Julie Sanceau, Lucie Poupel, Camille Joubel, Isabelle Lagoutte, Stefano Caruso, Sandra Pinto, Christèle Desbois-Mouthon, Cécile Godard, Akila Hamimi, Enzo Montmory, Cécile Dulary, Sophie Chantalat, Amélie Roehrig, Kevin Muret, Benjamin Saint-Pierre, Jean-François Deleuze, Sophie Mouillet-Richard, Thierry Forné, Christophe F Grosset, Jessica Zucman-Rossi, Sabine Colnot, Angélique Gougelet
The CTNNB1 gene, encoding β-catenin, is frequently mutated in hepatocellular carcinoma (HCC, ∼30%) and in hepatoblastoma (HB, >80%), in which DLK1/DIO3 locus induction is correlated with CTNNB1 mutations. Here, we aim to decipher how sustained β-catenin activation regulates DLK1/DIO3 locus expression and the role this locus plays in HB and HCC development in mouse models deleted for Apc (ApcΔhep ) or Ctnnb1-exon 3 (β-cateninΔExon3 ) and in human CTNNB1-mutated hepatic cancer cells...
February 3, 2024: Molecular Therapy