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https://www.readbyqxmd.com/read/28813011/insights-into-the-effect-of-the-g245s-single-point-mutation-on-the-structure-of-p53-and-the-binding-of-the-protein-to-dna
#1
Marco Gaetano Lepre, Sara Ibrahim Omar, Gianvito Grasso, Umberto Morbiducci, Marco Agostino Deriu, Jack A Tuszynski
The transcription factor p53 is a potent tumor suppressor dubbed as the "guardian of the genome" because of its ability to orchestrate protective biological outputs in response to a variety of oncogenic stresses. Mutation and thus inactivation of p53 can be found in 50% of human tumors. The majority are missense mutations located in the DNA binding region. Among them, G245S is known to be a structural hotspot mutation. To understand the behaviors and differences between the wild-type and mutant, both a dimer of the wild type p53 (wt-p53) and its G245S mutant (G245S-mp53), complexed with DNA, were simulated using molecular dynamics for more than 1 μs...
August 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28812326/effect-of-dietary-components-from-antarctic-krill-on-atherosclerosis-in-apoe-deficient-mice
#2
Cinzia Parolini, Bodil Bjorndal, Marco Busnelli, Stefano Manzini, Giulia S Ganzetti, Federica Dellera, Marie Ramsvik, Inge Bruheim, Rolf Kristian Berge, Giulia Chiesa
SCOPE: Antarctic krill is a great source of n-3 fatty acids and high-quality proteins. Aim of the study was to evaluate the effect of Antarctic krill components on plasma lipids and atherosclerosis development. METHODS AND RESULTS: Sixty apoEKO mice were divided into four groups and fed Western diet (CONTROL) or Western-like diets, differing for protein or fat content. Specifically, casein or fat in CONTROL was partially replaced by krill proteins (PRO), krill oil (KRILL OIL), or both (KRILL OIL+PRO)...
August 15, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28812116/slco1b1-521t%C3%A2-%C3%A2-c-polymorphism-associated-with-rosuvastatin-induced-myotoxicity-in-chinese-coronary-artery-disease-patients-a-nested-case-control-study
#3
Ju-E Liu, Xiao-Ying Liu, Sheng Chen, Yan Zhang, Li-Yun Cai, Min Yang, Wei-Hua Lai, Bin Ren, Shi-Long Zhong
PURPOSE: This nested case-control study aimed to evaluate the association of candidate genetic variants with statin-induced myotoxicity in Chinese patients with coronary artery disease (CAD). METHODS: One hundred forty-eight Chinese patients experiencing statin-induced myotoxicity were included in our study, and 255 patients without muscular side effects served as controls. Five SNPs in CYP3A5, SLCO1B1, and APOE were genotyped. The effect of genetic variants on statin-induced myotoxicity was assessed...
August 15, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28811778/effects-of-blood-lipid-stability-on-progression-of-carotid-atherosclerosis
#4
Yu Ding, Bo Li, Feng Tian, Shanshan Zhou, Yundai Chen
OBJECTIVE: To evaluate the effects of blood lipid stability on progression of carotid atherosclerosis. METHODS: A total of 416 patients who had physical examination in our hospital annually from January 2010 to December 2015 were selected and divided into a progression group (n=216) and a non-progression group (n=200) according to the intima-media thickness measured by carotid ultrasound. The levels of lipid-related parameters within five years were retrospectively analyzed to calculate the smoothness index (SI = x±/s)...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811208/macromolecular-crowding-induces-molten-globule-state-in-the-native-myoglobin-at-physiological-ph
#5
Khalida Nasreen, Shahzaib Ahamad, Faizan Ahmad, Md Imtaiyaz Hassan, Asimul Islam
Here, we report the formation of molten globule state of the native myoglobin in crowded environment. We have used Soret absorption spectroscopy and far-UV circular dichroism to monitor changes in tertiary and secondary structures of myoglobin, respectively. Our results reveal that in the presence of ficoll 70, the secondary structure of myoglobin remains unchanged while tertiary structure is lost significantly. 1-anilinonaphthalene-8-sulfonate binding experiments showed that myoglobin in the presence of various concentrations of ficoll 70, has newly exposed hydrophobic surfaces...
