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Shok Ping Lim, Nikolaos Ioannou, Alan G Ramsay, David Darling, Joop Gäken, Ghulam J Mufti
MicroRNAs are short endogenous noncoding RNAs that play pivotal roles in a diverse range of cellular processes. The miR-181 family is important in T cell development, proliferation, and activation. In this study, we have identified BRK1 as a potential target of miR-181c using a dual selection functional assay and have showed that miR-181c regulates BRK1 by translational inhibition. Given the importance of miR-181 in T cell function and the potential role of BRK1 in the involvement of WAVE2 complex and actin polymerization in T cells, we therefore investigated the influence of miR-181c-BRK1 axis in T cell function...
May 2018: Journal of Leukocyte Biology
Neel Heerasing, Shok Yin Lee, Sina Alexander, Damian Dowling
AIM: To look at the relationship between eosinophilic oesophagitis (EO) and food bolus impaction in adults. METHODS: We retrospectively analysed medical records of 100 consecutive patients who presented to our hospital with oesophageal food bolus obstruction (FBO) between 2012 and 2014. In this cohort, 96 were adults (64% male), and 4 paediatric patients were excluded from the analysis as our centre did not have paediatric gastroenterologists. Eighty-five adult patients underwent emergency gastroscopy...
November 6, 2015: World Journal of Gastrointestinal Pharmacology and Therapeutics
O V Kurmyshkina, A A Bogdanova, T O Volkova, A N Poltoraka
The capacity for immune surveilance and protection against genetically alien agents is a basic property of multicellular organisms, and increasing significance in realizing this, capacity is assigned to mechanisms of innate immunity. The data accumulated to date show that many components of these mechanisms have a very wide spectrum of biological functions and play essential roles at different stages of ontogeny. An illustrative example is the signal system activated by tumor necrosis factor alpha (TNFα), which is responsible for the inflammation process...
July 2015: Ontogenez
Rajvinder Singh, Shok Y Lee, Nimal Vijay, Prateek Sharma, Noriya Uedo
With the ever-increasing concern regarding morbidity and mortality associated with diseases of the gastrointestinal tract, the importance of an effective and efficient diagnostic tool cannot be overstated. The standard of care currently is an examination using conventional white light endoscopy. This approach may occasionally overlook areas exhibiting a premalignant change. Numerous image-enhanced modalities have been recently introduced. Narrow band imaging (NBI) appears to be the most prominent of these and perhaps the most commonly used...
March 2014: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Puji B S Asih, Ismail E Rozi, Herdiana, Nandha R Pratama, Anggi P N Hidayati, Sylvia S Marantina, Sully Kosasih, Krisin Chand, Suradi Wangsamuda, Faisal A Rusdjy, Maria E Sumiwi, Ali Imran, Titik Yuniarti, Tahi Sianturi, Jamilah Nur, Asnita, Bukhari, Cut Barussanah, Muhammad Yani, Cut Ainun, Kurnia Jamil, Cut Mariam, Simon P Sengkerij, Ferdinand J Laihad, William Hawley, Din Syafruddin
BACKGROUND: Sabang Municipality, in Aceh Province, Indonesia, plans to initiate a malaria elimination programme in 2013. A baseline survey of the distribution of malaria in the municipality was conducted to lay the foundations for an evidence-based programme and to assess the island's readiness to begin the elimination process. METHODS: The entire population of the municipality was screened for malaria infection and G6PD deficiency. Specimens collected included blood slides, blots and tubes for selected households...
2012: Malaria Journal
Dan Zhao, Feifei Li, Aiyun Zhang
A new type of naphthalene-1,8-dicarb-oxy-lic anhydride, C(12)H(6)O(3), was synthesized hydro-thermally. Unlike the two previously reported polymorphs, which crystallize in the ortho-rhom-bic space groups P2(1)2(1)2(1) [Shok et al. (1971). Kristallografiya, 16, 500-502; Grigor'eva & Chetkina (1975). Kristallografiya, 20, 1289-1290] and Pbca [Shok & Gol'der (1970). Zh. Strukt. Khim.11, 939-940], this present structure crystallizes in the monoclinic space group P2(1)/c. In this structure, the planar [total puckering amplitude Q = 0...
