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Corticotropin releasing (factor OR hormone)

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https://www.readbyqxmd.com/read/29043393/characterization-of-a-set-of-abdominal-neuroendocrine-cells-that-regulate-stress-physiology-using-colocalized-diuretic-peptides-in-drosophila
#1
Meet Zandawala, Richard Marley, Shireen A Davies, Dick R Nässel
Multiple neuropeptides are known to regulate water and ion balance in Drosophila melanogaster. Several of these peptides also have other functions in physiology and behavior. Examples are corticotropin-releasing factor-like diuretic hormone (diuretic hormone 44; DH44) and leucokinin (LK), both of which induce fluid secretion by Malpighian tubules (MTs), but also regulate stress responses, feeding, circadian activity and other behaviors. Here, we investigated the functional relations between the LK and DH44 signaling systems...
October 17, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29042907/effects-of-puerarin-combined-with-conventional-therapy-on-ischemic-stroke
#2
Min Yuan, Guijiang Liu, Xiuqi Zheng, Pei Li, Jinghua Liu, Sujie Wang, Yibin Cao
This study evaluated the use of conventional therapy combined with puerarin on ischemic stroke. Eighty patients with ischemic stroke admitted to Tangshan Gongren Hospital from March 2014 to September 2015 were randomly divided into two groups. The control group was treated with conventional therapy. The observation group was treated with an additional puerarin injection of 400 mg/day. The patients in both groups were examined for clinical neurological signs and symptoms. The levels of biochemical markers as well as changes in hemorheology were measured after the intervention and compared among the groups...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29039159/cortisol-and-migraine-a-systematic-literature-review
#3
Giuseppe Lippi, Camilla Mattiuzzi
Migraine is a highly prevalent and disabling disorder. Because stress appears to be a prominent trigger of this condition and cortisol is a well-established stress hormone, we performed a search on Medline, Scopus, and Web of Science to identify clinical studies that assessed cortisol levels in migraineurs. Four cross-section studies, one observational study, and three both cross-sectional and observational studies were finally included in our analysis. The heterogeneity was modest for the sample size (49.8%) but was remarkably high for a sample matrix (66...
July 2017: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/29037972/sex-differences-in-circuits-activated-by-corticotropin-releasing-factor-in-rats
#4
Madeleine Salvatore, Kimberly Wiersielis, Sandra Luz, David Waxler, Seema Bhatnagar, Debra A Bangasser
Women are more likely than men to suffer from psychiatric disorders characterized by corticotropin releasing factor (CRF) hypersecretion, suggesting sex differences in CRF sensitivity. In rodents, sex differences in the sensitivity of specific brain regions to CRF have been identified. However, regions do not work in isolation, but rather form circuits to coordinate distinct responses to stress. Here we examined whether CRF activates different circuits in male and female rats. Following central administration of CRF or artificial cerebrospinal fluid (aCSF), neuronal activation in stress-related areas was assessed using cFOS...
October 13, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29033832/cyclotides-isolated-from-an-ipecac-root-extract-antagonize-the-corticotropin-releasing-factor-type-1-receptor
#5
Mohsen Fahradpour, Peter Keov, Carlotta Tognola, Estela Perez-Santamarina, Peter J McCormick, Alireza Ghassempour, Christian W Gruber
Cyclotides are plant derived, cystine-knot stabilized peptides characterized by their natural abundance, sequence variability and structural plasticity. They are abundantly expressed in Rubiaceae, Psychotrieae in particular. Previously the cyclotide kalata B7 was identified to modulate the human oxytocin and vasopressin G protein-coupled receptors (GPCRs), providing molecular validation of the plants' uterotonic properties and further establishing cyclotides as valuable source for GPCR ligand design. In this study we screened a cyclotide extract derived from the root powder of the South American medicinal plant ipecac (Carapichea ipecacuanha) for its GPCR modulating activity of the corticotropin-releasing factor type 1 receptor (CRF1R)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29033027/anhedonia-following-early-life-adversity-involves-aberrant-interaction-of-reward-and-anxiety-circuits-and-is-reversed-by-partial-silencing-of-amygdala-corticotropin-releasing-hormone-gene
#6
Jessica L Bolton, Jenny Molet, Limor Regev, Yuncai Chen, Neggy Rismanchi, Elizabeth Haddad, Derek Z Yang, Andre Obenaus, Tallie Z Baram
BACKGROUND: Anhedonia, the diminished ability to experience pleasure, is an important dimensional entity linked to depression, schizophrenia, and other emotional disorders, but its origins and mechanisms are poorly understood. We have previously identified anhedonia, manifest as decreased sucrose preference and social play, in adolescent male rats that experienced chronic early-life adversity/stress (CES). Here we probed the molecular, cellular, and circuit processes underlying CES-induced anhedonia and tested them mechanistically...
