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Sandy Huey-Jen Hsu, Duan-Rung Chen, Yawen Cheng, Ta-Chen Su
OBJECTIVES: This study aims to investigate whether psychosocial work-related hazards, measured by workplace justice and employment insecurity, are associated with depression and suboptimal health status in Taiwan's executive-level employees. METHODS: There were 365 executives who have received a series of cardiovascular health examinations, blood sampling, and self-reported questionnaires, which included the psychosocial work-related hazards and the CES-D scale...
July 2016: Journal of Occupational and Environmental Medicine
Sergio Montserrat-de la Paz, Maria C Naranjo, Sergio Lopez, Rocio Abia, Francisco J G Muriana, Beatriz Bermudez
Metabolic syndrome (MetS) is associated with obesity, dyslipemia, type 2 diabetes and chronic low-grade inflammation. The aim of this study was to determine the role of high-fat low-cholesterol diets (HFLCDs) rich in SFAs (HFLCD-SFAs), MUFAs (HFLCD-MUFAs) or MUFAs plus omega-3 long-chain PUFAs (HFLCD-PUFAs) on polarisation and inflammatory potential in bone marrow-derived macrophages (BMDMs) from niacin (NA)-treated Lep(ob/ob)LDLR(-/-) mice. Animals fed with HFLCD-SFAs had increased weight and serum triglycerides, and their BMDMs accumulated triglycerides over the animals fed with HFLCD-MUFAs or -PUFAs...
May 18, 2016: Food & Function
E Blanco-Martin, S Del Mazo-Sanchez, A Molano-Salazar, R Bereincua-Gandarias, V Llorens-Abando, M Fernandez-Martinez
INTRODUCTION: Thalamic vascular lesions as strategic strokes can cause amnesia, executive dysfunctions or dysphasia and behavioral or psychological symptoms causing vascular dementia. CASE REPORT: A 58 years-old woman with hypertension and dyslipemia, who after a left thalamic hemorrhage with good radiological evolution, presents a severe amnesic syndrome as well as other subtle changes in orientation and in language, difficulties in managing money and depressive symptoms requiring anxiolytic and antidepressive treatment...
May 1, 2016: Revista de Neurologia
Nuria Lainez, Jesús García-Donas, Emilio Esteban, Javier Puente, M Isabel Sáez, Enrique Gallardo, Álvaro Pinto-Marín, Sergio Vázquez-Estévez, Luis León, Icíar García-Carbonero, Cristina Suárez-Rodríguez, Carmen Molins, Miguel A Climent-Duran, Martín Lázaro-Quintela, Aranzazu González Del Alba, María José Méndez-Vidal, Isabel Chirivella, Francisco J Afonso, Marta López-Brea, Nuria Sala-González, Montserrat Domenech, Laura Basterretxea, Carmen Santander-Lobera, Irene Gil-Arnáiz, Ovidio Fernández, Cristina Caballero-Díaz, Begoña Mellado, David Marrupe, José García-Sánchez, Ricardo Sánchez-Escribano, Eva Fernández Parra, José C Villa Guzmán, Esther Martínez-Ortega, María Belén González, Marina Morán, Beatriz Suarez-Paniagua, María J Lecumberri, Daniel Castellano
BACKGROUND: The impact of such recommendations after their implementation of guidelines has not usually been evaluated. Herein, we assessed the impact and compliance with the Spanish Oncology Genitourinary Group (SOGUG) Guidelines for toxicity management of targeted therapies in metastatic renal cell carcinoma (mRCC) in daily clinical practice. METHODS: Data on 407 mRCC patients who initiated first-line targeted therapy during the year before and the year after publication and implementation of the SOGUG guideline program were available from 34 Spanish Hospitals...
2016: BMC Cancer
Pedro E Colla-Machado, Ariel A Luzzi, Natalia R Balian, Santiago G Pigretti, M Cristina Zurrú-Ganen, Edgardo Cristiano, Stella M Valiensi
INTRODUCTION: The obstructive sleep apnea syndrome (OSA) confers increased risk of cardiovascular disease, given its association with other vascular risk factors. Both OSA and other vascular risk factors are associated with silent brain lesions. AIM: To assess the prevalence of silent brain lesions in patients with OSA. PATIENTS AND METHODS: We retrospectively evaluated a cohort of 137 patients with OSA. The mean age was 65 ± 12 years; 45% were women...
February 1, 2016: Revista de Neurologia
T Haddad, D Hakem, A Berrah
INTRODUCTION: The pregnancies in systemic erythematous lupus (SLE) disease is a situation of high risk and involve both the mother and the fetus. The prematurity and the miscarriage are there more frequent, with increase risks of eclampsia, acute hypertension, HELP syndrome and of worsening renal disease. So the morbimortality is multiplied particularly when a anti-phospholipid syndrome 'APLS' is associated. The pregnancy remains however authorized when the SLE is in remission for more than 6 months with a validated treatment and successful means of monitoring...
