keyword
https://read.qxmd.com/read/38218927/inhibition-of-linc00958-hinders-the-progression-of-osteoarthritis-through-regulation-of-the-mir-214-3p-foxm1-axis
#1
JOURNAL ARTICLE
Yingchuan Yin, Qiaojuan He, Jing He, Ying Feng, Yunyun Xu
OBJECTIVE: We investigated the impact of the long noncoding RNA LINC00958 on cellular activity and oxidative stress in osteoarthritis (OA). METHODS: We performed bioinformatics analysis via StarBase and luciferase reporter assays to predict and validate the interactions between LINC00958 and miR-214-3p and between miR-214-3p and FOXM1. The expression levels of LINC00958, miR-214-3p, and FOXM1 were measured by qRT-PCR and western blotting. To assess effects on CHON-001 cells, we performed MTT proliferation assays, evaluated cytotoxicity with a lactate dehydrogenase (LDH) assay, and examined apoptosis through flow cytometry...
January 13, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/37653539/persistent-hypoxia-promotes-myofibroblast-differentiation-via-gpr-81-and-differential-regulation-of-ldh-isoenzymes-in-normal-and-idiopathic-pulmonary-fibrosis-fibroblasts
#2
JOURNAL ARTICLE
Richard S Nho, Cami Rice, Jayendra Prasad, Hannah Bone, Laszlo Farkas, Mauricio Rojas, Jeffrey C Horowitz
Hypoxia, a state of insufficient oxygen availability, promotes cellular lactate production. Lactate levels are increased in lungs from patients with idiopathic pulmonary fibrosis (IPF), a disease characterized by excessive scar formation, and lactate is implicated in the pathobiology of lung fibrosis. However, the mechanisms underlying the effects of hypoxia and lactate on fibroblast phenotype are poorly understood. We exposed normal and IPF lung fibroblasts to persistent hypoxia and found that increased lactate generation by IPF fibroblasts was driven by the FoxM1-dependent increase of lactate dehydrogenase A (LDHA) coupled with decreased LDHB that was not observed in normal lung fibroblasts...
September 2023: Physiological Reports
https://read.qxmd.com/read/37564869/analysis-of-lactate-metabolism-related-genes-and-their-association-with-immune-infiltration-in-septic-shock-via-bioinformatics-method
#3
JOURNAL ARTICLE
Huimin Jiang, Yun Ren, Jiale Yu, Sheng Hu, Jihui Zhang
Background: Lactate, as an essential clinical evaluation index of septic shock, is crucial in the incidence and progression of septic shock. This study aims to investigate the differential expression, regulatory relationship, clinical diagnostic efficacy, and immune infiltration of lactate metabolism-related genes (LMGs) in septic shock. Methods: Two sepsis shock datasets (GSE26440 and GSE131761) were screened from the GEO database, and the common differentially expressed genes (DEGs) of the two datasets were screened out...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37406987/increased-%C3%AE-hb-links-colorectal-cancer-and-diabetes-by-potentiating-nf-%C3%AE%C2%BAb-signaling
#4
JOURNAL ARTICLE
Xinyue Lv, Peipei Ding, Luying Li, Ling Li, Danlei Zhou, Xiaochao Wang, Jianfeng Chen, Wei Zhang, Qi Wang, Tian Liao, Wenyu Wen, Dawang Zhou, Qing-Hai Ji, Xianghuo He, Qun-Ying Lei, Weiguo Hu
Sufficient evidence has linked many different types of cancers and T2D through shared risk factors; however, the underlying mechanisms are not fully understood. α-Hydroxybutyrate (α-HB), a byproduct metabolite increased in diabetes and cancer, including colorectal cancer (CRC), triggers lactate dehydrogenase A (LDHA) nuclear translocation. Nuclear LDHA markedly extends NF-κB nuclear retention by interacting with phosphorylated p65, leading to an increase in TNF-α production, impaired insulin secretion and the exacerbation of azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CRC and high-fat diet (HFD)-induced type 2 diabetes...
