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Sympathetic skin response

Zuzana Visnovcova, Michal Mestanik, Michal Gala, Andrea Mestanikova, Ingrid Tonhajzerova
The aim of this study was to evaluate potential changes in the electrodermal activity (EDA) to enable the detection of variations in the sympathetic nervous system during mental load and recovery period. Several EDA parameters were used: SCA (skin conductance amplitude), frequency of NS-EDR (nonspecific electrodermal responses), SIE (symbolic information entropy), and ApEn (approximate entropy). The cohort consisted of 50 healthy students (average age: 23.33±0.24yr., 25 women). The stress profile consisted of five phases: baseline (P1), Stroop test (P2), recovery (P3), mental arithmetic test (P4), and recovery (P5)...
October 14, 2016: Computers in Biology and Medicine
Antonella Biasiotta, Daniela D'Arcangelo, Francesca Passarelli, Ezio Maria Nicodemi, Antonio Facchiano
BACKGROUND: Several cellular functions relate to ion-channels activity. Physiologically relevant chains of events leading to angiogenesis, cell cycle and different forms of cell death, require transmembrane voltage control. We hypothesized that the unordered angiogenesis occurring in solid cancers and vascular malformations might associate, at least in part, to ion-transport alteration. METHODS: The expression level of several ion-channels was analyzed in human solid tumor biopsies...
October 4, 2016: Journal of Translational Medicine
Emmanouil V Dermitzakis, Vasilios K Kimiskidis, George Lazaridis, Zoi Alexopoulou, Eleni Timotheadou, Alexandros Papanikolaou, Ourania Romanidou, George Georgiadis, Konstantine T Kalogeras, Iakovos Tsiptsios, Basil Tarlatzis, George Fountzilas
BACKGROUND: Paclitaxel-based regimens are frequently associated with the development of peripheral neuropathy. The autonomous nervous system (ANS) effects, however, of this chemotherapeutic agent remain unexplored. METHODS: We investigated a group of 31 female patients with ovarian cancer receiving treatment with paclitaxel and carboplatin, as well as a group of 16 healthy age- and gender-matched healthy volunteers. All study participants completed a questionnaire and were assessed neurophysiologically at three time points (baseline, 3-4 months and 6-8 months following the onset of chemotherapy)...
October 1, 2016: BMC Neurology
Maryam Abbaszadeh-Amirdehi, Noureddin Nakhostin Ansari, Soofia Naghdi, Gholamreza Olyaei, Mohammad Reza Nourbakhsh
BACKGROUND: Active myofascial trigger points (MTrPs) are major pain generators in myofascial pain syndrome. Dry needling (DN) is an effective method for the treatment of MTrPs. OBJECTIVE: To assess the immediate neurophysiological and clinical effects of DN in patients with upper trapezius MTrPs. METHODS: This was a prospective, clinical trial study of 20 patients with upper trapezius MTrPs and 20 healthy volunteers (matched for height, weight, body mass index and age), all of whom received one session of DN...
October 3, 2016: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
Oriel FeldmanHall, Paul Glimcher, Augustus L Baker, Elizabeth A Phelps
Uncertainty, which is ubiquitous in decision-making, can be fractionated into known probabilities (risk) and unknown probabilities (ambiguity). Although research has illustrated that individuals more often avoid decisions associated with ambiguity compared to risk, it remains unclear why ambiguity is perceived as more aversive. Here we examine the role of arousal in shaping the representation of value and subsequent choice under risky and ambiguous decisions. To investigate the relationship between arousal and decisions of uncertainty, we measure skin conductance response-a quantifiable measure reflecting sympathetic nervous system arousal-during choices to gamble under risk and ambiguity...
October 2016: Journal of Experimental Psychology. General
Liubov E Amirova, Nastassia M Navasiolava, Marie-Pierre Bareille, Arnaud Beck, Elena S Tomilovskaya, Inessa B Kozlovzkaya, Guillemette Gauquelin-Koch, Claude Gharib, Marc-Antoine Custaud
PURPOSE: Walking is a complex locomotor process that involves both spinal cord reflexes and cortical integration of peripheral nerve input. Maintaining an upright body position requires not only neuromuscular activity but also cardiovascular regulation. We postulated that plantar mechanical stimulation might modulate autonomic nervous system activity and, thereby, impact blood pressure adaptation during standing. METHODS: Twelve healthy subjects underwent three randomly ordered 45-min 70°-saddle tilt tests while the plantar surfaces of the feet were stimulated using specially engineered Korvit boots in the following modes: (1) no stimulation, (2) disrupted stimulation, and (3) walking mode...