August 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28810853/acute-effects-of-reducing-sitting-time-in-adolescents-a-randomized-cross-over-study
#6
Anisse Penning, Anthony D Okely, Stewart G Trost, Jo Salmon, Dylan P Cliff, Marijka Batterham, Steven Howard, Anne-Maree Parrish
BACKGROUND: Levels of sitting among adolescents are high, especially during the school day. The acute cognitive and health consequences associated with prolonged sitting are poorly understood in adolescents. This randomized crossover design study examined the acute effects of a simulated school day with reduced sitting or usual sitting on adolescents' cognitive function and cardiometabolic biomarkers. METHODS: Eighteen healthy school aged adolescents were recruited from the community to the study (11 males; 7 females; mean age [SD] = 13...
August 15, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28809725/clinical-characteristics-and-complications-of-pediatric-liver-biopsy-a-single-centre-experience
#7
Patricia Almeida, Richard A Schreiber, Jennifer Liang, Quais Mujawar, Orlee R Guttman
INTRODUCTION: Percutaneous liver biopsy (LB) is the gold standard method for evaluation and management of patients with liver disease. The purpose of this study was to characterize pediatric patients undergoing LB at British Columbia Children's Hospital, and to determine the rate and timing of complications following the procedure. MATERIAL AND METHODS: The medical records of all pediatric patients who underwent LB during a six-year retrospective study were reviewed to collect demographic and procedure-related data...
August 8, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28809398/precision-medicine-for-suicidality-from-universality-to-subtypes-and-personalization
#8
A B Niculescu, H Le-Niculescu, D F Levey, P L Phalen, H L Dainton, K Roseberry, E M Niculescu, J O Niezer, A Williams, D L Graham, T J Jones, V Venugopal, A Ballew, M Yard, T Gelbart, S M Kurian, A Shekhar, N J Schork, G E Sandusky, D R Salomon
Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders. Objective and precise identification of individuals at risk, ways of monitoring response to treatments and novel preventive therapeutics need to be discovered, employed and widely deployed. We sought to investigate whether blood gene expression biomarkers for suicide (that is, a 'liquid biopsy' approach) can be identified that are more universal in nature, working across psychiatric diagnoses and genders, using larger cohorts than in previous studies...
August 15, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28808293/targeting-apolipoprotein-e-amyloid-%C3%AE-binding-by-peptoid-cpo_a%C3%AE-17-21%C3%A2-p-ameliorates-alzheimer-s-disease-related-pathology-and-cognitive-decline
#9
Shan Liu, Shinae Park, Grant Allington, Frances Prelli, Yanjie Sun, Mitchell Martá-Ariza, Henrieta Scholtzova, Goutam Biswas, Bernard Brown, Philip B Verghese, Pankaj D Mehta, Yong-Uk Kwon, Thomas Wisniewski
Inheritance of the apolipoprotein E4 (apoE4) genotype has been identified as the major genetic risk factor for late onset Alzheimer's disease (AD). Studies have shown that apoE, apoE4 in particular, binds to amyloid-β (Aβ) peptides at residues 12-28 of Aβ and this binding modulates Aβ accumulation and disease progression. We have previously shown in several AD transgenic mice lines that blocking the apoE/Aβ interaction with Aβ12-28 P reduced Aβ and tau-related pathology, leading to cognitive improvements in treated AD mice...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808185/establishment-of-a-rat-model-with-diet-induced-coronary-atherosclerosis
#10
Mingming Gao, Guo Xin, Xu Qiu, Yuhui Wang, George Liu
Coronary atherosclerotic disease is a serious disease in humans, but no suitable animal model is available currently for further studies. We used apolipoprotein E gene knockout (ApoE KO) rats to induce hypercholesterolemia through a special high cholesterol/bile salt diet (Paigen diet), then analyzed aortic and coronary atherosclerosis lesions and the myocardial injury in order to establish a novel small animal model of coronary atherosclerosis. Plasma cholesterol of ApoE KO rats increased 7.6-fold compared with wild-type rats after 8 weeks on the Paigen diet...
