Yuki Taguchi, Takeo Nakaya, Kenichi Aizawa, Yoshiyuki Noguchi, Nobuhiko Maiya, Chisako Iwamoto, Kenichi Ohba, Minoru Sugawara, Masayuki Murata, Ryozo Nagai, Fumi Kano
The peptide mimetic, NC114, is a promising anticancer compound that specifically kills colorectal cancer cells without affecting normal colon epithelial cells. In our previous study, we observed that NC114 inhibited the Wnt/β-catenin pathway, with significant downregulation of both Ser 675-phosphorylated β-catenin and its target genes, cyclin D1 and survivin. However, the molecular mechanism responsible for its cytotoxic effect has not yet been fully characterized. In the present study, we demonstrated that NC114 prevented cell cycle progression from S to G2/M phase by downregulating cell cycle-related gene expression, and also induced growth arrest in SW480 and HCT-116 colorectal cancer cells...
March 1, 2024: FEBS Open Bio