND OBJECTIVES: Asthma is a common reason for hospital readmission. The majority of children are not receiving adequate preventive care after discharge. Our objective is to decrease return visits to the emergency department (ED) or hospital for asthma through a series of interventions (eg, access to real-time claims data and structured follow-up phone calls) designed to increase preventive care. METHODS: We performed a single-site quality improvement project for children 2 to 17 years old discharged with asthma from January 2010 to March 2014...
April 2, 2018: Hospital Pediatrics
https://www.readbyqxmd.com/read/29603802/paediatric-antiepileptic-polytherapy-systematic-review-of-efficacy-and-neurobehavioural-effects-and-a-tertiary-centre-experience
#9
D Plevin, J Jureidini, S Howell, N Smith
AIM: This paper presents the prevalence of antiepileptic polytherapy at a single tertiary institution and systematically reviews the evidence base for its efficacy and neurobehavioural safety in children. METHOD: Prevalence of antiepileptic polypharmacy was determined from pharmacy dispensing records at a paediatric tertiary hospital and neurobehavioural comorbidities quantified through casenote review; comparison is made with studies evaluating the neurobehavioural safety of antiepileptic polytherapy, identified via systematic literature review...
March 30, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29600808/anticholinergics-influence-transition-from-normal-cognition-to-mild-cognitive-impairment-in-older-adults-in-primary-care
#10
Noll L Campbell, Kathleen A Lane, Sujuan Gao, Malaz A Boustani, Fred Unverzagt
STUDY OBJECTIVE: To determine the influence of anticholinergic medications on transitions in cognitive diagnosis of older adults in primary care. DESIGN: This observational cohort study was conducted over a mean follow-up of 3.2 years. Anticholinergic exposure was defined by pharmacy dispensing and claims records. Cognitive diagnosis was performed by an expert panel at baseline and annually up to four years. DATA SOURCE: Medication exposure and other clinical data were extracted from the Indiana Network for Patient Care (INPC), while the cognitive diagnosis was derived from a cognitive screening and diagnosis study...
March 30, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29590242/-sources-of-medicines-for-chronic-patients-using-the-brazilian-unified-national-health-system
#11
Samara Ramalho Matta, Andréa Dâmaso Bertoldi, Isabel Cristina Martins Emmerick, Andréia Turmina Fontanella, Karen Sarmento Costa, Vera Lucia Luiza
The article aimed to identify the sources of medicines for users of the Brazilian Unified National Health System (SUS) that reported chronic non-communicable diseases, characterizing the group according to demographic, socioeconomic, and health variables in the different regions of Brazil. Data were analyzed from the National Survey on Access, Use, and Promotion of Rational Use of Medicines in Brazil (PNAUM), a cross-sectional population-based study. The dependent variable was "source of medicines", and the associations were analyzed with demographic, socioeconomic, and health status variables...
March 26, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29589821/the-2017-diabetes-educator-and-the-diabetes-self-management-education-national-practice-survey
#12
Joanne Rinker, Jane K Dickinson, Michelle L Litchman, Ann S Williams, Leslie E Kolb, Carla Cox, Ruth D Lipman
Purpose The American Association of Diabetes Educators conducts the National Practice Survey (NPS) biennially to document current practice in diabetes education in the United States. The purpose of the study is to obtain insight about factors influencing the work of the diabetes educator. Method The 2017 NPS was comprised of 100 questions covering diabetes educator demographics, profile populations of people with diabetes, practice information, program accreditation, program curriculum, staffing, education delivery methods, data collection, and reporting...
March 1, 2018: Diabetes Educator
https://www.readbyqxmd.com/read/29587742/availability-use-and-affordability-of-medicines-in-urban-china-under-universal-health-coverage-an-empirical-study-in-hangzhou-and-baoji
#13
Yunyu Huang, Youfen Jiang, Luying Zhang, Wenhui Mao, Job F M van Boven, Maarten J Postma, Wen Chen
BACKGROUND: This study aimed to examine the availability, use, and affordability of medicines in urban China following the 2009 Health Care System Reform that included implementation of universal health coverage (UHC). METHODS: This longitudinal study was performed in Hangzhou (high income, eastern China) and Baoji (lower income, western China). Five yearly household surveys were conducted (one each year from 2009 to 2013) to evaluate the impact of UHC on medicines use and expenditure, and a health facility survey was conducted in 2013 to evaluate availability of medicines...
March 27, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29587608/a-pilot-study-to-assess-the-pharmacy-impact-of-implementing-a-chemotherapy-induced-nausea-or-vomiting-collaborative-disease-therapy-management-in-the-outpatient-oncology-clinics
#14
Kasey Jackson, Cathy Letton, Andy Maldonado, Andrew Bodiford, Amy Sion, Rebekah Hartwell, Anastasia Graham, Carolyn Bondarenka, Lynn Uber
Background Collaborative drug therapy management is a formal partnership between a pharmacist and physician to allow the pharmacist to manage a patient's drug therapy. Literature supports collaborative disease therapy management can improve patient outcomes, improve medication adherence, enhance medication safety, and positively influence healthcare expenditures. Chemotherapy induced nausea or vomiting is considered one of the most distressing and feared adverse events among patients receiving chemotherapy...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29578854/increasing-access-to-hepatitis-c-virus-medications-a-program-model-using-patient-navigators-and-specialty-pharmacy-to-obtain-prior-authorization-approval
#15
Trang M Vu, Wilma Toribio, Farah Riazi, Genesis Ciprian, Nathalia Gibbs, Martha Giardina, Jocelyn A Camacho, Korin Parrella, Joy Cambe, Catherine Amory, Rachel Chasan, Keith M Sigel, Jeffrey J Weiss
BACKGROUND: Obtaining prior authorization (PA) approval for the new direct-acting antiviral (DAA) hepatitis C medications is time consuming and requires specific expertise. Our primary care-based program treats hepatitis C virus (HCV)-infected patients at an urban academic medical center and employs patient navigators trained in the PA process who collaborate with a nurse and specialty pharmacy to manage the PA process. OBJECTIVE: To demonstrate the rate of PA approvals for our programmatic model and determine potential predictors of PA approval...