October 17, 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28807493/homocysteine-and-cognitive-function-in-parkinson-s-disease
#11
Nicole Licking, Charles Murchison, Brenna Cholerton, Cyrus P Zabetian, Shu-Ching Hu, Thomas J Montine, Amie L Peterson-Hiller, Kathryn A Chung, Karen Edwards, James B Leverenz, Joseph F Quinn
INTRODUCTION: Increased plasma homocysteine (HC) is a risk factor for dementia in the general population. Levodopa therapy causes increased plasma HC, but it remains unclear whether elevated plasma HC is associated with cognitive impairment in Parkinson's disease (PD). METHODS: The study population includes all participants in the Pacific Northwest Udall Center (PANUC) Clinical cohort at the time of the study, consisting of 294 individuals with PD who had a standardized neuropsychological assessment and plasma collection for HC measurement...
August 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28804682/effects-of-intensive-pitavastatin-therapy-on-glucose-control-in-patients-with-non-st-elevation-acute-coronary-syndrome
#12
Yan-Bo Wang, Xiang-Hua Fu, Xin-Shun Gu, Wei-Ze Fan, Yun-Fa Jiang, Guo-Zhen Hao, Qing Miao, Jie Cao, Bing Fu, Yi Li
Objective: This study aimed to investigate the effects of intensive pitavastatin therapy on glucose control in patients with non-ST elevation acute coronary syndrome (ACS). Methods: Patients who had ACS with significant stenosis on initial coronary angiography and received successful percutaneous coronary intervention (PCI) in the Second Hospital of Hebei Medical University, Shijiazhuang, China from August 2015 to January 2016 were enrolled in this study. The patients were randomized to receive pitavastatin (4 mg daily) or atorvastatin (20 mg daily)...
2017: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/28804559/microrna-1907-enhances-atherosclerosis-associated-endothelial-cell-apoptosis-by-suppressing-bcl-2
#13
Jin Zhao, Shu-Lin Ou, Wei-You Wang, Chang Yan, Lu-Xiang Chi
Injury and endothelial cell apoptosis are hall marks of atherosclerosis (AS). However, the mechanisms underlying its pathogenesis remain ill-defined. Recent evidence of a role for microRNAs in AS-associated endothelial cell apoptosis encouraged us to address this question. Here, AS was developed in ApoE (-/-) mice supplied with a high-fat diet (HFD), compared to ApoE (-/-) mice supplied with a normal diet (ND). Mouse endothelial cells were isolated from the aortic arch using flow cytometry based on their expression of CD31...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28802933/cognition-in-parkinson-s-disease
#14
Claire O'Callaghan, Simon J G Lewis
Cognitive decline is now recognized as a common nonmotor symptom of Parkinson's disease, and it has been the subject of increasing research in recent decades. Cognitive deficits in Parkinson's disease can be distinguished as dopaminergically mediated executive dysfunction seen in the milder stages vs a global dementia syndrome that can occur with disease progression. The neural basis of these deficits has been explored from the perspective of multimodal imaging techniques to measure the structural, functional, and metabolic correlates of cognitive decline in Parkinson's disease...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28801277/-pioglitazone-ameliorates-atherosclerosis-in-apoe-knockout-mice-through-transforming-growth-factor-%C3%AE-smad-signaling-and-adaptive-t-cell-immunity
#15
Yu-Ling Tian, Li-Jun Wang, Yue Wu, Wei-Ping Zhang, Xiao Liang, Zu-Yi Yuan
OBJECTIVE: To examine whether transforming growth factor-β (TGF-β) pathway and adaptive T cell immunity play roles in the anti-atherosclerotic effects of pioglitazone (PIO) in ApoE(-/-) mice. METHODS: ApoE(-/-) mice with atherosclerosis induced by high-fat feeding were treated daily with PIO (20 mg/kg) or vehicle for 8 weeks. The protein expressions of TGF-β pathway in the atheromatous lesions of the aorta and the percentages of IFN-γ(+) and Foxp3(+) cells in the spleen of the mice were examined with immunohistochemical staining...