July 2012: Pregnancy Hypertension
Anna Rull, Maria Martínez-Bujidos, Montserrat Pérez-Cuellar, Antonio Pérez, Jordi Ordóñez-Llanos, José Luis Sánchez-Quesada
OBJECTIVE: Clusterin/apolipoprotein J (apoJ) circulates in blood in part associated to lipoproteins or in unbound form. When bound to HDL, apoJ is antiatherogenic by inhibiting endothelial cell apoptosis; thus, any factor modifying apoJ association to HDL would decrease its antiatherogenic function. However, the exact distribution of apoJ in each lipoprotein fraction, or in lipoprotein-non bound form has not been specifically investigated either in normolipemia or in dyslipemia. METHODS: Basic lipid profile and apoJ concentration were determined in sera from 70 subjects, including a wide range of cholesterol and triglyceride concentrations...
August 2015: Atherosclerosis
Julio Argonz, Eleonora Puentes, Patricia Matos, Joaquín Argonz, Mónica Morzilli, Horacio Vázquez, María Carolina Bolino
BACKGROUND: Obesity is associated with systemic co-morbi- dities. Conservative management has a low rate ofsuccess in the short and long term. Therefore, novel endoscopic strate- gies have emerged as alternative therapies to bariatric sur- gery. The intragastric balloon (IGB) is a temporary, effective and safe endoscopic treatment for weight loss. Objectives. 1. To describe changes in body mass index (BMI) in patients who completed treatment with IGB. 2. To describe metabo- lic co-morbidities and psychological features at admission...
March 2015: Acta Gastroenterologica Latinoamericana
Andreu Prados-Bo, Sonia Gómez-Martínez, Esther Nova, Ascensión Marcos
Obesity is a major public health issue as it is related to several chronic disorders, including type-2 diabetes, high blood pressure, dyslipemia, cardiovascular diseases and cancer, among others. Novel research shows that the gut microbiota is involved in obesity and metabolic disorders, revealing that obese animal and human subjects have alterations in the composition of the gut microbiota compared to their lean counterparts. Moreover, it has been observed in germ-free mice that transplantation of the microbiota of either obese or lean mice influences body weight, suggesting that the gut ecosystem is a relevant target for weight management...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Sophie Blat, Sophie Vincent, Luz Lefeuvre, Sophie Lemoine-Morel, Charles-Henri Malbert, Lisa Pichon, Takashi Mikogami, Arlette Gratas-Delamarche
OBJECTIVE: The pandemic of obesity in Western countries is mainly due to the high-fat, high-energy diet prevailing there. Obesity-associated metabolic disorders are the consequence of fat mass increase leading to altered adipokine secretion, hyperlipemia, oxidant stress, low-grade inflammation, and eventually glucose intolerance. Yet not all people consuming a Western diet become obese, and the question is raised whether these people are also at risk of developing metabolic disorders...
February 2015: Obesity
Emilio Ortega, Antonio J Amor, Gemma Rojo-Martínez, Conxa Castell, Marga Giménez, Ignacio Conget
BACKGROUND AND OBJECTIVE: To describe the prevalence of cardiovascular disease (CVD) in type 1 diabetes (T1DM) and to compare it with that observed in type 2 diabetes (T2DM) and normal population in Spain. PATIENTS AND METHODS: Cross-sectional study (18-70 years-old). Information on CVD was available from a nurse-administered questionnaire ( Study, NORMAL=3,430, T2DM=312) and from a physician reporting form (T1DM=1,382). Differences in the crude and adjusted prevalence of coronary heart (CHD), cerebrovascular (CNSD), peripheral vascular (PVD) and overall CV (CVD) disease were investigated between T1DM vs...
September 21, 2015: Medicina Clínica
Jesús Millán Núñez-Cortés, Vicente Lahera Juliá, Manuel Vázquez Carrera, Juan Pedro-Botet
No abstract text is available yet for this article.
January 2015: Clínica e Investigación en Arteriosclerosis
Valerie Samouillan, Elena Revuelta-López, Jany Dandurand, Laura Nasarre, Lina Badimon, Colette Lacabanne, Vicenta Llorente-Cortés
Dyslipemia has a direct impact on cardiac remodeling by altering extracellular matrix (ECM) components. One of the main ECM components is elastin, a proteic three-dimensional network that can be efficiently degraded by cysteine proteases or cathepsins. Dyslipemic status in insulin resistance and combined hyperlipoproteinemia diseases include raised levels of very low density lipoproteins (VLDL), triglyceride (TG)-cholesteryl ester (CE)-rich lipoproteins. Enhanced VLDL concentration promotes cardiomyocyte intracellular cholesteryl ester (CE) accumulation in a LRP1-dependent manner...