April 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29578853/michigan-pharmacists-transforming-care-and-quality-developing-a-statewide-collaborative-of-physician-organizations-and-pharmacists-to-improve-quality-of-care-and-reduce-costs
#16
Hae Mi Choe, Alexandra Tungol Lin, Kathleen Kobernik, Marc Cohen, Laurie Wesolowicz, Nabeel Qureshi, Tom Leyden, David A Share, Rozanne Darland, David A Spahlinger
BACKGROUND: Inappropriate drug use, increasing complexity of drug regimens, continued pressure to control costs, and focus on shared accountability for clinical measures drive the need to leverage the medication expertise of pharmacists in direct patient care. A statewide strategy based on the collaboration of pharmacists and physicians regarding patient care was developed to improve disease state management and medication-related outcomes. PROGRAM DESCRIPTION: Blue Cross Blue Shield of Michigan (BCBSM) partnered with Michigan Medicine to develop and implement a statewide provider-payer program called Michigan Pharmacists Transforming Care and Quality (MPTCQ), which integrates pharmacists within physician practices throughout the state of Michigan...
April 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29577787/clinical-and-economic-outcomes-associated-with-the-use-of-fluticasone-propionate-250-mcg-and-salmeterol-50-mcg-combination-versus-tiotropium-bromide-18-mcg-as-initial-maintenance-treatment-for-chronic-obstructive-pulmonary-disease-in-managed-care
#17
Christopher F Bell, Anna D Coutinho, Eileen Farrelly, Tasneem Lokhandwala, Pamela Landsman-Blumberg
AIMS: To examine the clinical and economic outcomes associated with the use of long-acting bronchodilators for initial maintenance treatment of chronic obstructive pulmonary disease (COPD) by analyzing health insurance claims data in the United States. METHODS: A retrospective, observational, matched cohort study used health insurance claims data (January 2008 to June 2013) to assess COPD-related outcomes for subjects aged ≥40 years. Subjects were assigned to a study cohort according to the first observed prescription fill for a long-acting bronchodilator (fluticasone propionate 250 mcg/salmeterol 50 mcg [FSC] or tiotropium bromide 18 mcg [TIO])...
March 24, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29558338/integration-of-a-clinical-pharmacy-specialist-into-a-substance-use-disorder-intensive-outpatient-treatment-program-to-improve-prescribing-rates-of-alcohol-use-disorder-pharmacotherapy
#18
Erica Dimitropoulos, Stephanie Bertucci, Kara Wong
BACKGROUND: Research has demonstrated that the combination of pharmacotherapy and psychological interventions in alcohol use disorder (AUD) treatment is superior to either alone. Despite this, medications remain highly underutilized in many outpatient treatment facilities. Pharmacists can serve as an excellent resource to aid in improving access to medications. METHODS: This study was a prospective, longitudinal evaluation of a pharmacist's role in a substance use disorder (SUD) clinic, specifically an intensive outpatient program (IOP)...
March 20, 2018: Substance Abuse
https://www.readbyqxmd.com/read/29548304/coordinating-resources-for-prospective-medication-risk-management-of-older-home-care-clients-in-primary-care-procedure-development-and-rct-study-design-for-demonstrating-its-effectiveness
#19
Terhi Toivo, Maarit Dimitrow, Juha Puustinen, Eeva Savela, Katariina Pelkonen, Valtteri Kiuru, Tuula Suominen, Sirkka Kinnunen, Mira Uunimäki, Sirkka-Liisa Kivelä, Saija Leikola, Marja Airaksinen
BACKGROUND: The magnitude of safety risks related to medications of the older adults has been evidenced by numerous studies, but less is known of how to manage and prevent these risks in different health care settings. The aim of this study was to coordinate resources for prospective medication risk management of home care clients ≥ 65 years in primary care and to develop a study design for demonstrating effectiveness of the procedure. METHODS: Health care units involved in the study are from primary care in Lohja, Southern Finland: home care (191 consented clients), the public healthcare center, and a private community pharmacy...
March 16, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29537465/interprofessional-primary-care-course-curriculum-and-evaluation
#20
William R Phillips, Toby Keys
BACKGROUND AND OBJECTIVES: Primary care (PC) requires interprofessional teamwork and training. Although clinical training in PC settings is well developed in some professions, classroom teaching on the principles and practice of PC provides additional opportunities for interprofessional education. METHODS: We offered an elective one-credit classroom course on PC over 3 years, 2013 through 2015, enrolling students from dentistry, medicine, nursing, pharmacy, physician assistant, public health, social work, and other fields...
March 2018: Family Medicine
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