2010: Acta Crystallographica. Section E, Structure Reports Online
Salem Abdessalem, Sajed Mjadlah, Hichem Mahjoub, Sami Mourali, Rachid Mechemeche
BACKGROUND: Percutaneous coronary intervention (PCI) has been proven to be the gold standard of reperfusion therapies in acute ST-elevation myocardial infarction (STEMI) in the western world. Highly trained teams and good logistical management of cathlabs may be limiting factors in developing countries and data about outcomes following PCI in such areas is scarce. AIM: The objectives of this study were to describe the procedural and clinical outcomes of patients undergoing PCI for STEMI at a university hospital in Tunisia and make a comparison with outcomes from the West...
November 2009: La Tunisie Médicale
Kang Sim, Yiong Huak Chan, Phui Nah Chong, Hong Choon Chua, Shok Wen Soon
OBJECTIVE: The psychological and coping responses of the noninfected community towards infectious disease outbreaks are relatively understudied. This cross-sectional study sought to determine the prevalence of severe acute respiratory syndrome (SARS)-related psychiatric and posttraumatic morbidities and associated coping styles within the general population visiting community health care services. METHODS: It was conducted on individuals attending community polyclinics in Singapore within the first week of July 2003, 16 weeks after the first national outbreak of SARS...
February 2010: Journal of Psychosomatic Research
Constantin von See, Alexander Stuehmer, Nils-Claudius Gellrich, Katrin S Blum, Kai-Hendrik Bormann, Martin Rücker
BACKGROUND: There are considerable differences in the shape and composition of military and civilian projectiles. MATERIALS AND METHODS: Five different projectiles with the same kinetic energy were fired into the heads of freshly sacrificed pigs (n=30) through the submental region in the occipital direction. Computed tomography (CT) and 3D face scans of the animal skulls were obtained before and after firing. The image data sets were fused and provided the basis for a quantitative analysis of destruction patterns...
July 2009: Military Medicine
Leslie Lewis, K M Sanoj, Ganesh Poojari, Sowmini P Kamath
Splenic hematoma is an unusual event in newborn babies. The present study report a two day old infant who presented to us in shok with severe pallor and abdominal distension. Initially ultrasonography of evaluation by ultrasound (US) revealed a left adrenal hemorrhage but was subsequently confirmed to be a subcapsular splenic hematoma by computed tomography (CT) scan of the abdomen. This article highlights the utility of CT scan in diagnosis although review of literature shows ultrasonography to be primary screening investigative modality for abdominal visceral bleeds in the neonatal period...
September 2008: Indian Journal of Pediatrics
No abstract text is available yet for this article.
1948: A Pediatria; Revista Mensal de Clinica, Patologia e Higiene Infantil
H Caixia, Y Xinjian, L Rong, T Zhangcheng, S Yungang, X Chumhe
The effect of glycinebetaine in selectively stabilizing the PSII extrinsic polypeptides was studied with PSII particles treated with different methods. It wan shown that glycinebetaine markedly stabilized the PSII extrinsic polypeptides when the partictes were treated with 0.8 mol/L Tris (pH8.0) or high concentrations of NaCI. The stabilizing effect was less pronounced when the PSII particles were treated by heat shok or trichlorocetate (TCA). The capability of halogenated acetates to release extrinsic polypeptides in PSII particles was found to follow the order of decreasing molecular hydrophobicities: trichloroacetate (TCA) > dichloroacetate (DCA) > monoiodoacetate (MIA) > monobromoacetate (MBA) > monochloroacetate (MCA)...
June 1998: Science in China. Series C, Life Sciences
Tomoyuki Hamamoto, Keiji Suzuki, Hitoshi Sasaki, Masataka Ichikawa, Seiji Kodama, Masami Watanabe
Methods to predict the responsiveness of a particular tumor to a particular anticancer drug are desirable not only for chemotherapy but also for chemoradiotherapy. Here, we examined the effects of viral or activated oncogenes on sensitivity to anticancer drugs by using SHOK (Syrian hamster Osaka-Kanazawa) cells and their transfectants. The IC50 of each transfectant was compared with that of the pSV2Neo transfected control. Cells transfected with the c-myc, v-mos, or v-fgr gene increased their sensitivity to bleomycin, while those transfected with the H-ras gene developed resistance...