July 3, 2023: Molecular Metabolism
https://read.qxmd.com/read/37382415/btf3-promotes-proliferation-and-glycolysis-in-hepatocellular-carcinoma-by-regulating-glut1
#5
JOURNAL ARTICLE
Peng Wang, Jianmin Sun, Chengming Sun, Haoran Zhao, YuBao Zhang, Jing Chen
Hepatocellular carcinoma (HCC) is a grievous tumor with an increasing incidence worldwide. Basic transcription factor 3 (BTF3) is discovered to regulate the expression of glucose transporter 1 (GLUT1), which benefits glycolysis, a momentous signature of tumors, through transactivation of the forkhead box M1 (FOXM1) expression. BTF3 is highly expressed in HCC. However, whether BTF3 promotes GLUT1 expression through FOXM1 to modulate glycolysis in HCC remains unclear. The expression profile of BTF3 were determined by online database, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot...
December 31, 2023: Cancer Biology & Therapy
https://read.qxmd.com/read/37288731/apoptotic-and-anti-warburg-effect-of-morusin-via-ros-mediated-inhibition-of-foxm1-c-myc-signaling-in-prostate-cancer-cells
#6
JOURNAL ARTICLE
Ja Il Koo, Deok Yong Sim, Hyo-Jung Lee, Chi-Hoon Ahn, JiEon Park, Su-Yeon Park, Dain Lee, Bum-Sang Shim, Bonglee Kim, Sung-Hoon Kim
Though Morusin is known to induce apoptotic, antiprolifertaive, and autophagic effects through several signaling pathways, the underlying molecular mechanisms of Morusin still remain unclear until now. To elucidate antitumor mechanism of Morusin, cytotoxicity assay, cell cycle analysis, Western blotting, TUNEL assay, RNA interference, immunofluorescense, immunoprecipitation, reactive oxygen species (ROS) measurement, and inhibitor study were applied in this study. Morusin enhanced cytotoxicity, increased the number of TUNEL positive cells, sub-G1 population and induced the cleavages of PARP and caspase3, attenuated the expression of HK2, PKM2, LDH, c-Myc, and Forkhead Box M1 (FOXM1) along with the reduction of glucose, lactate, and ATP in DU145 and PC3 cells...
June 8, 2023: Phytotherapy Research: PTR
https://read.qxmd.com/read/35794249/foxm1-regulates-glycolysis-and-energy-production-in-multiple-myeloma
#7
JOURNAL ARTICLE
Yan Cheng, Fumou Sun, Krista Thornton, Xuefang Jing, Jing Dong, Grant Yun, Michael Pisano, Fenghuang Zhan, Sung Hoon Kim, John A Katzenellenbogen, Benita S Katzenellenbogen, Parameswaran Hari, Siegfried Janz
The transcription factor, forkhead box M1 (FOXM1), has been implicated in the natural history and outcome of newly diagnosed high-risk myeloma (HRMM) and relapsed/refractory myeloma (RRMM), but the mechanism with which FOXM1 promotes the growth of neoplastic plasma cells is poorly understood. Here we show that FOXM1 is a positive regulator of myeloma metabolism that greatly impacts the bioenergetic pathways of glycolysis and oxidative phosphorylation (OxPhos). Using FOXM1-deficient myeloma cells as principal experimental model system, we find that FOXM1 increases glucose uptake, lactate output, and oxygen consumption in myeloma...
August 2022: Oncogene
https://read.qxmd.com/read/35656815/foxm1-regulates-glycolysis-in-nasopharyngeal-carcinoma-cells-through-pdk1
#8
JOURNAL ARTICLE
Qing Yang, Fang Wu, Yong Zhang, Rensheng Wang
The transcription factor forkhead box M1 (FOXM1) is a well-known proto-oncogene that plays a significant role in the pathogenesis of various human cancers. However, the regulatory role and underlying mechanisms of FOXM1 in nasopharyngeal carcinoma (NPC) metabolism remain unclear. We demonstrated that FOXM1 could positively regulate glycolysis in NPC cells. Functional studies have shown that pyruvate dehydrogenase kinase 1 (PDK1) is involved in FOXM1-regulated lactate production, ATP generation and glycolysis...
