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https://www.readbyqxmd.com/read/29452281/incidence-and-risk-factors-of-post-operative-neurological-decline-after-complex-adult-spinal-deformity-surgery-results-of-the-scoli-risk-1-study
#1
Michael G Fehlings, So Kato, Lawrence G Lenke, Hiroaki Nakashima, Narihito Nagoshi, Christopher I Shaffrey, Kenneth M C Cheung, Leah Carreon, Mark B Dekutoski, Frank J Schwab, Oheneba Boachie-Adjei, Khaled M Kebaish, Christopher P Ames, Yong Qiu, Yukihiro Matsuyama, Benny T Dahl, Hossein Mehdian, Ferran Pellisé-Urquiza, Stephen J Lewis, Sigurd H Berven
BACKGROUND CONTEXT: Significant variability in neurologic outcomes following surgical correction for adult spinal deformity (ASD) has been reported. Risk factors for decline in neurologic motor outcomes are poorly understood. PURPOSE: The objective of the present investigation was to identify the risk factors for post-operative neurological motor decline in patients undergoing complex ASD surgery. STUDY DESIGN/SETTING: A prospective international multicenter cohort study...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29452273/3d-bioprinted-functional-and-contractile-cardiac-tissue-constructs
#2
Zhan Wang, Sang Jin Lee, Heng-Jie Cheng, James J Yoo, Anthony Atala
Bioengineering of a functional cardiac tissue composed of primary cardiomyocytes has great potential for myocardial regeneration and in vitro tissue modeling. However, its applications remain limited because the cardiac tissue is a highly organized structure with unique physiologic, biomechanical, and electrical properties. In this study, we undertook a proof-of-concept study to develop a contractile cardiac tissue with cellular organization, uniformity, and scalability by using three-dimensional (3D) bioprinting strategy...
February 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29451452/epidemiology-of-spinal-injury-in-childhood-and-adolescence-in-the-united-states-1997-2012
#3
Joseph Piatt, Nicholas Imperato
OBJECTIVE There has been no successful study of trends in population-based incidences of pediatric spinal injury in the United States. The goal of the current study was to develop robust data to correct this deficiency in contemporary trauma epidemiology. METHODS Discharges coded for spinal injury were extracted from the Kids' Inpatient Database for 1997, 2000, 2003, 2006, 2009, and 2012 for patients younger than 18 years. Childhood was defined as ages 0 through 14 years and adolescence as ages 15, 16, and 17 years...
February 16, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29445332/motor-unit-action-potential-clustering-theoretical-consideration-for-muscle-activation-during-a-motor-task
#4
Michael J Asmussen, Vinzenz von Tscharner, Benno M Nigg
During dynamic or sustained isometric contractions, bursts of muscle activity appear in the electromyography (EMG) signal. Theoretically, these bursts of activity likely occur because motor units are constrained to fire temporally close to one another and thus the impulses are "clustered" with short delays to elicit bursts of muscle activity. The purpose of this study was to investigate whether a sequence comprised of "clustered" motor unit action potentials (MUAP) can explain spectral and amplitude changes of the EMG during a simulated motor task...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29438131/improved-neurodevelopment-following-antiretroviral-therapy-in-hiv-infected-children
#5
Laurén A Gómez, Claudia S Crowell, Irene Njuguna, Lisa M Cranmer, Dalton Wamalwa, Daisy Chebet, Vincent Otieno, Elizabeth Maleche-Obimbo, Melissa Gladstone, Grace John-Stewart, Sarah Benki-Nugent
BACKGROUND: Late HIV diagnosis following severe co-morbidity remains common in resource limited settings. Neurodevelopmental recovery during antiretroviral therapy (ART) for late-diagnosed children is understudied. We determined 6-month neurodevelopmental trajectories in HIV-infected children initiating ART during hospitalization. METHODS: HIV-infected children initiated ART following HIV diagnosis during hospitalization in Kenya. The Malawi Developmental Assessment Tool (MDAT) was administered after clinical stabilization within 1-month and at 6-months post-ART initiation...
February 12, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29436982/examining-the-association-between-executive-functions-and-developmental-domains-of-low-income-children-in-the-united-states-and-turkey
#6
Mubeccel Gonen, Tulin Guler-Yildiz, Ayca Ulker-Erdem, Aileen Garcia, Helen Raikes, Ibrahim H Acar, Feyza Ozkan-Yildiz, Ipek Karlidag, Sukran Ucus, Dawn L Davis
This study examined the relations between executive functions and developmental domains of preschool children from low-income families through an intercultural perspective in the U.S. and Turkey. A total of 471 children and their primary caregivers participated in the Turkey part of the study, while 286 children and their parents engaged in U.S. SAMPLE: Regression analyses revealed that fine motor, problem solving, and executive functions of children between two contexts were significantly different from each other...