September 7, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29032090/hypothalamic-pituitary-adrenal-hpa-axis-functioning-as-predictor-of-antidepressant-response-meta-analysis
#7
REVIEW
Susanne Fischer, Christine Macare, Anthony J Cleare
OBJECTIVE: Although antidepressants are effective, around 50% of depressed patients are non-responsive. At the same time, some patients show alterations in the hypothalamic-pituitary-adrenal (HPA) axis. Due to interactions with central monoaminergic systems, these may profit less from antidepressants. METHOD: To determine whether non-responders and responders differed in pre-treatment HPA axis functioning, the Cochrane Library, EMBASE, MEDLINE, and PsycINFO were searched...
October 12, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29025388/editorial-corticotropin-releasing-factor-crf-and-its-receptors-from-structure-to-function-in-health-and-disease-part-i
#8
EDITORIAL
George Liapakis
No abstract text is available yet for this article.
2017: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/28993972/the-effect-of-acute-and-repeated-stress-on-crh-r1-and-crh-r2-mrna-expression-in-pituitaries-of-wild-type-and-crh-knock-out-mice
#9
Vera Klenerova, Richard Kvetnansky, Sixtus Hynie
The activation of the HPA axis is the endocrine measure of stress responsiveness that is initiated by corticotropin-releasing hormone (CRH). CRH exerts its effects via CRHR1 and CRH-R2 receptors coupled to the cAMP signaling system and this process involves transcription factor cAMP-responsive element-binding protein (CREB).This study investigated the role of CRH and the possible involvement of CREB in gene regulation of CRH receptor, under basal conditions and after stress application in the pituitary. We used wild type (wt +/+) controls and CRH knock-out (CRH-KO -/-) male mice...
October 9, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28992676/intravenous-corticotropin-releasing-hormone-administration-increases-esophageal-electrical-sensitivity-in-healthy-individuals
#10
Takahisa Yamasaki, Toshihiko Tomita, Mayu Takimoto, Takashi Kondo, Katsuyuki Tozawa, Yoshio Ohda, Tadayuki Oshima, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
Background/Aims: When a person is experiencing stress, corticotropin-releasing hormone (CRH) can modulate gut physiologies, such as visceral sensation or gastrointestinal motility, and its intravenous administration mimics stress-induced physiological changes. However, the influence of CRH on the esophagus is yet unknown. Accordingly, we investigated whether intravenous CRH administration increases esophageal sensitivity to electrical stimulation in healthy Japanese subjects. Methods: Twenty healthy subjects were recruited...
October 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28988966/murine-social-stress-results-in-long-lasting-voiding-dysfunction
#11
Stephan Butler, Sandra Luz, Kile McFadden, Joanna Fesi, Christopher Long, Lynn Spruce, Steven Seeholzer, Douglas Canning, Rita Valentino, Stephen Zderic
Repeated exposure to social stress shifts the voiding phenotype in male mice leading to bladder wall remodeling and is associated with increased expression of the stress neuropeptide, corticotropin-releasing factor (CRF) in Barrington's nucleus neurons. In these studies, we set out to determine if the voiding phenotype could recover upon removal from the stressor. Male mice were exposed for 1h daily to an aggressor and the voiding phenotype was assessed at one month followed by randomization to three groups...