September 29, 2016: European Journal of Applied Physiology
L J Peng, L L Mao, C F Bi, L P Li, W Yao, D Y Xia, Z W Wang, X K Qi, H R Qian
Objective: To provide evidence for early clinical diagnosis of multiple system atrophy(MSA)by studying the characteristics of sympathetic skin responses(SSR) in the patients with MSA. Methods: A total of 47 MSA patients and 32 healthy individuals were enrolled as case group and normal control(NC) group, from in and out patients of Neurology Department of Navy General Hospital from July 2013 to August 2015. SSR was tested by Nicolet electromyography, the latency and abnormal and disappeared rate of SSR were compared...
September 6, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Reza Bahador, Ahmadreza Mirbolook, Sara Arbab, Pooya Derakhshan, Amirmohammad Gholizadeh, Sadegh Abedi
BACKGROUND: Reflex sympathetic dystrophy (RSD) syndrome is a multifactorial disorder with clinical features of neurogenic inflammation that causes hypersensitivity to pain or severe allodynia as well as blood flow problems, swelling, skin discoloration and maladaptive neuroplasticity due to vasomotor disorders. Patients with major trauma are prone to homeostasis leading to inflammatory response syndrome and multiple organ distress syndrome. Several studies have investigated the etiology of this condition, but the cause remains unknown...
May 2016: Trauma Monthly
Timo Siepmann, Elka Frenz, Ana Isabel Penzlin, Susan Goelz, Wagner Zago, Ingeborg Friehs, Marie Luise Kubasch, Miriam Wienecke, Matthias Löhle, Wiebke Schrempf, Kristian Barlinn, Joachim Siegert, Alexander Storch, Heinz Reichmann, Ben Min-Woo Illigens
INTRODUCTION: Autonomic nervous system disturbances including sweating abnormalities and cardiovascular symptoms are frequent in Parkinson's disease (PD) and often precede motor involvement. Cholinergic vasomotor and sudomotor skin nerves are impaired in patients with PD even at early disease stages. We hypothesized that adrenergic pilomotor nerve function is similarly impaired in early PD and might constitute a novel diagnostic target. METHODS: We conducted a study in 12 PD patients (Hoehn&Yahr 1-2) and 12 healthy control subjects...
October 2016: Parkinsonism & related Disorders
Mark M Smits, Lennart Tonneijck, Marcel H A Muskiet, Trynke Hoekstra, Mark H H Kramer, Michaela Diamant, Erik H Serné, Daniël H van Raalte
OBJECTIVE: To assess the effects of glucagon-like peptide (GLP)-1-based therapies (ie, GLP-1 receptor agonists and dipeptidyl peptidase-4 inhibitors) on microvascular function in patients with type 2 diabetes mellitus. APPROACH AND RESULTS: We studied 57 patients with type 2 diabetes mellitus (mean±SD age: 62.8±6.9 years; body mass index: 31.8±4.1 kg/m(2); HbA1c [glycated hemoglobin] 7.3±0.6%) in an acute and 12-week randomized, placebo-controlled, double-blind trial conducted at the Diabetes Center of the VU University Medical Center...
October 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Janosch A Priebe, Miriam Kunz, Christian Morcinek, Peter Rieckmann, Stefan Lautenbacher
OBJECTIVE: Nociceptive abnormalities indicating increased pain sensitivity have been reported in patients with Parkinson's disease (PD). The disturbances are mostly responsive to dopaminergic (DA) treatment; yet, there are conflicting results. The objective of the present study was to investigate pain processing and nociception in PD patients in a more comprehensive manner than previous studies. For this purpose, a multi-methods approach was used in order to monitor different levels of the central nervous system (spinal, subcortical-vegetative, cortical)...
September 15, 2016: Journal of the Neurological Sciences
A Jekell, M Kalani, T Kahan
OBJECTIVE: To study whether reducing noradrenergic sympathetic vascular tone by doxazosin or blocking the renin-angiotensin-aldosterone system by ramipril will alter endothelial function in patients with uncomplicated hypertension. DESIGN AND METHOD: Mild-to-moderate hypertensive patients (age 54 ± 12 years, 34% women, blood pressure (BP) 148 ± 11/88 ± 9 mmHg) were randomized double-blind to ramipril (10 mg od, n = 33) or doxazosin (8 mg od, n = 28) for 12 weeks...
September 2016: Journal of Hypertension
Vijaita Syngle, Ashit Syngle, Nidhi Garg, Pawan Krishan, Inderjeet Verma
OBJECTIVE: Autonomic dysfunction occurs in rheumatoid arthritis (RA). However, the association between the autonomic dysfunction and inflammation has not been investigated in RA. We investigated the relationship between inflammation and ANS function in RA. METHODS: In this cross-sectional study, 25 RA patients and 25 age and sex-matched healthy controls were recruited. Autonomic function assessed by five cardiovascular reflex tests according to Ewing. Parasympathetic dysfunction established by applying three tests: heart rate response to deep breath (HRD) and standing (HRS) and Valsalva tests...