July 2022: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/35546486/mfap2-aggravates-tumor-progression-through-activating-foxm1-%C3%AE-catenin-mediated-glycolysis-in-ovarian-cancer
#9
JOURNAL ARTICLE
Ling-Qin Zhao, Wei Sun, Ping Zhang, Wen Gao, Chen-Yan Fang, Ai-Wen Zheng
Ovarian cancer is one of the most common gynecological tumors that seriously endanger the health and quality of life of women. Microfibril-associated protein 2 (MFAP2) has been demonstrated to play crucial roles in the development of multiple tumors. However, the function of MFAP2 in ovarian cancer remains unclear. In this study, we found that MFAP2 was upregulated in ovarian cancer and cells and was positively correlated with FOXM1 and glycolysis-related genes. The results of Cell Count Kit-8, colony formation, and flow cytometry assays indicated that MFAP2 promoted cell proliferation...
August 2022: Kaohsiung Journal of Medical Sciences
https://read.qxmd.com/read/35313071/drp1-contributes-to-head-and-neck-cancer-progression-and-induces-glycolysis-through-modulated-foxm1-mmp12-axis
#10
JOURNAL ARTICLE
Tai-Lin Huang, Chuang-Rung Chang, Chih-Yen Chien, Gong-Kai Huang, Yi-Fan Chen, Li-Jen Su, Hsin-Ting Tsai, Yu-Sheng Lin, Fu-Min Fang, Chang-Han Chen
Abnormal DRP1 expression has been identified in a variety of human cancers. However, the prognostic potential and mechanistic role of DRP1 in head and neck cancer (HNC) are currently poorly understood. Here, we demonstrated a significant upregulation of DRP1 in HNC tissues, and that DRP1 expression correlates with poor survival of HNC patients. Diminished DRP1 expression suppressed tumor growth and metastasis in both in vitro and in vivo models. DRP1 expression was positively correlated with FOXM1 and MMP12 expression in HNC patient samples, suggesting pathological relevance in the context of HNC development...
July 2022: Molecular Oncology
https://read.qxmd.com/read/34742305/circ-rnf121-regulates-tumor-progression-and-glucose-metabolism-by-mir-1224-5p-foxm1-axis-in-colorectal-cancer
#11
JOURNAL ARTICLE
Zhipeng Jiang, Hao Hu, Wenli Hu, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang, Shuang Chen
AIM: Previous studies have reported that circular RNA (circRNA) is associated with the pathogenesis of CRC. This study was designed to reveal the mechanism of circ-ring finger protein 121 (circ-RNF121) in colorectal cancer (CRC). MATERIALS AND METHODS: The levels of circ-RNF121, microRNA-1224-5p (miR-1224-5p) and forkhead box M1 (FOXM1) were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Protein level was detected by western blot. Cell proliferation was analyzed by 3-(4,5-Dimethylthazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and cell colony formation assays...
November 6, 2021: Cancer Cell International
https://read.qxmd.com/read/34740322/nox4-derived-ros-induced-overexpression-of-foxm1-regulates-aerobic-glycolysis-in-glioblastoma
#12
JOURNAL ARTICLE
Xiangsheng Su, Yihang Yang, Qing Yang, Bo Pang, Shicheng Sun, Yanjun Wang, Qiujiang Qiao, Changfa Guo, Huanting Liu, Qi Pang
BACKGROUND: Increased expression of the transcription factor Forkhead box M1 (FOXM1) has been reported to play an important role in the progression and development of multiple tumors, but the molecular mechanisms that regulate FOXM1 expression remain unknown, and the role of FOXM1 in aerobic glycolysis is still not clear. METHODS: The expression of FOXM1 and NADPH oxidase 4 (NOX4) in normal brain tissues and glioma was detected in data from the TCGA database and in our specimens...