January 1, 2018: Psychological Reports
https://www.readbyqxmd.com/read/29433600/development-and-preliminary-testing-of-the-brief-developmental-assessment-an-early-recognition-tool-for-children-with-heart-disease
#7
Jo Wray, Katherine L Brown, Deborah Ridout, Monica Lakhanpaul, Liz Smith, Angie Scarisbrick, Sara O'Curry, Aparna Hoskote
Introduction Neurodevelopmental abnormalities are common in children with CHD and are the highest-priority concerns for parents and professionals following cardiac surgery in childhood. There is no additional routine monitoring of development for children with CHD in the United Kingdom; hence, neurodevelopmental concerns may be detected late, precluding early referral and intervention. METHODS: An early recognition tool - the "Brief Developmental Assessment" - was developed using quality improvement methodology involving several iterations and rounds of pilot testing...
February 13, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29433458/ecological-study-of-road-traffic-injuries-in-the-eastern-mediterranean-region-country-economic-level-road-user-category-and-gender-perspectives
#8
Mathilde Sengoelge, Lucie Laflamme, Ziad El-Khatib
BACKGROUND: The Eastern Mediterranean region has the second highest number of road traffic injury mortality rates after the African region based on 2013 data, with road traffic injuries accounting for 27% of the total injury mortality in the region. Globally the number of road traffic deaths has plateaued despite an increase in motorization, but it is uncertain whether this applies to the Region. This study investigated the regional trends in both road traffic injury mortality and morbidity and examined country-based differences considering on income level, categories of road users, and gender distribution...
February 13, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29433145/effect-of-cord-blood-magnesium-level-at-birth-on-non-neurologic-neonatal-outcomes
#9
James M Edwards, Laura E Edwards, Geeta K Swamy, Chad A Grotegut
OBJECTIVE: We examined the effects of magnesium sulfate on non-neurologic neonatal outcomes with respect to cord blood magnesium level. STUDY DESIGN: We conducted a secondary analysis of the Maternal-Fetal Medicine Units Beneficial Effects of Antenatal Magnesium (MFMU BEAM) trial comparing the upper and lower quintiles of cord blood magnesium level. Outcomes included cerebral palsy (CP), necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), and assessments of mental and motor disability...
February 12, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29433111/-acute-flaccid-myelitis
#10
Ryutaro Kira
Acute flaccid myelitis (AFM) is a newly defined, rare, but clinically distinct syndrome of acute flaccid paralysis with spinal motor neuron involvement of unknown etiology. Clusters of AFM coincided with a nationwide outbreak of enterovirus D68 (EV-D68) in the United States during autumn to winter of 2014 and in Japan during the autumn of 2015. Although EV-D68 was detected in only 20% of the AFM patients, mainly from respiratory specimens without apparent viral detection from blood and cerebrospinal fluid (CSF) samples, strong temporal associations were noted...
February 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29432721/vastus-lateralis-motor-unit-firing-rate-is-higher-in-females-with-patellofemoral-pain
#11
Alessio Gallina, Michael A Hunt, Paul Hodges, S Jayne Garland
OBJECTIVE: To compare neural drive, determined from motor unit firing rate, to the vastus medialis and lateralis in females with and without patellofemoral pain. DESIGN: Cross-sectional study. SETTING: University research laboratory. PARTICIPANTS: Females (N=56) 19-35 years old, 36 with patellofemoral pain and 20 controls. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE(S): Participants sustained an isometric knee extension contraction at 10% of their maximal voluntary effort for 70s...
February 9, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29429614/inversely-active-striatal-projection-neurons-and-interneurons-selectively-delimit-useful-behavioral-sequences
#12
Nuné Martiros, Alexandra A Burgess, Ann M Graybiel
Understanding neural representations of behavioral routines is critical for understanding complex behavior in health and disease. We demonstrate here that accentuated activity of striatal projection neurons (SPNs) at the beginning and end of such behavioral repertoires is a supraordinate representation specifically marking previously rewarded behavioral sequences independent of the individual movements making up the behavior. We recorded spike activity in the striatum and primary motor cortex as individual rats learned specific rewarded lever-press sequences, each one unique to a given rat...
February 1, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29428252/delirium-during-the-first-evaluation-of-children-aged-five-to-14%C3%A2-years-admitted-to-a-paediatric-critical-care-unit
#13
Eliana María Cano Londoño, Isabel Cristina Mejía Gil, Katerine Uribe Hernández, Carmenza Ricardo Ramírez, Matilde Ligia Álvarez Gómez, Ricardo Antonio Consuegra Peña, Camilo Andrés Agudelo Vélez, Susana Zuluaga Penagos, Mussatye Elorza Parra, José G Franco Vásquez
OBJECTIVES: To describe the prevalence and characteristics of delirium during the initial evaluation of critically ill patients aged 5-14 years. METHOD/DESIGN: This is a cross-sectional descriptive study in a critical care unit. For six months, all patients were evaluated within the first 24-72 hours or when sedation permitted the use of the paediatric confusion assessment method for the intensive care unit (PCAM-ICU) and the Delirium Rating Scale-Revised-98 items #7 and #8 to determine motor type...