October 6, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28986303/corticotropin-releasing-hormone-can-selectively-stimulate-glucose-uptake-in-corticotropinoma-via-glucose-transporter-1
#12
Jie Lu, Blake K Montgomery, Grégoire P Chatain, Alejandro Bugarini, Qi Zhang, Xiang Wang, Nancy A Edwards, Abhik Ray-Chaudhury, Marsha J Merrill, Russell R Lonser, Prashant Chittiboina
BACKGROUND: Pre-operative detection of corticotropin (ACTH) secreting microadenomas causing Cushing's disease (CD) improves surgical outcomes. Current best magnetic resonance imaging fails to detect up to 40% of these microadenomas. (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) is specific, but not sensitive in detecting corticotropinomas. Theoretically, secretagogue stimulation with corticotropin releasing hormone (CRH) could improve detection of adenomas with (18)F-FDG PET...
October 3, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28982596/subsequent-maternal-separation-exacerbates-neurobehavioral-abnormalities-in-rats-neonatally-exposed-to-sevoflurane-anesthesia
#13
Jiaojiao Yang, Lingsha Ju, Min Jia, Hui Zhang, Xiaoru Sun, Muhuo Ji, Jianjun Yang, Anatoly E Martynyuk
Several recent studies suggest that in the human population, a routine, short anesthetic in otherwise healthy infants is void of neurodevelopmental insult. On the other hand, many human retrospective epidemiological studies report evidence of cognitive abnormalities in children after testing those who had different anesthesia-requiring procedures in early childhood. We tested in a rat model whether post-anesthesia stressful environmental factors can contribute to developmental abnormalities that were initiated by a relatively short exposure to sevoflurane, the most widely used anesthetic in pediatric anesthesia, whose polyvalent actions include enhancement of gamma-aminobutyric acid type A receptor (GABAAR) activity...
October 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28979159/sound-stress-induced-altered-nociceptive-behaviors-are-associated-with-increased-spinal-crfr2-gene-expression-in-a-rat-model-of-burn-injury
#14
Natasha M Sosanya, Alex V Trevino, Roger L Chavez, Robert J Christy, Bopaiah P Cheppudira
Sound stress (SS) elicits behavioral changes, including pain behaviors. However, the neuronal mechanisms underlying SS-induced pain behaviors remain to be explored. The current study examined the effects of SS on nociceptive behaviors and changes in expression of the spinal corticotropin-releasing factor (CRF) system in male Sprague Dawley rats with and without thermal pain. We also studied the effects of SS on plasma corticosterone and fecal output. Rats were exposed to 3 days of SS protocol (n = 12/group)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28966574/learning-and-crf-induced-indecision-during-escape-and-submission-in-rainbow-trout-during-socially-aggressive-interactions-in-the-stress-alternatives-model
#15
Tangi R Summers, Torrie L Summers, Russ E Carpenter, Justin P Smith, Samuel L Young, Brandon Meyerink, T Zachary Orr, David H Arendt, Cliff H Summers
Socially stressful environments induce a phenotypic dichotomy of coping measures for populations in response to a dominant aggressor and given a route of egress. This submission- (Stay) or escape-oriented (Escape) dichotomy represents individual decision-making under the stressful influence of hostile social environments. We utilized the Stress-Alternatives Model (SAM) to explore behavioral factors which might predict behavioral phenotype in rainbow trout. The SAM is a compartmentalized tank, with smaller and larger trout separated by an opaque divider until social interaction, and another divider occluding a safety zone, accessible by way of an escape route only large enough for the smaller fish...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28963545/altered-brain-and-gut-responses-to-corticotropin-releasing-hormone-crh-in-patients-with-irritable-bowel-syndrome
#16
Michiko Kano, Tomohiko Muratsubaki, Lukas Van Oudenhove, Joe Morishita, Makoto Yoshizawa, Keiji Kohno, Mao Yagihashi, Yukari Tanaka, Shunji Mugikura, Patrick Dupont, Huynh Giao Ly, Kei Takase, Motoyori Kanazawa, Shin Fukudo
Stress is a known trigger of irritable bowel syndrome (IBS) and exacerbates its gastrointestinal symptoms. However, underlying the physiological mechanism remains unknown. Here, we investigated hypothalamic-pituitary-adrenal (HPA) axis, colonic motility, and autonomic responses to corticotropin-releasing hormone (CRH) administration as well as brain activity alterations in IBS. The study included 28 IBS patients and 34 age and sex-matched healthy control subjects. IBS patients demonstrated greater adrenocorticotropic hormone (ACTH) responses to CRH than control subjects...