July 29, 2016: Autonomic Neuroscience: Basic & Clinical
A C Günther, A R Schandl, J Berhardsson, A Bjärtå, M Wållgren, Ö Sundin, J Alvarsson, M Bottai, C-R Martling, P V Sackey
BACKGROUND: Assessing pain in critically ill patients is difficult. Skin conductance variability (SCV), induced by the sympathetic response to pain, has been suggested as a method to identify pain in poorly communicating patients. However, SCV, a derivate of conventional skin conductance, could potentially also be sensitive to emotional stress. The purpose of the study was to investigate if pain and emotional stress can be distinguished with SCV. METHODS: In a series of twelve 1-min sessions with SCV recording, 18 healthy volunteers were exposed to standardized electric pain stimulation during blocks of positive, negative, or neutral emotion, induced with pictures from the International Affective Picture System (IAPS)...
September 2016: Acta Anaesthesiologica Scandinavica
Alexander R Burton, Azharuddin Fazalbhoy, Vaughan G Macefield
Acute pain triggers adaptive physiological responses that serve as protective mechanisms that prevent continuing damage to tissues and cause the individual to react to remove or escape the painful stimulus. However, an extension of the pain response beyond signaling tissue damage and healing, such as in chronic pain states, serves no particular biological function; it is maladaptive. The increasing number of chronic pain sufferers is concerning, and the associated disease burden is putting healthcare systems around the world under significant pressure...
2016: Frontiers in Neurology
Neeraj Kumar, Hardeep Singh Malhotra, Ravindra Kumar Garg, Rakesh Lalla, Kiran Preet Malhotra, Amita Jain, Imran Rizvi
OBJECTIVE: The diagnosis of leprous neuropathy is mostly empirical and electrophysiological studies may not truly represent the clinical findings. This study comprehensively evaluates the neuroelectrophysiology and looks at clinico-electrophysiological dissociation. METHODS: Conventional electrophysiological recording included evaluation of median, ulnar, radial, tibial, and common peroneal nerve; an extended protocol included great auricular, phrenic, and facial nerves, along with sympathetic skin response and blink reflex...
August 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Kumbhar Kartik Revanappa, Ranjith K Moorthy, Mathew Alexander, Vedantam Rajshekhar
BACKGROUND: There are sparse data on the recovery of sympathetic skin response (SSR) following decompressive surgery in patients with cervical spondylotic myelopathy (CSM). We designed a study to assess SSR in patients with moderate and severe (Nurick grades 3, 4 and 5) CSM, and its recovery following central corpectomy (CC). METHOD: We conducted a prospective study on 19 patients with moderate and severe CSM who underwent CC from June 2008 to December 2010. Autonomic dysfunction was defined as the presence of 'bladder dysfunction' or 'orthostatic hypotension'...
July 14, 2016: British Journal of Neurosurgery
Namiji Tokunaga, Kiyoko Fukai
AIM: Blanketing, which involves covering patients with a blanket in order to maintain their body temperature and privacy and help alleviate the stress that is associated with medical procedures, is a fundamental skill in nursing care. However, the actual therapeutic effects of blanketing have not been adequately investigated. Therefore, the aim of the present study was to clarify the psychosomatic effects of blanketing in nursing care by observing autonomic nervous activity. METHODS: This single-cohort, intra-participant, comparative cross-over study included 30 healthy female adolescents...
July 11, 2016: Japan Journal of Nursing Science: JJNS
Bárbara Isabel Roque Cunha Ferreira, José Luís Pio Da Costa Abreu, José Pedro Gaspar Dos Reis, Américo Manuel Da Costa Figueiredo
INTRODUCTION AND OBJECTIVE: Psoriasis is a chronic skin disease with a high impact on self-esteem and patients' health-related quality of life. In the last decades some studies have pointed out mental disorders associated with psoriasis and the etiopathogenic mechanisms behind that co-existence. This work compiles psychopathology associated with psoriasis and further analyzes the etiopathogenesis of psoriasis and mental disorders. METHODS: A systematic review of the literature was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and using the "5S" levels of organization of evidence from healthcare research, as previously described...
June 2016: Journal of Clinical and Aesthetic Dermatology
Geoffrey Burnstock
There is long-term (trophic) purinergic signalling involving cell proliferation, differentiation, motility and death in the development and regeneration of most systems of the body, in addition to fast purinergic signalling in neurotransmission, neuromodulation and secretion. It is not always easy to distinguish between short- and long-term signalling. For example, adenosine triphosphate (ATP) can sometimes act as a short-term trigger for long-term trophic events that become evident days or even weeks after the original challenge...
August 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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