February 7, 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/29427557/motor-unit-number-index-munix-guidelines-for-recording-signals-and-their-analysis
#14
Sanjeev D Nandedkar, Paul E Barkhaus, Erik V Stålberg, Christoph Neuwirth, Markus Weber
INTRODUCTION: This study proposes guidelines for motor unit number index (MUNIX) recording and analysis. METHODS: MUNIX was measured in control subjects and patients with amyotrophic lateral sclerosis. Changes in MUNIX due to E1 electrode position, number of surface EMG interference pattern (SIP) epochs, SIP epoch duration, force of contraction, and outlier data points were investigated. RESULTS: MUNIX depends on optimized CMAP amplitude. Individual muscles showed variations when the number of epochs was low, or when the SIP duration was short...
February 10, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29426320/supporting-play-exploration-and-early-developmental-intervention-versus-usual-care-to-enhance-development-outcomes-during-the-transition-from-the-neonatal-intensive-care-unit-to-home-a-pilot-randomized-controlled-trial
#15
Stacey C Dusing, Tanya Tripathi, Emily C Marcinowski, Leroy R Thacker, Lisa F Brown, Karen D Hendricks-Muñoz
BACKGROUND: While therapy services may start in the Neonatal Intensive Care Unit (NICU) there is often a gap in therapy after discharge. Supporting Play Exploration and Early Development Intervention (SPEEDI) supports parents, helping them build capacity to provide developmentally supportive opportunities starting in the NICU and continuing at home. The purpose of this single blinded randomized pilot clinical trial was to evaluate the initial efficacy of SPEEDI to improve early reaching and exploratory problem solving behaviors...
February 9, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29424609/effects-of-mental-fatigue-on-physical-endurance-performance-and-muscle-activation-are-attenuated-by-monetary-incentives
#16
Denver M Y Brown, Steven R Bray
Physical performance is impaired following cognitive control exertion. Incentives can ameliorate adverse carryover effects of cognitive control exertion but have not been investigated for physical endurance. This study examined the effect of monetary incentives on physical performance and muscle activation following exposure to a mentally fatiguing, cognitive control task. Participants (N = 82) performed two isometric endurance handgrip trials separated by a 12-min cognitive control manipulation using a 2 (high cognitive control [HCC]/low cognitive control [LCC]) × 2 (incentive/no incentive) design...
February 9, 2018: Journal of Sport & Exercise Psychology
https://www.readbyqxmd.com/read/29424359/motor-unit-number-index-munix-derivation-from-the-relationship-between-the-area-and-power-of-surface-electromyogram-a-computer-simulation-and-clinical-study
#17
Francesc Miralles
Objetive. MUNIX is a technique based on surface electromyogram (sEMG) that is gaining acceptance as a method to monitoring motor neuron loss because is reliable and produces less discomfort than other electrodiagnostic techniques aimed to the same purpose. MUNIX assumes that the relationship between the area of sEMG obtained at increasing levels of muscle activation and the values of a variable called "Ideal case motor unit count" (ICMUC), defined as the product of the ratio between area and power of the M-wave by that of the sEMG, is described by a decreasing power function...
February 9, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29420800/yesterday-and-today-the-impact-of-research-conducted-at-camp-detrick-on-botulinum-toxin
#18
Frank J Lebeda, Michael Adler, Zygmunt F Dembek
Introduction: This review summarizes the research conducted on botulinum toxin (BoTx) from 1943 to 1956 by a small group of Camp Detrick investigators and their staff. A systematic, cross-disciplinary approach was used to develop effective vaccines against this biological warfare threat agent. In response to the potential need for medical countermeasures against BoTx during World War II, the refinement of isolation and purification techniques for BoTx successfully led to the large-scale production of botulinum toxoid vaccines...
February 6, 2018: Military Medicine
https://www.readbyqxmd.com/read/29420610/estimation-of-actomyosin-active-force-maintained-by-tropomyosin-and-troponin-complex-under-vertical-forces-in-the-in-vitro-motility-assay-system
#19
Shuya Ishii, Masataka Kawai, Shin'ichi Ishiwata, Madoka Suzuki
The interaction between actin filaments and myosin molecular motors is a power source of a variety of cellular functions including cell division, cell motility, and muscular contraction. In vitro motility assay examines actin filaments interacting with myosin molecules that are adhered to a substrate (e.g., glass surface). This assay has been the standard method of studying the molecular mechanisms of contraction under an optical microscope. While the force generation has been measured through an optically trapped bead to which an actin filament is attached, a force vector vertical to the glass surface has been largely ignored with the in vitro motility assay...
2018: PloS One
https://www.readbyqxmd.com/read/29420155/surface-emg-amplitude-does-not-identify-differences-in-neural-drive-to-synergistic-muscles
#20
Eduardo Martinez Valdes, Francesco Negro, Deborah Falla, Alessandro Marco De Nunzio, Dario Farina
Surface electromyographic (EMG) signal amplitude is typically used to compare the neural drive to muscles. We experimentally investigated this association by studying the motor unit (MU) behavior and action potentials in the vastus medialis (VM) and vastus lateralis (VL) muscles. Eighteen participants performed isometric knee extensions at four target torques [10, 30, 50 and 70% of the maximum torque (MVC)] while high-density EMG signals were recorded from the VM and VL. The absolute EMG amplitude was greater for VM than VL (p<0...
February 8, 2018: Journal of Applied Physiology
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