November 5, 2021: BMC Cancer
https://read.qxmd.com/read/34414414/hsa_circ_0023990-promotes-tumor-growth-and-glycolysis-in-dedifferentiated-tc-via-targeting-mir-485-5p-foxm1-axis
#13
JOURNAL ARTICLE
Qing Zhang, Lian Wu, Shao-Zheng Liu, Qing-Jie Chen, Ling-Peng Zeng, Xue-Zhong Chen, Qing Zhang
BACKGROUND: During the transformation to dedifferentiated TC types, the ability of papillary thyroid carcinomas (PTC) to concentrate radioactive iodine might be lost, raising difficulty for the current therapy. Circular RNAs (circRNAs) were proved to be implicated in the progression of various cancers. In this study, we aimed to investigate the functional role and mechanism of hsa_circ_0023990 in dedifferentiated TC. METHODS: The expression pattern of genes were detected utilizing qPCR or western blot assays...
August 20, 2021: Endocrinology
https://read.qxmd.com/read/34403223/upregulation-of-foxm1-protects-against-ischemia-reperfusion-induced-myocardial-injury
#14
JOURNAL ARTICLE
Gang Zhang, Kun Yu, Zhi Bao, Xiaofeng Sun, Dongying Zhang
BACKGROUND: Ischemia/reperfusion (I/R) induced lethal tissue injury in myocardium. FoxM1 (Forkhead Box M1), expressed in proliferating cardiac progenitor cells, could regulate myocardial development. However, the role of FoxM1 in I/R-induced myocardial injury has not been reported yet. METHODS: Rats were conducted with regional ischemia followed by reperfusion in myocardium through ligation of the left anterior descending coronary artery. Triphenyl-tetrazolium chloride staining was utilized to assess the infarct size...
August 17, 2021: Acta Biochimica Polonica
https://read.qxmd.com/read/33616859/uchl3-promotes-aerobic-glycolysis-of-pancreatic-cancer-through-upregulating-ldha-expression
#15
JOURNAL ARTICLE
Y Fan, D Hu, D Li, C Ma, Y Tang, Q Tao, L Deng, D Tang
BACKGROUND: Aerobic glycolysis has a pivotal role in the carcinogenic process. The current understanding of the functional role and mechanism of UCHL3-related aerobic glycolysis in pancreatic cancer is far from comprehensive, therefore requires an in-depth analysis on this aspect. METHODS: In the present research, the expressions of ubiquitin carboxyl-terminal hydrolase L3 (UCHL3), lactate dehydrogenase A (LDHA) and Forkhead box protein M1 (FOXM1) were detected by qRT-PCR, Western blot and immunohistochemistry...
February 22, 2021: Clinical & Translational Oncology
https://read.qxmd.com/read/33506582/propofol-suppresses-lung-cancer-tumorigenesis-by-modulating-the-circ-erbb2-mir-7-5p-foxm1-axis
#16
JOURNAL ARTICLE
Jie Gao, Chengzhi Ding, Junhui Zhou, Gang Wu, Zongmao Han, Jianchao Li, Feilong Hei
BACKGROUND: Propofol is a commonly used anesthetic for cancer surgery. Previous studies have shown that propofol has an anticancer role in various cancers, including lung cancer. This study aimed to investigate the role of propofol in lung cancer and its underlying mechanism. METHODS: Cell proliferation was determined by cell counting kit-8 (CCK-8) and colony formation assays. Flow cytometry and transwell assays were used to detect cell apoptosis and invasion, respectively...