August 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28800603/genetic-variants-specific-to-aging-related-verbal-memory-insights-from-gwass-in-a-population-based-cohort
#16
Thalida E Arpawong, Neil Pendleton, Krisztina Mekli, John J McArdle, Margaret Gatz, Chris Armoskus, James A Knowles, Carol A Prescott
Verbal memory is typically studied using immediate recall (IR) and delayed recall (DR) scores, although DR is dependent on IR capability. Separating these components may be useful for deciphering the genetic variation in age-related memory abilities. This study was conducted to (a) construct individual trajectories in IR and independent aspects of delayed recall, or residualized-DR (rDR), across older adulthood; and (b) identify genetic markers that contribute to four estimated phenotypes: IR and rDR levels and changes after age 60...
2017: PloS One
https://www.readbyqxmd.com/read/28800332/cerebral-oxidative-stress-and-microvasculature-defects-in-tnf-%C3%AE-expressing-transgenic-and-porphyromonas-gingivalis-infected-apoe-mice
#17
Farheen Rokad, Ryan Moseley, Rowan S Hardy, Sasanka Chukkapalli, StJohn Crean, Lakshmyya Kesavalu, Sim K Singhrao
The polymicrobial dysbiotic subgingival biofilm microbes associated with periodontal disease appear to contribute to developing pathologies in distal body sites, including the brain. This study examined oxidative stress, in the form of increased protein carbonylation and oxidative protein damage, in the tumor necrosis factor-α (TNF-α) transgenic mouse that models inflammatory TNF-α excess during bacterial infection; and in the apolipoprotein knockout (ApoE-/-) mouse brains, following Porphyromonas gingivalis gingival monoinfection...
August 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28800331/alzheimer-s-disease-biomarkers-interactively-influence-physical-activity-mobility-and-cognition-associations-in%C3%A2-a%C3%A2-non-demented-aging-population
#18
Sherilyn Thibeau, G Peggy McFall, Richard Camicioli, Roger A Dixon
BACKGROUND: Alzheimer's disease (AD) risk-reduction strategies (e.g., increasing physical activity, improving mobility) have garnered increasing attention in the literature. However, the effect of such modifiable factors on the preclinical trajectories of brain and cognitive health may be moderated by non-modifiable biomarkers associated with AD. OBJECTIVE: In a longitudinal sample of non-demented older adults, we examine the independent predictors everyday physical activity (EPA) and mobility on executive function (EF) performance and change...
August 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28799493/association-between-apo-b-levels-in-mothers-and-in-their-pre-school-age-offspring
#19
Valeria Hirschler, Maximiliano Maximiliano Martin, Karen Oestreicher, Claudia Molinari, Laura Boero, Tetzlaff Walter, Fernando Brites
OBJECTIVE: To determine the association between apo B levels in mothers and their pre-school offspring. METHODS: BMI, lipids, and apo B levels were obtained in mothers and their children in November 2015 in Buenos Aires. RESULTS: Eighty-four children (42M) aged 5.3±1.6 years and their mothers aged 33.8±7.2 years were examined. The prevalence of overweight was 39.2% (33) in mothers and 22.6%(19) in children, and the prevalence of obesity was 38...
August 11, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28799191/serum-proteome-in-a-sporadic-amyotrophic-lateral-sclerosis-geographical-cluster
#20
Stefano De Benedetti, Elisabetta Gianazza, Cristina Banfi, Alessandro Marocchi, Christian Lunetta, Silvana Penco, Francesco Bonomi, Stefania Iametti
PURPOSE: This study was meant to characterize the serum proteome in a small geographical cluster of sporadic ALS subjects originating from a restricted geographical area and sharing the same environmental exposure, in a broader context of evaluating the relevance of environmental factors to disease onset, status, and progression. EXPERIMENTAL DESIGN: An Artificial Neural Network based software was used to compare the relative abundance of proteins identified as different (by means of bi-dimensional electrophoresis and mass spectrometry) in the serum proteome of patients and age-matched healthy controls...
August 10, 2017: Proteomics. Clinical Applications
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