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FoxM1 AND Lactate

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https://www.readbyqxmd.com/read/26563366/stat3-foxm1-and-mct1-drive-uterine-cervix-carcinoma-fitness-to-a-lactate-rich-microenvironment
#1
Lidia Santos Silva, Luis Gafeira Goncalves, Fernanda Silva, Germana Domingues, Valdemar Maximo, Joana Ferreira, Eric W-F Lam, Sergio Dias, Ana Felix, Jacinta Serpa
Uterine cervix cancer is the second most common malignancy in women worldwide with human papillomavirus (HPV) as the etiologic factor. The two main histological variants, squamous cell carcinomas (SCC) and adenocarcinomas (AC), resemble the cell morphology of exocervix and endocervix, respectively. Cancer metabolism is a cancer hallmark conditioned by the microenvironment. As uterine cervix homeostasis is dependent on lactate, we hypothesized lactate plays a role in uterine cervix cancer progression. Using in vitro (SiHa-SCC and HeLa-AC) and BALB-c/SCID models, we demonstrated that lactate metabolism is linked to histological types, with SCC predominantly consuming and AC producing lactate...
April 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26261559/foxm1-ldha-signaling-promoted-gastric-cancer-glycolytic-phenotype-and-progression
#2
Weihua Jiang, Fei Zhou, Ning Li, Qi Li, Liwei Wang
The oncogenic transcription factor forkhead box protein M1 (FOXM1) plays critical roles in gastric cancer (GC) development and progression. However, the underlying mechanisms has not fully demonstrated. Lactate dehydrogenase A (LDHA) is widely overexpressed in a series of cancers and is one of the two subunits of Lactate dehydrogenase (LDH), which is the key glycolytic enzyme and catalyzes the interconversion of pyruvate and lactate. In this study, we characterized the regulation of aerobic glycolysis by FOXM1 via transactivation of LDHA in GC...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/24634381/foxm1-promotes-the-warburg-effect-and-pancreatic-cancer-progression-via-transactivation-of-ldha-expression
#3
Jiujie Cui, Min Shi, Dacheng Xie, Daoyan Wei, Zhiliang Jia, Shaojiang Zheng, Yong Gao, Suyun Huang, Keping Xie
PURPOSE: The transcription factor Forkhead box protein M1 (FOXM1) plays critical roles in cancer development and progression. However, the regulatory role and underlying mechanisms of FOXM1 in cancer metabolism are unknown. In this study, we characterized the regulation of aerobic glycolysis by FOXM1 and its impact on pancreatic cancer metabolism. EXPERIMENTAL DESIGN: The effect of altered expression of FOXM1 on expression of glycolytic enzymes and tumor development and progression was examined using animal models of pancreatic cancer...
May 15, 2014: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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