June 2005: Journal of Radiation Research
Abdulkarim Agunu, E M Abdurahman, M Shok, Sadiq A Yusuf
The analgesic activity of the methanolic extracts of the roots and leaves of Calliandra portoricensis was investigated in mice and rats using acetic acid-induced writhing and formalin tests. The extracts given orally at the doses of 200, 400, 600 mg/kg showed a dose-dependent activity in the tests used.
July 2005: Fitoterapia
Kang Sim, Phui Nah Chong, Yiong Huak Chan, Winnie Shok Wen Soon
BACKGROUND: Severe acute respiratory syndrome (SARS) is a major new infectious disease of this century that is unique in its high morbidity and concentration in health care settings. We aimed to determine the level of psychological impact and coping styles among the medical staff in a primary health care setting. METHOD: Using a structured questionnaire, we conducted a cross-sectional survey of the doctors and nurses working within a public, primary health care setting in mid-July 2003...
August 2004: Journal of Clinical Psychiatry
O Kunle, J Okogun, E Egamana, E Emojevwe, M Shok
This study examines the antimicrobial activity of the hexane, dichloromethane and methanol extracts of Lippia multiflora and carvacrol isolated from the hexane extract. The result shows the hexane extract to be the most active, while the methanol extract exhibited no antimicrobial activity. The isolated carvacrol from the hexane fraction showed tremendous antimicrobial activity. These results confirm the traditional uses of Lippia multiflora in the treatment of disease conditions due to microbes.
January 2003: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
M S Abubakar, A J Nok, E M Abdurahman, A K Haruna, M Shok
Two phospholipase enzymes NN1 and NN2 were purified from the venom of Naja nigricolis nigricolis Reinhardt to apparent homogeneity. NN1 was purified by a two-step anion-exchange chromatography on DEAE-cellulose column while NN2 was purified by a combination of anion-exchange chromatography and gel filtration on Sephadex G-150. The enzyme NN1 moved homogenously on acrylamide gel as a monomer with a molecular weight of 65 kDa while NN2 was a dimer of 71 kDa. Both enzymes were clearly separated. Both enzymes hydrolyzed L-alpha-phosphatidyl choline with activities of 345...
2003: Journal of Biochemical and Molecular Toxicology
L B Davidovic, D S Spasic, S I Lotina, D M Kostic, I S Cinara, S D Svetkovic, P M Djordic
INTRODUCTION: The aorto-enteric fistula (AEF) is a direct communication between aorta and intestinal lumen. There are primary and secondary forms. Primary AEFs are usually due to erosion of an aortic aneurysm (AAA) into the intestine, while secondary forms are caused by reconstructive procedures on the abdominal aorta. The incidence of primary AEF ranges from 0.1 to 0.8%, and secondary from 0.4% to 2.4% [2-4]. The mortality rate after surgical treatment of secondary AEFs is from 14% to 70% [5]...
July 2001: Srpski Arhiv za Celokupno Lekarstvo
Y Kinashi, M Akaboshi, S Masunaga, K Ono, M Watanabe
SHOK (Syrian hamster Osaka-Kanazawa) cells were transfected with activated oncogenes (v-mos, c-myc, N-ras, H-ras, K-ras). These oncogene-transfected cells were treated with 195mPt-cis-diaminedichloroplatinum (II) (CDDP). Clonogenic cell survival assay showed that oncogene-transfected cells exhibited 1.3-4.8 fold (v-mos; 2.4, c-myc; 3.6, N-ras; 1.3, H-ras; 4.8, K-ras; 2.3) increased resistance to cisplatin compared with the parental SHOK cells. The distribution of DNA, RNA, and protein fractions of treated cells was determined using the method of Schneider...
July 1998: Radiation Medicine
N K Dzeranov, A G Pugachev, K V Voronin, V A Ukolov, A V Lykov, I N Volkov
The method of extracorporeal shock-wave lithotripsy (ESWL) is widely practiced in urology as effective and less traumatic. Utilization of x-ray and video control during ESWL sessions raises the problem of radiation protection of the patient and medical personnel as well as registration of the exposure dose for estimation of further permissible doses. The examination covered 48 patients of different age suffering from urolithiasis. All of them received ESWL treatment using units URAT (Russia) and LITOSTAR (Germany) having x-ray positioning...
January 1998: Urologii︠a︡ i Nefrologii︠a︡
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