September 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28963067/nucb2-nesfatin-1-expression-and-functions-in-the-regulation-of-emotion-and-stress
#17
REVIEW
Yanyan Wei, Jiangbo Li, Huiling Wang, Gaohua Wang
Nesfatin-1, a food-intake inhibiting factor processed from nucleobindin 2 (NUCB2), was originally identified by the Oh-I research group. The initial functional studies on NUCB2/nesfatin-1 were mainly focused on its properties of appetite regulation. As is well known, emotional state has an interactional relationship with food intake, and difficulties in regulating emotion and stress have a great influence on appetite and body weight. Some anorexigenic or orexigenic neurotransmitters also play a role in the adjustment of emotion and stress responses in addition to their actions on the homeostatic regulation of food intake, including neuropeptide Y (NPY), melanocyte stimulating hormone (MSH), corticotropin-releasing factor (CRF), and ghrelin...
September 26, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28958860/high-environmental-ammonia-exposure-has-developmental-stage-specific-and-long-term-consequences-on-the-cortisol-stress-response-in-zebrafish
#18
Tegan A Williams, Luke A Bonham, Nicholas J Bernier
The capacity for early life environmental stressors to induce programming effects on the endocrine stress response in fish is largely unknown. In this study we determined the effects of high environmental ammonia (HEA) exposure on the stress response in larval zebrafish, assessed the tolerance of embryonic and larval stages to HEA, and evaluated whether early life HEA exposure has long-term consequences on the cortisol response to a novel stressor. Exposure to 500-2000μM NH4Cl for 16h did not affect the gene expression of corticotropin-releasing factor (CRF) system components in 1day post-fertilization (dpf) embryos, but differentially increased crfa, crfb and CRF binding protein (crfbp) expression and stimulated both dose- and time-dependent increases in the whole body cortisol of 5dpf larvae...
December 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28951706/does-the-corticotropin-releasing-hormone-system-play-a-role-in-the-pathogenesis-of-lichen-planus
#19
Bengu Cevirgen Cemil, Demet Yilmazer, Hatice Atas, Fatma Pelin Cengiz, Filiz Canpolat, Murat Alper, Muzeyyen Gonul
INTRODUCTION: Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis. AIM: To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP. MATERIAL AND METHODS: Thirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded...
August 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28948742/-effects-of-baldrinal-of-valeriana-jatamansi-on-expression-of-crf-tph1-mrna-and-5-ht-in-rats-with-irritable-bowel-syndrome
#20
Si-Yu Tao, Cong-Rui Xiao, Jing Wang, Shu-Jing Zhang, Yu-Shan Gao, Fang-Yuan Mu, Yi-Cheng Wang, Xing-Li Yan
This study aimed to investigate the effects of baldrinal of Valeriana jatamansi on the expression of corticotropin releasing factor (CRF) and tryptophan hydroxylase 1 (TPH1) mRNA and levels of 5-hydroxytryptamine (5-HT) in colon of rats with irritable bowel syndrome (IBS), and to explain its therapeutic mechanism on IBS through 5-HT pathway. Fifty-four male SD rats were randomly divided into 6 groups: blank group, model group, baldrinal high, medium and low dose groups, and pinaverium bromide group, n=9 in each group...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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