October 2014: International Journal of Biochemistry & Cell Biology
Arnaud De Roover, Laurent Kohnen, Jenny Deflines, Barbara Lembo, Vinciane Goessens, Nicolas Paquot, Severine Lauwick, Abdourhamane Kaba, Jean Joris, Michel Meurisse
BACKGROUND: The Magenstrasse and Mill (M&M) procedure is a vertical gastroplasty creating a tubular pouch extending from the cardia to the antrum. This "incomplete sleeve" avoids gastric resection or band placement. In this paper, we report our experience of the laparoscopic approach of the technique in a selected obese population excluding prominent grazer and/or sweet eaters. MATERIAL AND METHODS: One hundred patients (39 males, 61 females) underwent the procedure in a prospective trial...
February 2015: Obesity Surgery
María Merino Viveros, Belén Vega Piñero, Fernando Gil Ares, M Guadalupe Guijarro de Armas, July Maribel Montaño Martinez, Cristina Navea Aguilera
Patients with cholestatic diseases can present secondary hypercholesterolemia, as a result of the accumulation of lipoprotein X (Lp-X); an abnormal LDL form, considered as the biochemical parameter more sensitive and specific for the diagnosis of cholestasis intra or extrahepatic cholestasis. The aim of this clinical communication is to illustrate this association. A 54-year-old male with severe cholestatic liver disease which in turn presents a progressive total cholesterol rise and LDL with presence of lipoprotein X...
2014: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Ignacio Sola Galarza, Borja López López, Carlos Llorente Abarca
We define dyslipemia as the abnormally elevated presence of lipids in the blood. The main ones are hypercholesterolemia (cholesterol over 240 mg/dl), hypertrigliceridemia (triglicerides level over 200 mg/dl) and hipo-alphalipoproteinemia (High density lipoproteins,also called HDL Cholesterol, below 40 mg/dl). The presence of excessive lipids contributes to arteriosclerosis and they are an independent cardiovascular risk factor. It may be primary, if they have genetic origin and they are not associated with other diseases, but in most cases they are secondary to other pathological entities such as diabetes, hypothyroidism, obesity and metabolic syndrome (MS)...
September 2013: Archivos Españoles de Urología
Mario Alvarez-Maestro, Francisco Javier Sánchez Gómez, Luis San José Manso, Emilio Ríos González, Luis Martínez-Piñeiro
OBJECTIVES: Testosterone deficit syndrome (TDS)is a clinical and biochemical entity characterized by low testosterone levels and androgenic deprivation clinic, which can cause a decrease in the quality of life. However, today there are doubts about its diagnosis and therapeutic management. METHODS: Bibliographic review using the MedLine database and detailed presentation of one clinical case. RESULTS: Testosterone deficit syndrome is associated with metabolic syndrome (visceral obesity, arterial hypertension, diabetes mellitus and dyslipemia)...
September 2013: Archivos Españoles de Urología
Jose Maria Martinez-Jabaloyas
The progressive aging of the population and the wish to keep a good quality of life in advanced ages makes testosterone deficit syndrome associated with aging a health issue of increasing relevance. It is a proved fact there is a decrease of androgen levels associated with aging. Nevertheless, there are some difficulties to establish what is the actual prevalence, since there are some ambiguities about which clinical and biochemical parameters allow us to state a correct clinical diagnosis. The figures on prevalence are variable, specially taking into consideration the different age ranges found in the studies, but we could say there would be a global prevalence of around 6% to 12% of symptomatic hypogonadism in the age range between 30/40 and 70 years, with a progressive increase with age There is a series of factors that may favor androgen deficit increasing the prevalence in different population groups...
September 2013: Archivos Españoles de Urología
Patricia Echeverría, Anna Bonjoch, José Moltó, Antoni Jou, Jordi Puig, Arelly Ornelas, Nuria Pérez-Álvarez, Bonaventura Clotet, Eugenia Negredo
BACKGROUND: Chronic HIV infection leads to premature atherosclerosis. Arterial stiffness is considered a subclinical marker of cardiovascular disease. METHODS: Pulse wave velocity (PWV) was determined in 254 individuals (174 HIV-infected patients and 80 healthy controls, 2:1 matched by age and gender) to compare the prevalence of arterial stiffness and to identify associated factors. PWV was determined using noninvasive automated device (Complior). Factors associated with impaired PWV were assessed among cardiovascular risk factors, HIV infection parameters, and laboratory data...
January 1, 2014: Journal of Acquired Immune Deficiency Syndromes: JAIDS
José María Mostaza, Carlos Lahoz
Reduction in the risk of cardiovascular complications through modification of lipids is currently focused on lowering low density lipoproteins-cholesterol, with statins being the preferred drugs. New agents, under research, such as antibodies neutralizing PCSK9, will have a special place for the management of patients with intolerance to statins of severe dyslipemias. Drugs used to modify the concentration of high density lipoproteins-cholesterol and triglycerides have not been accompanied by the expected reductions in the rate of cardiovascular complications...
April 7, 2014: Medicina Clínica
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