January 27, 2021: Thoracic Cancer
https://read.qxmd.com/read/33261854/lncrna-hoxa11-as-aggravates-keloid-progression-by-the-regulation-of-hoxa11-as-mir-205-5p-foxm1-pathway
#17
JOURNAL ARTICLE
Xiaoguang Su, Yaohui Ma, Qing Wang, Yanjun Gao
BACKGROUND: Keloid is troublesome for patients' skin appearance and mental health, although it is a benign tumor. Long noncoding RNA (lncRNA) troubling keloid is frequently reported. The purpose of this study was to investigate the role of lncRNA homeobox (HOX) A11 antisense (HOXA11-AS) and related action mechanisms during the development of keloid. METHODS: The expression of HOXA11-AS, miR-205-5p, and forkhead box M1 (FOXM1) was measured by quantitative real-time polymerase chain reaction (qRT-PCR)...
November 28, 2020: Journal of Surgical Research
https://read.qxmd.com/read/33049205/lactate-lights-up-pi3k-inhibitor-resistance-in-breast-cancer
#18
COMMENT
Alissandra L Hillis, Alex Toker
Predictive biomarkers can facilitate optimal patient selection for targeted cancer therapies. In this issue of Cancer Cell, Ros et al. show the utility of noninvasive metabolic imaging of labeled carbon transfer from pyruvate to lactate to detect early response and FOXM1-mediated resistance to PI3K inhibition in estrogen-receptor-positive breast cancer.
October 12, 2020: Cancer Cell
https://read.qxmd.com/read/32976773/metabolic-imaging-detects-resistance-to-pi3k%C3%AE-inhibition-mediated-by-persistent-foxm1-expression-in-er-breast-cancer
#19
JOURNAL ARTICLE
Susana Ros, Alan J Wright, Paula D'Santos, De-En Hu, Richard L Hesketh, Yaniv Lubling, Dimitra Georgopoulou, Giulia Lerda, Dominique-Laurent Couturier, Pedram Razavi, Rapahel Pelossof, Ankita S Batra, Elizabeth Mannion, David Y Lewis, Alistair Martin, Richard D Baird, Mafalda Oliveira, Leonora W de Boo, Sabine C Linn, Maurizio Scaltriti, Oscar M Rueda, Alejandra Bruna, Carlos Caldas, Kevin M Brindle
PIK3CA, encoding the PI3Kα isoform, is the most frequently mutated oncogene in estrogen receptor (ER)-positive breast cancer. Isoform-selective PI3K inhibitors are used clinically but intrinsic and acquired resistance limits their utility. Improved selection of patients that will benefit from these drugs requires predictive biomarkers. We show here that persistent FOXM1 expression following drug treatment is a biomarker of resistance to PI3Kα inhibition in ER+ breast cancer. FOXM1 drives expression of lactate dehydrogenase (LDH) but not hexokinase 2 (HK-II)...
October 12, 2020: Cancer Cell
https://read.qxmd.com/read/32860508/lncrna-mcf2l-as1-aggravates-proliferation-invasion-and-glycolysis-of-colorectal-cancer-cells-via-the-crosstalk-with-mir-874-3p-foxm1-signaling-axis
#20
JOURNAL ARTICLE
Zhandong Zhang, Wei Yang, Ning Li, Xiaobin Chen, Fei Ma, Jian Yang, Yonglei Zhang, XiaoFei Chai, Bin Zhang, Xinfang Hou, Suxia Luo, Yawei Hua
Long non-coding RNAs (lncRNAs) regulate a series of biological processes, and their anomalous expression exerts critical roles in progression of multiple malignancies, including colorectal cancer (CRC). The present study was designed to provide new ideas and perspectives for the role of lncRNA MCF2L-AS1 and disclose the underlying mechanism in CRC. Herein, we observed that MCF2L-AS1 expression was enriched in CRC tissues and cell lines. Additionally, silencing of MCF2L-AS1 dramatically impeded cell proliferation, invasion and migration capacities of CRC, and distinctly attenuated the expression of invasion associated targets MMP-2 and MMP-9...
August 29, 2020: Carcinogenesis
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